988 results on '"Jae-Woo Park"'
Search Results
202. Lorentz force promoted charge separation in a hierarchical, bandgap tuned, and charge reversible NixMn(0.5−x)O photocatalyst for sulfamethoxazole degradation
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Jae-Woo Park and Hassan Anwer
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History ,Materials science ,Polymers and Plastics ,Band gap ,Process Chemistry and Technology ,chemistry.chemical_element ,Nanoparticle ,Electron ,Industrial and Manufacturing Engineering ,Catalysis ,chemistry ,Chemical engineering ,Oxidation state ,Photocatalysis ,Charge carrier ,Business and International Management ,Platinum ,General Environmental Science - Abstract
Here, a hierarchical NixMn(0.5−x)O catalyst that propels charge carriers to opposite interfaces of core@shell nanoparticle is reported. The opposite drift of charge carriers was achieved by tuning band edges in a multilevel catalyst by varying the molar concentration (x, 0→0.5) of precursors in a series of input injections. Preferential oxidation by holes on the surface of the catalyst was confirmed with the oxidation state transformation of metal ions (platinum and lead) deposited on the catalyst from their respective solutions. To obtain an electron rich surface, the synthesis scheme was reversed (x, 0.5→0), which yielded a catalyst with an inverse geometry and directed electron flow towards the surface. The collective impact of the Lorentz force and internal charge carrier drift contributed to excellent recombination suppression and 98% sulfamethoxazole degradation in 30 min. Finally, structural integrity and catalytic potential of the composite after repeated magnetic separation and degradation cycles was assessed to establish its practical applicability.
- Published
- 2022
203. Effects of Onchung-eum, an Herbal Prescription, on 5-Fluorouracil–Induced Oral Mucositis
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Jinsung Kim, Mun Seog Chang, Jae-Woo Park, Seok-Jae Ko, and Jayoung Oh
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Male ,0301 basic medicine ,side effect ,Side effect ,Cell Survival ,Herbal Medicine ,medicine.medical_treatment ,Hamster ,Pharmacology ,chemotherapy ,03 medical and health sciences ,0302 clinical medicine ,Cheek pouch ,medicine ,Mucositis ,Animals ,Humans ,5-fluorouracil ,Viability assay ,Research Articles ,Inflammation ,Stomatitis ,Chemotherapy ,TUNEL assay ,Cell Death ,Mesocricetus ,Plant Extracts ,business.industry ,NF-kappa B ,Onchung-eum ,medicine.disease ,030104 developmental biology ,Complementary and alternative medicine ,Oncology ,herb ,Fluorouracil ,030220 oncology & carcinogenesis ,Quality of Life ,Cytokines ,Reactive Oxygen Species ,business ,oral mucositis ,medicine.drug - Abstract
In most cancer patients, chemotherapy-induced oral mucositis (OM) is a frequent side effect, leading to low quality of life and delay in therapy. The aim of this study was to evaluate the effects of Onchung-eum, a well-known herbal prescription in traditional medicine comprising 8 herbs that has long been used for skin diseases, on 5-fluorouracil (5-FU)–induced OM in human pharyngeal cells and golden Syrian hamsters. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and reactive oxygen species production were measured in vitro. The effects of Onchung-eum on OM of hamster cheek pouches induced by 5-FU were evaluated histologically and using TUNEL assay. In addition, the expression of nuclear factor-κB, caspase-3, and pro-inflammatory cytokines were measured by immunoblotting and immunohistochemistry. Significantly increased cell viability was observed in the Onchung-eum–treated groups compared with the 5-FU–treated control group. In 500 and 1000 mg/kg Onchung-eum–treated groups, the damaged epithelial layers in the cheek pouches of hamsters were significantly recovered. Moreover, at all concentrations, cell death in the cheek pouches of hamsters in the Onchung-eum–treated groups significantly decreased. The expression of pro-inflammatory cytokines, nuclear factor-κB, and caspase-3 also significantly decreased in Onchung-eum–treated groups at 500 and 1000 mg/kg. In conclusion, this study revealed that Onchung-eum can be used to treat chemotherapy-induced OM. However, further studies are required to understand the underlying mechanisms.
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- 2018
204. Effects of Dangguisusan, a prescription of Korean medicine on controlled cortical impact-induced traumatic brain injury mouse model
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Kyungjin Lee, Jae-Woo Park, Jinhyun Bae, Youngmin Bu, Jae-Heung Cho, Yumi Bang, Beom-Joon Lee, Hyejin Joo, and Jae-Young Jung
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Male ,Oncology ,medicine.medical_specialty ,Traumatic brain injury ,Brain damage ,Hippocampal formation ,Body weight ,Hippocampus ,Motor function ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Brain Injuries, Traumatic ,Drug Discovery ,medicine ,Animals ,Novel object recognition ,Neurons ,Pharmacology ,Mice, Inbred ICR ,Behavior, Animal ,Plant Extracts ,business.industry ,030208 emergency & critical care medicine ,Cognition ,medicine.disease ,Disease Models, Animal ,Neuroprotective Agents ,Traumatic injury ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Ethnopharmacological relevance Dangguisusan (DGSS) is a widely used prescription for the treatment of traumatic injury in Korean medicine. Aim of the study To demonstrate the effects of DGSS on a mouse model of traumatic brain injury (TBI) for providing scientific evidence in clinical use. Materials and methods TBI was induced in a mouse model using the controlled cortical impact method. Water extract of DGSS (50, 150, and 450 mg/kg) was administered twice a day for 8 d. Histological analyses were performed 8 d after TBI. Moreover, beam-walking, grip-strength, and novel object recognition (NOR) tests were conducted to evaluate the effects on motor function, muscle strength, and cognitive memory function, respectively. Result DGSS inhibited body weight loss, hippocampal damage, and neuronal loss in the thalamic region. Furthermore, it reduced transverse time and foot faults in the beam-walking test at 3 d and increased the muscle strength in the grip-strength test at 3 and 8 d. It also improved the recognition index (%) in the NOR test. However, DGSS did not show protective effects against total damage. Conclusions DGSS might improve sensory–motor and cognitive functions after TBI with partial protective effects against brain damage. The present findings provide a scientific basis for the clinical use of DGSS in TBI.
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- 2018
205. Study on the Possibility of Quantitative Measurement of Abdominal Examinations in Korean Medicine - A Focus on Diagnosis of Abdominal Coldness in Functional Dyspepsia Patients
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Jae-hong Lee, Soo-ho Cho, Jin Sung Kim, Seok-Jae Ko, and Jae-Woo Park
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03 medical and health sciences ,Focus (computing) ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Oral temperature ,Abdominal examination ,General surgery ,Medicine ,030211 gastroenterology & hepatology ,business ,030205 complementary & alternative medicine - Published
- 2018
206. Trends of Tongue Features in Functional Dyspepsia Patients
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Seok Jae Ko, Jihye Kim, Keun Ho Kim, and Jae-Woo Park
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03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,business.industry ,Tongue ,030220 oncology & carcinogenesis ,Medicine ,Dentistry ,Tongue coating ,business ,030205 complementary & alternative medicine - Published
- 2018
207. Correlation Analysis between Gastric Emptying Measurement by Ultrasonography and Korean Medical Questionnaires
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Jae-hong Lee, Jae-Woo Park, Seok Jae Ko, Soo-ho Cho, and Jin Sung Kim
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Gastric emptying ,business.industry ,030220 oncology & carcinogenesis ,Abdominal examination ,Correlation analysis ,medicine ,030211 gastroenterology & hepatology ,Radiology ,Ultrasonography ,business - Published
- 2018
208. Arthroscopic Excision of Delayed Diagnosed Intra-articular Osteoid Osteoma of the Elbow: A Case Report
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Ho Dong Na, Joon Hyuk Choi, Duk Seop Shin, Sam Guk Park, and Jae Woo Park
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musculoskeletal diseases ,Osteoid osteoma ,medicine.medical_specialty ,Radiography ,Geography, Planning and Development ,Elbow ,Intra-articular osteoid osteoma ,Case Report ,Management, Monitoring, Policy and Law ,Elbow pain ,030218 nuclear medicine & medical imaging ,Lesion ,Arthroscopy ,03 medical and health sciences ,0302 clinical medicine ,Intra articular ,medicine ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,musculoskeletal system ,medicine.disease ,Surgery ,body regions ,medicine.anatomical_structure ,medicine.symptom ,business ,Range of motion - Abstract
An intra-articular osteoid osteoma is a very rare cause of elbow pain, and its diagnosis and treatment remain challenging. Delayed diagnosis may lead to arthritic change of the joint. In this study, the authors present the occurrence of intra-articular osteoid osteoma in the right elbow of a 15-year-old male patient who presented with prolonged pain and limited motion owing to delayed diagnosis. After confirming the nidus of osteoid osteoma from radiographic evaluation, the lesion was completely removed arthroscopically. The patient presented a complete relief of symptoms and full range of motion. This is the first domestic report of successful arthroscopic treatment of an intra-articular osteoid osteoma of the elbow.
