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203. Erweiterte Resektion des piriformen Cortex ist entscheidend für die post-operative Anfallsfreiheit nach einer selektiven Amygdalohippocampektomie

Author

Borger, Valeri, Schneider, Matthias, Potthoff, Anna-Laura, Keil, Vera C., Hamed, Motaz, Aydin, Gülsah, Ilic, Inja, Solymosi, László, Elger, Christian E., Güresir, Erdem, Fimmers, Rolf, Schuss, Patrick, Surges, Rainer, and Vatter, Hartmut

Subjects
ddc: 610, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Transsylvian selective amygdalo-hippocampectomy (tsSAHE) represents a valid surgical procedure for drug-resistant mesial temporal lobe epilepsy (mTLE). However, although postoperative seizure freedom can be achieved in about 70% of tsSAHE, there is a considerable amount of patients with[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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204. Epilepsy Subtype-Specific Copy Number Burden Observed in a Genome-Wide Study of 17 458 Subjects

Author

Niestroj, Lisa-Marie, Perez-Palma, Eduardo, Howrigan, Daniel P., Zhou, Yadi, Cheng, Feixiong, Saarentaus, Elmo, Nürnberg, Peter, Stevelink, Remi, Daly, Mark J., Palotie, Aarno, Lal, Dennis, Feng, Yen-Chen Anne, Abbott, Liam E., Tashman, Katherine, Cerrato, Felecia, Churchhouse, Claire, Gupta, Namrata, Neale, Benjamin M., Berkovic, Samuel F., Lerche, Holger, Goldstein, David B., Lowenstein, Daniel H., Cavalleri, Gianpiero L., Cossette, Patrick, Cotsapas, Chris, Dixon-Salazar, Tracy, Guerrini, Renzo, Hakonarson, Hakon, Heinzen, Erin L., Helbig, Ingo, Kwan, Patrick, Marson, Anthony G., Petrovski, Slavé, Kamalakaran, Sitharthan, Sisodiya, Sanjay M., Stewart, Randy, Depondt, Chantal, Dlugos, Dennis J., Scheffer, Ingrid E., Striano, Pasquale, Freyer, Catharine, Krause, Roland, May, Patrick, McKenna, Kevin, Regan, Brigid M., Bellows, Susannah T., Leu, Costin, Bennett, Caitlin A., Johns, Esther C., Macdonald, Alexandra, Shilling, Hannah, Burgess, Rosemary, Weckhuysen, Dorien, Bahlo, Melanie, O’Brien, Terence J., Todaro, Marian, Weckhuysen, Sarah, Stamberger, Hannah, De Jonghe, Peter, Andrade, Danielle M., Sadoway, Tara R., Mo, Kelly, Krestel, Heinz, Gallati, Sabina, Papacostas, Savvas S., Kousiappa, Ioanna, Tanteles, George A., Šterbová, Katalin, Vlcková, Markéta, Sedlácková, Lucie, Laššuthová, Petra, Klein, Karl Martin, Rosenow, Felix, Reif, Philipp S., Knake, Susanne, Kunz, Wolfram S., Zsurka, Gábor, Elger, Christian E., Bauer, Jürgen, Rademacher, Michael, Pendziwiat, Manuela, Muhle, Hiltrud, Rademacher, Annika, van Baalen, Andreas, von Spiczak, Sarah, Stephani, Ulrich, Afawi, Zaid, Korczyn, Amos