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202. Guideline for PET/CT imaging of neuroendocrine neoplasms with Ga-68-DOTA-conjugated somatostatin receptor targeting peptides and F-18-DOPA

Author

Bozkurt, Murat Fani, Virgolini, Irene, Balogova, Sona, Beheshti, Mohsen, Rubello, Domenico, Decristoforo, Clemens, Ambrosini, Valentina, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim J. G., Chiti, Arturo, Giammarile, Francesco, Sundin, Anders, Fanti, Stefano, Bozkurt, Murat Fani, Virgolini, Irene, Balogova, Sona, Beheshti, Mohsen, Rubello, Domenico, Decristoforo, Clemens, Ambrosini, Valentina, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim J. G., Chiti, Arturo, Giammarile, Francesco, Sundin, Anders, and Fanti, Stefano

Abstract

Purpose & Methods Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline is aimed to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin receptor (SSTR) PET/CT imaging using Ga-68-DOTA-conjugated peptides, as well as F-18-DOPA imaging for various neuroendocrine neoplasms. Results & Conclusion The previous procedural guideline by EANM regarding the use PET/CT tumour imaging with Ga-68-conjugated peptides has been revised and updated with the relevant and recent literature in the field with contribution of distinguished experts., Correction in: Eur J Nucl Med Mol Imaging (2017) 44: 2150DOI: 10.1007/s00259-017-3807-0Professor Anders Sundin’s name was not included among the authors’ list even though he contributed to the article with all the great efforts and valuable expertise on the field, which all of the authors of this article absolutely agree with and approve that his name should have been among the authors for this article.

Published
2017
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203. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : Radiological, Nuclear Medicine & Hybrid Imaging.

Author

Sundin, Anders, Arnold, Rudolf, Baudin, Eric, Cwikla, Jaroslaw B, Eriksson, Barbro, Fanti, Stefano, Fazio, Nicola, Giammarile, Francesco, Hicks, Rodney J, Kjaer, Andreas, Krenning, Eric, Kwekkeboom, Dik, Lombard-Bohas, Catherine, O'Connor, Juan M, O'Toole, Dermot, Rockall, Andrea, Wiedenmann, Bertram, Valle, Juan W, Vullierme, Marie-Pierre, Sundin, Anders, Arnold, Rudolf, Baudin, Eric, Cwikla, Jaroslaw B, Eriksson, Barbro, Fanti, Stefano, Fazio, Nicola, Giammarile, Francesco, Hicks, Rodney J, Kjaer, Andreas, Krenning, Eric, Kwekkeboom, Dik, Lombard-Bohas, Catherine, O'Connor, Juan M, O'Toole, Dermot, Rockall, Andrea, Wiedenmann, Bertram, Valle, Juan W, and Vullierme, Marie-Pierre

Abstract

Contrast-enhanced computed tomography (CT) of the neckthorax-abdomen and pelvis, including 3-phase examination of the liver, constitutes the basic imaging for primary neuroendocrine tumor (NET) diagnosis, staging, surveillance, and therapy monitoring. CT characterization of lymph nodes is difficult because of inadequate size criteria (short axis diameter), and bone metastases are often missed. Contrast-enhanced magnetic resonance imaging (MRI) including diffusion-weighted imaging is preferred for the examination of the liver, pancreas, brain and bone. MRI may miss small lung metastases. MRI is less well suited than CT for the examination of extended body areas because of the longer examination procedure. Ultrasonography (US) frequently provides the initial diagnosis of liver metastases and contrast-enhanced US is excellent to characterize liver lesions that remain equivocal on CT/MRI. US is the method of choice to guide the biopsy needle for the histopathological NET diagnosis. US cannot visualize thoracic NET lesions for which CTguided biopsy therefore is used. Endocopic US is the most sensitive method to diagnose pancreatic NETs, and additionally allows for biopsy. Intraoperative US facilitates lesion detection in the pancreas and liver. Somatostatin receptor imaging should be a part of the tumor staging, preoperative imaging and restaging, for which 68 Ga-DOTA-somatostatin analog PET/CT is recommended, which is vastly superior to somatostatin receptor scintigraphy, and facilitates the diagnosis of most types of NET lesions, for example lymph node metastases, bone metastases, liver metastases, peritoneal lesions, and primary small intestinal NETs. (18)FDG-PET/CT is better suited for G3 and high G2 NETs, which generally have higher glucose metabolism and less somatostatin receptor expression than low-grade NETs, and additionally provides prognostic information.