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- 2018
209. Synthesis and characterization of a heterojunction rGO/ZrO2/Ag3PO4 nanocomposite for degradation of organic contaminants
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Jae-Woo Park and Hassan Anwer
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Environmental Engineering ,Materials science ,Nanocomposite ,Graphene ,Health, Toxicology and Mutagenesis ,Silver phosphate ,Oxide ,Quantum yield ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Pollution ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Adsorption ,chemistry ,Chemical engineering ,law ,Photocatalysis ,Environmental Chemistry ,Degradation (geology) ,0210 nano-technology ,Waste Management and Disposal - Abstract
Synergy between surface adsorption and photocatalysis is key for effective contaminant degradation in the liquid phase. Herein, we report a heterojunction photocatalyst of reduced graphene oxide (rGO)/zirconium dioxide (ZrO2)/silver phosphate (Ag3PO4) that incorporates this synergy for 4-nitrophenol (PNP) removal. Compared with other photocatalyst combinations, ZrO2 and Ag3PO4 coupling generates reactive species with greater degradation potential. ZrO2 and rGO were synthesized by a green approach using a one-step hydrothermal reaction in ethanol–water. The growth of rGO/ZrO2 and Ag3PO4 were accomplished and the functions of each part were well developed together. The rGO/ZrO2/Ag3PO4 composite exhibited enhanced light absorption and a low band gap energy (2.3 eV) owing to rGO and Ag3PO4 integration. The composite’s photocatalytic activity was much higher than that of ZrO2, Ag3PO4, or ZrO2/Ag3PO4. The maximal adsorption of PNP was 26.88 mg/g, and a pseudo-first-order model described the PNP degradation kinetics (k = 0.034 min−1). Synergy between the three components resulted in 97% PNP removal in 90 min, and even after five cycles, 94% PNP removal was obtained. The quantum yield of the system (7.31 × 10−5 molecules/photon) was compared with those in previous reports to assess the photocatalytic performance and energy requirements.
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- 2018
210. The efficacy and safety of Ojeok-san plus Saengmaek-san for gastro-esophageal reflux-induced chronic cough: a protocol for a pilot, randomized, double-blind, placebo-controlled trial
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Yeon Hee Bhang, Kwan-Il Kim, Jaehyo Kim, Junmo Ahn, Hwan-Su Jung, Changsop Yang, Seok-Jae Ko, Youngmin Bu, Jae-Woo Park, Kyoung Sun Park, Hee-Jae Jung, Jun-Hwan Lee, and Beom-Joon Lee
- Subjects
digestive system diseases - Abstract
Background Gastro-esophageal reflux disease (GERD) is a major cause of chronic cough. GERD-induced chronic cough is difficult to diagnose because some patients do not complain of any gastrointestinal (GI) reflux symptoms. Although chronic cough due to GERD is highly prevalent, no effective treatment is currently available, especially for GERD-related cough without GI symptoms. As the herbal medicines Ojeok-san and Saengmaek-san can effectively treat GERD and cough, we aim to evaluate the efficacy and safety of a combination of these components for relieving chronic cough due to GERD. Methods This is a study protocol of a randomized, double-blind, placebo-controlled, single-center pilot trial. After one-week run-in period, a total of 30 patients with GERD-induced chronic cough will be randomly allocated to an intervention group (n=15) or placebo group (n=15). Participants will receive 5.76 g of Ojeok-san plus Saengmaek-san or a placebo three times per day for 6 weeks. The primary outcome measures, the frequency and severity of cough, will be recorded using a cough diary. The secondary outcome measures will include a cough visual analog scale, the Leicester Cough Questionnaire (Korean version), Gastrointestinal Symptom Rating Scale, Hull Airway Reflux (hypersensitivity) Questionnaire, Pattern Identification for Chronic Cough Questionnaire, Pattern Identification for Gastroesophageal Reflux Disease, and safety testing. Adverse events will also be reported. Discussion This will be the first clinical trial to explore herbal medicines for the GERD-related chronic cough, including patients without GI reflux symptoms. This study will provide useful evidence regarding the efficacy and safety of Ojeok-san plus Saengmaek-san treatment. In addition, this trial will offer scientific basis for the combination of herbal medicines. This finding will also serve as an important data for conducting a larger-scale clinical trial on GERD-induced chronic cough. Trial registration This trial has been registered with Clinical Research Information Service (CRIS) of South Korea (http://cris.nih.go.kr; registration number: KCT0003115). Registered August 28, 2018.
- Published
- 2019
211. Silylation of sodium silicate-based silica aerogel using trimethylethoxysilane as alternative surface modification agent
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Jae Woo Park, Chang Hyun Lim, Yang Seo Ku, Taehee Kim, Kyu Yeon Lee, Hyung Ho Park, Ji Yeon Seo, Ha Yoon Nah, Haryeong Choi, and Vinayak G. Parale
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Materials science ,Silylation ,Aerogel ,Sodium silicate ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Contact angle ,chemistry.chemical_compound ,Surface-area-to-volume ratio ,Chemical engineering ,chemistry ,Specific surface area ,Materials Chemistry ,Ceramics and Composites ,Surface modification ,0210 nano-technology ,Porosity - Abstract
Trimethylethoxysilane (TMES) has been recognized as a good co-precursor to increase the degree of hydrophobicity during the synthesis of a silica aerogel because of its methyl groups. Therefore, some physical properties of silica aerogels, including the contact angle and porosity, were investigated using TMES as a co-precursor at different molar ratios with the main precursor such as tetramethoxysilane (TMOS) or tetraethoxysilane (TEOS). In contrast to TMES, most silylating agents such as hexamethyldisilazane (HMDZ) and trimethylchlorosilane (TMCS) have been used for surface modification because of their ability to enhance the hydrophobicity of the aerogel surface. This work examines the silylation effect, which includes increasing hydrophobicity by TMES to determine the possibility of using it as an alternative silylating agent during ambient pressure drying in the synthesis of sodium silicate-based silica aerogel. In addition, the physical properties of sodium silicate-based silica aerogels with silylation under different TMES/TMCS volume ratio are investigated. The physical properties of sodium silicate-based aerogels can be changed by the TMES/TMCS volume ratio during the surface modification step. Aerogels with a high specific surface area (458 m2/g), pore volume (3.215 cm3/g), porosity (92.7%), and contact angle (131.8°) can be obtained TMES/TMCS volume ratio of 40/60.
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- 2018
212. Disscussion on the Expansion and Significance of Lee Younghee’s Idea of Lu Xun Studies
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Jae Woo Park
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- 2018
213. Analysis of the natural radioactivity concentrations of the fine dust samples in Jeju Island, Korea and the annual effective radiation dose by inhalation
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Jae Woo Park and Chung Hun Han
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010504 meteorology & atmospheric sciences ,Health, Toxicology and Mutagenesis ,Potassium ,chemistry.chemical_element ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Concentration ratio ,Article ,Analytical Chemistry ,PM10 ,Mass concentration (chemistry) ,Radiology, Nuclear Medicine and imaging ,Jeju ,Spectroscopy ,Natural radioactivity ,0105 earth and related environmental sciences ,Inhalation ,Asian Dust ,Public Health, Environmental and Occupational Health ,Thorium ,Uranium ,Pollution ,0104 chemical sciences ,Fine dust ,Nuclear Energy and Engineering ,chemistry ,Environmental chemistry - Abstract
This study analyzed the concentrations of potassium, thorium and uranium of the atmospheric PM10 aerosols which were collected at Gosan of Jeju Island during the year of 2014. The mean mass concentration of PM10 was 47.31 μg/m3. The mean radioactive concentrations of 40K, 232Th and 238U were 7.89, 0.25 and 0.30 μBq/m3, respectively. The 232Th/238U activity concentration ratio of PM10 was 0.830. The 232Th/238U ratio during Asian Dust days is 1.073, which is higher than those in other atmospheric conditions. The concentration ratio of 232Th/238U was 0.902 in China continent.
