337 results on '"Gulizia, M"'
Search Results
202. Advancements in ‘Over-the-Wire' Versus Stylet-Guided Left Ventricular Leads
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Boveda, S. and Gulizia, M. M., editor
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- 2005
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203. Is CRT Useful in Patients with Atrial Fibrillation?
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Paperini, l., Carluccio, M., Pardini, E., and Gulizia, M. M., editor
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- 2005
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204. Assessment of Diastolic Function in Heart Failure and Atrial Fibrillation
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Carerj, S., Raffa, S., Zito, C., and Gulizia, M. M., editor
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- 2005
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205. How to Detect Dyssynchrony and How to Correct It
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Ascione, L., Accadia, M., Iengo, R., Rumolo, S.E., Muto, C., Canciello, M., Carreras, G., Tuccillo, B., and Gulizia, M. M., editor
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- 2005
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206. The Role of Imaging in Catheter Ablation of Atrial Fibrillation
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Kautzner, J., Peichl, P., Mlcochova, H., and Gulizia, M. M., editor
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- 2005
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207. Non-Electric Treatment of Atrial Fibrillation: When Not to Treat?
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Pedretti, R.F.E. and Gulizia, M. M., editor
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- 2005
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208. Guidelines for the Management of Patients with Heart Failure
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Sinagra, G., Sabbadini, G., Rakar, S., Perkan, A., Zecchin, M., Salvatore, L., Longaro, F., Di Lenarda, A., and Gulizia, M. M., editor
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- 2005
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209. Advances in Surgical Treatment of Atrial Fibrillation
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Patanè, L., Cavallaro, A., and Gulizia, M. M., editor
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- 2005
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210. Atypical Atrial Flutter
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Montenero, A.S. and Gulizia, M. M., editor
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- 2005
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211. Pharmacological Prevention of Arrhythmic Recurrences
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Chiaranda, G., Cavarra, M.L., Romeo, C.L., Chiaranda, M., Regolo, T., and Gulizia, M. M., editor
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- 2005
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212. Timing and Typology of Cardio-Embolic Prevention in Patients with Atrial Fibrillation
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Di Pasquale, G., Casella, G., Pavesi, P.C., and Gulizia, M. M., editor
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- 2005
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213. Role of Echocardiography in the Management of Atrial Fibrillation Patients
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Antonini-Canterin, F., Allocca, G., Rivaben, D., Korcova-Miertusova, R., Piazza, R., Brieda, M., Hrovatin, E., Dametto, E., Zardo, F., Nicolosi, G.L., and Gulizia, M. M., editor
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- 2005
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214. Aspirin and Cardiovascular Prevention in the Guidelines and in the Real World
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Di Pasquale, G., Pavesi, P.C., Casella, G., and Gulizia, M. M., editor
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- 2005
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215. New Approach in the Prevention of Atrial Fibrillation: Role of Angiotensin II Antagonists
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Verdecchia, P., Angeli, F., Sardone, M. G., Gattobigio, R., and Gulizia, M. M., editor
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- 2005
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216. Guidelines for Antihypertensive Treatment: The Debate on the Choice of Antihypertensive Drugs
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Salvetti, A., Ghiadoni, L., Salvetti, G., and Gulizia, M. M., editor
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- 2005
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217. Tirofiban and NSTE-ACS: The Current Perspective
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Cavallini, C. and Gulizia, M. M., editor
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- 2005
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218. Serial Changes in Left Ventricular Mass in Hypertension: Prognostic Impact
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Verdecchia, P., Angeli, F., Sardone, M.G., Gattobigio, R., and Gulizia, M. M., editor
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- 2005
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219. New Strategies for Treating Myocardial Infarctions
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Chiarella, F., Nicolino, A., Paonessa, K., Rossi, F., and Gulizia, M. M., editor
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- 2005
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220. Acute Coronary Syndromes and Diabetes: How Much Can We Intervene?
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Bovenzi, F., De Luca, L., Adorisio, R., and Gulizia, M. M., editor
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- 2005
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221. Spinal Cord Stimulation in Refractory Coronary Artery Disease: The Last Resort?
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Theres, H., Eddicks, S., Schenk, M., Maier-Hauff, K., Spies, C., Baumann, G., and Gulizia, M. M., editor
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- 2005
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222. Pathogenetic and Immunological Paradigm of Atherosclerotic Plaque
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Calcara, G., Corno, C., and Gulizia, M. M., editor
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- 2005
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223. Are a Single Measurement of Troponin-I and C-Reactive Protein of Clinical Significance in Patients with Acute Coronary Syndromes?
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Oltrona, L., Pirola, R., and Gulizia, M. M., editor
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- 2005
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224. Role of His-Bundle Pacing: Reliability and Potential to Avoid Ventricular Dyssynchrony
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Zanon, F., Baracca, E., Aggio, S., Boaretto, G., Pastore, G., Zonzin, P., and Gulizia, M. M., editor
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- 2005
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225. Trend of salt intake measured by 24-h urine collection in the Italian adult population between the 2008 and 2018 CUORE project surveys
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Roberto Iacone, Brigitta Buttari, Cinzia Lo Noce, Daniela Galeone, Serena Vannucchi, Simona Giampaoli, Michele Massimo Gulizia, Ornella Russo, Pasquale Strazzullo, Luigi Palmieri, Francesca Vespasiano, Paolo Bellisario, Graziano Onder, Daniela Minutoli, Ferruccio Galletti, Chiara Donfrancesco, Anna Di Lonardo, Elisabetta Profumo, Donfrancesco, C., Lo Noce, C., Russo, O., Minutoli, D., Di Lonardo, A., Profumo, E., Buttari, B., Iacone, R., Vespasiano, F., Vannucchi, S., Onder, G., Galletti, F., Galeone, D., Bellisario, P., Gulizia, M. M., Giampaoli, S., Palmieri, L., and Strazzullo, P.
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Population ,Adult population ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Urinalysis ,030204 cardiovascular system & hematology ,Recommended Dietary Allowances ,Diet Surveys ,Excretion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Sodium Chloride, Dietary ,Salt intake ,education ,Aged ,24 h urine ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Feeding Behavior ,Diet, Sodium-Restricted ,Middle Aged ,Non-communicable disease ,Diet ,Cross-Sectional Studies ,Italy ,Chronic Disease ,Female ,Christian ministry ,Diet, Healthy ,Cardiology and Cardiovascular Medicine ,business ,Risk Reduction Behavior ,Body mass index ,Demography - Abstract
Background and aims: The WHO Global Action Plan for the Prevention of non-communicable diseases (NCDs) recommends a 30% relative reduction in mean population salt/sodium intake. The study assessed the trend in the habitual salt intake of the Italian adult population from 2008 to 2012 to 2018–2019 based on 24-h urinary sodium excretion, in the framework of the CUORE Project/MINISAL-GIRCSI/MENO SALE PIU’ SALUTE national surveys. Methods and results: Data were from cross-sectional surveys of randomly selected age and sex–stratified samples of resident persons aged 35–74 years in 10 (out of 20) Italian Regions distributed in North, Centre and South of the Country. Urinary sodium and creatinine measurements were carried out in a central laboratory. The analyses included 942 men and 916 women examined in 2008–2012, and 967 men and 1010 women examined in 2018–2019. The age-standardized mean daily population salt (sodium chloride) intake was 10.8 g (95% CI 10.5–11.1) in men and 8.3 g (8.1–8.5) in women in 2008–2012 and respectively 9.5 g (9.3–9.8) and 7.2 g (7.0–7.4) in 2018–2019. A statistically significant (p
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- 2021
226. Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry
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George Ntaios, Menno V. Huisman, Hans-Christoph Diener, Jonathan L. Halperin, Christine Teutsch, Sabrina Marler, Venkatesh K. Gurusamy, Milla Thompson, Gregory Y.H. Lip, Brian Olshansky, Dzifa Wosornu Abban, Nasser Abdul, Atilio Marcelo Abud, Fran Adams, Srinivas Addala, Pedro Adragão, Walter Ageno, Rajesh Aggarwal, Sergio Agosti, Piergiuseppe Agostoni, Francisco Aguilar, Julio Aguilar Linares, Luis Aguinaga, Jameel Ahmed, Allessandro Aiello, Paul Ainsworth, Jorge Roberto Aiub, Raed Al-Dallow, Lisa Alderson, Jorge Antonio Aldrete Velasco, Dimitrios Alexopoulos, Fernando Alfonso Manterola, Pareed Aliyar, David Alonso, Fernando Augusto Alves da Costa, José Amado, Walid Amara, Mathieu Amelot, Nima Amjadi, Fabrizio Ammirati, Marianna Andrade, Nabil Andrawis, Giorgio Annoni, Gerardo Ansalone, M.Kevin Ariani, Juan Carlos Arias, Sébastien Armero, Chander Arora, Muhammad Shakil Aslam, M. Asselman, Philippe Audouin, Charles Augenbraun, S. Aydin, Ivaneta Ayryanova, Emad Aziz, Luciano Marcelo Backes, E. Badings, Ermentina Bagni, Seth H. Baker, Richard Bala, Antonio Baldi, Shigenobu Bando, Subhash Banerjee, Alan Bank, Gonzalo Barón Esquivias, Craig Barr, Maria Bartlett, Vanja Basic Kes, Giovanni Baula, Steffen Behrens, Alan Bell, Raffaella Benedetti, Juan Benezet Mazuecos, Bouziane Benhalima, Jutta Bergler-Klein, Jean-Baptiste Berneau, Richard A. Bernstein, Percy Berrospi, Sergio Berti, Andrea Berz, Elizabeth Best, Paulo Bettencourt, Robert Betzu, Ravi Bhagwat, Luna Bhatta, Francesco Biscione, Giovanni BISIGNANI, Toby Black, Michael J. Bloch, Stephen Bloom, Edwin Blumberg, Mario Bo, Ellen Bøhmer, Andreas Bollmann, Maria Grazia Bongiorni, Giuseppe Boriani, D.J. Boswijk, Jochen Bott, Edo Bottacchi, Marica Bracic Kalan, Drew Bradman, Donald Brautigam, Nicolas Breton, P.J.A.M. Brouwers, Kevin Browne, Jordi Bruguera Cortada, A. Bruni, Claude Brunschwig, Hervé Buathier, Aurélie Buhl, John Bullinga, Jose Walter Cabrera, Alberto Caccavo, Shanglang Cai, Sarah Caine, Leonardo Calò, Valeria Calvi, Mauricio Camarillo Sánchez, Rui Candeias, Vincenzo Capuano, Alessandro Capucci, Ronald Caputo, Tatiana Cárdenas Rizo, Francisco Cardona, Francisco Carlos da Costa Darrieux, Yan Carlos Duarte Vera, Antonio Carolei, Susana Carreño, Paula Carvalho, Susanna Cary, Gavino Casu, Claudio Cavallini, Guillaume Cayla, Aldo Celentano, Tae-Joon Cha, Kwang Soo Cha, Jei Keon Chae, Kathrine Chalamidas, Krishnan Challappa, Sunil Prakash Chand, Harinath Chandrashekar, Ludovic Chartier, Kausik Chatterjee, Carlos Antero Chavez Ayala, Aamir Cheema, Amjad Cheema, Lin Chen, Shih-Ann Chen, Jyh Hong Chen, Fu-Tien Chiang, Francesco Chiarella, Lin Chih-Chan, Yong Keun Cho, Jong-Il Choi, Dong Ju Choi, Guy Chouinard, Danny Hoi-Fan Chow, Dimitrios Chrysos, Galina Chumakova, Eduardo Julián José Roberto Chuquiure Valenzuela, Nicoleta Cindea Nica, David J. Cislowski, Anthony Clay, Piers Clifford, Andrew Cohen, Michael Cohen, Serge Cohen, Furio Colivicchi, Ronan Collins, Paolo Colonna, Steve Compton, Derek Connolly, Alberto Conti, Gabriel Contreras Buenostro, Gregg Coodley, Martin Cooper, Julian Coronel, Giovanni Corso, Juan Cosín Sales, Yves Cottin, John Covalesky, Aurel Cracan, Filippo Crea, Peter Crean, James Crenshaw, Tina Cullen, Harald Darius, Patrick Dary, Olivier Dascotte, Ira Dauber, Vicente Davalos, Ruth Davies, Gershan Davis, Jean-Marc Davy, Mark Dayer, Marzia De Biasio, Silvana De Bonis, Raffaele De Caterina, Teresiano De Franceschi, J.R. de Groot, José De Horta, Axel De La Briolle, Gilberto de la Pena Topete, Angelo Amato Vicenzo de Paola, Weimar de Souza, A. de Veer, Luc De Wolf, Eric Decoulx, Sasalu Deepak, Pascal Defaye, Freddy Del-Carpio Munoz, Diana Delic Brkljacic, N. Joseph Deumite, Silvia Di Legge, Igor Diemberger, Denise Dietz, Pedro Dionísio, Qiang Dong, Fabio Rossi dos Santos, Elena Dotcheva, Rami Doukky, Anthony D'Souza, Simon Dubrey, Xavier Ducrocq, Dmitry Dupljakov, Mauricio Duque, Dipankar Dutta, Nathalie Duvilla, A. Duygun, Rainer Dziewas, Charles B. Eaton, William Eaves, L.A. Ebels-Tuinbeek, Clifford Ehrlich, Sabine Eichinger-Hasenauer, Steven J. Eisenberg, Adnan El Jabali, Mahfouz El Shahawy, Mauro Esteves Hernandes, Ana Etxeberria Izal, Rudolph Evonich, Oksana Evseeva, Andrey Ezhov, Raed Fahmy, Quan Fang, Ramin Farsad, Laurent Fauchier, Stefano Favale, Maxime Fayard, Jose Luis Fedele, Francesco Fedele, Olga Fedorishina, Steven R. Fera, Luis Gustavo Gomes Ferreira, Jorge Ferreira, Claudio Ferri, Anna Ferrier, Hugo Ferro, Alexandra Finsen, Brian First, Stuart Fischer, Catarina Fonseca, Luísa Fonseca Almeida, Steven Forman, Brad Frandsen, William French, Keith Friedman, Athena Friese, Ana Gabriela Fruntelata, Shigeru Fujii, Stefano Fumagalli, Marta Fundamenski, Yutaka Furukawa, Matthias Gabelmann, Nashwa Gabra, Niels Gadsbøll, Michel Galinier, Anders Gammelgaard, Priya Ganeshkumar, Christopher Gans, Antonio Garcia Quintana, Olivier Gartenlaub, Achille Gaspardone, Conrad Genz, Frédéric Georger, Jean-Louis Georges, Steven Georgeson, Evaldas Giedrimas, Mariusz Gierba, Ignacio Gil Ortega, Eve Gillespie, Alberto Giniger, Michael C. Giudici, Alexandros Gkotsis, Taya V. Glotzer, Joachim Gmehling, Jacek Gniot, Peter Goethals, Seth Goldbarg, Ronald Goldberg, Britta Goldmann, Sergey Golitsyn, Silvia Gómez, Juan Gomez Mesa, Vicente Bertomeu Gonzalez, Jesus Antonio Gonzalez Hermosillo, Víctor Manuel González López, Hervé Gorka, Charles Gornick, Diana Gorog, Venkat Gottipaty, Pascal Goube, Ioannis Goudevenos, Brett Graham, G. Stephen Greer, Uwe Gremmler, Paul G. Grena, Martin Grond, Edoardo Gronda, Gerian Grönefeld, Xiang Gu, Ivett Guadalupe Torres Torres, Gabriele Guardigli, Carolina Guevara, Alexandre Guignier, Michele Gulizia, Michael Gumbley, Albrecht Günther, Andrew Ha, Georgios Hahalis, Joseph Hakas, Christian Hall, Bing Han, Seongwook Han, Joe Hargrove, David Hargroves, Kenneth B. Harris, Tetsuya Haruna, Emil Hayek, Jeff Healey, Steven Hearne, Michael Heffernan, Geir Heggelund, J.A. Heijmeriks, Maarten Hemels, I. Hendriks, Sam Henein, Sung-Ho Her, Paul Hermany, Jorge Eduardo Hernández Del Río, Yorihiko Higashino, Michael Hill, Tetsuo Hisadome, Eiji Hishida, Etienne Hoffer, Matthew Hoghton, Kui Hong, Suk keun Hong, Stevie Horbach, Masataka Horiuchi, Yinglong Hou, Jeff Hsing, Chi-Hung Huang, David Huckins, null kathy Hughes, A. Huizinga, E.L. Hulsman, Kuo-Chun Hung, Gyo-Seung Hwang, Margaret Ikpoh, Davide Imberti, Hüseyin Ince, Ciro Indolfi, Shujiro Inoue, Didier Irles, Harukazu Iseki, C. Noah Israel, Bruce Iteld, Venkat Iyer, Ewart Jackson-Voyzey, Naseem Jaffrani, Frank Jäger, Martin James, Sung-Won Jang, Nicolas Jaramillo, Nabil Jarmukli, Robert J. Jeanfreau, Ronald D. Jenkins, Carlos Jerjes Sánchez, Javier Jimenez, Robert Jobe, Tomas Joen-Jakobsen, Nicholas Jones, Jose Carlos Moura Jorge, Bernard Jouve, Byung Chun Jung, Kyung Tae Jung, Werner Jung, Mikhail Kachkovskiy, Krystallenia Kafkala, Larisa Kalinina, Bernd Kallmünzer, Farzan Kamali, Takehiro Kamo, Priit Kampus, Hisham Kashou, Andreas Kastrup, Apostolos Katsivas, Elizabeth Kaufman, Kazuya Kawai, Kenji Kawajiri, John F. Kazmierski, P. Keeling, José Francisco Kerr Saraiva, Galina Ketova, AJIT Singh Khaira, Aleksey Khripun, Doo-Il Kim, Young Hoon Kim, Nam Ho Kim, Dae Kyeong Kim, Jeong Su Kim, June Soo Kim, Ki Seok Kim, Jin bae Kim, Elena Kinova, Alexander Klein, James J. Kmetzo, G. Larsen Kneller, Aleksandar Knezevic, Su Mei Angela Koh, Shunichi Koide, Anastasios Kollias, J.A. Kooistra, Jay Koons, Martin Koschutnik, William J. Kostis, Dragan Kovacic, Jacek Kowalczyk, Natalya Koziolova, Peter Kraft, Johannes A. Kragten, Mori Krantz, Lars Krause, B.J. Krenning, F. Krikke, Z. Kromhout, Waldemar Krysiak, Priya Kumar, Thomas Kümler, Malte Kuniss, Jen-Yuan Kuo, Achim Küppers, Karla Kurrelmeyer, Choong Hwan Kwak, Bénédicte Laboulle, Arthur Labovitz, Wen Ter Lai, Andy Lam, Yat Yin Lam, Fernando Lanas Zanetti, Charles Landau, Giancarlo Landini, Estêvão Lanna Figueiredo, Torben Larsen, Karine Lavandier, Jessica LeBlanc, Moon Hyoung Lee, Chang-Hoon Lee, John Lehman, Ana Leitão, Nicolas Lellouche, Malgorzata Lelonek, Radoslaw Lenarczyk, T. Lenderink, Salvador León González, Peter Leong-Sit, Matthias Leschke, Nicolas Ley, Zhanquan