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1,186 results on '"Jahn, Reinhard"'

207. Vesicle fusion from yeast to man

Author

Ferro-Novick, Susan and Jahn, Reinhard

Subjects
Mammals -- Anatomy, Neurons -- Physiological aspects, Eukaryotic cells -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Analyses of membrane budding and fusion in mammalian neurons and yeast contradicts the view that fusion events in these eukaryotic cells employ different mechanisms. New theories claim that intracellular membrane fusion events in all eukaryotes employ analogous mechanisms and identical components. Research on the SNARE hypothesis, which identifies these components, will explain eukaryotic fusion mechanisms.

Published
1994

209. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.

Author

Lüningschrör, Patrick, Binotti, Beyenech, Dombert, Benjamin, Heimann, Peter, Perez-Lara, Angel, Slotta, Carsten, Thau-Habermann, Nadine, von Collenberg, Cora R., Karl, Franziska, Damme, Markus, Horowitz, Arie, Maystadt, Isabelle, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Jablonka, Sibylle, Blum, Robert, Üçeyler, Nurcan, Petri, Susanne, Kaltschmidt, Barbara, Jahn, Reinhard, Kaltschmidt, Christian, Sendtner, Michael, Lüningschrör, Patrick, Binotti, Beyenech, Dombert, Benjamin, Heimann, Peter, Perez-Lara, Angel, Slotta, Carsten, Thau-Habermann, Nadine, von Collenberg, Cora R., Karl, Franziska, Damme, Markus, Horowitz, Arie, Maystadt, Isabelle, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Jablonka, Sibylle, Blum, Robert, Üçeyler, Nurcan, Petri, Susanne, Kaltschmidt, Barbara, Jahn, Reinhard, Kaltschmidt, Christian, and Sendtner, Michael

Abstract

Autophagy-mediated degradation of synaptic components maintains synaptic homeostasis but also constitutes a mechanism of neurodegeneration. It is unclear how autophagy of synaptic vesicles and components of presynaptic active zones is regulated. Here, we show that Pleckstrin homology containing family member 5 (Plekhg5) modulates autophagy of synaptic vesicles in axon terminals of motoneurons via its function as a guanine exchange factor for Rab26, a small GTPase that specifically directs synaptic vesicles to preautophagosomal structures. Plekhg5 gene inactivation in mice results in a late-onset motoneuron disease, characterized by degeneration of axon terminals. Plekhg5-depleted cultured motoneurons show defective axon growth and impaired autophagy of synaptic vesicles, which can be rescued by constitutively active Rab26. These findings define a mechanism for regulating autophagy in neurons that specifically targets synaptic vesicles. Disruption of this mechanism may contribute to the pathophysiology of several forms of motoneuron disease.

Published
2017

211. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease

Author

Lüningschrör, Patrick, primary, Binotti, Beyenech, additional, Dombert, Benjamin, additional, Heimann, Peter, additional, Perez-Lara, Angel, additional, Slotta, Carsten, additional, Thau-Habermann, Nadine, additional, R. von Collenberg, Cora, additional, Karl, Franziska, additional, Damme, Markus, additional, Horowitz, Arie, additional, Maystadt, Isabelle, additional, Füchtbauer, Annette, additional, Füchtbauer, Ernst-Martin, additional, Jablonka, Sibylle, additional, Blum, Robert, additional, Üçeyler, Nurcan, additional, Petri, Susanne, additional, Kaltschmidt, Barbara, additional, Jahn, Reinhard, additional, Kaltschmidt, Christian, additional, and Sendtner, Michael, additional

Published
2017
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217. The Habc domain and the SNARE core complex are connected by a highly flexible linker

Author

Margittai, Martin, Fasshauer, Dirk, Jahn, Reinhard, and Langen, Ralf

Subjects
Membrane proteins -- Analysis, Protein folding -- Analysis, Conformational analysis, Structure-activity relationships (Biochemistry) -- Analysis, Biological sciences, Chemistry
Abstract

Electron paramagnetic resonance spectroscopy reveals that the linker region between the Habc domain and the SNARE motif is fully unfolded during the assembly of syntaxin 1 with its SNARE partners. Data indicate that the linker region displays major conformational flexibility.

Published
2003

218. Membrane fusion

Author

Jahn, Reinhard, Lang, Thorsten, and Sudhof, Thomas C.

Subjects
Membranes (Biology) -- Physiological aspects, Membrane fusion -- Physiological aspects, Membrane proteins -- Influence, Lipid membranes, Mechanical chemistry -- Research, Biological sciences
Abstract

This review delineates the membrane fusion process in terms of linear reaction sequences though they do not completely describe the molecular complexity and dynamics of fusion reactions. Research reveals that protein(s) mediate the initial recognition of the membranes to be fused, destabilize the lipid/water interface, and initiate lipid mixing to form a single continuous bilayer.

