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A MAC mechanism was proposed based on network coding and link prediction for wireless sensor network. Firstly, an adaptive-window scheme was given based on EasiLQE which uses improved EWMA link quality estimation method and combines the methods of hardware and software, so the accuracy is increased.As a result of the instantaneous active detection, reaction rate became more rapid when unexpected situation was occurring in the network. Secondly, a MAC protocol was improved based on the existing MAC protocol. In the protocol improved, high-level secondary nodes around the path determined is increased by the routing module using the cast nature of wireless networks that al-ready exists rationally, so that significantly increased the network coding opportunity, without many problems caused by the concentrating flows. Finally, to seek a more appropriate balance between data diffusion and coding opportunities, the optimal factor was discussed. Experiment results show that this improved MAC protocol can increase network throughput and balance the load of the whole network effectively by using over-heard of nodes rationally, without causing concen-trating flows at the same time.

Abstract The homeodomain-leucine zipper (HD-Zip) gene family plays a pivotal role in plant development and stress responses. Nevertheless, a comprehensive characterization of the HD-Zip gene family in kiwifruit has been lacking. In this study, we have systematically identified 70 HD-Zip genes in the Actinidia chinensis (Ac) genome and 55 in the Actinidia eriantha (Ae) genome. These genes have been categorized into four subfamilies (HD-Zip I, II, III, and IV) through rigorous phylogenetic analysis. Analysis of synteny patterns and selection pressures has provided insights into how whole-genome duplication (WGD) or segmental may have contributed to the divergence in gene numbers between these two kiwifruit species, with duplicated gene pairs undergoing purifying selection. Furthermore, our study has unveiled tissue-specific expression patterns among kiwifruit HD-Zip genes, with some genes identified as key regulators of kiwifruit responses to bacterial canker disease and postharvest processes. These findings not only offer valuable insights into the evolutionary and functional characteristics of kiwifruit HD-Zips but also shed light on their potential roles in plant growth and development.

In this study, an ultrasound-assisted macroporous resin fixed-bed device was constructed for the purification of Aronia melanocarpa anthocyanins. Meanwhile, the effect of ultrasound on the mass transfer characteristics during the adsorption/desorption of anthocyanins on the fixed bed was investigated. The mass transfer patterns of total anthocyanins, total sugars, individual organic acids, individual anthocyaninic and non-anthocyaninic phenolics during fixed-bed purification were determined, and the effect of ultrasound on the physical properties of macroporous resins was analyzed. It was found that this fixed bed device could effectively remove impurities from the crude extract of A. melanocarpa. After purification, the purities of anthocyanin and polyphenol were 48.8% and 78.7%, respectively. During adsorption, ultrasound promoted the release of anthocyanins from the fixed bed. Specifically, in the fixed bed with a height of 2.5 cm, the breakthrough time of anthocyanin adsorption was reduced by 65.8% under sonication at 18.76 W/cm2. Moreover, the mass transfer during anthocyanin desorption using a highly polar eluent was enhanced by ultrasound. When 25% aqueous ethanol was used as the desorption solvent, the amount of anthocyanins desorbed from the fixed bed after 48 min of elution was increased by 12.6% by 18.76 W/cm2 ultrasound. Besides, ultrasound significantly increased the surface roughness of macroporous resin particles, but did not change the interior structure. In summary, ultrasound-assisted fixed bed treatment significantly improves the flowing of anthocyanins among resin particles during the adsorption/desorption, but has little effect on the interaction between single resin particles and anthocyanins.

