201. Lack of efficacy of Haemophilus b polysaccharide vaccine in Minnesota.
- Author
-
Osterholm MT, Rambeck JH, White KE, Jacobs JL, Pierson LM, Neaton JD, Hedberg CW, MacDonald KL, and Granoff DM
- Subjects
- Bacterial Capsules, Child, Preschool, Epidemiologic Methods, Female, Haemophilus influenzae, Humans, Male, Minnesota, Population Surveillance, Random Allocation, Statistics as Topic, Time Factors, Bacterial Vaccines administration & dosage, Haemophilus Infections prevention & control, Haemophilus Vaccines, Polysaccharides, Bacterial
- Abstract
We evaluated the efficacy of Haemophilus b polysaccharide vaccine in children in Minnesota using a case-control study. The vaccine became available in Minnesota in August 1985. During the subsequent 28 months, 88 cases of invasive H influenzae type b disease were identified in children 24 to 71 months of age, the group targeted for vaccination. Of the 88 cases, 36 (41%) occurred in vaccinated children. Fifty-eight (33%) of 176 controls were vaccinated during a similar period. The vaccine's protective efficacy for children with any history of vaccination was -58% (95% confidence interval = -204% to 18%). The vaccine's protective efficacy for children who were most likely to be protected by vaccination was -55% (95% confidence interval = -238% to 29%). Our results indicate that vaccination with Haemophilus b polysaccharide vaccine had no effect in preventing H influenzae type b disease in Minnesota children.
- Published
- 1988