Search

Your search keyword '"Griggs R"' showing total 687 results
Start Over Author "Griggs R"
687 results on '"Griggs R"'

204. Reporting clinical trials: Full access to all the data

Author

Rosenberg, R. N., Aminoff, M., Boller, F., Griggs, R. C., Hallett, M., Johnson, R. T., Kennard, C., Anthony Lang, Lees, A. J., Lisak, R., Newsom-Davis, J., Pedley, T. A., Selzer, M. E., and Zochodne, D.

232. Duchenne muscular dystrophy: Patterns of clinical progression and effects of supportive therapy

Author

Brooke, M. H., primary, Fenichel, G. M., additional, Griggs, R. C., additional, Mendell, J. R., additional, Moxley, R., additional, Florence, J., additional, King, W. M., additional, Pandya, S., additional, Robison, J., additional, Schierbecker, J., additional, Signore, L., additional, Miller, J. P., additional, Gilder, B. F., additional, Kaiser, K. K., additional, Mandel, S., additional, and Arfken, C., additional

Published
1989
Full Text
View/download PDF

247. Reporting clinical trials: full access to all the data.

Author

Rosenberg, R. N., Aminoff, M., Boller, F., Soerensen, P. S., Griggs, R. C., Hachinski, V., Hallett, M., Johnson, R. T., Kennard, C., Lang, A. E., Lees, A. J., Lisak, R., Newsom-Davis, J., Pedley, T. A., Selzer, M. E., and Zochodne, D.

Subjects
AUTHORSHIP, RESEARCH, MEDICAL research, PERIODICALS, DISCRIMINATION (Sociology), CORPORATE sponsorship
Abstract

This article recommends new policy for the submission of medical papers to publications regarding an author's disclosure of details of their own and their corporate sponsor's role in the study being submitted. This is due, the authors claim, to an increasing complexity in biomedical research because of the involvement of investors, universities, commercial research, and industry in funding research. Authors are already required to declare any conflicts of interest they may have and any financial interests they may have, which serve to alert the editors and readers to any potential bias.

Published
2002
Full Text
View/download PDF

248. Comparison of Standard Culture-Based Method to Culture-Independent Method for Evaluation of Hygiene Effects on the Hand Microbiome

Author

Zapka, C., Leff, J., Henley, J., Tittl, J., De Nardo, E., Butler, M., Griggs, R., Fierer, N., and Edmonds-Wilson, S.

Abstract

ABSTRACTHands play a critical role in the transmission of microbiota on one’s own body, between individuals, and on environmental surfaces. Effectively measuring the composition of the hand microbiome is important to hand hygiene science, which has implications for human health. Hand hygiene products are evaluated using standard culture-based methods, but standard test methods for culture-independent microbiome characterization are lacking. We sampled the hands of 50 participants using swab-based and glove-based methods prior to and following four hand hygiene treatments (using a nonantimicrobial hand wash, alcohol-based hand sanitizer [ABHS], a 70% ethanol solution, or tap water). We compared results among culture plate counts, 16S rRNA gene sequencing of DNA extracted directly from hands, and sequencing of DNA extracted from culture plates. Glove-based sampling yielded higher numbers of unique operational taxonomic units (OTUs) but had less diversity in bacterial community composition than swab-based sampling. We detected treatment-induced changes in diversity only by using swab-based samples (P< 0.001); we were unable to detect changes with glove-based samples. Bacterial cell counts significantly decreased with use of the ABHS (P< 0.05) and ethanol control (P< 0.05). Skin hydration at baseline correlated with bacterial abundances, bacterial community composition, pH, and redness across subjects. The importance of the method choice was substantial. These findings are important to ensure improvement of hand hygiene industry methods and for future hand microbiome studies. On the basis of our results and previously published studies, we propose recommendations for best practices in hand microbiome research.IMPORTANCEThe hand microbiome is a critical area of research for diverse fields, such as public health and forensics. The suitability of culture-independent methods for assessing effects of hygiene products on microbiota has not been demonstrated. This is the first controlled laboratory clinical hand study to have compared traditional hand hygiene test methods with newer culture-independent characterization methods typically used by skin microbiologists. This study resulted in recommendations for hand hygiene product testing, development of methods, and future hand skin microbiome research. It also demonstrated the importance of inclusion of skin physiological metadata in skin microbiome research, which is atypical for skin microbiome studies.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results