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798 results on '"Gwak, Geum Youn"'

202. Repeated Hepatic Resection versus Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma after Hepatic Resection: A Propensity Score Matching Study

Author

Song, Kyoung Doo, primary, Lim, Hyo Keun, additional, Rhim, Hyunchul, additional, Lee, Min Woo, additional, Kim, Young-sun, additional, Lee, Won Jae, additional, Paik, Yong Han, additional, Gwak, Geum-Youn, additional, Kim, Jong Man, additional, Kwon, Choon Hyuck David, additional, and Joh, Jae-Won, additional

Published
2015
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203. Sorafenib therapy for hepatocellular carcinoma with extrahepatic spread: Treatment outcome and prognostic factors

Author

Sohn, Won, primary, Paik, Yong-Han, additional, Cho, Ju-Yeon, additional, Lim, Ho Yeong, additional, Ahn, Jem Ma, additional, Sinn, Dong Hyun, additional, Gwak, Geum-Youn, additional, Choi, Moon Seok, additional, Lee, Joon Hyeok, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, and Yoo, Byung Chul, additional

Published
2015
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207. Hepatocellular Carcinoma Risk of Compensated Cirrhosis Patients with Elevated HBV DNA Levels according to Serum Aminotransferase Levels

Author

Lee, Junggyu, primary, Sinn, Dong Hyun, additional, Kim, Jung Hee, additional, Gwak, Geum-Youn, additional, Kim, Hye Seung, additional, Jung, Sin-Ho, additional, Paik, Yong-Han, additional, Choi, Moon Seok, additional, Lee, Joon Hyeok, additional, Koh, Kwang Cheol, additional, Yoo, Byung Chul, additional, and Paik, Seung Woon, additional

Published
2015
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211. Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure

Author

Ha, Jung Min, primary, Sohn, Won, additional, Cho, Ju Yeon, additional, Pyo, Jeung Hui, additional, Choi, Kyu, additional, Sinn, Dong Hyun, additional, Gwak, Geum-Youn, additional, Choi, Moon Seok, additional, Lee, Joon Hyeok, additional, Koh, Kwang Chul, additional, Paik, Seung Woon, additional, Yoo, Byung Chul, additional, and Paik, Yong-Han, additional

Published
2015
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222. Mo1032 The Risk of Spontaneous Bacterial Peritonitis Associated With Proton Pump Inhibitor Use in Cirrhotic Patients With Ascites: Long-Term Outcome in the Propensity Score-Matched Cohort

Author

Lim, Kyung Suk, primary, Min, Yang Won, additional, Min, Byung Hoon, additional, Gwak, Geum-Youn, additional, Paik, Yong Han, additional, Lee, Jun Haeng, additional, Choi, Moon Seok, additional, Lee, Joon Hyoek, additional, Kim, Jae J, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, Yoo, Byung Chul, additional, and Rhee, Poong-Lyul, additional

Published
2014
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223. Clinical Features, Image Findings, and Prognosis of Inflammatory Pseudotumor of the Liver: A Multicenter Experience of 45 Cases

Author

Park, Jun Young, primary, Choi, Moon Seok, additional, Lim, Young-Suk, additional, Park, Jang Won, additional, Kim, Seung Up, additional, Min, Yang Won, additional, Gwak, Geum-Youn, additional, Paik, Yong-Han, additional, Lee, Joon Hyoek, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, and Yoo, Byung Chul, additional

Published
2014
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228. Relationship of Liver Stiffness and Controlled Attenuation Parameter Measured by Transient Elastography with Diabetes Mellitus in Patients with Chronic Liver Disease

Author

Ahn, Jem Ma, primary, Paik, Yong-Han, additional, Kim, So Hyun, additional, Lee, Jun Hee, additional, Cho, Ju Yeon, additional, Sohn, Won, additional, Gwak, Geum-Youn, additional, Choi, Moon Seok, additional, Lee, Joon Hyeok, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, and Yoo, Byung Chul, additional

Published
2014
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229. Predisposing factors for recurrence of HBV-related small hepatocellular carcinoma after percutaneous radiofrequency ablation

Author

Sohn, Won, primary, Paik, Yong-Han, additional, Lee, Min Woo, additional, Rhim, Hyunchul, additional, Lim, Hyo Keun, additional, Cho, Ju Yeon, additional, Gwak, Geum-Youn, additional, Choi, Moon Seok, additional, Lee, Joon Hyeok, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, and Yoo, Byung Chul, additional

Published
2013
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232. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

