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201. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Author: Wyss, Annah B., Sofer, Tamar, Lee, Mi Kyeong, Terzikhan, Natalie, Nguyen, Jennifer N., Lahousse, Lies, Latourelle, Jeanne C., Smith, Albert Vernon, Bartz, Traci M., Feitosa, Mary F., Gao, Wei, Ahluwalia, Tarunveer S., Tang, Wenbo, Oldmeadow, Christopher, Duan, Qing, de Jong, Kim, Wojczynski, Mary K., Wang, Xin-Qun, Noordam, Raymond, Hartwig, Fernando Pires, Jackson, Victoria E., Wang, Tianyuan, Obeidat, Ma'en, Hobbs, Brian D., Huan, Tianxiao, Gui, Hongsheng, Parker, Margaret M., Hu, Donglei, Mogil, Lauren S., Kichaev, Gleb, Jin, Jianping, Graff, Mariaelisa, Harris, Tamara B., Kalhan, Ravi, Heckbert, Susan R., Paternoster, Lavinia, Burkart, Kristin M., Liu, Yongmei, Holliday, Elizabeth G., Wilson, James G., Vonk, Judith M., Sanders, Jason L., Barr, R. Graham, de Mutsert, Renee, Baptista Menezes, Ana Maria, Adams, Hieab H. H., van den Berge, Maarten, Joehanes, Roby, Levin, Albert M., Liberto, Jennifer, Launer, Lenore J., Morrison, Alanna C., Sitlani, Colleen M., Celedon, Juan C., Kritchevsky, Stephen B., Scott, Rodney J., Christensen, Kaare, Rotter, Jerome I., Bonten, Tobias N., Wehrmeister, Fernando Cesar, Bosse, Yohan, Xiao, Shujie, Oh, Sam, Franceschini, Nora, Brody, Jennifer A., Kaplan, Robert C., Lohman, Kurt, McEvoy, Mark, Province, Michael A., Rosendaal, Frits R., Taylor, Kent D., Nickle, David C., Williams, L. Keoki, Burchard, Esteban G., Wheeler, Heather E., Sin, Don D., Gudnason, Vilmundur, North, Kari E., Fornage, Myriam, Psaty, Bruce M., Myers, Richard H., O'Connor, George, Hansen, Torben, Laurie, Cathy C., Cassano, Patricia A., Sung, Joohon, Kim, Woo Jin, Attia, John R., Lange, Leslie, Boezen, H. Marike, Thyagarajan, Bharat, Rich, Stephen S., Mook-Kanamori, Dennis O., Horta, Bernardo Lessa, Uitterlinden, Andre G., Im, Hae Kyung, Cho, Michael H., Brusselle, Guy G., Gharib, Sina A., Dupuis, Josee, Manichaikul, Ani, London, Stephanie J., Wyss, Annah B., Sofer, Tamar, Lee, Mi Kyeong, Terzikhan, Natalie, Nguyen, Jennifer N., Lahousse, Lies, Latourelle, Jeanne C., Smith, Albert Vernon, Bartz, Traci M., Feitosa, Mary F., Gao, Wei, Ahluwalia, Tarunveer S., Tang, Wenbo, Oldmeadow, Christopher, Duan, Qing, de Jong, Kim, Wojczynski, Mary K., Wang, Xin-Qun, Noordam, Raymond, Hartwig, Fernando Pires, Jackson, Victoria E., Wang, Tianyuan, Obeidat, Ma'en, Hobbs, Brian D., Huan, Tianxiao, Gui, Hongsheng, Parker, Margaret M., Hu, Donglei, Mogil, Lauren S., Kichaev, Gleb, Jin, Jianping, Graff, Mariaelisa, Harris, Tamara B., Kalhan, Ravi, Heckbert, Susan R., Paternoster, Lavinia, Burkart, Kristin M., Liu, Yongmei, Holliday, Elizabeth G., Wilson, James G., Vonk, Judith M., Sanders, Jason L., Barr, R. Graham, de Mutsert, Renee, Baptista Menezes, Ana Maria, Adams, Hieab H. H., van den Berge, Maarten, Joehanes, Roby, Levin, Albert M., Liberto, Jennifer, Launer, Lenore J., Morrison, Alanna C., Sitlani, Colleen M., Celedon, Juan C., Kritchevsky, Stephen B., Scott, Rodney J., Christensen, Kaare, Rotter, Jerome I., Bonten, Tobias N., Wehrmeister, Fernando Cesar, Bosse, Yohan, Xiao, Shujie, Oh, Sam, Franceschini, Nora, Brody, Jennifer A., Kaplan, Robert C., Lohman, Kurt, McEvoy, Mark, Province, Michael A., Rosendaal, Frits R., Taylor, Kent D., Nickle, David C., Williams, L. Keoki, Burchard, Esteban G., Wheeler, Heather E., Sin, Don D., Gudnason, Vilmundur, North, Kari E., Fornage, Myriam, Psaty, Bruce M., Myers, Richard H., O'Connor, George, Hansen, Torben, Laurie, Cathy C., Cassano, Patricia A., Sung, Joohon, Kim, Woo Jin, Attia, John R., Lange, Leslie, Boezen, H. Marike, Thyagarajan, Bharat, Rich, Stephen S., Mook-Kanamori, Dennis O., Horta, Bernardo Lessa, Uitterlinden, Andre G., Im, Hae Kyung, Cho, Michael H., Brusselle, Guy G., Gharib, Sina A., Dupuis, Josee, Manichaikul, Ani, and London, Stephanie J.
Published: 2018

202. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Author: Sung, Yun J, Winkler, Thomas W, de Las Fuentes, Lisa, Bentley, Amy R, Brown, Michael R, Kraja, Aldi T, Schwander, Karen, Ntalla, Ioanna, Guo, Xiuqing, Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K, Li, Changwei, Feitosa, Mary F, Kilpeläinen, Tuomas O, Richard, Melissa A, Noordam, Raymond, Aslibekyan, Stella, Aschard, Hugues, Bartz, Traci M, Dorajoo, Rajkumar, Liu, Yongmei, Manning, Alisa K, Rankinen, Tuomo, Smith, Albert Vernon, Tajuddin, Salman M, Tayo, Bamidele O, Warren, Helen R, Zhao, Wei, Zhou, Yanhua, Matoba, Nana, Sofer, Tamar, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Giulianini, Franco, Goel, Anuj, Harris, Sarah E, Hartwig, Fernando Pires, Christensen, Kaare, Loos, Ruth J F, Sung, Yun J, Winkler, Thomas W, de Las Fuentes, Lisa, Bentley, Amy R, Brown, Michael R, Kraja, Aldi T, Schwander, Karen, Ntalla, Ioanna, Guo, Xiuqing, Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K, Li, Changwei, Feitosa, Mary F, Kilpeläinen, Tuomas O, Richard, Melissa A, Noordam, Raymond, Aslibekyan, Stella, Aschard, Hugues, Bartz, Traci M, Dorajoo, Rajkumar, Liu, Yongmei, Manning, Alisa K, Rankinen, Tuomo, Smith, Albert Vernon, Tajuddin, Salman M, Tayo, Bamidele O, Warren, Helen R, Zhao, Wei, Zhou, Yanhua, Matoba, Nana, Sofer, Tamar, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Giulianini, Franco, Goel, Anuj, Harris, Sarah E, Hartwig, Fernando Pires, Christensen, Kaare, and Loos, Ruth J F
Abstract: Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 × 10-8) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 × 10-8). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2).
Published: 2018

203. A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction.

Author: Kahali, Bratati, Yue Chen, Feitosa, Mary F., Bielak, Lawrence F., O’Connell, Jeffrey R., Musani, Solomon K., Hegde, Yash, Yanhua Chen, Stetson, L. C., Xiuqing Guo, Yi-ping Fu, Vernon Smith, Albert, Ryan, Kathleen A., Eiriksdottir, Gudny, Cohain, Ariella T., Allison, Matthew, Bakshi, Andrew, Bowden, Donald W., Budoff, Matthew J., and Carr, J. Jeffrey
Subjects: GLYCOGEN, MYOCARDIAL infarction, BLOOD cholesterol, MEDICAL sciences, LIVER, AMISH
Published: 2021
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204. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (vol 8, 80, 2017)

Author: Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltan, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Zhao, Jing Hua, Zhang, Weihua, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Ines, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Obanda, Natalia Campos, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Choi, Hyung Jin, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpelanen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Osten, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Hakan, Mellstrom, Dan, Melov, Simon, Michaelsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephen CJ, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Raikkonen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Shin, Chan Soo, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stancakova, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin MA, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Volzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances MK, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Doring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, Andre G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth JF, Karasik, David, Harris, Tamara B, Ohlsson, Claes, and Kiel, Douglas P
Published: 2017
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205. Loss of cardio-protective effects at the ADAMTS7 locus due to gene-smoking interactions

Author: Saleheen, Danish, Zhao, Wei, Young, Robin, Nelson, Christopher P., Ho, Weang Kee, Ferguson, Jane F., Rasheed, Asif, Ou, Kristy, Nurnberg, Sylvia T., Bauer, Robert C., Goel, Anuj, Do, Ron, Stewart, Alexandre F.R., Hartiala, Jaana, Zhang, Weihua, Thorleifsson, Gudmar, Strawbridge, Rona J., Sinisalo, Juha, Kanoni, Stavroula, Sedaghat, Sanaz, Marouli, Eirini, Kristiansson, Kati, Zhao, Jing Hua, Scott, Robert, Gauguier, Dominique, Shah, Svati H., Smith, Albert Vernon, Van Zuydam, Natalie, Cox, Amanda J., Willenborg, Christina, Kessler, Thorsten, Zeng, Lingyao, Province, Michael A., Ganna, Andrea, Lind, Lars, Pedersen, Nancy L., White, Charles C., Joensuu, Anni, Kleber, Marcus Edi, Hall, Alistair S., März, Winfried, Salomaa, Veikko, O'Donnell, Christopher, Ingelsson, Erik, Feitosa, Mary F., Erdmann, Jeanette, Bowden, Donald W., Palmer, Colin N.A., Gudnason, Vilmundur, de Faire, Ulf, Zalloua, Pierre, Wareham, Nicholas, Thompson, John R., Kuulasmaa, Kari, Dedoussis, George, Perola, Markus, Dehghan, Abbas, Chambers, John C., Kooner, Jaspal, Allayee, Hooman, Deloukas, Panos, McPherson, Ruth, Stefansson, Kari, Schunkert, Heribert, Kathiresan, Sekar, Farrall, Martin, Frossard, Philippe M., Rader, Daniel J., Samani, Nilesh, and Reilly, Muredach P.
Abstract: Background—Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-environment interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk.\ud \ud Methods—We analyzed data on 60,919 CHD cases and 80,243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to associate with CHD risk. We also studied 5 loci associated with smoking behavior. Study specific gene-smoking interaction effects were calculated and pooled using fixed-effects meta-analyses. Interaction analyses were declared to be significant at a P-value< 1.0x10-3 (Bonferroni correction for 50 tests).\ud \ud Results—We identified novel gene-smoking interaction for a variant upstream of the ADAMTS7 gene. Every T allele of rs7178051 was associated with lower CHD risk by 12% in never-smokers (P-value: 1.3x10-16) compared to 5% in ever-smokers (P-value: 2.5x10-4) translating to a 60% loss of CHD protection conferred by this allelic variation in people who smoked tobacco (Interaction P-value: 8.7x10-5). The protective T allele at rs7178051 was also associated with reduced ADAMTS7 expression in human aortic endothelial cells and lymphoblastoid cell lines. Exposure of human coronary artery smooth muscle cells to cigarette smoke extract led to induction of ADAMTS7.\ud \ud Conclusions—Allelic variation at rs7178051 that associates with reduced ADAMTS7 expression confers stronger CHD protection in "never-smokers" compared to "ever-smokers". Increased vascular ADAMTS7 expression may contribute to the loss of CHD protection in smokers.
Published: 2017

206. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Author: de las Fuentes, Lisa, Sung, Yun Ju, Noordam, Raymond, Winkler, Thomas, Feitosa, Mary F., Schwander, Karen, Bentley, Amy R., Brown, Michael R., Guo, Xiuqing, Manning, Alisa, Chasman, Daniel I., Aschard, Hugues, Bartz, Traci M., Bielak, Lawrence F., Campbell, Archie, Cheng, Ching-Yu, Dorajoo, Rajkumar, Hartwig, Fernando P., Horimoto, A. R. V. R., Li, Changwei, Li-Gao, Ruifang, Liu, Yongmei, Marten, Jonathan, Musani, Solomon K., Ntalla, Ioanna, Rankinen, Tuomo, Richard, Melissa, Sim, Xueling, Smith, Albert V., Tajuddin, Salman M., Tayo, Bamidele O., Vojinovic, Dina, Warren, Helen R., Xuan, Deng, Alver, Maris, Boissel, Mathilde, Chai, Jin-Fang, Chen, Xu, Christensen, Kaare, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Girotto, Giorgia, Harris, Sarah E., He, Meian, Hsu, Fang-Chi, Kühnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikäinen, Leo-Pekka, Nolte, Ilja M., Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Rueedi, Rico, Shu, Xiao-ou, Snieder, Harold, Sofer, Tamar, Takeuchi, Fumihiko, Verweij, Niek, Ware, Erin B., Weiss, Stefan, Yanek, Lisa R., Amin, Najaf, Arking, Dan E., Arnett, Donna K., Bergmann, Sven, Boerwinkle, Eric, Brody, Jennifer A., Broeckel, Ulrich, Brumat, Marco, Burke, Gregory, Cabrera, Claudia P., Canouil, Mickaël, Chee, Miao Li, Chen, Yii-Der Ida, Cocca, Massimiliano, Connell, John, de Silva, H. Janaka, de Vries, Paul S., Eiriksdottir, Gudny, Faul, Jessica D., Fisher, Virginia, Forrester, Terrence, Fox, Ervin F., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven, Ikram, M. Arfan, Irvin, Marguerite R., Kähönen, Mika, Kavousi, Maryam, Khor, Chiea Chuen, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Komulainen, Pirjo, Kraja, Aldi T., Krieger, J. E., Langefeld, Carl D., Li, Yize, Liang, Jingjing, Liewald, David C. M., Liu, Ching-Ti, Liu, Jianjun, Lohman, Kurt K., Mägi, Reedik, McKenzie, Colin A., Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mook-Kanamori, Dennis O., Nalls, Mike A., Nelson, Christopher P., Norris, Jill M., O’Connell, Jeff, Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmer, Nicholette D., Pedersen, Nancy L., Perls, Thomas, Peters, Annette, Petersmann, Astrid, Peyser, Patricia A., Polasek, Ozren, Porteous, David J., Raffel, Leslie J., Rice, Treva K., Rotter, Jerome I., Rudan, Igor, Rueda-Ochoa, Oscar-Leonel, Sabanayagam, Charumathi, Salako, Babatunde L., Schreiner, Pamela J., Shikany, James M., Sidney, Stephen S., Sims, Mario, Sitlani, Colleen M., Smith, Jennifer A., Starr, John M., Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Tham, Yih Chung, Uitterlinden, André G., Vaidya, Dhananjay, van der Ende, M. Yldau, Waldenberger, Melanie, Wang, Lihua, Wang, Ya-Xing, Wei, Wen-Bin, Weir, David R., Wen, Wanqing, Yao, Jie, Yu, Bing, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Bowden, Donald W., Deary, Ian J., Dörr, Marcus, Esko, Tõnu, Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Jonas, Jost Bruno, Kammerer, Candace M., Kato, Norihiro, Lakka, Timo A., Leander, Karin, Lehtimäki, Terho, Magnusson, Patrik K. E., Marques-Vidal, Pedro, Penninx, Brenda W. J. H., Samani, Nilesh J., van der Harst, Pim, Wagenknecht, Lynne E., Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Bouchard, Claude, Cooper, Richard S., Correa, Adolfo, Evans, Michele K., Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L., Kelly, Tanika N., Kritchevsky, Stephen B., Levy, Daniel, Palmas, Walter R., Pereira, A. C., Province, Michael M., Psaty, Bruce M., Ridker, Paul M., Rotimi, Charles N., Tai, E. Shyong, van Dam, Rob M., van Duijn, Cornelia M., Wong, Tien Yin, Rice, Kenneth, Gauderman, W. James, Morrison, Alanna C., North, Kari E., Kardia, Sharon L. R., Caulfield, Mark J., Elliott, Paul, Munroe, Patricia B., Franks, Paul W., Rao, Dabeeru C., and Fornage, Myriam
Abstract: Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N= 117 438) and follow-up on promising variants in Stage 2 studies (N= 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P< 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.
Published: 2021
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207. Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

Author: Hahn, Julie, Fu, Yi-Ping, Brown, Michael R., Bis, Joshua C., de Vries, Paul S., Feitosa, Mary F., Yanek, Lisa R., Weiss, Stefan, Giulianini, Franco, Smith, Albert Vernon, Guo, Xiuqing, Bartz, Traci M., Becker, Diane M., Becker, Lewis C., Boerwinkle, Eric, Brody, Jennifer A., Chen, Yii-Der Ida, Franco, Oscar H., Grove, Megan, and Harris, Tamara B.
Subjects: CORONARY disease, CARDIAC research, ETIOLOGY of diseases, EPIDEMIOLOGICAL research, HEART diseases
Abstract: Background: Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. To overcome the limited scope that common variants provide, we focused our investigation on low-frequency and rare sequence variations primarily residing in coding regions of the genome. Methods and results: Using samples of individuals of European ancestry from ten cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, both cross-sectional and prospective analyses were conducted to examine associations between genetic variants and myocardial infarction (MI), coronary heart disease (CHD), and all-cause mortality following these events. For prevalent events, a total of 27,349 participants of European ancestry, including 1831 prevalent MI cases and 2518 prevalent CHD cases were used. For incident cases, a total of 55,736 participants of European ancestry were included (3,031 incident MI cases and 5,425 incident CHD cases). There were 1,860 all-cause deaths among the 3,751 MI and CHD cases from six cohorts that contributed to the analysis of all-cause mortality. Single variant and gene-based analyses were performed separately in each cohort and then meta-analyzed for each outcome. A low-frequency intronic variant (rs988583) in PLCL1 was significantly associated with prevalent MI (OR = 1.80, 95% confidence interval: 1.43, 2.27; P = 7.12 × 10−7). We conducted gene-based burden tests for genes with a cumulative minor allele count (cMAC) ≥ 5 and variants with minor allele frequency (MAF) < 5%. TMPRSS5 and LDLRAD1 were significantly associated with prevalent MI and CHD, respectively, and RC3H2 and ANGPTL4 were significantly associated with incident MI and CHD, respectively. No loci were significantly associated with all-cause mortality following a MI or CHD event. Conclusion: This study identified one known locus (ANGPTL4) and four new loci (PLCL1, RC3H2, TMPRSS5, and LDLRAD1) associated with cardiovascular disease risk that warrant further investigation. [ABSTRACT FROM AUTHOR]
Published: 2020
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208. Deriving stratified effects from joint models investigating gene-environment interactions.

Author: Laville, Vincent, Majarian, Timothy, de Vries, Paul S., Bentley, Amy R., Feitosa, Mary F., Sung, Yun J., Rao, D. C., Manning, Alisa, and Aschard, Hugues
Subjects: ENVIRONMENTAL exposure, FUNCTIONAL analysis, PYTHON programming language, CONSORTIA, GENOTYPE-environment interaction
Abstract: Background: Models including an interaction term and performing a joint test of SNP and/or interaction effect are often used to discover Gene-Environment (GxE) interactions. When the environmental exposure is a binary variable, analyses from exposure-stratified models which consist of estimating genetic effect in unexposed and exposed individuals separately can be of interest. In large-scale consortia focusing on GxE interactions in which only the joint test has been performed, it may be challenging to get summary statistics from both exposure-stratified and marginal (i.e not accounting for interaction) models. Results: In this work, we developed a simple framework to estimate summary statistics in each stratum of a binary exposure and in the marginal model using summary statistics from the "joint" model. We performed simulation studies to assess our estimators' accuracy and examined potential sources of bias, such as correlation between genotype and exposure and differing phenotypic variances within exposure strata. Results from these simulations highlight the high theoretical accuracy of our estimators and yield insights into the impact of potential sources of bias. We then applied our methods to real data and demonstrate our estimators' retained accuracy after filtering SNPs by sample size to mitigate potential bias. Conclusions: These analyses demonstrated the accuracy of our method in estimating both stratified and marginal summary statistics from a joint model of gene-environment interaction. In addition to facilitating the interpretation of GxE screenings, this work could be used to guide further functional analyses. We provide a user-friendly Python script to apply this strategy to real datasets. The Python script and documentation are available at https://gitlab.pasteur.fr/statistical-genetics/j2s. [ABSTRACT FROM AUTHOR]
Published: 2020
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209. Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.

Author: Wu, Peitao, Rybin, Denis, Bielak, Lawrence F., Feitosa, Mary F., Franceschini, Nora, Li, Yize, Lu, Yingchang, Marten, Jonathan, Musani, Solomon K., Noordam, Raymond, Raghavan, Sridharan, Rose, Lynda M., Schwander, Karen, Smith, Albert V., Tajuddin, Salman M., Vojinovic, Dina, Amin, Najaf, Arnett, Donna K., Bottinger, Erwin P., and Demirkan, Ayse
Subjects: TYPE 2 diabetes, GERMPLASM, GLUCOSE, CARDIAC research, LOCUS (Genetics)
Abstract: Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies from the Cohorts for Heart Aging Research in Genomic Epidemiology Consortium (n = 74,584). In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p<1x10-7 (adjusted for multiple hypothesis-testing with the IBC array). Two SNPs had significant joint effects in the overall model and significant main effects only in one smoking stratum: rs140637 (FBN1) in AA individuals had a significant main effect only among smokers, and rs1444261 (closest gene C2orf63) in EA individuals had a significant main effect only among nonsmokers. Three additional SNPs were identified as having potential interaction by exhibiting a significant main effects only in smokers: rs1801232 (CUBN) in AA individuals, rs12243326 (TCF7L2) in EA individuals, and rs4132670 (TCF7L2) in EA individuals. No SNP met significance for potential interaction with smoking on baseline FG. The identification of these loci provides evidence for genetic interactions with smoking exposure that may explain some of the heterogeneity in the association between smoking and T2D. [ABSTRACT FROM AUTHOR]
Published: 2020
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210. Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study.

