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206. Behandlungskosten bei RA-Patienten unter DMARD-Dosisreduktion - eine ökonomische Analyse der prospektiven, randomisiert-kontrollierten RETRO-Studie

Author

Hagen, M, Haschka, J, Reiser, M, Figueiredo, CP, Cobra, JF, Englbrecht, M, Hueber, A, Manger, B, Kleyer, A, Finzel, S, Tony, HP, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüßlein, HG, Alten, RHE, Henes, J, Krüger, K, Schett, G, Rech, J, Hagen, M, Haschka, J, Reiser, M, Figueiredo, CP, Cobra, JF, Englbrecht, M, Hueber, A, Manger, B, Kleyer, A, Finzel, S, Tony, HP, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüßlein, HG, Alten, RHE, Henes, J, Krüger, K, Schett, G, and Rech, J

Published
2016

207. DISEASE PROGRESSION IN 282 PATIENTS WITH UNDIFFERENTIATED SSC - DATA FROM THE GERMAN NETWORK FOR SYSTEMIC SCLERODERMA

Author

Moinzadeh, P., Blank, N., Siegert, E., Henes, J., Susok, L., Distler, J. H. W., Juche, A., Worm, M., Gil, H. C., Schmeiser, T., Zeidler, G., Gaebelein-Wissing, N., Krieg, T., Sunderkoetter, C., Kreuter, A., Sardy, M., Riemekasten, G., Mueller-Ladner, U., Frerix, M., Kuhr, K., Hunzelmann, N., Moinzadeh, P., Blank, N., Siegert, E., Henes, J., Susok, L., Distler, J. H. W., Juche, A., Worm, M., Gil, H. C., Schmeiser, T., Zeidler, G., Gaebelein-Wissing, N., Krieg, T., Sunderkoetter, C., Kreuter, A., Sardy, M., Riemekasten, G., Mueller-Ladner, U., Frerix, M., Kuhr, K., and Hunzelmann, N.

Published
2016

209. The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase‐1 antibodies

Author

Hunzelmann, Nicolas, Riemekasten, G., Becker, M.O., Moinzadeh, Pia, Kreuter, Alexander, Melchers, I., Müller‐Ladner, Ulf, Meier, Friedegund, Worm, Margitta, Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sardy, Miklos, Burkhardt, H., Koehm, M., Kuhr, K., Krieg, Thomas M., Sunderkötter, C., Hunzelmann, Nicolas, Riemekasten, G., Becker, M.O., Moinzadeh, Pia, Kreuter, Alexander, Melchers, I., Müller‐Ladner, Ulf, Meier, Friedegund, Worm, Margitta, Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sardy, Miklos, Burkhardt, H., Koehm, M., Kuhr, K., Krieg, Thomas M., and Sunderkötter, C.

Published
2016

210. The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase-1 antibodies

Author

Hunzelmann, N., Riemekasten, G., Becker, M. O., Moinzadeh, P., Kreuter, A., Melchers, I., Mueller-Ladner, U., Meier, F., Worm, M., Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Guenther, C., Sardy, M., Burkhardt, H., Koehm, M., Kuhr, K., Krieg, T., Sunderkoetter, C., Hunzelmann, N., Riemekasten, G., Becker, M. O., Moinzadeh, P., Kreuter, A., Melchers, I., Mueller-Ladner, U., Meier, F., Worm, M., Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Guenther, C., Sardy, M., Burkhardt, H., Koehm, M., Kuhr, K., Krieg, T., and Sunderkoetter, C.

Published
2016

215. AB0545 Interferon Alpha2a versus Cyclosporin A for The Treatment of Severe Ocular Behcet's Disease – A Prospective, Randomised, Single Blind, National Multicenter Trial (INCYTOB)

Author

Kötter, I., primary, Vonthein, R., additional, Schoenfisch, B., additional, Xenitidis, T., additional, Doycheva, D., additional, Henes, J., additional, Stübiger, N., additional, Feist, E., additional, Heiligenhaus, A., additional, Rath, T., additional, Max, R., additional, Mackensen, F., additional, Altenburg, A., additional, Krause, L., additional, Zouboulis, C., additional, Blaschke, S., additional, Horn, M., additional, Neß, T., additional, Goldacker, S., additional, and Deuter, C., additional