D., Kanaan, Moien, Canavati, Christina, Kurlemann, Gerhard, Müller-Schlüter, Karen, Kluger, Gerhard, Häusler, Martin, Blatt, Ilan, Lemke, Johannes R., Krey, Ilona, Weber, Yvonne G., Wolking, Stefan, Becker, Felicitas, Hengsbach, Christian, Rau, Sarah, Maisch, Ana F., Steinhoff, Bernhard J., Schulze-Bonhage, Andreas, Schubert-Bast, Susanne, Schreiber, Herbert, Borggräfe, Ingo, Schankin, Christoph J., Mayer, Thomas, Korinthenberg, Rudolf, Brockmann, Knut, Dennig, Dieter, Madeleyn, Rene, Kälviäinen, Reetta, Auvinen, Pia, Saarela, Anni, Linnankivi, Tarja, Lehesjoki, Anna-Elina, Rees, Mark I., Chung, Seo-Kyung, Pickrell, William O., Powell, Robert, Schneider, Natascha, Balestrini, Simona, Zagaglia, Sara, Braatz, Vera, Johnson, Michael R., Auce, Pauls, Sills, Graeme J., Baum, Larry W., Sham, Pak C., Cherny, Stacey S., Lui, Colin H. T., Barišic, Nina, Delanty, Norman, Doherty, Colin P., Shukralla, Arif, McCormack, Mark, El-Naggar, Hany, Canafoglia, Laura, Franceschetti, Silvana, Castellotti, Barbara, Granata, Tiziana, Zara, Federico, Iacomino, Michele, Madia, Francesca, Vari, Maria Stella, Mancardi, Maria Margherita, Salpietro, Vincenzo, Bisulli, Francesca, Tinuper, Paolo, Licchetta, Laura, Pippucci, Tommaso, Stipa, Carlotta, Muccioli, Lorenzo, Minardi, Raffaella, Gambardella, Antonio, Labate, Angelo, Annesi, Grazia, Manna, Lorella, Gagliardi, Monica, Parrini, Elena, Mei, Davide, Vetro, Annalisa, Bianchini, Claudia, Montomoli, Martino, Doccini, Viola, Marini, Carla, Suzuki, Toshimitsu, Inoue, Yushi, Yamakawa, Kazuhiro, Tumiene, Birute, Mameniskiene, Ruta, Utkus, Algirdas, Praninskiene, Ruta, Grikiniene, Jurgita, Samaitiene, Ruta, Sadleir, Lynette G., King, Chontelle, Mountier, Emily, Caglayan, S. Hande, Arslan, Mutluay, Yapici, Zuhal, Yis, Uluc, Topaloglu, Pinar, Kara, Bulent, Turkdogan, Dilsad, Gundogdu-Eken, Asli, Bebek, Nerses, Ugur-Iseri, Sibel, Baykan, Betül, Salman, Baris, Haryanyan, Garen, Yücesan, Emrah, Kesim, Yesim, Özkara, Çigdem, Sheidley, Beth R., Shain, Catherine, Poduri, Annapurna, Buono, Russell J, Ferraro, Thomas N, Sperling, Michael R., Lo, Warren, Privitera, Michael, French, Jacqueline A., Schachter, Steven, Kuzniecky, Ruben I., Devinsky, Orrin, Hegde, Manu, Khankhanian, Pouya, Helbig, Katherine L., Ellis, Colin A., Spalletta, Gianfranco, Piras, Fabrizio, Piras, Federica, Gili, Tommaso, Ciullo, Valentina, YÜCESAN, EMRAH, Niestroj L.-M., Perez-Palma E., Howrigan D.P., Zhou Y., Cheng F., Saarentaus E., Nurnberg P., Stevelink R., Daly M.J., Palotie A., Lal D, Epi 25 Collaborative, Bisulli F., Tinuper P., Licchetta L., and Epi25 Collaborative