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- 2018
214. Morphological changes of vertebral compression fracture with intra-vertebral cleft treated with percutaneous vertebroplasty
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Sang Min Park, Jin S. Yeom, Jae Woo Park, Boon-Soon Chang, Choon Ki Lee, Hyoungmin Kim, and Ho Joong Kim
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Male ,medicine.medical_specialty ,Radiography ,medicine.medical_treatment ,Risk Assessment ,030218 nuclear medicine & medical imaging ,Cohort Studies ,Percutaneous vertebroplasty ,03 medical and health sciences ,0302 clinical medicine ,Fractures, Compression ,medicine ,Back pain ,Humans ,Minimally Invasive Surgical Procedures ,Orthopedics and Sports Medicine ,Aged ,Pain Measurement ,Retrospective Studies ,Aged, 80 and over ,Vertebroplasty ,Cementoplasty ,business.industry ,Vertebral compression fracture ,Retrospective cohort study ,Middle Aged ,Prognosis ,Compression (physics) ,medicine.disease ,Magnetic Resonance Imaging ,Posterior column ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Spinal Fractures ,Female ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Osteoporotic Fractures ,030217 neurology & neurosurgery ,Vertebral column - Abstract
Background Vertebroplasty represents an established treatment option for osteoporotic vertebral compression fracture (OVCF), but its radiographic and clinical outcomes have not been clearly described in patients with intra-vertebral cleft (IVC). The aim of this study was to assess vertebral height restoration, recollapse and change of back pain in OVCF patients with or without IVC. Methods The records of 108 patients with IVC (group I) and 233 patients without IVC (group II) were included in our analysis between March 2001 and February 2014. The heights of the anterior, middle, and posterior columns, as well as the wedge angle (WA) of the fractured vertebral body were measured. For each vertebral column, the mean height of the superior and inferior vertebral body served as reference. Pre-operative, postoperative, and final compression rates (CR), as well as restoration and recollapse rates were calculated for each column. Subjective back pain was assessed as the numeric rating scale (NRS) score. Results The overall incidence of IVC in OVCF patients who underwent vertebroplasty was 20.8% (127/611 patients). Group I showed significantly higher CR over the entire follow-up period, with the exception of CR for the anterior column at final follow-up, and CR for the posterior column throughout the follow-up. The mean restoration rates at the anterior and middle column immediately after vertebroplasty were also significantly larger in group I. Recollapse rate in all columns was similar for groups I and II. The mean wedge angle was significantly larger in group I over the entire follow-up period. The groups did not differ in terms of NRS score at final follow-up. Conclusions Vertebroplasty restores vertebral body heights and WA more effectively in OVCF patients with IVC, and provides satisfactory radiographic and clinical outcomes regardless of the presence of IVC.
- Published
- 2018
215. Evaluation of Results in Pesticide Residues on Incongruity Commercial Agricultural Commodities using Network Analysis Method
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Jae Woo Park, Man Jae Bae, Kang In Na, Jun Ho Seo, Dong Hun Lee, and Sung Yong Cho
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0301 basic medicine ,03 medical and health sciences ,Agricultural science ,Agricultural commodity ,030109 nutrition & dietetics ,Pesticide residue ,010401 analytical chemistry ,Environmental science ,01 natural sciences ,0104 chemical sciences - Published
- 2018
216. Development and validation of a new pattern identification scale for Stomach Qi Deficiency
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Seok-Jae Ko, Jinsung Kim, Jaehyung Lee, and Jae-Woo Park
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medicine.medical_specialty ,Receiver operating characteristic ,business.industry ,Stomach ,Delphi method ,Construct validity ,Gastroenterology ,030205 complementary & alternative medicine ,Pattern identification ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Complementary and alternative medicine ,Cronbach's alpha ,Internal medicine ,Scale (social sciences) ,medicine ,030212 general & internal medicine ,business ,Reliability (statistics) ,Clinical psychology - Abstract
Introduction This study aimed to develop pattern identification scale for Stomach Qi Deficiency (SSQD) and investigated whether this questionnaire satisfied adequate reliability and validity. Methods To develop SSQD, we extracted major symptoms of Stomach Qi Deficiency (SQD) syndrome and requested an expert group to take part in a Delphi survey. The questionnaire was modified by the opinion of the expert group. For the analysis of reliability and validity and investigation of cut-off value, 30 participants who had dyspepsia and diagnosed as SQD and 30 healthy control participants were evaluated. Results Of the 13 questions in the SSQD, 1 question had negative effects on reliability and validity, therefore, it was excluded on further inspection. Overall Cronbach’s α coefficient of SSQD was 0.87. Construct validity was analyzed by factor analysis resulting 3 major factors. Using receiver operating characteristic curve analysis, the optimal cut-off value of SSQD was defined as 14, and its sensitivity and specificity were 93.33% and 86.67%, respectively. There were statistically significant positive correlation between SSQD and other dyspepsia severity scales. Conclusions The newly developed SSQD can provide fundamental reliability and validity as a specific pattern diagnosis questionnaire and can help diagnosing SQD. However, further studies will be needed to further confirm its specificity.
- Published
- 2018
217. Case Series of Refractory Gastroesophageal Reflux Disease Treated with Lijin-tang-gamibang
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Gajin Han, Jin Sung Kim, Seok-Jae Ko, Na-Yeon Ha, Dae-jun Kim, and Jae-Woo Park
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medicine.medical_specialty ,business.industry ,Reflux ,Disease ,medicine.disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,GERD ,030211 gastroenterology & hepatology ,business - Published
- 2017
218. Psychomotor as a practical plan for revitalization of self-determining activities: Focusing on Psychomotor case analysis according to Walther's educational anthropology aspect
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Jae Woo Park
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Psychomotor learning ,Self-determination ,media_common.quotation_subject ,Mathematics education ,Plan (drawing) ,Psychology ,Special education ,Educational anthropology ,media_common ,Case analysis - Published
- 2017
219. Current Concepts of Posterolateral Corner Injuries of the Knee
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Beum-Jung Kim, Oog-Jin Shon, and Jae Woo Park
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Posterolateral corner injuries ,030222 orthopedics ,medicine.medical_specialty ,business.industry ,Treatment outcome ,Biomechanics ,Instability ,Review Article ,030229 sport sciences ,Treatment ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Diagnosis ,Posterolateral corner ,Medicine ,Knee ,Orthopedics and Sports Medicine ,Surgery ,Sports activity ,business - Abstract
The number of posterolateral corner (PLC) injury patients has risen owing to the increased motor vehicle accidents and sports activities. Careful examination is required because this injury is easy to overlook and may lead to chronic instability. The purpose of this article is to review the anatomy, biomechanics, diagnosis, classification and, treatment of PLC injuries and summarize the recent literatures regarding the treatment outcomes.
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- 2017
220. Diagnostic Value of Technetium-99m Bone Scintigraphy in the Detection of Cervical Spine Metastases in Oncological Patients
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Bong Soon Chang, Hye Jin Yoo, Hui Jong Lee, Choon Ki Lee, Hyoungmin Kim, Ja Young Choi, Sang Min Park, and Jae Woo Park
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Radiography ,Technetium Tc 99m Medronate ,030218 nuclear medicine & medical imaging ,Metastasis ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Whole Body Imaging ,Orthopedics and Sports Medicine ,Medical diagnosis ,Child ,Radionuclide Imaging ,Aged ,Retrospective Studies ,Aged, 80 and over ,Spinal Neoplasms ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Bone scintigraphy ,Child, Preschool ,030220 oncology & carcinogenesis ,Cervical Vertebrae ,Female ,Neurology (clinical) ,Radiology ,business ,Technetium-99m ,Cohort study - Abstract
MINI: Bone scan remains the modality of choice for the screening of bone metastases. This study demonstrated the diagnostic value of bone scan in detecting bone metastases limited to the cervical spine in oncological patients remains uncertain due to the moderately high false-negative diagnostic rate.A retrospective cohort, radiographic study.To assess the diagnostic accuracy of bone scintigraphy (BS) for the detection of cervical spine metastases in oncological patients.BS remains the modality of choice for the screening of bone metastases, because of its feasibility in whole-body scanning and its widespread availability at low cost. Current practice guidelines for patients with malignant diseases recommend BS imaging as the primary screening method for detecting both axial and appendicular skeletal metastases.Of 481 patients, 242 were diagnosed with cervical spinal metastases from a primary cancer. The BS findings of these patients, evaluated by nuclear medicine physicians, were assessed with respect to their usefulness for detecting cervical spine metastases. Magnetic resonance imaging findings, evaluated by radiologists, were used as the reference standards. The diagnostic value of BS was compared between subgroups according to the order in which the diagnostic procedures (magnetic resonance imaging and BS) were completed, the presence of pathological fractures, the location of the primary malignancy, and the number of cervical metastases.The sensitivity of BS in the detection of cervical spine metastases was 59.1%, with a 40.9% rate of false-negative diagnoses; the specificity was 94.6%, with a 5.4% rate of false-positive diagnoses. The sensitivity tended to be higher in the presence of pathological fractures (72.1% in cases with a fracture vs. 3% in cases without a fracture) and a greater number of lesions (r = 0.921). Neither the order in which the diagnostic examinations were performed nor the location of the primary cancer, except for those in the stomach and liver, appeared to affect the diagnostic accuracy of BS.Considering the moderately high false-negative diagnostic rate obtained in the present study, BS alone cannot accurately diagnose metastases in the cervical spine in oncological patients.3.