Published
2017
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204. Guideline for PET/CT imaging of neuroendocrine neoplasms withGa-DOTA-conjugated somatostatin receptor targeting peptides andF-DOPA

Author

Bozkurt, Murat Fani, Virgolini, Irene, Balogova, Sona, Beheshti, Mohsen, Rubello, Domenico, Decristoforo, Clemens, Ambrosini, Valentina, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim J G, Chiti, Arturo, Giammarile, Francesco, Fanti, Stefano, Bozkurt, Murat Fani, Virgolini, Irene, Balogova, Sona, Beheshti, Mohsen, Rubello, Domenico, Decristoforo, Clemens, Ambrosini, Valentina, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim J G, Chiti, Arturo, Giammarile, Francesco, and Fanti, Stefano

Abstract

PURPOSE & METHODS: Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline is aimed to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin receptor (SSTR) PET/CT imaging using68Ga-DOTA-conjugated peptides, as well as18F-DOPA imaging for various neuroendocrine neoplasms.RESULTS & CONCLUSION: The previous procedural guideline by EANM regarding the use PET/CT tumour imaging with68Ga-conjugated peptides has been revised and updated with the relevant and recent literature in the field with contribution of distinguished experts.

Published
2017

205. Erratum to:Guideline for PET/CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F–DOPA (European Journal of Nuclear Medicine and Molecular Imaging, (2017), 44, 9, (1588-1601), 10.1007/s00259-017-3728-y)

Author

Bozkurt, Murat Fani, Virgolini, Irene, Balogova, Sona, Beheshti, Mohsen, Rubello, Domenico, Decristoforo, Clemens, Ambrosini, Valentina, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim J.G., Chiti, Arturo, Giammarile, Francesco, Sundin, Anders, Fanti, Stefano, Bozkurt, Murat Fani, Virgolini, Irene, Balogova, Sona, Beheshti, Mohsen, Rubello, Domenico, Decristoforo, Clemens, Ambrosini, Valentina, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim J.G., Chiti, Arturo, Giammarile, Francesco, Sundin, Anders, and Fanti, Stefano

Abstract

Unfortunately, due to some indeliberate and inadvertent reasons, Professor Anders Sundin’s name was not included among the authors’ list even though he contributed to the article with all the great efforts and valuable expertise on the field, which all of the authors of this article absolutely agree with and approve that his name should have been among the authors for this article.Professor Sundin contributed to the article with a meticulous review and made valuable additions to the manuscript. Since Professor Sundin is a practising radiologist, his contribution to this guideline was mainly focused on a radiological perspective of PET/CT imaging of neuroendocrine neoplasms and upon his suggestion, some key points from a radiological point of view was added to the manuscript. Professor Sundin’s scientific contribution to this guideline was really very important and had a great impact given the fact that neuroendocrine tumors are aheterogenous group of neoplasms for which an utmost multidisciplinary approach is definitely warranted. Professor Sundin not only contributed to the article in a scientific way and from a radiologist’s perspective but he also had a great contribution by means of English-language editing, due to his personal interest in the English language. All of the authors specifically confirm that Professor Sundin was substantially involved in all of the steps during this work. Professor Sundin made substantial contributions to the conception and design of the work; to the acquisition, analysis, and interpretation of data for the work; and to drafting the work and revising it critically for important intellectual content. Therefore, upon his important contribution to this guideline with his great efforts and distinctive expertise in the field, and on behalf of all of the authors and with their approvals, I hereby state that Professor Sundin’s name should have been among the authors for this article.