Subjects
Developmental and epileptic encephalopathy, Male, 0301 basic medicine, DNA Copy Number Variations, Disease, Bioinformatics, Genome, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, copy number variation, developmental and epileptic encephalopathy, epilepsy, focal epilepsy, genetic generalized epilepsy, medicine, Humans, Genetic Predisposition to Disease, Copy-number variation, Generalized epilepsy, DNA Copy Number Variation, Copy number variation, business.industry, Breakpoint, Focal epilepsy, Original Articles, medicine.disease, 3. Good health, Genetic generalized epilepsy, 030104 developmental biology, Female, Human medicine, Neurology (clinical), Personalized medicine, business, 030217 neurology & neurosurgery, Genome-Wide Association Study, Human
Abstract

Cytogenic testing is routinely applied in most neurological centres for severe paediatric epilepsies. However, which characteristics of copy number variants (CNVs) confer most epilepsy risk and which epilepsy subtypes carry the most CNV burden, have not been explored on a genome-wide scale. Here, we present the largest CNV investigation in epilepsy to date with 10 712 European epilepsy cases and 6746 ancestry-matched controls. Patients with genetic generalized epilepsy, lesional focal epilepsy, non-acquired focal epilepsy, and developmental and epileptic encephalopathy were included. All samples were processed with the same technology and analysis pipeline. All investigated epilepsy types, including lesional focal epilepsy patients, showed an increase in CNV burden in at least one tested category compared to controls. However, we observed striking differences in CNV burden across epilepsy types and investigated CNV categories. Genetic generalized epilepsy patients have the highest CNV burden in all categories tested, followed by developmental and epileptic encephalopathy patients. Both epilepsy types also show association for deletions covering genes intolerant for truncating variants. Genome-wide CNV breakpoint association showed not only significant loci for genetic generalized and developmental and epileptic encephalopathy patients but also for lesional focal epilepsy patients. With a 34-fold risk for developing genetic generalized epilepsy, we show for the first time that the established epilepsy-associated 15q13.3 deletion represents the strongest risk CNV for genetic generalized epilepsy across the whole genome. Using the human interactome, we examined the largest connected component of the genes overlapped by CNVs in the four epilepsy types. We observed that genetic generalized epilepsy and non-acquired focal epilepsy formed disease modules. In summary, we show that in all common epilepsy types, 1.5–3% of patients carry epilepsy-associated CNVs. The characteristics of risk CNVs vary tremendously across and within epilepsy types. Thus, we advocate genome-wide genomic testing to identify all disease-associated types of CNVs.

Published
2020

205. ¹⁸F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis

Author

Deuschl, Cornelius, Rüber, Theodor, Ernst, Leon, Fendler, Wolfgang P., Kirchner, Julian, Mönninghoff, Christoph, Herrmann, Ken, Quesada, Carlos M., Forsting, Michael, Elger, Christian E., and Umutlu, Lale

Subjects
Medizin
Abstract

Introduction Limbic encephalitis (LE) is an immune-related, sometimes paraneoplastic process of the central nervous system. Initial diagnosis and treatment are based on the clinical presentation as well as antibody profiles and MRI. This study investigated the diagnostic value of integrated ¹⁸F-FDG-PET/MRI in the diagnostic work-up of patients with LE for a cerebral and whole-body imaging concept. Material and methods Twenty patients with suspected LE were enrolled in this prospective study. All patients underwent a dedicated PET/MRI protocol of the brain as well as the whole-body. Two neuroradiologists, one body radiologist and one nuclear medicine physician performed blinded consensus readings of each corresponding MRI and PET/MRI dataset of the brain and whole-body. Diagnostic confidence was evaluated on a Likert scale. Results Based on integrated PET/MRI 19 / 20 patients were found to show morphologic and / or metabolic changes indicative of LE, whereas sole MRI enabled correct identification in 16 / 20 patients. Three patients with negative MRI showed metabolic changes of the limbic system or extra-limbic regions, shifting the diagnosis from (negative) MRI to positive for LE in PET/MRI. Whole-body staging revealed suspected lesions in 2/20 patients, identified by MRI and PET, one confirmed as malignant and one false positive. Diagnostic confidence for cerebral and whole-body imaging reached higher scores for PET/MRI (cerebral: 2.7 and whole body: 4.8) compared to MRI alone (cerebral: 2.4 and whole body: 4.5). Conclusion LE diagnosis remains challenging for imaging as it shows only subtle imaging findings in most patients. Nevertheless, based on the simultaneous and combined analysis of morphologic and metabolic data, integrated PET/MRI may enable a dual platform for improved diagnostic confidence and overall detection of LE as well as whole-body imaging for exclusion of paraneoplastic LE. OA Förderung 2020

Published
2020

210. How generalised are secondarily 'generalised' tonic-clonic seizures?

Author

Schindler, Kaspar, Leung, Howan, Lehnertz, Klaus, and Elger, Christian E.

Subjects
Cerebral cortex -- Physiological aspects, Electroencephalography -- Evaluation, Epilepsy -- Diagnosis, Epilepsy -- Research, Electrophysiology -- Research, Health, Psychology and mental health
Published
2007

211. Inheritance of mitochondrial DNA recombinants in double-heteroplasmic families: Potential implications for phylogenetic analysis

Author

Zsurka, Gabor, Hampel, Kevin G., Kudina, Tatiana, Kornblum, Cornelia, Kraytsberg, Yevgenia, Elger, Christian E., Khrapko, Konstantin, and Kunz, Wolfram S.