Published
2003

234. SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

Author

Larhammar, Martin, Patra, Kalicharan, Blunder, Martina, Emilsson, Lina, Peuckert, Christiane, Arvidsson, Emma, Rönnlund, Daniel, Preobraschenski, Julia, Birgner, Carolina, Limbach, Christoph, Widengren, Jerker, Blom, Hans, Jahn, Reinhard, Wallén-Mackenzie, Åsa, Kullander, Klas, Larhammar, Martin, Patra, Kalicharan, Blunder, Martina, Emilsson, Lina, Peuckert, Christiane, Arvidsson, Emma, Rönnlund, Daniel, Preobraschenski, Julia, Birgner, Carolina, Limbach, Christoph, Widengren, Jerker, Blom, Hans, Jahn, Reinhard, Wallén-Mackenzie, Åsa, and Kullander, Klas

Abstract

Background The neuromodulatory transmitters, biogenic amines, have profound effects on multiple neurons and are essential for normal behavior and mental health. Here we report that the orphan transporter SLC10A4, which in the brain is exclusively expressed in presynaptic vesicles of monoaminergic and cholinergic neurons, has a regulatory role in dopamine homeostasis. Methods We used a combination of molecular and behavioral analyses, pharmacology, and in vivo amperometry to assess the role of SLC10A4 in dopamine-regulated behaviors. Results We show that SLC10A4 is localized on the same synaptic vesicles as either vesicular acetylcholine transporter or vesicular monoamine transporter 2. We did not find evidence for direct transport of dopamine by SLC10A4; however, synaptic vesicle preparations lacking SLC10A4 showed decreased dopamine vesicular uptake efficiency. Furthermore, we observed an increased acidification in synaptic vesicles isolated from mice overexpressing SLC10A4. Loss of SLC10A4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio. Absence of SLC10A4 led to slower dopamine clearance rates in vivo, which resulted in accumulation of extracellular dopamine. Finally, whereas SLC10A4 null mutant mice were slightly hypoactive, they displayed hypersensitivity to administration of amphetamine and tranylcypromine. Conclusions Our results demonstrate that SLC10A4 is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation in vivo. The discovery of SLC10A4 and its role in dopaminergic signaling reveals a novel mechanism for neuromodulation and represents an unexplored target for the treatment of neurological and mental disorders.

Published
2015
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235. Reviews of Physiology, Biochemistry and Pharmacology / edited by Bernd Nilius, Thomas Gudermann, Reinhard Jahn, Roland Lill, Ole H. Petersen, Pieter P. de Tombe.

Author

Nilius, Bernd. editor., Gudermann, Thomas. editor., Jahn, Reinhard. editor., Lill, Roland. editor., Petersen, Ole H. editor., de Tombe, Pieter P. editor., SpringerLink (Online service), Nilius, Bernd. editor., Gudermann, Thomas. editor., Jahn, Reinhard. editor., Lill, Roland. editor., Petersen, Ole H. editor., de Tombe, Pieter P. editor., and SpringerLink (Online service)

Abstract

Contents E. Lasic, T. Visnjar, and M. E. Kreft Properties of the urothelium that establish the blood-urine barrier and their implications for drug delivery L.Y.M. Michel, J.G.J. Hoenderop, and R.J.M. Bindels Towards understanding the role of the Na+-Ca2+ exchanger isoform 3 D.F. Hooton, R.G. Lentle, J. Monro, M.S.J. Wickham, and R.M. Simpson The secretion and action of brush border enzymes in the mammalian small intestine .

Published
2015

236. Reviews of Physiology, Biochemistry and Pharmacology Vol. 169 / edited by Bernd Nilius, Thomas Gudermann, Reinhard Jahn, Roland Lill, Ole H. Petersen, Pieter P. de Tombe.

Author

Nilius, Bernd. editor., Gudermann, Thomas. editor., Jahn, Reinhard. editor., Lill, Roland. editor., Petersen, Ole H. editor., de Tombe, Pieter P. editor., SpringerLink (Online service), Nilius, Bernd. editor., Gudermann, Thomas. editor., Jahn, Reinhard. editor., Lill, Roland. editor., Petersen, Ole H. editor., de Tombe, Pieter P. editor., and SpringerLink (Online service)

Abstract

Contens Kristina Friedland and Christian Harteneck Hyperforin - to be or not to be an activator of TRPC(6) Eric Honor , Joana Raquel Martins, David Penton, Amanda Patel, and Sophie Demolombe The Piezo mechanosensitive ion channels: may the force be with you! Jonathan P. Mochel and Meindert Danhof Chronobiology and pharmacologic modulation of the renin-angiotensin aldosterone system in dogs: what have we learnt?