Published
2017

206. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

Author

Vilgrain, Valérie, primary, Pereira, Helena, additional, Assenat, Eric, additional, Guiu, Boris, additional, Ilonca, Alina Diana, additional, Pageaux, Georges-Philippe, additional, Sibert, Annie, additional, Bouattour, Mohamed, additional, Lebtahi, Rachida, additional, Allaham, Wassim, additional, Barraud, Hélène, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Bronowicki, Jean-Pierre, additional, Tasu, Jean-Pierre, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Gerolami, René, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Oberti, Frédéric, additional, Couturier, Olivier, additional, Brenot-Rossi, Isabelle, additional, Raoul, Jean-Luc, additional, Sarran, Anthony, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Luciani, Alain, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Ronot, Maxime, additional, Dinut, Aurelia, additional, Castera, Laurent, additional, Chatellier, Gilles, additional, Delhom - Christol, Elisabeth, additional, Ilonca, Alina D, additional, Lonjon, Julie, additional, Abdel-Rehim, Mohamed, additional, Dieudonné, Arnaud, additional, Vilgrain, Valérie, additional, Bazin, Christophe, additional, Chagneau-Derrode, Carine, additional, Borentain, Patrick, additional, Bouvier, Antoine, additional, Vervueren, Laurent, additional, Chalaye, Julia, additional, Kobeiter, Hicham, additional, Edeline, Julien, additional, Garin, Etienne, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Detour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Leroy, Vincent, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Ganne-Carrie, Nathalie, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Pelage, Jean-Pierre, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Ghazzar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Heurgue-Berlot, Alexandra, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2017
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207. Advances in radioguided surgery in oncology

Author

Valdés Olmos, Renato A., primary, Vidal-Sicart, Sergi, additional, Manca, Gianpiero, additional, Mariani, Giuliano, additional, León-Ramírez, Luisa F., additional, Rubello, Domenico, additional, and Giammarile, Francesco, additional

Published
2017
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210. Cat-Scratch Disease

Author

Dubreuil, Julien, primary, Dony, Arthur, additional, Salles, Gilles, additional, Traverse-Glehen, Alexandra, additional, Giammarile, Francesco, additional, and Skanjeti, Andrea, additional

Published
2017
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212. Sentinel Node Mapping in Gynecologic Cancers: A Comprehensive Review.

Author

Skanjeti, Andrea, Dhomps, Anthony, Paschetta, Cristina, Tordo, Jérémie, and Giammarile, Francesco

Abstract

Gynecologic cancers are one of the most important causes of women death worldwide. The sentinel lymph node concept was introduced by Cabanas in 1977 for the penile cancer. This technique was proven safe and feasible in selected cancers such as breast cancer, melanoma, or some gynecologic cancers. Sentinel lymph node mapping is increasingly used in early stages of cervical or vulvar cancer in particular due to the safety, high detection rate, and sensitivity of the technique. In this review, we will discuss in depth the most recent evidence of nuclear medicine and other techniques used to determine the status of the sentinel lymph node in women affected by gynecologic neoplasms. Although significant efforts have been already done in order to address several issues, there are still determined questions without a clear answer, in particular for endometrial, ovarian, and vaginal neoplasms. [ABSTRACT FROM AUTHOR]

Published
2019
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213. 18F-fluorodeoxyglucose positron emission tomography is useful for the diagnosis of intraocular sarcoidosis in patients with a normal CT scan.

Author

Chauvelot, Pierre, Skanjeti, Andrea, Jamilloux, Yvan, de Parisot, Audrey, Broussolle, Christiane, Denis, Philippe, Ramackers, Jean Marie, Giammarile, Francesco, Kodjikian, Laurent, and Seve, Pascal

Abstract

Aim To assess the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and the predictive factors for the diagnosis of sarcoidosis in patients with uveitis who have normal thoracic tomography. Methods We retrospectively reviewed 67 consecutive patients with uveitis of unknown aetiology or a suspected sarcoidosis. All patients with normal thoracic tomography underwent an 18F-FDG PET/CT, which was blindly reinterpreted. We then assessed the proportion of positive 18F-FDG PET/CT and the impact on the final aetiology, using Abad's criteria for the diagnosis of intraocular sarcoidosis. Results 19 of the 67 patients (28.4%) had mediastinal hypermetabolic foci on their 18F-FDG PET/CT consistent with sarcoidosis. It identified a biopsy site in two cases, which were consistent with sarcoidosis. At the end of the study, six patients (10%) had a proven sarcoidosis, six patients (9%) were considered as having a presumed sarcoidosis and 18 patients (26.9%) as having indeterminate sarcoidosis. 18F-FDG PET/CT enabled the diagnosis of presumed sarcoidosis in these six patients. An older age at diagnosis (p=0.004) and the presence of synechiae (p=0.02) were significantly related to an abnormal 18F-FDG PET/CT, with a trend for an elevated ACE (p=0.0993). We established a nomogram to estimate the probability of having positive findings on the 18F-FDG PET/CT according to different predictive factors. Conclusion 18F-FDG PET/CT enabled the diagnosis of intraocular sarcoidosis even in patients with a normal CT scan. Older age at diagnosis, presence of synechiae and elevated ACE are associated with positive findings on 18F-FDG PET/CT consistent with sarcoidosis. [ABSTRACT FROM AUTHOR]

Published
2019
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214. The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma.

