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202. Ethanol intake and risk of lung cancer in the European prospective investigation into cancer and nutrition (EPIC)

Author

Rohrmann, Sabine Linseisen, Jakob Boshuizen, Hendriek C. and Whittaker, John Agudo, Antonio Vineis, Paolo Boffetta, Paolo and Jensen, Majken K. Olsen, Anja Overvad, Kim Tjonneland, Anne Boutron-Ruault, Marie-Christine Clavel-Chapelon, Francoise and Bergmann, Manuela M. Boeing, Heiner Allen, Naomi Key, Tim Bingham, Sheila Khaw, Kay-Tee Kyriazi, Georgia and Soukara, Stavroula Trichopoulou, Antonia Panico, Salvatore and Palli, Domenico Sieri, Sabina Tumino, Rosario Peeters, Petra H. M. Bueno-de-Mesquita, H. Bas Buchner, Frederike L. Gram, Inger Torhild Lund, Eiliv Ardanaz, Eva Chirlaque, Maria-Dolores Dorronsoro, Miren Sanchez Perez, Maria-Jose and Quiros, Jose R. Berglund, GorRan Janzon, Lars Rasmuson, Torgny Weinehall, Lars Ferrari, Pietro Jenab, Mazda and Norat, Teresa Riboli, Elio

Abstract

Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (>= 60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

Published
2006

203. Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain.

Author

Tiange Wang, Tao Huang, Yoriko Heianza, Dianjianyi Sun, Yan Zheng, Wenjie Ma, Jensen, Majken K., Kang, Jae H., Wiggs, Janey L., Pasquale, Louis R., Rimm, Eric B., Manson, JoAnn E., Hu, Frank B., Willett, Walter C., Lu Qi, Wang, Tiange, Huang, Tao, Heianza, Yoriko, Sun, Dianjianyi, and Zheng, Yan

Subjects
PHYSICAL activity, WEIGHT gain, BODY mass index, SINGLE nucleotide polymorphisms, FAT, BODY composition, GENETICS, BODY weight, DISEASE susceptibility, EXERCISE, LONGITUDINAL method, RESEARCH funding
Abstract

Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a BMI-genetic risk score (GRS) based on 77 BMI-associated single nucleotide polymorphisms (SNPs) and a body fat percentage (BF%)-GRS based on 12 BF%-associated SNPs in 9,390 women from the Nurses' Health Study (NHS) and 5,291 men from the Health Professionals Follow-Up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses. Both the BMI-GRS and the BF%-GRS were associated with long-term increases in BMI/weight, and change in physical activity consistently interacted with the BF%-GRS on BMI change in the NHS (P for interaction = 0.025) and HPFS (P for interaction = 0.001). In the combined cohorts, 4-year BMI change per 10-risk allele increment was -0.02 kg/m2 among participants with greatest increase in physical activity and 0.24 kg/m2 among those with greatest decrease in physical activity (P for interaction < 0.001), corresponding to 0.01 kg versus 0.63 kg weight changes every 4 years (P for interaction = 0.001). Similar but marginal interactions were observed for the BMI-GRS (P for interaction = 0.045). Our data indicate that the genetic susceptibility to weight gain may be diminished by increasing physical activity. [ABSTRACT FROM AUTHOR]

Published
2017
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204. Apolipoprotein C-III and High-Density Lipoprotein Subspecies Defined by Apolipoprotein C-III in Relation to Diabetes Risk.

Author

Aroner, Sarah A., Ming Yang, Junlong Li, Furtado, Jeremy D., Sacks, Frank M., Tjønneland, Anne, Overvad, Kim, Tianxi Cai, and Jensen, Majken K.

Subjects
DIABETES risk factors, APOLIPOPROTEINS, BIOMARKERS, CONFIDENCE intervals, DIABETES, HIGH density lipoproteins, PROBABILITY theory, RISK assessment, PROPORTIONAL hazards models, DESCRIPTIVE statistics
Abstract

Apolipoprotein C-III (apoC-III) is a potential novel biomarker that may play an important role in the pathogenesis of diabetes, particularly when present on high-density lipoprotein (HDL). In a case-cohort design among 3,101 non-cases and 434 incident diabetes cases occurring before 2007 in the Danish Diet, Cancer, and Health study, we examined associations of baseline (1993-1997) plasma concentrations of apoC-III and subspecies of HDL defined by the presence or absence of apoC-III with risk of diabetes using Cox regression. ApoC-III was strongly associated with risk of diabetes (hazard ratio [HR], top vs. bottom quintile = 3.43; 95% CI: 1.75, 6.70; P-trend < 0.001). The cholesterol concentration of HDL (HDL-C) without apoC-III was inversely associated with risk of diabetes (HR = 0.48; 95% CI: 0.27, 0.85; P-trend = 0.002), more so than total HDL-C (HR = 0.60; 95% CI: 0.35, 1.03; P-trend = 0.04), whereas HDL-C with apoC-III was not associated (HR = 1.05; 95% CI: 0.50, 2.21; P-trend = 0.44) (P-heterogeneity, HDL-C with and without apoC-III = 0.002). ApoC-III itself is a strong risk marker for diabetes, and its presence on HDL may impair the anti-diabetogenic properties of HDL. ApoC-III has potential to be a therapeutic target for the prevention of diabetes. [ABSTRACT FROM AUTHOR]

Published
2017
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205. Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Author

Jensen, Majken K., Jensen, Richard A., Mukamal, Kenneth J., Xiuqing Guo, Jie Yao, Qi Sun, Marilyn Cornelis, Yongmei Liu, Ming-Huei Chen, Kizer, Jorge R., Luc Djoussé, Siscovick, David S., Psaty, Bruce M., Zmuda, Joseph M., Rotter, Jerome I., Garcia, Melissa, Harris, Tamara, Ida Chen, Goodarzi, Mark O., and Nalls, Michael A.