Objective The common differentially expressed mRNAs in brain, heart and liver tissues of deceased sudden infant death syndrome （SIDS） and infectious sudden death in infancy （ISDI） confirmed by autopsy was screened by bioinformatics to explore the common molecular markers and pathogenesis of SIDS and ISDI. Methods The datasets of GSE70422 and GSE136992 were downloaded, the limma of R software was used to screen differentially expressed mRNA in different tissue samples of SIDS and ISDI decedents for overlapping analysis. The clusterProfiler of R software was used to conduct gene ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis. The protein-protein interaction （PPI） network was constructed by STRING database, while the hub gene was screened by cytoHubba plug-in. Results Compared with the control group, there were 19 significant differentially expressed genes in the tissue samples of SIDS and ISDI decedents, among which 16 in the heart tissue and 3 in the liver tissue, and the astrotactin 1 （ASTN1） gene expression difference in the heart tissue was most significant. The PPI network identified Ras homolog family member A （RHOA）, integrin subunit alpha 1 （ITGA1）, and H2B clustered histone 5 （H2BC5） were hub genes. The analysis of GO and KEGG showed that differentially expressed genes were enriched in the molecular pathways of actin cytoskeleton regulation, focal adhesion and response to mycophenolic acid. Conclusion ASTN1, RHOA and ITGA1 may participate in the development of SIDS and ISDI. The enrichment of differentially expressed genes in immune and inflammatory pathways suggests a common molecular regulatory mechanism between SIDS and ISDI. These findings are expected to provide new biomarkers for molecular anatomy and forensic identification of SIDS and ISDI.

El cáncer gástrico es la principal causa de muerte por cáncer enColombia y su incidencia está en aumento y en especial los casos enetapa avanzada. Este estudio analizó la evolución postquirúrgica de 31 pacientes con cáncer gástrico temprano (CGT) en seis diferentes instituciones hospitalarias de Medellín, entre enero de 1994 y diciembre de 2000.

Introduction: Irisin is a newly discovered myokine which links exercise to inflammation and inflammation-related diseases through macrophage regulation. However, the effect of irisin on the activity of inflammation related immune cells (such as neutrophils) has not been clearly described. Objectives: The objective of our study was to explore the effect of irisin on the neutrophil extracellular traps (NETs) formation. Methods: Phorbol-12-myristate-13-acetate (PMA) was used to construct a classic neutrophil inflammation model that was used to observe the formation of NETs in vitro. We studied the effect of irisin on NETs formation and its regulation mechanism. Subsequently, acute pancreatitis (AP) was used to verify the protective effect of irisin in vivo, which was an acute aseptic inflammatory response disease model closely related to NETs. Results: Our study found that addition of irisin significantly reduced the formation of NETs via regulation of the P38/MAPK pathway through integrin αVβ5, which might be the one of key pathways in NETs formation, and which could theoretically offset the immunoregulatory effect of irisin. Systemic treatment with irisin reduced the severity of tissue damage common in the disease and inhibited the formation of NETs in pancreatic necrotic tissue of two classical AP mouse models. Conclusion: The findings confirmed for the first time that irisin could inhibit NETs formation and protect mice from pancreatic injury, which further elucidated the protective effect of exercise on acute inflammatory injury.

Abstract Aim To explore whether self‐efficacy has any positive or negative mediating effects between family functioning and quality of life among elders with chronic diseases. Design A cross‐sectional study. Methods Questionnaires were collected from 516 community‐dwelling elderly individuals with chronic diseases using a convenience sampling method. The questionnaires included the Self‐efficacy for Managing Chronic Disease Six‐Item Scale, the Family Adaptation Partnership Growth Affection Resolve Index and the MOS 36‐Item Short Form Health Survey. Results Family functioning and self‐efficacy impacted the quality of life of community‐dwelling elderly individuals with chronic diseases. Family functioning was mediated by self‐efficacy and had an indirect impact on quality of life. The mediating effect accounted for 62.50% of the total effect.