Subjects
Phylogeny -- Research, Mitochondrial DNA -- Atomic properties, Mitochondrial DNA -- Research, Biological sciences
Abstract

Two families, each harboring two inherited heteroplasmic mtDNA mutations are investigated to determine whether recombinant mtDNA molecules can be transmitted through the germ line. Findings suggest that recombinant mtDNA molecules can be transmitted through the germ line and this feature explains the presence of certain allelic combinations in maternal lineages that cannot be inferred from a plain sequential order of mutational events.

Published
2007

221. Adult-onset temporal lobe epilepsy suspicious for autoimmune pathogenesis: Autoantibody prevalence and clinical correlates

Author

Kuehn, Julia C., primary, Meschede, Carolin, additional, Helmstaedter, Christoph, additional, Surges, Rainer, additional, von Wrede, Randi, additional, Hattingen, Elke, additional, Vatter, Hartmut, additional, Elger, Christian E., additional, Schoch, Susanne, additional, Becker, Albert J., additional, and Pitsch, Julika, additional

Published
2020
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223. Structural network topology in limbic encephalitis is associated with amygdala enlargement, memory performance and serostatus

Author

Bauer, Tobias, primary, David, Bastian, additional, Ernst, Leon, additional, Becker, Albert J., additional, Witt, Juri‐Alexander, additional, Helmstaedter, Christoph, additional, Wagner, Jan, additional, Weber, Bernd, additional, Elger, Christian E., additional, Surges, Rainer, additional, and Rüber, Theodor, additional

Published
2020
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224. Blood and cerebrospinal fluid immune cell profiles in patients with temporal lobe epilepsy of different etiologies

Author

Langenbruch, Lisa, primary, Bleß, Laurens, additional, Schulte‐Mecklenbeck, Andreas, additional, Sundermann, Benedikt, additional, Brix, Tobias, additional, Elger, Christian E., additional, Melzer, Nico, additional, Wiendl, Heinz, additional, Meuth, Sven G., additional, Gross, Catharina C., additional, and Kovac, Stjepana, additional

Published
2020
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227. Neural bases of cognitive ERPs: more than phase reset

Author

Fell, Juergen, Dietl,Thomas, Grunwald, Thomas, Kurthen, Martin, Klaver, Peter, Trautner, Peter, Schaller, Carlo, Elger, Christian E., and Fernandez, Guillen

Subjects
Cognition -- Research, Neurology -- Research, Health, Psychology and mental health
Published
2004

236. Ictal EEG recording is not mandatory in all candidates for paediatric epilepsy surgery with clear MRI lesions and corresponding seizure semiology

Author

Makridis, Konstantin L., Prager, Christine, Atalay, Deniz A., Triller, Sebastian, Rosenstock, Tizian, Thomale, Ulrich‐Wilhelm, Tietze, Anna, Elger, Christian E., and Kaindl, Angela M.

Abstract

Objective. Epilepsy surgery can potentially cure drug‐resistant epilepsy, but careful presurgical evaluation is vital to select patients who will profit from such an intervention. Many epilepsy surgery programs offer extensive presurgical evaluation including several days of video‐EEG monitoring. Non‐lesional epilepsy cases are rare among epilepsy surgery patients. We set up a lesionorientated paediatric epilepsy surgery program for patients with clearly localized lesions with limited presurgical diagnostics, in particular, with a maximum of 48 hours of non‐invasive EEG monitoring that did not necessarily include ictal EEGs. Methods. We retrospectively evaluated the outcome of patients who were operated on within our epilepsy surgery program with respect to seizure freedom. Results. Fifty‐two children and adolescents with MRI lesions at a mean age of 8.27 ± 4.83 years (range: 0.17‐18.87) underwent a resective procedure. The most frequent surgery was a hemispherotomy. Overall seizure freedom was 81.8% after 12 months and 85.6% after a median observation period of 20.45 months. Seizure frequency was reduced >50% in all other patients. Preoperative recording of an ictal EEG on the side of surgery had no effect on postoperative seizure outcome (p= 0.697), nor did recording of epileptiform discharges on the ipsilateral (p= 0.538) and contralateral side (p= 0.147). Significance. Our findings highlight the high success rate using a lesionorientated epilepsy surgical approach with reduced presurgical video‐EEG monitoring in the paediatric epilepsy population. Our data show that it is possible to reduce the complex pre‐surgical work‐up for epilepsy in children and adolescents by asking the basic question: “Is there any reason why the lesion should not be resected”.