Author

Pradere, Jean-Philippe, primary, Kluwe, Johannes, additional, De Minicis, Samuele, additional, Jiao, Jing-Jing, additional, Gwak, Geum-Youn, additional, Dapito, Dianne H., additional, Jang, Myoung-Kuk, additional, Guenther, Nina D., additional, Mederacke, Ingmar, additional, Friedman, Richard, additional, Dragomir, Ana-Cristina, additional, Aloman, Costica, additional, and Schwabe, Robert F., additional

Published
2013
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235. Clinical parameters predictive of outcomes in sorafenib‐treated patients with advanced hepatocellular carcinoma

Author

Cho, Ju‐Yeon, primary, Paik, Yong‐Han, additional, Lim, Ho Yeong, additional, Kim, Young Gon, additional, Lim, Hyo Keun, additional, Min, Yang Won, additional, Gwak, Geum‐Youn, additional, Choi, Moon Seok, additional, Lee, Joon Hyeok, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, and Yoo, Byung Chul, additional

Published
2013
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236. The Efficacy of High-dose 3-Dimensional Conformal Radiation Therapy in Patients With Small Hepatocellular Carcinoma Not Eligible for Other Local Modalities

Author

Lim, Do Hoon, primary, Lee, Hyebin, additional, Park, Hee Chul, additional, Lee, Jung Ae, additional, Kim, Sang Won, additional, Yoo, Byung Chul, additional, Koh, Kwang Cheol, additional, Lee, Joon Hyeok, additional, Choi, Moon Seok, additional, Gwak, Geum Youn, additional, and Paik, Seung Woon, additional

Published
2013
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237. Risk factors and a predictive model for acute hepatic failure after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma

Author

Min, Yang Won, primary, Kim, Jeong, additional, Kim, Seonwoo, additional, Sung, Young Kyung, additional, Lee, Jin Hee, additional, Gwak, Geum‐Youn, additional, Paik, Yong Han, additional, Choi, Moon Seok, additional, Koh, Kwang Cheol, additional, Paik, Seung Woon, additional, Yoo, Byung Chul, additional, and Lee, Joon Hyeok, additional

Published
2013
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238. Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: Analysis of prognostic factors

Author

Kim, Young-sun, primary, Lim, Hyo Keun, additional, Rhim, Hyunchul, additional, Lee, Min Woo, additional, Choi, Dongil, additional, Lee, Won Jae, additional, Paik, Seung Woon, additional, Koh, Kwang Cheol, additional, Lee, Joon Hyeok, additional, Choi, Moon Seok, additional, Gwak, Geum-Youn, additional, and Yoo, Byung Chul, additional

Published
2013
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239. Primary Prophylaxis for Variceal Bleeding and the Improved Survival of Patients with Newly Diagnosed Hepatocellular Carcinoma.

Author

Kim, Jung, Sinn, Dong, Kim, Kyunga, Kang, Wonseok, Gwak, Geum-Youn, Paik, Yong-Han, Choi, Moon, Lee, Joon, Koh, Kwang, Paik, Seung, Kim, Jung Hee, Sinn, Dong Hyun, Choi, Moon Seok, Lee, Joon Hyeok, Koh, Kwang Cheol, and Paik, Seung Woon

Subjects
LIVER cancer, HEMORRHAGE, DISEASE complications, PREVENTIVE medicine, FOLLOW-up studies (Medicine), RETROSPECTIVE studies
Abstract

Background and Aims: We evaluated the impact of primary variceal bleeding prophylaxis on long-term outcomes of patients newly diagnosed with hepatocellular carcinoma (HCC).Methods: A retrospective cohort of 898 patients newly diagnosed with HCC without a history of variceal bleeding [age 57.4 ± 10.4, males 718 (80.0 %)] were analyzed for new onset variceal bleeding during follow-up.Results: Variceal bleeding occurred in 72 patients (8.0 %) during follow-up. The presence of portal vein thrombosis [hazard ratio (HR) 3.90; 95 % confidence interval (CI) 2.09-7.30; p < 0.001] and the presence of the red color sign or ≥grade 2 varices at index endoscopy (HR 7.64; 95 % CI 4.56-12.80; p < 0.001) were independent risk factors for variceal bleeding. The occurrence of variceal bleeding was an independent risk factor for mortality (HR 1.39; 95 % CI 1.06-1.82; p = 0.015). The cumulative incidence rate of variceal bleeding at 1 year was 2.1, 15.3, and 34.2 % for those non-indicated for primary prophylaxis (n = 760), indicated for primary prophylaxis and received prophylaxis (n = 98), and indicated for primary prophylaxis but did not received prophylaxis (n = 40) (p < 0.001). Primary prophylaxis for variceal bleeding for indicated patients was associated with a reduced risk of mortality in all patients (HR 0.54; 95 % CI 0.33-0.88; p = 0.014) and in propensity-matched patients (HR, 0.54; 95 % CI 0.31-0.95; p = 0.033).Conclusion: Variceal bleeding was independent risk factor for survival of newly diagnosed HCC patients. Screening and providing primary prophylaxis for indicated patients should be considered for patients with HCC. [ABSTRACT FROM AUTHOR]