Author: Santanasto, Adam J, Marron, Megan M, Boudreau, Robert M, Feitosa, Mary F, Wojczynski, Mary K, Arbeev, Konstantin G, Thyagarajan, Bharat, Schupf, Nicole, Stallard, Eric, Sebastiani, Paola, Cosentino, Stephanie, Christensen, Kaare, and Newman, Anne B
Subjects: LONGEVITY, MINI-Mental State Examination, FAMILIES, GENERALIZED estimating equations, WAIST circumference, BODY weight, RESEARCH, RESEARCH methodology, ACTIVITIES of daily living, COGNITION, DISEASE incidence, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, DISEASE prevalence, RESEARCH funding, PEOPLE with disabilities
Abstract: Background: The Long Life Family Study (LLFS) enrolled families exhibiting exceptional longevity. The goal of this article was to determine the prevalence and predictors of remaining independent after 7 years in the oldest generation.Methods: We examined 7-year change in physical (free of activities of daily living difficulty), cognitive (Mini-Mental State Examination score ≥ 24), and overall independence (physically/cognitively independent) in adults aged 90.3 ± 6.3 from LLFS's oldest generation. Potential predictors (n = 28) of remaining independent included demographics, diseases, biomarkers, anthropometrics, and physical and cognitive performance tasks and were determined using generalized estimating equations (α: p < .05). This was a discovery/exploratory analysis, so no multiple testing correction was employed and the results require independent replication.Results: At baseline (n = 1442), 67.3%, 83.8%, and 79.7% were overall, physically, and cognitively independent, respectively. After 7 years, 66% died, 7.5% were lost to follow-up, and the prevalence of overall independence decreased to 59.1% in survivors (-8.2%, 95% confidence interval: -14.1%, 2.2%). Of those with baseline independence, 156/226 (69.0%) remained independent. Predictors of remaining physically independent included younger age, better Short Physical Performance Battery score and lung function, smaller waist circumference, and lower soluble receptor for advanced glycation end-product levels (p < .05). Predictors of remaining cognitively independent included no cancer history, better Digit Symbol Substitution Test performance, and higher body weight (p < .05).Conclusions: The prevalence of independence decreased by only 8.2% after 7 years, demonstrating the close correspondence between disability and mortality. Further, despite a mean baseline age of 90 years, a large proportion of survivors remained independent, suggesting this exceptional subgroup may harbor protective mechanisms. [ABSTRACT FROM AUTHOR]
Published: 2020
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211. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Author: Ligthart, Symen, primary, Vaez, Ahmad, additional, Võsa, Urmo, additional, Stathopoulou, Maria G., additional, de Vries, Paul S., additional, Prins, Bram P., additional, Van der Most, Peter J., additional, Tanaka, Toshiko, additional, Naderi, Elnaz, additional, Rose, Lynda M., additional, Wu, Ying, additional, Karlsson, Robert, additional, Barbalic, Maja, additional, Lin, Honghuang, additional, Pool, René, additional, Zhu, Gu, additional, Macé, Aurélien, additional, Sidore, Carlo, additional, Trompet, Stella, additional, Mangino, Massimo, additional, Sabater-Lleal, Maria, additional, Kemp, John P., additional, Abbasi, Ali, additional, Kacprowski, Tim, additional, Verweij, Niek, additional, Smith, Albert V., additional, Huang, Tao, additional, Marzi, Carola, additional, Feitosa, Mary F., additional, Lohman, Kurt K., additional, Kleber, Marcus E., additional, Milaneschi, Yuri, additional, Mueller, Christian, additional, Huq, Mahmudul, additional, Vlachopoulou, Efthymia, additional, Lyytikäinen, Leo-Pekka, additional, Oldmeadow, Christopher, additional, Deelen, Joris, additional, Perola, Markus, additional, Zhao, Jing Hua, additional, Feenstra, Bjarke, additional, Amini, Marzyeh, additional, Lahti, Jari, additional, Schraut, Katharina E., additional, Fornage, Myriam, additional, Suktitipat, Bhoom, additional, Chen, Wei-Min, additional, Li, Xiaohui, additional, Nutile, Teresa, additional, Malerba, Giovanni, additional, Luan, Jian’an, additional, Bak, Tom, additional, Schork, Nicholas, additional, Del Greco M., Fabiola, additional, Thiering, Elisabeth, additional, Mahajan, Anubha, additional, Marioni, Riccardo E., additional, Mihailov, Evelin, additional, Eriksson, Joel, additional, Ozel, Ayse Bilge, additional, Zhang, Weihua, additional, Nethander, Maria, additional, Cheng, Yu-Ching, additional, Aslibekyan, Stella, additional, Ang, Wei, additional, Gandin, Ilaria, additional, Yengo, Loïc, additional, Portas, Laura, additional, Kooperberg, Charles, additional, Hofer, Edith, additional, Rajan, Kumar B., additional, Schurmann, Claudia, additional, den Hollander, Wouter, additional, Ahluwalia, Tarunveer S., additional, Zhao, Jing, additional, Draisma, Harmen H.M., additional, Ford, Ian, additional, Timpson, Nicholas, additional, Teumer, Alexander, additional, Huang, Hongyan, additional, Wahl, Simone, additional, Liu, YongMei, additional, Huang, Jie, additional, Uh, Hae-Won, additional, Geller, Frank, additional, Joshi, Peter K., additional, Yanek, Lisa R., additional, Trabetti, Elisabetta, additional, Lehne, Benjamin, additional, Vozzi, Diego, additional, Verbanck, Marie, additional, Biino, Ginevra, additional, Saba, Yasaman, additional, Meulenbelt, Ingrid, additional, O’Connell, Jeff R., additional, Laakso, Markku, additional, Giulianini, Franco, additional, Magnusson, Patrik K.E., additional, Ballantyne, Christie M., additional, Hottenga, Jouke Jan, additional, Montgomery, Grant W., additional, Rivadineira, Fernando, additional, Rueedi, Rico, additional, Steri, Maristella, additional, Herzig, Karl-Heinz, additional, Stott, David J., additional, Menni, Cristina, additional, Frånberg, Mattias, additional, St. Pourcain, Beate, additional, Felix, Stephan B., additional, Pers, Tune H., additional, Bakker, Stephan J.L., additional, Kraft, Peter, additional, Peters, Annette, additional, Vaidya, Dhananjay, additional, Delgado, Graciela, additional, Smit, Johannes H., additional, Großmann, Vera, additional, Sinisalo, Juha, additional, Seppälä, Ilkka, additional, Williams, Stephen R., additional, Holliday, Elizabeth G., additional, Moed, Matthijs, additional, Langenberg, Claudia, additional, Räikkönen, Katri, additional, Ding, Jingzhong, additional, Campbell, Harry, additional, Sale, Michele M., additional, Chen, Yii-Der I., additional, James, Alan L., additional, Ruggiero, Daniela, additional, Soranzo, Nicole, additional, Hartman, Catharina A., additional, Smith, Erin N., additional, Berenson, Gerald S., additional, Fuchsberger, Christian, additional, Hernandez, Dena, additional, Tiesler, Carla M.T., additional, Giedraitis, Vilmantas, additional, Liewald, David, additional, Fischer, Krista, additional, Mellström, Dan, additional, Larsson, Anders, additional, Wang, Yunmei, additional, Scott, William R., additional, Lorentzon, Matthias, additional, Beilby, John, additional, Ryan, Kathleen A., additional, Pennell, Craig E., additional, Vuckovic, Dragana, additional, Balkau, Beverly, additional, Concas, Maria Pina, additional, Schmidt, Reinhold, additional, Mendes de Leon, Carlos F., additional, Bottinger, Erwin P., additional, Kloppenburg, Margreet, additional, Paternoster, Lavinia, additional, Boehnke, Michael, additional, Musk, A.W., additional, Willemsen, Gonneke, additional, Evans, David M., additional, Madden, Pamela A.F., additional, Kähönen, Mika, additional, Kutalik, Zoltán, additional, Zoledziewska, Magdalena, additional, Karhunen, Ville, additional, Kritchevsky, Stephen B., additional, Sattar, Naveed, additional, Lachance, Genevieve, additional, Clarke, Robert, additional, Harris, Tamara B., additional, Raitakari, Olli T., additional, Attia, John R., additional, van Heemst, Diana, additional, Kajantie, Eero, additional, Sorice, Rossella, additional, Gambaro, Giovanni, additional, Scott, Robert A., additional, Hicks, Andrew A., additional, Ferrucci, Luigi, additional, Standl, Marie, additional, Lindgren, Cecilia M., additional, Starr, John M., additional, Karlsson, Magnus, additional, Lind, Lars, additional, Li, Jun Z., additional, Chambers, John C., additional, Mori, Trevor A., additional, de Geus, Eco J.C.N., additional, Heath, Andrew C., additional, Martin, Nicholas G., additional, Auvinen, Juha, additional, Buckley, Brendan M., additional, de Craen, Anton J.M., additional, Waldenberger, Melanie, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Scott, Rodney J., additional, McEvoy, Mark, additional, Beekman, Marian, additional, Bombieri, Cristina, additional, Ridker, Paul M., additional, Mohlke, Karen L., additional, Pedersen, Nancy L., additional, Morrison, Alanna C., additional, Boomsma, Dorret I., additional, Whitfield, John B., additional, Strachan, David P., additional, Hofman, Albert, additional, Vollenweider, Peter, additional, Cucca, Francesco, additional, Jarvelin, Marjo-Riitta, additional, Jukema, J. Wouter, additional, Spector, Tim D., additional, Hamsten, Anders, additional, Zeller, Tanja, additional, Uitterlinden, André G., additional, Nauck, Matthias, additional, Gudnason, Vilmundur, additional, Qi, Lu, additional, Grallert, Harald, additional, Borecki, Ingrid B., additional, Rotter, Jerome I., additional, März, Winfried, additional, Wild, Philipp S., additional, Lokki, Marja-Liisa, additional, Boyle, Michael, additional, Salomaa, Veikko, additional, Melbye, Mads, additional, Eriksson, Johan G., additional, Wilson, James F., additional, Penninx, Brenda W.J.H., additional, Becker, Diane M., additional, Worrall, Bradford B., additional, Gibson, Greg, additional, Krauss, Ronald M., additional, Ciullo, Marina, additional, Zaza, Gianluigi, additional, Wareham, Nicholas J., additional, Oldehinkel, Albertine J., additional, Palmer, Lyle J., additional, Murray, Sarah S., additional, Pramstaller, Peter P., additional, Bandinelli, Stefania, additional, Heinrich, Joachim, additional, Ingelsson, Erik, additional, Deary, Ian J., additional, Mägi, Reedik, additional, Vandenput, Liesbeth, additional, van der Harst, Pim, additional, Desch, Karl C., additional, Kooner, Jaspal S., additional, Ohlsson, Claes, additional, Hayward, Caroline, additional, Lehtimäki, Terho, additional, Shuldiner, Alan R., additional, Arnett, Donna K., additional, Beilin, Lawrence J., additional, Robino, Antonietta, additional, Froguel, Philippe, additional, Pirastu, Mario, additional, Jess, Tine, additional, Koenig, Wolfgang, additional, Loos, Ruth J.F., additional, Evans, Denis A., additional, Schmidt, Helena, additional, Smith, George Davey, additional, Slagboom, P. Eline, additional, Eiriksdottir, Gudny, additional, Morris, Andrew P., additional, Psaty, Bruce M., additional, Tracy, Russell P., additional, Nolte, Ilja M., additional, Boerwinkle, Eric, additional, Visvikis-Siest, Sophie, additional, Reiner, Alex P., additional, Gross, Myron, additional, Bis, Joshua C., additional, Franke, Lude, additional, Franco, Oscar H., additional, Benjamin, Emelia J., additional, Chasman, Daniel I., additional, Dupuis, Josée, additional, Snieder, Harold, additional, Dehghan, Abbas, additional, Alizadeh, Behrooz Z., additional, Boezen, H. Marike, additional, Navis, Gerjan, additional, Rots, Marianne, additional, Swertz, Morris, additional, Wolffenbuttel, Bruce H.R., additional, Wijmenga, Cisca, additional, Benjamin, Emelia, additional, Ahluwalia, Tarunveer Singh, additional, Meigs, James, additional, Tracy, Russell, additional, Ligthart, Symen, additional, Bis, Josh, additional, Pankratz, Nathan, additional, Rainer, Alex, additional, Wilson, James G., additional, Dupuis, Josee, additional, Prins, Bram, additional, Vaso, Urmo, additional, Stathopoulou, Maria, additional, Lehtimaki, Terho, additional, Jamshidi, Yalda, additional, Siest, Sophie, additional, Uitterlinden, Andre G., additional, Abdollahi, Mohammadreza, additional, Schnabel, Renate, additional, Schick, Ursula M., additional, Kraja, Aldi, additional, Hsu, Yi-Hsiang, additional, Tylee, Daniel S., additional, Zwicker, Alyson, additional, Uher, Rudolf, additional, Davey-Smith, George, additional, Hicks, Andrew, additional, van Duijn, Cornelia M., additional, Ward-Caviness, Cavin, additional, Rotter, J., additional, Rice, Ken, additional, Lange, Leslie, additional, de Geus, Eco, additional, Makela, Kari Matti, additional, Stacey, David, additional, Eriksson, Johan, additional, Frayling, Tim M., additional, and Slagboom, Eline P., additional
Published: 2018
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212. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Author: Wyss, Annah B., primary, Sofer, Tamar, additional, Lee, Mi Kyeong, additional, Terzikhan, Natalie, additional, Nguyen, Jennifer N., additional, Lahousse, Lies, additional, Latourelle, Jeanne C., additional, Smith, Albert Vernon, additional, Bartz, Traci M., additional, Feitosa, Mary F., additional, Gao, Wei, additional, Ahluwalia, Tarunveer S., additional, Tang, Wenbo, additional, Oldmeadow, Christopher, additional, Duan, Qing, additional, de Jong, Kim, additional, Wojczynski, Mary K., additional, Wang, Xin-Qun, additional, Noordam, Raymond, additional, Hartwig, Fernando Pires, additional, Jackson, Victoria E., additional, Wang, Tianyuan, additional, Obeidat, Ma’en, additional, Hobbs, Brian D., additional, Huan, Tianxiao, additional, Gui, Hongsheng, additional, Parker, Margaret M., additional, Hu, Donglei, additional, Mogil, Lauren S., additional, Kichaev, Gleb, additional, Jin, Jianping, additional, Graff, Mariaelisa, additional, Harris, Tamara B., additional, Kalhan, Ravi, additional, Heckbert, Susan R., additional, Paternoster, Lavinia, additional, Burkart, Kristin M., additional, Liu, Yongmei, additional, Holliday, Elizabeth G., additional, Wilson, James G., additional, Vonk, Judith M., additional, Sanders, Jason L., additional, Barr, R. Graham, additional, de Mutsert, Renée, additional, Menezes, Ana Maria Baptista, additional, Adams, Hieab H. H., additional, van den Berge, Maarten, additional, Joehanes, Roby, additional, Levin, Albert M., additional, Liberto, Jennifer, additional, Launer, Lenore J., additional, Morrison, Alanna C., additional, Sitlani, Colleen M., additional, Celedón, Juan C., additional, Kritchevsky, Stephen B., additional, Scott, Rodney J., additional, Christensen, Kaare, additional, Rotter, Jerome I., additional, Bonten, Tobias N., additional, Wehrmeister, Fernando César, additional, Bossé, Yohan, additional, Xiao, Shujie, additional, Oh, Sam, additional, Franceschini, Nora, additional, Brody, Jennifer A., additional, Kaplan, Robert C., additional, Lohman, Kurt, additional, McEvoy, Mark, additional, Province, Michael A., additional, Rosendaal, Frits R., additional, Taylor, Kent D., additional, Nickle, David C., additional, Williams, L. Keoki, additional, Burchard, Esteban G., additional, Wheeler, Heather E., additional, Sin, Don D., additional, Gudnason, Vilmundur, additional, North, Kari E., additional, Fornage, Myriam, additional, Psaty, Bruce M., additional, Myers, Richard H., additional, O’Connor, George, additional, Hansen, Torben, additional, Laurie, Cathy C., additional, Cassano, Patricia A., additional, Sung, Joohon, additional, Kim, Woo Jin, additional, Attia, John R., additional, Lange, Leslie, additional, Boezen, H. Marike, additional, Thyagarajan, Bharat, additional, Rich, Stephen S., additional, Mook-Kanamori, Dennis O., additional, Horta, Bernardo Lessa, additional, Uitterlinden, André G., additional, Im, Hae Kyung, additional, Cho, Michael H., additional, Brusselle, Guy G., additional, Gharib, Sina A., additional, Dupuis, Josée, additional, Manichaikul, Ani, additional, and London, Stephanie J., additional
Published: 2018
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213. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

Author: Merino, Jordi, primary, Dashti, Hassan S., additional, Li, Sherly X., additional, Sarnowski, Chloé, additional, Justice, Anne E., additional, Graff, Misa, additional, Papoutsakis, Constantina, additional, Smith, Caren E., additional, Dedoussis, George V., additional, Lemaitre, Rozenn N., additional, Wojczynski, Mary K., additional, Männistö, Satu, additional, Ngwa, Julius S., additional, Kho, Minjung, additional, Ahluwalia, Tarunveer S., additional, Pervjakova, Natalia, additional, Houston, Denise K., additional, Bouchard, Claude, additional, Huang, Tao, additional, Orho-Melander, Marju, additional, Frazier-Wood, Alexis C., additional, Mook-Kanamori, Dennis O., additional, Pérusse, Louis, additional, Pennell, Craig E., additional, de Vries, Paul S., additional, Voortman, Trudy, additional, Li, Olivia, additional, Kanoni, Stavroula, additional, Rose, Lynda M., additional, Lehtimäki, Terho, additional, Zhao, Jing Hua, additional, Feitosa, Mary F., additional, Luan, Jian’an, additional, McKeown, Nicola M., additional, Smith, Jennifer A., additional, Hansen, Torben, additional, Eklund, Niina, additional, Nalls, Mike A., additional, Rankinen, Tuomo, additional, Huang, Jinyan, additional, Hernandez, Dena G., additional, Schulz, Christina-Alexandra, additional, Manichaikul, Ani, additional, Li-Gao, Ruifang, additional, Vohl, Marie-Claude, additional, Wang, Carol A., additional, van Rooij, Frank J. A., additional, Shin, Jean, additional, Kalafati, Ioanna P., additional, Day, Felix, additional, Ridker, Paul M., additional, Kähönen, Mika, additional, Siscovick, David S., additional, Langenberg, Claudia, additional, Zhao, Wei, additional, Astrup, Arne, additional, Knekt, Paul, additional, Garcia, Melissa, additional, Rao, D. C., additional, Qi, Qibin, additional, Ferrucci, Luigi, additional, Ericson, Ulrika, additional, Blangero, John, additional, Hofman, Albert, additional, Pausova, Zdenka, additional, Mikkilä, Vera, additional, Wareham, Nick J., additional, Kardia, Sharon L. R, additional, Pedersen, Oluf, additional, Jula, Antti, additional, Curran, Joanne E., additional, Zillikens, M. Carola, additional, Viikari, Jorma S., additional, Forouhi, Nita G., additional, Ordovás, José M., additional, Lieske, John C., additional, Rissanen, Harri, additional, Uitterlinden, André G., additional, Raitakari, Olli T., additional, Kiefte-de Jong, Jessica C., additional, Dupuis, Josée, additional, Rotter, Jerome I., additional, North, Kari E., additional, Scott, Robert A., additional, Province, Michael A., additional, Perola, Markus, additional, Cupples, L. Adrienne, additional, Turner, Stephen T., additional, Sørensen, Thorkild I. A., additional, Salomaa, Veikko, additional, Liu, Yongmei, additional, Sung, Yun J., additional, Qi, Lu, additional, Bandinelli, Stefania, additional, Rich, Stephen S., additional, de Mutsert, Renée, additional, Tremblay, Angelo, additional, Oddy, Wendy H., additional, Franco, Oscar H., additional, Paus, Tomas, additional, Florez, Jose C., additional, Deloukas, Panos, additional, Lyytikäinen, Leo-Pekka, additional, Chasman, Daniel I., additional, Chu, Audrey Y., additional, and Tanaka, Toshiko, additional
Published: 2018
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214. An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort

Author: Geng, Xin, primary, Irvin, Marguerite R., additional, Hidalgo, Bertha, additional, Aslibekyan, Stella, additional, Srinivasasainagendra, Vinodh, additional, An, Ping, additional, Frazier-Wood, Alexis C., additional, Tiwari, Hemant K., additional, Dave, Tushar, additional, Ryan, Kathleen, additional, Ordovas, Jose M., additional, Straka, Robert J., additional, Feitosa, Mary F., additional, Hopkins, Paul N., additional, Borecki, Ingrid, additional, Province, Michael A., additional, Mitchell, Braxton D., additional, Arnett, Donna K., additional, and Zhi, Degui, additional
Published: 2018
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215. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Author: Sung, Yun J., primary, Winkler, Thomas W., additional, de las Fuentes, Lisa, additional, Bentley, Amy R., additional, Brown, Michael R., additional, Kraja, Aldi T., additional, Schwander, Karen, additional, Ntalla, Ioanna, additional, Guo, Xiuqing, additional, Franceschini, Nora, additional, Lu, Yingchang, additional, Cheng, Ching-Yu, additional, Sim, Xueling, additional, Vojinovic, Dina, additional, Marten, Jonathan, additional, Musani, Solomon K., additional, Li, Changwei, additional, Feitosa, Mary F., additional, Kilpeläinen, Tuomas O., additional, Richard, Melissa A., additional, Noordam, Raymond, additional, Aslibekyan, Stella, additional, Aschard, Hugues, additional, Bartz, Traci M., additional, Dorajoo, Rajkumar, additional, Liu, Yongmei, additional, Manning, Alisa K., additional, Rankinen, Tuomo, additional, Smith, Albert Vernon, additional, Tajuddin, Salman M., additional, Tayo, Bamidele O., additional, Warren, Helen R., additional, Zhao, Wei, additional, Zhou, Yanhua, additional, Matoba, Nana, additional, Sofer, Tamar, additional, Alver, Maris, additional, Amini, Marzyeh, additional, Boissel, Mathilde, additional, Chai, Jin Fang, additional, Chen, Xu, additional, Divers, Jasmin, additional, Gandin, Ilaria, additional, Gao, Chuan, additional, Giulianini, Franco, additional, Goel, Anuj, additional, Harris, Sarah E., additional, Hartwig, Fernando Pires, additional, Horimoto, Andrea R.V.R., additional, Hsu, Fang-Chi, additional, Jackson, Anne U., additional, Kähönen, Mika, additional, Kasturiratne, Anuradhani, additional, Kühnel, Brigitte, additional, Leander, Karin, additional, Lee, Wen-Jane, additional, Lin, Keng-Hung, additional, ’an Luan, Jian, additional, McKenzie, Colin A., additional, Meian, He, additional, Nelson, Christopher P., additional, Rauramaa, Rainer, additional, Schupf, Nicole, additional, Scott, Robert A., additional, Sheu, Wayne H.H., additional, Stančáková, Alena, additional, Takeuchi, Fumihiko, additional, van der Most, Peter J., additional, Varga, Tibor V., additional, Wang, Heming, additional, Wang, Yajuan, additional, Ware, Erin B., additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Yanek, Lisa R., additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Afaq, Saima, additional, Alfred, Tamuno, additional, Amin, Najaf, additional, Arking, Dan, additional, Aung, Tin, additional, Barr, R. Graham, additional, Bielak, Lawrence F., additional, Boerwinkle, Eric, additional, Bottinger, Erwin P., additional, Braund, Peter S., additional, Brody, Jennifer A., additional, Broeckel, Ulrich, additional, Cabrera, Claudia P., additional, Cade, Brian, additional, Caizheng, Yu, additional, Campbell, Archie, additional, Canouil, Mickaël, additional, Chakravarti, Aravinda, additional, Chauhan, Ganesh, additional, Christensen, Kaare, additional, Cocca, Massimiliano, additional, Collins, Francis S., additional, Connell, John M., additional, de Mutsert, Renée, additional, de Silva, H. Janaka, additional, Debette, Stephanie, additional, Dörr, Marcus, additional, Duan, Qing, additional, Eaton, Charles B., additional, Ehret, Georg, additional, Evangelou, Evangelos, additional, Faul, Jessica D., additional, Fisher, Virginia A., additional, Forouhi, Nita G., additional, Franco, Oscar H., additional, Friedlander, Yechiel, additional, Gao, He, additional, Gigante, Bruna, additional, Graff, Misa, additional, Gu, C. Charles, additional, Gu, Dongfeng, additional, Gupta, Preeti, additional, Hagenaars, Saskia P., additional, Harris, Tamara B., additional, He, Jiang, additional, Heikkinen, Sami, additional, Heng, Chew-Kiat, additional, Hirata, Makoto, additional, Hofman, Albert, additional, Howard, Barbara V., additional, Hunt, Steven, additional, Irvin, Marguerite R., additional, Jia, Yucheng, additional, Joehanes, Roby, additional, Justice, Anne E., additional, Katsuya, Tomohiro, additional, Kaufman, Joel, additional, Kerrison, Nicola D., additional, Khor, Chiea Chuen, additional, Koh, Woon-Puay, additional, Koistinen, Heikki A., additional, Komulainen, Pirjo, additional, Kooperberg, Charles, additional, Krieger, Jose E., additional, Kubo, Michiaki, additional, Kuusisto, Johanna, additional, Langefeld, Carl D., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Lehne, Benjamin, additional, Lewis, Cora E., additional, Li, Yize, additional, Lim, Sing Hui, additional, Lin, Shiow, additional, Liu, Ching-Ti, additional, Liu, Jianjun, additional, Liu, Jingmin, additional, Liu, Kiang, additional, Liu, Yeheng, additional, Loh, Marie, additional, Lohman, Kurt K., additional, Long, Jirong, additional, Louie, Tin, additional, Mägi, Reedik, additional, Mahajan, Anubha, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Milani, Lili, additional, Momozawa, Yukihide, additional, Morris, Andrew P., additional, Mosley, Thomas H., additional, Munson, Peter, additional, Murray, Alison D., additional, Nalls, Mike A., additional, Nasri, Ubaydah, additional, Norris, Jill M., additional, North, Kari, additional, Ogunniyi, Adesola, additional, Padmanabhan, Sandosh, additional, Palmas, Walter R., additional, Palmer, Nicholette D., additional, Pankow, James S., additional, Pedersen, Nancy L., additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Raitakari, Olli T., additional, Renström, Frida, additional, Rice, Treva K., additional, Ridker, Paul M., additional, Robino, Antonietta, additional, Robinson, Jennifer G., additional, Rose, Lynda M., additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Salako, Babatunde L., additional, Sandow, Kevin, additional, Schmidt, Carsten O., additional, Schreiner, Pamela J., additional, Scott, William R., additional, Seshadri, Sudha, additional, Sever, Peter, additional, Sitlani, Colleen M., additional, Smith, Jennifer A., additional, Snieder, Harold, additional, Starr, John M., additional, Strauch, Konstantin, additional, Tang, Hua, additional, Taylor, Kent D., additional, Teo, Yik Ying, additional, Tham, Yih Chung, additional, Uitterlinden, André G., additional, Waldenberger, Melanie, additional, Wang, Lihua, additional, Wang, Ya X., additional, Wei, Wen Bin, additional, Williams, Christine, additional, Wilson, Gregory, additional, Wojczynski, Mary K., additional, Yao, Jie, additional, Yuan, Jian-Min, additional, Zonderman, Alan B., additional, Becker, Diane M., additional, Boehnke, Michael, additional, Bowden, Donald W., additional, Chambers, John C., additional, Chen, Yii-Der Ida, additional, de Faire, Ulf, additional, Deary, Ian J., additional, Esko, Tõnu, additional, Farrall, Martin, additional, Forrester, Terrence, additional, Franks, Paul W., additional, Freedman, Barry I., additional, Froguel, Philippe, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Horta, Bernardo Lessa, additional, Hung, Yi-Jen, additional, Jonas, Jost B., additional, Kato, Norihiro, additional, Kooner, Jaspal S., additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Liang, Kae-Woei, additional, Magnusson, Patrik K.E., additional, Newman, Anne B., additional, Oldehinkel, Albertine J., additional, Pereira, Alexandre C., additional, Redline, Susan, additional, Rettig, Rainer, additional, Samani, Nilesh J., additional, Scott, James, additional, Shu, Xiao-Ou, additional, van der Harst, Pim, additional, Wagenknecht, Lynne E., additional, Wareham, Nicholas J., additional, Watkins, Hugh, additional, Weir, David R., additional, Wickremasinghe, Ananda R., additional, Wu, Tangchun, additional, Zheng, Wei, additional, Kamatani, Yoichiro, additional, Laurie, Cathy C., additional, Bouchard, Claude, additional, Cooper, Richard S., additional, Evans, Michele K., additional, Gudnason, Vilmundur, additional, Kardia, Sharon L.R., additional, Kritchevsky, Stephen B., additional, Levy, Daniel, additional, O’Connell, Jeff R., additional, Psaty, Bruce M., additional, van Dam, Rob M., additional, Sims, Mario, additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Kelly, Tanika N., additional, Fox, Ervin R., additional, Hayward, Caroline, additional, Fornage, Myriam, additional, Rotimi, Charles N., additional, Province, Michael A., additional, van Duijn, Cornelia M., additional, Tai, E. Shyong, additional, Wong, Tien Yin, additional, Loos, Ruth J.F., additional, Reiner, Alex P., additional, Rotter, Jerome I., additional, Zhu, Xiaofeng, additional, Bierut, Laura J., additional, Gauderman, W. James, additional, Caulfield, Mark J., additional, Elliott, Paul, additional, Rice, Kenneth, additional, Munroe, Patricia B., additional, Morrison, Alanna C., additional, Cupples, L. Adrienne, additional, Rao, Dabeeru C., additional, and Chasman, Daniel I., additional
Published: 2018
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216. Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Author: Smith, Caren E., primary, Follis, Jack L., additional, Dashti, Hassan S., additional, Tanaka, Toshiko, additional, Graff, Mariaelisa, additional, Fretts, Amanda M., additional, Kilpeläinen, Tuomas O., additional, Wojczynski, Mary K., additional, Richardson, Kris, additional, Nalls, Mike A., additional, Schulz, Christina-Alexandra, additional, Liu, Yongmei, additional, Frazier-Wood, Alexis C., additional, van Eekelen, Esther, additional, Wang, Carol, additional, de Vries, Paul S., additional, Mikkilä, Vera, additional, Rohde, Rebecca, additional, Psaty, Bruce M., additional, Hansen, Torben, additional, Feitosa, Mary F., additional, Lai, Chao-Qiang, additional, Houston, Denise K., additional, Ferruci, Luigi, additional, Ericson, Ulrika, additional, Wang, Zhe, additional, de Mutsert, Renée, additional, Oddy, Wendy H., additional, de Jonge, Ester A. L., additional, Seppälä, Ilkka, additional, Justice, Anne E., additional, Lemaitre, Rozenn N., additional, Sørensen, Thorkild I. A., additional, Province, Michael A., additional, Parnell, Laurence D., additional, Garcia, Melissa E., additional, Bandinelli, Stefania, additional, Orho-Melander, Marju, additional, Rich, Stephen S., additional, Rosendaal, Frits R., additional, Pennell, Craig E., additional, Kiefte-de Jong, Jessica C., additional, Kähönen, Mika, additional, Young, Kristin L., additional, Pedersen, Oluf, additional, Aslibekyan, Stella, additional, Rotter, Jerome I., additional, Mook-Kanamori, Dennis O., additional, Zillikens, M. Carola, additional, Raitakari, Olli T., additional, North, Kari E., additional, Overvad, Kim, additional, Arnett, Donna K., additional, Hofman, Albert, additional, Lehtimäki, Terho, additional, Tjønneland, Anne, additional, Uitterlinden, André G., additional, Rivadeneira, Fernando, additional, Franco, Oscar H., additional, German, J. Bruce, additional, Siscovick, David S., additional, Cupples, L. Adrienne, additional, and Ordovás, José M., additional
Published: 2017
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217. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Author: Gorski, Mathias, Jung, Bettina, Li, Yong, Matias-Garcia, Pamela R., Wuttke, Matthias, Coassin, Stefan, Thio, Chris H.L., Kleber, Marcus E., Winkler, Thomas W., Wanner, Veronika, Chai, Jin-Fang, Chu, Audrey Y., Cocca, Massimiliano, Feitosa, Mary F., Ghasemi, Sahar, Hoppmann, Anselm, Horn, Katrin, Li, Man, Nutile, Teresa, Scholz, Markus, Sieber, Karsten B., Teumer, Alexander, Tin, Adrienne, Wang, Judy, Tayo, Bamidele O., Ahluwalia, Tarunveer S., Almgren, Peter, Bakker, Stephan J.L., Banas, Bernhard, Bansal, Nisha, Biggs, Mary L., Boerwinkle, Eric, Bottinger, Erwin P., Brenner, Hermann, Carroll, Robert J., Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Coresh, Josef, de Borst, Martin H., Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Franke, Andre, Freitag-Wolf, Sandra, Gampawar, Piyush, Gansevoort, Ron T., Ghanbari, Mohsen, Gieger, Christian, Hamet, Pavel, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Xian Foo, Valencia Hui, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M. Arfan, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kühnel, Brigitte, Lange, Leslie A., Lehtimäki, Terho, Lieb, Wolfgang, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Snieder, Harold, Swertz, Morris, Wolffenbuttel, Bruce H.R., Wijmenga, Cisca, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Overton, John D., Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Reid, Jeffrey G., Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mitnaul, Lyndon J., Loos, Ruth J.F., Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Mychaleckyj, Josyf C., Nadkarni, Girish N., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., O’Donoghue, Michelle L., Orho-Melander, Marju, Pendergrass, Sarah A., Penninx, Brenda W.J.H., Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Raitakari, Olli T., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Rosenkranz, Alexander R., Rossing, Peter, Rotter, Jerome I., Sabanayagam, Charumathi, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Sedaghat, Sanaz, Shaffer, Christian M., Strauch, Konstantin, Szymczak, Silke, Taylor, Kent D., Tremblay, Johanne, Chaker, Layal, van der Harst, Pim, van der Most, Peter J., Verweij, Niek, Völker, Uwe, Waldenberger, Melanie, Wallentin, Lars, Waterworth, Dawn M., White, Harvey D., Wilson, James G., Wong, Tien-Yin, Woodward, Mark, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M., Zhang, Yan, Snieder, Harold, Wanner, Christoph, Böger, Carsten A., Köttgen, Anna, Kronenberg, Florian, Pattaro, Cristian, and Heid, Iris M.
Abstract: Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more (“Rapid3”; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2at follow-up among those with eGFRcrea 60 mL/min/1.73m2or more at baseline (“CKDi25”; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT(2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATMor LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Published: 2021
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218. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author: Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltyn, Luan, Jian'an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Zhao, Jing Hua, Zhang, Weihua, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Ines, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Obanda, Natalia Campos, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Choi, Hyung Jin, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpainen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellstrom, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O'Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephan, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Raikkonen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Shin, Chan Soo, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stancakova, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Voelzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichman, H. -Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Doring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, Andre G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P., Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltyn, Luan, Jian'an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Zhao, Jing Hua, Zhang, Weihua, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Ines, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Obanda, Natalia Campos, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Choi, Hyung Jin, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpainen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellstrom, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O'Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephan, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Raikkonen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Shin, Chan Soo, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stancakova, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Voelzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichman, H. -Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Doring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, Andre G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, and Kiel, Douglas P.
Abstract: Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 x 10(-8)) or suggestively genome wide (p < 2.3 x 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/ near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/ near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass., Correction in: Nature Communications, Vol. 8, issue 1, artikel-id 1414DOI: 10.1038/s41467-017-01008-2
Published: 2017
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219. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author: Justice, Anne E, Winkler, Thomas W, Feitosa, Mary F, Graff, Misa, Fisher, Virginia A, Young, Kristin, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S, Ahluwalia, Tarunveer S, Chu, Audrey Y, Heard-Costa, Nancy L, Lim, Elise, Perez, Jeremiah, Eicher, John D, Kutalik, Zoltan, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph, Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F, Bonnefond, Amelie, Bragg, Jennifer, Cadby, Gemma, Chittani, Martina, Coggeshall, Scott, Corre, Tanguy, Direk, Nese, Eriksson, Joel, Fischer, Krista, Gorski, Mathias, Neergaard Harder, Marie, Horikoshi, Momoko, Huang, Tao, Huffman, Jennifer E, Jackson, Anne U, Justesen, Johanne Marie, Kanoni, Stavroula, Kinnunen, Leena, Kleber, Marcus E, Komulainen, Pirjo, Kumari, Meena, Lim, Unhee, Luan, Jian'an, Lyytikainen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Middelberg, Rita P S, Muller-Nurasyid, Martina, Navarro, Pau, Perusse, Louis, Pervjakova, Natalia, Sarti, Cinzia, Smith, Albert Vernon, Smith, Jennifer A, Stancakova, Alena, Strawbridge, Rona J, Stringham, Heather M, Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W, van der Most, Peter J, Van Vliet-Ostaptchouk, Jana V, Vedantam, Sailaja L, Verweij, Niek, Vink, Jacqueline M, Vitart, Veronique, Wu, Ying, Yengo, Loic, Zhang, Weihua, Hua Zhao, Jing, Zimmermann, Martina E, Zubair, Niha, Abecasis, Goncalo R, Adair, Linda S, Afaq, Saima, Afzal, Uzma, Bakker, Stephan J L, Bartz, Traci M, Beilby, John, Bergman, Richard N, Bergmann, Sven, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L, Bottinger, Erwin, Braga, Daniele, Buckley, Brendan M, Buyske, Steve, Campbell, Harry, Chambers, John C, Collins, Francis S, Curran, Joanne E, de Borst, Gert J, de Craen, Anton J M, de Geus, Eco J C, Dedoussis, George, Delgado, Graciela E, den Ruijter, Hester M, Eiriksdottir, Gudny, Eriksson, Anna L, Esko, Tonu, Faul, Jessica D, Ford, Ian, Forrester, Terrence, Gertow, Karl, Gigante, Bruna, Glorioso, Nicola, Gong, Jian, Grallert, Harald, Grammer, Tanja B, Grarup, Niels, Haitjema, Saskia, Hallmans, Göran, Hamsten, Anders, Hansen, Torben, Harris, Tamara B, Hartman, Catharina A, Hassinen, Maija, Hastie, Nicholas D, Heath, Andrew C, Hernandez, Dena, Hindorff, Lucia, Hocking, Lynne J, Hollensted, Mette, Holmen, Oddgeir L, Homuth, Georg, Jan Hottenga, Jouke, Huang, Jie, Hung, Joseph, Hutri-Kahonen, Nina, Ingelsson, Erik, James, Alan L, Jansson, John-Olov, Jarvelin, Marjo-Riitta, Jhun, Min A, Jorgensen, Marit E, Juonala, Markus, Kahonen, Mika, Karlsson, Magnus, Koistinen, Heikki A, Kolcic, Ivana, Kolovou, Genovefa, Kooperberg, Charles, Kramer, Bernhard K, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A, Langenberg, Claudia, Launer, Lenore J, Leander, Karin, Lee, Nanette R, Lind, Lars, Lindgren, Cecilia M, Linneberg, Allan, Lobbens, Stephane, Loh, Marie, Lorentzon, Mattias, Luben, Robert, Lubke, Gitta, Ludolph-Donislawski, Anja, Lupoli, Sara, Madden, Pamela A F, Mannikko, Reija, Marques-Vidal, Pedro, Martin, Nicholas G, McKenzie, Colin A, McKnight, Barbara, Mellstrom, Dan, Menni, Cristina, Montgomery, Grant W, Musk, Aw Bill, Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M, Oldehinkel, Albertine J, Olden, Matthias, Ong, Ken K, Padmanabhan, Sandosh, Peyser, Patricia A, Pisinger, Charlotta, Porteous, David J, Raitakari, Olli T, Rankinen, Tuomo, Rao, D C, Rasmussen-Torvik, Laura J, Rawal, Rajesh, Rice, Treva, Ridker, Paul M, Rose, Lynda M, Bien, Stephanie A, Rudan, Igor, Sanna, Serena, Sarzynski, Mark A, Sattar, Naveed, Savonen, Kai, Schlessinger, David, Scholtens, Salome, Schurmann, Claudia, Scott, Robert A, Sennblad, Bengt, Siemelink, Marten A, Silbernagel, Gunther, Slagboom, P Eline, Snieder, Harold, Staessen, Jan A, Stott, David J, Swertz, Morris A, Swift, Amy J, Taylor, Kent D, Tayo, Bamidele O, Thorand, Barbara, Thuillier, Dorothee, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vandenput, Liesbeth, Vohl, Marie-Claude, Volzke, Henry, Vonk, Judith M, Waeber, Gerard, Waldenberger, Melanie, Westendorp, R G J, Wild, Sarah, Willemsen, Gonneke, Wolffenbuttel, Bruce H R, Wong, Andrew, Wright, Alan F, Zhao, Wei, Zillikens, M Carola, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Boger, Carsten A, Boomsma, Dorret I, Bouchard, Claude, Bruinenberg, Marcel, Chasman, Daniel I, Chen, Yii-DerIda, Chines, Peter S, Cooper, Richard S, Cucca, Francesco, Cusi, Daniele, Faire, Ulf de, Ferrucci, Luigi, Franks, Paul W, Froguel, Philippe, Gordon-Larsen, Penny, Grabe, Hans-Jorgen, Gudnason, Vilmundur, Haiman, Christopher A, Hayward, Caroline, Hveem, Kristian, Johnson, Andrew D, Wouter Jukema, J, Kardia, Sharon L R, Kivimaki, Mika, Kooner, Jaspal S, Kuh, Diana, Laakso, Markku, Lehtimaki, Terho, Marchand, Loic Le, Marz, Winfried, McCarthy, Mark I, Metspalu, Andres, Morris, Andrew P, Ohlsson, Claes, Palmer, Lyle J, Pasterkamp, Gerard, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Psaty, Bruce M, Qi, Lu, Rauramaa, Rainer, Smith, Blair H, Sorensen, Thorkild I A, Strauch, Konstantin, Tiemeier, Henning, Tremoli, Elena, van der Harst, Pim, Vestergaard, Henrik, Vollenweider, Peter, Wareham, Nicholas J, Weir, David R, Whitfield, John B, Wilson, James F, Tyrrell, Jessica, Frayling, Timothy M, Barroso, Ines, Boehnke, Michael, Deloukas, Panagiotis, Fox, Caroline S, Hirschhorn, Joel N, Hunter, David J, Spector, Tim D, Strachan, David P, van Duijn, Cornelia M, Heid, Iris M, Mohlke, Karen L, Marchini, Jonathan, Loos, Ruth J F, Kilpelainen, Tuomas O, Liu, Ching-Ti, Borecki, Ingrid B, North, Kari E, Cupples, L Adrienne, Justice, Anne E, Winkler, Thomas W, Feitosa, Mary F, Graff, Misa, Fisher, Virginia A, Young, Kristin, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S, Ahluwalia, Tarunveer S, Chu, Audrey Y, Heard-Costa, Nancy L, Lim, Elise, Perez, Jeremiah, Eicher, John D, Kutalik, Zoltan, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph, Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F, Bonnefond, Amelie, Bragg, Jennifer, Cadby, Gemma, Chittani, Martina, Coggeshall, Scott, Corre, Tanguy, Direk, Nese, Eriksson, Joel, Fischer, Krista, Gorski, Mathias, Neergaard Harder, Marie, Horikoshi, Momoko, Huang, Tao, Huffman, Jennifer E, Jackson, Anne U, Justesen, Johanne Marie, Kanoni, Stavroula, Kinnunen, Leena, Kleber, Marcus E, Komulainen, Pirjo, Kumari, Meena, Lim, Unhee, Luan, Jian'an, Lyytikainen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Middelberg, Rita P S, Muller-Nurasyid, Martina, Navarro, Pau, Perusse, Louis, Pervjakova, Natalia, Sarti, Cinzia, Smith, Albert Vernon, Smith, Jennifer A, Stancakova, Alena, Strawbridge, Rona J, Stringham, Heather M, Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W, van der Most, Peter J, Van Vliet-Ostaptchouk, Jana V, Vedantam, Sailaja L, Verweij, Niek, Vink, Jacqueline M, Vitart, Veronique, Wu, Ying, Yengo, Loic, Zhang, Weihua, Hua Zhao, Jing, Zimmermann, Martina E, Zubair, Niha, Abecasis, Goncalo R, Adair, Linda S, Afaq, Saima, Afzal, Uzma, Bakker, Stephan J L, Bartz, Traci M, Beilby, John, Bergman, Richard N, Bergmann, Sven, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L, Bottinger, Erwin, Braga, Daniele, Buckley, Brendan M, Buyske, Steve, Campbell, Harry, Chambers, John C, Collins, Francis S, Curran, Joanne E, de Borst, Gert J, de Craen, Anton J M, de Geus, Eco J C, Dedoussis, George, Delgado, Graciela E, den Ruijter, Hester M, Eiriksdottir, Gudny, Eriksson, Anna L, Esko, Tonu, Faul, Jessica D, Ford, Ian, Forrester, Terrence, Gertow, Karl, Gigante, Bruna, Glorioso, Nicola, Gong, Jian, Grallert, Harald, Grammer, Tanja B, Grarup, Niels, Haitjema, Saskia, Hallmans, Göran, Hamsten, Anders, Hansen, Torben, Harris, Tamara B, Hartman, Catharina A, Hassinen, Maija, Hastie, Nicholas D, Heath, Andrew C, Hernandez, Dena, Hindorff, Lucia, Hocking, Lynne J, Hollensted, Mette, Holmen, Oddgeir L, Homuth, Georg, Jan Hottenga, Jouke, Huang, Jie, Hung, Joseph, Hutri-Kahonen, Nina, Ingelsson, Erik, James, Alan L, Jansson, John-Olov, Jarvelin, Marjo-Riitta, Jhun, Min A, Jorgensen, Marit E, Juonala, Markus, Kahonen, Mika, Karlsson, Magnus, Koistinen, Heikki A, Kolcic, Ivana, Kolovou, Genovefa, Kooperberg, Charles, Kramer, Bernhard K, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A, Langenberg, Claudia, Launer, Lenore J, Leander, Karin, Lee, Nanette R, Lind, Lars, Lindgren, Cecilia M, Linneberg, Allan, Lobbens, Stephane, Loh, Marie, Lorentzon, Mattias, Luben, Robert, Lubke, Gitta, Ludolph-Donislawski, Anja, Lupoli, Sara, Madden, Pamela A F, Mannikko, Reija, Marques-Vidal, Pedro, Martin, Nicholas G, McKenzie, Colin A, McKnight, Barbara, Mellstrom, Dan, Menni, Cristina, Montgomery, Grant W, Musk, Aw Bill, Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M, Oldehinkel, Albertine J, Olden, Matthias, Ong, Ken K, Padmanabhan, Sandosh, Peyser, Patricia A, Pisinger, Charlotta, Porteous, David J, Raitakari, Olli T, Rankinen, Tuomo, Rao, D C, Rasmussen-Torvik, Laura J, Rawal, Rajesh, Rice, Treva, Ridker, Paul M, Rose, Lynda M, Bien, Stephanie A, Rudan, Igor, Sanna, Serena, Sarzynski, Mark A, Sattar, Naveed, Savonen, Kai, Schlessinger, David, Scholtens, Salome, Schurmann, Claudia, Scott, Robert A, Sennblad, Bengt, Siemelink, Marten A, Silbernagel, Gunther, Slagboom, P Eline, Snieder, Harold, Staessen, Jan A, Stott, David J, Swertz, Morris A, Swift, Amy J, Taylor, Kent D, Tayo, Bamidele O, Thorand, Barbara, Thuillier, Dorothee, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vandenput, Liesbeth, Vohl, Marie-Claude, Volzke, Henry, Vonk, Judith M, Waeber, Gerard, Waldenberger, Melanie, Westendorp, R G J, Wild, Sarah, Willemsen, Gonneke, Wolffenbuttel, Bruce H R, Wong, Andrew, Wright, Alan F, Zhao, Wei, Zillikens, M Carola, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Boger, Carsten A, Boomsma, Dorret I, Bouchard, Claude, Bruinenberg, Marcel, Chasman, Daniel I, Chen, Yii-DerIda, Chines, Peter S, Cooper, Richard S, Cucca, Francesco, Cusi, Daniele, Faire, Ulf de, Ferrucci, Luigi, Franks, Paul W, Froguel, Philippe, Gordon-Larsen, Penny, Grabe, Hans-Jorgen, Gudnason, Vilmundur, Haiman, Christopher A, Hayward, Caroline, Hveem, Kristian, Johnson, Andrew D, Wouter Jukema, J, Kardia, Sharon L R, Kivimaki, Mika, Kooner, Jaspal S, Kuh, Diana, Laakso, Markku, Lehtimaki, Terho, Marchand, Loic Le, Marz, Winfried, McCarthy, Mark I, Metspalu, Andres, Morris, Andrew P, Ohlsson, Claes, Palmer, Lyle J, Pasterkamp, Gerard, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Psaty, Bruce M, Qi, Lu, Rauramaa, Rainer, Smith, Blair H, Sorensen, Thorkild I A, Strauch, Konstantin, Tiemeier, Henning, Tremoli, Elena, van der Harst, Pim, Vestergaard, Henrik, Vollenweider, Peter, Wareham, Nicholas J, Weir, David R, Whitfield, John B, Wilson, James F, Tyrrell, Jessica, Frayling, Timothy M, Barroso, Ines, Boehnke, Michael, Deloukas, Panagiotis, Fox, Caroline S, Hirschhorn, Joel N, Hunter, David J, Spector, Tim D, Strachan, David P, van Duijn, Cornelia M, Heid, Iris M, Mohlke, Karen L, Marchini, Jonathan, Loos, Ruth J F, Kilpelainen, Tuomas O, Liu, Ching-Ti, Borecki, Ingrid B, North, Kari E, and Cupples, L Adrienne
Abstract: Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
Published: 2017
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220. Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study

Author: Ding, Ming, Huang, Tao, Bergholdt, Helle K. M., Nordestgaard, Borge G., Ellervik, Christina, Qi, Lu, Frazier-Wood, Alexis C., Aslibekyan, Stella, North, Kari E., Voortman, Trudy, Graff, Mariaelisa, Smith, Caren E., Lai, Chao-Qiang, Varbo, Anette, Lemaitre, Rozenn N., de Jonge, Ester A. L., Fumeron, Frederic, Corella, Dolores, Wang, Carol A., Tjonneland, Anne, Overvad, Kim, Sorensen, Thorkild I. A., Feitosa, Mary F., Wojczynski, Mary K., Kahonen, Mika, Ahmad, Shafqat, Renström, Frida, Psaty, Bruce M., Siscovick, David S., Barroso, Ines, Johansson, Ingegerd, Hernandez, Dena, Ferrucci, Luigi, Bandinelli, Stefania, Linneberg, Allan, Sandholt, Camilla Helene, Pedersen, Oluf, Hansen, Torben, Schulz, Christina-Alexandra, Sonestedt, Emily, Orho-Melander, Marju, Chen, Tzu-An, Rotter, Jerome I., Allison, Mathew A., Rich, Stephen S., Sorli, Jose V., Coltell, Oscar, Pennell, Craig E., Eastwood, Peter R., Hofman, Albert, Uitterlinden, Andre G., Zillikens, MCarola, van Rooij, Frank J. A., Chu, Audrey Y., Rose, Lynda M., Ridker, Paul M., Viikari, Jorma, Raitakari, Olli, Lehtimaki, Terho, Mikkila, Vera, Willett, Walter C., Wang, Yujie, Tucker, Katherine L., Ordovas, Jose M., Kilpelainen, Tuomas O., Province, Michael A., Franks, Paul W., Arnett, Donna K., Tanaka, Toshiko, Toft, Ulla, Ericso, Ulrika, Franco, Oscar H., Mozaffarian, Dariush, Hu, Frank B., Chasman, Daniel I., Ding, Ming, Huang, Tao, Bergholdt, Helle K. M., Nordestgaard, Borge G., Ellervik, Christina, Qi, Lu, Frazier-Wood, Alexis C., Aslibekyan, Stella, North, Kari E., Voortman, Trudy, Graff, Mariaelisa, Smith, Caren E., Lai, Chao-Qiang, Varbo, Anette, Lemaitre, Rozenn N., de Jonge, Ester A. L., Fumeron, Frederic, Corella, Dolores, Wang, Carol A., Tjonneland, Anne, Overvad, Kim, Sorensen, Thorkild I. A., Feitosa, Mary F., Wojczynski, Mary K., Kahonen, Mika, Ahmad, Shafqat, Renström, Frida, Psaty, Bruce M., Siscovick, David S., Barroso, Ines, Johansson, Ingegerd, Hernandez, Dena, Ferrucci, Luigi, Bandinelli, Stefania, Linneberg, Allan, Sandholt, Camilla Helene, Pedersen, Oluf, Hansen, Torben, Schulz, Christina-Alexandra, Sonestedt, Emily, Orho-Melander, Marju, Chen, Tzu-An, Rotter, Jerome I., Allison, Mathew A., Rich, Stephen S., Sorli, Jose V., Coltell, Oscar, Pennell, Craig E., Eastwood, Peter R., Hofman, Albert, Uitterlinden, Andre G., Zillikens, MCarola, van Rooij, Frank J. A., Chu, Audrey Y., Rose, Lynda M., Ridker, Paul M., Viikari, Jorma, Raitakari, Olli, Lehtimaki, Terho, Mikkila, Vera, Willett, Walter C., Wang, Yujie, Tucker, Katherine L., Ordovas, Jose M., Kilpelainen, Tuomas O., Province, Michael A., Franks, Paul W., Arnett, Donna K., Tanaka, Toshiko, Toft, Ulla, Ericso, Ulrika, Franco, Oscar H., Mozaffarian, Dariush, Hu, Frank B., and Chasman, Daniel I.
Abstract: OBJECTIVE To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. DESIGN Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. SETTING CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. PARTICIPANTS Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis. MAIN OUTCOME MEASURES The instrumental variable estimation was conducted using the ratio of coefficients approach. Using metaanalysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized. RESULTS Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P<0.001) and was not associated with systolic blood pressure (0.31, 95% confidence interval -0.05 to 0.68 mm Hg; P=0.09) or risk of hypertension (odds ratio 1.01, 95% confidence interval 0.97 to 1.05; P=0.27). Using LCT-13910 rs4988235 as the instrumental variable, genetically determined dairy consumption was not associated with systolic blood pressure (beta=1.35, 95% confidence interval -0.28 to 2.97 mm Hg for each serving/day) or risk of hypertension (odds ratio 1.04, 0.88 to 1.24). Moreover, meta-analysis of the published clinical trials showed that higher dairy intake has no significant effect on change in systolic blood pressure for interventions over one month to 12 months (intervention compared with control groups: beta=-0.21, 95% confidence interval -0.98 t
Published: 2017
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221. Exome-wide association study of plasma lipids in > 300,000 individuals