Published
2017
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206. Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies.

Author

Tiange Wang, Tao Huang, Kang, Jae H., Yan Zheng, Jensen, Majken K., Wiggs, Janey L., Pasquale, Louis R., Fuchs, Charles S., Campos, Hannia, Rimm, Eric B., Willett, Walter C., Hu, Frank B., Lu Qi, Wang, Tiange, Huang, Tao, Zheng, Yan, and Qi, Lu

Subjects
PHYSIOLOGICAL effects of coffee, OVERWEIGHT persons, PHYSIOLOGICAL effects of caffeine, BODY mass index, WOMEN'S health, HEALTH, PREVENTION of obesity, COFFEE, DIET, DISEASE susceptibility, LONGITUDINAL method, OBESITY, RESEARCH funding
Abstract

Background: Whether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown.Methods: We analyzed the interactions between genetic predisposition and habitual coffee consumption in relation to BMI and obesity risk in 5116 men from the Health Professionals Follow-up Study (HPFS), in 9841 women from the Nurses' Health Study (NHS), and in 5648 women from the Women's Health Initiative (WHI). The genetic risk score was calculated based on 77 BMI-associated loci. Coffee consumption was examined prospectively in relation to BMI.Results: The genetic association with BMI was attenuated among participants with higher consumption of coffee than among those with lower consumption in the HPFS (P interaction  = 0.023) and NHS (P interaction  = 0.039); similar results were replicated in the WHI (P interaction  = 0.044). In the combined data of all cohorts, differences in BMI per increment of 10-risk allele were 1.38 (standard error (SE), 0.28), 1.02 (SE, 0.10), and 0.95 (SE, 0.12) kg/m2 for coffee consumption of < 1, 1-3 and > 3 cup(s)/day, respectively (P interaction  < 0.001). Such interaction was partly due to slightly higher BMI with higher coffee consumption among participants at lower genetic risk and slightly lower BMI with higher coffee consumption among those at higher genetic risk. Each increment of 10-risk allele was associated with 78% (95% confidence interval (CI), 59-99%), 48% (95% CI, 36-62%), and 43% (95% CI, 28-59%) increased risk for obesity across these subgroups of coffee consumption (P interaction  = 0.008). From another perspective, differences in BMI per increment of 1 cup/day coffee consumption were 0.02 (SE, 0.09), -0.02 (SE, 0.04), and -0.14 (SE, 0.04) kg/m2 across tertiles of the genetic risk score.Conclusions: Higher coffee consumption might attenuate the genetic associations with BMI and obesity risk, and individuals with greater genetic predisposition to obesity appeared to have lower BMI associated with higher coffee consumption. [ABSTRACT FROM AUTHOR]

Published
2017
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207. Fetuin-A and Risk of Diabetes Independent of Liver Fat Content.

Author

Aroner, Sarah A., Mukamal, Kenneth J., St-Jules, David E., Budoff, Matthew J., Katz, Ronit, Criqui, Michael H., Allison, Matthew A., de Boer, Ian H., Siscovick, David S., Ix, Joachim H., and Jensen, Majken K.

Subjects
DIABETES risk factors, LIVER physiology, SMOKING, FAT analysis, BIOMARKERS, BLACK people, BLOOD pressure, C-reactive protein, CHINESE people, CHOLESTEROL, COMPUTED tomography, CONFIDENCE intervals, ALCOHOL drinking, EDUCATION, ETHNIC groups, FATTY liver, GLOMERULAR filtration rate, HIGH density lipoproteins, HISPANIC Americans, HOMEOSTASIS, PATIENT aftercare, INCOME, LONGITUDINAL method, LOW density lipoproteins, MEDICAL cooperation, PROTEINS, RESEARCH, RESEARCH funding, TRIGLYCERIDES, WHITE people, BODY mass index, PROPORTIONAL hazards models, PATIENT selection, POSTMENOPAUSE, PHYSICAL activity
Abstract

Fetuin-A is a hepatic secretory protein and a novel risk factor for diabetes. However, it remains unclear whether the association between high levels of fetuin-A and diabetes can be attributed to nonalcoholic fatty liver disease. We conducted a case-cohort study among 1,957 subcohort members and 455 incident diabetes cases in the Multi-Ethnic Study of Atherosclerosis, a multicenter US study of Caucasian, African-American, Hispanic, and Chinese-American adults aged 45-84 years. Serum fetuin-A and computed tomography-determined liver fat content were measured from samples collected at baseline (2000-2002). In multivariable Cox proportional hazards models with follow-up through 2012, a higher fetuin-A level was associated with a higher risk of diabetes, with a stronger association among women (for top quartile vs. bottom, hazard ratio (HR) = 3.36, 95% confidence interval (CI): 2.08, 5.44) than among men (HR = 1.47, 95% CI: 0.93, 2.35) (P-heterogeneity = 0.001). Adjustment for liver fat content attenuated these associations slightly (women: HR = 2.61, 95% CI: 1.59, 4.26; men: HR = 1.32, 95% CI: 0.84, 2.08). In this study, we observed a particularly strong association of fetuin-A with diabetes risk in women that could not be explained by liver fat. [ABSTRACT FROM AUTHOR]

Published
2017
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208. Robust risk prediction with biomarkers under two-phase stratified cohort design.