Li, Xiaodong Li, Weihua Li, Xiaoming Li, Christhoh Lichy, Ira Lieber, Ramon Horacio Limon Rodriguez, Hailong Lin, Feng Liu, Hengliang Liu, Guillermo Llamas Esperon, Nassip Llerena Navarro, Eric Lo, Sergiy Lokshyn, Amador López, José Luís López-Sendón, Adalberto Menezes Lorga Filho, Richard S. Lorraine, Carlos Alberto Luengas, Robert Luke, Ming Luo, Steven Lupovitch, Philippe Lyrer, Changsheng Ma, Genshan Ma, Irene Madariaga, Koji Maeno, Dominique Magnin, Gustavo Maid, Sumeet K. Mainigi, Konstantinos Makaritsis, Rohit Malhotra, Rickey Manning, Athanasios Manolis, Helard Andres Manrique Hurtado, Ioannis Mantas, Fernando Manzur Jattin, Vicky Maqueda, Niccolo Marchionni, Francisco Marin Ortuno, Antonio Martín Santana, Jorge Martinez, Petra Maskova, Norberto Matadamas Hernandez, Katsuhiro Matsuda, Tillmann Maurer, Ciro Mauro, Erik May, Nolan Mayer, John McClure, Terry McCormack, William McGarity, Hugh McIntyre, Brent McLaurin, Feliz Alvaro Medina Palomino, Francesco Melandri, Hiroshi Meno, Dhananjai Menzies, Marco Mercader, Christian Meyer, Beat j. Meyer, Jacek Miarka, Frank Mibach, Dominik Michalski, Patrik Michel, Rami Mihail Chreih, Ghiath Mikdadi, Milan Mikus, Davor Milicic, Constantin Militaru, Sedi Minaie, Bogdan Minescu, Iveta Mintale, Tristan Mirault, Michael J. Mirro, Dinesh Mistry, Nicoleta Violeta Miu, Naomasa Miyamoto, Tiziano Moccetti, Akber Mohammed, Azlisham Mohd Nor, Michael Mollerus, Giulio Molon, Sergio Mondillo, Patrícia Moniz, Lluis Mont, Vicente Montagud, Oscar Montaña, Cristina Monti, Luciano Moretti, Kiyoo Mori, Andrew Moriarty, Jacek Morka, Luigi Moschini, Nikitas Moschos, Andreas Mügge, Thomas J. Mulhearn, Carmen Muresan, Michela Muriago, Wlodzimierz Musial, Carl W. Musser, Francesco Musumeci, Thuraia Nageh, Hidemitsu Nakagawa, Yuichiro Nakamura, Toru Nakayama, Gi-Byoung Nam, Michele Nanna, Indira Natarajan, Hemal M. Nayak, Stefan Naydenov, Jurica Nazli, Alexandru Cristian Nechita, Libor Nechvatal, Sandra Adela Negron, James Neiman, Fernando Carvalho Neuenschwander, David Neves, Anna Neykova, Ricardo Nicolás Miguel, George Nijmeh, Alexey Nizov, Rodrigo Noronha Campos, Janko Nossan, Tatiana Novikova, Ewa Nowalany-Kozielska, Emmanuel Nsah, Juan Carlos Nunez Fragoso, Svetlana Nurgalieva, Dieter Nuyens, Ole Nyvad, Manuel Odin de Los Rios Ibarra, Philip O'Donnell, Martin O'Donnell, Seil Oh, Yong Seog Oh, Dongjin Oh, Gilles O'Hara, Kostas Oikonomou, Claudia Olivares, Richard Oliver, Rafael Olvera Ruiz, Christoforos Olympios, null Anna omaszuk-Kazberuk, Joaquín Osca Asensi, null eena Padayattil jose, Francisco Gerardo Padilla Padilla, Victoria Padilla Rios, Giuseppe Pajes, A. Shekhar Pandey, Gaetano Paparella, F. Paris, Hyung Wook Park, Jong Sung Park, Fragkiskos Parthenakis, Enrico Passamonti, Rajesh J. Patel, Jaydutt Patel, Mehool Patel, Janice Patrick, Ricardo Pavón Jimenez, Analía Paz, Vittorio Pengo, William Pentz, Beatriz Pérez, Alma Minerva Pérez Ríos, Alejandro Pérez-Cabezas, Richard Perlman, Viktor Persic, Francesco Perticone, Terri K. Peters, Sanjiv Petkar, Luis Felipe Pezo, Christian Pflücke, David N. Pham, Roland T. Phillips, Stephen Phlaum, Denis Pieters, Julien Pineau, Arnold Pinter, Fausto Pinto, R. Pisters, Nediljko Pivac, Darko Pocanic, Cristian Podoleanu, Alessandro Politano, Zdravka Poljakovic, Stewart Pollock, Jose Polo Garcéa, Holger Poppert, Maurizio Porcu, Antonio Pose Reino, Neeraj Prasad, Dalton Bertolim Précoma, Alessandro Prelle, John Prodafikas, Konstantin Protasov, Maurice Pye, Zhaohui Qiu, Jean-Michel Quedillac, Dimitar Raev, Carlos Antonio Raffo Grado, Sidiqullah Rahimi, Arturo Raisaro, Bhola Rama, Ricardo Ramos, Maria Ranieri, Nuno Raposo, Eric Rashba, Ursula Rauch-Kroehnert, Ramakota Reddy, Giulia Renda, Shabbir Reza, Luigi Ria, Dimitrios Richter, Hans Rickli, Werner Rieker, Tomas Ripolil Vera, Luiz Eduardo Ritt, Douglas Roberts, Ignacio Rodriguez Briones, Aldo Edwin Rodriguez Escudero, Carlos Rodríguez Pascual, Mark Roman, Francesco Romeo, E. Ronner, Jean-Francois Roux, Nadezda Rozkova, Miroslav Rubacek, Frank Rubalcava, Andrea M. Russo, Matthieu Pierre Rutgers, Karin Rybak, Samir Said, Tamotsu Sakamoto, Abraham Salacata, Adrien Salem, Rafael Salguero Bodes, Marco A. Saltzman, Alessandro Salvioni, Gregorio Sanchez Vallejo, Marcelo Sanmartín Fernández, Wladmir Faustino Saporito, Kesari Sarikonda, Taishi Sasaoka, Hamdi Sati, Irina Savelieva, Pierre-Jean Scala, Peter Schellinger, Carlos Scherr, Lisa Schmitz, Karl-Heinz Schmitz, Bettina Schmitz, Teresa Schnabel, Steffen Schnupp, Peter Schoeniger, Norbert Schön, Peter Schwimmbeck, Clare Seamark, Greg Searles, Karl-Heinz Seidl, Barry Seidman, Jaroslaw Sek, Lakshmanan Sekaran, Carlo SERRATI, Neerav Shah, Vinay Shah, Anil Shah, Shujahat Shah, Vijay Kumar Sharma, Louise Shaw, Khalid H. Sheikh, Naruhito Shimizu, Hideki Shimomura, Dong-Gu Shin, Eun-Seok Shin, Junya Shite, Gerolamo Sibilio, Frank Silver, Iveta Sime, Tim A. Simmers, Narendra Singh, Peter Siostrzonek, Didier Smadja, David W. Smith, Marcelo Snitman, Dario Sobral Filho, Hassan Soda, Carl Sofley, Adam Sokal, Yannie Soo Oi Yan, Rodolfo Sotolongo, Olga Ferreira de Souza, Jon Arne Sparby, Jindrich Spinar, David Sprigings, Alex C. Spyropoulos, Dimitrios Stakos, Clemens Steinwender, George Stergiou, Ian Stiell, Marcus Stoddard, Anastas Stoikov, Witold Streb, Ioannis Styliadis, Guohai Su, Xi Su, Wanda Sudnik, Kai Sukles, Xiaofei Sun, H. Swart, Janko Szavits-Nossan, Jens Taggeselle, Yuichiro Takagi, Amrit Pal Singh Takhar, Angelika Tamm, Katsumi Tanaka, Tanyanan Tanawuttiwat, Sherman Tang, Aylmer Tang, Giovanni Tarsi, Tiziana Tassinari, Ashis Tayal, Muzahir Tayebjee, J.M. ten Berg, Dan Tesloianu, Salem H.K. The, Dierk Thomas, Serge Timsit, Tetsuya Tobaru, Andrzej R. Tomasik, Mikhail Torosoff, Emmanuel Touze, Elina Trendafilova, W. Kevin Tsai, Hung Fat Tse, Hiroshi Tsutsui, Tian Ming Tu, Ype Tuininga, Minang Turakhia, Samir Turk, Wayne Tcurner, Arnljot Tveit, Richard Tytus, C. Valadão, P.F.M.M. van Bergen, Philippe van de Borne, B.J. van den Berg, C. van der Zwaan, M. Van Eck, Peter Vanacker, Dimo Vasilev, Vasileios Vasilikos, Maxim Vasilyev, Srikar Veerareddy, Mario Vega Miño, Asok Venkataraman, Paolo Verdecchia, Francesco Versaci, Ernst Günter Vester, Hubert Vial, Jason Victory, Alejandro Villamil, Marc Vincent, Anthony Vlastaris, Jürgen vom Dahl, Kishor Vora, Robert B. Vranian, Paul Wakefield, Ningfu Wang, Mingsheng Wang, Xinhua Wang, Feng Wang, Tian Wang, Alberta L. Warner, Kouki Watanabe, Jeanne Wei, Christian Weimar, Stanislav Weiner, Renate Weinrich, Ming-Shien Wen, Marcus Wiemer, Preben Wiggers, Andreas Wilke, David Williams, Marcus L. Williams, Bernhard Witzenbichler, Brian Wong, Ka Sing Lawrence Wong, Beata Wozakowska-Kaplon, Shulin Wu, Richard C. Wu, Silke Wunderlich, Nell Wyatt, John (Jack) Wylie, Yong Xu, Xiangdong Xu, Hiroki Yamanoue, Takeshi Yamashita, Ping Yen Bryan Yan, Tianlun Yang, Jing Yao, Kuo-Ho Yeh, Wei Hsian Yin, Yoto Yotov, Ralf Zahn, Stuart Zarich, Sergei Zenin, Elisabeth Louise Zeuthen, Huanyi Zhang, Donghui Zhang, Xingwei Zhang, Ping Zhang, Jun Zhang, Shui Ping Zhao, Yujie Zhao, Zhichen Zhao, Yang Zheng, Jing Zhou, Sergio Zimmermann, Andrea Zini, Steven Zizzo, Wenxia Zong, L Steven Zukerman, Cardiology, ACS - Heart failure & arrhythmias, Ntaios G., Huisman M.V., Diener H.-C., Halperin J.L., Teutsch C., Marler S., Gurusamy V.K., Thompson M., Lip G.Y.H., Olshansky B., Abban D.W., Abdul N., Abud A.M., Adams F., Addala S., Adragao P., Ageno W., Aggarwal R., Agosti S., Agostoni P., Aguilar F., Linares J.A., Aguinaga L., Ahmed J., Aiello A., Ainsworth P., Aiub J.R., Al-Dallow R., Alderson L., Aldrete Velasco J.A., Alexopoulos D., Manterola F.A., Aliyar P., Alonso D., Alves da Costa F.A., Amado J., Amara W., Amelot M., Amjadi N., Ammirati F., Andrade M., Andrawis N., Annoni G., Ansalone G., Ariani M.K., Arias J.C., Armero S., Arora C., Aslam M.S., Asselman M., Audouin P., Augenbraun C., Aydin S., Ayryanova I., Aziz E., Backes L.M., Badings E., Bagni E., Baker S.H., Bala R., Baldi A., Bando S., Banerjee S., Bank A., Esquivias G.B., Barr C., Bartlett M., Kes V.B., Baula G., Behrens S., Bell A., Benedetti R., Mazuecos J.B., Benhalima B., Bergler-Klein J., Berneau J.-B., Bernstein R.A., Berrospi P., Berti S., Berz A., Best E., Bettencourt P., Betzu R., Bhagwat R., Bhatta L., Biscione F., BISIGNANI G., Black T., Bloch M.J., Bloom S., Blumberg E., Bo M., Bohmer E., Bollmann A., Bongiorni M.G., Boriani G., Boswijk D.J., Bott J., Bottacchi E., Kalan M.B., Bradman D., Brautigam D., Breton N., Brouwers P.J.A.M., Browne K., Cortada J.B., Bruni A., Brunschwig C., Buathier H., Buhl A., Bullinga J., Cabrera J.W., Caccavo A., Cai S., Caine S., Calo L., Calvi V., Sanchez M.C., Candeias R., Capuano V., Capucci A., Caputo R., Rizo T.C., Cardona F., Carlos da Costa Darrieux F., Duarte Vera Y.C., Carolei A., Carreno S., Carvalho P., Cary S., Casu G., Cavallini C., Cayla G., Celentano A., Cha T.-J., Cha K.S., Chae J.K., Chalamidas K., Challappa K., Chand S.P., Chandrashekar H., Chartier L., Chatterjee K., Chavez Ayala C.A., Cheema A., Chen L., Chen S.-A., Chen J.H., Chiang F.-T., Chiarella F., Chih-Chan L., Cho Y.K., Choi J.-I., Choi D.J., Chouinard G., Hoi-Fan Chow D., Chrysos D., Chumakova G., Jose Roberto Chuquiure Valenzuela E.J., Nica N.C., Cislowski D.J., Clay A., Clifford P., Cohen A., Cohen M., Cohen S., Colivicchi F., Collins R., Colonna P., Compton S., Connolly D., Conti A., Buenostro G.C., Coodley G., Cooper M., Coronel J., Corso G., Sales J.C., Cottin Y., Covalesky J., Cracan A., Crea F., Crean P., Crenshaw J., Cullen T., Darius H., Dary P., Dascotte O., Dauber I., Davalos V., Davies R., Davis G., Davy J.-M., Dayer M., De Biasio M., De Bonis S., De Caterina R., De Franceschi T., de Groot J.R., De Horta J., De La Briolle A., Topete G.D.L.P., Vicenzo de Paola A.A., de Souza W., de Veer A., De Wolf L., Decoulx E., Deepak S., Defaye P., Del-Carpio Munoz F., Brkljacic D.D., Deumite N.J., Di Legge S., Diemberger I., Dietz D., Dionisio P., Dong Q., Rossi dos Santos F., Dotcheva E., Doukky R., D'Souza A., Dubrey S., Ducrocq X., Dupljakov D., Duque M., Dutta D., Duvilla N., Duygun A., Dziewas R., Eaton C.B., Eaves W., Ebels-Tuinbeek L.A., Ehrlich C., Eichinger-Hasenauer S., Eisenberg S.J., El Jabali A., El Shahawy M., Hernandes M.E., Izal A.E., Evonich R., Evseeva O., Ezhov A., Fahmy R., Fang Q., Farsad R., Fauchier L., Favale S., Fayard M., Fedele J.L., Fedele F., Fedorishina O., Fera S.R., Gomes Ferreira L.G., Ferreira J., Ferri C., Ferrier A., Ferro H., Finsen A., First B., Fischer S., Fonseca C., Almeida L.F., Forman S., Frandsen B., French W., Friedman K., Friese A., Fruntelata A.G., Fujii S., Fumagalli S., Fundamenski M., Furukawa Y., Gabelmann M., Gabra N., Gadsboll N., Galinier M., Gammelgaard A., Ganeshkumar P., Gans C., Quintana A.G., Gartenlaub O., Gaspardone A., Genz C., Georger F., Georges J.-L., Georgeson S., Giedrimas E., Gierba M., Ortega I.G., Gillespie E., Giniger A., Giudici M.C., Gkotsis A., Glotzer T.V., Gmehling J., Gniot J., Goethals P., Goldbarg S., Goldberg R., Goldmann B., Golitsyn S., Gomez S., Mesa J.G., Gonzalez V.B., Gonzalez Hermosillo J.A., Gonzalez Lopez V.M., Gorka H., Gornick C., Gorog D., Gottipaty V., Goube P., Goudevenos I., Graham B., Greer G.S., Gremmler U., Grena P.G., Grond M., Gronda E., Gronefeld G., Gu X., Torres Torres I.G., Guardigli G., Guevara C., Guignier A., Gulizia M., Gumbley M., Gunther A., Ha A., Hahalis G., Hakas J., Hall C., Han B., Han S., Hargrove J., Hargroves D., Harris K.B., Haruna T., Hayek E., Healey J., Hearne S., Heffernan M., Heggelund G., Heijmeriks J.A., Hemels M., Hendriks I., Henein S., Her S.-H., Hermany P., Hernandez Del Rio J.E., Higashino Y., Hill M., Hisadome T., Hishida E., Hoffer E., Hoghton M., Hong K., Hong S.K., Horbach S., Horiuchi M., Hou Y., Hsing J., Huang C.-H., Huckins D., kathy Hughe, Huizinga A., Hulsman E.L., Hung K.-C., Hwang G.-S., Ikpoh M., Imberti D., Ince H., Indolfi C., Inoue S., Irles D., Iseki H., Israel C.N., Iteld B., Iyer V., Jackson-Voyzey E., Jaffrani N., Jager F., James M., Jang S.-W., Jaramillo N., Jarmukli N., Jeanfreau R.J., Jenkins R.D., Sanchez C.J., Jimenez J., Jobe R., Joen-Jakobsen T., Jones N., Moura Jorge J.C., Jouve B., Jung B.C., Jung K.T., Jung W., Kachkovskiy M., Kafkala K., Kalinina L., Kallmunzer B., Kamali F., Kamo T., Kampus P., Kashou H., Kastrup A., Katsivas A., Kaufman E., Kawai K., Kawajiri K., Kazmierski J.F., Keeling P., Kerr Saraiva J.F., Ketova G., Khaira A.S., Khripun A., Kim D.-I., Kim Y.H., Kim N.H., Kim D.K., Kim J.S., Kim K.S., Kim J.B., Kinova E., Klein A., Kmetzo J.J., Kneller G.L., Knezevic A., Angela Koh S.M., Koide S., Kollias A., Kooistra J.A., Koons J., Koschutnik M., Kostis W.J., Kovacic D., Kowalczyk J., Koziolova N., Kraft P., Kragten J.A., Krantz M., Krause L., Krenning B.J., Krikke F., Kromhout Z., Krysiak W., Kumar P., Kumler T., Kuniss M., Kuo J.-Y., Kuppers A., Kurrelmeyer K., Kwak C.H., Laboulle B., Labovitz A., Lai W.T., Lam A., Lam Y.Y., Zanetti F.L., Landau C., Landini G., Figueiredo E.L., Larsen T., Lavandier K., LeBlanc J., Lee M.H., Lee C.-H., Lehman J., Leitao A., Lellouche N., Lelonek M., Lenarczyk R., Lenderink T., Gonzalez S.L., Leong-Sit P., Leschke M., Ley N., Li Z., Li X., Li W., Lichy C., Lieber I., Limon Rodriguez R.H., Lin H., Liu F., Liu H., Esperon G.L., Navarro N.L., Lo E., Lokshyn S., Lopez A., Lopez-Sendon J.L., Lorga Filho A.M., Lorraine R.S., Luengas C.A., Luke R., Luo M., Lupovitch S., Lyrer P., Ma C., Ma G., Madariaga I., Maeno K., Magnin D., Maid G., Mainigi S.K., Makaritsis K., Malhotra R., Manning R., Manolis A., Manrique Hurtado H.A., Mantas I., Jattin F.M., Maqueda V., Marchionni N., Ortuno F.M., Santana A.M., Martinez J., Maskova P., Hernandez N.M., Matsuda K., Maurer T., Mauro C., May E., Mayer N., McClure J., McCormack T., McGarity W., McIntyre H., McLaurin B., Medina Palomino F.A., Melandri F., Meno H., Menzies D., Mercader M., Meyer C., Meyer B.J., Miarka J., Mibach F., Michalski D., Michel P., Chreih R.M., Mikdadi G., Mikus M., Milicic D., Militaru C., Minaie S., Minescu B., Mintale I., Mirault T., Mirro M.J., Mistry D., Miu N.V., Miyamoto N., Moccetti T., Mohammed A., Nor A.M., Mollerus M., Molon G., Mondillo S., Moniz P., Mont L., Montagud V., Montana O., Monti C., Moretti L., Mori K., Moriarty A., Morka J., Moschini L., Moschos N., Mugge A., Mulhearn T.J., Muresan C., Muriago M., Musial W., Musser C.W., Musumeci F., Nageh T., Nakagawa H., Nakamura Y., Nakayama T., Nam G.-B., Nanna M., Natarajan I., Nayak H.M., Naydenov S., Nazli J., Nechita A.C., Nechvatal L., Negron S.A., Neiman J., Neuenschwander F.C., Neves D., Neykova A., Miguel R.N., Nijmeh G., Nizov A., Campos R.N., Nossan J., Novikova T., Nowalany-Kozielska E., Nsah E., Nunez Fragoso J.C., Nurgalieva S., Nuyens D., Nyvad O., Odin de Los Rios Ibarra M., O'Donnell P., O'Donnell M., Oh S., Oh Y.S., Oh D., O'Hara G., Oikonomou K., Olivares C., Oliver R., Ruiz R.O., Olympios C., Anna omaszuk-Kazberuk, Asensi J.O., eena Padayattil jose, Padilla Padilla F.G., Rios V.P., Pajes G., Pandey A.S., Paparella G., Paris F., Park H.W., Park J.S., Parthenakis F., Passamonti E., Patel R.J., Patel J., Patel M., Patrick J., Jimenez R.P., Paz A., Pengo V., Pentz W., Perez B., Perez Rios A.M., Perez-Cabezas A., Perlman R., Persic V., Perticone F., Peters T.K., Petkar S., Pezo L.F., Pflucke C., Pham D.N., Phillips R.T., Phlaum S., Pieters D., Pineau J., Pinter A., Pinto F., Pisters R., Pivac N., Pocanic D., Podoleanu C., Politano A., Poljakovic Z., Pollock S., Garcea J.P., Poppert H., Porcu M., Reino A.P., Prasad N., Precoma D.B., Prelle A., Prodafikas J., Protasov K., Pye M., Qiu Z., Quedillac J.-M., Raev D., Raffo Grado C.A., Rahimi S., Raisaro A., Rama B., Ramos R., Ranieri M., Raposo N., Rashba E., Rauch-Kroehnert U., Reddy R., Renda G., Reza S., Ria L., Richter D., Rickli H., Rieker W., Vera T.R., Ritt L.E., Roberts D., Briones I.R., Rodriguez Escudero A.E., Pascual C.R., Roman M., Romeo F., Ronner E., Roux J.-F., Rozkova N., Rubacek M., Rubalcava F., Russo A.M., Rutgers M.P., Rybak K., Said S., Sakamoto T., Salacata A., Salem A., Bodes R.S., Saltzman M.A., Salvioni A., Vallejo G.S., Fernandez M.S., Saporito W.F., Sarikonda K., Sasaoka T., Sati H., Savelieva I., Scala P.-J., Schellinger P., Scherr C., Schmitz L., Schmitz K.-H., Schmitz B., Schnabel T., Schnupp S., Schoeniger P., Schon N., Schwimmbeck P., Seamark C., Searles G., Seidl K.-H., Seidman B., Sek J., Sekaran L., SERRATI C., Shah N., Shah V., Shah A., Shah S., Sharma V.K., Shaw L., Sheikh K.H., Shimizu N., Shimomura H., Shin D.-G., Shin E.-S., Shite J., Sibilio G., Silver F., Sime I., Simmers T.A., Singh N., Siostrzonek P., Smadja D., Smith D.W., Snitman M., Filho D.S., Soda H., Sofley C., Sokal A., Oi Yan Y.S., Sotolongo R., Ferreira de Souza O., Sparby J.A., Spinar J., Sprigings D., Spyropoulos A.C., Stakos D., Steinwender C., Stergiou G., Stiell I., Stoddard M., Stoikov A., Streb W., Styliadis I., Su G., Su X., Sudnik W., Sukles K., Sun X., Swart H., Szavits-Nossan J., Taggeselle J., Takagi Y., Singh Takhar A.P., Tamm A., Tanaka K., Tanawuttiwat T., Tang S., Tang A., Tarsi G., Tassinari T., Tayal A., Tayebjee M., Berg J.M.T., Tesloianu D., The S.H.K., Thomas D., Timsit S., Tobaru T., Tomasik A.R., Torosoff M., Touze E., Trendafilova E., Tsai W.K., Tse H.F., Tsutsui H., Tu T.M., Tuininga Y., Turakhia M., Turk S., Tcurner W., Tveit A., Tytus R., Valadao C., van Bergen P.F.M.M., van de Borne P., van den Berg B.J., van der Zwaan C., Van Eck M., Vanacker P., Vasilev D., Vasilikos V., Vasilyev M., Veerareddy S., Mino M.V., Venkataraman A., Verdecchia P., Versaci F., Vester E.G., Vial H., Victory J., Villamil A., Vincent M., Vlastaris A., Dahl J.V., Vora K., Vranian R.B., Wakefield P., Wang N., Wang M., Wang X., Wang F., Wang T., Warner A.L., Watanabe K., Wei J., Weimar C., Weiner S., Weinrich R., Wen M.-S., Wiemer M., Wiggers P., Wilke A., Williams D., Williams M.L., Witzenbichler B., Wong B., Lawrence Wong K.S., Wozakowska-Kaplon B., Wu S., Wu R.C., Wunderlich S., Wyatt N., Wylie J.J., Xu Y., Xu X., Yamanoue H., Yamashita T., Bryan Yan P.Y., Yang T., Yao J., Yeh K.-H., Yin W.H., Yotov Y., Zahn R., Zarich S., Zenin S., Zeuthen E.L., Zhang H., Zhang D., Zhang X., Zhang P., Zhang J., Zhao S.P., Zhao Y., Zhao Z., Zheng Y., Zhou J., Zimmermann S., Zini A., Zizzo S., Zong W., and Zukerman L.S.