Author: Liu, Dajiang J., Peloso, Gina M., Yu, Haojie, Butterworth, Adam S., Wang, Xiao, Mahajan, Anubha, Saleheen, Danish, Emdin, Connor, Alam, Dewan, Alves, Alexessander Couto, Amouyel, Philippe, Di Angelantonio, Emanuele, Arveiler, Dominique, Assimes, Themistocles L., Auer, Paul L., Baber, Usman, Ballantyne, Christie M., Bang, Lia E., Benn, Marianne, Bis, Joshua C., Boehnke, Michael, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P., Brandslund, Ivan, Brown, Morris, Busonero, Fabio, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Y. Eugene, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Connell, John M., Cucca, Francesco, Cupples, L. Adrienne, Damrauer, Scott M., Davies, Gail, Deary, Ian J., Dedoussis, George, Denny, Joshua C., Dominiczak, Anna, Dube, Marie-Pierre, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Tonu, Farmaki, Aliki-Eleni, Feitosa, Mary F., Ferrario, Marco, Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Frayling, Timothy M., Frikke-Schmidt, Ruth, Fritsche, Lars G., Frossard, Philippe, Fuster, Valentin, Ganesh, Santhi K., Gao, Wei, Garcia, Melissa E., Gieger, Christian, Giulianini, Franco, Goodarzi, Mark O., Grallert, Harald, Grarup, Niels, Groop, Leif, Grove, Megan L., Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hirschhorn, Joel N., Holmen, Oddgeir L., Huffman, Jennifer, Huo, Yong, Hveem, Kristian, Jabeen, Sehrish, Jackson, Anne U., Jakobsdottir, Johanna, Jarvelin, Marjo-Riitta, Jensen, Gorm B., Jorgensen, Marit E., Jukema, J. Wouter, Justesen, Johanne M., Kamstrup, Pia R., Kanoni, Stavroula, Karpe, Fredrik, Kee, Frank, Khera, Amit V., Klarin, Derek, Koistinen, Heikki A., Kooner, Jaspal S., Kooperberg, Charles, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo, Langenberg, Claudia, Langsted, Anne, Launer, Lenore J., Lauritzen, Torsten, Liewald, David C. M., Lin, Li An, Linneberg, Allan, Loos, Ruth J. F., Lu, Yingchang, Lu, Xiangfeng, Magi, Reedik, Malarstig, Anders, Manichaikul, Ani, Manning, Alisa K., Mantyselka, Pekka, Marouli, Eirini, Masca, Nicholas G. D., Maschio, Andrea, Meigs, James B., Melander, Olle, Metspalu, Andres, Morris, Andrew P., Morrison, Alanna C., Mulas, Antonella, Mueller-Nurasyid, Martina, Munroe, Patricia B., Neville, Matt J., Nielsen, Jonas B., Nielsen, Sune F., Nordestgaard, Borge G., Ordovas, Jose M., Mehran, Roxana, O'Donnell, Christoper J., Orho-Melander, Marju, Molony, Cliona M., Muntendam, Pieter, Padmanabhan, Sandosh, Palmer, Colin N. A., Pasko, Dorota, Patel, Aniruddh P., Pedersen, Oluf, Perola, Markus, Peters, Annette, Pisinger, Charlotta, Pistis, Giorgio, Polasek, Ozren, Poulter, Neil, Psaty, Bruce M., Rader, Daniel J., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Rich, Stephen S., Ridker, Paul M., Rioux, John D., Robertson, Neil R., Roden, Dan M., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sanna, Serena, Sattar, Naveed, Schmidt, Ellen M., Scott, Robert A., Sever, Peter, Sevilla, Raquel S., Shaffer, Christian M., Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert V., Smith, Blair H., Somayajula, Sangeetha, Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stirrups, Kathleen E., Stitziel, Nathan, Strauch, Konstantin, Stringham, Heather M., Surendran, Praveen, Tada, Hayato, Tall, Alan R., Tang, Hua, Tardif, Jean-Claude, Taylor, Kent D., Trompet, Stella, Tsao, Philip S., Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, van Zuydam, Natalie R., Varbo, Anette, Varga, Tibor V., Virtamo, Jarmo, Waldenberger, Melanie, Wang, Nan, Wareham, Nick J., Warren, Helen R., Weeke, Peter E., Weinstock, Joshua, Wessel, Jennifer, Wilson, James G., Wilson, Peter W. F., Xu, Ming, Yaghootkar, Hanieh, Young, Robin, Zeggini, Eleftheria, Zhang, He, Zheng, Neil S., Zhang, Weihua, Zhang, Yan, Zhou, Wei, Zhou, Yanhua, Zoledziewska, Magdalena, Howson, Joanna M. M., Danesh, John, McCarthy, Mark I., Cowan, Chad A., Abecasis, Goncalo, Deloukas, Panos, Musunuru, Kiran, Willer, Cristen J., Kathiresan, Sekar, Liu, Dajiang J., Peloso, Gina M., Yu, Haojie, Butterworth, Adam S., Wang, Xiao, Mahajan, Anubha, Saleheen, Danish, Emdin, Connor, Alam, Dewan, Alves, Alexessander Couto, Amouyel, Philippe, Di Angelantonio, Emanuele, Arveiler, Dominique, Assimes, Themistocles L., Auer, Paul L., Baber, Usman, Ballantyne, Christie M., Bang, Lia E., Benn, Marianne, Bis, Joshua C., Boehnke, Michael, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P., Brandslund, Ivan, Brown, Morris, Busonero, Fabio, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Y. Eugene, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Connell, John M., Cucca, Francesco, Cupples, L. Adrienne, Damrauer, Scott M., Davies, Gail, Deary, Ian J., Dedoussis, George, Denny, Joshua C., Dominiczak, Anna, Dube, Marie-Pierre, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Tonu, Farmaki, Aliki-Eleni, Feitosa, Mary F., Ferrario, Marco, Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Frayling, Timothy M., Frikke-Schmidt, Ruth, Fritsche, Lars G., Frossard, Philippe, Fuster, Valentin, Ganesh, Santhi K., Gao, Wei, Garcia, Melissa E., Gieger, Christian, Giulianini, Franco, Goodarzi, Mark O., Grallert, Harald, Grarup, Niels, Groop, Leif, Grove, Megan L., Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hirschhorn, Joel N., Holmen, Oddgeir L., Huffman, Jennifer, Huo, Yong, Hveem, Kristian, Jabeen, Sehrish, Jackson, Anne U., Jakobsdottir, Johanna, Jarvelin, Marjo-Riitta, Jensen, Gorm B., Jorgensen, Marit E., Jukema, J. Wouter, Justesen, Johanne M., Kamstrup, Pia R., Kanoni, Stavroula, Karpe, Fredrik, Kee, Frank, Khera, Amit V., Klarin, Derek, Koistinen, Heikki A., Kooner, Jaspal S., Kooperberg, Charles, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo, Langenberg, Claudia, Langsted, Anne, Launer, Lenore J., Lauritzen, Torsten, Liewald, David C. M., Lin, Li An, Linneberg, Allan, Loos, Ruth J. F., Lu, Yingchang, Lu, Xiangfeng, Magi, Reedik, Malarstig, Anders, Manichaikul, Ani, Manning, Alisa K., Mantyselka, Pekka, Marouli, Eirini, Masca, Nicholas G. D., Maschio, Andrea, Meigs, James B., Melander, Olle, Metspalu, Andres, Morris, Andrew P., Morrison, Alanna C., Mulas, Antonella, Mueller-Nurasyid, Martina, Munroe, Patricia B., Neville, Matt J., Nielsen, Jonas B., Nielsen, Sune F., Nordestgaard, Borge G., Ordovas, Jose M., Mehran, Roxana, O'Donnell, Christoper J., Orho-Melander, Marju, Molony, Cliona M., Muntendam, Pieter, Padmanabhan, Sandosh, Palmer, Colin N. A., Pasko, Dorota, Patel, Aniruddh P., Pedersen, Oluf, Perola, Markus, Peters, Annette, Pisinger, Charlotta, Pistis, Giorgio, Polasek, Ozren, Poulter, Neil, Psaty, Bruce M., Rader, Daniel J., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Rich, Stephen S., Ridker, Paul M., Rioux, John D., Robertson, Neil R., Roden, Dan M., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sanna, Serena, Sattar, Naveed, Schmidt, Ellen M., Scott, Robert A., Sever, Peter, Sevilla, Raquel S., Shaffer, Christian M., Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert V., Smith, Blair H., Somayajula, Sangeetha, Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stirrups, Kathleen E., Stitziel, Nathan, Strauch, Konstantin, Stringham, Heather M., Surendran, Praveen, Tada, Hayato, Tall, Alan R., Tang, Hua, Tardif, Jean-Claude, Taylor, Kent D., Trompet, Stella, Tsao, Philip S., Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, van Zuydam, Natalie R., Varbo, Anette, Varga, Tibor V., Virtamo, Jarmo, Waldenberger, Melanie, Wang, Nan, Wareham, Nick J., Warren, Helen R., Weeke, Peter E., Weinstock, Joshua, Wessel, Jennifer, Wilson, James G., Wilson, Peter W. F., Xu, Ming, Yaghootkar, Hanieh, Young, Robin, Zeggini, Eleftheria, Zhang, He, Zheng, Neil S., Zhang, Weihua, Zhang, Yan, Zhou, Wei, Zhou, Yanhua, Zoledziewska, Magdalena, Howson, Joanna M. M., Danesh, John, McCarthy, Mark I., Cowan, Chad A., Abecasis, Goncalo, Deloukas, Panos, Musunuru, Kiran, Willer, Cristen J., and Kathiresan, Sekar
Abstract: We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-densitylipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.
Published: 2017
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222. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

Author: Saleheen, Danish, Zhao, Wei, Young, Robin, Nelson, Christopher P., Ho, WeangKee, Ferguson, Jane F., Rasheed, Asif, Ou, Kristy, Nurnberg, Sylvia T., Bauer, Robert C., Goel, Anuj, Do, Ron, Stewart, Alexandre F. R., Hartiala, Jaana, Zhang, Weihua, Thorleifsson, Gudmar, Strawbridge, Rona J., Sinisalo, Juha, Kanoni, Stavroula, Sedaghat, Sanaz, Marouli, Eirini, Kristiansson, Kati, Zhao, Jing Hua, Scott, Robert, Gauguier, Dominique, Shah, Svati H., Smith, Albert Vernon, van Zuydam, Natalie, Cox, Amanda J., Willenborg, Christina, Kessler, Thorsten, Zeng, Lingyao, Province, Michael A., Ganna, Andrea, Lind, Lars, Pedersen, Nancy L., White, Charles C., Joensuu, Anni, Kleber, Marcus Edi, Hall, Alistair S., Maerz, Winfried, Salomaa, Veikko, O'Donnell, Christopher, Ingelsson, Erik, Feitosa, Mary F., Erdmann, Jeanette, Bowden, Donald W., Palmer, Colin N. A., Gudnason, Vilmundur, De Faire, Ulf, Zalloua, Pierre, Wareham, Nicholas, Thompson, John R., Kuulasmaa, Kari, Dedoussis, George, Perola, Markus, Dehghan, Abbas, Chambers, John C., Kooner, Jaspal, Allayee, Hooman, Deloukas, Panos, McPherson, Ruth, Stefansson, Kari, Schunkert, Heribert, Kathiresan, Sekar, Farrall, Martin, Frossard, Philippe Marcel, Rader, Daniel J., Samani, Nilesh J., Reilly, Muredach P., Saleheen, Danish, Zhao, Wei, Young, Robin, Nelson, Christopher P., Ho, WeangKee, Ferguson, Jane F., Rasheed, Asif, Ou, Kristy, Nurnberg, Sylvia T., Bauer, Robert C., Goel, Anuj, Do, Ron, Stewart, Alexandre F. R., Hartiala, Jaana, Zhang, Weihua, Thorleifsson, Gudmar, Strawbridge, Rona J., Sinisalo, Juha, Kanoni, Stavroula, Sedaghat, Sanaz, Marouli, Eirini, Kristiansson, Kati, Zhao, Jing Hua, Scott, Robert, Gauguier, Dominique, Shah, Svati H., Smith, Albert Vernon, van Zuydam, Natalie, Cox, Amanda J., Willenborg, Christina, Kessler, Thorsten, Zeng, Lingyao, Province, Michael A., Ganna, Andrea, Lind, Lars, Pedersen, Nancy L., White, Charles C., Joensuu, Anni, Kleber, Marcus Edi, Hall, Alistair S., Maerz, Winfried, Salomaa, Veikko, O'Donnell, Christopher, Ingelsson, Erik, Feitosa, Mary F., Erdmann, Jeanette, Bowden, Donald W., Palmer, Colin N. A., Gudnason, Vilmundur, De Faire, Ulf, Zalloua, Pierre, Wareham, Nicholas, Thompson, John R., Kuulasmaa, Kari, Dedoussis, George, Perola, Markus, Dehghan, Abbas, Chambers, John C., Kooner, Jaspal, Allayee, Hooman, Deloukas, Panos, McPherson, Ruth, Stefansson, Kari, Schunkert, Heribert, Kathiresan, Sekar, Farrall, Martin, Frossard, Philippe Marcel, Rader, Daniel J., Samani, Nilesh J., and Reilly, Muredach P.
Abstract: BACKGROUND: Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. METHODS: We analyzed data on 60 919 CHD cases and 80 243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to be associated with CHD risk. We also studied 5 loci associated with smoking behavior. Study-specific gene-smoking interaction effects were calculated and pooled using fixed-effects meta-analyses. Interaction analyses were declared to be significant at a P value of < 1.0x10-3 (Bonferroni correction for 50 tests). RESULTS: We identified novel gene-smoking interaction for a variant upstream of the ADAMTS7 gene. Every T allele of rs7178051 was associated with lower CHD risk by 12% in never-smokers (P= 1.3x10(-16)) in comparison with 5% in ever-smokers (P= 2.5x10-4), translating to a 60% loss of CHD protection conferred by this allelic variation in people who smoked tobacco (interaction P value= 8.7x10-5). The protective T allele at rs7178051 was also associated with reduced ADAMTS7 expression in human aortic endothelial cells and lymphoblastoid cell lines. Exposure of human coronary artery smooth muscle cells to cigarette smoke extract led to induction of ADAMTS7. CONCLUSIONS: Allelic variation at rs7178051 that associates with reduced ADAMTS7 expression confers stronger CHD protection in never-smokers than in ever-smokers. Increased vascular ADAMTS7 expression may contribute to the loss of CHD protection in smokers.
Published: 2017
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223. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author: Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y, Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zolta'n, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph C., Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F., Bonnefond, Amelie, Bragg-Gresham, Jennifer L., Cadby, Gemma, Chittani, Martina, Coggeshall, Scott, Corre, Tanguy, Direk, Nese, Eriksson, Joel, Fischer, Krista, Gorski, Mathias, Harder, Marie Neergaard, Horikoshi, Momoko, Huang, Tao, Huffman, Jennifer E., Jackson, Anne U., Justesen, Johanne Marie, Kanoni, Stavroula, Kinnunen, Leena, Kleber, Marcus E., Komulainen, Pirjo, Kumari, Meena, Lim, Unhee, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Middelberg, Rita P S, Müller-Nurasyid, Martina, Navarro, Pau, Pe'russe, Louis, Pervjakova, Natalia, Sarti, Cinzia, Smith, Albert Vernon, Smith, Jennifer A., Stanča'kova, Alena, Strawbridge, Rona J., Stringham, Heather M., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Van Der Laan, Sander W., van der Most, Peter J., Van Vliet-Ostaptchouk, Jana V., Vedantam, Sailaja L., Verweij, Niek, Vink, Jacqueline M., Vitart, Veronique, Wu, Ying, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zimmermann, Martina E., Zubair, Niha, Abecasis, Gonçalo R., Adair, Linda S., Afaq, Saima, Afzal, Uzma, Bakker, Stephan J. L., Bartz, Traci M., Beilby, John, Bergman, Richard N., Bergmann, Sven, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L., Bottinger, Erwin P., Braga, Daniele, Buckley, Brendan M., Buyske, Steve, Campbell, Harry, Chambers, John C., Collins, Francis S., Curran, Joanne E., De Borst, Gert J., De Craen, Anton J M, de Geus, Eco J. C., Dedoussis, George, Delgado, Graciela E., Den Ruijter, Hester M., Eiriksdottir, Gudny, Eriksson, Anna L., Esko, Toñu, Faul, Jessica D., Ford, Ian, Forrester, Terrence, Gertow, Karl, Gigante, Bruna, Glorioso, Nicola, Gong, Jian, Grallert, Harald, Grammer, Tanja B., Grarup, Niels, Haitjema, Saskia, Hallmans, Göran, Hamsten, Anders, Hansen, Torben, Harris, Tamara B., Hartman, Catharina A., Hassinen, Maija, Hastie, Nicholas D., Heath, Andrew C., Hernandez, Dena G., Hindorff, Lucia A., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L, Homuth, Georg, Hottenga, Jouke-Jan, Huang, Jie, Hung, Joseph, Hutri-Kähönen, Nina, Ingelsson, Erik, James, Alan L., Jansson, John Olov, Jarvelin, Marjo-Riitta, Jhun, Min A, Jorgensen, Marit E., Juonala, Markus, Kähönen, Mika, Karlsson, Magnus, Koistinen, Heikki A., Kolcic, Ivana, Kolovou, Genovefa, Kooperberg, Charles, Krämer, Bernhard K, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Leander, Karin, Lee, Nanette R., Lind, Lars, Lindgren, Cecilia M., Linneberg, Allan, Lobbens, Stephane, Loh, Marie, Lorentzon, Mattias, Luben, Robert, Lubke, Gitta, Ludolph-Donislawski, Anja, Lupoli, Sara, Madden, Pamela A. F., Männikkö, Reija, Marques-Vidal, Pedro, Martin, Nicholas G., McKenzie, Colin A., McKnight, Barbara, Mellström, Dan, Menni, Cristina, Montgomery, Grant W., Musk, Arthur W., Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M., Oldehinkel, Albertine J., Olden, Matthias, Ong, Ken K., Padmanabhan, Sandosh, Peyser, Patricia A., Pisinger, Charlotta, Porteous, David J., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rasmussen-Torvik, Laura J., Rawal, Rajesh, Rice, Treva K., Ridker, Paul M., Rose, Lynda M., Bien, Stephanie A., Rudan, Igor, Sanna, Serena, Sarzynski, Mark A., Sattar, Naveed, Savonen, Kai, Schlessinger, David, Scholtens, Salome, Schurmann, Claudia, Scott, Robert A., Sennblad, Bengt, Siemelink, Marten A., Silbernagel, Günther, Slagboom, P. Eline, Snieder, Harold, Staessen, Jan A., Stott, David J., Swertz, Morris A., Swift, Amy J., Taylor, Kent D., Tayo, Bamidele O., Thorand, Barbara, Thuillier, Dorothee, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vandenput, Liesbeth, Vohl, Marie-Claude, Völzke, Henry, Vonk, Judith M., Waeber, Ge'rard, Waldenberger, Melanie, Westendorp, Rudi G. J., Wild, Sarah H., Willemsen, Gonneke, Wolffenbuttel, Bruce H.R., Wong, Andrew, Wright, Alan F., Zhao, Wei, Zillikens, M. Carola, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Böger, Carsten A, Boomsma, Dorret I., Bouchard, Claude, Bruinenberg, Marcel, Chasman, Daniel I., Ida Chen, Yii Der, Chines, Peter S., Cooper, Richard S., Cucca, Francesco, Cusi, Daniele, de Faire, Ulf, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Gordon-Larsen, Penny, Grabe, Hans Jörgen, Gudnason, Vilmundur, Haiman, Christopher A., Hayward, Caroline, Hveem, Kristian, Johnson, Andrew D., Jukema, J. Wouter, Kardia, Sharon L. R., Kivimaki, Mika, Kooner, Jaspal S., Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Le Marchand, Loic, März, Winfried, McCarthy, Mark I., Metspalu, Andres, Morris, Andrew P., Ohlsson, Claes, Palmer, Lyle J., Pasterkamp, Gerard, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Smith, Blair H., Sorensen, Thorkild I. A., Strauch, Konstantin, Tiemeier, Henning, Tremoli, Elena, van der Harst, Pim, Vestergaard, Henrik, Vollenweider, Peter, Wareham, Nicholas J., Weir, David R., Whitfield, John B., Wilson, James F., Tyrrell, Jessica, Frayling, Timothy M., Barroso, Inês, Boehnke, Michael, Deloukas, Panagiotis, Fox, Caroline S., Hirschhorn, Joel N., Hunter, David J., Spector, Tim D., Strachan, David P., Van Duijn, Cornelia M., Heid, Iris M., Mohlke, Karen L., Marchini, Jonathan, Loos, Ruth J. F., Kilpeläinen, Tuomas O, Liu, Ching-Ti, Borecki, Ingrid B., North, Kari E., Cupples, L. Adrienne, Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y, Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zolta'n, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph C., Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F., Bonnefond, Amelie, Bragg-Gresham, Jennifer L., Cadby, Gemma, Chittani, Martina, Coggeshall, Scott, Corre, Tanguy, Direk, Nese, Eriksson, Joel, Fischer, Krista, Gorski, Mathias, Harder, Marie Neergaard, Horikoshi, Momoko, Huang, Tao, Huffman, Jennifer E., Jackson, Anne U., Justesen, Johanne Marie, Kanoni, Stavroula, Kinnunen, Leena, Kleber, Marcus E., Komulainen, Pirjo, Kumari, Meena, Lim, Unhee, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Middelberg, Rita P S, Müller-Nurasyid, Martina, Navarro, Pau, Pe'russe, Louis, Pervjakova, Natalia, Sarti, Cinzia, Smith, Albert Vernon, Smith, Jennifer A., Stanča'kova, Alena, Strawbridge, Rona J., Stringham, Heather M., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Van Der Laan, Sander W., van der Most, Peter J., Van Vliet-Ostaptchouk, Jana V., Vedantam, Sailaja L., Verweij, Niek, Vink, Jacqueline M., Vitart, Veronique, Wu, Ying, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zimmermann, Martina E., Zubair, Niha, Abecasis, Gonçalo R., Adair, Linda S., Afaq, Saima, Afzal, Uzma, Bakker, Stephan J. L., Bartz, Traci M., Beilby, John, Bergman, Richard N., Bergmann, Sven, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L., Bottinger, Erwin P., Braga, Daniele, Buckley, Brendan M., Buyske, Steve, Campbell, Harry, Chambers, John C., Collins, Francis S., Curran, Joanne E., De Borst, Gert J., De Craen, Anton J M, de Geus, Eco J. C., Dedoussis, George, Delgado, Graciela E., Den Ruijter, Hester M., Eiriksdottir, Gudny, Eriksson, Anna L., Esko, Toñu, Faul, Jessica D., Ford, Ian, Forrester, Terrence, Gertow, Karl, Gigante, Bruna, Glorioso, Nicola, Gong, Jian, Grallert, Harald, Grammer, Tanja B., Grarup, Niels, Haitjema, Saskia, Hallmans, Göran, Hamsten, Anders, Hansen, Torben, Harris, Tamara B., Hartman, Catharina A., Hassinen, Maija, Hastie, Nicholas D., Heath, Andrew C., Hernandez, Dena G., Hindorff, Lucia A., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L, Homuth, Georg, Hottenga, Jouke-Jan, Huang, Jie, Hung, Joseph, Hutri-Kähönen, Nina, Ingelsson, Erik, James, Alan L., Jansson, John Olov, Jarvelin, Marjo-Riitta, Jhun, Min A, Jorgensen, Marit E., Juonala, Markus, Kähönen, Mika, Karlsson, Magnus, Koistinen, Heikki A., Kolcic, Ivana, Kolovou, Genovefa, Kooperberg, Charles, Krämer, Bernhard K, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Leander, Karin, Lee, Nanette R., Lind, Lars, Lindgren, Cecilia M., Linneberg, Allan, Lobbens, Stephane, Loh, Marie, Lorentzon, Mattias, Luben, Robert, Lubke, Gitta, Ludolph-Donislawski, Anja, Lupoli, Sara, Madden, Pamela A. F., Männikkö, Reija, Marques-Vidal, Pedro, Martin, Nicholas G., McKenzie, Colin A., McKnight, Barbara, Mellström, Dan, Menni, Cristina, Montgomery, Grant W., Musk, Arthur W., Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M., Oldehinkel, Albertine J., Olden, Matthias, Ong, Ken K., Padmanabhan, Sandosh, Peyser, Patricia A., Pisinger, Charlotta, Porteous, David J., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rasmussen-Torvik, Laura J., Rawal, Rajesh, Rice, Treva K., Ridker, Paul M., Rose, Lynda M., Bien, Stephanie A., Rudan, Igor, Sanna, Serena, Sarzynski, Mark A., Sattar, Naveed, Savonen, Kai, Schlessinger, David, Scholtens, Salome, Schurmann, Claudia, Scott, Robert A., Sennblad, Bengt, Siemelink, Marten A., Silbernagel, Günther, Slagboom, P. Eline, Snieder, Harold, Staessen, Jan A., Stott, David J., Swertz, Morris A., Swift, Amy J., Taylor, Kent D., Tayo, Bamidele O., Thorand, Barbara, Thuillier, Dorothee, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vandenput, Liesbeth, Vohl, Marie-Claude, Völzke, Henry, Vonk, Judith M., Waeber, Ge'rard, Waldenberger, Melanie, Westendorp, Rudi G. J., Wild, Sarah H., Willemsen, Gonneke, Wolffenbuttel, Bruce H.R., Wong, Andrew, Wright, Alan F., Zhao, Wei, Zillikens, M. Carola, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Böger, Carsten A, Boomsma, Dorret I., Bouchard, Claude, Bruinenberg, Marcel, Chasman, Daniel I., Ida Chen, Yii Der, Chines, Peter S., Cooper, Richard S., Cucca, Francesco, Cusi, Daniele, de Faire, Ulf, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Gordon-Larsen, Penny, Grabe, Hans Jörgen, Gudnason, Vilmundur, Haiman, Christopher A., Hayward, Caroline, Hveem, Kristian, Johnson, Andrew D., Jukema, J. Wouter, Kardia, Sharon L. R., Kivimaki, Mika, Kooner, Jaspal S., Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Le Marchand, Loic, März, Winfried, McCarthy, Mark I., Metspalu, Andres, Morris, Andrew P., Ohlsson, Claes, Palmer, Lyle J., Pasterkamp, Gerard, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Smith, Blair H., Sorensen, Thorkild I. A., Strauch, Konstantin, Tiemeier, Henning, Tremoli, Elena, van der Harst, Pim, Vestergaard, Henrik, Vollenweider, Peter, Wareham, Nicholas J., Weir, David R., Whitfield, John B., Wilson, James F., Tyrrell, Jessica, Frayling, Timothy M., Barroso, Inês, Boehnke, Michael, Deloukas, Panagiotis, Fox, Caroline S., Hirschhorn, Joel N., Hunter, David J., Spector, Tim D., Strachan, David P., Van Duijn, Cornelia M., Heid, Iris M., Mohlke, Karen L., Marchini, Jonathan, Loos, Ruth J. F., Kilpeläinen, Tuomas O, Liu, Ching-Ti, Borecki, Ingrid B., North, Kari E., and Cupples, L. Adrienne
Published: 2017

224. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Author: Li, Man, Li, Yong, Weeks, Olivia, Mijatovic, Vladan, Teumer, Alexander, Huffman, Jennifer E., Tromp, Gerard, Fuchsberger, Christian, Gorski, Mathias, Lyytikainen, Leo-Pekka, Nutile, Teresa, Sedaghat, Sanaz, Sorice, Rossella, Tin, Adrienne, Yang, Qiong, Ahluwalia, Tarunveer S., Arking, Dan E., Bihlmeyer, Nathan A., Boeger, Carsten A., Carroll, Robert J., Chasman, Daniel I., Comelis, Marilyn C., Dehghan, Abbas, Faul, Jessica D., Feitosa, Mary F., Gambaro, Giovanni, Gasparini, Paolo, Giulianini, Franco, Heid, Iris, Huang, Jinyan, Imboden, Medea, Jackson, Anne U., Jeff, Janina, Jhun, Min A., Katz, Ronit, Kifley, Annette, Kilpelainen, Tuomas, Kumar, Ashish, Laakso, Markku, Li-Gao, Ruifang, Lohman, Kurt, Lu, Yingchang, Maegi, Reedik, Malerba, Giovanni, Mihailov, Evelin, Mohlke, Karen L., Mook-Kanamori, Dennis O., Robino, Antonietta, Ruderfer, Douglas, Salvi, Erika, Schick, Ursula M., Schulz, Christina-Alexandra, Smith, Albert V., Smith, Jennifer A., Traglia, Michela, Yerges-Armstrong, Laura M., Zhao, Wei, Goodarzi, Mark O., Kraja, Aldi T., Liu, Chunyu, Wessel, Jennifer, Boerwinkle, Eric, Borecki, Ingrid B., Bork-Jensen, Jette, Bottinger, Erwin P., Braga, Daniele, Brandslund, Ivan, Brody, Jennifer A., Campbell, Archie, Carey, David J., Christensen, Cramer, Coresh, Josef, Crook, Errol, Curhan, Gary C., Cusi, Daniele, de Boer, Ian H., de Vries, Aiko P. J., Denny, Joshua C., Devuyst, Olivier, Dreisbach, Albert W., Endlich, Karlhans, Esko, Tonu, Franco, Oscar H., Fulop, Tibor, Gerhard, Glenn S., Gluemer, Charlotte, Gottesman, Omri, Grarup, Niels, Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hocking, Lynne, Hofman, Albert, Hu, Frank B., Husemoen, Lise Lotte N., Jackson, Rebecca D., Jorgensen, Torben, Jorgensen, Marit E., Kaehoenen, Mika, Kardia, Sharon L. R., Koenig, Wolfgang, Kooperberg, Charles, Kriebel, Jennifer, Launer, Lenore J., Lauritzen, Torsten, Lehtimaki, Terho, Levy, Daniel, Linksted, Pamela, Linneberg, Allan, Liu, Yongmei, Loos, Ruth J. F., Lupo, Antonio, Meisinger, Christine, Melander, Olle, Metspalu, Andres, Mitchell, Paul, Nauck, Matthias, Nuernberg, Peter, Orho-Melander, Marju, Parsa, Afshin, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Porteous, David, Probst-Hensch, Nicole M., Psaty, Bruce M., Qi, Lu, Raitakari, Olli T., Reiner, Alex P., Rettig, Rainer, Ridker, Paul M., Rivadeneira, Fernando, Rossouw, Jacques E., Schmidt, Frank, Siscovick, David, Soranzo, Nicole, Strauch, Konstantin, Toniolo, Daniela, Turner, Stephen T., Uitterlinden, Andre G., Ulivi, Sheila, Velayutham, Dinesh, Voelker, Uwe, Volzke, Henry, Waldenberger, Melanie, Wang, Jie Jin, Weir, David R., Witte, Daniel, Kuivaniemi, Helena, Fox, Caroline S., Franceschini, Nora, Goessling, Wolfram, Koettgen, Anna, Chu, Audrey Y., Li, Man, Li, Yong, Weeks, Olivia, Mijatovic, Vladan, Teumer, Alexander, Huffman, Jennifer E., Tromp, Gerard, Fuchsberger, Christian, Gorski, Mathias, Lyytikainen, Leo-Pekka, Nutile, Teresa, Sedaghat, Sanaz, Sorice, Rossella, Tin, Adrienne, Yang, Qiong, Ahluwalia, Tarunveer S., Arking, Dan E., Bihlmeyer, Nathan A., Boeger, Carsten A., Carroll, Robert J., Chasman, Daniel I., Comelis, Marilyn C., Dehghan, Abbas, Faul, Jessica D., Feitosa, Mary F., Gambaro, Giovanni, Gasparini, Paolo, Giulianini, Franco, Heid, Iris, Huang, Jinyan, Imboden, Medea, Jackson, Anne U., Jeff, Janina, Jhun, Min A., Katz, Ronit, Kifley, Annette, Kilpelainen, Tuomas, Kumar, Ashish, Laakso, Markku, Li-Gao, Ruifang, Lohman, Kurt, Lu, Yingchang, Maegi, Reedik, Malerba, Giovanni, Mihailov, Evelin, Mohlke, Karen L., Mook-Kanamori, Dennis O., Robino, Antonietta, Ruderfer, Douglas, Salvi, Erika, Schick, Ursula M., Schulz, Christina-Alexandra, Smith, Albert V., Smith, Jennifer A., Traglia, Michela, Yerges-Armstrong, Laura M., Zhao, Wei, Goodarzi, Mark O., Kraja, Aldi T., Liu, Chunyu, Wessel, Jennifer, Boerwinkle, Eric, Borecki, Ingrid B., Bork-Jensen, Jette, Bottinger, Erwin P., Braga, Daniele, Brandslund, Ivan, Brody, Jennifer A., Campbell, Archie, Carey, David J., Christensen, Cramer, Coresh, Josef, Crook, Errol, Curhan, Gary C., Cusi, Daniele, de Boer, Ian H., de Vries, Aiko P. J., Denny, Joshua C., Devuyst, Olivier, Dreisbach, Albert W., Endlich, Karlhans, Esko, Tonu, Franco, Oscar H., Fulop, Tibor, Gerhard, Glenn S., Gluemer, Charlotte, Gottesman, Omri, Grarup, Niels, Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hocking, Lynne, Hofman, Albert, Hu, Frank B., Husemoen, Lise Lotte N., Jackson, Rebecca D., Jorgensen, Torben, Jorgensen, Marit E., Kaehoenen, Mika, Kardia, Sharon L. R., Koenig, Wolfgang, Kooperberg, Charles, Kriebel, Jennifer, Launer, Lenore J., Lauritzen, Torsten, Lehtimaki, Terho, Levy, Daniel, Linksted, Pamela, Linneberg, Allan, Liu, Yongmei, Loos, Ruth J. F., Lupo, Antonio, Meisinger, Christine, Melander, Olle, Metspalu, Andres, Mitchell, Paul, Nauck, Matthias, Nuernberg, Peter, Orho-Melander, Marju, Parsa, Afshin, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Porteous, David, Probst-Hensch, Nicole M., Psaty, Bruce M., Qi, Lu, Raitakari, Olli T., Reiner, Alex P., Rettig, Rainer, Ridker, Paul M., Rivadeneira, Fernando, Rossouw, Jacques E., Schmidt, Frank, Siscovick, David, Soranzo, Nicole, Strauch, Konstantin, Toniolo, Daniela, Turner, Stephen T., Uitterlinden, Andre G., Ulivi, Sheila, Velayutham, Dinesh, Voelker, Uwe, Volzke, Henry, Waldenberger, Melanie, Wang, Jie Jin, Weir, David R., Witte, Daniel, Kuivaniemi, Helena, Fox, Caroline S., Franceschini, Nora, Goessling, Wolfram, Koettgen, Anna, and Chu, Audrey Y.
Abstract: Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine (eGFRcrea) among participants of European ancestry from the CKDGen Consortium (n(stage1);111,666;n(stage2): 48,343). In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (PPM1J, EDEM3, ACP1, SPEG, EYA4, CYP1A1, and ATXN2L; P-stage1<3.7 x10(-7)), of which most were common and annotated as nonsynonymous variants. Gene-based analysis identified associations of functional rare variants in three genes with eGFRcrea, including a novel association with the SOS Ras/Rho guanine nucleotide exchange factor 2 gene, SOS2 (P=5.4x 10(-8) by sequence kernel association test). Experimental follow-up in zebrafish embryos revealed changes in glomerular gene expression and renal tubule morphology in the embryonic kidney of acp1- and sos2-knockdowns. These developmental abnormalities associated with altered blood clearance rate and heightened prevalence of edema. This study expands the number of loci associated with kidney function and identifies novel genes with potential roles in kidney formation.
Published: 2017

225. Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Author: Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J., Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M., Bien, Stephanie, Yengo, Loic, Teumer, Alexander, Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard, Justesen, Johanne Marie, Kleber, Marcus E., Hollensted, Mette, Lohman, Kurt, Rivera, Natalia V., Whitfield, John B., Zhao, Jing Hua, Stringham, Heather M., Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, Peyrot, Wouter J., Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J., Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M., Bien, Stephanie, Yengo, Loic, Teumer, Alexander, Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard, Justesen, Johanne Marie, Kleber, Marcus E., Hollensted, Mette, Lohman, Kurt, Rivera, Natalia V., Whitfield, John B., Zhao, Jing Hua, Stringham, Heather M., Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, and Peyrot, Wouter J.
Published: 2017
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226. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Author: Macé, Aurélien, Tuke, Marcus A, Deelen, Patrick, Kristiansson, Kati, Mattsson, Hannele, Nõukas, Margit, Sapkota, Yadav, Schick, Ursula, Porcu, Eleonora, Rüeger, Sina, McDaid, Aaron F, Porteous, David, Winkler, Thomas W, Salvi, Erika, Shrine, Nick, Liu, Xueping, Ang, Wei Q, Zhang, Weihua, Feitosa, Mary F, Venturini, Cristina, van der Most, Peter J, Rosengren, Anders, Wood, Andrew R, Beaumont, Robin N, Jones, Samuel E, Ruth, Katherine S, Yaghootkar, Hanieh, Tyrrell, Jessica, Havulinna, Aki S, Boers, Harmen, Mägi, Reedik, Kriebel, Jennifer, Müller-Nurasyid, Martina, Perola, Markus, Nieminen, Markku, Lokki, Marja-Liisa, Kähönen, Mika, Viikari, Jorma S, Geller, Frank, Lahti, Jari, Palotie, Aarno, Koponen, Päivikki, Lundqvist, Annamari, Rissanen, Harri, Bottinger, Erwin P, Afaq, Saima, Wojczynski, Mary K, Lenzini, Petra, Nolte, Ilja M, Sparsø, Thomas, Schupf, Nicole, Christensen, Kaare, Perls, Thomas T, Newman, Anne B, Werge, Thomas, Snieder, Harold, Spector, Timothy D, Chambers, John C, Koskinen, Seppo, Melbye, Mads, Raitakari, Olli T, Lehtimäki, Terho, Tobin, Martin D, Wain, Louise V, Sinisalo, Juha, Peters, Annette, Meitinger, Thomas, Martin, Nicholas G, Wray, Naomi R, Montgomery, Grant W, Medland, Sarah E, Swertz, Morris A, Vartiainen, Erkki, Borodulin, Katja, Männistö, Satu, Murray, Anna, Bochud, Murielle, Jacquemont, Sébastien, Rivadeneira, Fernando, Hansen, Thomas F, Oldehinkel, Albertine J, Mangino, Massimo, Province, Michael A, Deloukas, Panos, Kooner, Jaspal S, Freathy, Rachel M, Pennell, Craig, Feenstra, Bjarke, Strachan, David P, Lettre, Guillaume, Hirschhorn, Joel, Cusi, Daniele, Heid, Iris M, Hayward, Caroline, Männik, Katrin, Beckmann, Jacques S, Loos, Ruth J F, Nyholt, Dale R, Metspalu, Andres, Eriksson, Johan G, Weedon, Michael N, Salomaa, Veikko, Franke, Lude, Reymond, Alexandre, Frayling, Timothy M, Kutalik, Zoltán, Macé, Aurélien, Tuke, Marcus A, Deelen, Patrick, Kristiansson, Kati, Mattsson, Hannele, Nõukas, Margit, Sapkota, Yadav, Schick, Ursula, Porcu, Eleonora, Rüeger, Sina, McDaid, Aaron F, Porteous, David, Winkler, Thomas W, Salvi, Erika, Shrine, Nick, Liu, Xueping, Ang, Wei Q, Zhang, Weihua, Feitosa, Mary F, Venturini, Cristina, van der Most, Peter J, Rosengren, Anders, Wood, Andrew R, Beaumont, Robin N, Jones, Samuel E, Ruth, Katherine S, Yaghootkar, Hanieh, Tyrrell, Jessica, Havulinna, Aki S, Boers, Harmen, Mägi, Reedik, Kriebel, Jennifer, Müller-Nurasyid, Martina, Perola, Markus, Nieminen, Markku, Lokki, Marja-Liisa, Kähönen, Mika, Viikari, Jorma S, Geller, Frank, Lahti, Jari, Palotie, Aarno, Koponen, Päivikki, Lundqvist, Annamari, Rissanen, Harri, Bottinger, Erwin P, Afaq, Saima, Wojczynski, Mary K, Lenzini, Petra, Nolte, Ilja M, Sparsø, Thomas, Schupf, Nicole, Christensen, Kaare, Perls, Thomas T, Newman, Anne B, Werge, Thomas, Snieder, Harold, Spector, Timothy D, Chambers, John C, Koskinen, Seppo, Melbye, Mads, Raitakari, Olli T, Lehtimäki, Terho, Tobin, Martin D, Wain, Louise V, Sinisalo, Juha, Peters, Annette, Meitinger, Thomas, Martin, Nicholas G, Wray, Naomi R, Montgomery, Grant W, Medland, Sarah E, Swertz, Morris A, Vartiainen, Erkki, Borodulin, Katja, Männistö, Satu, Murray, Anna, Bochud, Murielle, Jacquemont, Sébastien, Rivadeneira, Fernando, Hansen, Thomas F, Oldehinkel, Albertine J, Mangino, Massimo, Province, Michael A, Deloukas, Panos, Kooner, Jaspal S, Freathy, Rachel M, Pennell, Craig, Feenstra, Bjarke, Strachan, David P, Lettre, Guillaume, Hirschhorn, Joel, Cusi, Daniele, Heid, Iris M, Hayward, Caroline, Männik, Katrin, Beckmann, Jacques S, Loos, Ruth J F, Nyholt, Dale R, Metspalu, Andres, Eriksson, Johan G, Weedon, Michael N, Salomaa, Veikko, Franke, Lude, Reymond, Alexandre, Frayling, Timothy M, and Kutalik, Zoltán
Abstract: There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to 191,161 adult samples from 26 cohorts. The study reveals five CNV associations at 1q21.1, 3q29, 7q11.23, 11p14.2, and 18q21.32 and confirms two known loci at 16p11.2 and 22q11.21, implicating at least one anthropometric trait. The discovered CNVs are recurrent and rare (0.01-0.2%), with large effects on height (>2.4 cm), weight (>5 kg), and body mass index (BMI) (>3.5 kg/m(2)). Burden analysis shows a 0.41 cm decrease in height, a 0.003 increase in waist-to-hip ratio and increase in BMI by 0.14 kg/m(2) for each Mb of total deletion burden (P = 2.5 × 10(-10), 6.0 × 10(-5), and 2.9 × 10(-3)). Our study provides evidence that the same genes (e.g., MC4R, FIBIN, and FMO5) harbor both common and rare variants affecting body size and that anthropometric traits share genetic loci with developmental and psychiatric disorders.Individual SNPs have small effects on anthropometric traits, yet the impact of CNVs has remained largely unknown. Here, Kutalik and co-workers perform a large-scale genome-wide meta-analysis of structural variation and find rare CNVs associated with height, weight and BMI with large effect sizes.
Published: 2017

227. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author: UMC Utrecht, Experimentele Afd. Cardiologie 1, Circulatory Health, In Vivo NMR ISI, Verpleegafd Vaatchirurgie D4 Oost, Onderzoek Vrouw Hart & Vaatziekten, Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y, Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zolta'n, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph C., Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F., Bonnefond, Amelie, Bragg-Gresham, Jennifer L., Cadby, Gemma, Chittani, Martina, Coggeshall, Scott, Corre, Tanguy, Direk, Nese, Eriksson, Joel, Fischer, Krista, Gorski, Mathias, Harder, Marie Neergaard, Horikoshi, Momoko, Huang, Tao, Huffman, Jennifer E., Jackson, Anne U., Justesen, Johanne Marie, Kanoni, Stavroula, Kinnunen, Leena, Kleber, Marcus E., Komulainen, Pirjo, Kumari, Meena, Lim, Unhee, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Middelberg, Rita P S, Müller-Nurasyid, Martina, Navarro, Pau, Pe'russe, Louis, Pervjakova, Natalia, Sarti, Cinzia, Smith, Albert Vernon, Smith, Jennifer A., Stanča'kova, Alena, Strawbridge, Rona J., Stringham, Heather M., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Van Der Laan, Sander W., van der Most, Peter J., Van Vliet-Ostaptchouk, Jana V., Vedantam, Sailaja L., Verweij, Niek, Vink, Jacqueline M., Vitart, Veronique, Wu, Ying, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zimmermann, Martina E., Zubair, Niha, Abecasis, Gonçalo R., Adair, Linda S., Afaq, Saima, Afzal, Uzma, Bakker, Stephan J. L., Bartz, Traci M., Beilby, John, Bergman, Richard N., Bergmann, Sven, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L., Bottinger, Erwin P., Braga, Daniele, Buckley, Brendan M., Buyske, Steve, Campbell, Harry, Chambers, John C., Collins, Francis S., Curran, Joanne E., De Borst, Gert J., De Craen, Anton J M, de Geus, Eco J. C., Dedoussis, George, Delgado, Graciela E., Den Ruijter, Hester M., Eiriksdottir, Gudny, Eriksson, Anna L., Esko, Toñu, Faul, Jessica D., Ford, Ian, Forrester, Terrence, Gertow, Karl, Gigante, Bruna, Glorioso, Nicola, Gong, Jian, Grallert, Harald, Grammer, Tanja B., Grarup, Niels, Haitjema, Saskia, Hallmans, Göran, Hamsten, Anders, Hansen, Torben, Harris, Tamara B., Hartman, Catharina A., Hassinen, Maija, Hastie, Nicholas D., Heath, Andrew C., Hernandez, Dena G., Hindorff, Lucia A., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L, Homuth, Georg, Hottenga, Jouke-Jan, Huang, Jie, Hung, Joseph, Hutri-Kähönen, Nina, Ingelsson, Erik, James, Alan L., Jansson, John Olov, Jarvelin, Marjo-Riitta, Jhun, Min A, Jorgensen, Marit E., Juonala, Markus, Kähönen, Mika, Karlsson, Magnus, Koistinen, Heikki A., Kolcic, Ivana, Kolovou, Genovefa, Kooperberg, Charles, Krämer, Bernhard K, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Leander, Karin, Lee, Nanette R., Lind, Lars, Lindgren, Cecilia M., Linneberg, Allan, Lobbens, Stephane, Loh, Marie, Lorentzon, Mattias, Luben, Robert, Lubke, Gitta, Ludolph-Donislawski, Anja, Lupoli, Sara, Madden, Pamela A. F., Männikkö, Reija, Marques-Vidal, Pedro, Martin, Nicholas G., McKenzie, Colin A., McKnight, Barbara, Mellström, Dan, Menni, Cristina, Montgomery, Grant W., Musk, Arthur W., Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M., Oldehinkel, Albertine J., Olden, Matthias, Ong, Ken K., Padmanabhan, Sandosh, Peyser, Patricia A., Pisinger, Charlotta, Porteous, David J., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rasmussen-Torvik, Laura J., Rawal, Rajesh, Rice, Treva K., Ridker, Paul M., Rose, Lynda M., Bien, Stephanie A., Rudan, Igor, Sanna, Serena, Sarzynski, Mark A., Sattar, Naveed, Savonen, Kai, Schlessinger, David, Scholtens, Salome, Schurmann, Claudia, Scott, Robert A., Sennblad, Bengt, Siemelink, Marten A., Silbernagel, Günther, Slagboom, P. Eline, Snieder, Harold, Staessen, Jan A., Stott, David J., Swertz, Morris A., Swift, Amy J., Taylor, Kent D., Tayo, Bamidele O., Thorand, Barbara, Thuillier, Dorothee, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vandenput, Liesbeth, Vohl, Marie-Claude, Völzke, Henry, Vonk, Judith M., Waeber, Ge'rard, Waldenberger, Melanie, Westendorp, Rudi G. J., Wild, Sarah H., Willemsen, Gonneke, Wolffenbuttel, Bruce H.R., Wong, Andrew, Wright, Alan F., Zhao, Wei, Zillikens, M. Carola, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Böger, Carsten A, Boomsma, Dorret I., Bouchard, Claude, Bruinenberg, Marcel, Chasman, Daniel I., Ida Chen, Yii Der, Chines, Peter S., Cooper, Richard S., Cucca, Francesco, Cusi, Daniele, de Faire, Ulf, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Gordon-Larsen, Penny, Grabe, Hans Jörgen, Gudnason, Vilmundur, Haiman, Christopher A., Hayward, Caroline, Hveem, Kristian, Johnson, Andrew D., Jukema, J. Wouter, Kardia, Sharon L. R., Kivimaki, Mika, Kooner, Jaspal S., Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Le Marchand, Loic, März, Winfried, McCarthy, Mark I., Metspalu, Andres, Morris, Andrew P., Ohlsson, Claes, Palmer, Lyle J., Pasterkamp, Gerard, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Smith, Blair H., Sorensen, Thorkild I. A., Strauch, Konstantin, Tiemeier, Henning, Tremoli, Elena, van der Harst, Pim, Vestergaard, Henrik, Vollenweider, Peter, Wareham, Nicholas J., Weir, David R., Whitfield, John B., Wilson, James F., Tyrrell, Jessica, Frayling, Timothy M., Barroso, Inês, Boehnke, Michael, Deloukas, Panagiotis, Fox, Caroline S., Hirschhorn, Joel N., Hunter, David J., Spector, Tim D., Strachan, David P., Van Duijn, Cornelia M., Heid, Iris M., Mohlke, Karen L., Marchini, Jonathan, Loos, Ruth J. F., Kilpeläinen, Tuomas O, Liu, Ching-Ti, Borecki, Ingrid B., North, Kari E., Cupples, L. Adrienne, UMC Utrecht, Experimentele Afd. Cardiologie 1, Circulatory Health, In Vivo NMR ISI, Verpleegafd Vaatchirurgie D4 Oost, Onderzoek Vrouw Hart & Vaatziekten, Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y, Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zolta'n, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph C., Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F., Bonnefond, Amelie, Bragg-Gresham, Jennifer L., Cadby, Gemma, Chittani, Martina, Coggeshall, Scott, Corre, Tanguy, Direk, Nese, Eriksson, Joel, Fischer, Krista, Gorski, Mathias, Harder, Marie Neergaard, Horikoshi, Momoko, Huang, Tao, Huffman, Jennifer E., Jackson, Anne U., Justesen, Johanne Marie, Kanoni, Stavroula, Kinnunen, Leena, Kleber, Marcus E., Komulainen, Pirjo, Kumari, Meena, Lim, Unhee, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Middelberg, Rita P S, Müller-Nurasyid, Martina, Navarro, Pau, Pe'russe, Louis, Pervjakova, Natalia, Sarti, Cinzia, Smith, Albert Vernon, Smith, Jennifer A., Stanča'kova, Alena, Strawbridge, Rona J., Stringham, Heather M., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Van Der Laan, Sander W., van der Most, Peter J., Van Vliet-Ostaptchouk, Jana V., Vedantam, Sailaja L., Verweij, Niek, Vink, Jacqueline M., Vitart, Veronique, Wu, Ying, Yengo, Loic, Zhang, Weihua, Zhao, Jing Hua, Zimmermann, Martina E., Zubair, Niha, Abecasis, Gonçalo R., Adair, Linda S., Afaq, Saima, Afzal, Uzma, Bakker, Stephan J. L., Bartz, Traci M., Beilby, John, Bergman, Richard N., Bergmann, Sven, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L., Bottinger, Erwin P., Braga, Daniele, Buckley, Brendan M., Buyske, Steve, Campbell, Harry, Chambers, John C., Collins, Francis S., Curran, Joanne E., De Borst, Gert J., De Craen, Anton J M, de Geus, Eco J. C., Dedoussis, George, Delgado, Graciela E., Den Ruijter, Hester M., Eiriksdottir, Gudny, Eriksson, Anna L., Esko, Toñu, Faul, Jessica D., Ford, Ian, Forrester, Terrence, Gertow, Karl, Gigante, Bruna, Glorioso, Nicola, Gong, Jian, Grallert, Harald, Grammer, Tanja B., Grarup, Niels, Haitjema, Saskia, Hallmans, Göran, Hamsten, Anders, Hansen, Torben, Harris, Tamara B., Hartman, Catharina A., Hassinen, Maija, Hastie, Nicholas D., Heath, Andrew C., Hernandez, Dena G., Hindorff, Lucia A., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L, Homuth, Georg, Hottenga, Jouke-Jan, Huang, Jie, Hung, Joseph, Hutri-Kähönen, Nina, Ingelsson, Erik, James, Alan L., Jansson, John Olov, Jarvelin, Marjo-Riitta, Jhun, Min A, Jorgensen, Marit E., Juonala, Markus, Kähönen, Mika, Karlsson, Magnus, Koistinen, Heikki A., Kolcic, Ivana, Kolovou, Genovefa, Kooperberg, Charles, Krämer, Bernhard K, Kuusisto, Johanna, Kvaloy, Kirsti, Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Leander, Karin, Lee, Nanette R., Lind, Lars, Lindgren, Cecilia M., Linneberg, Allan, Lobbens, Stephane, Loh, Marie, Lorentzon, Mattias, Luben, Robert, Lubke, Gitta, Ludolph-Donislawski, Anja, Lupoli, Sara, Madden, Pamela A. F., Männikkö, Reija, Marques-Vidal, Pedro, Martin, Nicholas G., McKenzie, Colin A., McKnight, Barbara, Mellström, Dan, Menni, Cristina, Montgomery, Grant W., Musk, Arthur W., Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M., Oldehinkel, Albertine J., Olden, Matthias, Ong, Ken K., Padmanabhan, Sandosh, Peyser, Patricia A., Pisinger, Charlotta, Porteous, David J., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rasmussen-Torvik, Laura J., Rawal, Rajesh, Rice, Treva K., Ridker, Paul M., Rose, Lynda M., Bien, Stephanie A., Rudan, Igor, Sanna, Serena, Sarzynski, Mark A., Sattar, Naveed, Savonen, Kai, Schlessinger, David, Scholtens, Salome, Schurmann, Claudia, Scott, Robert A., Sennblad, Bengt, Siemelink, Marten A., Silbernagel, Günther, Slagboom, P. Eline, Snieder, Harold, Staessen, Jan A., Stott, David J., Swertz, Morris A., Swift, Amy J., Taylor, Kent D., Tayo, Bamidele O., Thorand, Barbara, Thuillier, Dorothee, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vandenput, Liesbeth, Vohl, Marie-Claude, Völzke, Henry, Vonk, Judith M., Waeber, Ge'rard, Waldenberger, Melanie, Westendorp, Rudi G. J., Wild, Sarah H., Willemsen, Gonneke, Wolffenbuttel, Bruce H.R., Wong, Andrew, Wright, Alan F., Zhao, Wei, Zillikens, M. Carola, Baldassarre, Damiano, Balkau, Beverley, Bandinelli, Stefania, Böger, Carsten A, Boomsma, Dorret I., Bouchard, Claude, Bruinenberg, Marcel, Chasman, Daniel I., Ida Chen, Yii Der, Chines, Peter S., Cooper, Richard S., Cucca, Francesco, Cusi, Daniele, de Faire, Ulf, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Gordon-Larsen, Penny, Grabe, Hans Jörgen, Gudnason, Vilmundur, Haiman, Christopher A., Hayward, Caroline, Hveem, Kristian, Johnson, Andrew D., Jukema, J. Wouter, Kardia, Sharon L. R., Kivimaki, Mika, Kooner, Jaspal S., Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Le Marchand, Loic, März, Winfried, McCarthy, Mark I., Metspalu, Andres, Morris, Andrew P., Ohlsson, Claes, Palmer, Lyle J., Pasterkamp, Gerard, Pedersen, Oluf, Peters, Annette, Peters, Ulrike, Polasek, Ozren, Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Smith, Blair H., Sorensen, Thorkild I. A., Strauch, Konstantin, Tiemeier, Henning, Tremoli, Elena, van der Harst, Pim, Vestergaard, Henrik, Vollenweider, Peter, Wareham, Nicholas J., Weir, David R., Whitfield, John B., Wilson, James F., Tyrrell, Jessica, Frayling, Timothy M., Barroso, Inês, Boehnke, Michael, Deloukas, Panagiotis, Fox, Caroline S., Hirschhorn, Joel N., Hunter, David J., Spector, Tim D., Strachan, David P., Van Duijn, Cornelia M., Heid, Iris M., Mohlke, Karen L., Marchini, Jonathan, Loos, Ruth J. F., Kilpeläinen, Tuomas O, Liu, Ching-Ti, Borecki, Ingrid B., North, Kari E., and Cupples, L. Adrienne
Published: 2017

228. Exome-wide association study of plasma lipids in >300,000 individuals

Author: Liu, Dajiang J., Peloso, Gina M., Yu, Haojie, Butterworth, Adam S., Wang, Xiao, Mahajan, Anubha, Saleheen, Danish, Emdin, Connor, Alam, Dewan, Alves, Alexessander Couto, Amouyel, Philippe, Angelantonio, Emanuele DI, Arveiler, Dominique, Assimes, Themistocles L., Auer, Paul L., Baber, Usman, Ballantyne, Christie M., Bang, Lia E., Benn, Marianne, Bis, Joshua C., Boehnke, Michael, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P., Brandslund, Ivan, Brown, Morris, Busonero, Fabio, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Y. Eugene, Chen, Yii Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Connell, John M., Cucca, Francesco, Cupples, L. Adrienne, Damrauer, Scott M., Davies, Gail, Deary, Ian J., Dedoussis, George, Denny, Joshua C., Dominiczak, Anna, Dubé, Marie Pierre, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Toñu, Farmaki, Aliki Eleni, Feitosa, Mary F., Ferrario, Marco, Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Frayling, Timothy M., Frikke-Schmidt, Ruth, Fritsche, Lars G., Frossard, Philippe, Fuster, Valentin, Ganesh, Santhi K., Gao, Wei, Garcia, Melissa E., Gieger, Christian, Giulianini, Franco, Goodarzi, Mark O., Grallert, Harald, Grarup, Niels, Groop, Leif, Grove, Megan L., Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hirschhorn, Joel N., Holmen, Oddgeir L., Huffman, Jennifer, Huo, Yong, Hveem, Kristian, Jabeen, Sehrish, Jackson, Anne U., Jakobsdottir, Johanna, Jarvelin, Marjo Riitta, Jensen, Gorm B., Jørgensen, Marit E., Jukema, J. Wouter, Justesen, Johanne M., Kamstrup, Pia R., Kanoni, Stavroula, Karpe, Fredrik, Kee, Frank, Khera, Amit V., Klarin, Derek, Koistinen, Heikki A., Kooner, Jaspal S., Kooperberg, Charles, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo, Langenberg, Claudia, Langsted, Anne, Launer, Lenore J., Lauritzen, Torsten, MLiewald, David C., Lin, Li An, Linneberg, Allan, Loos, Ruth J.F., Lu, Yingchang, Lu, Xiangfeng, Mägi, Reedik, Malarstig, Anders, Manichaikul, Ani, Manning, Alisa K., Mäntyselkä, Pekka, Marouli, Eirini, Masca, Nicholas G.D., Maschio, Andrea, Meigs, James B., Melander, Olle, Metspalu, Andres, Morris, Andrew P., Morrison, Alanna C., Mulas, Antonella, Müller-Nurasyid, Martina, Munroe, Patricia B., Neville, Matt J., Nielsen, Sune F., Nielsen, Jonas B., Nordestgaard, Børge G., Ordovas, Jose M., Mehran, Roxana, O'Donnell, Christoper J., Orho-Melander, Marju, Molony, Cliona M., Muntendam, Pieter, Padmanabhan, Sandosh, Palmer, Colin N.A., Pasko, Dorota, Patel, Aniruddh P., Pedersen, Oluf, Perola, Markus, Peters, Annette, Pisinger, Charlotta, Pistis, Giorgio, Polasek, Ozren, Poulter, Neil, Psaty, Bruce M., Rader, Daniel J., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Rich, Stephen S., Ridker, Paul M., Rioux, John D., Robertson, Neil R., Roden, Dan M., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sanna, Serena, Sattar, Naveed, Schmidt, Ellen M., Scott, Robert A., Sever, Peter, Sevilla, Raquel S., Shaffer, Christian M., Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert V., Smith, Blair H., Somayajula, Sangeetha, Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stirrups, Kathleen E., Stitziel, Nathan, Strauch, Konstantin, Stringham, Heather M., Surendran, Praveen, Tada, Hayato, Tall, Alan R., Tang, Hua, Tardif, Jean Claude, Taylor, Kent D., Trompet, Stella, Tsao, Philip S., Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Zuydam, Natalie R.Van, Varbo, Anette, Varga, Tibor V., Virtamo, Jarmo, Waldenberger, Melanie, Wang, Nan, Wareham, Nick J., Warren, Helen R., Weeke, Peter E., Weinstock, Joshua, Wessel, Jennifer, Wilson, James G., Wilson, Peter W.F., Xu, Ming, Yaghootkar, Hanieh, Young, Robin, Zeggini, Eleftheria, Zhang, He, Zheng, Neil S., Zhang, Weihua, Zhang, Yan, Zhou, Wei, Zhou, Yanhua, Zoledziewska, Magdalena, Howson, Joanna M.M., Danesh, John, McCarthy, Mark I., Cowan, Chad A., Abecasis, Goncalo, Deloukas, Panos, Musunuru, Kiran, Willer, Cristen J., Kathiresan, Sekar, V Varga, Tibor, Liu, Dajiang J., Peloso, Gina M., Yu, Haojie, Butterworth, Adam S., Wang, Xiao, Mahajan, Anubha, Saleheen, Danish, Emdin, Connor, Alam, Dewan, Alves, Alexessander Couto, Amouyel, Philippe, Angelantonio, Emanuele DI, Arveiler, Dominique, Assimes, Themistocles L., Auer, Paul L., Baber, Usman, Ballantyne, Christie M., Bang, Lia E., Benn, Marianne, Bis, Joshua C., Boehnke, Michael, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P., Brandslund, Ivan, Brown, Morris, Busonero, Fabio, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Y. Eugene, Chen, Yii Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Connell, John M., Cucca, Francesco, Cupples, L. Adrienne, Damrauer, Scott M., Davies, Gail, Deary, Ian J., Dedoussis, George, Denny, Joshua C., Dominiczak, Anna, Dubé, Marie Pierre, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Toñu, Farmaki, Aliki Eleni, Feitosa, Mary F., Ferrario, Marco, Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Frayling, Timothy M., Frikke-Schmidt, Ruth, Fritsche, Lars G., Frossard, Philippe, Fuster, Valentin, Ganesh, Santhi K., Gao, Wei, Garcia, Melissa E., Gieger, Christian, Giulianini, Franco, Goodarzi, Mark O., Grallert, Harald, Grarup, Niels, Groop, Leif, Grove, Megan L., Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hirschhorn, Joel N., Holmen, Oddgeir L., Huffman, Jennifer, Huo, Yong, Hveem, Kristian, Jabeen, Sehrish, Jackson, Anne U., Jakobsdottir, Johanna, Jarvelin, Marjo Riitta, Jensen, Gorm B., Jørgensen, Marit E., Jukema, J. Wouter, Justesen, Johanne M., Kamstrup, Pia R., Kanoni, Stavroula, Karpe, Fredrik, Kee, Frank, Khera, Amit V., Klarin, Derek, Koistinen, Heikki A., Kooner, Jaspal S., Kooperberg, Charles, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo, Langenberg, Claudia, Langsted, Anne, Launer, Lenore J., Lauritzen, Torsten, MLiewald, David C., Lin, Li An, Linneberg, Allan, Loos, Ruth J.F., Lu, Yingchang, Lu, Xiangfeng, Mägi, Reedik, Malarstig, Anders, Manichaikul, Ani, Manning, Alisa K., Mäntyselkä, Pekka, Marouli, Eirini, Masca, Nicholas G.D., Maschio, Andrea, Meigs, James B., Melander, Olle, Metspalu, Andres, Morris, Andrew P., Morrison, Alanna C., Mulas, Antonella, Müller-Nurasyid, Martina, Munroe, Patricia B., Neville, Matt J., Nielsen, Sune F., Nielsen, Jonas B., Nordestgaard, Børge G., Ordovas, Jose M., Mehran, Roxana, O'Donnell, Christoper J., Orho-Melander, Marju, Molony, Cliona M., Muntendam, Pieter, Padmanabhan, Sandosh, Palmer, Colin N.A., Pasko, Dorota, Patel, Aniruddh P., Pedersen, Oluf, Perola, Markus, Peters, Annette, Pisinger, Charlotta, Pistis, Giorgio, Polasek, Ozren, Poulter, Neil, Psaty, Bruce M., Rader, Daniel J., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Rich, Stephen S., Ridker, Paul M., Rioux, John D., Robertson, Neil R., Roden, Dan M., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sanna, Serena, Sattar, Naveed, Schmidt, Ellen M., Scott, Robert A., Sever, Peter, Sevilla, Raquel S., Shaffer, Christian M., Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert V., Smith, Blair H., Somayajula, Sangeetha, Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stirrups, Kathleen E., Stitziel, Nathan, Strauch, Konstantin, Stringham, Heather M., Surendran, Praveen, Tada, Hayato, Tall, Alan R., Tang, Hua, Tardif, Jean Claude, Taylor, Kent D., Trompet, Stella, Tsao, Philip S., Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Zuydam, Natalie R.Van, Varbo, Anette, Varga, Tibor V., Virtamo, Jarmo, Waldenberger, Melanie, Wang, Nan, Wareham, Nick J., Warren, Helen R., Weeke, Peter E., Weinstock, Joshua, Wessel, Jennifer, Wilson, James G., Wilson, Peter W.F., Xu, Ming, Yaghootkar, Hanieh, Young, Robin, Zeggini, Eleftheria, Zhang, He, Zheng, Neil S., Zhang, Weihua, Zhang, Yan, Zhou, Wei, Zhou, Yanhua, Zoledziewska, Magdalena, Howson, Joanna M.M., Danesh, John, McCarthy, Mark I., Cowan, Chad A., Abecasis, Goncalo, Deloukas, Panos, Musunuru, Kiran, Willer, Cristen J., Kathiresan, Sekar, and V Varga, Tibor
Abstract: We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-densitylipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TGrich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.
Published: 2017

229. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author: Zillikens, M.C., Demissie, Serkalem, Hsu, Yi Hsiang, Yerges-Armstrong, Laura M., Chou, Wen Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, J.A., Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A.M., DIatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay Tee, Kilpelaïnen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S.L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia M., Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O'Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephan, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Raïkkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M.A., Tan, Sian Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichman, H.E., Widen, Elisabeth, Williams, Frances M.K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, Van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn M., Loos, Ruth J.F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P., Zillikens, M.C., Demissie, Serkalem, Hsu, Yi Hsiang, Yerges-Armstrong, Laura M., Chou, Wen Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, J.A., Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A.M., DIatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay Tee, Kilpelaïnen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S.L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia M., Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O'Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephan, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Raïkkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M.A., Tan, Sian Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichman, H.E., Widen, Elisabeth, Williams, Frances M.K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, Van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn M., Loos, Ruth J.F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, and Kiel, Douglas P.
Abstract: Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10-8) or suggestively genome wide (p < 2.3 × 10-6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.
Published: 2017

230. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author: Zillikens, M.C., Demissie, Serkalem, Hsu, Yi Hsiang, Yerges-Armstrong, Laura M., Chou, Wen Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, J., Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A.M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S.L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O'Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C.J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M.A., Tan, Sian Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.E., Widen, Elisabeth, Williams, Frances M.K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J.F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P., Zillikens, M.C., Demissie, Serkalem, Hsu, Yi Hsiang, Yerges-Armstrong, Laura M., Chou, Wen Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, J., Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A.M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S.L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O'Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C.J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M.A., Tan, Sian Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.E., Widen, Elisabeth, Williams, Frances M.K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J.F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, and Kiel, Douglas P.
Abstract: A correction to this article has been published and is linked from the HTML version of this article.
Published: 2017

231. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

Author: Chasman, Daniel I., Fuchsberger, Christian, Pattaro, Cristian, Teumer, Alexander, Böger, Carsten A., Endlich, Karlhans, Olden, Matthias, Chen, Ming-Huei, Tin, Adrienne, Taliun, Daniel, Li, Man, Gao, Xiaoyi, Gorski, Mathias, Yang, Qiong, Hundertmark, Claudia, Foster, Meredith C., O'Seaghdha, Conall M., Glazer, Nicole, Isaacs, Aaron, Liu, Ching-Ti, Smith, Albert V., O'Connell, Jeffrey R., Struchalin, Maksim, Tanaka, Toshiko, Li, Guo, Johnson, Andrew D., Gierman, Hinco J., Feitosa, Mary F., Hwang, Shih-Jen, Atkinson, Elizabeth J., Lohman, Kurt, Cornelis, Marilyn C., Johansson, Åsa, Tönjes, Anke, Dehghan, Abbas, Lambert, Jean-Charles, Holliday, Elizabeth G., Sorice, Rossella, Kutalik, Zoltan, Lehtimäki, Terho, Esko, Tõnu, Deshmukh, Harshal, Ulivi, Sheila, Chu, Audrey Y., Murgia, Federico, Trompet, Stella, Imboden, Medea, Coassin, Stefan, Pistis, Giorgio, Harris, Tamara B., Launer, Lenore J., Aspelund, Thor, Eiriksdottir, Gudny, Mitchell, Braxton D., Boerwinkle, Eric, Schmidt, Helena, Cavalieri, Margherita, Rao, Madhumathi, Hu, Frank, Demirkan, Ayse, Oostra, Ben A., de Andrade, Mariza, Turner, Stephen T., Ding, Jingzhong, Andrews, Jeanette S., Freedman, Barry I., Giulianini, Franco, Koenig, Wolfgang, Illig, Thomas, Meisinger, Christa, Gieger, Christian, Zgaga, Lina, Zemunik, Tatijana, Boban, Mladen, Minelli, Cosetta, Wheeler, Heather E., Igl, Wilmar, Zaboli, Ghazal, Wild, Sarah H., Wright, Alan F., Campbell, Harry, Ellinghaus, David, Nöthlings, Ute, Jacobs, Gunnar, Biffar, Reiner, Ernst, Florian, Homuth, Georg, Kroemer, Heyo K., Nauck, Matthias, Stracke, Sylvia, Völker, Uwe, Völzke, Henry, Kovacs, Peter, Stumvoll, Michael, Mägi, Reedik, Hofman, Albert, Uitterlinden, Andre G., Rivadeneira, Fernando, Aulchenko, Yurii S., Polasek, Ozren, Hastie, Nick, Vitart, Veronique, Helmer, Catherine, Wang, Jie Jin, Stengel, Bénédicte, Ruggiero, Daniela, Bergmann, Sven, Kähönen, Mika, Viikari, Jorma, Nikopensius, Tiit, Province, Michael, Ketkar, Shamika, Colhoun, Helen, Doney, Alex, Robino, Antonietta, Krämer, Bernhard K., Portas, Laura, Ford, Ian, Buckley, Brendan M., Adam, Martin, Thun, Gian-Andri, Paulweber, Bernhard, Haun, Margot, Sala, Cinzia, Mitchell, Paul, Ciullo, Marina, Kim, Stuart K., Vollenweider, Peter, Raitakari, Olli, Metspalu, Andres, Palmer, Colin, Gasparini, Paolo, Pirastu, Mario, Jukema, J. Wouter, Probst-Hensch, Nicole M., Kronenberg, Florian, Toniolo, Daniela, Gudnason, Vilmundur, Shuldiner, Alan R., Coresh, Josef, Schmidt, Reinhold, Ferrucci, Luigi, Siscovick, David S., van Duijn, Cornelia M., Borecki, Ingrid B., Kardia, Sharon L.R., Liu, Yongmei, Curhan, Gary C., Rudan, Igor, Gyllensten, Ulf, Wilson, James F., Franke, Andre, Pramstaller, Peter P., Rettig, Rainer, Prokopenko, Inga, Witteman, Jacqueline, Hayward, Caroline, Ridker, Paul M., Parsa, Afshin, Bochud, Murielle, Heid, Iris M., Kao, W.H. Linda, Fox, Caroline S., Köttgen, Anna, Chasman, Daniel I., Fuchsberger, Christian, Pattaro, Cristian, Teumer, Alexander, Böger, Carsten A., Endlich, Karlhans, Olden, Matthias, Chen, Ming-Huei, Tin, Adrienne, Taliun, Daniel, Li, Man, Gao, Xiaoyi, Gorski, Mathias, Yang, Qiong, Hundertmark, Claudia, Foster, Meredith C., O'Seaghdha, Conall M., Glazer, Nicole, Isaacs, Aaron, Liu, Ching-Ti, Smith, Albert V., O'Connell, Jeffrey R., Struchalin, Maksim, Tanaka, Toshiko, Li, Guo, Johnson, Andrew D., Gierman, Hinco J., Feitosa, Mary F., Hwang, Shih-Jen, Atkinson, Elizabeth J., Lohman, Kurt, Cornelis, Marilyn C., Johansson, Åsa, Tönjes, Anke, Dehghan, Abbas, Lambert, Jean-Charles, Holliday, Elizabeth G., Sorice, Rossella, Kutalik, Zoltan, Lehtimäki, Terho, Esko, Tõnu, Deshmukh, Harshal, Ulivi, Sheila, Chu, Audrey Y., Murgia, Federico, Trompet, Stella, Imboden, Medea, Coassin, Stefan, Pistis, Giorgio, Harris, Tamara B., Launer, Lenore J., Aspelund, Thor, Eiriksdottir, Gudny, Mitchell, Braxton D., Boerwinkle, Eric, Schmidt, Helena, Cavalieri, Margherita, Rao, Madhumathi, Hu, Frank, Demirkan, Ayse, Oostra, Ben A., de Andrade, Mariza, Turner, Stephen T., Ding, Jingzhong, Andrews, Jeanette S., Freedman, Barry I., Giulianini, Franco, Koenig, Wolfgang, Illig, Thomas, Meisinger, Christa, Gieger, Christian, Zgaga, Lina, Zemunik, Tatijana, Boban, Mladen, Minelli, Cosetta, Wheeler, Heather E., Igl, Wilmar, Zaboli, Ghazal, Wild, Sarah H., Wright, Alan F., Campbell, Harry, Ellinghaus, David, Nöthlings, Ute, Jacobs, Gunnar, Biffar, Reiner, Ernst, Florian, Homuth, Georg, Kroemer, Heyo K., Nauck, Matthias, Stracke, Sylvia, Völker, Uwe, Völzke, Henry, Kovacs, Peter, Stumvoll, Michael, Mägi, Reedik, Hofman, Albert, Uitterlinden, Andre G., Rivadeneira, Fernando, Aulchenko, Yurii S., Polasek, Ozren, Hastie, Nick, Vitart, Veronique, Helmer, Catherine, Wang, Jie Jin, Stengel, Bénédicte, Ruggiero, Daniela, Bergmann, Sven, Kähönen, Mika, Viikari, Jorma, Nikopensius, Tiit, Province, Michael, Ketkar, Shamika, Colhoun, Helen, Doney, Alex, Robino, Antonietta, Krämer, Bernhard K., Portas, Laura, Ford, Ian, Buckley, Brendan M., Adam, Martin, Thun, Gian-Andri, Paulweber, Bernhard, Haun, Margot, Sala, Cinzia, Mitchell, Paul, Ciullo, Marina, Kim, Stuart K., Vollenweider, Peter, Raitakari, Olli, Metspalu, Andres, Palmer, Colin, Gasparini, Paolo, Pirastu, Mario, Jukema, J. Wouter, Probst-Hensch, Nicole M., Kronenberg, Florian, Toniolo, Daniela, Gudnason, Vilmundur, Shuldiner, Alan R., Coresh, Josef, Schmidt, Reinhold, Ferrucci, Luigi, Siscovick, David S., van Duijn, Cornelia M., Borecki, Ingrid B., Kardia, Sharon L.R., Liu, Yongmei, Curhan, Gary C., Rudan, Igor, Gyllensten, Ulf, Wilson, James F., Franke, Andre, Pramstaller, Peter P., Rettig, Rainer, Prokopenko, Inga, Witteman, Jacqueline, Hayward, Caroline, Ridker, Paul M., Parsa, Afshin, Bochud, Murielle, Heid, Iris M., Kao, W.H. Linda, Fox, Caroline S., and Köttgen, Anna
Abstract: In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in FBXL20 (P = 5.6 × 10−9) in meta-analysis of all available data, and additional SNPs at the INHBC, LRP2, PLEKHA1, SLC3A2 and SLC7A6 genes meeting multiple-testing corrected significance for replication and overall P-values of 4.5 × 10−4-2.2 × 10−7. Neither the novel PLEKHA1 nor FBXL20 associations, both further supported by association with eGFR among African Americans and with transcript abundance, would have been implicated by eGFR candidate gene approaches. LRP2, encoding the megalin receptor, was identified through connection with the previously known eGFR gene DAB2 and extends understanding of the megalin system in kidney function. These findings highlight integration of existing genome-wide association data with independent biological knowledge to uncover novel candidate eGFR associations, including candidates lacking known connections to kidney-specific pathways. The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general
Published: 2017

232. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Author: Ried, Janina S, Jeff, Janina M, Chu, Audrey Y, Bragg-Gresham, Jennifer L, van Dongen, Jenny, Huffman, Jennifer E, Ahluwalia, Tarunveer S, Cadby, Gemma, Eklund, Niina, Eriksson, Joel, Esko, Tõnu, Feitosa, Mary F, Goel, Anuj, Gorski, Mathias, Hayward, Caroline, Heard-Costa, Nancy L, Jackson, Anne U, Jokinen, Eero, Kanoni, Stavroula, Kristiansson, Kati, Kutalik, Zoltán, Lahti, Jari, Luan, Jian'an, Mägi, Reedik, Mahajan, Anubha, Mangino, Massimo, Medina-Gomez, Carolina, Monda, Keri L, Nolte, Ilja M, Pérusse, Louis, et al, and University of Zurich
Subjects: 1300 General Biochemistry, Genetics and Molecular Biology, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 1600 General Chemistry, 3100 General Physics and Astronomy
Published: 2016
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233. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Author: Winkler, Thomas W, Justice, Anne E, Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F, Chu, Su, Czajkowski, Jacek, Esko, Tõnu, Fall, Tove, Kilpeläinen, Tuomas O, Lu, Yingchang, Mägi, Reedik, Mihailov, Evelin, Pers, Tune H, Rüeger, Sina, Teumer, Alexander, Ehret, Georg B, Ferreira, Teresa, Heard-Costa, Nancy L, Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D, Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M, Jansen, Rick, Westra, Harm-Jan, White, Charles C, Absher, Devin, Ahluwalia, Tarunveer S, Ahmad, Shafqat, Albrecht, Eva, Alves, Alexessander Couto, Bragg-Gresham, Jennifer L, de Craen, Anton J M, Bis, Joshua C, Bonnefond, Amélie, Boucher, Gabrielle, Cadby, Gemma, Cheng, Yu-Ching, Chiang, Charleston W K, Haitjema, Saskia, van der Laan, Sander W, van Setten, Jessica, Asselbergs, Folkert W, de Bakker, Paul I W, Moll, Frans L, Pasterkamp, Gerard, and den Ruijter, Hester M
Subjects: Published Erratum
Abstract: [This corrects the article DOI: 10.1371/journal.pgen.1005378.].
Published: 2016

234. Multiethnic Exome-Wide Association Study of Subclinical AtherosclerosisCLINICAL PERSPECTIVE

Author: Boerwinkle, Eric, Vojinovic, Dina, Becker, Diane M., Van Setten, Jessica, Heckbert, Susan R., Bowden, Donald W., Oudkerk, Matthijs, Heiss, Gerardo, Yao, Jie, Deary, Ian J., Goodarzi, Mark O., Bis, Joshua C., Rotter, Jerome I., Fuster, Valentin, Išgum, Ivana, Guo, Xiuqing, Taylor, Kent D., Lyytikäinen, Leo-Pekka, Li-Gao, Ruifang, Rivadeneira, Fernando, Kavousi, Maryam, Sartori, Samantha, Dörr, Marcus, Smith, Albert V., Psaty, Bruce M., Kathiresan, Sekar, Völzke, Henry, Kral, Brian G., O'Donnell, Christopher J., Baber, Usman, Newman, Anne B., Rader, Daniel J., Peyser, Patricia A., Mehran, Roxana, Nguyen, Khanh-Dung, Tada, Hayato, Trompet, Stella, De Mutsert, Renée, Feitosa, Mary F., De Jong, Pim A., Natarajan, Pradeep, Mitchell, Braxton D., Yanek, Lisa R., Massaro, Joe, Vaidya, Dhananjay, Peloso, Gina M., Turner, Stephen T., Franco, Oscar H., Bielak, Lawrence F., Borecki, Ingrid B., Harris, Tamara B., Hoffmann, Udo, Raitakari, Olli T., Marioni, Riccardo E., Jukema, J. Wouter, Gudnason, Vilmundur, Mook-Kanamori, Dennis O., Teumer, Alexander, Cupples, L. Adrienne, Kardia, Sharon L.R., Amin, Najaf, Post, Wendy, Hwang, Shih-Jen, Chen, Yii-Der Ida, Pankow, James S., Mathias, Rasika, Rosendaal, Frits, Stitziel, Nathan O., North, Kari E., Wassel, Christina L., Wardlaw, Joanna M., Lehtimäki, Terho, Van Duijn, Cornelia M., Jhun, Min A, Yerges-Armstrong, Laura M., Isaacs, Aaron, Reilly, Dermot F., De Koning, Harry, Franceschini, Nora, Van Der Lugt, Aad, Becker, Lewis C., Felix, Stephan B., Raffield, Laura M., Dehghan, Abbas, Wojczynski, Mary K., Weiss, Stefan, Wilson, James G., Kähönen, Mika, Launer, Lenore J., Mosley, Thomas H., Demirkan, Ayse, O'Connell, Jeffrey R., De Vos, Bob D., Schminke, Ulf, Province, Michael A., Völker, Uwe, Carr, J. Jeffrey, Uitterlinden, Andre G., Cox, Amanda J., and Hofman, Albert
Subjects: cardiovascular diseases
Abstract: The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease (CHD). We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent CHD.
Published: 2016
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235. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Author: Kilpelainen, Tuomas O., Martin-Carli, Jayne Frances, Skowronski, Alicja Anna, Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F., Hedman, Asa K., Drong, Alexander W., Hayes, James E., Zhao, Jinghua, Pers, Tune H., Schick, Ursula, Grarup, Niels, Kutalik, Zolt��n, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytik��inen, Leo-Pekka, Eriksson, Joel, Henneman, Peter, Lahti, Jari, Tanaka, Toshiko, Luan, Jian��an, Del Greco M, Fabiola, Pasko, Dorota, Renstr��m, Frida, Willems, Sara M., Mahajan, Anubha, Rose, Lynda M., Guo, Xiuqing, Liu, Yongmei, Kleber, Marcus E., P��russe, Louis, Gaunt, Tom, Ahluwalia, Tarunveer S., Sung, Yun Ju, Ramos, Yolande F., Amin, Najaf, Amuzu, Antoinette, Barroso, In��s, Bellis, Claire, Blangero, John, Buckley, Brendan M., B��hringer, Stefan, Chen, Yii-Der I., de Craen, Anton J. N., Crosslin, David R., Dale, Caroline E., Dastani, Zari, Day, Felix R., Deelen, Joris, Delgado, Graciela E., Demirkan, Ayse, Finucane, Francis M., Ford, Ian, Garcia, Melissa E., Gieger, Christian, Gustafsson, Stefan, Hallmans, G��ran, Hankinson, Susan E., Havulinna, Aki S., Herder, Christian, Hernandez, Dena, Hicks, Andrew A., Hunter, David J., Illig, Thomas, Ingelsson, Erik, Ioan-Facsinay, Andreea, Jansson, John-Olov, Jenny, Nancy S., J��rgensen, Marit E., J��rgensen, Torben, Karlsson, Magnus, Koenig, Wolfgang, Kraft, Peter, Kwekkeboom, Joanneke, Laatikainen, Tiina, Ladwig, Karl-Heinz, LeDuc, Charles A., Lowe, Gordon, Lu, Yingchang, Marques-Vidal, Pedro, Meisinger, Christa, Menni, Cristina, Morris, Andrew P., Myers, Richard H., M��nnist��, Satu, Nalls, Mike A., Paternoster, Lavinia, Peters, Annette, Pradhan, Aruna D., Rankinen, Tuomo, Rasmussen-Torvik, Laura J., Rathmann, Wolfgang, Rice, Treva K., Richards, J. Brent, Ridker, Paul M., Sattar, Naveed, Savage, David B., S��derberg, Stefan, Timpson, Nicholas J., Vandenput, Liesbeth, van Heemst, Diana, Uh, Hae-Won, Vohl, Marie-Claude, Walker, Mark, Wichmann, Heinz-Erich, Wid��n, Elisabeth, Wood, Andrew R., Yao, Jie, Zeller, Tanja, Zhang, Yiying, Meulenbelt, Ingrid, Kloppenburg, Margreet, Astrup, Arne, S��rensen, Thorkild I. A., Sarzynski, Mark A., Rao, D. C., Jousilahti, Pekka, Vartiainen, Erkki, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, Andr�� G., Kajantie, Eero, Osmond, Clive, Palotie, Aarno, Eriksson, Johan G., Heli��vaara, Markku, Knekt, Paul B., Koskinen, Seppo, Jula, Antti, Perola, Markus, Huupponen, Risto K., Viikari, Jorma S., K��h��nen, Mika, Lehtim��ki, Terho, Raitakari, Olli T., Mellstr��m, Dan, Lorentzon, Mattias, Casas, Juan P., Bandinelli, Stefanie, M��rz, Winfried, Isaacs, Aaron, van Dijk, Ko W., van Duijn, Cornelia M., Harris, Tamara B., Bouchard, Claude, Allison, Matthew A., Chasman, Daniel I., Ohlsson, Claes, Lind, Lars, Scott, Robert A., Langenberg, Claudia, Wareham, Nicholas J., Ferrucci, Luigi, Frayling, Timothy M., Pramstaller, Peter P., Borecki, Ingrid B., Waterworth, Dawn M., Bergmann, Sven, Waeber, G��rard, and Vollenweider, Peter
Subjects: Leptin, Meta-analysis, Molecular biology, FOS: Biological sciences, digestive, oral, and skin physiology, Genetics, hormones, hormone substitutes, and hormone antagonists
Abstract: Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P
Published: 2016
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236. A Noncoding Variant Near PPP1R3BPromotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction

Author: Kahali, Bratati, Chen, Yue, Feitosa, Mary F, Bielak, Lawrence F, O’Connell, Jeffrey R, Musani, Solomon K, Hegde, Yash, Chen, Yanhua, Stetson, L C, Guo, Xiuqing, Fu, Yi-ping, Smith, Albert Vernon, Ryan, Kathleen A, Eiriksdottir, Gudny, Cohain, Ariella T, Allison, Matthew, Bakshi, Andrew, Bowden, Donald W, Budoff, Matthew J, Carr, J Jeffrey, Carskadon, Shannon, Chen, Yii-Der I, Correa, Adolfo, Crudup, Breland F, Du, Xiaomeng, Harris, Tamara B, Yang, Jian, Kardia, Sharon L R, Launer, Lenore J, Liu, Jiankang, Mosley, Thomas H, Norris, Jill M, Terry, James G, Palanisamy, Nallasivam, Schadt, Eric E, O’Donnell, Christopher J, Yerges-Armstrong, Laura M, Rotter, Jerome I, Wagenknecht, Lynne E, Handelman, Samuel K, Gudnason, Vilmundur, Province, Michael A, Peyser, Patricia A, Halligan, Brian, Palmer, Nicholette D, and Speliotes, Elizabeth K
Published: 2021
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237. Multiethnic meta-analysis identifies new loci for pulmonary function

Author: Wyss, Annah B., primary, Sofer, Tamar, additional, Lee, Mi Kyeong, additional, Terzikhan, Natalie, additional, Nguyen, Jennifer N., additional, Lahousse, Lies, additional, Latourelle, Jeanne C., additional, Smith, Albert Vernon, additional, Bartz, Traci M., additional, Feitosa, Mary F., additional, Gao, Wei, additional, Ahluwalia, Tarunveer S., additional, Tang, Wenbo, additional, Oldmeadow, Christopher, additional, Duan, Qing, additional, Jong, Kim de, additional, Wojczynski, Mary K., additional, Wang, Xin-Qun, additional, Noordam, Raymond, additional, Hartwig, Fernando Pires, additional, Jackson, Victoria E., additional, Wang, Tianyuan, additional, Obeidat, Ma’en, additional, Hobbs, Brian D., additional, Huan, Tianxiao, additional, Kichaev, Gleb, additional, Jin, Jianping, additional, Graff, Mariaelisa, additional, Harris, Tamara B., additional, Kalhan, Ravi, additional, Heckbert, Susan R., additional, Paternoster, Lavinia, additional, Burkart, Kristin M., additional, Liu, Yongmei, additional, Holliday, Elizabeth G., additional, Wilson, James G., additional, Vonk, Judith M., additional, Sanders, Jason, additional, Barr, R. Graham, additional, Mutsert, Renée de, additional, Menezes, Ana Maria Baptista, additional, Adams, Hieab H. H., additional, Berge, Maarten van den, additional, Joehanes, Roby, additional, Launer, Lenore J., additional, Morrison, Alanna C., additional, Sitlani, Colleen M., additional, Celedón, Juan C., additional, Kritchevsky, Stephen B., additional, Scott, Rodney J., additional, Christensen, Kaare, additional, Rotter, Jerome I., additional, Bonten, Tobias N., additional, César Wehrmeister, Fernando, additional, Bossé, Yohan, additional, Franceschini, Nora, additional, Brody, Jennifer A., additional, Kaplan, Robert C., additional, Lohman, Kurt, additional, McEvoy, Mark, additional, Province, Michael A., additional, Rosendaal, Frits R., additional, Taylor, Kent D., additional, Nickle, David C., additional, North, Kari E., additional, Fornage, Myriam, additional, Psaty, Bruce M., additional, Myers, Richard H., additional, O’Connor, George, additional, Hansen, Torben, additional, Laurie, Cathy C., additional, Cassano, Pat, additional, Sung, Joohon, additional, Kim, Woo Jin, additional, Attia, John R., additional, Lange, Leslie, additional, Boezen, H. Marike, additional, Thyagarajan, Bharat, additional, Rich, Stephen S., additional, Mook-Kanamori, Dennis O., additional, Horta, Bernardo Lessa, additional, Uitterlinden, André G, additional, Sin, Don D., additional, Im, Hae Kyung, additional, Cho, Michael H., additional, Brusselle, Guy G., additional, Gharib, Sina A., additional, Dupuis, Josée, additional, Manichaikul, Ani, additional, and London, Stephanie J., additional
Published: 2017
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238. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Author: Macé, Aurélien, primary, Tuke, Marcus A., additional, Deelen, Patrick, additional, Kristiansson, Kati, additional, Mattsson, Hannele, additional, Nõukas, Margit, additional, Sapkota, Yadav, additional, Schick, Ursula, additional, Porcu, Eleonora, additional, Rüeger, Sina, additional, McDaid, Aaron F., additional, Porteous, David, additional, Winkler, Thomas W., additional, Salvi, Erika, additional, Shrine, Nick, additional, Liu, Xueping, additional, Ang, Wei Q., additional, Zhang, Weihua, additional, Feitosa, Mary F., additional, Venturini, Cristina, additional, van der Most, Peter J., additional, Rosengren, Anders, additional, Wood, Andrew R., additional, Beaumont, Robin N., additional, Jones, Samuel E., additional, Ruth, Katherine S., additional, Yaghootkar, Hanieh, additional, Tyrrell, Jessica, additional, Havulinna, Aki S., additional, Boers, Harmen, additional, Mägi, Reedik, additional, Kriebel, Jennifer, additional, Müller-Nurasyid, Martina, additional, Perola, Markus, additional, Nieminen, Markku, additional, Lokki, Marja-Liisa, additional, Kähönen, Mika, additional, Viikari, Jorma S., additional, Geller, Frank, additional, Lahti, Jari, additional, Palotie, Aarno, additional, Koponen, Päivikki, additional, Lundqvist, Annamari, additional, Rissanen, Harri, additional, Bottinger, Erwin P., additional, Afaq, Saima, additional, Wojczynski, Mary K., additional, Lenzini, Petra, additional, Nolte, Ilja M., additional, Sparsø, Thomas, additional, Schupf, Nicole, additional, Christensen, Kaare, additional, Perls, Thomas T., additional, Newman, Anne B., additional, Werge, Thomas, additional, Snieder, Harold, additional, Spector, Timothy D., additional, Chambers, John C., additional, Koskinen, Seppo, additional, Melbye, Mads, additional, Raitakari, Olli T., additional, Lehtimäki, Terho, additional, Tobin, Martin D., additional, Wain, Louise V., additional, Sinisalo, Juha, additional, Peters, Annette, additional, Meitinger, Thomas, additional, Martin, Nicholas G., additional, Wray, Naomi R., additional, Montgomery, Grant W., additional, Medland, Sarah E., additional, Swertz, Morris A., additional, Vartiainen, Erkki, additional, Borodulin, Katja, additional, Männistö, Satu, additional, Murray, Anna, additional, Bochud, Murielle, additional, Jacquemont, Sébastien, additional, Rivadeneira, Fernando, additional, Hansen, Thomas F., additional, Oldehinkel, Albertine J., additional, Mangino, Massimo, additional, Province, Michael A., additional, Deloukas, Panos, additional, Kooner, Jaspal S., additional, Freathy, Rachel M., additional, Pennell, Craig, additional, Feenstra, Bjarke, additional, Strachan, David P., additional, Lettre, Guillaume, additional, Hirschhorn, Joel, additional, Cusi, Daniele, additional, Heid, Iris M., additional, Hayward, Caroline, additional, Männik, Katrin, additional, Beckmann, Jacques S., additional, Loos, Ruth J. F., additional, Nyholt, Dale R., additional, Metspalu, Andres, additional, Eriksson, Johan G., additional, Weedon, Michael N., additional, Salomaa, Veikko, additional, Franke, Lude, additional, Reymond, Alexandre, additional, Frayling, Timothy M., additional, and Kutalik, Zoltán, additional
Published: 2017
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239. Abstract P530: Pleiotropic Effects on Blood Pressure Traits Using Genome-wide Analysis of Gene-alcohol Interactions

Author: Kraja, Aldi T, primary, Feitosa, Mary F, additional, Chasman, Daniel, additional, Sung, Yun J, additional, Winkler, Thomas W, additional, Ntalla, Ioanna, additional, Aschard, Hugues, additional, Rice, Kenneth, additional, Manning, Alisa K, additional, O’Connell, Jeffrey, additional, Kardia, Sharon L, additional, Munroe, Patricia, additional, Cupples, L. Adrienne, additional, Morrison, Alana, additional, Gauderman, W. James, additional, Levy, Daniel, additional, Rao, D.C., additional, Zhu, Xiaofeng, additional, Province, Michael A, additional, CHARGE Gene-Lifestyle Interactions, on behalf of the, additional, and the NHLBI grant HL 118305, This work is supported in part by, additional
Published: 2017
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240. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