Author

Giammarile, Francesco, Schilling, Clare, Gnanasegaran, Gopinanth, Bal, Chandrasckhar, Oyen, Wim J. G., Rubello, Domenico, Schwarz, Thomas, Tartaglione, Girolamo, Miller, Rodolfo Nuñez, Paez, Diana, van Leeuwen, Fijis W. B., Valdés Olmos, Renato A., McGurk, Mark, and Delgado Bolton, Roberto C.

Subjects
*SQUAMOUS cell carcinoma, *SENTINEL lymph nodes, *NUCLEAR medicine, *LYMPH nodes, *CARCINOMA
Abstract

Purpose: Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node entails a sequence of procedures with participation of specialists in nuclear medicine, radiology, surgery, and pathology. The aim of this document is to provide guidelines for nuclear medicine physicians performing lymphoscintigraphy for sentinel lymph node detection in patients with early N0 oral cavity squamous cell carcinoma.Methods: These practice guidelines were written and have been approved by the European Association of Nuclear Medicine (EANM) and the International Atomic Energy Agency (IAEA) to promote high-quality lymphoscintigraphy. The final result has been discussed by distinguished experts from the EANM Oncology Committee, and national nuclear medicine societies. The document has been endorsed by the Society of Nuclear Medicine and Molecular Imaging (SNMMI).These guidelines, together with another two focused on Surgery and Pathology (and published in specialised journals), are part of the synergistic efforts developed in preparation for the "2018 Sentinel Node Biopsy in Head and Neck Consensus Conference".Conclusion: The present practice guidelines will help nuclear medicine practitioners play their essential role in providing high-quality lymphatic mapping for the care of early N0 oral cavity squamous cell carcinoma patients. [ABSTRACT FROM AUTHOR]

Published
2019
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215. Has the Time Come to Switch From Extensive Lymph Node Dissection to Sentinel Lymph Node Biopsy in Prostate Cancer Patients Treated With Radical Laparoscopic Prostatectomy?

Author

Delgado Bolton, Roberto C., Calapaquí Terán, Adriana K., and Giammarile, Francesco

Abstract

The efficacy of the available procedures currently recommended for staging and prognostic evaluation of prostate cancer patients treated with radical laparoscopic prostatectomy is discussed, taking into account the available evidence and potential implications in patient management.

Published
2024
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220. Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist

Author

Cacicedo, Jon, primary, Navarro, Arturo, additional, del Hoyo, Olga, additional, Gomez-Iturriaga, Alfonso, additional, Alongi, Filippo, additional, Medina, Jose A, additional, Elicin, Olgun, additional, Skanjeti, Andrea, additional, Giammarile, Francesco, additional, Bilbao, Pedro, additional, Casquero, Francisco, additional, de Bari, Berardino, additional, and Dal Pra, Alan, additional

Published
2016
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222. Sentinel Lymph Node Biopsy in Pelvic Tumors

Author

Maccauro, Marco, primary, Lorenzoni, Alice, additional, Crippa, Flavio, additional, Manca, Gianpiero, additional, Chondrogiannis, Sotirios, additional, Giammarile, Francesco, additional, Colletti, Patrick M., additional, Cook, Gary J., additional, and Rubello, Domenico, additional

Published
2016
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224. 18F-FDG PET/CT in the Initial Assessment and for Follow-up in Patients With Tuberculosis

Author

Stelzmueller, Ingrid, primary, Huber, Helmut, additional, Wunn, Rainer, additional, Hodolic, Marina, additional, Mandl, Michael, additional, Lamprecht, Bernd, additional, Schinko, Herwig, additional, Fellner, Franz, additional, Skanjeti, Andrea, additional, Giammarile, Francesco, additional, Colletti, Patrick M., additional, Rubello, Domenico, additional, and Gabriel, Michael, additional

Published
2016
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225. Sentinel Lymph Node Biopsy in Breast Cancer