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Oral ,medicine.medical_specialty ,anticoagulants ,Vitamin K ,medicine.drug_class ,Medizin ,Administration, Oral ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,Antithrombotic treatment ,0302 clinical medicine ,Randomized controlled trial ,law ,Risk Factors ,Internal medicine ,Antithrombotic ,medicine ,non-vitamin-K antagonist oral anticoagulant ,Diseases of the circulatory (Cardiovascular) system ,Humans ,SAMe-TT2R2 ,In patient ,atrial fibrillation ,030212 general & internal medicine ,Prospective Studies ,Registries ,Medical prescription ,business.industry ,Anticoagulant ,non-vitamin-K antagonist oral ,Atrial fibrillation ,medicine.disease ,non-vitamin-K antagonist oral anticoagulants ,Clinical trial ,Stroke ,Treatment Outcome ,SAMe-TT ,RC666-701 ,2 ,R ,vitamin-K-antagonist oral anticoagulants ,Administration ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,SAMe-TT R ,Cardiology and Cardiovascular Medicine ,business - Abstract
CA extern - Weitere Nicht-UDE-Autoren sind nicht genannt. Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007. © 2020 Hellenic Society of Cardiology
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- 2021
227. Update on Management of Cardiovascular Diseases in Women
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Fabiana Lucà, Maurizio Giuseppe Abrignani, Iris Parrini, Stefania Angela Di Fusco, Simona Giubilato, Carmelo Massimiliano Rao, Laura Piccioni, Laura Cipolletta, Bruno Passaretti, Francesco Giallauria, Angelo Leone, Giuseppina Maura Francese, Carmine Riccio, Sandro Gelsomino, Furio Colivicchi, Michele Massimo Gulizia, Luca, F., Abrignani, M. G., Parrini, I., Di Fusco, S. A., Giubilato, S., Rao, C. M., Piccioni, L., Cipolletta, L., Passaretti, B., Giallauria, F., Leone, A., Francese, G. M., Riccio, C., Gelsomino, S., Colivicchi, F., and Gulizia, M. M.
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SEX-BASED DIFFERENCES ,cardiovascular risk factors ,GENDER-DIFFERENCES ,IRON-DEFICIENCY ANEMIA ,General Medicine ,POLYCYSTIC-OVARY-SYNDROME ,2021 ESC GUIDELINES ,Cardiovascular risk factor ,ESTROGEN PLUS PROGESTIN ,MYOCARDIAL-INFARCTION ,cardiovascular disease ,ESC WORKING GROUP ,gender ,CORONARY-HEART-DISEASE ,women ,PRIMARY PREVENTION ,RISK-FACTOR CONTROL - Abstract
Cardiovascular diseases (CVD) have a lower prevalence in women than men; although, a higher mortality rate and a poorer prognosis are more common in women. However, there is a misperception of CVD female risk since women have commonly been considered more protected so that the real threat is vastly underestimated. Consequently, female patients are more likely to be treated less aggressively, and a lower rate of diagnostic and interventional procedures is performed in women than in men. In addition, there are substantial sex differences in CVD, so different strategies are needed. This review aims to evaluate the main gender-specific approaches in CVD.
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- 2022
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228. Consensus Document of the Italian Association of Hospital Cardiologists (ANMCO), Italian Society of Pediatric Cardiology (SICP), and Italian Society of Gynaecologists and Obstetrics (SIGO): pregnancy and congenital heart diseases
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Elsa Viora, Giovanna Geraci, Silvia Favilli, Massimo Chessa, Maria Giovanna Russo, Marco Bonvicini, Sebastiano Bianca, Marco Poli, Giuseppe Canzone, Gabriele Egidy Assenza, Rachele Adorisio, Maria Gabriella Carmina, Maurizio Mongiovì, Gabriella Agnoletti, Marcello Campisi, Chiara Barone, Berardo Sarubbi, Francesca Comoglio, Annalisa Alaimo, Innocenzo Bianca, Michele Massimo Gulizia, Bianca, I., Geraci, G., Gulizia, M. M., Assenza, G. E., Barone, C., Campisi, M., Alaimo, A., Adorisio, R., Comoglio, F., Favilli, S., Agnoletti, G., Carmina, M. G., Chessa, M., Sarubbi, B., Mongiovi, M., Russo, M. G., Bianca, S., Canzone, G., Bonvicini, M., Viora, E., and Poli, M.
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medicine.medical_specialty ,Pediatrics ,Heart disease ,Population ,Reproductive age ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Obstetrics and gynaecology ,Pregnancy ,medicine ,030212 general & internal medicine ,education ,Cardiac complication ,Congenital heart disease ,Risk assessment ,education.field_of_study ,business.industry ,Articles ,Cardiovascular disease ,medicine.disease ,Cardiac surgery ,Family medicine ,Cardiac complications ,Cardiology and Cardiovascular Medicine ,business ,Delivery ,Pediatric cardiology - Abstract
The success of cardiac surgery over the past 50 years has increased numbers and median age of survivors with congenital heart disease (CHD). Adults now represent two-thirds of patients with CHD; in the USA alone the number is estimated to exceed 1 million. In this population, many affected women reach reproductive age and wish to have children. While in many CHD patients pregnancy can be accomplished successfully, some special situations with complex anatomy, iatrogenic or residual pathology are associated with an increased risk of severe maternal and fetal complications. Pre-conception counselling allows women to come to truly informed choices. Risk stratification tools can also help high-risk women to eventually renounce to pregnancy and to adopt safe contraception options. Once pregnant, women identified as intermediate or high risk should receive multidisciplinary care involving a cardiologist, an obstetrician and an anesthesiologist with specific expertise in managing this peculiar medical challenge. This document is intended to provide cardiologists working in hospitals where an Obstetrics and Gynecology Department is available with a streamlined and practical tool, useful for them to select the best management strategies to deal with a woman affected by CHD who desires to plan pregnancy or is already pregnant.
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- 2017
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229. ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Joint Consensus Document on cholesterol and cardiovascular risk: diagnostic–therapeutic pathway in Italy
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Claudio Cricelli, Roberto Ferrari, Marino Scherillo, Gerardo Medea, Alberico L. Catapano, Giovanni Battista Zito, Mauro Campanini, Maurizio Averna, Simona Giampaoli, Andrea Di Lenarda, Francesco Rossi, Giuseppe Musumeci, Pompilio Faggiano, Attilio Maseri, Leonardo Bolognese, Enzo Bonora, Giorgio Cantelli Forti, Pasquale Perrone Filardi, Aldo P. Maggioni, Marcello Arca, Damiano Parretti, Gualtiero Ricciardi, Carmine Riccio, Raffaele Griffo, Maria Pia Ruggieri, Ferruccio Ceriotti, Enrico Pusineri, Michele Massimo Gulizia, Francesco Perticone, Furio Colivicchi, Francesco Romeo, Antonio Vittorio Panno, Nicoletta Musacchio, Federico Nardi, Maurizio Giuseppe Abrignani, Alessandro Mugelli, Marcello Ciaccio, Maria Stella Graziani, Gulizia, M., Colivicchi, F., Ricciardi, G., Giampaoli, S., Maggioni, A., Averna, M., Graziani, M., Ceriotti, F., Mugelli, A., Rossi, F., Medea, G., Parretti, D., Abrignani, M., Arca, M., Perrone Filardi, P., Perticone, F., Catapano, A., Griffo, R., Nardi, F., Riccio, C., Di Lenarda, A., Scherillo, M., Musacchio, N., Panno, A., Zito, G., Campanini, M., Bolognese, L., Faggiano, P., Musumeci, G., Pusineri, E., Ciaccio, M., Bonora, E., Cantelli Forti, G., Ruggieri, M., Cricelli, C., Romeo, F., Ferrari, R., Maseri, A., Gulizia, Mm, Colivicchi, F, Ricciardi, G, Giampaoli, S, Maggioni, Ap, Averna, M, Graziani, M, Ceriotti, F, Mugelli, A, Rossi, F, Medea, G, Parretti, D, Abrignani, Mg, Arca, M, Perrone Filardi, P, Perticone, F, Catapano, A, Griffo, R, Nardi, F, Riccio, C, Di Lenarda, A, Scherillo, M, Musacchio, N, Panno, Av, Zito, G, Campanini, M, Bolognese, L, Faggiano, Pm, Musumeci, M, Pusineri, E, Ciaccio, M, Bonora, E, Cantelli Forti, G, Ruggieri, Mp, Cricelli, C, Romeo, F, Ferrari, R, and Maseri, A
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medicine.medical_specialty ,Settore MED/09 - Medicina Interna ,PCSK9 inhibitor ,MEDLINE ,030204 cardiovascular system & hematology ,NO ,atherosclerosis ,diagnostic and therapeutic pathways ,hypercholesterolaemia ,PCSK9 inhibitors ,statins ,sustainable health care ,Diagnostic and therapeutic pathways ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ezetimibe ,Internal medicine ,Diabetes mellitus ,medicine ,030212 general & internal medicine ,Intensive care medicine ,Risk management ,Cause of death ,Hypercholesterolaemia ,business.industry ,Atherosclerotic cardiovascular disease ,Cholesterol ,Sustainable health care ,Statins ,Diagnostic and therapeutic pathway ,Statin ,High Cholesterol Levels ,Articles ,medicine.disease ,Atherosclerosis ,chemistry ,Atherosclerosi ,Cardiology ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Atherosclerotic cardiovascular disease still represents the leading cause of death in western countries. A wealth of scientific evidence demonstrates that increased blood cholesterol levels have a major impact on the outbreak and progression of atherosclerotic plaques. Moreover, several cholesterol-lowering pharmacological agents, including statins and ezetimibe, have proven effective in improving clinical outcomes. This document is focused on the clinical management of hypercholesterolemia and has been conceived by 16 Italian medical associations with the support of the Italian National Institute of Health. The authors have considered with particular attention the role of hypercholesterolemia in the genesis of atherosclerotic cardiovascular disease. Besides, the implications of high cholesterol levels in the definition of the individual cardiovascular risk profile have been carefully analyzed, while all available therapeutic options for blood cholesterol reduction and cardiovascular risk mitigation have been considered. Finally, this document outlines the diagnostic and therapeutic pathways for the clinical management of patients with hypercholesterolemia.
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- 2017
230. Physiological and paraphysiological echocardiographic findings in neonatal and pediatric age
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Maria Giovanna, Russo, Annapaola, Cirillo, Gabriele, Rinelli, Ugo, Vairo, Silvia, Favilli, Antonella, Moreo, Stefano, Domenicucci, Michele Massimo, Gulizia, Domenico, Gabrielli, Russo, Mg., Cirillo, A., Rinelli, G., Vairo, U., Favilli, S., Moreo, A., Domenicucci, S., Gulizia, M. M., and Gabrielli, D.
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Heart Defects, Congenital ,congenital, hereditary, and neonatal diseases and abnormalities ,Heart Diseases ,Infant, Newborn ,Foramen Ovale, Patent ,Infant ,Heart Septal Defects, Atrial ,Echocardiography ,Humans ,cardiovascular diseases ,Child ,Ductus Arteriosus, Patent ,Pediatric age ,Congenital heart disease - Abstract
Echocardiographic quantification is crucial for the diagnosis and management of patients with acquired and congenital heart disease (CHD). In neonatal and pediatric age, the echocardiogram begins with subxiphoid, or subcostal, imaging instead of left parasternal views. This allows for the determination of visceral situs (site or location) at the beginning of an examination. Regardless of where the examination starts, the segmental approach is used to describe all of the major cardiovascular structures in sequence. Patent foramen ovale is a normal interatrial communication during fetal life. Complete anatomic closure of the foramen ovale occurs in 70-75% of adults, which means that almost 25% of the population has a patent foramen ovale. Atrial septal defects are a common congenital disorder with a prevalence of approximately 2 per 1000 live births. The reported rate of spontaneous atrial septal defect closure in the first year of life ranges from 4% to 96%. The most important predictor for spontaneous closure is the size of the defect, with smaller defects more likely to close. Systemic-to-pulmonary collateral arteries can occur in premature infants without chronic lung disease and may represent a transient phenomenon. They may be present normally after birth and then gradually disappear. Physiological valvular regurgitation is most commonly observed in the tricuspid valve among children (32.8%), followed by pulmonary regurgitation (17.2%). The ductus arteriosus usually is functionally closed within 48 h of birth, although some authors consider the patent ductus to be abnormal only after 3 months of age. Prematurity clearly increases the incidence of patent ductus arteriosus.
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- 2019
231. Fertilizing a patient engagement ecosystem to innovate healthcare: Toward the first Italian Consensus conference on patient engagement
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Guendalina Graffigna, Serena Barello, Giuseppe Riva, Mariarosaria Savarese, Julia Menichetti, Gianluca Castelnuovo, Massimo Corbo, Alessandra Tzannis, Antonio Aglione, Donato Bettega, Anna Bertoni, Sarah Bigi, Daniela Bruttomesso, Claudia Carzaniga, Laura Del Campo, Silvia Donato, Silvia Gilardi, Chiara Guglielmetti, Michele Gulizia, Mara Lastretti, Valeria Mastrilli, Antonino Mazzone, Giovanni Muttillo, Silvia Ostuzzi, Gianluca Perseghin, Natalia Piana, Giuliana Pitacco, Gianluca Polvani, Massimo Pozzi, Livio Provenzi, Giulia Quaglini, Mariagrazia Rossi, Paola Varese, Natalia Visalli, Elena Vegni, Walter Ricciardi, A. Claudio Bosio, Graffigna, G, Barello, S, Riva, G, Savarese, M, Menichetti, J, Castelnuovo, G, Corbo, M, Tzannis, A, Aglione, A, Bettega, D, Bertoni, A, Bigi, S, Bruttomesso, D, Carzaniga, C, Campo, L, Donato, S, Gilardi, S, Guglielmetti, C, Gulizia, M, Lastretti, M, Mastrilli, V, Mazzone, A, Muttillo, G, Ostuzzi, S, Perseghin, G, Piana, N, Pitacco, G, Polvani, G, Pozzi, M, Provenzi, L, Quaglini, G, Rossi, M, Varese, P, Visalli, N, Vegni, E, Ricciardi, W, and Bosio, A
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Psychology (all) ,media_common.quotation_subject ,lcsh:BF1-990 ,Psychological intervention ,Patient engagement ,Settore M-PSI/06 - PSICOLOGIA DEL LAVORO E DELLE ORGANIZZAZIONI ,Context (language use) ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Promotion (rank) ,law ,Health care ,Psychology ,030212 general & internal medicine ,Disengagement theory ,MED/13 - ENDOCRINOLOGIA ,Chronic care ,Consensus conference ,Italy ,General Psychology ,media_common ,M-PSI/05 - PSICOLOGIA SOCIALE ,Marketing buzz ,business.industry ,030503 health policy & services ,Public relations ,lcsh:Psychology ,CLARITY ,0305 other medical science ,business ,Social psychology - Abstract
Currently we observe a gap between theory and practices of patient engagement. If both scholars and health practitioners do agree on the urgency to realize patient engagement, no shared guidelines exist so far to orient clinical practice. Despite a supportive policy context, progress to achieve greater patient engagement is patchy and slow and often concentrated at the level of policy regulation without dialoguing with practitioners from the clinical field as well as patients and families. Though individual clinicians, care teams and health organizations may be interested and deeply committed to engage patients and family members in the medical course, they may lack clarity about how to achieve this goal. This contributes to a wide "system" inertia-really difficult to be overcome-and put at risk any form of innovation in this filed. As a result, patient engagement risk today to be a buzz words, rather than a real guidance for practice. To make the field clearer, we promoted an Italian Consensus Conference on Patient Engagement (ICCPE) in order to set the ground for drafting recommendations for the provision of effective patient engagement interventions. The ICCPE will conclude in June 2017. This document reports on the preliminary phases of this process. In the paper, we advise the importance of "fertilizing a patient engagement ecosystem": an oversimplifying approach to patient engagement promotion appears the result of a common illusion. Patient "disengagement" is a symptom that needs a more holistic and complex approach to solve its underlined causes. Preliminary principles to promote a patient engagement ecosystem are provided in the paper.