Author

Payne, Rebecca, Yang, Ming, Zheng, Yingye, Jensen, Majken K., and Cai, Tianxi

Subjects
BIOMARKERS, PREDICTION models, DISEASE risk factors, STATISTICAL sampling, REGRESSION analysis
Abstract

Identification of novel biomarkers for risk prediction is important for disease prevention and optimal treatment selection. However, studies aiming to discover which biomarkers are useful for risk prediction often require the use of stored biological samples from large assembled cohorts, and thus the depletion of a finite and precious resource. To make efficient use of such stored samples, two-phase sampling designs are often adopted as resource-efficient sampling strategies, especially when the outcome of interest is rare. Existing methods for analyzing data from two-phase studies focus primarily on single marker analysis or fitting the Cox regression model to combine information from multiple markers. However, the Cox model may not fit the data well. Under model misspecification, the composite score derived from the Cox model may not perform well in predicting the outcome. Under a general two-phase stratified cohort sampling design, we present a novel approach to combining multiple markers to optimize prediction by fitting a flexible nonparametric transformation model. Using inverse probability weighting to account for the outcome-dependent sampling, we propose to estimate the model parameters by maximizing an objective function which can be interpreted as a weighted C-statistic for survival outcomes. Regardless of model adequacy, the proposed procedure yields a sensible composite risk score for prediction. A major obstacle for making inference under two phase studies is due to the correlation induced by the finite population sampling, which prevents standard inference procedures such as the bootstrap from being used for variance estimation. We propose a resampling procedure to derive valid confidence intervals for the model parameters and the C-statistic accuracy measure. We illustrate the new methods with simulation studies and an analysis of a two-phase study of high-density lipoprotein cholesterol (HDL-C) subtypes for predicting the risk of coronary heart disease. [ABSTRACT FROM AUTHOR]

Published
2016
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209. En prospektiv undersøgelse af sammenhaengen mellem rygning og senere alkoholstorforbrug i den danske befolkning

Author

Jensen, Majken K, Sørensen, Thorkild I A, Andersen, Anne T, Thorsen, Thorkil, Tolstrup, Janne S, Godtfredsen, Nina S, and Grønbaek, Morten N

Subjects
Adult, Male, Questionnaires, genetic structures, Alcohol Drinking, Dose-Response Relationship, Drug, Denmark, Smoking, Middle Aged, eye diseases, Alcoholism, Risk Factors, Odds Ratio, Humans, Female, sense organs, Prospective Studies, Aged
Abstract

Udgivelsesdato: 2004-Oct-11

Published
2004

211. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author

Qi, Qibin, primary, Kilpeläinen, Tuomas O., additional, Downer, Mary K., additional, Tanaka, Toshiko, additional, Smith, Caren E., additional, Sluijs, Ivonne, additional, Sonestedt, Emily, additional, Chu, Audrey Y., additional, Renström, Frida, additional, Lin, Xiaochen, additional, Ängquist, Lars H., additional, Huang, Jinyan, additional, Liu, Zhonghua, additional, Li, Yanping, additional, Asif Ali, Muhammad, additional, Xu, Min, additional, Ahluwalia, Tarunveer Singh, additional, Boer, Jolanda M.A., additional, Chen, Peng, additional, Daimon, Makoto, additional, Eriksson, Johan, additional, Perola, Markus, additional, Friedlander, Yechiel, additional, Gao, Yu-Tang, additional, Heppe, Denise H.M., additional, Holloway, John W., additional, Houston, Denise K., additional, Kanoni, Stavroula, additional, Kim, Yu-Mi, additional, Laaksonen, Maarit A., additional, Jääskeläinen, Tiina, additional, Lee, Nanette R., additional, Lehtimäki, Terho, additional, Lemaitre, Rozenn N., additional, Lu, Wei, additional, Luben, Robert N., additional, Manichaikul, Ani, additional, Männistö, Satu, additional, Marques-Vidal, Pedro, additional, Monda, Keri L., additional, Ngwa, Julius S., additional, Perusse, Louis, additional, van Rooij, Frank J.A., additional, Xiang, Yong-Bing, additional, Wen, Wanqing, additional, Wojczynski, Mary K, additional, Zhu, Jingwen, additional, Borecki, Ingrid B., additional, Bouchard, Claude, additional, Cai, Qiuyin, additional, Cooper, Cyrus, additional, Dedoussis, George V., additional, Deloukas, Panos, additional, Ferrucci, Luigi, additional, Forouhi, Nita G., additional, Hansen, Torben, additional, Christiansen, Lene, additional, Hofman, Albert, additional, Johansson, Ingegerd, additional, Jørgensen, Torben, additional, Karasawa, Shigeru, additional, Khaw, Kay-Tee, additional, Kim, Mi-Kyung, additional, Kristiansson, Kati, additional, Li, Huaixing, additional, Lin, Xu, additional, Liu, Yongmei, additional, Lohman, Kurt K., additional, Long, Jirong, additional, Mikkilä, Vera, additional, Mozaffarian, Dariush, additional, North, Kari, additional, Pedersen, Oluf, additional, Raitakari, Olli, additional, Rissanen, Harri, additional, Tuomilehto, Jaakko, additional, van der Schouw, Yvonne T., additional, Uitterlinden, André G., additional, Zillikens, M. Carola, additional, Franco, Oscar H., additional, Shyong Tai, E., additional, Ou Shu, Xiao, additional, Siscovick, David S., additional, Toft, Ulla, additional, Verschuren, W.M. Monique, additional, Vollenweider, Peter, additional, Wareham, Nicholas J., additional, Witteman, Jacqueline C.M., additional, Zheng, Wei, additional, Ridker, Paul M., additional, Kang, Jae H., additional, Liang, Liming, additional, Jensen, Majken K., additional, Curhan, Gary C., additional, Pasquale, Louis R., additional, Hunter, David J., additional, Mohlke, Karen L., additional, Uusitupa, Matti, additional, Cupples, L. Adrienne, additional, Rankinen, Tuomo, additional, Orho-Melander, Marju, additional, Wang, Tao, additional, Chasman, Daniel I., additional, Franks, Paul W., additional, Sørensen, Thorkild I.A., additional, Hu, Frank B., additional, Loos, Ruth J. F., additional, Nettleton, Jennifer A., additional, and Qi, Lu, additional