Author

Manca, Gianpiero, primary, Rubello, Domenico, additional, Tardelli, Elisa, additional, Giammarile, Francesco, additional, Mazzarri, Sara, additional, Boni, Giuseppe, additional, Chondrogiannis, Sotirios, additional, Marzola, Maria Cristina, additional, Chiacchio, Serena, additional, Ghilli, Matteo, additional, Roncella, Manuela, additional, Volterrani, Duccio, additional, and Colletti, Patrick M., additional

Published
2016
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226. Results of a Prospective Multicenter International Atomic Energy Agency Sentinel Node Trial on the Value of SPECT/CT Over Planar Imaging in Various Malignancies

Author

Jimenez-Heffernan, Amelia, primary, Ellmann, Annare, additional, Sado, Heitor, additional, Huić, Dražen, additional, Bal, Chandrasekhar, additional, Parameswaran, Ramanathapuram, additional, Giammarile, Francesco, additional, Pruzzo, Rossana, additional, Kostadinova, Irena, additional, Vorster, Mariza, additional, Almeida, Paulo, additional, Santiago, Jonas, additional, Gambhir, Sanjay, additional, Sergieva, Sonya, additional, Calderon, Alvaro, additional, Young, Gabriela Oh, additional, Valdes-Olmos, Renato, additional, Zaknun, John, additional, Magboo, Vincent Peter, additional, and Pascual, Thomas N.B., additional

Published
2015
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229. Pulmonary artery sarcoma, a paradigm of orphan thoracic oncology

Author

Girard, Nicolas, Triby-Moreau, Caroline, Benabidallah, Samir, Tronc, François, Revel, Didier, Giammarile, Francesco, Cordier, Jean-François, Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)

Subjects
TUMEUR THORACIQUE, [SDV]Life Sciences [q-bio], EMBOLIE PULMONAIRE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009
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230. L'apport de la tomographie par émission de positons au FDG pour la radiothérapie : résultats de l'évaluation économique du Stic « TEP et radiothérapie »

Author

Remonnay, Raphaël, Morelle, Magali, Giammarile, Francesco, Pommier, Pascal, Carrère, Marie-Odile, Centre Léon Bérard [Lyon], Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)

Subjects
TEP, Cancer du poumon non à petites cellules, Évaluation économique, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Maladie de Hodgkin, STIC, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2009

232. Guideline for PET/CT imaging of neuroendocrine neoplasms with Ga-DOTA-conjugated somatostatin receptor targeting peptides and F-DOPA.

Author

Balogova, Sona, Beheshti, Mohsen, Bozkurt, Murat, Giammarile, Francesco, Virgolini, Irene, Decristoforo, Clemens, Rubello, Domenico, Ambrosini, Valentina, Fanti, Stefano, Kjaer, Andreas, Delgado-Bolton, Roberto, Kunikowska, Jolanta, Oyen, Wim, and Chiti, Arturo

Subjects
POSITRON emission tomography, SOMATOSTATIN receptors, PEPTIDES, TUMORS, PARAGANGLIOMA
Abstract

Purpose & Methods: Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline is aimed to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin receptor (SSTR) PET/CT imaging using Ga-DOTA-conjugated peptides, as well as F-DOPA imaging for various neuroendocrine neoplasms. Results & Conclusion: The previous procedural guideline by EANM regarding the use PET/CT tumour imaging with Ga-conjugated peptides has been revised and updated with the relevant and recent literature in the field with contribution of distinguished experts. [ABSTRACT FROM AUTHOR]

Published
2017
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239. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0

Author

Boellaard, Ronald, primary, Delgado-Bolton, Roberto, additional, Oyen, Wim J. G., additional, Giammarile, Francesco, additional, Tatsch, Klaus, additional, Eschner, Wolfgang, additional, Verzijlbergen, Fred J., additional, Barrington, Sally F., additional, Pike, Lucy C., additional, Weber, Wolfgang A., additional, Stroobants, Sigrid, additional, Delbeke, Dominique, additional, Donohoe, Kevin J., additional, Holbrook, Scott, additional, Graham, Michael M., additional, Testanera, Giorgio, additional, Hoekstra, Otto S., additional, Zijlstra, Josee, additional, Visser, Eric, additional, Hoekstra, Corneline J., additional, Pruim, Jan, additional, Willemsen, Antoon, additional, Arends, Bertjan, additional, Kotzerke, Jörg, additional, Bockisch, Andreas, additional, Beyer, Thomas, additional, Chiti, Arturo, additional, and Krause, Bernd J., additional