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- 2017
232. ANMCO/SIC/SICI-GISE/SICCH Executive Summary of Consensus Document on Risk Stratification in elderly patients with aortic stenosis before surgery or transcatheter aortic valve replacement
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Giuseppe Musumeci, Adriano Murrone, Samuele Baldasseroni, Annalisa Mongiardo, Giovanni Pulignano, Giovanni Cioffi, Francesco Bedogni, Roberto Di Bartolomeo, Ciro Indolfi, Carmen Spaccarotella, Leonardo Patanè, Michele Massimo Gulizia, Francesco Romeo, Alessandro Parolari, Francesco Musumeci, Paolo Giuseppe Pino, Pulignano, Giovanni, Gulizia, Michele Massimo, Baldasseroni, Samuele, Bedogni, Francesco, Cioffi, Giovanni, Indolfi, Ciro, Romeo, Francesco, Murrone, Adriano, Musumeci, Francesco, Parolari, Alessandro, Patanã, Leonardo, Pino, Paolo Giuseppe, Mongiardo, Annalisa, Spaccarotella, Carmen, Di Bartolomeo, Roberto, Musumeci, Giuseppe, Pulignano, G., Gulizia, M. M., Baldasseroni, S., Bedogni, F., Cioffi, G., Indolfi, C., Romeo, F., Murrone, A., Musumeci, F., Parolari, A., Patane, L., Pino, P. G., Mongiardo, A., Spaccarotella, C., Di Bartolomeo, R., and Musumeci, G.
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medicine.medical_specialty ,Aortic stenosi ,Prognosi ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,TAVI ,03 medical and health sciences ,0302 clinical medicine ,Elderly ,Valve replacement ,Quality of life ,Intervention (counseling) ,medicine ,030212 general & internal medicine ,Framingham Risk Score ,Frailty ,business.industry ,Public health ,Aortic stenosis ,Articles ,SAVR ,medicine.disease ,Prognosis ,Geriatric assessment ,Surgery ,Stenosis ,Life expectancy ,Risk score ,business ,Cardiology and Cardiovascular Medicine ,Developed country - Abstract
Aortic stenosis is one of the most frequent valvular diseases in developed countries, and its impact on public health resources and assistance is increasing. A substantial proportion of elderly people with severe aortic stenosis is not eligible to surgery because of the advanced age, frailty, and multiple co-morbidities. Transcatheter aortic valve implantation (TAVI) enables the treatment of very elderly patients at high or prohibitive surgical risk considered ineligible for surgery and with an acceptable life expectancy. However, a significant percentage of patients die or show no improvement in quality of life (QOL) in the follow-up. In the decision-making process, it is important to determine: (i) whether and how much frailty of the patient influences the risk of procedures; (ii) how the QOL and the individual patient’s survival are influenced by aortic valve disease or from other associated conditions; and (iii) whether a geriatric specialist intervention to evaluate and correct frailty or other diseases with their potential or already manifest disabilities can improve the outcome of surgery or TAVI. Consequently, in addition to risk stratification with conventional tools, a number of factors including multi-morbidity, disability, frailty, and cognitive function should be considered, in order to assess the expected benefit of both surgery and TAVI. The pre-operative optimization through a multidisciplinary approach with a Heart Team can counteract the multiple damage (cardiac, neurological, muscular, respiratory, and kidney) that can potentially aggravate the reduced physiological reserves characteristic of frailty. The systematic application in clinical practice of multidimensional assessment instruments of frailty and cognitive function in the screening and the adoption of specific care pathways should facilitate this task.
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- 2017
233. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial
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Marco Dauriz, Giovanni Targher, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Gian Luigi Nicolosi, Roberto Marchioli, Gianni Tognoni, Roberto Latini, Franco Cosmi, Luigi Tavazzi, Aldo Pietro Maggioni, Simona Barlera, Maria Grazia Franzosi, Aldo P. Maggioni, Maurizio Porcu, Salim Yusuf, Fulvio Camerini, Jay N. Cohn, Adriano Decarli, Bertram Pitt, Peter Sleight, Philip A. Poole‐Wilson, Enrico Geraci, Marino Scherillo, Gianna Fabbri, Barbara Bartolomei, Daniele Bertoli, Franco Cobelli, Claudio Fresco, Antonietta Ledda, Giacomo Levantesi, Cristina Opasich, Franco Rusconi, Gianfranco Sinagra, Fabio Turazza, Alberto Volpi, Martina Ceseri, Gianluca Alongi, Antonio Atzori, Filippo Bambi, Desiree Bastarolo, Francesca Bianchini, Iacopo Cangioli, Vittoriana Canu, Concetta Caporusso, Gabriele Cenni, Laura Cintelli, Michele Cocchio, Alessia Confente, Eva Fenicia, Giorgio Friso, Marco Gianfriddo, Gianluca Grilli, Beatrice Lazzaro, Giuseppe Lonardo, Alessia Luise, Rachele Nota, Mariaelena Orlando, Rosaria Petrolo, Chiara Pierattini, Valeria Pierota, Alessandro Provenzani, Velia Quartuccio, Anna Ragno, Chiara Serio, Alvise Spolaor, Arianna Tafi, Elisa Tellaroli, Stefano Ghio, Elisa Ghizzardi, Serge Masson, Lella Crociati, Maria Teresa La Rovere, Ugo Corrà, Andrea Finzi, Marco Gorini, Valentina Milani, Giampietro Orsini, Elisa Bianchini, Silvia Cabiddu, Ilaria Cangioli, Laura Cipressa, Maria Lucia Cipressa, Giuseppina Di Bitetto, Barbara Ferri, Luisa Galbiati, Andrea Lorimer, Carla Pera, Paola Priami, Antonella Vasamì, T. Moccetti, M.G. Rossi, E. Pasotti, F. Vaghi, P. Roncarolo, M.T. Zunino, F. Matta, E. Actis Perinetto, F. Gaita, G. Azzaro, M. Zanetta, A.M. Paino, U. Parravicini, D. Vegis, R. Conte, P. Ferraro, A. De Bernardi, S. Morelloni, M. Fagnani, P. Greco Lucchina, L. Montagna, E. Bellone, D. Sappè, F. Ferraro, M. Delucchi, S.G. Reynaud, M. Dore, A. La Brocca, N. Massobrio, L. Bo, R. Trinchero, M. Imazio, G. Brocchi, A. Nejrotti, L. Rissone, S. Gabasio, C. Zocchi, S. Randazzo, A. Crenna, P. Giannuzzi, E. Bonanomi, A. Mezzani, M. De Marchi, G. Begliuomini, C.A. Gianonatti, A. Gavazzi, A. Grosu, L. Dei Cas, S. Nodari, P. Garyfallidis, A. Bertoletti, C. Bonifazi, S. Arisi, F. Mascaro, M. Fraccarollo, S. Dell'Orto, M. Sfolcini, F. Bortolini, D. Raccagni, A. Turelli, M. Santarone, E. Miglierina, L. Sormani, R. Jemoli, F. Tettamanti, S. Pirelli, C. Bianchi, S. Verde, M. Mariani, V. Ziacchi, A. Ferrazza, A. Russo, M. Bortolotti, G.F. Pasini, A. Volpi, K.N. Jones, D. Cuzzucrea, G. Gullace, C. Carbone, A. Granata, S. De Servi, G. Del Rosso, C. Inserra, E. Renaldini, C. Zappa, M. Moretti, R. Zanini, M. Ferrari, E. Moroni, A. Cei, C. Lissi, E. Dovico, C. Fiorentini, P. Palermo, B. Brusoni, M. Negrini, J. Heyman, G.B. Danzi, A. Finzi, M. Frigerio, F. Turazza, L. Beretta, A. Sachero, F. Casazza, L. Squadroni, F. Lombardi, L. Marano, A. Margonato, G. Fragasso, O.C. Febo, E. Aiolfi, F. Olmetti, A. Grieco, V. Antonazzo, G. Specchia, A. Mortara, F. Robustelli, M.G. Songini, C. Schweiger, A. Frisinghelli, M. Palvarini, C. Campana, L. Scelsi, N. Ajmone Marsan, F. Cobelli, A. Gualco, C. Opasich, S. De Feo, R. Mazzucco, M.A. Iannone, T. Diaco, D. Zaniboni, G. Milanesi, D. Nassiacos, S. Meloni, P. Giani, T. Nicoli, C. Malinverni, A. Gusmini, L. Pozzoni, G. Bisiani, P. Margaroli, A. Schizzarotto, A. Daverio, G. Occhi, N. Partesana, P. Bandini, M.G. Rosella, S. Giustiniani, G. Cucchi, R. Pedretti, R. Raimondo, R. Vaninetti, A. Fedele, I. Ghezzi, E. Rezzonico, J.A. Salerno Uriarte, F. Morandi, F. Salvucci, C. Valenti, G. Graziano, M. Romanò, C. Cimminiello, I. Mangone, M. Lombardo, P. Quorso, G. Marinoni, M. Breghi, M. Erckert, A. Dienstl, G. Mirante Marini, C. Stefenelli, G. Cioffi, E. Buczkowska, A. Bonanome, F. Bazzanini, L. Parissenti, C. Serafini, G. Catania, L. Tarantini, G. Rigatelli, S. Boni, A. Pasini, E. Masini, A.A. Zampiero, M. Zanchetta, L. Franceschetto, P. Delise, C. Marcon, A. Sacchetta, L. Borgese, L. Artusi, P. Casolino, F. Corbara, A. Banzato, M. Barbiero, M.P. Aldegheri, R. Bazzucco, G. Crivellenti, A. Raviele, C. Zanella, P. Pascotto, P. Sarto, S. Milan, E. Barbieri, P. Girardi, W. Dalla Villa, J. Dalle Mule, M.L. Di Sipio, R. Cazzin, D. Milan, P. Zonzin, M. Carraro, R. Rossi, E. Carbonieri, I. Rossi, P. Stritoni, P. Meneghetti, G. Risica, P.L. Tenderini, C. Vassanelli, L. Zanolla, G. Perini, G. Brighetti, R. Chiozza, G. Giuliano, R. Gortan, R. Cesanelli, G.L. Nicolosi, R. Piazza, L. Mos, O. Vriz, D. Pavan, G. Pascottini, E. Alberti, M. Werren, L. Solinas, G. Sinagra, F. Longaro, P. Fioretti, M.C. Albanese, D. Miani, R. Gianrossi, A. Pende, P. Rubartelli, O. Magaia, S. Domenicucci, D. Caruso, A.S. Faraguti, L. Magliani, F. Miccoli, G. Guglielmino, D. Bertoli, A. Cantarelli, S. Orlandi, A. Vallebona, A. Pozzati, G. Brega, L.G. Pancaldi, R. Vandelli, S. Urbinati, M.G. Poci, M. Zoli, G.M. Costa, U. Guiducci, G. Zobbi, F. Tartagni, A. Tisselli, A. Gentili, P. Pieri, E. Cagnetta, S. Bendinelli, A. Barbieri, R. Conti, R. Ferrari, F. Merlini, A. Fucili, P. Moruzzi, E. Buia, M. Galvani, D. Ferrini, G. Baggioni, P. Yiannacopulu, G. Canè, A. Bonfiglioli, R. Zandomeneghi, L. Brugioni, A. Giannini, R. Di Ruvo, M. Giuliani, L. Rusconi, P. Del Corso, G. Piovaccari, F. Bologna, P. Venturi, F. Melandri, E. Bagni, L. Bolognese, R. Perticucci, A. Zuppiroli, M. Nannini, N. Consoli, P. Petrone, C. Pipitò, L. Colombi, D. Bernardi, P.R. Mariani, R. Testa, F. Mazzinghi, F. Cosmi, D. Cosmi, A. Zipoli, A. Cecchi, G. Castelli, M. Ciaccheri, F. Mori, F. Pieri, P. Valoti, D. Chiarantini, G.M. Santoro, C. Minneci, F. Marchi, M. Milli, G. Zambaldi, A.A. Brandinelli Geri, M. Cipriani, M. Alessandri, S. Severi, S. Stefanelli, A. Comella, R. Poddighe, A. Digiorgio, M. Carluccio, S. Berti, A. Rizza, V. Bonatti, V. Molendi, A. Brancato, N. D'Aprile, G. Giappichini, S. Del Vecchio, G. Mantini, F. De Tommasi, G. Meucci, M. Cordoni, S. Bechi, L. Barsotti, P. Baldini, M. Romei, G. Scopelliti, G. Lauri, F. Pestelli, F. Furiozzi, M. Cocchieri, D. Severini, F. Patriarchi, P. Chiocchi, M. Buccolieri, S. Martinelli, A. Wee, F. Angelici, M. Bernardinangeli, G. Proietti, B. Biscottini, R. Panciarola, L. Marinacci, G.P. Perna, D. Gabrielli, A. Moraca, L. Moretti, L. Partemi, G. Gregori, R. Amici, G. Patteri, P. Capone, E. Savini, G.L. Morgagni, L. Paccaloni, F. Pezzuoli, S. Carincola, S. Papi, S. De Crescentini, P. Gerardi, P. Midi, E. Gallenzi, G. Pajes, C. Mancone, V. Di Spirito, M. Di Gennaro, S. Calcagno, S. Toscano, S. Antonicoli, F. Carta, G. Giorgi, F. Comito, E. Daniele, O. Ciarla, P.G. Gelfo, A. Acquaviva, D. Testa, G. Testa, F.A. Pagliaro, F. Russo, F. Vetta, I. Marchese, G. Di Sciascio, A. D'Ambrosio, F. Leggio, D. Del Sindaco, A. Lacchè, A. Avallone, M.P. Risa, P. Azzolini, E. Baldo, E. Giovannini, G. Pulignano, C. Tondo, E. Picchio, E. ani, P. Tanzi, F. Pozzar, F. Farnetti, M. Azzarito, M. Santini, A. Varveri, G. Ferraiuolo, C. Valtorta, A. Gaspardone, G. Barbato, V. Ceci, N. Aspromonte, F. Bellocci, C. Colizzi, F. Fedele, F.I. Perez, A. Galati, A. Rossetti, A. Mainella, D. etta, C. Matteucci, G. Busi, A. De Angelis, G. Farina, A. Granatelli, F. Leone, F. Frasca, R. Di Giovambattista, G. Castellani, G. Massaro, G. Mastrogiuseppe, A. Vacri, F. De Sanctis, M. Cioli, S. Di Luzio, C. Napoletano, L.L. Piccioni, G. De Simone, A. Ottaviano, V. Mazza, C. Spedaliere, D. Staniscia, E. Calgione, G. De Marco, T. Chiacchio, T. Di Napoli, S. Romanzi, G. Salvatore, P. Golino, A. Palermo, F. Mascia, A. Vetrano, A. Vinciguerra, L. Caliendo, R. Longobardi, G. De Caro, R. Di Nola, F. Piemonte, D. Prinzi, P. De Rosa, V. De Rosa, F. Riello, V. Capuano, G. Vecchio, M. Landi, S. Amato, M. Garofalo, M. D'Avino, P. Sensale, O. Maiolica, R. Santoro, P. Caso, D. Miceli, N. Maurea, U. Bianchi, C. Crispo, M. Chiariello, P. Perrone Filardi, L. Russo, N. Capuano, G. Ungaro, G. Vergara, F. Scafuro, G. D'Angelo, C. Campaniello, P. Bottiglieri, A. Volpe, R. Battista, L. De Risi, G. Cardillo, G. Sibilio, A.P. Marino, F. Silvestri, P. Predotti, A. Iervoglini, C. De Matteis, P. Sarnicola, M.M. Matarazzo, S. Baldi, V. Iuliano, C. Astarita, P. Cuccaro, A. Liguori, G. Liguori, G. Gregorio, L. Petraglia, G. Antonelli, G. Amodio, I. De Luca, D. Traversa, G. Franchini, M.L. Lenti, D. Cavallari, C. D'Agostino, G. Scalera, C.M. Altamura, M. Russo, A.R. Mascolo, G. Pettinati, S.A. Ciricugno, D. Scrutinio, A. Passantino, D. Mastrangelo, A. Di Masi, R. De Carne, M. Cannone, F. Dibiase, M. Pensato, F. Loliva, F. Trapani, I. Panettieri, L. Leone, M. Di Biase, M. Carrone, V. Gallone, F. Cocco, M. Costantini, C. Tritto, F. Cavalieri, L. Stella, F. Magliari, M. Callerame, A. De Giorgi, L. Pellegrino, M. Correra, V. Portulano, G.L. Nisi, G. Grassi, E. Cristallo, D. De Laura, C. Salerno, R. Fanelli, M. Villella, S. Pede, A. Renna, E. De Lorenzi, L. Urso, V. Lenti, A. Peluso, N. Baldi, G. Polimeni, P. Palma, R. Lauletta, E. Tagliamonte, T. Cirillo, B. Silvestri, G. Centonze, B. D'Alessandro, L. Truncellito, D. Mecca, M.A. Petruzzi, R.O.M. Coviello, A. Lopizzo, M. telli, S. Barbuzzi, S. Gubelli, G. Germinario, N. Cosentino, A. Mingrone, R. Vico, G. Borrello, M.L. Mazza, R. Cimino, D. Galasso, F. Cassadonte, U. Talarico, F. Perticone, S. Cassano, F. Catapano, S. Calemme, E. Feraco, C. Cloro, G. Misuraca, R. Caporale, L. Vigna, V. Spagnuolo, F. De Rosa, G. Spadafora, G. Zampaglione, R. Russo, F.A. Schipani, A.F. Ferragina, D. Stranieri, G. Musca, C. Carpino, P. Bencardino, F. Raimondo, D. Musacchio, G. Pulitanò, A. Ruggeri, A. Provenzano, S. Salituri, M. Musolino, S. Calandruccio, A. Marrari, E. Tripodi, R. Scali, L. Anastasio, A. Arone, P. Aragona, L. Donnangelo, M.G.A. Comito, F. Bilotta, I. Vaccaro, R. Rametta, V. Ventura, A. Bonvegna, A. Alì, C. Cinnirella, M. Raineri, F. Pompeo, N. Cascio Ingurgio, V. Carini, R. Coco, G. Giunta, G. Leonardi, V. Randazzo, V. Di Blasi, C. Tamburino, G. Russo, S. Mangiameli, R. Cardillo, D. Castelli, V. Inserra, A. Arena, M.M. Gulizia, S. Raciti, G. Rapisarda, R. Romano, P. Prestifilippo, G.B. Braschi, G. Ledda, R. Terrazzino, M. De Caro, G. Scilabra, B. agnino, R. Grassi, G. Di Tano, G.F. Scimone, L. Vasquez, C. Coppolino, A. Casale, M. Castelli, G. D'Urso, E. D'Antonio, L. Lo Presti, E. Badalamenti, P. Conti, N. Sanfilippo, V. Cirrincione, M.T. Cinà, G. Cusimano, A. Taormina, P. Giuliano, A. Bajardi, V. Mandalà, A. Canonico, G. Geraci, F.P. Sabella, F. Enia, A.M. Floresta, I. Lo Cascio, D. Gumina, A. Cavallaro, G. Piccione, R. Ferrante, M. Blandino, M.S. Iudicello, E. Mossuti, G. Romano, L. Lombardo, P. Monastra, D. Di Vincenzo, M. Porcu, P. Orrù, F. Muscas, G. Giardina, M. Corda, G. Locci, A. Podda, M. Ledda, P. Siddi, C. Lai, G. Pili, G. Mercuro, G. Mureddu, A. Ganau, G. Meloni, G. Poddighe, G. Sanna, Dauriz, Marco, Targher, Giovanni, Temporelli, Pier Luigi, Lucci, Donata, Gonzini, Lucio, Nicolosi, Gian Luigi, Marchioli, Roberto, Tognoni, Gianni, Latini, Roberto, Cosmi, Franco, Tavazzi, Luigi, Maggioni, Aldo Pietro, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, Moccetti, T., Rossi, M. G., Pasotti, E., Vaghi, F., Roncarolo, P., Zunino, M. T., Matta, F., Actis Perinetto, E., Gaita, F., Azzaro, G., Zanetta, M., Paino, A. M., Parravicini, U., Vegis, D., Conte, R., Ferraro, P., De Bernardi, A., Morelloni, S., Fagnani, M., Greco