Published
2014
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213. Abstract P025: Associations of Fetuin-A with Incident Heart Failure in Participants with and without Diabetes and Insulin Resistance: The Cardiovascular Health Study

Author

Forbang, Nketi I, primary, Bartz, Traci M, additional, Mukamal, Kenneth J, additional, Djousse, Luc, additional, Kizer, Jorge R, additional, Zieman, Sue J, additional, Siscovick, David S, additional, Jensen, Majken K, additional, Shlipak, Michael, additional, and Ix, Joachim H, additional

Published
2014
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214. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Author

den Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U., Kutalik, Zoltan, Luan, Jian'an, Kemp, John P., Kristiansson, Kati, Ladenvall, Claes, Lorentzon, Mattias, Montasser, May E., Njajou, Omer T., O'Reilly, Paul F., Padmanabhan, Sandosh, Pourcain, Beate St., Rankinen, Tuomo, Salo, Perttu, Tanaka, Toshiko, Timpson, Nicholas J., Vitart, Veronique, Waite, Lindsay, Wheeler, William, Zhang, Weihua, Draisma, Harmen H. M., Feitosa, Mary F., Kerr, Kathleen F., Lind, Penelope A., Mihailov, Evelin, Onland-Moret, N. Charlotte, Song, Ci, Weedon, Michael N., Xie, Weijia, Yengo, Loic, Absher, Devin, Albert, Christine M., Alonso, Alvaro, Arking, Dan E., de Bakker, Paul I. W., Balkau, Beverley, Barlassina, Cristina, Benaglio, Paola, Bis, Joshua C., Bouatia-Naji, Nabila, Brage, Soren, Chanock, Stephen J., Chines, Peter S., Chung, Mina, Darbar, Dawood, Dina, Christian, Doerr, Marcus, Elliott, Paul, Felix, Stephan B., Fischer, Krista, Fuchsberger, Christian, de Geus, Eco J. C., Goyette, Philippe, Gudnason, Vilmundur, Harris, Tamara B., Hartikainen, Anna-Liisa, Havulinna, Aki S., Heckbert, Susan R., Hicks, Andrew A., Hofman, Albert, Holewijn, Suzanne, Hoogstra-Berends, Femke, Hottenga, Jouke-Jan, Jensen, Majken K., Johansson, Asa, Junttila, Juhani, Kaeaeb, Stefan, Kanon, Bart, Ketkar, Shamika, Khaw, Kay-Tee, Knowles, Joshua W., Kooner, Angrad S., Kors, Jan A., Kumari, Meena, Milani, Lili, Laiho, Paeivi, Lakatta, Edward G., Langenberg, Claudia, Leusink, Maarten, Liu, Yongmei, Luben, Robert N., Lunetta, Kathryn L., Lynch, Stacey N., Markus, Marcello R. P., Marques-Vidal, Pedro, Leach, Irene Mateo, McArdle, Wendy L., McCarroll, Steven A., Medland, Sarah E., Miller, Kathryn A., Montgomery, Grant W., Morrison, Alanna C., Mueller-Nurasyid, Martina, Navarro, Pau, Nelis, Mari, O'Connell, Jeffrey R., O'Donnell, Christopher J., Ong, Ken K., Newman, Anne B., Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Psaty, Bruce M., Rao, Dabeeru C., Ring, Susan M., Rossin, Elizabeth J., Rudan, Diana, Sanna, Serena, Scott, Robert A., Sehmi, Jaban S., Sharp, Stephen, Shin, Jordan T., Singleton, Andrew B., Smith, Albert V., Soranzo, Nicole, Spector, Tim D., Stewart, Chip, Stringham, Heather M., Tarasov, Kirill V., Uitterlinden, Andre G., Vandenput, Liesbeth, Hwang, Shih-Jen, Whitfield, John B., Wijmenga, Cisca, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Witteman, Jacqueline C. M., Wong, Andrew, Wong, Quenna, Jamshidi, Yalda, Zitting, Paavo, Boer, Jolanda M. A., Boomsma, Dorret I., Borecki, Ingrid B., van Duijn, Cornelia M., Ekelund, Ulf, Forouhi, Nita G., Froguel, Philippe, Hingorani, Aroon, Ingelsson, Erik, Kivimaki, Mika, Kronmal, Richard A., Kuh, Diana, Lind, Lars, Martin, Nicholas G., Oostra, Ben A., Pedersen, Nancy L., Quertermous, Thomas, Rotter, Jerome I., van der Schouw, Yvonne T., Verschuren, W. M. Monique, Walker, Mark, Albanes, Demetrius, Arnar, David O., Assimes, Themistocles L., Bandinelli, Stefania, Boehnke, Michael, de Boer, Rudolf A., Bouchard, Claude, Caulfield, W. L. Mark, Chambers, John C., Curhan, Gary, Cusi, Daniele, Eriksson, Johan, Ferrucci, Luigi, van Gilst, Wiek H., Glorioso, Nicola, de Graaf, Jacqueline, Groop, Leif, Gyllensten, Ulf, Hsueh, Wen-Chi, Hu, Frank B., Huikuri, Heikki V., Hunter, David J., Iribarren, Carlos, Isomaa, Bo, Jarvelin, Marjo-Riitta, Jula, Antti, Kahonen, Mika, Kiemeney, Lambertus A., van der Klauw, Melanie M., Kooner, Jaspal S., Kraft, Peter, Iacoviello, Licia, Lehtimaki, Terho, Lokki, Marja-Liisa L., Mitchell, Braxton D., Navis, Gerjan, Nieminen, Markku S., Ohlsson, Claes, Poulter, Neil R., Qi, Lu, Raitakari, Olli T., Rimm, Eric B., Rioux, John D., Rizzi, Federica, Rudan, Igor, Salomaa, Veikko, Sever, Peter S., Shields, Denis C., Shuldiner, Alan R., Sinisalo, Juha, Stanton, Alice V., Stolk, Ronald P., Strachan, David P., Tardif, Jean-Claude, Thorsteinsdottir, Unnur, Tuomilehto, Jaako, van Veldhuisen, Dirk J., Virtamo, Jarmo, Viikari, Jorma, Vollenweider, Peter, Waeber, Gerard, Widen, Elisabeth, Cho, Yoon Shin, Olsen, Jesper V., Visscher, Peter M., Willer, Cristen, Franke, Lude, Erdmann, Jeanette, Thompson, John