- Published
- 2017
221. Hydrolytic degradation of polylactic acid (PLA) and its composites
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Moataz A. Elsawy, Jae-Woo Park, Akash Deep, and Ki-Hyun Kim
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chemistry.chemical_classification ,Materials science ,Renewable Energy, Sustainability and the Environment ,Plasticizer ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biodegradable polymer ,0104 chemical sciences ,Chitosan ,Polyester ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Polylactic acid ,Polymer chemistry ,Cellulose ,0210 nano-technology ,Glycolic acid - Abstract
Biodegradable polymers are seen as a potential solution to the environmental problems generated by plastic waste. In particular, the renewable aliphatic polyesters of poly(hydroxyacid)-type homopolymers and copolymers consisting of polylactic acid (PLA), poly(glycolic acid) (PGA), and poly(e-caprolactone) (PCL) constitute the most promising bioresorbable materials for applications in biomedical and consumer applications. Among those polymers, PLA has attracted particular attention as a substitute for conventional petroleum-based plastics. PLA is synthesized by the fermentation of renewable agricultural sources, including corn, cellulose, and other polysaccharides. Although some of its characteristics are disadvantageous (e.g., poor melt properties, mechanical brittleness, low heat resistance, and slow crystallization), there exist potential routes to resolve these shortcomings. These include copolymerization, blending, plasticization modification, or the addition of reinforcing phases (e.g., chitosan (Cs), cellulose, and starch). In this review, we discuss the degradation mechanisms of PLA and its modified form in the environment, current issues that hinder the achievement of good Cs/PLA combination, and ways to overcome some of these problems. Furthermore, our discussion is extended to cover the subjects of hydrolytic degradation and weathering effects with different Cs/PLA blends.
- Published
- 2017
222. Decontamination of radioactive cesium-contaminated soil/concrete with washing and washing supernatant– critical review
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Jung Hwan Kim, Yong Soo Kim, Jae-Woo Park, and Hassan Anwer
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Environmental Engineering ,Health, Toxicology and Mutagenesis ,0208 environmental biotechnology ,Inorganic chemistry ,Cesium ,02 engineering and technology ,010501 environmental sciences ,Vermiculite ,complex mixtures ,01 natural sciences ,Soil ,chemistry.chemical_compound ,Adsorption ,Soil Pollutants, Radioactive ,Environmental Chemistry ,Dissolution ,Decontamination ,0105 earth and related environmental sciences ,Ion exchange ,Nanotubes, Carbon ,Public Health, Environmental and Occupational Health ,Sorption ,Hydrogen Peroxide ,General Medicine ,General Chemistry ,Human decontamination ,Pollution ,020801 environmental engineering ,chemistry ,Cesium Radioisotopes ,Reagent ,Calcium silicate - Abstract
We reviewed washing of radioactive Cs-contaminated concrete and soil based on the fate of Cs in concrete and soil, including sorption materials for treatment of supernatant solution. In non-aged cement materials (the calcium silicate hydration (C-S-H) phase), it was possible to decontaminate Cs using ion exchange with monovalent cations, such as NH4+. The clay components in the soil and aggregates were important factors in optimization of the efficiency and mechanism for Cs decontamination with washing solution. The parameters (reagent component, pH, and temperature) of the washing solution should be determined considering soil mineral type (here, weathered biotite (WB) with vermiculite), since monovalent cations such as NH4+ and K+ can inhibit Cs decontamination due to collapse of the hydrated and expanded interlayer regions with cation exchange. In this case, hydrothermal treatment or H2O2 dosing was necessary to expand the collapsed interlayer region for Cs removal by washing with cation exchange or organic acids. Acid and a chelating agent significantly enhanced Cs-release with dissolution of the adsorbent layer containing iron and aluminum oxides. The important characteristics of important and emerging sorption materials for treatment of the radioactive Cs-contaminated supernatant after washing treatment are discussed. Sorbents for treatment of washing supernatant are divided in to two main categories. Clay minerals, metal hexacyanoferrates, and ammonium molybdophosphates are discussed in the inorganic class of materials. Hypercrosslinked polymers, supramolecular sorbents, carbon nanotubes, and graphene oxide are covered in the carbon-based sorbents for Cs removal from water.
- Published
- 2021
223. Gwakhyangjeonggi-san for irritable bowel syndrome
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Gajin Han, Keum-ji Kim, Jong-Won Park, Hyejin Jun, Jae-Woo Park, and Seok-Jae Ko
- Subjects
Abdominal pain ,medicine.medical_specialty ,MEDLINE ,law.invention ,Bloating ,systematic review ,Randomized controlled trial ,Quality of life ,law ,Study Protocol Systematic Review ,medicine ,Humans ,Intensive care medicine ,Irritable bowel syndrome ,Data Management ,irritable bowel syndrome ,business.industry ,Standard treatment ,Gwakhyangjeonggi-san ,General Medicine ,medicine.disease ,Meta-analysis ,randomized controlled trial ,Quality of Life ,medicine.symptom ,business ,Drugs, Chinese Herbal ,Research Article - Abstract
Background: Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by abdominal pain or discomfort, stool irregularities, and bloating. Owing to its atypical symptoms and various mechanisms, there is no standard treatment for IBS. Gwakhyangjeonggi-san (GJS), a traditional Korean herbal medicine, has been used to treat lower intestinal abnormalities in Asia. We will systematically review randomized controlled trials (RCTs) to evaluate the efficacy and safety of GJS as a complementary treatment for IBS. Methods and analysis: Four English databases, namely, Medline (via PubMed), EMBASE, the Cochrane Central Register of Controlled Trials, and the Allied and Complementary Medicine Database, will be searched for entries up to May, 2021. Additional databases will include 5 Korean databases, 1 Chinese database, and 1 Japanese database. RCTs and quasi-RCTs will be searched for to assess the effectiveness and safety of GJS. The primary outcome measure will be the overall efficacy rate, and the secondary outcome will include data such as global symptom scores, IBS Quality of Life measurements, and adverse events. Data analysis will be performed using Review Manager Version 5.3, and the risk of bias will be assessed using the Cochrane Collaboration's risk-of-bias tool. The quality of the results will be evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach. Conclusion: This systematic review will provide evidence for the efficacy and safety of GJS for IBS. OSF registration number: DOI 10.17605/OSF.IO/V93JN (https://osf.io/v93jn).
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- 2021
224. Herbal medicine for irritable bowel syndrome
- Author
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Seok-Jae Ko, Jinsung Kim, Hyejin Jun, Keum-ji Kim, Jae-Woo Park, and Hwan-Su Jung
- Subjects
Protocol (science) ,medicine.medical_specialty ,Abdominal pain ,Bowel habit ,business.industry ,MEDLINE ,General Medicine ,medicine.disease ,Placebo ,03 medical and health sciences ,0302 clinical medicine ,Systematic review ,030220 oncology & carcinogenesis ,medicine ,030212 general & internal medicine ,medicine.symptom ,Intensive care medicine ,Complementary medicine ,business ,Irritable bowel syndrome - Abstract
Background Irritable bowel syndrome (IBS) is a common disorder characterized by the recurrence of abdominal pain and changes in bowel habits. Owing to the limitations of conventional treatments, patients with IBS are often dissatisfied with the effect of treatment and have a poor quality of life. Herbal medicines (HMs) are frequently used for the treatment of IBS. This protocol was designed through an overview of systematic reviews (SRs), to investigate the safety and efficacy of HMs for treating IBS. Methods SRs published up to May 2021 will be searched from the following 6 electronic databases: Medline (via PubMed), EMBASE, Cochrane Database of Systematic Reviews, Allied and Complementary Medicine Database, Oriental Medicine Advanced Searching Integrated System, and China National Knowledge Infrastructure database. SRs and/or meta-analyses on the use of HMs for IBS will be included in this overview. The effects of a placebo, no treatment, usual care, or conventional treatment will be compared with those of HMs. Two investigators will independently extract the data and assess the methodological and evidence quality for each main finding. The total clinical effectiveness rate will be measured as the primary outcome. Results This overview is expected to provide data on the use of HMs for the treatment of IBS based on qualitative and quantitative syntheses of the included SR data. Conclusion This overview will evaluate and propose the efficacy and safety of HMs for the treatment of IBS. Registration number DOI 10.17605/OSF.IO/NT6WZ (https://osf.io/nt6wz).