Published
2016
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222. ORAL AB AGORA1362Cardiac Involvement in Patients With Different Rheumatic Disorders1366Gender differences in the development of cardiac complications: a multicentric prospective study in a large cohort of thalassemia major patients1646Comparison of T1-mapping, T2-weighted and contrast-enhanced cine imaging at 3.0T CMR for diagnostic oedema assessment in ST-segment elevation myocardial infarction1375Evaluation of Tissue Changes in Remote Noninfarcted Myocardium after Acute Myocardial Infarction using T1-mapping1377Right ventricular long axis strain – The prognostic value of a novel parameter in non-ischemic dilated cardiomyopathy using standard cardiac magnetic resonance imaging1389The role of the right ventricular insertion point in heart failure patients with preserved ejection fraction: Insights from a cardiovascular magnetic resonance study1398Myocardial fibrosis associates with B-type natriuretic peptide levels and outcomes more than wall stress1478Prognostic Value of Pulmonary Blood Volume by Contrast-Enhanced Magnetic Resonance Imaging in Heart Failure Outpatients – The PROVE-HF Study1370Magnetic Resonance Adenosine Perfusion Imaging as Gatekeeper of Invasive Coronary1509Influence of non-invasive hemodynamic CMR parameters on maximal exercise capacity in surgically untreated patients with Ebstein's anomaly1356Proximal aortic stiffening in Turner patients is more pronounced in the presence of a bicuspid valve. A segmental functional MRI study1503Flow pattern and vascular distensibility of the pulmonary arteries in patients after repair of tetralogy of Fallot. Insights from 4D flow CMR1516Myocardial deformation characteristics of the systemic right ventricle after atrial switch operation for transposition of the great arteries1633Three-dimensional vortex formation in patients with a Fontan circulation: evaluation with 4D flow CMR1483Mitral valve prolapse: arrhythmogenic substrates by cardiac magnetic imaging1596Increased local wall shear stress after coarctation repair is associated with descending aorta pulse wave velocity: evaluation with CMR and 4D flow1636Three-dimensional wall shear stress assessed by 4Dflow CMR in bicuspid aortic valve disease1464Cardiac Amyloidosis and Aortic Stenosis – The Convergence of Two Aging Processes1630Blood T1 variability explained in healthy volunteers: an analysis on MOLLI, ShMOLLI and SASHA1408Myocardial deformation on CMR predicts adverse outcomes in carcinoid heart disease - a new marker of risk1492Myocardial Perfusion Reserve and Global Longitudinal Strain in Early Rheumatoid Arthritis1500Exercise CMR to differentiate athlete's heart from patients with early dilated cardiomyopathy1559Real-Time, x-mri guidance to optimise left ventricular lead placement for delivery of cardiac resynchronisation therapy1560The role of Cardiac magnetic resonance imaging in patients undergoing ablation for ventricular tachycardia- Defining the substrate and visualizing the outcome1590Impact of cardiovascular magnetic resonance on clinical management and decision-making of out of hospital cardiac arrest survivors with inconclusive coronary angiogram1561Detection of coronary stenosis at rest using Oxygenation-Sensitive Magnetic Resonance Imaging