R., Pfeufer, Arne, Sotoodehnia, Nona, Newton-Cheh, Christopher, Ellinor, Patrick T., Stricker, Bruno H. Ch, Metspalu, Andres, Perola, Markus, Beckmann, Jacques S., Smith, George Davey, Stefansson, Kari, Wareham, Nicholas J., Munroe, Patricia B., Sibon, Ody C. M., Milan, David J., Snieder, Harold, Samani, Nilesh J., Loos, Ruth J. F., den Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U., Kutalik, Zoltan, Luan, Jian'an, Kemp, John P., Kristiansson, Kati, Ladenvall, Claes, Lorentzon, Mattias, Montasser, May E., Njajou, Omer T., O'Reilly, Paul F., Padmanabhan, Sandosh, Pourcain, Beate St., Rankinen, Tuomo, Salo, Perttu, Tanaka, Toshiko, Timpson, Nicholas J., Vitart, Veronique, Waite, Lindsay, Wheeler, William, Zhang, Weihua, Draisma, Harmen H. M., Feitosa, Mary F., Kerr, Kathleen F., Lind, Penelope A., Mihailov, Evelin, Onland-Moret, N. Charlotte, Song, Ci, Weedon, Michael N., Xie, Weijia, Yengo, Loic, Absher, Devin, Albert, Christine M., Alonso, Alvaro, Arking, Dan E., de Bakker, Paul I. W., Balkau, Beverley, Barlassina, Cristina, Benaglio, Paola, Bis, Joshua C., Bouatia-Naji, Nabila, Brage, Soren, Chanock, Stephen J., Chines, Peter S., Chung, Mina, Darbar, Dawood, Dina, Christian, Doerr, Marcus, Elliott, Paul, Felix, Stephan B., Fischer, Krista, Fuchsberger, Christian, de Geus, Eco J. C., Goyette, Philippe, Gudnason, Vilmundur, Harris, Tamara B., Hartikainen, Anna-Liisa, Havulinna, Aki S., Heckbert, Susan R., Hicks, Andrew A., Hofman, Albert, Holewijn, Suzanne, Hoogstra-Berends, Femke, Hottenga, Jouke-Jan, Jensen, Majken K., Johansson, Asa, Junttila, Juhani, Kaeaeb, Stefan, Kanon, Bart, Ketkar, Shamika, Khaw, Kay-Tee, Knowles, Joshua W., Kooner, Angrad S., Kors, Jan A., Kumari, Meena, Milani, Lili, Laiho, Paeivi, Lakatta, Edward G., Langenberg, Claudia, Leusink, Maarten, Liu, Yongmei, Luben, Robert N., Lunetta, Kathryn L., Lynch, Stacey N., Markus, Marcello R. P., Marques-Vidal, Pedro, Leach, Irene Mateo, McArdle, Wendy L., McCarroll, Steven A., Medland, Sarah E., Miller, Kathryn A., Montgomery, Grant W., Morrison, Alanna C., Mueller-Nurasyid, Martina, Navarro, Pau, Nelis, Mari, O'Connell, Jeffrey R., O'Donnell, Christopher J., Ong, Ken K., Newman, Anne B., Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Psaty, Bruce M., Rao, Dabeeru C., Ring, Susan M., Rossin, Elizabeth J., Rudan, Diana, Sanna, Serena, Scott, Robert A., Sehmi, Jaban S., Sharp, Stephen, Shin, Jordan T., Singleton, Andrew B., Smith, Albert V., Soranzo, Nicole, Spector, Tim D., Stewart, Chip, Stringham, Heather M., Tarasov, Kirill V., Uitterlinden, Andre G., Vandenput, Liesbeth, Hwang, Shih-Jen, Whitfield, John B., Wijmenga, Cisca, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Witteman, Jacqueline C. M., Wong, Andrew, Wong, Quenna, Jamshidi, Yalda, Zitting, Paavo, Boer, Jolanda M. A., Boomsma, Dorret I., Borecki, Ingrid B., van Duijn, Cornelia M., Ekelund, Ulf, Forouhi, Nita G., Froguel, Philippe, Hingorani, Aroon, Ingelsson, Erik, Kivimaki, Mika, Kronmal, Richard A., Kuh, Diana, Lind, Lars, Martin, Nicholas G., Oostra, Ben A., Pedersen, Nancy L., Quertermous, Thomas, Rotter, Jerome I., van der Schouw, Yvonne T., Verschuren, W. M. Monique, Walker, Mark, Albanes, Demetrius, Arnar, David O., Assimes, Themistocles L., Bandinelli, Stefania, Boehnke, Michael, de Boer, Rudolf A., Bouchard, Claude, Caulfield, W. L. Mark, Chambers, John C., Curhan, Gary, Cusi, Daniele, Eriksson, Johan, Ferrucci, Luigi, van Gilst, Wiek H., Glorioso, Nicola, de Graaf, Jacqueline, Groop, Leif, Gyllensten, Ulf, Hsueh, Wen-Chi, Hu, Frank B., Huikuri, Heikki V., Hunter, David J., Iribarren, Carlos, Isomaa, Bo, Jarvelin, Marjo-Riitta, Jula, Antti, Kahonen, Mika, Kiemeney, Lambertus A., van der Klauw, Melanie M., Kooner, Jaspal S., Kraft, Peter, Iacoviello, Licia, Lehtimaki, Terho, Lokki, Marja-Liisa L., Mitchell, Braxton D., Navis, Gerjan, Nieminen, Markku S., Ohlsson, Claes, Poulter, Neil R., Qi, Lu, Raitakari, Olli T., Rimm, Eric B., Rioux, John D., Rizzi, Federica, Rudan, Igor, Salomaa, Veikko, Sever, Peter S., Shields, Denis C., Shuldiner, Alan R., Sinisalo, Juha, Stanton, Alice V., Stolk, Ronald P., Strachan, David P., Tardif, Jean-Claude, Thorsteinsdottir, Unnur, Tuomilehto, Jaako, van Veldhuisen, Dirk J., Virtamo, Jarmo, Viikari, Jorma, Vollenweider, Peter, Waeber, Gerard, Widen, Elisabeth, Cho, Yoon Shin, Olsen, Jesper V., Visscher, Peter M., Willer, Cristen, Franke, Lude, Erdmann, Jeanette, Thompson, John R., Pfeufer, Arne, Sotoodehnia, Nona, Newton-Cheh, Christopher, Ellinor, Patrick T., Stricker, Bruno H. Ch, Metspalu, Andres, Perola, Markus, Beckmann, Jacques S., Smith, George Davey, Stefansson, Kari, Wareham, Nicholas J., Munroe, Patricia B., Sibon, Ody C. M., Milan, David J., Snieder, Harold, Samani, Nilesh J., and Loos, Ruth J. F.