Published
2022
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237. Discerning nonstationarity from nonlinearity in seizure-free and preseizure EEG recordings from epilepsy patients

Author

Rieke, Christoph, Mormann, Florian, Andrzejak, Ralph G., Kreuz, Thomas, David, Peter, Elger, Christian E., and Lehnertz, Klaus

Subjects
Electroencephalography -- Research, Biological sciences, Business, Computers, Health care industry
Abstract

A number of recent studies indicate that nonlinear electroencephalogram (EEG) analyses allow to define a state predictive of an impending epileptic seizure. In this paper, we combine a method for detecting nonlinear determinism with a novel test for stationarity to characterize EEG recordings from both the seizure-free interval and the preseizure phase. We discuss differences between these periods, particularly an increased occurrence of stationary, nonlinear segments prior to seizures. These differences seem most prominent for recording sites within the seizure-generating area and for EEG segments less than one minute's length. Index Terms--EEG, epilepsy, nonlinear time series analysis, nonlinearity, nonstationarity, seizure prediction.

Published
2003

238. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32

Author

Steffens, Michael, Leu, Costin, Ruppert, Ann-Kathrin, Zara, Federico, Striano, Pasquale, Robbiano, Angela, Capovilla, Giuseppe, Tinuper, Paolo, Gambardella, Antonio, Bianchi, Amedeo, La Neve, Angela, Crichiutti, Giovanni, de Kovel, Carolien G.F., Kasteleijn-Nolst Trenité, Dorothée, de Haan, Gerrit-Jan, Lindhout, Dick, Gaus, Verena, Schmitz, Bettina, Janz, Dieter, Weber, Yvonne G., Becker, Felicitas, Lerche, Holger, Steinhoff, Bernhard J., Kleefu-Lie, Ailing A., Kunz, Wolfram S., Surges, Rainer, Elger, Christian E., Muhle, Hiltrud, von Spiczak, Sarah, Ostertag, Philipp, Helbig, Ingo, Stephani, Ulrich, Møller, Rikke S., Hjalgrim, Helle, Dibbens, Leanne M., Bellows, Susannah, Oliver, Karen, Mullen, Saul, Scheffer, Ingrid E., Berkovic, Samuel F., Everett, Kate V., Gardiner, Mark R., Marini, Carla, Guerrini, Renzo, Lehesjoki, Anna-Elina, Siren, Auli, Guipponi, Michel, Malafosse, Alain, Thomas, Pierre, Nabbout, Rima, Baulac, Stephanie, Leguern, Eric, Guerrero, Rosa, Serratosa, Jose M., Reif, Philipp S., Rosenow, Felix, Mörzinger, Martina, Feucht, Martha, Zimprich, Fritz, Kapser, Claudia, Schankin, Christoph J., Suls, Arvid, Smets, Katrin, De Jonghe, Peter, Jordanova, Albena, Caglayan, Hande, Yapici, Zuhal, Yalcin, Destina A., Baykan, Betul, Bebek, Nerses, Ozbek, Ugur, Gieger, Christian, Wichmann, Heinz-Erich, Balschun, Tobias, Ellinghaus, David, Franke, Andre, Meesters, Christian, Becker, Tim, Wienker, Thomas F., Hempelmann, Anne, Schulz, Herbert, Rüschendorf, Franz, Leber, Markus, Pauck, Steffen M., Trucks, Holger, Toliat, Mohammad R., Nürnberg, Peter, Avanzini, Giuliano, Koeleman, Bobby P.C., and Sander, Thomas

Published
2012
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239. Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality.

Author

Fauser, Susanne, Elger, Christian E., Woermann, Friedrich, and Bien, Christian G.

Subjects
*ENCEPHALITIS, *BRAIN damage, *AUTOIMMUNITY, *MULTIPLE pregnancy, *PREMATURE labor, *PARTIAL epilepsy
Abstract