Author

Greulich, S., primary, Meloni, A., primary, Nazir, Sheraz A., primary, Stefan Biesbroek, P., primary, Arenja, Nisha, primary, Kammerlander, Andreas A., primary, Sayeed, Aatif, primary, Ricci, F., primary, Bernhardt, Peter, primary, Meierhofer, Christian, primary, Devos, Daniel G.H., primary, Ruecker, Beate, primary, Burkhardt, B.E.U., primary, Kamphuis, Vivian P., primary, De Lazzari, Manuel, primary, Nederend, I., primary, Dux-Santoy, Lydia, primary, Cavalcante, João L., primary, Rosmini, Stefania, primary, Liu, B., primary, Fent, G.J., primary, Claessen, G., primary, Behar, Jonathan, primary, Oebel, S., primary, Baritussio, A., primary, Ranjit Arnold, J., primary, Kitterer, D., additional, Latus, J., additional, Henes, J., additional, Kurmann, R., additional, Gloekler, S., additional, Wahl, A., additional, Buss, S., additional, Katus, H., additional, Bobbo, M., additional, Lombardi, M., additional, Braun, N., additional, Alscher, M.D., additional, Sechtem, U., additional, Mahrholdt, H., additional, Neri, M.G., additional, Preziosi, P., additional, Grassedonio, E., additional, Schicchi, N., additional, Keilberg, P., additional, Pulini, S., additional, Facchini, E., additional, Positano, V., additional, Pepe, A., additional, Shetye, Abhishek, additional, Khan, Jamal N., additional, Singh, Anvesha, additional, Kanagala, Prathap, additional, Swarbrick, Daniel, additional, Gulsin, Gaurav, additional, Graham-Brown, Matthew, additional, Squire, Iain, additional, Gershlick, Anthony, additional, McCann, Gerry P., additional, Amier, Raquel P., additional, Teunissen, Paul F.A., additional, Robbers, Lourens F.H.J., additional, Beek, Aernout M., additional, van Rossum, Albert C., additional, Hofman, Mark B.M., additional, van Royen, Niels, additional, Nijveldt, Robin, additional, Riffel, Johannes H, additional, Djiokou, Charly Noel, additional, Andre, Florian, additional, Fritz, Thomas, additional, Halder, Manuel, additional, Thomas, Zelniker, additional, Korosoglou, Grigorios, additional, Katus, Hugo A, additional, Buss, Sebastian J, additional, Schwaiger, Marianne L., additional, Duca, Franz, additional, Aschauer, Stefan, additional, Marzluf, Beatrice A., additional, Zotter-Tufaro, Caroline, additional, Dalos, Daniel, additional, Pfaffenberger, Stefan, additional, Bonderman, Diana, additional, Mascherbauer, Julia, additional, Fridman, Yaron, additional, Hackman, Brianne, additional, Kadakkal, Ajay, additional, Maanja, Maren, additional, Daya, Hussein Abu, additional, Wong, Timothy C., additional, Schelbert, Erik B., additional, Barison, A., additional, Todiere, G., additional, Gaeta, R., additional, Galllina, S., additional, Emdin, M., additional, De Caterina, R., additional, Aquaro, G.D., additional, Buckert, Dominik, additional, Dyckmanns, Nils, additional, Rottbauer, Wolfgang, additional, Kühn, Andreas, additional, Shehu, Nerejda, additional, Müller, Jan, additional, Stern, Heiko, additional, Ewert, Peter, additional, Fratz, Sohrab, additional, Vogt, Manfred, additional, De Groote, Katya, additional, Babin, Danilo, additional, Demulier, Laurent, additional, Taeymans, Yves, additional, Westenberg, Jos J., additional, Van Bortel, Luc, additional, Segers, Patrick, additional, Achten, Eric, additional, De Schepper, Jean, additional, Rietzschel, Ernst, additional, Geiger, Julia, additional, Makki, Malek, additional, Burkhardt, Barbara, additional, Kellenberger, Christian J., additional, Buechel, Emanuela R. Valsangiacomo, additional, Kellenberger, C.J., additional, Geiger, J., additional, Ruecker, B., additional, Buechel, E.R. Valsangiacomo, additional, Elbaz, Mohammed S.M., additional, Kroft, Lucia J.M., additional, van der Geest, Rob J., additional, de Roos, Albert, additional, Blom, Nico A., additional, Westenberg, Jos J.M., additional, Roest, Arno A.W., additional, Cipriani, Alberto, additional, Susana, Angela, additional, Rizzo, Stefania, additional, Giorgi, Benedetta, additional, Carmelo, Lacognata, additional, Bertaglia, Emanuele, additional, Bauce, Barbara, additional, Corrado, Domenico, additional, Thiene, Gaetano, additional, Marra, Martina Perazzolo, additional, Basso, Cristina, additional, Iliceto, Sabino, additional, Roest, A.A.W., additional, van den Boogaard, P.J., additional, ten Harkel, A.D.J., additional, de Geus, J.C.N., additional, Kroft, L.J.M., additional, de Roos, A., additional, Westenberg, J.J.M., additional, Kale, Raquel, additional, Teixido-Tura, Gisela, additional, Maldonado, Giuliana, additional, Huguet, Marina, additional, Garcia-Dorado, David, additional, Evangelista, Artur, additional, Rodriguez-Palomares, Jose, additional, Rijal, Shasank, additional, Schindler, John T., additional, Gleason, Thomas G., additional, Lee, Joon S., additional, Bulluck, Heerajnarain, additional, Treibel, Thomas A, additional, Bhuva, Anish, additional, Abdel-Gadir, Amna, additional, Culotta, Veronica, additional, Merghani, Ahmed, additional, Maestrini, Viviana, additional, Herrey, Anna S, additional, Kellman, Peter, additional, Manisty, Charlotte, additional, Moon, James C, additional, Hayer, M.K., additional, Baig, S., additional, Shah, T., additional, Rooney, S.J., additional, Edwards, N.C., additional, Steeds, R.P., additional, Garg, P., additional, Swoboda, P., additional, Dobson, L.E., additional, Musa, T.A., additional, Foley, J.F., additional, Haaf, P., additional, Greenwood, J.P., additional, Plein, S., additional, Schnell, F., additional, Bogaert, J., additional, Dymarkowski, S., additional, Pattyn, N., additional, Claus, P., additional, Van Cleemput, J., additional, Gerche, A. La, additional, Heidbuchel, H., additional, Toth, Daniel, additional, Reiml, Sabrina, additional, Panayiotou, Maria, additional, Claridge, Simon, additional, Jackson, Tom, additional, Sohal, Manav, additional, Webb, Jessica, additional, O'Neill, Mark, additional, Brost, Alexander, additional, Mountney, Peter, additional, Razavi, Reza, additional, Rhode, Kawal, additional, Rinaldi, Christopher Aldo, additional, Arya, A., additional, Hilbert, S., additional, Bollmann, A., additional, Hindricks, G., additional, Jahnke, C., additional, Paetsch, I., additional, Dinov, B., additional, Perazzolo Marra, M., additional, Ghosh Dastidar, A., additional, Rodrigues, J., additional, Zorzi, A., additional, Susana, A., additional, Scatteia, A., additional, De Garate, E., additional, Mattesi, G., additional, Strange, J., additional, Corrado, D., additional, Bucciarelli-Ducci, C., additional, Jerosch-Herold, Michael, additional, Karamitsos, Theodoros D., additional, Francis, Jane M., additional, Bhamra-Ariza, Paul, additional, Sarwar, Rizwan, additional, Choudhury, Robin, additional, Selvanayagam, Joseph B., additional, and Neubauer, Stefan, additional

Published
2016
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223. Leflunomide as a maintenance treatment for neuro-behcet's disease

Author

Xenitidis, T, Kötter, I, and Henes, J

Subjects
neuro-behcet's disease, ddc: 610, treatment, 610 Medical sciences, Medicine, Leflunomide, maintenance
Abstract

Background: Neuro-Behçet`s disease (NBD) is categorised into parenchymal or nonparenchymal involvement. For parenchymal CNS involvement corticosteroids, IFNα, azathioprine, cyclophosphamide, methotrexate and TNFα-antagonists are recommended. There is a broad agreement to start [for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2014
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224. Wirksamkeit und Einsparpotential von Glucocorticoiden unter Tocilizumab-Therapie bei Rheumatoider Arthritis (RA) mit und ohne csDMARDS

Author

Specker, C, Kaufmann, J, Vollmer, MA, Kellner, H, Höhle, M, Kühne, C, Volberg, C, Henes, J, Zinke, S, Moosig, F, Bohl-Bühler, M, Sieburg, M, Aringer, M, Hofmann, MW, Hellmann, P, and Fliedner, G