Published
2016
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240. Magnetic resonance imaging with gadoxetic acid for local tumour progression after radiofrequency ablation in patients with hepatocellular carcinoma.

Author

Kang, Tae, Rhim, Hyunchul, Lee, Jisun, Song, Kyoung, Lee, Min, Kim, Young-sun, Lim, Hyo, Jang, Kyung, Kim, Seong, Gwak, Geum-Youn, Jung, Sin-Ho, Kang, Tae Wook, Song, Kyoung Doo, Lee, Min Woo, Lim, Hyo Keun, Jang, Kyung Mi, and Kim, Seong Hyun

Subjects
LIVER cancer, CATHETER ablation, CANCER invasiveness, SURVIVAL analysis (Biometry), MAGNETIC resonance imaging
Abstract

Objectives: To develop and validate a prediction model using magnetic resonance imaging (MRI) for local tumour progression (LTP) after radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) patients.Methods: Two hundred and eleven patients who had received RFA as first-line treatment for HCC were retrospectively analyzed. They had undergone gadoxetic acid-enhanced MRI before treatment, and parameters including tumour size; margins; signal intensities on T1-, T2-, and diffusion-weighted images, and hepatobiliary phase images (HBPI); intratumoral fat or tumoral capsules; and peritumoural hypointensity in the HBPI were used to develop a prediction model for LTP after treatment. This model to discriminate low-risk from high-risk LTP groups was constructed based on Cox regression analysis.Results: Our analyses produced the following model: 'risk score = 0.617 × tumour size + 0.965 × tumour margin + 0.867 × peritumoural hypointensity on HBPI'. This was able to predict which patients were at high risk for LTP after RFA (p < 0.001). Patients in the low-risk group had a significantly better 5-year LTP-free survival rate compared to the high-risk group (89.6 % vs. 65.1 %; hazard ratio, 3.60; p < 0.001).Conclusion: A predictive model based on MRI before RFA could robustly identify HCC patients at high risk for LTP after treatment.Key Points: • Tumour size, margin, and peritumoural hypointensity on HBPI were risk factors for LTP. • The risk score model can predict which patients are at high risk for LTP. • This prediction model could be helpful for risk stratification of HCC patients. [ABSTRACT FROM AUTHOR]

Published
2016
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241. Factors determining long-term outcomes of hepatocellular carcinoma within the Milan criteria: liver transplantation versus locoregional therapy: A retrospective cohort study.

Author

Jung Hee Kim, Dong Hyun Sinn, Geum-Youn Gwak, Gyu-Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Ki Yeon Kim, Kyunga Kim, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Kim, Jung Hee, Sinn, Dong Hyun, Gwak, Geum-Youn, Choi, Gyu-Seong, Kim, Jong Man, and Kwon, Choon Hyuck David

Published
2016
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242. The associations between apolipoprotein B, A1, and the B/A1 ratio and nonalcoholic fatty liver disease in both normal-weight and overweight Korean population.

Author

Yang, Moon Hee, Sung, Jidong, and Gwak, Geum-Youn

Subjects
NON-alcoholic fatty liver disease, CROSS-sectional method, PROBABILITY theory, DESCRIPTIVE statistics, MULTIVARIATE analysis, ODDS ratio, METABOLIC syndrome, APOLIPOPROTEINS, CONFIDENCE intervals, OBESITY, DISEASE complications
Abstract