Published
2014
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243. Guidelines for Imaging and Staging of Neuroblastic Tumors: Consensus Report from the International Neuroblastoma Risk Group Project

Author

Brisse, Herve J., McCarville, M. Beth, Granata, Claudio, Krug, K. Barbara, Wootton-Gorges, Sandra L., Kanegawa, Kimio, Giammarile, Francesco, Schmidt, Matthias, Shulkin, Barry L., Matthay, Katherine K., Lewington, Valerie J., Sarnacki, Sabine, Hero, Barbara, Kaneko, Michio, London, Wendy B., Pearson, Andrew D. J., Cohn, Susan L., Monclair, Tom, Brisse, Herve J., McCarville, M. Beth, Granata, Claudio, Krug, K. Barbara, Wootton-Gorges, Sandra L., Kanegawa, Kimio, Giammarile, Francesco, Schmidt, Matthias, Shulkin, Barry L., Matthay, Katherine K., Lewington, Valerie J., Sarnacki, Sabine, Hero, Barbara, Kaneko, Michio, London, Wendy B., Pearson, Andrew D. J., Cohn, Susan L., and Monclair, Tom

Abstract

Neuroblastoma is an enigmatic disease entity; some tumors disappear spontaneously without any therapy, while others progress with a fatal outcome despite the implementation of maximal modern therapy. However, strong prognostic factors can accurately predict whether children have good or bad disease at diagnosis, and the clinical stage is currently the most significant and clinically relevant prognostic factor. Therefore, for an individual patient, proper staging is of paramount importance for risk assessment and selection of optimal treatment. In 2009, the International Neuroblastoma Risk Group (INRG) Project proposed a new staging system designed for tumor staging before any treatment, including surgery. Compared with the focus of the International Neuroblastoma Staging System, which is currently the most used, the focus has now shifted from surgicopathologic findings to imaging findings. The new INRG Staging System includes two stages of localized disease, which are dependent on whether image-defined risk factors (IDRFs) are or are not present. IDRFs are features detected with imaging at the time of diagnosis. The present consensus report was written by the INRG Imaging Committee to optimize imaging and staging and reduce interobserver variability. The rationales for using imaging methods (ultrasonography, magnetic resonance imaging, computed tomography, and scintigraphy), as well as technical guidelines, are described. Definitions of the terms recommended for assessing IDRFs are provided with examples. It is anticipated that the use of standardized nomenclature will contribute substantially to more uniform staging and thereby facilitate comparisons of clinical trials conducted in different parts of the world. (C) RSNA, 2011

Published
2011

246. F-FDG PET/CT quantification in head and neck squamous cell cancer: principles, technical issues and clinical applications.

Author

Manca, Gianpiero, Vanzi, Eleonora, Rubello, Domenico, Giammarile, Francesco, Grassetto, Gaia, Wong, Ka, Perkins, Alan, Colletti, Patrick, and Volterrani, Duccio

Subjects
HEAD & neck cancer diagnosis, SQUAMOUS cell carcinoma, POSITRON emission tomography, FLUORODEOXYGLUCOSE F18, QUANTITATIVE research, DIAGNOSIS
Abstract

F-FDG PET/CT plays a crucial role in the diagnosis and management of patients with head and neck squamous cell cancer (HNSCC). The major clinical applications of this method include diagnosing an unknown primary tumour, identifying regional lymph node involvement and distant metastases, and providing prognostic information. F-FDG PET/CT is also used for precise delineation of the tumour volume for radiation therapy planning and dose painting, and for treatment response monitoring, by detecting residual or recurrent disease. Most of these applications would benefit from a quantitative approach to the disease, but the quantitative capability of F-FDG PET/CT is still underused in HNSCC. Innovations in PET/CT technology promise to overcome the issues that until now have hindered the employment of dynamic procedures in clinical practice and have limited 'quantification' to the evaluation of standardized uptake values (SUV), de facto a semiquantitative parameter, the limits of which are well known to the nuclear medicine community. In this paper the principles of quantitative imaging and the related technical issues are reviewed so that professionals involved in HNSCC management can reflect on the advantages of 'true' quantification. A discussion is then presented on how semiquantitative information is currently used in clinical F-FDG PET/CT applications in HNSCC, by discussing the improvements that could be obtained with more advanced and 'personalized' quantification techniques. [ABSTRACT FROM AUTHOR]

Published
2016
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