Subjects
ddc: 610, Rheumatoide Arthritis, Tocilizumab, 610 Medical sciences, Medicine
Abstract

Einleitung: Unterscheiden sich die Ansprechraten der RA oder die Möglichkeit, Glucocorticoide (GC) einzusparen unter einer Therapie mit Tocilizumab (TCZ) in Abhängigkeit von einer Begleittherapie mit konventionellen, synthetischen DMARDs (csDMARDs)? Methoden: In der ICHIBAN-Studie [for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2014
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226. Analyse einer Spezialsprechstunde für Autoinflammation bei Erwachsenen an der Uniklinik Tübingen

Author

Igney-Oertel, A and Henes, J

Subjects
familiäres Mittelmeerfieber, ddc: 610, Autoinflammation, Fiebersyndrome, Still, TRAPS, Muckle-Wells, 610 Medical sciences, Medicine
Abstract

Einleitung: Autoinflammatorische Erkrankungen sind vermehrt in den Fokus der Rheumatologie gerückt. Weiterhin stellen Diagnostik und Therapie eine Herausforderung dar. Wir haben seit 8 Jahren eine spezialisierte Spechstunde für autoinflammatorische Erkrankungen in Tübingen etabliert. [for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2014
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227. Schwere Polychondritis mit Befall der Trachea erfolgreich behandelt mit Tocilizumab – Therapiemonitoring mittels MRT

Author

Henes, J, Xenitidis, T, Kanz, L, Wagner, M, and Horger, M

Subjects
ddc: 610, 610 Medical sciences, Medicine, Polychondritis, Tocilizumab, MRT
Abstract

Einleitung: Die rezidivierende Polychondritis (RP) ist eine sehr seltene Autoimmunerkrankung, gekennzeichnet durch wiederkehrende entzündliche Knorpelveränderungen, welche aufgrund von konsekutiven Knorpeldeformitäten lebensbedrohlich verlaufen kann. Aufgrund der Seltenheit der Erkrankung[for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2014
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228. Veränderungen des Thymus vor und nach autologer Stammzelltransplantation bei Patienten mit Systemsklerose

Author

Henes, J, Wagner, M, Xenitidis, T, Kanz, L, and Horger, M

Subjects
ddc: 610, autologe Stammzelltransplantation, 610 Medical sciences, Medicine, Systemsklerose, Thymus
Abstract

Einleitung: Die Pathogenese der Systemsklerose (SSc) ist weiterhin unverstanden. Aktuelle Studien fanden gehäuft eine inkomplette Thymus Rückbildung bei Ssc Patienten und äußerten den Verdacht, dass Thymus Auffälligkeiten das Risiko von Autoimmunerkrankungen möglicherweise[for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2014
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229. Differenzialdiagnose der Hypereosinophilie

Author

Henes, J. C., Wirths, S., and Hellmich, B.

Abstract

Als Eosinophilie bezeichnet man eine Erhöhung der absoluten Eosinophilenzahl und unterscheidet hierüber auch bezüglich der Schwere. Die häufigsten Ursachen sind allergische (auch Medikamentennebenwirkungen) und infektiöse Auslöser, aber auch maligne und autoimmune Erkrankungen können mit einer Eosinophilie einhergehen. Ausgeprägte Eosinophilien mit Eosinophilenzahlen >5000/µl finden sich meist bei myeloproliferativen Erkrankungen, der eosinophilen Granulomatose mit Polyangiitis (EGPA) und bei Gewebsmigration von Gewebeparasiten. Als hypereosinophiles Syndrom bezeichnet man eine über 6 Monate bestehende Eosinophilie mit >1500 Eosinophilen/µl bei Ausschluss einer Parasitose, Allergie oder anderer Ursache und Zeichen einer Gewebeeosinophilie mit Endorganschädigung. Zur Abklärung sollten bei persistierender Eosinophilie neben einer genauen Anamnese und körperlichen Untersuchung auch früh ein Organscreening, eine Wurmdiagnostik sowie eine hämatologische Labordiagnostik inklusive Knochenmarkuntersuchung erwogen werden.

Published
2019
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230. Secondary autoimmune diseases occurring after HSCT for an autoimmune disease: a retrospective study of the EBMT Autoimmune Disease Working Party