Background Nonalcoholic fatty liver disease (NAFLD) is associated with a higher risk of cardiovascular disease, but the relationship has not been established in nonobese populations. Higher apolipoprotein B (apo B) levels and the apo B/A1 ratio and lower apo A1 levels are associated with an elevated risk of cardiovascular disease. We investigated the associations between apo B, apo A1, and the apo B/A1 ratio and the presence of metabolic syndrome and NAFLD in both normal-weight and overweight Koreans. Methods This cross-sectional study consisted of 8327 consecutive both normal-weight and overweight Koreans with NAFLD diagnosed by ultrasonography at the Samsung Medical Center in Korea from January 2008 to December 2010. Results The prevalence of NAFLD was 27.1% among the 8327 participants. Higher serum triglyceride levels and the apo B/A1 ratio and lower high-density lipoprotein cholesterol and apo A1 levels were significantly associated with higher prevalence of metabolic syndrome in both normal-weight group and overweight group. The multivariate-adjusted odds ratios (ORs) for NAFLD in normal-weight group after comparing the fourth vs the first quartiles of the triglyceride, HDL cholesterol, low-density lipoprotein (LDL) cholesterol, apo B, apo A1, and the apo B/A1 ratio data were 2.89 (95% confidence interval [CI], 2.19–3.83; P trend < .001), 0.60 (95% CI, 0.46–0.78; P trend < .001), 1.67 (95% CI, 1.33–2.11; P trend < .001), 1.88 (95% CI, 1.48–2.39; P trend < .001), 0.73 (95% CI, 0.58–0.93; P trend < .001), and 1.86 (95% CI, 1.45–2.38; P trend < .001), respectively. The corresponding adjusted ORs in the overweight group were 3.43 (95% CI, 2.60–4.54; P trend < .001), 0.89 (95% CI, 0.68–1.16; P trend = .221), 1.41 (95% CI, 1.11–1.78; P trend = .001), 1.58 (95% CI, 1.21–2.06; P trend < .001), 0.99 (95% CI, 0.77–1.27; P trend = .958), and 1.53 (1.16–2.01; P trend = .002), respectively. Conclusions Higher serum triglyceride, LDL cholesterol, apo B1 levels, and the apo B/A1 ratio were significantly associated with NAFLD independent of metabolic syndrome in both normal-weight and overweight Koreans. Lower serum HDL cholesterol and apo A1 levels were related to NAFLD in normal-weight participants. Our results suggest that the presence of NAFLD may be associated with increased risk for coronary artery disease in both normal-weight and overweight Koreans. [ABSTRACT FROM AUTHOR]

Published
2016
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245. Stopping Preemptive Antiviral Therapy for Hepatitis B Virus Can Be Considered for Patients with Favorable Predictors.

Author

Kim, Hyo, Sinn, Dong, Kim, Nam, Kim, Jung, Kim, Eun, Gwak, Geum-Youn, Paik, Yong-Han, Choi, Moon, Lee, Joon, Koh, Kwang, Paik, Seung, Yoo, Byung, Kim, Hyo Jin, Sinn, Dong Hyun, Kim, Nam Jun, Kim, Jung Hee, Choi, Moon Seok, Lee, Joon Hyeok, Koh, Kwang Cheol, and Paik, Seung Woon

Subjects
ANTIVIRAL agents, HEPATITIS B, ODDS ratio, CANCER chemotherapy, MANN Whitney U Test, UNIVARIATE analysis, RECEIVER operating characteristic curves
Abstract

Background: Preemptive antiviral therapy is recommended for chronic hepatitis B virus (HBV)-infected patients receiving cytotoxic chemotherapy. However, little data are available for the stopping therapy.Aims: We evaluated clinical outcome and predictors of off-treatment virological response of patients who discontinued therapy.Methods: Ninety-five adult patients who discontinued therapy were enrolled. They were analyzed for sustained off-treatment virological response, defined as HBV DNA levels below 2000 IU/ml for at least 12 months after the end of therapy.Results: Sustained off-treatment virological response was seen in 52 patients (54.7%). The baseline HBV DNA level was an independent factor associated with sustained off-treatment virological response, and the rate was 72.1 and 23.5% for those with HBV DNA < 2000 IU/ml and ≥ 2000 IU/ml, respectively (P < 0.001). The duration of consolidation treatment showed marginal association with sustained off-treatment virological response [odd ratio (95% confidence interval) 1.20 (0.98-1.47), P = 0.069] for those with baseline HBV DNA < 2000 IU/ml, but not for those with ≥ 2000 IU/ml. The sustained off-treatment virological response rate was 54.5, 71.4, 73.9, and 100% for consolidation treatment duration of <3, 3-6, 6-12, and ≥ 12 months, respectively, among those with baseline HBV DNA < 2000 IU/ml.Conclusions: The baseline HBV DNA level was indicator for sustained off-treatment virological response after stopping preemptive antiviral therapy. Consolidation treatment duration showed association with sustained off-treatment virological response only for those with low baseline HBV DNA levels. [ABSTRACT FROM AUTHOR]

Published
2015
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