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- 2021
225. Accessory Talar Facet Impingement and Sinus Tarsi Pain Associated With Accessory Anterolateral Talar Facet
- Author
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Jae Woo Park, Chul Hyun Park, and JeongJin Park
- Subjects
Facet (geometry) ,business.industry ,Pain ,Tarsal Coalition ,Anatomy ,Talus ,medicine.anatomical_structure ,Case-Control Studies ,medicine ,Humans ,Heel ,Orthopedics and Sports Medicine ,Surgery ,Sinus Tarsus ,Ankle ,business - Abstract
Background: Sinus tarsi pain caused by accessory talar facet impingement (ATFI) owing to accessory anterolateral talar facet (AALTF) is not well documented. We evaluated prevalence of AALTF and differences of magnetic resonance imaging (MRI) findings between persons with and without sinus tarsi pain, and investigated the relevant association between MRI findings and sinus tarsi pain in persons with AALTF. Methods: We performed a case-control study on 120 ankles with sinus tarsi pain and 120 age- and gender-matched ankles without sinus tarsi pain. As MRI findings, bone marrow edema (BME), sinus tarsi fat obliteration (STFO), calcaneal cyst, talocalcaneal coalition, Gissane angle, talar inferolateral surface (TILS) angle, and calcaneal cortical thickness (CCT) were evaluated. The MRI findings were compared between persons with and without sinus tarsi pain, and between persons with and without AALTF. Among persons with AALTF, MRI findings were compared between those with and without sinus tarsi pain. Relevant association was evaluated between MRI findings and sinus tarsi pain in persons with AALTF. Results: Presence of AALTF, BME, and STFO were significantly higher in the group with sinus tarsi pain. The Gissane angle was significantly smaller, and the TILS angle and CCT were significantly larger in the group with sinus tarsi pain. The BME (OR 7.571, CI 1.453-39.446) and small Gissane angle (OR 0.891, CI 0.804-0.986) were significantly associated with sinus tarsi pain in persons with the AALTF. Conclusion: The study provides evidence for ATFI related to impingement of an AALTF associated with talocalcaneal BME. Level of Evidence: Level III, case-control study.
- Published
- 2021
226. Clinical Case Report of PPI-refractory Gastro-Esophageal Reflux Disease (GERD) with Korean Medicine Treatment - A Focus on Evaluation of the Abdominal Examination
- Author
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Jae-hong Lee, Seok-Jae Ko, Soo-ho Cho, and Jae-Woo Park
- Subjects
medicine.medical_specialty ,business.industry ,General surgery ,Traditional Korean medicine ,Gastro-esophageal reflux disease ,medicine.disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,030220 oncology & carcinogenesis ,Internal medicine ,Abdominal examination ,medicine ,GERD ,030211 gastroenterology & hepatology ,Clinical case ,business - Published
- 2017
227. An estimation framework for building information modeling (BIM)-based demolition waste by type
- Author
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Jae Woo Park, Won-Hwa Hong, Young-Chan Kim, and Gi-Wook Cha
- Subjects
Estimation ,Engineering ,Matching (statistics) ,Environmental Engineering ,Construction Materials ,business.industry ,0211 other engineering and technologies ,Volume (computing) ,Industrial Waste ,02 engineering and technology ,Plan (drawing) ,Models, Theoretical ,010501 environmental sciences ,Building design ,01 natural sciences ,Pollution ,Construction engineering ,Waste Management ,Building information modeling ,Demolition waste ,021105 building & construction ,Demolition ,business ,0105 earth and related environmental sciences - Abstract
Most existing studies on demolition waste (DW) quantification do not have an official standard to estimate the amount and type of DW. Therefore, there are limitations in the existing literature for estimating DW with a consistent classification system. Building information modeling (BIM) is a technology that can generate and manage all the information required during the life cycle of a building, from design to demolition. Nevertheless, there has been a lack of research regarding its application to the demolition stage of a building. For an effective waste management plan, the estimation of the type and volume of DW should begin from the building design stage. However, the lack of tools hinders an early estimation. This study proposes a BIM-based framework that estimates DW in the early design stages, to achieve an effective and streamlined planning, processing, and management. Specifically, the input of construction materials in the Korean construction classification system and those in the BIM library were matched. Based on this matching integration, the estimates of DW by type were calculated by applying the weight/unit volume factors and the rates of DW volume change. To verify the framework, its operation was demonstrated by means of an actual BIM modeling and by comparing its results with those available in the literature. This study is expected to contribute not only to the estimation of DW at the building level, but also to the automated estimation of DW at the district level.
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- 2017
228. Count of platelet and mean platelet volume score: serologic prognostic factor in patients with oral squamous cell carcinoma
- Author
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Moon Young Kim, Yong Chan Ha, Jae Woo Park, Chul-Hwan Kim, and Sung-Min Park
- Subjects
Pathology ,medicine.medical_specialty ,Mean platelet volume ,030204 cardiovascular system & hematology ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,White blood cell ,Internal medicine ,Count of platelet ,Medicine ,Stage (cooking) ,Pathological ,Univariate analysis ,Prognostic factor ,Proportional hazards model ,business.industry ,Hazard ratio ,medicine.anatomical_structure ,Oral squamous cell carcinoma ,030220 oncology & carcinogenesis ,Oral and maxillofacial surgery ,Surgery ,Original Article ,Oral Surgery ,business - Abstract
Objectives TNM staging, especially for lymph node metastasis, is the scoring system most widely used among prognostic factors for cancer survival. Several biomarkers have been studied as serologic markers, but their specificity is low and clinical applications are difficult. This study aimed to establish a scoring system for patients with oral squamous cell carcinoma (OSCC) using platelet (PLT) and mean platelet volume (MPV) levels measured postoperatively and to evaluate their significance as prognostic factors. Materials and Methods We studied 40 patients admitted to the Department of Oral and Maxillofacial Surgery of Dankook University Hospital who were diagnosed with primary OSCC histopathologically between May 2006 and May 2012. Clinical pathological information obtained from the medical records of each patient included age, sex, height, weight, tumor location, degree of differentiation, tumor diameter, lymph node metastasis, TNM stage, and other test values including white blood cell, MPV, PLT, C-reactive protein (CRP), and albumin obtained through a test conducted within 7 days before surgery. Count of platelet (COP)-MPV Score: Patients with both PLT and MPV values below the cut-off values were defined as score 0 (group A). Patients with at least one of the two higher than the cut-off value were defined as score 1 (group B). Results Univariate analyses showed N-metastasis, COP-MPV (A vs B), PLT, platelet-lymphocyte ratio, and CRP were statistically significant prognostic factors. A multivariate Cox proportional hazards model showed N-metastasis (hazard ratio [HR] 6.227, P=0.016) and COP-MPV (A vs B) (HR 18.992, P=0.013) were independent prognostic factors with a significant effect on survival. Conclusion COP-MPV score is a simple and cost-effective test method and is considered a more effective prognostic factor than other considered factors in predicting the prognosis of OSCC patients.
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- 2017
229. Correlation between Dysgeusia and Spleen qi Deficiency Patterns in Patients with Burning Mouth Syndrome
- Author
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Jae-Woo Park, Jinsung Kim, and Jung-eun Lee
- Subjects
medicine.medical_specialty ,business.industry ,Dentistry ,Spleen ,030206 dentistry ,Burning mouth syndrome ,Dermatology ,030205 complementary & alternative medicine ,Dysgeusia ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Taste disorder ,medicine ,In patient ,Taste Threshold ,medicine.symptom ,business - Published
- 2017
230. Analysis of Existing Guidelines and Randomized, Controlled, Clinical Trials for Development of [Guideline of Clinical Trial with Herbal Medicinal Product for gastric cancer]
- Author
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Gajin Han, Sin Seong, Sungsu Kim, Jinsung Kim, and Jae-Woo Park
- Subjects
03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology - Published
- 2017
231. Nitrogen Budget of South Korea Including Gaseous Nitrogen Oxides from 2012 to 2014
- Author
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Jae-Woo Park, Seyeon Oa, and Hanuk Lee
- Subjects
chemistry ,Waste management ,chemistry.chemical_element ,Environmental science ,Gaseous nitrogen ,Nitrogen - Published
- 2017
232. The novel resveratrol derivative 3,5-diethoxy-3′,4′-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro
- Author
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Jae Woo Park, Sung-hoon Back, Hyoungsu Kim, Phil-jun Lee, Hong-pyo Kim, Woogyun Choi, Sungchan Cho, Byung-Sam Kim, Hun-Taeg Chung, Su-wol Chung, Jong-heon Kim, and Byoung Heon Kang
- Subjects
0301 basic medicine ,Mitochondrial ROS ,Programmed cell death ,Carcinoma, Hepatocellular ,Time Factors ,Cell ,Apoptosis ,Biology ,Resveratrol ,Mitochondrion ,Inhibitory Concentration 50 ,03 medical and health sciences ,chemistry.chemical_compound ,Stilbenes ,medicine ,Humans ,Pharmacology (medical) ,Membrane Potential, Mitochondrial ,Pharmacology ,Dose-Response Relationship, Drug ,Liver Neoplasms ,food and beverages ,Hep G2 Cells ,General Medicine ,Endoplasmic Reticulum Stress ,Antineoplastic Agents, Phytogenic ,In vitro ,Mitochondria ,Cell biology ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,Biochemistry ,chemistry ,Unfolded protein response ,Original Article ,Reactive Oxygen Species - Abstract
Resveratrol (3,5,4′-trihydroxy- trans -stilbene) is a well-known polyphenol that is present in grapes, peanuts, pine seeds, and several other plants. Resveratrol exerts deleterious effects on various types of human cancer cells. Here, we analyzed the cell death-inducing mechanisms of resveratrol-006 (Res-006), a novel resveratrol derivative in human liver cancer cells in vitro . Res-006 suppressed the viability of HepG2 human hepatoma cells more effectively than resveratrol (the IC 50 values were 67.2 and 354.8 μmol/L, respectively). Co-treatment with the ER stress regulator 4-phenylbutyrate (0.5 mmol/L) or the ROS inhibitor N -acetyl- L -cysteine (NAC, 1 mmol/L) significantly attenuated Res-006-induced HepG2 cell death, suggesting that pro-apoptotic ER stress and/or ROS may govern the Res- 006-induced HepG2 cell death. We further revealed that treatment of HepG2 cells with Res-006 (65 μmol/L) immediately elicited the dysregulation of mitochondrial dynamics and the accumulation of mitochondrial ROS. It also collapsed the mitochondrial membrane potential and further induced ER stress and cell death. These events, except for the change in mitochondrial morphology, were prevented by the exposure of the HepG2 cells to the mitochondrial ROS scavenger, Mito-TEMPO (300–1000 μmol/L). The results suggest that Res-006 may kill HepG2 cells through cell death pathways, including the ER stress initiated by mitochondrial ROS accumulation. The cell death induced by this novel resveratrol derivative involves crosstalk between the mitochondria and ER stress mechanisms.