Author

Daikeler, T., Labopin, M., Gioia, M. di, Abinun, M., Alexander, T., Miniati, I., Gualandi, F., Fassas, A., Martin, T., Schwarze, C.P., Wulffraat, N., Buch, M., Sampol, A., Carreras, E., Dubois, B., Gruhn, B., Gungor, T., Pohlreich, D., Schuerwegh, A., Snarski, E., Snowden, J., Veys, P., Fasth, A., Lenhoff, S., Messina, C., Voswinkel, J., Badoglio, M., Henes, J., Launay, D., Tyndall, A., Gluckman, E., Farge, D., EBMT Autoimmune Disease Working, Department of Rheumatology, University Hospital Basel [Basel], Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Haematology Department, Careggi University Hospital, Newcastle General Hospital, Department of Rheumatology & Clinical Immunology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Biomedicine, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Department of Haematology II, Ospedale San Martino, Neurology & Haematology, George Papanicolau Hospital, Immunologie et chimie thérapeutiques (ICT), Cancéropôle du Grand Est-Centre National de la Recherche Scientifique (CNRS), Paediatric Haematology & Endocrinology, University Children's Hospital, University Medical Center, VU University Medical Center [Amsterdam], Section of Musculoskeletal Disease, University of Leeds, Hospital Universitari Son Espases, Department of Hematology, Hospital Clinic Barcelona, Department of Neurology, University Hospitals Leuven [Leuven], Department of Pediatrics, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Division of Immunology/Hematology/BMT, Charles University Hospital, Leiden University Medical Center (LUMC), Department of Hematology & Oncology, Medical University of Warsaw - Poland, Department of Haematology & Department of Oncology, NHS & University of Sheffield, Great Ormond Street Hospital for Children [London] (GOSH), University of Gothenburg (GU), University Hospital Lund, Dipartimento di Pediatria, Cinica di Oncoematologia Pediatrica, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Hematology & Rheumatology, University Hospital Tübingen, Department of Internal Medicine, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Clinical Research Unit, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie, dermatologie, oncologie, Oncodermatologie, immunologie et cellules souches cutanées (IDO (U976 / UMR_S 976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), EULAR Grant & Freiwillige Akademische Gesellschaft Basel, Università degli Studi di Firenze = University of Florence (UniFI), Universiteit Leiden-Universiteit Leiden, University of Sheffield [Sheffield], and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, stem-cell transplantation bone-marrow-transplantation hemolytic-anemia blood, medicine.medical_treatment, Hematopoietic stem cell transplantation, Biochemistry, Autoimmune thrombocytopenia, Antibodies, Monoclonal, Murine-Derived, 0302 clinical medicine, Prednisone, immune system diseases, Risk Factors, hemic and lymphatic diseases, Child, Hematopoietic Stem Cell Transplantation, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, Middle Aged, 3. Good health, Europe, surgical procedures, operative, Treatment Outcome, 030220 oncology & carcinogenesis, Child, Preschool, Rituximab, Female, Autoimmune hemolytic anemia, Immunosuppressive Agents, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Immunology, Autoimmune Diseases, 03 medical and health sciences, Young Adult, Antiphospholipid syndrome, Internal medicine, medicine, Humans, Immunologic Factors, Cyclophosphamide, Glucocorticoids, Retrospective Studies, Autoimmune disease, Lupus erythematosus, business.industry, Infant, Cell Biology, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, medicine.disease, Multivariate Analysis, business, 030215 immunology
Abstract

To specify the incidence and risk factors for secondary autoimmune diseases (ADs) after HSCT for a primary AD, we retrospectively analyzed AD patients treated by HSCT reported to EBMT from 1995 to 2009 with at least 1 secondary AD (cases) and those without (controls). After autologous HSCT, 29 of 347 patients developed at least 1 secondary AD within 21.9 (0.6-49) months and after allogeneic HSCT, 3 of 16 patients. The observed secondary ADs included: autoimmune hemolytic anemia (n = 3), acquired hemophilia (n = 3), autoimmune thrombocytopenia (n = 3), antiphospholipid syndrome (n = 2), thyroiditis (n = 12), blocking thyroid-stimulating hormone receptor antibody (n = 1), Graves disease (n = 2), myasthenia gravis (n = 1), rheumatoid arthritis (n = 2), sarcoidosis (n = 2), vasculitis (n = 1), psoriasis (n = 1), and psoriatic arthritis (n = 1). After autologous HSCT for primary AD, the cumulative incidence of secondary AD was 9.8% ± 2% at 5 years. Lupus erythematosus as primary AD, and antithymocyte globulin use plus CD34+ graft selection were important risk factors for secondary AD by multivariate analysis. With a median follow-up of 6.2 (0.54-11) years after autologous HSCT, 26 of 29 patients with secondary AD were alive, 2 died during their secondary AD (antiphospholipid syndrome, hemophilia), and 1 death was HSCT-related. This European multicenter study underlines the need for careful management and follow-up for secondary AD after HSCT.

Published
2011
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231. The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase‐1 antibodies

Author

Hunzelmann, N., primary, Riemekasten, G., additional, Becker, M.O., additional, Moinzadeh, P., additional, Kreuter, A., additional, Melchers, I., additional, Mueller‐Ladner, U., additional, Meier, F., additional, Worm, M., additional, Lee, H., additional, Herrgott, I., additional, Pfeiffer, C., additional, Fierlbeck, G., additional, Henes, J., additional, Juche, A., additional, Zeidler, G., additional, Mensing, H., additional, Günther, C., additional, Sárdy, M., additional, Burkhardt, H., additional, Koehm, M., additional, Kuhr, K., additional, Krieg, T., additional, and Sunderkötter, C., additional

Published
2016
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232. Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database