Abstract

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.

Published
2013
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215. Gene x Physical Activity Interactions in Obesity : Combined Analysis of 111,421 Individuals of European Ancestry

Author

Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V., Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W., Chu, Audrey Y., Rose, Lynda M., Ganna, Andrea, Qi, Qibin, Stancakova, Alena, Sandholt, Camilla H., Elks, Cathy E., Curhan, Gary, Jensen, Majken K., Tamimi, Rulla M., Allin, Kristine H., Jorgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Pare, Guillaume, Magnusson, Patrik K. E., Pedersen, Nancy L., Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L., Pasquale, Louis T., Pedersen, Oluf, Scott, Robert A., Ridker, Paul M., Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J., Chasman, Daniel I., Hallmans, Goran, Hu, Frank B., Renstrom, Frida, Orho-Melander, Marju, Franks, Paul W., Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V., Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W., Chu, Audrey Y., Rose, Lynda M., Ganna, Andrea, Qi, Qibin, Stancakova, Alena, Sandholt, Camilla H., Elks, Cathy E., Curhan, Gary, Jensen, Majken K., Tamimi, Rulla M., Allin, Kristine H., Jorgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Pare, Guillaume, Magnusson, Patrik K. E., Pedersen, Nancy L., Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L., Pasquale, Louis T., Pedersen, Oluf, Scott, Robert A., Ridker, Paul M., Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J., Chasman, Daniel I., Hallmans, Goran, Hu, Frank B., Renstrom, Frida, Orho-Melander, Marju, and Franks, Paul W.