In the title compound, C25H21F2N3O5, the quinoline unit is almost planar, with a maximum deviation of 0.076 (2) Å. The quinoline plane makes dihedral angles of 53.94 (5) and 85.79 (5)° with the pyrimidine and benzene rings, respectively. In the crystal structure, intermolecular C—H⋯O hydrogen bonds form a centrosymmetric dimer. The ethyl group is disordered over two positions, with occupancy factors of 0.778 (16) and 0.222 (16). [ABSTRACT FROM AUTHOR]

Abstract Aim The study was to explore the significant influence of an English nursing course in nursing postgraduate internationalization education. Design A cross‐sectional study. Method The research object included three grades (a total of 18) of nursing postgraduate students in the Nursing School of Yangzhou University. A standardized four‐section questionnaire designed by the authors was applied to the survey. Results 88.89% were satisfied with the course design and application of the English nursing course, and the scores for all 6 items were above the average, but only 44.4% of the postgraduate students understood the course completely. In teaching design and content aspect, 88.9%–94.4% postgraduate nurses felt that the course learning requirements were clear and could improve their knowledge and capacity for scientific research. All of the postgraduate nurses were identified with the teacher's moral and academic characters. Conclusions To establish English nursing courses for nursing postgraduate students is beneficial for postgraduate internationalization education.

This study investigated the effect of a novel progestin and its combination with metformin on the growth of endometrial cancer (EC) cells. Inhibitory effects of four progestins, including nomegestrol acetate (NOMAC), medroxyprogesterone acetate, levonorgestrel, and cyproterone acetate, were evaluated in RL95-2, HEC-1A, and KLE cells using cell counting kit-8 assay. Flow cytometry was performed to detect cell cycle and apoptosis. The activity of Akt (protein kinase B), mTOR (mammalian target of rapamycin) and its downstream substrates 4EBP1 (4E-binding protein 1) and eIF4G (Eukaryotic translation initiation factor 4G) were assayed by Western blotting. Nude mice were used to assess antitumor effects in vivo. NOMAC inhibited the growth of RL95-2 and HEC-1A cells, accompanied by arresting the cell cycle at G0/G1 phase, inducing apoptosis, and markedly down-regulating the level of phosphorylated mTOR/4EBP1/eIF4G in both cell lines (p < 0.05). Metformin significantly increased the inhibitory effect of and apoptosis induced by NOMAC and strengthened the depressive effect of NOMAC on activity of mTOR and its downstream substrates, compared to their treatment alone (p < 0.05). In xenograft tumor tissues, metformin (100 mg/kg) enhanced the suppressive effect of NOMAC (100 mg/kg) on mTOR signaling and increased the average concentration of NOMAC by nearly 1.6 times compared to NOMAC treatment alone. Taken together, NOMAC suppressing the growth of EC cells likely correlates to down-regulating the activity of the mTOR pathway and metformin could strengthen this effect. Our findings open a new window for the selection of progestins in hormone therapy of EC.

Objective: To explore the possible relationship between recurrent aphthous ulcer (RAU) and single nucleotide polymorphism (SNP) of transforming growth factor-β1 (TGF-β1)-509T/C and interleukin-10 (IL-10)-1082A/G sites., Methods: A total of 138 RAU patients were recruited for this study. The control group consisted of 124 subjects. TGF-β1-509T/C and IL-10-1082A/G sites were detected by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) and sequence specific primer-polymerase chain reaction (SSP-PCR). Relative risk ratios were estimated by odds ratios (OR) and 95% confidence interval (95%CI)., Results: Significant differences were found in the genotype frequencies or allele frequencies of TGF-β1-509T/C and IL-10-1082A/G sites between the RAU patients and controls (P < 0.05). CT genotype (OR = 1.231, 95% CI = 0.702-2.160), TT genotype (OR = 2.482, 95% CI = 1.250-4.927), and T allele (OR = 1.465, 95% CI = 1.036-2.074) at the TGF-β1-509 site exhibited high risks. AG genotype (OR = 1.391, 95% CI = 0.808-2.396), GG genotype (OR = 4.165, 95% CI = 1.944-8.924), and G allele (OR = 2.134, 95% CI = 1.474-3.089) at the IL-10-1082A/G site also showed high risks., Conclusion: TGF-β1-509T/C and IL-10-1082A/G sites are associated with the risk of RAU. The TGF-β1 gene-509T allele and IL-10 gene-1082G allele may serve as genetic determinants for RAU.