Lucchina, P., Montagna, L., Bellone, E., Sappè, D., Ferraro, F., Delucchi, M., Reynaud, S. G., Dore, M., La Brocca, A., Massobrio, N., Bo, L., Trinchero, R., Imazio, M., Brocchi, G., Nejrotti, A., Rissone, L., Gabasio, S., Zocchi, C., Randazzo, S., Crenna, A., Giannuzzi, P., Bonanomi, E., Mezzani, A., De Marchi, M., Begliuomini, G., Gianonatti, C. A., Gavazzi, A., Grosu, A., Dei Cas, L., Nodari, S., Garyfallidis, P., Bertoletti, A., Bonifazi, C., Arisi, S., Mascaro, F., Fraccarollo, M., Dell'Orto, S., Sfolcini, M., Bortolini, F., Raccagni, D., Turelli, A., Santarone, M., Miglierina, E., Sormani, L., Jemoli, R., Tettamanti, F., Pirelli, S., Bianchi, C., Verde, S., Mariani, M., Ziacchi, V., Ferrazza, A., Russo, A., Bortolotti, M., Pasini, G. F., Volpi, A., Jones, K. N., Cuzzucrea, D., Gullace, G., Carbone, C., Granata, A., De Servi, S., Del Rosso, G., Inserra, C., Renaldini, E., Zappa, C., Moretti, M., Zanini, R., Ferrari, M., Moroni, E., Cei, A., Lissi, C., Dovico, E., Fiorentini, C., Palermo, P., Brusoni, B., Negrini, M., Heyman, J., Danzi, G. B., Finzi, A., Frigerio, M., Turazza, F., Beretta, L., Sachero, A., Casazza, F., Squadroni, L., Lombardi, F., Marano, L., Margonato, A., Fragasso, G., Febo, O. C., Aiolfi, E., Olmetti, F., Grieco, A., Antonazzo, V., Specchia, G., Mortara, A., Robustelli, F., Songini, M. G., Schweiger, C., Frisinghelli, A., Palvarini, M., Campana, C., Scelsi, L., Ajmone Marsan, N., Cobelli, F., Gualco, A., Opasich, C., De Feo, S., Mazzucco, R., Iannone, M. A., Diaco, T., Zaniboni, D., Milanesi, G., Nassiacos, D., Meloni, S., Giani, P., Nicoli, T., Malinverni, C., Gusmini, A., Pozzoni, L., Bisiani, G., Margaroli, P., Schizzarotto, A., Daverio, A., Occhi, G., Partesana, N., Bandini, P., Rosella, M. G., Giustiniani, S., Cucchi, G., Pedretti, R., Raimondo, R., Vaninetti, R., Fedele, A., Ghezzi, I., Rezzonico, E., Salerno Uriarte, J. A., Morandi, F., Salvucci, F., Valenti, C., Graziano, G., Romanò, M., Cimminiello, C., Mangone, I., Lombardo, M., Quorso, P., Marinoni, G., Breghi, M., Erckert, M., Dienstl, A., Mirante Marini, G., Stefenelli, C., Cioffi, G., Buczkowska, E., Bonanome, A., Bazzanini, F., Parissenti, L., Serafini, C., Catania, G., Tarantini, L., Rigatelli, G., Boni, S., Pasini, A., Masini, E., Zampiero, A. A., Zanchetta, M., Franceschetto, L., Delise, P., Marcon, C., Sacchetta, A., Borgese, L., Artusi, L., Casolino, P., Corbara, F., Banzato, A., Barbiero, M., Aldegheri, M. P., Bazzucco, R., Crivellenti, G., Raviele, A., Zanella, C., Pascotto, P., Sarto, P., Milan, S., Barbieri, E., Girardi, P., Dalla Villa, W., Dalle Mule, J., Di Sipio, M. L., Cazzin, R., Milan, D., Zonzin, P., Carraro, M., Rossi, R., Carbonieri, E., Rossi, I., Stritoni, P., Meneghetti, P., Risica, G., Tenderini, P. L., Vassanelli, C., Zanolla, L., Perini, G., Brighetti, G., Chiozza, R., Giuliano, G., Baldin, M. G., Gortan, R., Cesanelli, R., Nicolosi, G. L., Piazza, R., Mos, L., Vriz, O., Pavan, D., Pascottini, G., Alberti, E., Werren, M., Solinas, L., Sinagra, G., Longaro, F., Fioretti, P., Albanese, M. C., Miani, D., Gianrossi, R., Pende, A., Rubartelli, P., Magaia, O., Domenicucci, S., Caruso, D., Faraguti, A. S., Magliani, L., Miccoli, F., Guglielmino, G., Bertoli, D., Cantarelli, A., Orlandi, S., Vallebona, A., Pozzati, A., Brega, G., Pancaldi, L. G., Vandelli, R., Urbinati, S., Poci, M. G., Zoli, M., Costa, G. M., Guiducci, U., Zobbi, G., Tartagni, F., Tisselli, A., Gentili, A., Pieri, P., Cagnetta, E., Bendinelli, S., Barbieri, A., Conti, R., Ferrari, R., Merlini, F., Fucili, A., Moruzzi, P., Buia, E., Galvani, M., Ferrini, D., Baggioni, G., Yiannacopulu, P., Canè, G., Bonfiglioli, A., Zandomeneghi, R., Brugioni, L., Giannini, A., Di Ruvo, R., Giuliani, M., Rusconi, L., Del Corso, P., Piovaccari, G., Bologna, F., Venturi, P., Melandri, F., Bagni, E., Bolognese, L., Perticucci, R., Zuppiroli, A., Nannini, M., Consoli, N., Petrone, P., Pipitò, C., Colombi, L., Bernardi, D., Mariani, P. R., Testa, R., Mazzinghi, F., Cosmi, F., Cosmi, D., Zipoli, A., Cecchi, A., Castelli, G., Ciaccheri, M., Mori, F., Pieri, F., Valoti, P., Chiarantini, D., Santoro, G. M., Minneci, C., Marchi, F., Milli, M., Zambaldi, G., Brandinelli Geri, A. A., Cipriani, M., Alessandri, M., Severi, S., Stefanelli, S., Comella, A., Poddighe, R., Digiorgio, A., Carluccio, M., Berti, S., Rizza, A., Bonatti, V., Molendi, V., Brancato, A., D'Aprile, N., Giappichini, G., Del Vecchio, S., Mantini, G., De Tommasi, F., Meucci, G., Cordoni, M., Bechi, S., Barsotti, L., Baldini, P., Romei, M., Scopelliti, G., Lauri, G., Pestelli, F., Furiozzi, F., Cocchieri, M., Severini, D., Patriarchi, F., Chiocchi, P., Buccolieri, M., Martinelli, S., Wee, A., Angelici, F., Bernardinangeli, M., Proietti, G., Biscottini, B., Panciarola, R., Marinacci, L., Perna, G. P., Gabrielli, D., Moraca, A., Moretti, L., Partemi, L., Gregori, G., Amici, R., Patteri, G., Capone, P., Savini, E., Morgagni, G. L., Paccaloni, L., Pezzuoli, F., Carincola, S., Papi, S., De Crescentini, S., Gerardi, P., Midi, P., Gallenzi, E., Pajes, G., Mancone, C., Di Spirito, V., Di Gennaro, M., Calcagno, S., Toscano, S., Antonicoli, S., Carta, F., Giorgi, G., Comito, F., Daniele, E., Ciarla, O., Gelfo, P. G., Acquaviva, A., Testa, D., Testa, G., Pagliaro, F. A., Russo, F., Vetta, F., Marchese, I., Di Sciascio, G., D'Ambrosio, A., Leggio, F., Del Sindaco, D., Lacchè, A., Avallone, A., Risa, M. P., Azzolini, P., Baldo, E., Giovannini, E., Pulignano, G., Tondo, C., Picchio, E., Biffani, E., Tanzi, P., Pozzar, F., Farnetti, F., Azzarito, M., Santini, M., Varveri, A., Ferraiuolo, G., Valtorta, C., Gaspardone, A., Barbato, G., Ceci, V., Aspromonte, N., Bellocci, F., Colizzi, C., Fedele, F., Perez, F. I., Galati, A., Rossetti, A., Mainella, A., Ciuffetta, D., Matteucci, C., Busi, G., De Angelis, A., Farina, G., Granatelli, A., Leone, F., Frasca, F., Di Giovambattista, R., Castellani, G., Massaro, G., Mastrogiuseppe, G., Vacri, A., De Sanctis, F., Cioli, M., Di Luzio, S., Napoletano, C., Piccioni, L. L., De Simone, G., Ottaviano, A., Mazza, V., Spedaliere, C., Staniscia, D., Calgione, E., De Marco, G., Chiacchio, T., Di Napoli, T., Romanzi, S., Salvatore, G., Golino, P., Palermo, A., Mascia, F., Vetrano, A., Vinciguerra, A., Caliendo, L., Longobardi, R., De Caro, G., Di Nola, R., Piemonte, F., Prinzi, D., De Rosa, P., De Rosa, V., Riello, F., Capuano, V., Vecchio, G., Landi, M., Amato, S., Garofalo, M., D'Avino, M., Sensale, P., Maiolica, O., Santoro, R., Caso, P., Miceli, D., Maurea, N., Bianchi, U., Crispo, C., Chiariello, M., Perrone Filardi, P., Russo, L., Capuano, N., Ungaro, G., Vergara, G., Scafuro, F., D'Angelo, G., Campaniello, C., Bottiglieri, P., Volpe, A., Battista, R., De Risi, L., Cardillo, G., Sibilio, G., Marino, A. P., Silvestri, F., Predotti, P., Iervoglini, A., De Matteis, C., Sarnicola, P., Matarazzo, M. M., Baldi, S., Iuliano, V., Astarita, C., Cuccaro, P., Liguori, A., Liguori, G., Gregorio, G., Petraglia, L., Antonelli, G., Amodio, G., De Luca, I., Traversa, D., Franchini, G., Lenti, M. L., Cavallari, D., D'Agostino, C., Scalera, G., Altamura, C. M., Russo, M., Mascolo, A. R., Pettinati, G., Ciricugno, S. A., Scrutinio, D., Passantino, A., Mastrangelo, D., Di Masi, A., De Carne, R., Cannone, M., Dibiase, F., Pensato, M., Loliva, F., Trapani, F., Panettieri, I., Leone, L., Di Biase, M., Carrone, M., Gallone, V., Cocco, F., Costantini, M., Tritto, C., Cavalieri, F., Stella, L., Magliari, F., Callerame, M., De Giorgi, A., Pellegrino, L., Correra, M., Portulano, V., Nisi, G. L., Grassi, G., Cristallo, E., De Laura, D., Salerno, C., Fanelli, R., Villella, M., Pede, S., Renna, A., De Lorenzi, E., Urso, L., Lenti, V., Peluso, A., Baldi, N., Polimeni, G., Palma, P., Lauletta, R., Tagliamonte, E., Cirillo, T., Silvestri, B., Centonze, G., D'Alessandro, B., Truncellito, L., Mecca, D., Petruzzi, M. A., Coviello, R. O. M., Lopizzo, A., Chiaffitelli, M., Barbuzzi, S., Gubelli, S., Germinario, G., Cosentino, N., Mingrone, A., Vico, R., Borrello, G., Mazza, M. L., Cimino, R., Galasso, D., Cassadonte, F., Talarico, U., Perticone, F., Cassano, S., Catapano, F., Calemme, S., Feraco, E., Cloro, C., Misuraca, G., Caporale, R., Vigna, L., Spagnuolo, V., De Rosa, F., Spadafora, G., Zampaglione, G., Russo, R., Schipani, F. A., Ferragina, A. F., Stranieri, D., Musca, G., Carpino, C., Bencardino, P., Raimondo, F., Musacchio, D., Pulitanò, G., Ruggeri, A., Provenzano, A., Salituri, S., Musolino, M., Calandruccio, S., Marrari, A., Tripodi, E., Scali, R., Anastasio, L., Arone, A., Aragona, P., Donnangelo, L., Comito, M. G. A., Bilotta, F., Vaccaro, I., Rametta, R., Ventura, V., Bonvegna, A., Alì, A., Cinnirella, C., Raineri, M., Pompeo, F., Cascio Ingurgio, N., Carini, V., Coco, R., Giunta, G., Leonardi, G., Randazzo, V., Di Blasi, V., Tamburino, C., Russo, G., Mangiameli, S., Cardillo, R., Castelli, D., Inserra, V., Arena, A., Gulizia, M. M., Raciti, S., Rapisarda, G., Romano, R., Prestifilippo, P., Braschi, G. B., Ledda, G., Terrazzino, R., De Caro, M., Scilabra, G., Graffagnino, B., Grassi, R., Di Tano, G., Scimone, G. F., Vasquez, L., Coppolino, C., Casale, A., Castelli, M., D'Urso, G., D'Antonio, E., Lo Presti, L., Badalamenti, E., Conti, P., Sanfilippo, N., Cirrincione, V., Cinà, M. T., Cusimano, G., Taormina, A., Giuliano, P., Bajardi, A., Mandalà, V., Canonico, A., Geraci, G., Sabella, F. P., Enia, F., Floresta, A. M., Lo Cascio, I., Gumina, D., Cavallaro, A., Piccione, G., Ferrante, R., Blandino, M., Iudicello, M. S., Mossuti, E., Romano, G., Lombardo, L., Monastra, P., Di Vincenzo, D., Porcu, M., Orrù, P., Muscas, F., Giardina, G., Corda, M., Locci, G., Podda, A., Ledda, M., Siddi, P., Lai, C., Pili, G., Mercuro, G., Mureddu, G., Ganau, A., Meloni, G., Poddighe, G., Sanna, G., Barlera, Simona, Franzosi, Maria Grazia, Porcu, Maurizio, Yusuf, Salim, Camerini, Fulvio, Cohn, Jay N., Decarli, Adriano, Pitt, Bertram, Sleight, Peter, Poole-Wilson, Philip A., Geraci, Enrico, Scherillo, Marino, Fabbri, Gianna, Bartolomei, Barbara, Bertoli, Daniele, Cobelli, Franco, Fresco, Claudio, Ledda, Antonietta, Levantesi, Giacomo, Opasich, Cristina, Rusconi, Franco, Sinagra, Gianfranco, Turazza, Fabio, Volpi, Alberto, Ceseri, Martina, Alongi, Gianluca, Atzori, Antonio, Bambi, Filippo, Bastarolo, Desiree, Bianchini, Francesca, Cangioli, Iacopo, Canu, Vittoriana, Caporusso, Concetta, Cenni, Gabriele, Cintelli, Laura, Cocchio, Michele, Confente, Alessia, Fenicia, Eva, Friso, Giorgio, Gianfriddo, Marco, Grilli, Gianluca, Lazzaro, Beatrice, Lonardo, Giuseppe, Luise, Alessia, Nota, Rachele, Orlando, Mariaelena, Petrolo, Rosaria, Pierattini, Chiara, Pierota, Valeria, Provenzani, Alessandro, Quartuccio, Velia, Ragno, Anna, Serio, Chiara, Spolaor, Alvise, Tafi, Arianna, Tellaroli, Elisa, Ghio, Stefano, Ghizzardi, Elisa, Masson, Serge, Crociati, Lella, La Rovere, Maria Teresa, Corrà, Ugo, Di Giulio, Paola, Finzi, Andrea, Gorini, Marco, Milani, Valentina, Orsini, Giampietro, Bianchini, Elisa, Cabiddu, Silvia, Cangioli, Ilaria, Cipressa, Laura, Cipressa, Maria Lucia, Di Bitetto, Giuseppina, Ferri, Barbara, Galbiati, Luisa, Lorimer, Andrea, Pera, Carla, Priami, Paola, and Vasamì, Antonella
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Blood Glucose ,Male ,Glycated Hemoglobin A ,heart failure ,Kaplan-Meier Estimate ,prediabetes ,030204 cardiovascular system & hematology ,time factors ,Settore MED/11 ,cause of death ,0302 clinical medicine ,Glycemic control ,prediabetic state ,Cause of Death ,italy ,middle aged ,Prevalence ,80 and over ,double-blind method ,blood glucose ,risk factors ,030212 general & internal medicine ,Prediabetes ,Rosuvastatin Calcium ,humans ,rosuvastatin calcium ,Cause of death ,Original Research ,Metabolic Syndrome ,Aged, 80 and over ,adult ,Chronic heart failure ,Diabetes mellitus ,Heart failure ,Mortality ,Cardiology and Cardiovascular Medicine ,Hazard ratio ,chronic heart failure ,diabetes mellitus ,glycemic control ,mortality ,Treatment Outcome ,Adolescent ,Biomarkers ,Chronic Disease ,Diabetes Mellitus ,Fatty Acids, Omega-3 ,Double-Blind Method ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Hospitalization ,Heart Failure ,Italy ,Prediabetic State ,Risk Assessment ,Proportional Hazards Models ,Risk Factors ,Time Factors ,risk assessment ,Middle Aged ,kaplan-meier estimate ,aged ,female ,Prediabete ,young adult ,Female ,omega-3 ,Human ,hospitalization ,Adult ,medicine.medical_specialty ,Diabetes mellitu ,proportional hazards models ,Time Factor ,hydroxymethylglutaryl-coa reductase inhibitors ,prevalence ,fatty acids ,03 medical and health sciences ,Young Adult ,male ,Internal medicine ,Post-hoc analysis ,glycated hemoglobin a ,medicine ,Intensive care medicine ,Aged ,Glycated Hemoglobin ,Proportional hazards model ,business.industry ,Risk Factor ,biomarkers ,Biomarker ,medicine.disease ,Clinical trial ,adolescent ,Proportional Hazards Model ,treatment outcome ,aged, 80 and over ,chronic disease ,fatty acids, omega-3 ,cardiology and cardiovascular medicine ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business - Abstract
Background The independent prognostic impact of diabetes mellitus ( DM ) and prediabetes mellitus (pre‐ DM ) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐ DM on survival outcomes in the GISSI ‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) trial. Methods and Results We assessed the risk of all‐cause death and the composite of all‐cause death or cardiovascular hospitalization over a median follow‐up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI ‐ HF trial, who were stratified by presence of DM (n=2852), pre‐ DM (n=2013), and non‐ DM (n=2070) at baseline. Compared with non‐ DM patients, those with DM had remarkably higher incidence rates of all‐cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non‐ DM patients and those with pre‐ DM . Cox regression analysis showed that DM , but not pre‐ DM , was associated with an increased risk of all‐cause death (adjusted hazard ratio, 1.43; 95% CI , 1.28–1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI , 1.13–1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all‐cause death: adjusted hazard ratio, 1.21; 95% CI , 1.02–1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI , 1.01–1.29, respectively). Conclusions Presence of DM was independently associated with poor long‐term survival outcomes in patients with chronic heart failure. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 00336336.
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- 2017
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234. Presence and Duration of Atrial Fibrillation Detected by Continuous Monitoring: Crucial Implications for the Risk of Thromboembolic Events
- Author
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Giorgio Corbucci, Luigi Padeletti, Giovanni Russo, Marco Vimercati, Giuseppe Boriani, Michele Gulizia, Mauro Biffi, Stefano Favale, Alessandro Capucci, Giulio Molon, Massimo Santini, Giovanni L. Botto, Francesco Zolezzi, Renato Ricci, Botto GL, Padeletti L, Santini M, Capucci A, Gulizia M, Zolezzi F, Favale S, Molon G, Ricci R, Biffi M, Russo G, Vimercati M, Corbucci G, and Boriani G.