Author

Maurer, B. Graf, N. Michel, B.A. Müller-Ladner, U. Czirják, L. Denton, C.P. Tyndall, A. Metzig, C. Lanius, V. Khanna, D. Distler, O. Tarner, I.H. Cerinic, M.M. Guiducci, S. Walker, U. Lapadula, G. Iannone, F. Becvar, R. Sierakowsky, S. Bielecka, O.K. Cutolo, M. Sulli, A. Valentini, G. Cuomo, G. Vettori, S. Riemekasten, G. Rednic, S. Nicoara, I. Kahan, A. Allanore, Y. Vlachoyiannopoulos, P. Montecucco, C. Caporali, R. Carreira, P.E. Novak, S. Varju, C. Chizzolini, C. Kucharz, E.J. Kotulska, A. Kopec-Medrek, M. Widuchowska, M. Cozzi, F. Rozman, B. Mallia, C. Coleiro, B. Gabrielli, A. Farge, D. Hij, A. Airò, P. Hesselstrand, R. Scheja, A. Wollheim, F. Martinovic, D. Gurman, A.B. Braun-Moscovici, Y. Govoni, M. Monaco, A.L. Hunzelmann, N. Pellerito, R. Bambara, L.M. Caramaschi, P. Black, C. Damjanov, N. Henes, J. Santamaria, V.O. Heitmann, S. Krasowska, D. Seidel, M. Oleszowsky, M. Burkhardt, H. Himsel, A. Salvador, M.J. Stamenkovic, B. Stankovic, A. Tikly, M. Starovoytova, M.N. Ananieva, L.P. Scorza, R. Engelhart, M. Strauss, G. Nielsen, H. Damgaard, K. Szücs, G. Mendoza, A.Z. de la Puente Buijdos, C. Sifuentes Giraldo, W.A. Midtvedt, Ø. Garen, T. Hachulla, E. Launay, D. Valesini, G. Riccieri, V. Ionescu, R.M. Opris, D. Groseanu, L. Wigley, F.M. Mihai, C.M. Cornateanu, R.S. Ionitescu, R. Gherghe, A.M. Gorga, M. Dobrota, R. Bojinca, M. Schett, G. Distler, J.H.W. Meroni, P. Zeni, S. Mouthon, L. De Keyser, F. Smith, V. Cantatore, F.P. Corrado, A. Ullman, S. Iversen, L. Pozzi, M.R. Eyerich, K. Hein, R. Knott, E. Szechinski, J. Wiland, P. Szmyrka-Kaczmarek, M. Sokolik, R. Morgiel, E. Krummel-Lorenz, B. Saar, P. Aringer, M. Günther, C. Anic, B. Baresic, M. Mayer, M. Radominski, S.C. de Souza Müller, C. Azevedo, V.F. Agachi, S. Groppa, L. Chiaburu, L. Russu, E. Zenone, T. Stebbings, S. Highton, J. Stamp, L. Chapman, P. O’Donnell, J. Solanki, K. Doube, A. Veale, D. O’Rourke, M. Loyo, E. Li, M. Rosato, E. Pisarri, S. Tanaseanu, C.-M. Popescu, M. Dumitrascu, A. Tiglea, I. Chiriea and Maurer, B. Graf, N. Michel, B.A. Müller-Ladner, U. Czirják, L. Denton, C.P. Tyndall, A. Metzig, C. Lanius, V. Khanna, D. Distler, O. Tarner, I.H. Cerinic, M.M. Guiducci, S. Walker, U. Lapadula, G. Iannone, F. Becvar, R. Sierakowsky, S. Bielecka, O.K. Cutolo, M. Sulli, A. Valentini, G. Cuomo, G. Vettori, S. Riemekasten, G. Rednic, S. Nicoara, I. Kahan, A. Allanore, Y. Vlachoyiannopoulos, P. Montecucco, C. Caporali, R. Carreira, P.E. Novak, S. Varju, C. Chizzolini, C. Kucharz, E.J. Kotulska, A. Kopec-Medrek, M. Widuchowska, M. Cozzi, F. Rozman, B. Mallia, C. Coleiro, B. Gabrielli, A. Farge, D. Hij, A. Airò, P. Hesselstrand, R. Scheja, A. Wollheim, F. Martinovic, D. Gurman, A.B. Braun-Moscovici, Y. Govoni, M. Monaco, A.L. Hunzelmann, N. Pellerito, R. Bambara, L.M. Caramaschi, P. Black, C. Damjanov, N. Henes, J. Santamaria, V.O. Heitmann, S. Krasowska, D. Seidel, M. Oleszowsky, M. Burkhardt, H. Himsel, A. Salvador, M.J. Stamenkovic, B. Stankovic, A. Tikly, M. Starovoytova, M.N. Ananieva, L.P. Scorza, R. Engelhart, M. Strauss, G. Nielsen, H. Damgaard, K. Szücs, G. Mendoza, A.Z. de la Puente Buijdos, C. Sifuentes Giraldo, W.A. Midtvedt, Ø. Garen, T. Hachulla, E. Launay, D. Valesini, G. Riccieri, V. Ionescu, R.M. Opris, D. Groseanu, L. Wigley, F.M. Mihai, C.M. Cornateanu, R.S. Ionitescu, R. Gherghe, A.M. Gorga, M. Dobrota, R. Bojinca, M. Schett, G. Distler, J.H.W. Meroni, P. Zeni, S. Mouthon, L. De Keyser, F. Smith, V. Cantatore, F.P. Corrado, A. Ullman, S. Iversen, L. Pozzi, M.R. Eyerich, K. Hein, R. Knott, E. Szechinski, J. Wiland, P. Szmyrka-Kaczmarek, M. Sokolik, R. Morgiel, E. Krummel-Lorenz, B. Saar, P. Aringer, M. Günther, C. Anic, B. Baresic, M. Mayer, M. Radominski, S.C. de Souza Müller, C. Azevedo, V.F. Agachi, S. Groppa, L. Chiaburu, L. Russu, E. Zenone, T. Stebbings, S. Highton, J. Stamp, L. Chapman, P. O’Donnell, J. Solanki, K. Doube, A. Veale, D. O’Rourke, M. Loyo, E. Li, M. Rosato, E. Pisarri, S. Tanaseanu, C.-M. Popescu, M. Dumitrascu, A. Tiglea, I. Chiriea