Abstract

Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. Twelve obesity-susceptibility loci were genotyped or imputed in 111,421 participants. A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. Physical activity was assessed using self-administered questionnaires. Multiplicative interactions between the GRS and physical activity on BMI were tested in linear and logistic regression models in each cohort, with adjustment for age, age(2), sex, study center (for multicenter studies), and the marginal terms for physical activity and the GRS. These results were combined using meta-analysis weighted by cohort sample size. The meta-analysis yielded a statistically significant GRS x physical activity interaction effect estimate (P-interaction = 0.015). However, a statistically significant interaction effect was only apparent in North American cohorts (n = 39,810, P-interaction = 0.014 vs. n = 71,611, P-interaction = 0.275 for Europeans). In secondary analyses, both the FTO rs1121980 (P-interaction = 0.003) and the SEC16B rs10913469 (P-interaction = 0.025) variants showed evidence of SNP x physical activity interactions. This meta-analysis of 111,421 individuals provides further support for an interaction between physical activity and a GRS in obesity disposition, although these findings hinge on the inclusion of cohorts from North America, indicating that these results are either population-specific or non-causal.

Published
2013
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216. A genome-wide association study of depressive symptoms.

Author

Hek, Karin, Hek, Karin, Demirkan, Ayse, Lahti, Jari, Terracciano, Antonio, Teumer, Alexander, Cornelis, Marilyn C, Amin, Najaf, Bakshis, Erin, Baumert, Jens, Ding, Jingzhong, Liu, Yongmei, Marciante, Kristin, Meirelles, Osorio, Nalls, Michael A, Sun, Yan V, Vogelzangs, Nicole, Yu, Lei, Bandinelli, Stefania, Benjamin, Emelia J, Bennett, David A, Boomsma, Dorret, Cannas, Alessandra, Coker, Laura H, de Geus, Eco, De Jager, Philip L, Diez-Roux, Ana V, Purcell, Shaun, Hu, Frank B, Rimma, Eric B, Hunter, David J, Jensen, Majken K, Curhan, Gary, Rice, Kenneth, Penman, Alan D, Rotter, Jerome I, Sotoodehnia, Nona, Emeny, Rebecca, Eriksson, Johan G, Evans, Denis A, Ferrucci, Luigi, Fornage, Myriam, Gudnason, Vilmundur, Hofman, Albert, Illig, Thomas, Kardia, Sharon, Kelly-Hayes, Margaret, Koenen, Karestan, Kraft, Peter, Kuningas, Maris, Massaro, Joseph M, Melzer, David, Mulas, Antonella, Mulder, Cornelis L, Murray, Anna, Oostra, Ben A, Palotie, Aarno, Penninx, Brenda, Petersmann, Astrid, Pilling, Luke C, Psaty, Bruce, Rawal, Rajesh, Reiman, Eric M, Schulz, Andrea, Shulman, Joshua M, Singleton, Andrew B, Smith, Albert V, Sutin, Angelina R, Uitterlinden, André G, Völzke, Henry, Widen, Elisabeth, Yaffe, Kristine, Zonderman, Alan B, Cucca, Francesco, Harris, Tamara, Ladwig, Karl-Heinz, Llewellyn, David J, Räikkönen, Katri, Tanaka, Toshiko, van Duijn, Cornelia M, Grabe, Hans J, Launer, Lenore J, Lunetta, Kathryn L, Mosley, Thomas H, Newman, Anne B, Tiemeier, Henning, Murabito, Joanne, Hek, Karin, Hek, Karin, Demirkan, Ayse, Lahti, Jari, Terracciano, Antonio, Teumer, Alexander, Cornelis, Marilyn C, Amin, Najaf, Bakshis, Erin, Baumert, Jens, Ding, Jingzhong, Liu, Yongmei, Marciante, Kristin, Meirelles, Osorio, Nalls, Michael A, Sun, Yan V, Vogelzangs, Nicole, Yu, Lei, Bandinelli, Stefania, Benjamin, Emelia J, Bennett, David A, Boomsma, Dorret, Cannas, Alessandra, Coker, Laura H, de Geus, Eco, De Jager, Philip L, Diez-Roux, Ana V, Purcell, Shaun, Hu, Frank B, Rimma, Eric B, Hunter, David J, Jensen, Majken K, Curhan, Gary, Rice, Kenneth, Penman, Alan D, Rotter, Jerome I, Sotoodehnia, Nona, Emeny, Rebecca, Eriksson, Johan G, Evans, Denis A, Ferrucci, Luigi, Fornage, Myriam, Gudnason, Vilmundur, Hofman, Albert, Illig, Thomas, Kardia, Sharon, Kelly-Hayes, Margaret, Koenen, Karestan, Kraft, Peter, Kuningas, Maris, Massaro, Joseph M, Melzer, David, Mulas, Antonella, Mulder, Cornelis L, Murray, Anna, Oostra, Ben A, Palotie, Aarno, Penninx, Brenda, Petersmann, Astrid, Pilling, Luke C, Psaty, Bruce, Rawal, Rajesh, Reiman, Eric M, Schulz, Andrea, Shulman, Joshua M, Singleton, Andrew B, Smith, Albert V, Sutin, Angelina R, Uitterlinden, André G, Völzke, Henry, Widen, Elisabeth, Yaffe, Kristine, Zonderman, Alan B, Cucca, Francesco, Harris, Tamara, Ladwig, Karl-Heinz, Llewellyn, David J, Räikkönen, Katri, Tanaka, Toshiko, van Duijn, Cornelia M, Grabe, Hans J, Launer, Lenore J, Lunetta, Kathryn L, Mosley, Thomas H, Newman, Anne B, Tiemeier, Henning, and Murabito, Joanne