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Male ,medicine.medical_specialty ,Comorbidity ,Risk Assessment ,Asymptomatic ,Electrocardiography ,Risk Factors ,Thromboembolism ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,Ambulatory ,medicine ,Humans ,Stroke ,Aged ,medicine.diagnostic_test ,business.industry ,Incidence ,Incidence (epidemiology) ,Atrial fibrillation ,Prognosis ,medicine.disease ,Italy ,Heart failure ,Electrocardiography, Ambulatory ,Female ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Risk assessment ,business - Abstract
AF and the Risk of Thromboembolic Events. Introduction: Asymptomatic atrial fibrillation (AF) can expose patients to the risk of stroke. The primary objective of this study was to assess the incidence of thromboembolic events in relationship with CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke, or transient ischemic attack) score and AF presence/duration. The secondary objective was to compare intermittent versus continuous monitoring strategies. Methods and Results: Data from patients with an implanted pacemaker and a history of AF were analyzed. Thromboembolic risk was quantified through CHADS2 score. Three AF groups were considered: patients with 5-minutes AF on 1 day but 24 hours (AF-24 hours). Monitoring strategies involving 24-hour Holter, 1-week Holter, and 30-day Holter were simulated. Data from 568 patients continuously monitored for 1 year were analyzed: 171 (30%) had CHADS2 score = 0; 269 (47%) had CHADS2 score = 1; 111 (20%) had CHADS2 score = 2; and 17 (3%) had CHADS2 score ≥ 3. During follow-up, 14 patients (2.5%) had an ischemic thromboembolic event. AF-24 hours patients numbered 223 (39.2%); AF-5 minutes, 179 (31.5%); and AF-free, 29.2%. By combining AF presence/duration with CHADS2 score, two subpopulations with markedly different risks of events (0.8% vs 5%, P = 0.035) were identified, the former corresponding to AF-free with CHADS2≤2, or AF-5 minutes with CHADS2≤1, or AF-24 hours with CHADS2= 0. The mean sensitivity in detecting an AF episode lasting >5 minutes was 44.4%, 50.4%, and 65.1% for 24-hour Holter, 1-week Holter, and 1-month Holter monitoring, respectively. Conclusion: In patients with recurrent AF episodes, risk stratification for thromboembolic events can be improved by combining CHADS2 score with AF presence/duration. (J Cardiovasc Electrophysiol, Vol. 20, pp. 241-248, March 2009)
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- 2008
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235. Randomized comparison between Ramp and Burst+ atrial antitachycardia pacing therapies in patients suffering from sinus node disease and atrial fibrillation and implanted with a DDDRP device
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Giuseppe Boriani, Andrea Grammatico, Michele Massimo Gulizia, Ignazio Vaccaro, S. Mangiameli, Serafino Orazi, Giacomo Chiarandà, Guglielmo Piccione, Giuseppe Scardace, Calogero Puntrello, Calogero Vasco, Andrea Colletti, Gaetano Butera, Nicolò DiGiovanni, Gulizia M, Mangiameli S, Orazi S, Chiaranda G, Boriani G, Piccione G, DiGiovanni N, Colletti A, Puntrello C, Butera G, Vasco C, Vaccaro I, Scardace G, and Grammatico A
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Male ,Tachycardia ,law.invention ,Randomized controlled trial ,law ,Atrial Fibrillation ,80 and over ,Medicine ,Prospective Studies ,Sinus ,Aged, 80 and over ,education.field_of_study ,Cross-Over Studies ,Statistics ,Cardiac Pacing, Artificial ,Aged ,Arrhythmia, Sinus ,Chi-Square Distribution ,Female ,Humans ,Italy ,Least-Squares Analysis ,Middle Aged ,Quality of Life ,Statistics, Nonparametric ,Treatment Outcome ,Atrial fibrillation ,medicine.anatomical_structure ,Artificial ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Arrhythmia ,medicine.medical_specialty ,Population ,Physiology (medical) ,Internal medicine ,Nonparametric ,education ,Atrial tachycardia ,business.industry ,Sinoatrial node ,medicine.disease ,Antitachycardia Pacing ,Artificial cardiac pacemaker ,Cardiac Pacing ,business - Abstract
Atrial tachycardia and flutter frequently occur in association with atrial fibrillation and may be treated by overdrive pacing in patients who receive pacemakers with antitachycardia pacing (ATP) capabilities. The PITAGORA trial was a multi-centre, randomized, cross-over study aimed at comparing two different ATP modes for atrial tachyarrhythmia (AT) termination in patients suffering from sinus node disease (SND). METHODS AND RESULTS: One hundred and seventy-six patients (72 M, age 71+/-9 years) received a Medtronic AT500 pacemaker. All patients were on class IC or III antiarrhythmic drugs. After a 5-month observation period, 170 patients were randomized to either Ramp or Burst+ ATP therapy; 4 months later they crossed over. One hundred and fifty-seven patients completed the 13 months of follow-up; 114 (72.6%) suffered 6088 AT episodes. In 75 patients, 1904 AT episodes were treated and 934 (49.1%) successfully terminated. The median value of individual patients' ATP efficacy was 60%. Burst+ terminated 387 out of 873 AT episodes (44%) in 58 patients. Ramp terminated 547 out of 1031 AT episodes (53%, P240 ms. Quality of life, as measured by the EuroQoL questionnaire, and number of symptoms significantly improved in the overall population. This improvement was significantly higher in patients with ATP efficacy >60%. CONCLUSION: In patients suffering from SND and AT, Ramp therapy shows higher termination efficacy than Burst+ therapy in AT episodes with ATCL >240 ms. Further studies are required to show the impact of ATP on clinical outcomes.
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- 2006
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236. Predictors of Atrial Antitachycardia Pacing Efficacy in Patients Affected by Brady-Tachy Form of Sick Sinus Syndrome and Implanted with a DDDRP Device
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Michele Accogli, Andrea Grammatico, Giulio Molon, Giuseppe Boriani, Marco Vimercati, Michele Gulizia, Renato Ricci, Gianluca Botto, Alessandro Capucci, Massimo Santini, Alfredo Vicentini, Mauro Biffi, Luigi Padeletti, Boriani G, Padeletti L, Santini M, Gulizia M, Capucci A, Botto G, Ricci R, MolonG, Accogli M, Vicentini A, Biffi M, Vimercati M, and Grammatico A.
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Pacemaker, Artificial ,medicine.medical_specialty ,Nyha class ,Sick sinus syndrome ,Cohort Studies ,Predictive Value of Tests ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,In patient ,Sinus rhythm ,Prospective Studies ,Prospective cohort study ,Flecainide ,Aged ,Aged, 80 and over ,Sick Sinus Syndrome ,business.industry ,Anti-Arrhythmia Agents ,Middle Aged ,Multivariate Analysis ,Treatment Outcome ,Atrial fibrillation ,medicine.disease ,Antitachycardia Pacing ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Predictors of ATP Efficacy in Brady/Tachy Patients. Background: Recent options to treat atrial tachyarrhythmias (ATA) include implantable devices delivering antitachycardia pacing therapies (ATP). No prospective study selected patients with higher chances of episode termination by ATP or indicated the most effective ATP use. Our aim was to study ATP efficacy in patients with brady-tachy form of sinus node disease (SND), identifying clinical factors, ATA characteristics, and device features predicting ATP efficacy. Methods and Results: Three hundred and sixteen patients (105 M, aged 71.1 ′ 8.8 years) received a DDDRP pacemaker and were prospectively followed. Median follow-up was 18 months: 37,125 ATA episodes occurred in 217 patients; ATP treated 5,536 of them. Overall, ATP efficacy was 50.0%. A multivariate analysis identified longer arrhythmia cycle lengths (OR = 1.25; CI = 1.07-1.47) and shorter delays to ATP delivery (OR = 0.15; CI = 0.10-0.22) as independent predictors of ATP efficacy for episodes preceded by ≥5 minutes of sinus rhythm. Additionally, ATP efficacy for all treated episodes was predicted by lower New York Heart Association (NYHA) class (OR = 0.64; CI = 0.42-0.98), episode classification as nonimmediate recurrence of ATA (non-IRAT) (OR = 0.07; CI = 0.02-0.33), absence of overlap in the device detection windows (OR = 0.54; CI = 0.32-0.91), and flecainide treatment (OR = 2.22; CI = 1.04-4.71). Conclusions: In patients paced for SND, multivariate analysis shows that ATP efficacy is associated to longer arrhythmia cycle lengths, shorter ATP delivery delays, NYHA class I, episode classification as non-IRAT, absence of overlap in the atrial arrhythmia device detection windows, and flecainide treatment.
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- 2005
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237. A multidisciplinary consensus document on follow-up strategies for patients treated with percutaneous coronary intervention
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Roberta, Rossini, Luigi, Oltrona Visconti, Giuseppe, Musumeci, Alessandro, Filippi, Roberto, Pedretti, Corrado, Lettieri, Francesca, Buffoli, Marco, Campana, Davide, Capodanno, Battistina, Castiglioni, Maria Grazia, Cattaneo, Paola, Colombo, Leonardo, De Luca, Stefano, De Servi, Marco, Ferlini, Ugo, Limbruno, Daniele, Nassiacos, Emanuela, Piccaluga, Arturo, Raisaro, PierFranco, Ravizza, Michele, Senni, Erminio, Tabaglio, Giuseppe, Tarantini, Daniela, Trabattoni, Alessandro, Zadra, Carmine, Riccio, Francesco, Bedogni, Oreste, Febo, Ovidio, Brignoli, Roberto, Ceravolo, Gennaro, Sardella, Sante, Bongo, Pompilio, Faggiano, Claudio, Cricelli, Cesare, Greco, Michele Massimo, Gulizia, Sergio, Berti, Francesco, Bovenzi, Rossini, R, Visconti, L, Musumeci, G, Filippi, A, Pedretti, R, Lettieri, C, Buffoli, F, Campana, M, Capodanno, D, Castiglioni, B, Cattaneo, M, Colombo, P, De Luca, L, De Servi, S, Ferlini, M, Limbruno, U, Daniele, N, Piccaluga, E, Raisaro, A, Ravizza, P, Senni, M, Tabaglio, E, Tarantini, G, Trabattoni, D, Zadra, A, Riccio, C, Bedogni, F, Febo, O, Brignoli, O, Ceravolo, R, Sardella, G, Bongo, S, Faggiano, P, Cricelli, C, Greco, C, Gulizia, M, Berti, S, and Bovenzi, F
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Postoperative Care ,Consensus ,percutaneous coronary intervention ,Cardiology ,Coronary Artery Disease ,risk stratification ,Italy ,health care policy ,Follow-Up Studies ,Humans ,Percutaneous Coronary Intervention ,Practice Guidelines as Topic ,Societies, Medical ,Cardiology and Cardiovascular Medicine ,Radiology, Nuclear Medicine and Imaging ,Medical ,Nuclear Medicine and Imaging ,Societies ,Radiology - Abstract
The number of percutaneous coronary interventions (PCI) is increasing worldwide. Follow-up strategies after PCI are extremely heterogeneous and can greatly affect the cost of medical care. Of note, clinical evaluations and non-invasive exams are often performed to low risk patients. In the present consensus document, practical advises are provided with respect to a tailored follow-up strategy on the basis of patients' risk profile. Three strategies follow-up have been defined and types and timing of clinical and instrumental evaluations are reported. Clinical and interventional cardiologists, cardiac rehabilitators, and general practitioners, who are in charge to manage post-PCI patients, equally contributed to the creation of the present document.
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- 2014
238. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
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Giuseppe Boriani, Andreas Goette, Isabelle C. Van Gelder, Gerhard Steinbeck, Ursula Ravens, Carina Blomström-Lundqvist, Stephan Willems, Luis Mont, Paulus Kirchhof, Andreas Clemens, Nilo B. Cater, Robert Hatala, Axel Brandes, A. John Camm, Stefan Kääb, Jeroen J. Bax, Guenter Breithardt, Leif Friberg, Maria Borentain, Karl Wegscheider, Juergen Polifka, Dieter Paar, Michael Nabauer, Hein Heidbuchel, Michele Massimo Gulizia, Trudie Lobban, Ulrich Schotten, Josef Kautzner, Elaine M. Hylek, John M. Morgan, Wim Stegink, Lukas Szumowski, Paul Dorian, Jenny Horwood, Angelika Leute, Ralf Meyer, Alphons Vincent, Dobromir Dobrev, Deirdre A. Lane, Stefanie Breitenstein, Hans-Christoph Diener, Laurent M. Haegeli, Nils Edvardsson, Michael Oeff, Michael D. Ezekowitz, Lukas Kappenberger, Sergio Dubner, Gregory Y.H. Lip, Christoph Baertels, Panos E. Vardas, Martina Brueckmann, Maria Aunes-Jansson, Felix Muenzel, Maureen V Walter, Jay Millerhagen, Ludger Rosin, Kirchhof P, Lip GY, Van Gelder IC, Bax J, Hylek E, Kaab S, Schotten U, Wegscheider K, Boriani G, Brandes A, Ezekowitz M, Diener H, Haegeli L, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Aunes-Jansson M, Blomstrom-Lundqvist C, Borentain M, Breitenstein S, Brueckmann M, Cater N, Clemens A, Dobrev D, Dubner S, Edvardsson NG, Friberg L, Goette A, Gulizia M, Hatala R, Horwood J, Szumowski L, Kappenberger L, Kautzner J, Leute A, Lobban T, Meyer R, Millerhagen J, Morgan J, Muenzel F, Nabauer M, Baertels C, Oeff M, Paar D, Polifka J, Ravens U, Rosin L, Stegink W, Steinbeck G, Vardas P, Vincent A, Walter M, Breithardt G, Camm AJ., Fysiologie, and RS: CARIM School for Cardiovascular Diseases
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Male ,Heart disease ,Medizin ,antithrombotic therapy ,Management of atrial fibrillation ,outcomes ,GLOMERULAR-FILTRATION-RATE ,ATRIAL FIBRILLATION ,BIOLOGICAL MARKERS ,TREATMENT OUTCOME ,Antithrombotic ,Atrial Fibrillation ,RADIOFREQUENCY CATHETER ABLATION ,risk factors ,rhythm control ,early therapy ,CARDIOVASCULAR INTERVENTIONS EAPCI ,Atrial fibrillation ,C-REACTIVE PROTEIN ,VENTRICULAR SYSTOLIC DYSFUNCTION ,Treatment Outcome ,Female ,Cardiology and Cardiovascular Medicine ,Anti-Arrhythmia Agents ,management ,medicine.medical_specialty ,Long QT syndrome ,MEDLINE ,Reviews ,LONG-QT SYNDROME ,Early Therapy ,CARDIOLOGY WORKING GROUP ,CEREBRAL AMYLOID ANGIOPATHY ,Fibrinolytic Agents ,Physiology (medical) ,medicine ,Animals ,Humans ,STERILE PERICARDITIS MODEL ,Intensive care medicine ,LOBAR INTRACEREBRAL HEMORRHAGE ,rate control ,business.industry ,medicine.disease ,Rats ,business ,Risk Reduction Behavior ,Fibrinolytic agent ,Biomarkers - Abstract
While management of atrial fibrillation (AF) patients is improved by guideline-conform application of anticoagulant therapy, rate control, rhythm control, and therapy of accompanying heart disease, the morbidity and mortality associated with AF remain unacceptably high. This paper describes the proceedings of the 3rd Atrial Fibrillation NETwork (AFNET)/European Heart Rhythm Association (EHRA) consensus conference that convened over 60 scientists and representatives from industry to jointly discuss emerging therapeutic and diagnostic improvements to achieve better management of AF patients. The paper covers four chapters: (i) risk factors and risk markers for AF; (ii) pathophysiological classification of AF; (iii) relevance of monitored AF duration for AF-related outcomes; and (iv) perspectives and needs for implementing better antithrombotic therapy. Relevant published literature for each section is covered, and suggestions for the improvement of management in each area are put forward. Combined, the propositions formulate a perspective to implement comprehensive management in AF.