Objective: Rasmussen encephalitis (RE) is a progressive and destructive inflammatory disease of one hemisphere. Its cause is unknown. We investigated comorbidity and laterality factors that might predispose to RE. Methods: We retrospectively compared the histories of 160 RE patients to those with genetic generalized epilepsy (n = 154) and those with focal cortical dysplasia Type II (FCD II; n = 148). Results: The median/mean age at symptom onset in RE was 7/10 years (range = 1–53 years), and 58.1% of the patients were female. The female sex predominated in RE patients, with age > 7 years at disease manifestation. The left hemisphere was affected in 65.6%. Perinatal complications (preterm birth, twin pregnancies, early acquired brain lesions) were more frequent in RE than in control patients. Ipsilateral facial autoimmune conditions (scleroderma en coup de sabre, uveitis, or chorioretinitis) were only observed in RE patients (6.9%). Onset of RE was more frequently associated with fever than that of FCD II. In 33.1% of RE patients, ≥1 potential risk factor was found. Interestingly, 11.9% of patients had one‐sided early brain lesions or facial autoimmune lesions ipsilateral to subsequent RE; none had such a lesion contralaterally. Significance: Perinatal complications and facial autoimmune conditions may act as predisposing factors for RE. Fever might trigger RE manifestation. Further genetic or infectious contributors may be identified in the future. Single or combined hits may be required to elicit or facilitate the start of the disease. Ipsilateral early comorbid lesions or facial autoimmune processes might in part explain the enigmatic unilaterality of RE. [ABSTRACT FROM AUTHOR]

Published
2022
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241. Treating Epilepsy

Author

Reuber, Markus, primary, Schachter, Steven C, additional, Elger, Christian E, additional, and Altrup, Ulrich, additional

Published
2009
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243. Epilepsy Research

Author

Reuber, Markus, primary, Schachter, Steven C, additional, Elger, Christian E, additional, and Altrup, Ulrich, additional

Published
2009
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244. Renovascular Hypertension

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
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245. Rhinitis, Allergic

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
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246. Roseola Infantum

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
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247. RTH

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
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248. Reye’s Syndrome

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
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249. Rod Monochromatism

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
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250. Reiter’s Triad

Author

Bien, Christian G., primary, Elger, Christian E., additional, Afzal, Ali R., additional, Natah, Sirajedin, additional, Häyrinen-Immonen, Ritva, additional, Konttinen, Yrjö, additional, Zubenko, George S., additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Marinella, Mark A., additional, Kohlschütter, Alfried, additional, Nguyen, Tam, additional, Shirali, Anushree C., additional, Goldstein, Daniel R., additional, Samaniego, Millie, additional, Kaplan, Bruce, additional, Hansson, Ann-Sofie, additional, Raggio, Julie, additional, Welch, William J., additional, Teh, Bin Tean, additional, Yang, Ximing J., additional, Teh, Bin Sing, additional, Kahnoski, Richard J., additional, Vogelzang, Nicholas J., additional, Iyengar, Sudha K., additional, Freedman, Barry I., additional, Sperling, Oded, additional, Dhalla, Naranjan S., additional, Saini, Harjot K., additional, Sancak, Seda, additional, Paschke, Ralf, additional, Sugrue, Richard J., additional, Kuba, Keiji, additional, Imai, Yumiko, additional, Penninger, Josef, additional, Kassubek, Jan, additional, Unrath, Alexander, additional, Wallace, Margaret R., additional, Pauly, Daniel F., additional, Chetta, Alfredo, additional, Olivieri, Dario, additional, Ruether, Klaus, additional, Berger, Wolfgang, additional, Lohmann, Dietmar, additional, Lang, Gabriele E., additional, Huppke, Peter, additional, Häberle, Johannes, additional, Nuoffer, Jean-Marc, additional, Steer, Andrew C., additional, Carapetis, Jonathan R., additional, McInnes, Iain B., additional, Rangel-Moreno, Javier, additional, Randall, Troy D., additional, Heppt, Werner J., additional, Cryer, Annette, additional, Bams-Mengerink, Annemieke M., additional, Brites, Pedro, additional, Poll-The, Bwee Tien, additional, Wanders, Ronald J. A., additional, Tenenhouse, Harriet S., additional, Ma, Siobhan D., additional, Ma, Patrick T. S., additional, Leung, Alexander K. C., additional, Zehelein, Joerg, additional, Khalil, Markus, additional, Koenen, Michael, additional, Zouboulis, Christos C., additional, Kaplan, Kevin, additional, Meislin, Robert J., additional, Davies, H. Dele, additional, Metze, Dieter, additional, Jansen, Peter L. M., additional, Sauve, Reginald S., additional, Robson, William Lane M., additional, Gervasini, Cristina, additional, Bentivegna, Angela, additional, and Larizza, Lidia, additional

Published
2009
Full Text
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