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- 2017
233. Synthesis of thienopyrimidine-pyrazolo[3,4-b]pyridine hybrids
- Author
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Jae Woo Park and Yang-Heon Song
- Subjects
chemistry.chemical_compound ,chemistry ,010405 organic chemistry ,Organic Chemistry ,Pyridine ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Iron(III) chloride ,0104 chemical sciences ,Hybrid - Abstract
New hybrid compounds, thienopyrimidinyl-1H-pyrazolo[3,4-b]pyridine derivatives, were efficiently synthesized by the three-component reaction of 3-phenyl-1-(thienopyrimidin-4-yl)-1H-pyrazol-5-amine, benzoylacetonitrile and an aromatic aldehyde in the presence of FeCl3 on basic alumina.
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- 2017
234. Does Lordotic Angle of Cage Determine Lumbar Lordosis in Lumbar Interbody Fusion?
- Author
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Nak-Chul Kim, Kyu Jung Cho, Jae-Woo Park, Taek-Ho Hong, Beom-Ho Seo, and Young Tae Kim
- Subjects
Male ,medicine.medical_specialty ,Lordosis ,Radiography ,Bony union ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Lumbar interbody fusion ,medicine ,Humans ,Orthopedics and Sports Medicine ,Aged ,Retrospective Studies ,030222 orthopedics ,Lumbar Vertebrae ,business.industry ,Background data ,Middle Aged ,medicine.disease ,Surgery ,Spinal Fusion ,Female ,Neurology (clinical) ,Cage ,Lumbar lordosis ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
STUDY DESIGN Retrospective, radiological analysis. OBJECTIVE To determine that 15° lordotic angle cages create higher lumbar lordosis in open transforaminal lumbar interbody fusion (TLIF) than 4° and 8° cages. SUMMARY OF BACKGROUND DATA Restoration of lumbar lordosis is important to obtain good outcome after lumbar fusion surgery. Various shapes and angles of cages in interbody fusion have been used; however, it is not proved that lordotic angle of cages determine lumbar lordosis. METHODS Sixty-seven patients were evaluated after TLIF using 15° cages and screw instrumentation. For comparison, TLIF using 4° lordotic angle cages in 65 patients and 8° cages in 49 patients were analyzed. Lumbar lordosis angles, segmental lordosis angles, disc height, and bony union rate were measured on the radiographs. RESULTS The lumbar lordosis was 31.1° preoperatively, improved to 42.9° postoperatively, and decreased to 36.4° at the last follow-up in the 15° group. It was 35.8° before surgery, corrected to 41.5° after surgery, and changed to 33.6° at the last follow-up in the 4° group. In the 8° group, it was 32.7° preoperatively, improved to 39.1° postoperatively, and decreased to 34.5° at the last follow-up. These changes showed statistical significances (P
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- 2017
235. Graphene and its nanocomposites as a platform for environmental applications
- Author
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Jongki Hong, Vanish Kumar, Sandeep Kumar, Ki-Hyun Kim, and Jae-Woo Park
- Subjects
Nanocomposite ,Graphene ,Chemistry ,General Chemical Engineering ,Functionalized graphene ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Reuse ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,law.invention ,Nanomaterials ,law ,Photocatalysis ,Environmental Chemistry ,0210 nano-technology ,Photocatalytic degradation ,Science, technology and society - Abstract
Graphene is a two-dimensional nanomaterial with unique characteristics that can be used to efficiently remove organic pollutants in the aqueous system via adsorption and photocatalytic degradation. This review was organized to offer valuable insights into the mechanisms regulating the graphene and its related nanomaterials as the platform for the treatment of various organic pollutants in aqueous media. To this end, the performance variables of graphene, functionalized graphene, and graphene-supported materials are evaluated for such applications in some respects. Our discussion is extended further to describe regeneration and reuse of these nanomaterials along with future challenges encountered in their applications, especially on toxicity and stability aspects.
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- 2017
236. Epimedii Herba: A Promising Herbal Medicine for Neuroplasticity
- Author
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Youngmin Bu, Jae-Woo Park, Kyungjin Lee, Jae-Heung Cho, Beom-Joon Lee, and Jae-Young Jung
- Subjects
0301 basic medicine ,Pharmacology ,Epimedium ,Traditional medicine ,biology ,business.industry ,Spontaneous reaction ,MEDLINE ,Brain recovery ,Functional recovery ,medicine.disease ,biology.organism_classification ,Bioinformatics ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neuroplasticity ,Yang deficiency ,Medicine ,Dementia ,business ,030217 neurology & neurosurgery - Abstract
Epimedii Herba (EH) is an herbal medicine originating from several plants of the genus Epimedium. It is a major therapeutic option for kidney yang deficiency syndrome, which is closely related to androgen hormones and also has been used to treat hemiplegia following a stroke in traditional medicine of Korea and PR China. To date, many clinical and basic researches of EH have shown the activities on functional recovery from brain diseases. Recently, neuroplasticity, which is the spontaneous reaction of the brain in response to diseases, has been shown to accelerate functional recovery. In addition, androgen hormones including testosterone are known to be the representative of neuroplasticity factors in the brain recovery processes. In this review, we described the neuro-pharmacological activities of EH, focusing on neuroplasticity. Thirty-three kinds of papers from MEDLINE/PubMed, EMBASE, and CNKI were identified and analyzed. We categorized the results into five types based on neuroplasticity mechanisms and presented the definition of each category and briefly described the results of these papers. Altogether, we can suggest that neuroplasticity is a novel viewpoint for guiding future brain research of EH and provide the evidence for the development of new clinical applications using EH in the treatment of brain diseases. Copyright © 2017 John Wiley & Sons, Ltd.
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- 2017
237. PDMS microchannel surface modification with teflon for algal lipid research
- Author
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Jae Woo Park, Myeongwoo Kang, Sang Jun Sim, Sangcheol Na, and Noo Li Jeon
- Subjects
Microchannel ,Materials science ,Polydimethylsiloxane ,010401 analytical chemistry ,Microfluidics ,technology, industry, and agriculture ,Biomedical Engineering ,Nile red ,Bioengineering ,Nanotechnology ,macromolecular substances ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,Contact angle ,chemistry.chemical_compound ,chemistry ,Surface modification ,Electrical and Electronic Engineering ,BODIPY ,0210 nano-technology ,Biotechnology - Abstract
This paper presents a simple method for modifying the polydimethylsiloxane (PDMS) microfluidic channels with Teflon for algal lipid research. When culturing and staining algae inside microfluidic devices, the small molecule dyes absorbed by the microchannel surface render it difficult for imaging and quantification. PDMS surface coated with Teflon-AF resists the absorption of hydrophobic dye molecules (i.e., BODIPY and Nile red) as confirmed using fluorescence microscopy. Here, we introduce a surface modification of PDMS microchannel using Teflon-AF using a procedure of filling and drying to directly treat the PDMS surface with perfluorinated materials. This method can be used to prevent the absorption of fluorescent probe and obtain clear fluorescence micrographs without background signal from absorbed dye molecules on PDMS microchannel. We confirmed that contact angle of Teflon-coated PDMS (116.4°) is higher than that of unmodified PDMS (106.1°) and thus more hydrophobic. Furthermore, Teflon-coated PDMS surface had ~80% of oxygen transfer rate compared to that of native PDMS and good transparency in all visible light regions. Based on these characteristics, we successfully validated the visualization and quantification of intracellular lipid droplets in microalgae C. reinhardtii using BODIPY. We believe that our new method will expand microfluidic applications on characterization of biological lipid with fluorescence probes and biochemical markers.