Abstract

Objectives To identify predictive parameters for the progression of skin fibrosis within 1 year in patients with diffuse cutaneous SSc (dcSSc). Methods An observational study using the EUSTAR database was performed. Inclusion criteria were dcSSc, American College of Rheumatology (ACR) criteria fulfilled, modified Rodnan skin score (MRSS) ≥7 at baseline visit, valid data for MRSS at 2nd visit, and available follow-up of 12±2 months. Worsening of skin fibrosis was defined as increase in MRSS >5 points and ≥25% from baseline to 2nd visit. In the univariate analysis, patients with progressive fibrosis were compared with non-progressors, and predictive markers with p<0.2 were included in the logistic regression analysis. The prediction models were then validated in a second cohort. Results A total of 637 dcSSc patients were eligible. Univariate analyses identified joint synovitis, short disease duration (≤15 months), short disease duration in females/patients without creatine kinase (CK) elevation, low baseline MRSS (≤22/51), and absence of oesophageal symptoms as potential predictors for progressive skin fibrosis. In the multivariate analysis, by employing combinations of the predictors, 17 models with varying prediction success were generated, allowing cohort enrichment from 9.7% progressive patients in the whole cohort to 44.4% in the optimised enrichment cohort. Using a second validation cohort of 188 dcSSc patients, short disease duration, low baseline MRSS and joint synovitis were confirmed as independent predictors of progressive skin fibrosis within 1 year resulting in a 4.5-fold increased prediction success rate. Conclusions Our study provides novel, evidence-based criteria for the enrichment of dcSSc cohorts with patients who experience worsening of skin fibrosis which allows improved clinical trial design.

Published
2015

233. Low risk for digital ulcer development in SSc patients with increasing disease duration and lack of Scl-70 autoantibodies

Author

Hunzelmann, N., Moinzadeh, P., Riemekasten, G., Becker, M., Kreuter, A., Mueller-Ladner, U., Meier, F., Wozel, G., Melchers, I., Srdy, M., Sunderkoetter, C., Herrgott, I., Graefenstein, K., Zeidler, G., Fierlbeck, G., Pfeiffer, C., Worm, M., Lee, H., Burkhardt, H., Koehm, M., Henes, J., Mensing, H., Kuhr, K., Krieg, T., Hunzelmann, N., Moinzadeh, P., Riemekasten, G., Becker, M., Kreuter, A., Mueller-Ladner, U., Meier, F., Wozel, G., Melchers, I., Srdy, M., Sunderkoetter, C., Herrgott, I., Graefenstein, K., Zeidler, G., Fierlbeck, G., Pfeiffer, C., Worm, M., Lee, H., Burkhardt, H., Koehm, M., Henes, J., Mensing, H., Kuhr, K., and Krieg, T.

Published
2015

234. New data on scleroderma renal crisis and predictive factors from more than 3000 patients

Author

Moinzadeh, P, Riemekasten, G, Fierlbeck, G, Henes, J, Kötter, I, Kreuter, A, Lahner, N, Müller-Ladner, U, Melchers, I, Blank, N, Sunderkötter, C, Günther, C, Distler, JHW, Juche, A, Worm, M, Karrer, S, Simon, JC, Pfeiffer, C, Genth, E, Aberer, E, Steinbrink, K, Kuhn, A, Hein, R, Seitz, CS, Mensing, H, Lehmann, P, Sardy, M, Neeck, G, Fiehn, C, Weber, M, Goebeler, M, Kuhr, K, Krieg, T, Hunzelmann, N, Moinzadeh, P, Riemekasten, G, Fierlbeck, G, Henes, J, Kötter, I, Kreuter, A, Lahner, N, Müller-Ladner, U, Melchers, I, Blank, N, Sunderkötter, C, Günther, C, Distler, JHW, Juche, A, Worm, M, Karrer, S, Simon, JC, Pfeiffer, C, Genth, E, Aberer, E, Steinbrink, K, Kuhn, A, Hein, R, Seitz, CS, Mensing, H, Lehmann, P, Sardy, M, Neeck, G, Fiehn, C, Weber, M, Goebeler, M, Kuhr, K, Krieg, T, and Hunzelmann, N

Published
2015

239. SAT0440 New Data on Renal Crisis and Predictive Markers from More Than 3000 Patients

Author

Moinzadeh, P., primary, Riemekasten, G., additional, Fierlbeck, G., additional, Henes, J., additional, Blank, N., additional, Melchers, I., additional, Mueller-Ladner, U., additional, Kreuter, A., additional, Susok, L., additional, Guenther, C., additional, Zeidler, G., additional, Pfeiffer, C., additional, Worm, M., additional, Aberer, E., additional, Genth, E., additional, Distler, J.H., additional, Hein, R., additional, Sárdy, M., additional, Mensing, H., additional, Koetter, I., additional, Sunderkoetter, C., additional, Hellmich, M., additional, Krieg, T., additional, and Hunzelmann, N., additional

Published
2015
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240. SAT0056 Retro – Study of Reduction of Therapy in Patients with Rheumatoid Arthritis in Ongoing Remission

Author

Haschka, J., primary, Englbrecht, M., additional, Hueber, A.J., additional, Manger, B., additional, Kleyer, A., additional, Reiser, M., additional, Finzel, S., additional, Tony, H.-P., additional, Kleinert, S., additional, Feuchtenberger, M., additional, Fleck, M., additional, Manger, K., additional, Ochs, W., additional, Schmitt-Haendle, M., additional, Wendler, J., additional, Schuch, F., additional, Ronneberger, M., additional, Lorenz, H.-M., additional, Nuesslein, H., additional, Alten, R., additional, Demary, W., additional, Henes, J., additional, Schett, G., additional, and Rech, J., additional

Published
2015
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247. Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part I: Indications for fertility preservation.