Published
2015

237. Reviews of Physiology, Biochemistry and Pharmacology

Author

Nilius, Bernd., Gudermann, Thomas., Jahn, Reinhard., Lill, Roland., Petersen, Ole H., de Tombe, Pieter P., Nilius, Bernd., Gudermann, Thomas., Jahn, Reinhard., Lill, Roland., Petersen, Ole H., and de Tombe, Pieter P.

Published
2015

238. Reviews of Physiology, Biochemistry and Pharmacology Vol. 169

Author

Nilius, Bernd., Gudermann, Thomas., Jahn, Reinhard., Lill, Roland., Petersen, Ole H., de Tombe, Pieter P., Nilius, Bernd., Gudermann, Thomas., Jahn, Reinhard., Lill, Roland., Petersen, Ole H., and de Tombe, Pieter P.

Published
2015

239. Synaptic vesicle fusion: today and beyond

Author

Brose, Nils, Brunger, Axel, Cafiso, David, Chapman, Edwin, Diao, Jiajie, Hughson, Frederick, Jackson, Meyer, Jahn, Reinhard, Lindau, Manfred, Ma, Cong, Rizo, Josep, Shin, Yeon-Kyun, Söllner, Thomas, Tamm, Lukas, Yoon, Tae-Young, and Zhang, Yongli

Abstract

Researchers working on synaptic vesicle fusion and neurotransmitter release share their views on the most interesting developments in their field and the challenges that lie ahead.

Published
2019
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240. Author Correction: Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies.

Author

Birinci, Yelda, Preobraschenski, Julia, Ganzella, Marcelo, Jahn, Reinhard, and Park, Yongsoo

Subjects
FLUORESCENCE resonance energy transfer
Abstract

Fusion was measured by dequenching of labeled membrane lipids (lipid mixing)18,22,28 (top). Plasma membrane-mimicking liposomes contain phospholipids labelled with NBD (green fluorescence) and rhodamine (red fluorescence). Fluorescence resonance energy transfer (FRET) between the two fluorophore-labeled lipids is reduced after LDCV fusion due to lipid dilution by unlabeled lipids of LDCVs, thus de-quenching the donor fluorescence. [Extracted from the article]

Published
2022
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242. Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength

Author

Park, Yongsoo, primary, Seo, Jong Bae, additional, Fraind, Alicia, additional, Pérez-Lara, Angel, additional, Yavuz, Halenur, additional, Han, Kyungreem, additional, Jung, Seung-Ryoung, additional, Kattan, Iman, additional, Walla, Peter Jomo, additional, Choi, MooYoung, additional, Cafiso, David S, additional, Koh, Duk-Su, additional, and Jahn, Reinhard, additional

Published
2015
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248. SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

Author

Larhammar, Martin, primary, Patra, Kalicharan, additional, Blunder, Martina, additional, Emilsson, Lina, additional, Peuckert, Christiane, additional, Arvidsson, Emma, additional, Rönnlund, Daniel, additional, Preobraschenski, Julia, additional, Birgner, Carolina, additional, Limbach, Christoph, additional, Widengren, Jerker, additional, Blom, Hans, additional, Jahn, Reinhard, additional, Wallén-Mackenzie, Åsa, additional, and Kullander, Klas, additional

Published
2015
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249. The GTPase Rab26 links synaptic vesicles to the autophagy pathway

Author

Binotti, Beyenech, primary, Pavlos, Nathan J, additional, Riedel, Dietmar, additional, Wenzel, Dirk, additional, Vorbrüggen, Gerd, additional, Schalk, Amanda M, additional, Kühnel, Karin, additional, Boyken, Janina, additional, Erck, Christian, additional, Martens, Henrik, additional, Chua, John JE, additional, and Jahn, Reinhard, additional

Published
2015
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250. Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains

Author

Milovanovic, Dragomir, primary, Honigmann, Alf, additional, Koike, Seiichi, additional, Göttfert, Fabian, additional, Pähler, Gesa, additional, Junius, Meike, additional, Müllar, Stefan, additional, Diederichsen, Ulf, additional, Janshoff, Andreas, additional, Grubmüller, Helmut, additional, Risselada, Herre J., additional, Eggeling, Christian, additional, Hell, Stefan W., additional, van den Bogaart, Geert, additional, and Jahn, Reinhard, additional

Published
2015
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