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- 2017
238. A Sternum-Disk Distance Method to Identify the Skin Level for Approaching a Surgical Segment without Fluoroscopy Guidance during Anterior Cervical Discectomy And Fusion
- Author
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Jin S. Yeom, Ji Hoon Shin, Ji Hoon Lee, Bo Gun Suh, Myun Whan Ahn, Gun Woo Lee, Jae Woo Park, Dong Wook Kim, Jae Hyung Uh, and Jong Ho Park
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Cervical vertebrae ,medicine.medical_treatment ,lcsh:Medicine ,Fleiss' kappa ,Anterior cervical discectomy and fusion ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Magnetic resonance imaging ,0302 clinical medicine ,Cohen's kappa ,Sternum-disk distance method ,medicine ,Fluoroscopy ,Orthopedics and Sports Medicine ,medicine.diagnostic_test ,business.industry ,lcsh:R ,medicine.anatomical_structure ,Spinal fusion ,Orthopedic surgery ,Clinical Study ,Surgery ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
Study DesignA retrospective review of prospectively collected data.PurposeTo introduce the sternum-disk distance (SDD) method for approaching the exact surgical level without C-arm guidance during anterior cervical discectomy and fusion (ACDF) surgery and to evaluate its accuracy and reliability.Overview of LiteratureAlthough spine surgeons have tried to optimize methods for identifying the skin level for accessing the operative disk level without C-arm guidance during ACDF, success has rarely been reported.MethodsIn total, 103 patients who underwent single-level ACDF surgery with the SDD method were enrolled. The primary outcome measure was the accuracy of the SDD method. The secondary outcome measures were the mean SDD value at each cervical level from the cranial margin of the sternum in the neutral and extension positions of the cervical spine and the inter- and intra-observer reliability of the SDD outcome determined using repeated measurements by three orthopedic spine surgeons.ResultsThe SDD accuracy (primary outcome measure) was indicated in 99% of the patients (102/103). The mean SDD values in the neutral-position magnetic resonance imaging (MRI) were 108.8 mm at C3–C4, 85.3 mm at C4–C5, 64.4 mm at C5–C6, 44.3 mm at C6–C7, and 24.1 mm at C7–T1; and those in the extension-position MRI were 112.9 mm at C3–C4, 88.7 mm at C4–C5, 67.3 mm at C5–C6, 46.5 mm at C6–C7, and 24.3 mm at C7–T1. The Cohen kappa coefficient value for intra-observer reliability was 0.88 (excellent reliability), and the Fleiss kappa coefficient value for inter-observer reliability as reported by three surgeons was 0.89 (excellent reliability).ConclusionsBased on the results of the present study, we recommend performing ACDF surgery using the SDD method to determine the skin level for approaching the surgical cervical segment without fluoroscopic guidance.
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- 2017
239. Generation of 3D Terrain Map using Cell Deviation Algorithm for Earthwork
- Author
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Soon-Wook Kwon, Seok Kim, Du-Heon Lee, and Jae-Woo Park
- Subjects
Construction management ,Engineering ,business.industry ,Component (UML) ,3d terrain ,Earthworks ,General Medicine ,Plan (drawing) ,business ,Automation ,Civil engineering ,Fleet management ,Machine control - Abstract
This study aims to automate earthworks by digitizing earthwork sites through a three-dimensional (3D) geotechnical analysis platform. Institutionalization is required to promote the development of related component technologies and applications of the technologies suitable to the characteristics of construction projects in South Korea. The 3D geotechnical analysis platform has already been developed and completed demonstration tests. Through the tests, it is verified that the database derived from the platform contains coordinates of topography, soil quality, drilling, earthwork quantity, cutting or filling information, which is the basic information of earthwork planning used in fleet management. Furthermore, the study aims to understand the current systems, standards and manuals on earthwork automation in the US and Japan to establish measures to institutionalize and promote the earthwork automation for South Korea. Additional research will be performed to define the cell types in consideration of various ground shapes to plan movement directions and stop locations of the equipment.
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- 2017
240. Coherent intermolecular proton transfer in the acid–base reaction of excited state pyranine
- Author
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Nizam Uddin, Young Min Rhee, Jae Woo Park, Taiha Joo, Cheol Ho Choi, and Wooseok Heo
- Subjects
education.field_of_study ,010304 chemical physics ,Proton ,Hydrogen bond ,Intermolecular force ,Population ,General Physics and Astronomy ,010402 general chemistry ,Photochemistry ,01 natural sciences ,0104 chemical sciences ,Pyranine ,Photoexcitation ,chemistry.chemical_compound ,chemistry ,Excited state ,Molecular vibration ,0103 physical sciences ,Physical and Theoretical Chemistry ,education - Abstract
Detailed molecular dynamics simulations of an acid-base reaction have been the subject of extensive investigations. Here we report the excited state proton transfer dynamics of pyranine (8-hydroxypyrene-1,3,6-trisulfonic acid, HPTS) in acetate buffer by time-resolved fluorescence (TF) and quantum mechanical/effective fragment potential molecular dynamics (QM/EFP-MD) simulations. High time resolution in TF and TF spectra measurements allows the acquisition of accurate reaction kinetics. Upon the photoexcitation of HPTS, the proton (deuterium) is transferred coherently to acetate in 60 fs (80 fs) for a contact pair of HPTS (DPTS) and acetate by a hydrogen bond, which comprises approximately 28% of the population. ESPT proceeds slowly on a picosecond time scale for the remaining HPTS as reported previously. Coherent wave packet motions of the reactant (acid) and the product (conjugate base) enable the acquisition of the vibrational spectra of excited states via TF (VETF). A comparison of the VETFs of the reactant and the product and the calculation of the Huang-Rhys factors (vibrational reorganization energies) identify the vibrational modes that actively participate in the coherent proton transfer. In particular, the 246 cm-1 vibrational mode, which consists of in-plane skeletal stretching motion, promotes the ESPT by transferring the donor oxygen towards the acceptor oxygen in acetate. QM/EFP MD simulations corroborate the experiment and provide molecular details of the ESPT.
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- 2017
241. Geraniin Promotes Recovery of Hematopoietic Cells after Radiation Injury
- Author
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Jinhee Cho, Areum Kim, Ginnae Ahn, So Jin Bing, Kalahe Hewage Iresha Nadeeka Madushani Herath, Youngheun Jee, Jae Woo Park, and Nam Ho Lee
- Subjects
0301 basic medicine ,Cell ,Geraniin ,Bone Marrow Cells ,Radiation-Protective Agents ,Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Immune system ,Glucosides ,Nymphaea ,medicine ,Splenocyte ,Animals ,Mitosis ,Cells, Cultured ,Cell Proliferation ,Cell Differentiation ,General Medicine ,Hematopoietic Stem Cells ,Hydrolyzable Tannins ,Cell biology ,Mice, Inbred C57BL ,Radiation Injuries, Experimental ,Haematopoiesis ,030104 developmental biology ,medicine.anatomical_structure ,Complementary and alternative medicine ,chemistry ,Gamma Rays ,030220 oncology & carcinogenesis ,Immunology ,Bone marrow ,Stem cell ,Injections, Intraperitoneal ,Spleen ,Phytotherapy - Abstract
Cells of the hematopoietic system are uniquely radiosensitive due to their rapid proliferation. Consequently, immune suppression readily and undesirably results from irradiation. Our previous studies demonstrated that geraniin isolated from Nymphaea tetragona var. angusta (water lily) had a protective effect on the splenocytes and intestinal tract of irradiated mice. This study was designed to assess the effectiveness of geraniin, an ellagitannin isolated from the water lily, in decreasing gamma ray irradiation-induced destruction of the hematopoietic system in mice. Geraniin treatment improved the survival time of bone marrow cells and maintained bone marrow integrity and also up-regulated the expression of stem cell receptors and the extent of cell mitosis. Geraniin also enhanced the proliferation and differentiation of immune cells that had been suppressed by irradiation. These results suggest geraniin is a promising agent for reconstituting hematopoietic cells after exposure to irradiation.