Author

Schüring, A. N., Fehm, T., Behringer, K., Goeckenjan, M., Wimberger, P., Henes, M., Henes, J., Fey, M. F., and von Wolff, M.

Subjects
FERTILITY, CANCER in women, HODGKIN'S disease, GONADOTROPIN, BREAST cancer, LONGITUDINAL method, INDUCED ovulation, FERTILITY preservation
Abstract

Purpose: Most guidelines about fertility preservation are predominantly focused on scientific evidence, but are less practically orientated. Therefore, practically oriented recommendations are needed to support the clinician in daily practice.Methods: A selective literature search was performed based on the clinical and scientific experience of the authors, focussing on the most relevant diseases and gynaecological cancers. This article (Part I) provides information on topics that are essential for the fertility preservation indication, such as disease prognosis, disease therapy and its associated risks to fertility, recommending disease-specific fertility preservation measures. Part II specifically focusses on fertility preservation techniques.Results: In breast cancer patients, fertility preservation such as ovarian tissue and oocyte cryopreservation is especially recommended in low-stage cancer and in women < 35 years of age. In Hodgkin's lymphoma, the indication is mainly based on the chemotherapy regime as some therapies have very low, others very high gonadotoxicity. In borderline ovarian tumours, preservation of fertility usually is achieved through fertility sparing surgery, ovarian stimulation may also be considered. In cervical cancer, endometrial cancer, rheumatic diseases and other malignancies such as Ewing sarcoma, colorectal carcinoma, non-Hodgkin lymphoma, leukaemia etc., several other factors must be considered to enable an individual, stage-dependent decision.Conclusion: The decision for or against fertility preservation depends on the prognosis, the risks to fertility and individual factors such as prospective family planning. [ABSTRACT FROM AUTHOR]

Published
2018
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248. Varizella-Gastritis unter Immunsuppression.

Author

Saman, S., Henes, J.-C., Niepel, D., Bosmüller, H., Werner, C., Lauer, U., Malek, N., and Xenitidis, T.

Abstract

Copyright of Der Internist is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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249. SSc-overlap syndromes: a distinct clinical subgroup with significant differences in disease progression compared to lSSc and dSSc patients. Data of the German Network for Systemic Scleroderma (DNSS)

Author

Moinzadeh, P., Aberer, E., Ahmadi-Simab, K., Blank, N., Distler, J. W., Fierlbeck, G., Genth, E., Guenther, C., Hein, R., Henes, J., Herich, L., Herrgott, I., Koetter, I., Kreuter, A., Krieg, T., Kuhr, K., Lorenz, H. M., Meier, F., Melchers, I., Mensing, H., Mueller-Ladner, U., Pfeiffer, C., Riemekasten, G., Sardy, M., Schmalzing, M., Sunderkoetter, C., Susok, L., Tarner, I. H., Vaith, P., Worm, M., Zeidler, G., Hunzelmann, N., Moinzadeh, P., Aberer, E., Ahmadi-Simab, K., Blank, N., Distler, J. W., Fierlbeck, G., Genth, E., Guenther, C., Hein, R., Henes, J., Herich, L., Herrgott, I., Koetter, I., Kreuter, A., Krieg, T., Kuhr, K., Lorenz, H. M., Meier, F., Melchers, I., Mensing, H., Mueller-Ladner, U., Pfeiffer, C., Riemekasten, G., Sardy, M., Schmalzing, M., Sunderkoetter, C., Susok, L., Tarner, I. H., Vaith, P., Worm, M., Zeidler, G., and Hunzelmann, N.

Published
2014

250. ANALYSIS OF REAL LIFE VASOACTIVE THERAPY IN OVER 3000 PATIENTS WITH SYSTEMIC SCLEROSIS (SSC) REVEALS CONSIDERABLE UNDERTREATMENT AND SIGNIFICANT CHANGES OF TREATMENT PRACTICE SINCE 2004

Author

Moinzadeh, P., Elisabeth, A., Blank, N., Distler, J., Fierlbeck, G., Genth, E., Guenther, C., Hein, R., Henes, J., Hellmich, M., Herrgott, I., Koetter, I., Kreuter, A., Krieg, T., Melchers, I., Mensing, H., Mueller-Ladner, U., Pfeiffer, C., Riemekasten, G., Sardy, M., Susok, L., Worm, M., Wozel, G., Zeidler, G., Sunderkoetter, C., Hunzelmann, N., Moinzadeh, P., Elisabeth, A., Blank, N., Distler, J., Fierlbeck, G., Genth, E., Guenther, C., Hein, R., Henes, J., Hellmich, M., Herrgott, I., Koetter, I., Kreuter, A., Krieg, T., Melchers, I., Mensing, H., Mueller-Ladner, U., Pfeiffer, C., Riemekasten, G., Sardy, M., Susok, L., Worm, M., Wozel, G., Zeidler, G., Sunderkoetter, C., and Hunzelmann, N.

Published
2014

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