Author: Saleheen, Danish, primary, Zhao, Wei, additional, Young, Robin, additional, Nelson, Christopher P., additional, Ho, WeangKee, additional, Ferguson, Jane F., additional, Rasheed, Asif, additional, Ou, Kristy, additional, Nurnberg, Sylvia T., additional, Bauer, Robert C., additional, Goel, Anuj, additional, Do, Ron, additional, Stewart, Alexandre F.R., additional, Hartiala, Jaana, additional, Zhang, Weihua, additional, Thorleifsson, Gudmar, additional, Strawbridge, Rona J., additional, Sinisalo, Juha, additional, Kanoni, Stavroula, additional, Sedaghat, Sanaz, additional, Marouli, Eirini, additional, Kristiansson, Kati, additional, Hua Zhao, Jing, additional, Scott, Robert, additional, Gauguier, Dominique, additional, Shah, Svati H., additional, Smith, Albert Vernon, additional, van Zuydam, Natalie, additional, Cox, Amanda J., additional, Willenborg, Christina, additional, Kessler, Thorsten, additional, Zeng, Lingyao, additional, Province, Michael A., additional, Ganna, Andrea, additional, Lind, Lars, additional, Pedersen, Nancy L., additional, White, Charles C., additional, Joensuu, Anni, additional, Edi Kleber, Marcus, additional, Hall, Alistair S., additional, März, Winfried, additional, Salomaa, Veikko, additional, O’Donnell, Christopher, additional, Ingelsson, Erik, additional, Feitosa, Mary F., additional, Erdmann, Jeanette, additional, Bowden, Donald W., additional, Palmer, Colin N.A., additional, Gudnason, Vilmundur, additional, Faire, Ulf De, additional, Zalloua, Pierre, additional, Wareham, Nicholas, additional, Thompson, John R., additional, Kuulasmaa, Kari, additional, Dedoussis, George, additional, Perola, Markus, additional, Dehghan, Abbas, additional, Chambers, John C., additional, Kooner, Jaspal, additional, Allayee, Hooman, additional, Deloukas, Panos, additional, McPherson, Ruth, additional, Stefansson, Kari, additional, Schunkert, Heribert, additional, Kathiresan, Sekar, additional, Farrall, Martin, additional, Marcel Frossard, Philippe, additional, Rader, Daniel J., additional, Samani, Nilesh J., additional, and Reilly, Muredach P., additional
Published: 2017
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241. Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Author: Gorski, Mathias, primary, Most, Peter J. van der, additional, Teumer, Alexander, additional, Chu, Audrey Y., additional, Li, Man, additional, Mijatovic, Vladan, additional, Nolte, Ilja M., additional, Cocca, Massimiliano, additional, Taliun, Daniel, additional, Gomez, Felicia, additional, Li, Yong, additional, Tayo, Bamidele, additional, Tin, Adrienne, additional, Feitosa, Mary F., additional, Aspelund, Thor, additional, Attia, John, additional, Biffar, Reiner, additional, Bochud, Murielle, additional, Boerwinkle, Eric, additional, Borecki, Ingrid, additional, Bottinger, Erwin P., additional, Chen, Ming-Huei, additional, Chouraki, Vincent, additional, Ciullo, Marina, additional, Coresh, Josef, additional, Cornelis, Marilyn C., additional, Curhan, Gary C., additional, Adamo, Adamo Pio d’, additional, Dehghan, Abbas, additional, Dengler, Laura, additional, Ding, Jingzhong, additional, Eiriksdottir, Gudny, additional, Endlich, Karlhans, additional, Enroth, Stefan, additional, Esko, Tõnu, additional, Franco, Oscar H., additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Girotto, Giorgia, additional, Gottesman, Omri, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hancock, Stephen J., additional, Harris, Tamara B., additional, Helmer, Catherine, additional, Höllerer, Simon, additional, Hofer, Edith, additional, Hofman, Albert, additional, Holliday, Elizabeth G., additional, Homuth, Georg, additional, Hu, Frank B., additional, Huth, Cornelia, additional, Hutri-Kähönen, Nina, additional, Hwang, Shih-Jen, additional, Imboden, Medea, additional, Johansson, Åsa, additional, Kähönen, Mika, additional, König, Wolfgang, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kumar, Ashish, additional, Kutalik, Zoltan, additional, Lambert, Jean-Charles, additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, de Borst, Martin H., additional, Navis, Gerjan, additional, Swertz, Morris, additional, Liu, Yongmei, additional, Lohman, Kurt, additional, Loos, Ruth J. F., additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, McEvoy, Mark A., additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Metzger, Marie, additional, Mihailov, Evelin, additional, Mitchell, Paul, additional, Nauck, Matthias, additional, Oldehinkel, Albertine J., additional, Olden, Matthias, additional, WJH Penninx, Brenda, additional, Pistis, Giorgio, additional, Pramstaller, Peter P., additional, Probst-Hensch, Nicole, additional, Raitakari, Olli T., additional, Rettig, Rainer, additional, Ridker, Paul M., additional, Rivadeneira, Fernando, additional, Robino, Antonietta, additional, Rosas, Sylvia E., additional, Ruderfer, Douglas, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sala, Cinzia, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Scott, Rodney J., additional, Sedaghat, Sanaz, additional, Smith, Albert V., additional, Sorice, Rossella, additional, Stengel, Benedicte, additional, Stracke, Sylvia, additional, Strauch, Konstantin, additional, Toniolo, Daniela, additional, Uitterlinden, Andre G., additional, Ulivi, Sheila, additional, Viikari, Jorma S., additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Vuckovic, Dragana, additional, Waldenberger, Melanie, additional, Wang, Jie Jin, additional, Yang, Qiong, additional, Chasman, Daniel I., additional, Tromp, Gerard, additional, Snieder, Harold, additional, Heid, Iris M., additional, Fox, Caroline S., additional, Köttgen, Anna, additional, Pattaro, Cristian, additional, Böger, Carsten A., additional, and Fuchsberger, Christian, additional
Published: 2017
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242. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author: Justice, Anne E., primary, Winkler, Thomas W., additional, Feitosa, Mary F., additional, Graff, Misa, additional, Fisher, Virginia A., additional, Young, Kristin, additional, Barata, Llilda, additional, Deng, Xuan, additional, Czajkowski, Jacek, additional, Hadley, David, additional, Ngwa, Julius S., additional, Ahluwalia, Tarunveer S., additional, Chu, Audrey Y., additional, Heard-Costa, Nancy L., additional, Lim, Elise, additional, Perez, Jeremiah, additional, Eicher, John D., additional, Kutalik, Zoltán, additional, Xue, Luting, additional, Mahajan, Anubha, additional, Renström, Frida, additional, Wu, Joseph, additional, Qi, Qibin, additional, Ahmad, Shafqat, additional, Alfred, Tamuno, additional, Amin, Najaf, additional, Bielak, Lawrence F., additional, Bonnefond, Amelie, additional, Bragg, Jennifer, additional, Cadby, Gemma, additional, Chittani, Martina, additional, Coggeshall, Scott, additional, Corre, Tanguy, additional, Direk, Nese, additional, Eriksson, Joel, additional, Fischer, Krista, additional, Gorski, Mathias, additional, Neergaard Harder, Marie, additional, Horikoshi, Momoko, additional, Huang, Tao, additional, Huffman, Jennifer E., additional, Jackson, Anne U., additional, Justesen, Johanne Marie, additional, Kanoni, Stavroula, additional, Kinnunen, Leena, additional, Kleber, Marcus E., additional, Komulainen, Pirjo, additional, Kumari, Meena, additional, Lim, Unhee, additional, Luan, Jian'an, additional, Lyytikäinen, Leo-Pekka, additional, Mangino, Massimo, additional, Manichaikul, Ani, additional, Marten, Jonathan, additional, Middelberg, Rita P. S., additional, Müller-Nurasyid, Martina, additional, Navarro, Pau, additional, Pérusse, Louis, additional, Pervjakova, Natalia, additional, Sarti, Cinzia, additional, Smith, Albert Vernon, additional, Smith, Jennifer A., additional, Stančáková, Alena, additional, Strawbridge, Rona J., additional, Stringham, Heather M., additional, Sung, Yun Ju, additional, Tanaka, Toshiko, additional, Teumer, Alexander, additional, Trompet, Stella, additional, van der Laan, Sander W., additional, van der Most, Peter J., additional, Van Vliet-Ostaptchouk, Jana V., additional, Vedantam, Sailaja L., additional, Verweij, Niek, additional, Vink, Jacqueline M., additional, Vitart, Veronique, additional, Wu, Ying, additional, Yengo, Loic, additional, Zhang, Weihua, additional, Hua Zhao, Jing, additional, Zimmermann, Martina E., additional, Zubair, Niha, additional, Abecasis, Gonçalo R., additional, Adair, Linda S., additional, Afaq, Saima, additional, Afzal, Uzma, additional, Bakker, Stephan J. L., additional, Bartz, Traci M., additional, Beilby, John, additional, Bergman, Richard N., additional, Bergmann, Sven, additional, Biffar, Reiner, additional, Blangero, John, additional, Boerwinkle, Eric, additional, Bonnycastle, Lori L., additional, Bottinger, Erwin, additional, Braga, Daniele, additional, Buckley, Brendan M., additional, Buyske, Steve, additional, Campbell, Harry, additional, Chambers, John C., additional, Collins, Francis S., additional, Curran, Joanne E., additional, de Borst, Gert J., additional, de Craen, Anton J. M., additional, de Geus, Eco J. C., additional, Dedoussis, George, additional, Delgado, Graciela E., additional, den Ruijter, Hester M., additional, Eiriksdottir, Gudny, additional, Eriksson, Anna L., additional, Esko, Tõnu, additional, Faul, Jessica D., additional, Ford, Ian, additional, Forrester, Terrence, additional, Gertow, Karl, additional, Gigante, Bruna, additional, Glorioso, Nicola, additional, Gong, Jian, additional, Grallert, Harald, additional, Grammer, Tanja B., additional, Grarup, Niels, additional, Haitjema, Saskia, additional, Hallmans, Göran, additional, Hamsten, Anders, additional, Hansen, Torben, additional, Harris, Tamara B., additional, Hartman, Catharina A., additional, Hassinen, Maija, additional, Hastie, Nicholas D., additional, Heath, Andrew C., additional, Hernandez, Dena, additional, Hindorff, Lucia, additional, Hocking, Lynne J., additional, Hollensted, Mette, additional, Holmen, Oddgeir L., additional, Homuth, Georg, additional, Jan Hottenga, Jouke, additional, Huang, Jie, additional, Hung, Joseph, additional, Hutri-Kähönen, Nina, additional, Ingelsson, Erik, additional, James, Alan L., additional, Jansson, John-Olov, additional, Jarvelin, Marjo-Riitta, additional, Jhun, Min A., additional, Jørgensen, Marit E., additional, Juonala, Markus, additional, Kähönen, Mika, additional, Karlsson, Magnus, additional, Koistinen, Heikki A., additional, Kolcic, Ivana, additional, Kolovou, Genovefa, additional, Kooperberg, Charles, additional, Krämer, Bernhard K., additional, Kuusisto, Johanna, additional, Kvaløy, Kirsti, additional, Lakka, Timo A., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Leander, Karin, additional, Lee, Nanette R., additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Linneberg, Allan, additional, Lobbens, Stephane, additional, Loh, Marie, additional, Lorentzon, Mattias, additional, Luben, Robert, additional, Lubke, Gitta, additional, Ludolph-Donislawski, Anja, additional, Lupoli, Sara, additional, Madden, Pamela A. F., additional, Männikkö, Reija, additional, Marques-Vidal, Pedro, additional, Martin, Nicholas G., additional, McKenzie, Colin A., additional, McKnight, Barbara, additional, Mellström, Dan, additional, Menni, Cristina, additional, Montgomery, Grant W., additional, Musk, AW, additional, Narisu, Narisu, additional, Nauck, Matthias, additional, Nolte, Ilja M., additional, Oldehinkel, Albertine J., additional, Olden, Matthias, additional, Ong, Ken K., additional, Padmanabhan, Sandosh, additional, Peyser, Patricia A., additional, Pisinger, Charlotta, additional, Porteous, David J., additional, Raitakari, Olli T., additional, Rankinen, Tuomo, additional, Rao, D. C., additional, Rasmussen-Torvik, Laura J., additional, Rawal, Rajesh, additional, Rice, Treva, additional, Ridker, Paul M., additional, Rose, Lynda M., additional, Bien, Stephanie A., additional, Rudan, Igor, additional, Sanna, Serena, additional, Sarzynski, Mark A., additional, Sattar, Naveed, additional, Savonen, Kai, additional, Schlessinger, David, additional, Scholtens, Salome, additional, Schurmann, Claudia, additional, Scott, Robert A., additional, Sennblad, Bengt, additional, Siemelink, Marten A., additional, Silbernagel, Günther, additional, Slagboom, P Eline, additional, Snieder, Harold, additional, Staessen, Jan A., additional, Stott, David J., additional, Swertz, Morris A., additional, Swift, Amy J., additional, Taylor, Kent D., additional, Tayo, Bamidele O., additional, Thorand, Barbara, additional, Thuillier, Dorothee, additional, Tuomilehto, Jaakko, additional, Uitterlinden, Andre G., additional, Vandenput, Liesbeth, additional, Vohl, Marie-Claude, additional, Völzke, Henry, additional, Vonk, Judith M., additional, Waeber, Gérard, additional, Waldenberger, Melanie, additional, Westendorp, R. G. J., additional, Wild, Sarah, additional, Willemsen, Gonneke, additional, Wolffenbuttel, Bruce H. R., additional, Wong, Andrew, additional, Wright, Alan F., additional, Zhao, Wei, additional, Zillikens, M Carola, additional, Baldassarre, Damiano, additional, Balkau, Beverley, additional, Bandinelli, Stefania, additional, Böger, Carsten A., additional, Boomsma, Dorret I., additional, Bouchard, Claude, additional, Bruinenberg, Marcel, additional, Chasman, Daniel I., additional, Chen, Yii-DerIda, additional, Chines, Peter S., additional, Cooper, Richard S., additional, Cucca, Francesco, additional, Cusi, Daniele, additional, Faire, Ulf de, additional, Ferrucci, Luigi, additional, Franks, Paul W., additional, Froguel, Philippe, additional, Gordon-Larsen, Penny, additional, Grabe, Hans- Jörgen, additional, Gudnason, Vilmundur, additional, Haiman, Christopher A., additional, Hayward, Caroline, additional, Hveem, Kristian, additional, Johnson, Andrew D., additional, Wouter Jukema, J, additional, Kardia, Sharon L. R., additional, Kivimaki, Mika, additional, Kooner, Jaspal S., additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Marchand, Loic Le, additional, März, Winfried, additional, McCarthy, Mark I., additional, Metspalu, Andres, additional, Morris, Andrew P., additional, Ohlsson, Claes, additional, Palmer, Lyle J., additional, Pasterkamp, Gerard, additional, Pedersen, Oluf, additional, Peters, Annette, additional, Peters, Ulrike, additional, Polasek, Ozren, additional, Psaty, Bruce M., additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Smith, Blair H., additional, Sørensen, Thorkild I. A., additional, Strauch, Konstantin, additional, Tiemeier, Henning, additional, Tremoli, Elena, additional, van der Harst, Pim, additional, Vestergaard, Henrik, additional, Vollenweider, Peter, additional, Wareham, Nicholas J., additional, Weir, David R., additional, Whitfield, John B., additional, Wilson, James F., additional, Tyrrell, Jessica, additional, Frayling, Timothy M., additional, Barroso, Inês, additional, Boehnke, Michael, additional, Deloukas, Panagiotis, additional, Fox, Caroline S., additional, Hirschhorn, Joel N., additional, Hunter, David J., additional, Spector, Tim D., additional, Strachan, David P., additional, van Duijn, Cornelia M., additional, Heid, Iris M., additional, Mohlke, Karen L., additional, Marchini, Jonathan, additional, Loos, Ruth J. F., additional, Kilpeläinen, Tuomas O., additional, Liu, Ching-Ti, additional, Borecki, Ingrid B., additional, North, Kari E., additional, and Cupples, L Adrienne, additional
Published: 2017
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243. Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

Author: van Leeuwen, Elisabeth M., Huffman, Jennifer E., Bis, Joshua C., Isaacs, Aaron, Mulder, Monique, Sabo, Aniko, Smith, Albert V., Demissie, Serkalem, Manichaikul, Ani, Brody, Jennifer A., Feitosa, Mary F., Duan, Qing, Schraut, Katharina E., Navarro, Pau, van Vliet-Ostaptchouk, Jana V., Zhu, Gu, Mbarek, Hamdi, Trompet, Stella, Verweij, Niek, Lyytikäinen, Leo Pekka, Deelen, Joris, Nolte, Ilja M., van der Laan, Sander W., Davies, Gail, Vermeij-Verdoold, Andrea J.M., van Oosterhout, Andy A.L.J., Vergeer-Drop, Jeannette M., Arking, Dan E., Trochet, Holly, Medina-Gomez, Carolina, Rivadeneira, Fernando, Uitterlinden, Andre G., Dehghan, Abbas, Franco, Oscar H., Sijbrands, Eric J., Hofman, Albert, White, Charles C., Mychaleckyj, Josyf C., Peloso, Gina M., Swertz, Morris A., Willemsen, Gonneke, de Geus, Eco J., Milaneschi, Yuri, Penninx, Brenda W.J.H., Ford, Ian, Buckley, Brendan M., de Craen, Anton J.M., Starr, John M., Deary, Ian J., Pasterkamp, Gerard, Generation Scotland, LifeLines Cohort Study, and CHARGE Lipids Working Group
Subjects: Ageing, Geriatrics and Gerontology
Abstract: BACKGROUND: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (CETP) gene. In this study, we investigate the association of CETP and HDL-C further to identify novel, independent CETP variants associated with HDL-C in humans. METHODS: We performed a meta-analysis of HDL-C within the CETP region using 59,432 individuals imputed with 1000 Genomes data. We performed replication in an independent sample of 47,866 individuals and validation was done by Sanger sequencing. RESULTS: The meta-analysis of HDL-C within the CETP region identified five independent variants, including an exonic variant and a common intronic insertion. We replicated these 5 variants significantly in an independent sample of 47,866 individuals. Sanger sequencing of the insertion within a single family confirmed segregation of this variant. The strongest reported association between HDL-C and CETP variants, was rs3764261; however, after conditioning on the five novel variants we identified the support for rs3764261 was highly reduced (βunadjusted = 3.179 mg/dl (P value = 5.25 × 10−509), βadjusted = 0.859 mg/dl (P value = 9.51 × 10− 25)), and this finding suggests that these five novel variants may partly explain the association of CETP with HDL-C. Indeed, three of the five novel variants (rs34065661, rs5817082, rs7499892) are independent of rs3764261. CONCLUSIONS: The causal variants in CETP that account for the association with HDL-C remain unknown. We used studies imputed to the 1000 Genomes reference panel for fine mapping of the CETP region. We identified and validated five variants within this region that may partly account for the association of the known variant (rs3764261), as well as other sources of genetic contribution to HDL-C.
Published: 2015

244. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study

Author: Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tonu, Fall, Tove, Kilpelainen, Tuomas O., Lu, Yingchang, Magi, Reedik, Mihailov, Evelin, Pers, Tune H., Rueeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C., Absher, Devin, Ahluwalia, Tarunveer S., Ahmad, Shafqat, Albrecht, Eva, Alves, Alexessander Couto, Bragg-Gresham, Jennifer L., de Craen, Anton J. M., Bis, Joshua C., Bonnefond, Amelie, Boucher, Gabrielle, Cadby, Gemma, Cheng, Yu-Ching, Chiang, Charleston W. K., Haitjema, Saskia, van der Laan, Sander W., van Setten, Jessica, Asselbergs, Folkert W., de Bakker, Paul I. W., Moll, Frans L., Pasterkamp, Gerard, den Ruijter, Hester M., CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, and MAGIC Consortium
Subjects: COMMON SNPS, LIFE-COURSE, MASS INDEX, SELF-REPORTED HEIGHT, BIOLOGICAL PATHWAYS, LOCI, FAT DISTRIBUTION, NATURAL MENOPAUSE, PERIPHERAL-BLOOD, WEIGHT-GAIN
Abstract: Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
Published: 2015

245. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians12

Author: Fretts, Amanda M, Follis, Jack L, Nettleton, Jennifer A, Lemaitre, Rozenn N, Ngwa, Julius S, Wojczynski, Mary K, Kalafati, Ioanna Panagiota, Varga, Tibor V, Frazier-Wood, Alexis C, Houston, Denise K, Lahti, Jari, Ericson, Ulrika, van den Hooven, Edith H, Mikkilä, Vera, Kiefte-de Jong, Jessica C, Mozaffarian, Dariush, Rice, Kenneth, Renström, Frida, North, Kari E, McKeown, Nicola M, Feitosa, Mary F, Kanoni, Stavroula, Smith, Caren E, Garcia, Melissa E, Tiainen, Anna-Maija, Sonestedt, Emily, Manichaikul, Ani, van Rooij, Frank JA, Dimitriou, Maria, Raitakari, Olli, Pankow, James S, Djoussé, Luc, Province, Michael A, Hu, Frank B, Lai, Chao-Qiang, Keller, Margaux F, Perälä, Mia-Maria, Rotter, Jerome I, Hofman, Albert, Graff, Misa, Kähönen, Mika, Mukamal, Kenneth, Johansson, Ingegerd, Ordovas, Jose M, Liu, Yongmei, Männistö, Satu, Uitterlinden, André G, Deloukas, Panos, Seppälä, Ilkka, Psaty, Bruce M, Cupples, L Adrienne, Borecki, Ingrid B, Franks, Paul W, Arnett, Donna K, Nalls, Mike A, Eriksson, Johan G, Orho-Melander, Marju, Franco, Oscar H, Lehtimäki, Terho, Dedoussis, George V, Meigs, James B, and Siscovick, David S
Subjects: Blood Glucose, Meat, Gene-Nutrient Interactions, food and beverages, Middle Aged, Polymorphism, Single Nucleotide, Cohort Studies, Meat Products, Risk Factors, Hyperglycemia, Hyperinsulinism, Insulin-Secreting Cells, Insulin Secretion, Humans, Insulin, Genetic Predisposition to Disease, Insulin Resistance, Genetic Association Studies, Genome-Wide Association Study
Abstract: Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.We investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus.Fourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined 1) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations.Processed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049-ln-pmol/L (95% CI: 0.035, 0.063-ln-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic loci known to influence fasting glucose or insulin resistance.The association of higher fasting glucose and insulin concentrations with meat consumption was not modified by an index of glucose- and insulin-related single-nucleotide polymorphisms. Six of the participating studies are registered at clinicaltrials.gov as NCT0000513 (Atherosclerosis Risk in Communities), NCT00149435 (Cardiovascular Health Study), NCT00005136 (Family Heart Study), NCT00005121 (Framingham Heart Study), NCT00083369 (Genetics of Lipid Lowering Drugs and Diet Network), and NCT00005487 (Multi-Ethnic Study of Atherosclerosis).
Published: 2015

246. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

Author: Chu, Audrey Y, primary, Deng, Xuan, additional, Fisher, Virginia A, additional, Drong, Alexander, additional, Zhang, Yang, additional, Feitosa, Mary F, additional, Liu, Ching-Ti, additional, Weeks, Olivia, additional, Choh, Audrey C, additional, Duan, Qing, additional, Dyer, Thomas D, additional, Eicher, John D, additional, Guo, Xiuqing, additional, Heard-Costa, Nancy L, additional, Kacprowski, Tim, additional, Kent, Jack W, additional, Lange, Leslie A, additional, Liu, Xinggang, additional, Lohman, Kurt, additional, Lu, Lingyi, additional, Mahajan, Anubha, additional, O'Connell, Jeffrey R, additional, Parihar, Ankita, additional, Peralta, Juan M, additional, Smith, Albert V, additional, Zhang, Yi, additional, Homuth, Georg, additional, Kissebah, Ahmed H, additional, Kullberg, Joel, additional, Laqua, René, additional, Launer, Lenore J, additional, Nauck, Matthias, additional, Olivier, Michael, additional, Peyser, Patricia A, additional, Terry, James G, additional, Wojczynski, Mary K, additional, Yao, Jie, additional, Bielak, Lawrence F, additional, Blangero, John, additional, Borecki, Ingrid B, additional, Bowden, Donald W, additional, Carr, John Jeffrey, additional, Czerwinski, Stefan A, additional, Ding, Jingzhong, additional, Friedrich, Nele, additional, Gudnason, Vilmunder, additional, Harris, Tamara B, additional, Ingelsson, Erik, additional, Johnson, Andrew D, additional, Kardia, Sharon L R, additional, Langefeld, Carl D, additional, Lind, Lars, additional, Liu, Yongmei, additional, Mitchell, Braxton D, additional, Morris, Andrew P, additional, Mosley, Thomas H, additional, Rotter, Jerome I, additional, Shuldiner, Alan R, additional, Towne, Bradford, additional, Völzke, Henry, additional, Wallaschofski, Henri, additional, Wilson, James G, additional, Allison, Matthew, additional, Lindgren, Cecilia M, additional, Goessling, Wolfram, additional, Cupples, L Adrienne, additional, Steinhauser, Matthew L, additional, and Fox, Caroline S, additional
Published: 2016
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247. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

Author: Natarajan, Pradeep, primary, Bis, Joshua C., additional, Bielak, Lawrence F., additional, Cox, Amanda J., additional, Dörr, Marcus, additional, Feitosa, Mary F., additional, Franceschini, Nora, additional, Guo, Xiuqing, additional, Hwang, Shih-Jen, additional, Isaacs, Aaron, additional, Jhun, Min A, additional, Kavousi, Maryam, additional, Li-Gao, Ruifang, additional, Lyytikäinen, Leo-Pekka, additional, Marioni, Riccardo E., additional, Schminke, Ulf, additional, Stitziel, Nathan O., additional, Tada, Hayato, additional, van Setten, Jessica, additional, Smith, Albert V., additional, Vojinovic, Dina, additional, Yanek, Lisa R., additional, Yao, Jie, additional, Yerges-Armstrong, Laura M., additional, Amin, Najaf, additional, Baber, Usman, additional, Borecki, Ingrid B., additional, Carr, J. Jeffrey, additional, Chen, Yii-Der Ida, additional, Cupples, L. Adrienne, additional, de Jong, Pim A., additional, de Koning, Harry, additional, de Vos, Bob D., additional, Demirkan, Ayse, additional, Fuster, Valentin, additional, Franco, Oscar H., additional, Goodarzi, Mark O., additional, Harris, Tamara B., additional, Heckbert, Susan R., additional, Heiss, Gerardo, additional, Hoffmann, Udo, additional, Hofman, Albert, additional, Išgum, Ivana, additional, Jukema, J. Wouter, additional, Kähönen, Mika, additional, Kardia, Sharon L.R., additional, Kral, Brian G., additional, Launer, Lenore J., additional, Massaro, Joe, additional, Mehran, Roxana, additional, Mitchell, Braxton D., additional, Mosley, Thomas H., additional, de Mutsert, Renée, additional, Newman, Anne B., additional, Nguyen, Khanh-dung, additional, North, Kari E., additional, O’Connell, Jeffrey R., additional, Oudkerk, Matthijs, additional, Pankow, James S., additional, Peloso, Gina M., additional, Post, Wendy, additional, Province, Michael A., additional, Raffield, Laura M., additional, Raitakari, Olli T., additional, Reilly, Dermot F., additional, Rivadeneira, Fernando, additional, Rosendaal, Frits, additional, Sartori, Samantha, additional, Taylor, Kent D., additional, Teumer, Alexander, additional, Trompet, Stella, additional, Turner, Stephen T., additional, Uitterlinden, Andre G., additional, Vaidya, Dhananjay, additional, van der Lugt, Aad, additional, Völker, Uwe, additional, Wardlaw, Joanna M., additional, Wassel, Christina L., additional, Weiss, Stefan, additional, Wojczynski, Mary K., additional, Becker, Diane M., additional, Becker, Lewis C., additional, Boerwinkle, Eric, additional, Bowden, Donald W., additional, Deary, Ian J., additional, Dehghan, Abbas, additional, Felix, Stephan B., additional, Gudnason, Vilmundur, additional, Lehtimäki, Terho, additional, Mathias, Rasika, additional, Mook-Kanamori, Dennis O., additional, Psaty, Bruce M., additional, Rader, Daniel J., additional, Rotter, Jerome I., additional, Wilson, James G., additional, van Duijn, Cornelia M., additional, Völzke, Henry, additional, Kathiresan, Sekar, additional, Peyser, Patricia A., additional, and O’Donnell, Christopher J., additional
Published: 2016
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248. Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

Author: Pulit, Sara L., Deelen, Patrick, van Enckevort, David J., Leach, Irene Mateo, Peloso, Gina M., Feitosa, Mary F., Isaacs, Aaron, van Dijk, Freerk, Hofman, Albert, Kanterakis, Alexandros, Penninx, Brenda W.J.H., Oostra, Ben A., de Geus, Eco J., Karssen, Lennart C., Willemsen, Gonneke, Postmus, Iris, Mbarek, Hamdi, Huffman, Jennifer E., Bartz, Traci M., van Leeuwen, Elisabeth M., Joshi, Peter K., Medina-Gomez, Carolina, Menelaou, Androniki, White, Charles C., Verweij, Niek, Manichaikul, Ani, Rivadeneira, Fernando, Milaneschi, Yuri, Francioli, Laurent C., Deelen, Joris, Trompet, Stella, and Franco, Oscar H.
Abstract: Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value
Published: 2015
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249. multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

Author: Sung, Yun Ju, de las Fuentes, Lisa, Winkler, Thomas W, Chasman, Daniel I, Bentley, Amy R, Kraja, Aldi T, Ntalla, Ioanna, Warren, Helen R, Guo, Xiuqing, Schwander, Karen, Manning, Alisa K, Brown, Michael R, Aschard, Hugues, Feitosa, Mary F, Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, and Marten, Jonathan
Published: 2019
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250. Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Author: Vries, Paul S de, Brown, Michael R, Bentley, Amy R, Sung, Yun J, Winkler, Thomas W, Ntalla, Ioanna, Schwander, Karen, Kraja, Aldi T, Guo, Xiuqing, Franceschini, Nora, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E, Musani, Solomon K, Li, Changwei, Feitosa, Mary F, Richard, Melissa A, Noordam, Raymond, and Aschard, Hugues
Subjects: APOLIPOPROTEINS, COMPARATIVE studies, ALCOHOL drinking, GENES, GENETICS, GENOMES, LIPIDS, META-analysis, PHENOTYPES, VASCULAR endothelial growth factors, LIFESTYLES
Abstract: A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014–November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2–degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10−6) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 × 10−8 using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models. [ABSTRACT FROM AUTHOR]
Published: 2019
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