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- 2017
242. Smart Merging Method for Hybrid Point Cloud Data using UAV and LIDAR in Earthwork Construction
- Author
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Soon-Wook Kwon, Hee-Sung Park, Daeyoon Moon, Jae-Woo Park, and Suwan Jung
- Subjects
Engineering ,Laser scanning ,business.industry ,Real-time computing ,0211 other engineering and technologies ,Point cloud ,Usability ,02 engineering and technology ,General Medicine ,3D modeling ,Automation ,Photogrammetry ,Lidar ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Computer vision ,Artificial intelligence ,business ,Spatial analysis ,021101 geological & geomatics engineering - Abstract
In recent years, much progress has been made in the construction sector through the use of automation and information technology. Due to an increasing demand for 3D modeling of spatial information, a variety of techniques have been developed. In addition, point cloud data generation technology using laser scanners and PhotoScan is attracting attention as a means of creating 3D model data on construction sites. In this paper, 3D point cloud data to be used in earthwork projects is generated using a hybrid scanning method (a laser scanner and UAV aerial photograph data are used in combination), while verifying the usability of the 3D point cloud data by merging the generated data. The objective of this study is to present a hybrid scanning method for the 3D modeling of earthwork in construction operations. Utilizing the hybrid scanning method proposed in this paper, it is possible to quickly and accurately process 3D mapping of atypical ground shapes that continually change according to the construction situation. This study is expected to be used as fundamental research in the Intelligent Task Planning System, which can extract the amount of progress in earthwork projects.
- Published
- 2017
243. Accuracy of one-step automated orthodontic diagnosis model using a convolutional neural network and lateral cephalogram images with different qualities obtained from nationwide multi-hospitals.
- Author
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Sunjin Yim, Sungchul Kim, Inhwan Kim, Jae-Woo Park, Jin-Hyoung Cho, Mihee Hong, Kyung-Hwa Kang, Minji Kim, Su-Jung Kim, Yoon-Ji Kim, Young Ho Kim, Sung-Hoon Lim, Sang Jin Sung, Namkug Kim, and Seung-Hak Baek
- Subjects
ORTHODONTIC diagnosis ,ARTIFICIAL neural networks ,ORTHODONTICS ,DENTISTRY ,RECEIVER operating characteristic curves - Published
- 2022
- Full Text
- View/download PDF
244. Recent results on Choi's orthogonal Latin squares.
- Author
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Jon-Lark Kim, Dong Eun Ohk, Doo Young Park, and Jae Woo Park
- Subjects
MAGIC squares ,KRONECKER products ,LEAST squares - Abstract
Choi Seok-Jeong studied Latin squares at least 60 years earlier than Euler although this was less known. He introduced a pair of orthogonal Latin squares of order 9 in his book. Interestingly, his two orthogonal non-double-diagonal Latin squares produce a magic square of order 9, whose theoretical reason was not studied. There have been a few studies on Choi's Latin squares of order 9. The most recent one is Ko-Wei Lih's construction of Choi's Latin squares of order 9 based on the two 3 3 orthogonal Latin squares. In this paper, we give a new generalization of Choi's orthogonal Latin squares of order 9 to orthogonal Latin squares of size n2 using the Kronecker product including Lih's construction. We find a geometric description of Choi's orthogonal Latin squares of order 9 using the dihedral group D8. We also give a new way to construct magic squares from two orthogonal non-double-diagonal Latin squares, which explains why Choi's Latin squares produce a magic square of order 9. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
245. Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model.
- Author
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Hong-Geol Kim, Seok-Jae Ko, Burmgi Hong, Jinsung Kim, Beomjoon Lee, Hyejin Joo, Hye Hyun Yoo, In Sook Kim, Hwan-Su Jung, Won Kyu Chang, Hyun-Chul Kim, Youngmin Bu, and Jae-Woo Park
- Abstract
Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified BGT, was developed by mixing the extracts of Lonicera japonica Thunb., Alisma orientalis and Atractylodes macrocephala based on a literature review and screening of 16 kinds of component herbs of BGT. A colitis mouse (Male, BALB/c) model was induced using dextran sulfate sodium (5%). The effects of BGT and mBGT on body weight, histological damage, clinical score, macroscopic score and colon length were compared. The mechanisms of action were analyzed based on cytokine production in colon tissue. mBGT at 300mg/kg showed similar effectiveness to that of BGT on colon shortening (P<0.01), clinical score (P<0.05), macroscopic score (P<0.01) and histological damage (P<0.01). In addition, mBGT decreased cytokines, including Interleukin 1 beta, tumor necrosis factor alpha and Interleukin 17, in a dose-dependent manner. In conclusion, mBGT could be a substitute prescription for BGT in clinics and a candidate for the development of a new BGT-based therapeutic agent against colitis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
246. Distribution of90Sr Activities in the Environmental Radiation Samples of Jeju Island, Korea
- Author
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Young Gyu Lee, Jae Woo Park, Youn Hyun Park, and Chung Hun Han
- Subjects
Radiation ,Distribution (number theory) ,Health, Toxicology and Mutagenesis ,Liquid scintillation counting ,Public Health, Environmental and Occupational Health ,Mineralogy ,Radiology, Nuclear Medicine and imaging ,Geology - Published
- 2016
247. Characteristics of Medical Advertisement according to the Various Departments at Medical Institutions
- Author
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Dong-Woo Lee, Byung-Deog Hwang, and Jae-Woo Park
- Subjects
Advertising ,Business - Published
- 2016
248. Effects of Workplace Drinking Environment and Individual’s Intention on Problem Drinking among Female Hospital Worker
- Author
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Byung-Deog Hwang and Jae-Woo Park
- Subjects
business.industry ,Environmental health ,Medicine ,Drinking environment ,business - Published
- 2016
249. Effect of generation growth on photocatalytic activity of nano TiO 2 -magnetic cored dendrimers
- Author
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Jong-Jin Jung, Jae-Woo Park, and Jun-Won Jang
- Subjects
Materials science ,Scanning electron microscope ,General Chemical Engineering ,Energy-dispersive X-ray spectroscopy ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Dendrimer ,Titanium dioxide ,Nano ,Methyl orange ,Photocatalysis ,0210 nano-technology - Abstract
Titanium dioxide (TiO2) nanoparticles were individually grafted on magnetic-cored dendrimers of 0th, 1st, 2nd, and 3rd generations. Dendrimer’s fractal structure makes nano TiO2 functional group disperse well in water, so we can make full use of the surface area of each nanoparticle to improve photocatalysis. Furthermore, nano TiO2 functionalized magnetite-cored dendrimer (nano TiO2-MD) can be easily recycled by an external magnetic field. Synthesized nano TiO2-MDs of various generations were confirmed with scanning electron microscopy, energy dispersive spectroscopy analysis, X-ray diffraction, and Fourier transform-infrared spectroscopy. Pseudo first order reaction rate constants of methyl orange increased with the generation number of nano TiO2-MDs, but photocatalytic activity after five cycles of reuse was inversely proportional to the generation number. Generation growth directly increases the number of nano TiO2 functional groups to enhance the photocatalytic activity, but more loss of photocatalytic activity was observed in repeated use of higher generations of nano TiO2-MDs.
- Published
- 2016
250. Carboxymethyl chitosan-modified magnetic-cored dendrimer as an amphoteric adsorbent
- Author
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Hye-Ran Kim, Jae-Woo Park, and Jun-Won Jang
- Subjects
Environmental Engineering ,Chemistry ,Health, Toxicology and Mutagenesis ,Inorganic chemistry ,Cationic polymerization ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Pollution ,0104 chemical sciences ,Thermogravimetry ,Adsorption ,Selective adsorption ,Dendrimer ,Desorption ,Zeta potential ,Environmental Chemistry ,Fourier transform infrared spectroscopy ,0210 nano-technology ,Waste Management and Disposal - Abstract
Carboxymethyl chitosan-modified magnetic-cored dendrimers (CCMDs) were successfully synthesized in a three step method. The synthesized samples were characterized using X-ray diffraction, transmission electron microscopy, scanning electron microscopy, vibrating sample magnetometer, thermogravimetry analysis, zeta potential analyzer, X-ray photoelectron spectroscopy, surface area analysis, and Fourier transform infrared spectroscopy. The CCMD exhibited selective adsorption for anionic and cationic compounds at specific pH conditions. With the substitution of amino groups of MD with carboxymethyl chitosan moieties, the adsorption sites for cationic compounds were greatly increased. Since the adsorption onto CCMD was mainly electrostatic interaction, the adsorption of MB and MO was significantly affected by the pHs. The optimal adsorption pH values were 3 and 11 for MO and MB. The maximal adsorption of MO and MB on the CCMD at pH values of 3 and 11 were 20.85 mg g −1 and 96.31 mg g −1 , respectively. Reuse of the CCMD as an adsorbent was experimentally tested through adsorption and desorption with simple pH control. More than 99% and 91% of the initial adsorption of MB and MO on the CCMD was maintained with five consecutive recycling.
- Published
- 2016
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