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- 2012
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239. Valsartan for prevention of recurrent atrial fibrillation
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GISSI AF Investigators, Disertori M, Latini R, Barlera S, Franzosi MG, Staszewsky L, Maggioni AP, Lucci D, Di Pasquale G, Tognoni G, Delise P, Bertocchi F, Maiocchi G, Geraci E, Correale E, Lombardi F, Mugelli A, Urso R, Scardi S, Fabbri G, Bartolomei B, Barbato G, Carbonieri E, Ciricugno S, Cosmi F, Pratola C, Rossi MG, Sciarra L, Zeni P, Ceseri M, Atzori A, Bambi F, Baviera M, Bianchini F, Fenicia E, Gianfriddo M, Lonardo G, Luise A, Nota R, Orlando ME, Petrolo R, Pierattini C, Pierota V, Ragno A, Serio C, Tafi A, Tellaroli E, Masson S, Vago T, Gramenzi S, Orso F, Suliman I, Nicolis E, Casola C, Dall'Osso D, Gorini M, Bianchini E, Cabiddu S, Cangioli I, Carnaghi A, Cipressa ML, Cipressa L, Galbiati L, Lorimer A, Priami P, Moccetti T, Vaghi F, Capello AF, Rossetti G, Viada E, Morena L, Delucchi M, Reynaud SG, Allemano P, Massobrio N, Gavazzi A, Taddei F, Mor DA, Bortolini F, Lorini M, Inama G, Durin O, Pirelli S, Spotti A, Procopio R, Cuzzucrea D, Gentile G, Margonato A, Bassanelli G, Tavazzi L, Buzzi MP, Rordorf R, Gualco A, Opasich C, Gronda E, Genovese L, Mattioli R, Donatelli F, Uriarte JA, Rauhe W, Bertagnolli C, Canestrini S, Stefenelli C, Cioffi G, Giovanelli C, Rigatelli G, Boni S, Pasini A, Sitta N, Sacchetta A, Borgese L, Sciascia R, Targa L, Raviele A, Madalosso M, Bertaglia E, Zoppo FC, Capanna M, Fiorencis R, Baracca E, Rossi R, Rossi I, Trappolin R, Morgera T, Barducci E, Baldin MG, Gobbo G, Zardo F, Hrovatin E, Mos L, Vriz O, Sinagra G, Aleksova A, Mazzone C, Fresco C, Rubartelli P, Moroni LA, Camerieri A, Piana M, Mureddu R, Bertoli D, Petacchi R, Pancaldi LG, Gabrieli L, Urbinati S, Pedone C, Di Niro M, Brunelli A, Bosi S, Censi S, Moruzzi P, Pastori P, Modena MG, Malavasi V, Mezzetti M, Melandri F, Zuppiroli A, Fazi A, Testa R, Venturini E, Mazzinghi F, Cosmi D, Santoro GM, Minneci C, Galli M, Paperini L, Bovenzi FM, Cortigiani L, Cocchieri M, Severini D, Arcuri GM, Bagliani G, Bernardinangeli M, Proietti G, Bocconcelli P, Pierantozzi A, Monti F, Giamundo L, Tancredi P, Rossini E, Bianchi C, Bettiol F, Giovannini E, Fera MS, Santini M, Bianconi L, Boccanelli A, Morosetti P, Volpe M, Facciolo C, Vacri A, Romanazzi F, Napoletano C, Piccioni LL, Candelmo F, De Marco G, Arnese MR, Vetrano A, Prinzi D, De Rosa P, Capuano V, Torre S, D'Onofrio A, Ammendola E, Battista R, De Fusco A, Molero U, Iervoglini A, Stefanelli S, Fattore L, Bosco B, Liguori A, Padula G, De Luca I, Sorino M, Colonna P, D'Agostino C, Pierfelice O, Pettinati G, Muscella A, De Lorenzi E, Falco M, Giannattasio C, Baldi N, Clemente MA, D'Alessandro B, Truncellito L, Arabia F, Ciconte VA, Perticone F, Ruberto C, Buffon A, Tomaselli C, De Rosa F, Mazza S, Zampaglione G, Pirozzi AM, Butera A, Levato M, Musacchio D, Polimeni RM, Lacquaniti V, Pulitanò G, Ruggeri A, Provenzano A, Cuccurullo O, Musolino M, Marrari A, Anastasio L, Schiavello M, Comito MG, Gulizia MM, Francese GM, Vasquez L, Coppolino C, Casale A, D'Urso G, Oliva G, Giordano U, Andolina S, Sanfilippo N, Ingrillì F, Accardo S, Grasso S, Buffa L, Serra E., CHIARIELLO, MASSIMO, PERRONE FILARDI, PASQUALE, Delise, P., Bertocchi, F., Maiocchi, G., Geraci, E., Correale, E., Lombardi, F., Mugelli, A., Urso, R., Scardi, S., Fabbri, G., Bartolomei, B., Barbato, G., Carbonieri, E., Ciricugno, S., Cosmi, F., Pratola, C., Rossi, M. G., Sciarra, L., Zeni, P., Ceseri, M., Atzori, A., Bambi, F., Baviera, M., Bianchini, F., Fenicia, E., Gianfriddo, M., Lonardo, G., Luise, A., Nota, R., Orlando, M. E., Petrolo, R., Pierattini, C., Pierota, V., Ragno, A., Serio, C., Tafi, A., Tellaroli, E., Masson, S., Vago, T., Gramenzi, S., Orso, F., Suliman, I., Nicolis, E., Casola, C., Dall'Osso, D., Gorini, M., Bianchini, E., Cabiddu, S., Cangioli, I., Carnaghi, A., Cipressa, M. L., Cipressa, L., Galbiati, L., Lorimer, A., Priami, P., Moccetti, T., Vaghi, F., Capello, A. F., Rossetti, G., Viada, E., Morena, L., Delucchi, M., Reynaud, S. G., Allemano, P., Massobrio, N., Gavazzi, A., Taddei, F., Mor, D. A., Bortolini, F., Lorini, M., Inama, G., Durin, O., Pirelli, S., Spotti, A., Procopio, R., Cuzzucrea, D., Gentile, G., Margonato, A., Bassanelli, G., Tavazzi, L., Buzzi, M. P., Rordorf, R., Gualco, A., Opasich, C., Gronda, E., Genovese, L., Mattioli, R., Donatelli, F., Uriarte, J. A., Rauhe, W., Bertagnolli, C., Canestrini, S., Stefenelli, C., Cioffi, G., Giovanelli, C., Rigatelli, G., Boni, S., Pasini, A., Sitta, N., Sacchetta, A., Borgese, L., Sciascia, R., Targa, L., Raviele, A., Madalosso, M., Bertaglia, E., Zoppo, F. C., Capanna, M., Fiorencis, R., Baracca, E., Rossi, R., Rossi, I., Trappolin, R., Morgera, T., Barducci, E., Baldin, M. G., Gobbo, G., Zardo, F., Hrovatin, E., Mos, L., Vriz, O., Sinagra, G., Aleksova, A., Mazzone, C., Fresco, C., Rubartelli, P., Moroni, L. A., Camerieri, A., Piana, M., Mureddu, R., Bertoli, D., Petacchi, R., Pancaldi, L. G., Gabrieli, L., Urbinati, S., Pedone, C., Di Niro, M., Brunelli, A., Bosi, S., Censi, S., Moruzzi, P., Pastori, P., Modena, M. G., Malavasi, V., Mezzetti, M., Melandri, F., Zuppiroli, A., Fazi, A., Testa, R., Venturini, E., Mazzinghi, F., Cosmi, D., Santoro, G. M., Minneci, C., Galli, M., Paperini, L., Bovenzi, F. M., Cortigiani, L., Cocchieri, M., Severini, D., Arcuri, G. M., Bagliani, G., Bernardinangeli, M., Proietti, G., Bocconcelli, P., Pierantozzi, A., Monti, F., Giamundo, L., Tancredi, P., Rossini, E., Bianchi, C., Bettiol, F., Giovannini, E., Fera, M. S., Santini, M., Bianconi, L., Boccanelli, A., Morosetti, P., Volpe, M., Facciolo, C., Vacri, A., Romanazzi, F., Napoletano, C., Piccioni, L. L., Candelmo, F., De Marco, G., Arnese, M. R., Vetrano, A., Prinzi, D., De Rosa, P., Capuano, V., Torre, S., D'Onofrio, A., Ammendola, E., Chiariello, M., Filardi, Pp., Battista, R., De Fusco, A., Molero, U., Iervoglini, A., Stefanelli, S., Fattore, L., Bosco, B., Liguori, A., Padula, G., De Luca, I., Sorino, M., Colonna, P., D'Agostino, C., Pierfelice, O., Pettinati, G., Muscella, A., De Lorenzi, E., Falco, M., Giannattasio, C., Baldi, N., Clemente, M. A., D'Alessandro, B., Truncellito, L., Arabia, F., Ciconte, V. A., Perticone, F., Ruberto, C., Buffon, A., Tomaselli, C., De Rosa, F., Mazza, S., Zampaglione, G., Pirozzi, A. M., Butera, A., Levato, M., Musacchio, D., Polimeni, R. M., Lacquaniti, V., Pulitano, G., Ruggeri, A., Provenzano, A., Cuccurullo, O., Musolino, M., Marrari, A., Anastasio, L., Schiavello, M., Comito, M. G., Gulizia, M. M., Francese, G. M., Vasquez, L., Coppolino, C., Casale, A., D'Urso, G., Oliva, G., Giordano, U., Andolina, S., Sanfilippo, N., Ingrilli, F., Accardo, S., Grasso, S., Buffa, L., Serra, E., Disertori, Marcello, Latini, Roberto, Barlera, Simona, Franzosi, Maria Grazia, Staszewsky, Lidia, Maggioni, Aldo Pietro, Lucci, Donata, Di Pasquale, Giuseppe, Tognoni, Gianni, GISSI AF, Investigator, Disertori, M, Latini, R, Barlera, S, Franzosi, Mg, Staszewsky, L, Maggioni, Ap, Lucci, D, Di Pasquale, G, Tognoni, G, Delise, P, Bertocchi, F, Maiocchi, G, Geraci, E, Correale, E, Lombardi, F, Mugelli, A, Urso, R, Scardi, S, Fabbri, G, Bartolomei, B, Barbato, G, Carbonieri, E, Ciricugno, S, Cosmi, F, Pratola, C, Rossi, Mg, Sciarra, L, Zeni, P, Ceseri, M, Atzori, A, Bambi, F, Baviera, M, Bianchini, F, Fenicia, E, Gianfriddo, M, Lonardo, G, Luise, A, Nota, R, Orlando, Me, Petrolo, R, Pierattini, C, Pierota, V, Ragno, A, Serio, C, Tafi, A, Tellaroli, E, Masson, S, Vago, T, Gramenzi, S, Orso, F, Suliman, I, Nicolis, E, Casola, C, Dall'Osso, D, Gorini, M, Bianchini, E, Cabiddu, S, Cangioli, I, Carnaghi, A, Cipressa, Ml, Cipressa, L, Galbiati, L, Lorimer, A, Priami, P, Moccetti, T, Vaghi, F, Capello, Af, Rossetti, G, Viada, E, Morena, L, Delucchi, M, Reynaud, Sg, Allemano, P, Massobrio, N, Gavazzi, A, Taddei, F, Mor, Da, Bortolini, F, Lorini, M, Inama, G, Durin, O, Pirelli, S, Spotti, A, Procopio, R, Cuzzucrea, D, Gentile, G, Margonato, A, Bassanelli, G, Tavazzi, L, Buzzi, Mp, Rordorf, R, Gualco, A, Opasich, C, Gronda, E, Genovese, L, Mattioli, R, Donatelli, F, Uriarte, Ja, Rauhe, W, Bertagnolli, C, Canestrini, S, Stefenelli, C, Cioffi, G, Giovanelli, C, Rigatelli, G, Boni, S, Pasini, A, Sitta, N, Sacchetta, A, Borgese, L, Sciascia, R, Targa, L, Raviele, A, Madalosso, M, Bertaglia, E, Zoppo, Fc, Capanna, M, Fiorencis, R, Baracca, E, Rossi, R, Rossi, I, Trappolin, R, Morgera, T, Barducci, E, Baldin, Mg, Gobbo, G, Zardo, F, Hrovatin, E, Mos, L, Vriz, O, Sinagra, G, Aleksova, A, Mazzone, C, Fresco, C, Rubartelli, P, Moroni, La, Camerieri, A, Piana, M, Mureddu, R, Bertoli, D, Petacchi, R, Pancaldi, Lg, Gabrieli, L, Urbinati, S, Pedone, C, Di Niro, M, Brunelli, A, Bosi, S, Censi, S, Moruzzi, P, Pastori, P, Modena, Mg, Malavasi, V, Mezzetti, M, Melandri, F, Zuppiroli, A, Fazi, A, Testa, R, Venturini, E, Mazzinghi, F, Cosmi, D, Santoro, Gm, Minneci, C, Galli, M, Paperini, L, Bovenzi, Fm, Cortigiani, L, Cocchieri, M, Severini, D, Arcuri, Gm, Bagliani, G, Bernardinangeli, M, Proietti, G, Bocconcelli, P, Pierantozzi, A, Monti, F, Giamundo, L, Tancredi, P, Rossini, E, Bianchi, C, Bettiol, F, Giovannini, E, Fera, M, Santini, M, Bianconi, L, Boccanelli, A, Morosetti, P, Volpe, M, Facciolo, C, Vacri, A, Romanazzi, F, Napoletano, C, Piccioni, Ll, Candelmo, F, De Marco, G, Arnese, Mr, Vetrano, A, Prinzi, D, De Rosa, P, Capuano, V, Torre, S, D'Onofrio, A, Ammendola, E, Chiariello, Massimo, PERRONE FILARDI, Pasquale, Battista, R, De Fusco, A, Molero, U, Iervoglini, A, Stefanelli, S, Fattore, L, Bosco, B, Liguori, A, Padula, G, De Luca, I, Sorino, M, Colonna, P, D'Agostino, C, Pierfelice, O, Pettinati, G, Muscella, A, De Lorenzi, E, Falco, M, Giannattasio, C, Baldi, N, Clemente, Ma, D'Alessandro, B, Truncellito, L, Arabia, F, Ciconte, Va, Perticone, F, Ruberto, C, Buffon, A, Tomaselli, C, De Rosa, F, Mazza, S, Zampaglione, G, Pirozzi, Am, Butera, A, Levato, M, Musacchio, D, Polimeni, Rm, Lacquaniti, V, Pulitanò, G, Ruggeri, A, Provenzano, A, Cuccurullo, O, Musolino, M, Marrari, A, Anastasio, L, Schiavello, M, Comito, Mg, Gulizia, Mm, Francese, Gm, Vasquez, L, Coppolino, C, Casale, A, D'Urso, G, Oliva, G, Giordano, U, Andolina, S, Sanfilippo, N, Ingrillì, F, Accardo, S, Grasso, S, and Buffa, L
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Tetrazoles ,Cardiomegaly ,Comorbidity ,Placebo ,Cardioversion ,Double-Blind Method ,Recurrence ,Multicenter trial ,Internal medicine ,Angiotensin II Type 1 Receptor Blocker ,Cardiovascular Disease ,Atrial Fibrillation ,medicine ,Left atrial enlargement ,Diabetes Mellitus ,Humans ,Sinus rhythm ,cardiovascular diseases ,Prospective Studies ,Tetrazole ,Proportional Hazards Models ,Aged ,business.industry ,Medicine (all) ,Hazard ratio ,Atrial fibrillation ,Diabetes Mellitu ,Valine ,General Medicine ,Middle Aged ,medicine.disease ,valsartan ,atrial fibrillation ,Prospective Studie ,Valsartan ,Cardiovascular Diseases ,cardiovascular system ,Cardiology ,Proportional Hazards Model ,Female ,business ,Angiotensin II Type 1 Receptor Blockers ,medicine.drug ,Human - Abstract
BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia, and no current therapy is ideal for control of this condition. Experimental studies suggest that angiotensin II-receptor blockers (ARBs) can influence atrial remodeling, and some clinical studies suggest that they may prevent atrial fibrillation. METHODS: We conducted a large, randomized, prospective, placebo-controlled, multicenter trial to test whether the ARB valsartan could reduce the recurrence of atrial fibrillation. We enrolled patients who were in sinus rhythm but had had either two or more documented episodes of atrial fibrillation in the previous 6 months or successful cardioversion for atrial fibrillation in the previous 2 weeks. To be eligible, patients also had to have underlying cardiovascular disease, diabetes, or left atrial enlargement. Patients were randomly assigned to receive valsartan or placebo. The two primary end points were the time to a first recurrence of atrial fibrillation and the proportion of patients who had more than one recurrence of atrial fibrillation over the course of 1 year. RESULTS: A total of 1442 patients were enrolled in the study. Atrial fibrillation recurred in 371 of the 722 patients (51.4%) in the valsartan group, as compared with 375 of 720 (52.1%) in the placebo group (adjusted hazard ratio, 0.97; 96% confidence interval [CI], 0.83 to 1.14; P = 0.73). More than one episode of atrial fibrillation occurred in 194 of 722 patients (26.9%) in the valsartan group and in 201 of 720 (27.9%) in the placebo group (adjusted odds ratio, 0.89; 99% CI, 0.64 to 1.23; P = 0.34). The results were similar in all predefined subgroups of patients, including those who were not receiving angiotensin-converting-enzyme inhibitors. CONCLUSIONS: Treatment with valsartan was not associated with a reduction in the incidence of recurrent atrial fibrillation. (ClinicalTrials.gov number, NCT00376272.) Copyright © 2009 Massachusetts Medical Society.
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- 2009
240. A randomized comparison of amiodarone and class IC antiarrhythmic drugs to treat atrial fibrillation in patients paced for sinus node disease: the Prevention Investigation and Treatment: A Group for Observation and Research on Atrial arrhythmias (PITAGORA) trial
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Francesco Lisi, Giuseppe Boriani, Andrea Grammatico, S. Mangiameli, Nicolò Di Giovanni, Ludovico Vasquez, Michele Massimo Gulizia, Serafino Orazi, Giacomo Chiarandà, Guglielmo Piccione, Orazio Pensabene, Andrea Colletti, Gulizia M, Mangiameli S, Orazi S, Chiarandà G, Piccione G, Di Giovanni N, Colletti A, Pensabene O, Lisi F, Vasquez L, Grammatico A, and Boriani G
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Male ,medicine.medical_treatment ,Amiodarone ,Propafenone ,law.invention ,Electrocardiography ,Randomized controlled trial ,law ,Reference Values ,Atrial Fibrillation ,80 and over ,Single-Blind Method ,Prospective Studies ,Sinus ,Aged, 80 and over ,Flecainide ,medicine.diagnostic_test ,Sotalol ,Statistics ,Cardiac Pacing, Artificial ,Aged ,Anti-Arrhythmia Agents ,Arrhythmia, Sinus ,Dose-Response Relationship, Drug ,Drug Administration Schedule ,Drug Therapy, Combination ,Female ,Follow-Up Studies ,Humans ,Probability ,Risk Assessment ,Statistics, Nonparametric ,Survival Rate ,Treatment Outcome ,Atrial fibrillation ,Anesthesia ,Artificial ,Combination ,Cardiology ,Drug ,Cardiology and Cardiovascular Medicine ,Arrhythmia ,medicine.drug ,medicine.medical_specialty ,Randomization ,Antiarrhythmic agent ,Dose-Response Relationship ,Drug Therapy ,Internal medicine ,medicine ,Nonparametric ,business.industry ,medicine.disease ,Cardiac Pacing ,business - Abstract
BACKGROUND: Rhythm control is an important goal in the treatment of recurrent atrial tachyarrhythmias (AT). The PITAGORA study was a randomized trial in patients paced for sinus node disease (SND), designed to test the noninferiority of class IC antiarrhythmic drugs (AADs) to amiodarone in terms of a primary end point composed of death, permanent AT, cardiovascular hospitalization, atrial cardioversion, or AAD change. METHODS: Randomization was stratified to assign 2 patients to amiodarone and 2 patients to class IC AADs: propafenone or flecainide. One hundred seventy-six patients (46% men, 72 +/- 8 years) were enrolled. Device diagnostics continuously monitored AT recurrences and duration. RESULTS: In a mean follow-up of 20 +/- 9 months, the primary end point occurred in 23 (30.7%) of 75 class IC patients and in 28 (40.0%) of 70 amiodarone patients. The absolute difference in the end point incidence (-9.3%; 95% CI between 3.7% and -22.3%) confirmed the noninferiority of class IC to amiodarone (P = .007). Kaplan-Meier 1-year freedom from AT episodes >10 minutes, 1 day, and 7 days was 40%, 73%, and 91% for amiodarone and 28%, 78%, and 86% for class IC AADs (P = nonsignificant). CONCLUSIONS: In patients paced for SND and suffering from AT, class IC AADs proved not to be inferior to amiodarone in terms of the primary composite end point described or end points which were differently composed of mortality, efficacy, or AAD side effects. The AADs studied also showed similar results in terms of symptoms, quality of life, and freedom from AT recurrences.
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- 2008
241. Rate control in patients with pacemaker affected by brady-tachy form of sick sinus syndrome
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Serafino Orazi, Michele Massimo Gulizia, Gianluca Botto, Paola DiStefano, Marco Vimercati, Giuseppe Boriani, Andrea Grammatico, Mauro Biffi, Alessandro Capucci, Cristian Martignani, Luigi Padeletti, Massimo Santini, Renato Pietro Ricci, Boriani G, Padeletti L, Santini M, Gulizia M, Orazi S, Botto G, Capucci A, Biffi M, Martignani C, Ricci R, Vimercati M, DiStefano P, and Grammatico A.
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Bradycardia ,Male ,medicine.medical_specialty ,Pacemaker, Artificial ,Digoxin ,Adrenergic beta-Antagonists ,Amiodarone ,Sick sinus syndrome ,Electrocardiography ,Heart Rate ,Internal medicine ,Heart rate ,Ambulatory ,medicine ,Humans ,Survival rate ,Aged ,Sick Sinus Syndrome ,medicine.diagnostic_test ,business.industry ,Sotalol ,Cardiac Pacing, Artificial ,medicine.disease ,Surgery ,Defibrillators, Implantable ,Pacemaker ,Survival Rate ,Artificial ,Cardiology ,Electrocardiography, Ambulatory ,Cardiac Pacing ,Female ,medicine.symptom ,Implantable ,Cardiology and Cardiovascular Medicine ,business ,Anti-Arrhythmia Agents ,medicine.drug ,Defibrillators - Abstract
Background In sinus node disease (SND) atrial tachyarrhythmias (ATs) may frequently occur, after implant of a pacemaker for bradycardia, and are to be managed by rate or rhythm control. Methods We evaluated ventricular heart rate (HR) during AT, AT-related symptoms and hospitalizations in 333 patients who received DDDRP pacemakers for SND. Results In days with 24 hours of AT, mean daily HR during AT was >80, 90, 100, 110, and 120 beats per minute (bpm) in 191 (57%), 114 (34%), 55 (16%), 23 (7%), and 11 (3%) patients, respectively. The proportion of patients with a mean daily HR >80 bpm during AT despite the use of rate control agents was 28% among patients treated with calcium-channel blockers, 43% with digoxin, 49% with a combination of agents, 54% with amiodarone, 64% with sotalol, and 69% with β blockers. Patients with HR >100 bpm experienced a higher prevalence of both AT-related hospitalizations and cardiovascular hospitalizations than those with HR ≤100 bpm (36% vs 21%, P = .013; 42% vs 28%, P = .003) and a significantly higher number of AT-related symptoms (1.8 ± 0.9 vs 1.4 ± 1.0, P = .008). Conclusions Limited attention has been dedicated to rate control in patients with pacemaker. This is the first study to evaluate the prevalence and implications of inappropriate rate control in patients with pacemaker. We found that in a substantial proportion of patients with SND who have recurrent ATs despite pacing, mean daily HR during AT is high and that these patients present increased hospitalizations and more symptoms, thus suggesting the need to improve rate control.
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- 2007
242. Duration of P-wave is associated with atrial fibrillation hospitalizations in patients with atrial fibrillation and paced for bradycardia
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Andrea Spampinato, Andrea Grammatico, Luigi Padeletti, Giuseppe Vergara, Massimo Santini, Pyotr Platonov, Paolo Pieragnoli, S. Serge Barold, Werner G Rahue, Michele Gulizia, Alessandro Capucci, Renato Ricci, Gianluca Botto, Giuseppe Boriani, Padeletti L, Santini M, Boriani G, Botto G, Ricci R, Spampinato A, Vergara G, Rahue WG, Capucci A, Gulizia M, Pieragnoli P, Grammatico A, Platonov P, and Barold SS.
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Male ,Bradycardia ,Pacemaker, Artificial ,medicine.medical_specialty ,medicine.medical_treatment ,Cardioversion ,Aged ,Atrial Fibrillation ,Cardiac Pacing, Artificial ,Chi-Square Distribution ,Female ,Follow-Up Studies ,Hospitalization ,Humans ,Logistic Models ,Predictive Value of Tests ,Prospective Studies ,Recurrence ,Treatment Outcome ,Interquartile range ,Internal medicine ,medicine ,Prospective cohort study ,Fibrillation ,business.industry ,Atrial fibrillation ,General Medicine ,medicine.disease ,Pacemaker ,Predictive value of tests ,Artificial ,Cardiology ,Cardiac Pacing ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Cardioversions ,business - Abstract
Atrial fibrillation (AF) is a common problem in pacemaker patients. We conducted a prospective observational study in patients paced for bradycardia with associated paroxysmal or persistent AF, to determine whether P-wave duration may stratify patients at higher risk for AF recurrences and AF-related hospitalizations. The patients were evaluated for the prevalence, cause, and predictors of hospitalization.We studied 660 consecutive patients (50% male, 72 +/- 9 years) who received a dual-chamber pacemaker. Median value of baseline P-wave duration was equal to 100 ms (25%-75% quartile range equal to 80-120 ms). We used this cut-off to divide the patients into group A (Por = 100 ms), composed of 385 (58.3%) patients, and group B (P100 ms), composed of 275 (41.7%) patients.In a median follow-up of 19 months, 173 patients were hospitalized for all causes, 130 for cardiovascular causes, and 85 for AF-related hospitalizations. Multivariate logistic analysis showed that P-wave duration100 ms identified patients at higher risk (OR = 1.6, 95% confidence interval (1.1-2.8), P = 0.044) for AF-related hospitalizations. Patients in group B (P100 ms) more frequently suffered AF-related hospitalizations (16.4% vs 10.4%, P = 0.02) and underwent more frequent cardioversions (14.5% vs 9.1%, P = 0.029) compared with group A (Por = 100 ms).P-wave duration may define the risk of persistent AF requiring cardioversion or AF-related hospitalization in patients with a pacemaker for bradycardia with associated paroxysmal or persistent AF.
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- 2007
243. Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers
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F. Zolezzi, Massimo Santini, Luigi Padeletti, Stefano Favale, Fabrizio Drago, Giulio Molon, Elena Mazzini, Italian At Registry Investigators, Giuseppe Boriani, Andrea Grammatico, Renato Pietro Ricci, Giovanni Quinto Villani, Natale Di Belardino, Michele Massimo Gulizia, Gianluca Botto, Marco Vimercati, Alessandro Capucci, Capucci A, Santini M, Padeletti L, Gulizia M, Botto G, Boriani G, Ricci R, Favale S, Zolezzi F, Di Belardino N, Molon G, Drago F, Villani GQ, Mazzini E, Vimercati M, and Grammatico A
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Bradycardia ,Male ,medicine.medical_specialty ,Pacemaker, Artificial ,Arterial embolism ,Time Factors ,Heart disease ,Embolism ,Aged ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Monitoring, Physiologic ,Prospective Studies ,Risk Factors ,Interquartile range ,Internal medicine ,medicine ,Prospective cohort study ,business.industry ,Atrial fibrillation ,Odds ratio ,medicine.disease ,Anesthesia ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives The aim of our study was to evaluate arterial embolism (AE) occurrence rates and predictors in patients suffering from bradycardia and wearing a pacemaker with antitachycardia pacing therapies. Background Atrial fibrillation (AF) is associated with a high incidence of AE. Methods A total of 725 patients (360 men, age 71 ± 11 years) were implanted with a DDDRP pacemaker (Medtronic AT500, Medtronic Inc., Minneapolis, Minnesota). At baseline 225 (31.0%) patients received antiplatelet therapy and 264 (36.4%) patients received anticoagulation agents. Results Over a median 22-month follow-up (25th to 75th interquartile range 16 to 30 months), AE occurred in 14 (1.9%) patients: 7 patients suffered a nonfatal ischemic stroke (0.6% per year), 4 patients had transient ischemic attack (0.34% per year), and 3 patients had embolic complications. Among baseline patients’ characteristics, multivariate logistic analysis showed that embolic events are independently associated to ischemic heart disease (7.0 odds ratio [OR], 95% confidence interval [CI] 2.3 to 21.3, p = 0.001), prior embolic event (7.3 OR, 95% CI 1.2 to 43.9, p = 0.029), diabetes (5.0 OR, 95% CI 1.2 to 15.7, p = 0.032), and hypertension (4.1 OR, 95% CI 1.1 to 15.6, p = 0.036). The risk of embolism, adjusted for known risk factors, was 3.1 times increased (95% CI 1.1 to 10.5, p = 0.044) in patients with device-detected atrial fibrillation episodes longer than one day during follow-up. Conclusions In a cohort of patients with bradycardia and AF, arterial embolism was common in patients with ischemic cardiopathy, hypertension, diabetes mellitus, and in patients with known stroke risk factors. Atrial fibrillation occurrences longer than one day were independently associated with embolic events.
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- 2006
244. Temporal variability of atrial tachyarrhythmia burden in bradycardia-tachycardia syndrome patients
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Massimo Santini, Alessandro Capucci, Giuseppe Boriani, Andrea Grammatico, Renato Pietro Ricci, Paolo Pieragnoli, Marco Vimercati, Andrea Spampinato, Luigi Padeletti, Gianluca Botto, Eduardo N. Warman, Michele Massimo Gulizia, Padeletti L, Santini M, Boriani G, Botto G, Capucci A, Gulizia M, Ricci R, Spampinato A, Pieragnoli P, Warman E, Vimercati M, and Grammatico A.
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Bradycardia ,Male ,Pacemaker, Artificial ,Heart disease ,Disease ,Aged ,Cost of Illness ,Cross-Over Studies ,Female ,Humans ,Recurrence ,Sample Size ,Syndrome ,Tachycardia ,Medicine ,Atrial tachycardia ,Dual Chamber Pacemaker ,business.industry ,Atrial fibrillation ,medicine.disease ,Crossover study ,Pacemaker ,Sample size determination ,Anesthesia ,Artificial ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Several studies have tested non-pharmacological therapies for atrial tachyarrhythmias (ATs) by measuring the cumulative time (burden) the patient spends in arrhythmia. Contradictory results questioned either therapy efficacy or statistical power of the trials. We studied AT burden variability in patients paced for sinus node disease (SND) in order to interpret currently published data appropriately and to evaluate reliable sample sizes. METHODS AND RESULTS: One hundred and five patients with AT and SND received a dual chamber pacemaker with antitachyarrhythmia-pacing capability, and were followed for 13 months. Seventy-eight patients (74%) suffered AT recurrences. Device-gathered diagnostic measures were used to simulate results of randomized studies both with crossover and parallel design. The sample size required for statistically significant results was calculated as a function of the expected therapy-induced burden reduction. AT burden intra-patient variability was high: 43% of patients showed intrinsic fluctuations hiding any therapy-induced burden reduction lower than 30%. Demonstrating therapeutic breakthrough through a 6 month study would require 290 patients with crossover design and 5800 patients with parallel design. Doubling the study period requires 400 and 3000 patients, respectively. CONCLUSION: Patients with AT and paced for SND showed high intra-patient burden variability, which could possibly hide an AT burden reduction induced by a therapy. Previous studies involving non-pharmacological therapies utilizing AT burden endpoints could lack the power to reach statistical significance.
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- 2005
245. A randomised comparison between Ramp and Burst+ atrial antytachycardia pacing therapies in patients suffering from bradycardia and atrial fibrillation and implanted with a DDDRP device
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BORIANI, GIUSEPPE, O. Pensabene, S. Mangiameli, N. Di Giovanni, A. Colletti, C. Puntrello, G. Scardace, M. Gulizia, Gulizia M, Mangiameli S, Orazi S, Chiaranda’ G, Boriani G, Piccione G, Puntrello C, Scardace G, G. Boriani, O. Pensabene, S. Mangiameli, N. Di Giovanni, A. Colletti, C. Puntrello, G. Scardace, and M. Gulizia
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- 2005
246. Adjustments of iodinated contrast media using lean body weight for abdominopelvic computed tomography: A systematic review and meta-analysis.
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Gulizia M, Ding S, Sá Dos Reis C, Jaques C, and Dromain C
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- Humans, Pelvis diagnostic imaging, Radiography, Abdominal methods, Body Weight, Contrast Media administration & dosage, Tomography, X-Ray Computed methods
- Abstract
Purpose: This systematic review aimed to compare the effect of contrast media (CM) dose adjustment based on lean body weight (LBW) method versus other calculation protocols for abdominopelvic CT examinations., Method: Studies published from 2002 onwards were systematically searched in June 2024 across Medline, Embase, CINAHL, Cochrane CENTRAL, Web of Science, Google Scholar and four other grey literature sources, with no language limit. Randomised controlled trials (RCT) and quasi-RCT of abdominopelvic or abdominal CT examinations in adults with contrast media injection for oncological and acute diseases were included. The comparators were other contrast dose calculation methods such as total body weight (TBW), fixed volume (FV), body surface area (BSA), and blood volume. The main outcomes considered were liver and aortic enhancement. Titles, abstracts and full texts were independently screened by two reviewers., Results: Eight studies were included from a total of 2029 articles identified. Liver parenchyma and aorta contrast enhancement did not significantly differ between LBW and TBW protocols (p = 0.07, p = 0.06, respectively). However, the meta-analysis revealed significantly lower contrast volume injected with LBW protocol when compared to TBW protocol (p = 0.003). No statistical differences were found for contrast enhancement and contrast volume between LBW and the other strategies., Conclusion: Calculation of the CM dosage based on LBW allows a reduction in the injected volume for abdominopelvic CT examination, ensuring the same image quality in terms of contrast enhancement., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2024
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247. Gated cardiac CT in infants: What can we expect from deep learning image reconstruction algorithm?
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Gulizia M, Alamo L, Alemán-Gómez Y, Cherpillod T, Mandralis K, Chevallier C, Tenisch E, and Viry A
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- Humans, Infant, Reproducibility of Results, Electrocardiography, Coronary Angiography methods, Computed Tomography Angiography, Age Factors, Deep Learning, Phantoms, Imaging, Radiographic Image Interpretation, Computer-Assisted, Radiation Dosage, Predictive Value of Tests, Cardiac-Gated Imaging Techniques, Radiation Exposure prevention & control, Heart Defects, Congenital diagnostic imaging
- Abstract
Background: ECG-gated cardiac CT is now widely used in infants with congenital heart disease (CHD). Deep Learning Image Reconstruction (DLIR) could improve image quality while minimizing the radiation dose., Objectives: To define the potential dose reduction using DLIR with an anthropomorphic phantom., Method: An anthropomorphic pediatric phantom was scanned with an ECG-gated cardiac CT at four dose levels. Images were reconstructed with an iterative and a deep-learning reconstruction algorithm (ASIR-V and DLIR). Detectability of high-contrast vessels were computed using a mathematical observer. Discrimination between two vessels was assessed by measuring the CT spatial resolution. The potential dose reduction while keeping a similar level of image quality was assessed., Results: DLIR-H enhances detectability by 2.4% and discrimination performances by 20.9% in comparison with ASIR-V 50. To maintain a similar level of detection, the dose could be reduced by 64% using high-strength DLIR in comparison with ASIR-V50., Conclusion: DLIR offers the potential for a substantial dose reduction while preserving image quality compared to ASIR-V., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to disclose. All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report. We certify that the submission is original work and is not under review at any other publication. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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248. Plain radiography has a role to play in current clinical practice in Western Switzerland.
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Sá Dos Reis C, Gulizia M, Champendal M, De Labouchere S, Sun Z, and Silva C
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- Humans, Switzerland, Radiography, Software, Radiology education
- Abstract
Aim: The aim of the study was to investigate the current role of conventional radiography examinations in Western Switzerland and the main clinical indications required to justify the use of this imaging examination., Methods: Ethical approval was obtained from Vaud Ethics committee (Ref 2020-00311). An online questionnaire was specifically designed and implemented on the data collection tool LimeSurvey composed of two parts: a) to characterise the participants' profile and their institutions and b) 169 projections for the different anatomical area (upper and lower limbs, pelvis, skull, spine, thorax, abdomen) were presented to collect data about the frequency and main clinical indications. Statistical analysis was performed using the software IBM SPSS® (Statistical Package for the Social Sciences) version 26., Results: Radiographers from 60% (26/43) of the invited institutions participated in this survey, mainly from Vaud region. The upper and lower limbs were the most commonly examined by using conventional radiography mainly for trauma and degenerative disorders. The thorax was also an anatomical area commonly explored by X-rays, so were the spine (cervical and lumbar lateral). The skull radiographs were rarely performed in clinical practice and some of the projections were not being used, namely Hirtz, Tangential Nose Bones, Worms and Caldwell's views., Conclusions: Plain radiography is being used in clinical practice mainly for appendicular skeleton studies and for trauma and degenerative pathologies. Adaptations in radiographers' education and training and other healthcare professionals are needed to provide the judicious use of data that radiographs can give to better manage the patients' imaging pathway., (Copyright © 2023. Published by Elsevier Inc.)
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- 2023
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249. The combination of non-contrast abbreviated MRI and alpha foetoprotein has high performance for hepatocellular carcinoma screening.
- Author
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Girardet R, Dubois M, Manasseh G, Jreige M, Du Pasquier C, Canniff E, Gulizia M, Bonvin M, Aleman Y, Taouli B, Fraga M, Dromain C, and Vietti Violi N
- Subjects
- Humans, Middle Aged, Retrospective Studies, alpha-Fetoproteins, Gadolinium DTPA, Magnetic Resonance Imaging methods, Contrast Media pharmacology, Sensitivity and Specificity, Carcinoma, Hepatocellular diagnostic imaging, Liver Neoplasms diagnostic imaging
- Abstract
Objectives: This study aimed to compare two abbreviated MRI (AMRI) protocols to complete MRI for HCC detection: non-contrast (NC)-AMRI without/with alpha foetoprotein (AFP) and dynamic contrast-enhanced (Dyn)-AMRI., Methods: This retrospective single-center study included 351 patients (M/F: 264/87, mean age: 57y) with chronic liver disease, who underwent MRI for HCC surveillance between 2014 and 2020. Two reconstructed AMRI sets were obtained based on complete MRI: NC-AMRI (T2-weighted imaging (WI) + diffusion-WI) and Dyn-AMRI (T2-WI + dynamic T1-WI) and were assessed by 2 radiologists who reported all suspicious lesions, using LI-RADS/adapted LI-RADS classification. The reference standard was based on all available patient data. Inter-reader agreement was assessed and MRI diagnostic performance was compared to the reference standard., Results: The reference standard demonstrated 83/351 HCC-positive patients (prevalence: 23.6%, median size: 22 mm, and positive MRIs: 83/631). Inter-reader agreement was substantial for all sets. Sensitivities of Dyn-AMRI and complete MRI (both 92.8%) were similar, higher than NC-AMRI (72.3%, p < 0.001). Specificities were not different between sets. NC-AMRI + AFP (92.8%) had similar sensitivity to Dyn-AMRI and complete MRI. In patients with small size HCCs (≤ 2 cm), sensitivities of Dyn-AMRI (85.3%) and complete MRI (88.2%) remained similar (p = 0.564), also outperforming NC-AMRI (52.9%, p < 0.05). NC-AMRI + AFP had similar sensitivity (88.2%) to Dyn-AMRI and complete MRI (p = 0.706 and p = 1, respectively)., Conclusions: Dyn-AMRI has similar diagnostic performance to complete MRI for HCC detection, while both outperform NC-AMRI, especially for small size HCCs. NC-AMRI + AFP demonstrates similar sensitivity to Dyn-AMRI and complete MRI., Clinical Relevance Statement: Due to the low sensitivity of ultrasound for hepatocellular screening, new screening methods are needed. Abbreviated MRI (AMRI) is a candidate, especially non-contrast AMRI with serum alpha foetoprotein as the acquisition time is low, without the need for contrast medium injection., Key Points: • Dynamic contrast-enhanced abbreviated MRI using extracellular gadolinium-based contrast agent and complete MRI have similar diagnostic performance for hepatocellular carcinoma detection in an at-risk population. • Non-contrast abbreviated MRI with alpha foetoprotein has similar diagnostic performance to dynamic contrast-enhanced abbreviated MRI and complete MRI, including when considering small size hepatocellular carcinoma ≤ 2 cm. • Non-contrast abbreviated MRI and dynamic contrast-enhanced abbreviated MRI can be performed in 7 and 10 min, excluding patient setup time., (© 2023. The Author(s).)
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- 2023
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250. Avoiding unnecessary ventricular pacing is associated with reduced incidence of heart failure hospitalizations and persistent atrial fibrillation in pacemaker patients.
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Arnold M, Richards M, D'Onofrio A, Faulknier B, Gulizia M, Thakur R, Sakata Y, Lin W, Pollastrelli A, Grammatico A, Auricchio A, and Boriani G
- Subjects
- Humans, Female, Male, Cardiac Pacing, Artificial methods, Incidence, Treatment Outcome, Sick Sinus Syndrome therapy, Hospitalization, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Atrial Fibrillation prevention & control, Pacemaker, Artificial adverse effects, Heart Failure diagnosis, Heart Failure epidemiology, Heart Failure prevention & control
- Abstract
Aims: In bradycardia patients treated with dual-chamber pacing, we aimed to evaluate whether pacing with atrioventricular (AV) delay management [AV hysteresis (AVH)], compared with standard pacing with fixed AV delays, reduces unnecessary ventricular pacing percentage (VPP) and is associated with better clinical outcomes. Main study endpoints were the incidence of heart failure hospitalizations (HFH), persistent atrial fibrillation (AF), and cardiac death., Methods and Results: Data from two identical prospective observational studies, BRADYCARE I in the USA and BRADYCARE II in Europe, Africa, and Asia, were pooled. Overall, 2592 patients (75 ± 10 years, 45.1% female, 50% with AVH) had complete clinical and device data at 1-year follow-up and were analysed. Primary pacing indication was sinus node disease (SND) in 1177 (45.4%), AV block (AVB) in 974 (37.6%), and other indications in 441 (17.0%) patients. Pacing with AVH, compared with standard pacing, was associated with a lower 1-year incidence of HFH [1.3% vs. 3.1%, relative risk reduction (RRR) 57.5%, P = 0.002] and of persistent AF (5.3% vs. 7.7%, RRR = 31.1%, P = 0.028). Cardiac mortality was not different between groups (1.0% vs. 1.4%, RRR = 27.8%, P = 0.366). Pacing with AVH, compared with standard pacing, was associated with a lower (P < 0.001) median VPP in all patients (7% vs. 75%), in SND (3% vs. 44%), in AVB (25% vs. 98%), and in patients with other pacing indications (3% vs. 47%)., Conclusion: Cardiac pacing with AV delay management via AVH is associated with reduced 1-year incidence of HFH and persistent AF, most likely due to a reduction in VPP compared to standard pacing., Competing Interests: Conflict of interest: M.A. participated in clinical trials sponsored by Abbott and Biotronik; he received speaker honoraria from Biotronik. A.A. participated in clinical trials sponsored by Boston Scientific, Medtronic, EPD Philips, and XSpline; he received consultant or speaker fees from Abbott, Boston Scientific, Cairdac, Corvia, EP Solution, Microport CRM, Philips, Radcliffe Publishers, and XSpline, and he has intellectual properties with Boston Scientific, Biosense Webster, and Microport CRM. A.A. is the review editor of EP Europace and was not involved in the peer review process or publication decision. G.B. received speaker fees from Boston Scientific, Abbott, Daiichi, and Boehringer Ingelheim. A.P., W.L., and A.G. are Abbott employees. All remaining authors have declared no conflicts of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2023
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