Abstract

BackgroundDepression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms.MethodsIn this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p<1×10(-5)) was performed in five studies assessing depressive symptoms with other instruments. In addition, we performed a combined meta-analysis of all 22 discovery and replication studies.ResultsThe discovery sample comprised 34,549 individuals (mean age of 66.5) and no loci reached genome-wide significance (lowest p = 1.05×10(-7)). Seven independent single nucleotide polymorphisms were considered for replication. In the replication set (n = 16,709), we found suggestive association of one single nucleotide polymorphism with depressive symptoms (rs161645, 5q21, p = 9.19×10(-3)). This 5q21 region reached genome-wide significance (p = 4.78×10(-8)) in the overall meta-analysis combining discovery and replication studies (n = 51,258).ConclusionsThe results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms.

Published
2013

217. Gene × physical activity interactions in obesity:combined analysis of 111,421 individuals of European ancestry

Author

Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V, Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W, Chu, Audrey Y, Rose, Lynda M, Ganna, Andrea, Qi, Qibin, Stančáková, Alena, Sandholt, Camilla H, Elks, Cathy E, Curhan, Gary, Jensen, Majken K, Tamimi, Rulla M, Allin, Kristine H, Jørgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Paré, Guillaume, Magnusson, Patrik K E, Pedersen, Nancy L, Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L, Pasquale, Louis T, Pedersen, Oluf, Scott, Robert A, Ridker, Paul M, Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J, Chasman, Daniel I, Hallmans, Göran, Hu, Frank B, Renström, Frida, Orho-Melander, Marju, Franks, Paul W, Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V, Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W, Chu, Audrey Y, Rose, Lynda M, Ganna, Andrea, Qi, Qibin, Stančáková, Alena, Sandholt, Camilla H, Elks, Cathy E, Curhan, Gary, Jensen, Majken K, Tamimi, Rulla M, Allin, Kristine H, Jørgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Paré, Guillaume, Magnusson, Patrik K E, Pedersen, Nancy L, Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L, Pasquale, Louis T, Pedersen, Oluf, Scott, Robert A, Ridker, Paul M, Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J, Chasman, Daniel I, Hallmans, Göran, Hu, Frank B, Renström, Frida, Orho-Melander, Marju, and Franks, Paul W

Abstract

Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. Twelve obesity-susceptibility loci were genotyped or imputed in 111,421 participants. A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. Physical activity was assessed using self-administered questionnaires. Multiplicative interactions between the GRS and physical activity on BMI were tested in linear and logistic regression models in each cohort, with adjustment for age, age(2), sex, study center (for multicenter studies), and the marginal terms for physical activity and the GRS. These results were combined using meta-analysis weighted by cohort sample size. The meta-analysis yielded a statistically significant GRS × physical activity interaction effect estimate (Pinteraction = 0.015). However, a statistically significant interaction effect was only apparent in North American cohorts (n = 39,810, Pinteraction = 0.014 vs. n = 71,611, Pinteraction = 0.275 for Europeans). In secondary analyses, both the FTO rs1121980 (Pinteraction = 0.003) and the SEC16B rs10913469 (Pinteraction = 0.025) variants showed evidence of SNP × physical activity interactions. This meta-analysis of 111,421 individuals provides further support for an interaction between physical activity and a GRS in obesity disposition, although these findings hinge on the inclusion of cohorts from North America, indicating that these results are either population-specific or non-causal.

Published
2013

219. Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study

Author

Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken K, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby, Schunkert, Heribert, Samani, Nilesh J, Clarke, Robert, Hopewell, Jemma C, Thompson, John F, Li, Mingyao, Thorleifsson, Gudmar, Newton-Cheh, Christopher, Musunuru, Kiran, Pirruccello, James P, Saleheen, Danish, Chen, Li, Stewart, Alexandre F R, Schillert, Arne, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Anand, Sonia, Engert, James C, Morgan, Thomas, Spertus, John, Stoll, Monika, Berger, Klaus, Martinelli, Nicola, Girelli, Domenico, McKeown, Pascal P, Patterson, Christopher C, Epstein, Stephen E, Devaney, Joseph, Burnett, Mary-Susan, Mooser, Vincent, Ripatti, Samuli, Surakka, Ida, Nieminen, Markku S, Sinisalo, Juha, Lokki, Marja-Liisa, Perola, Markus, Havulinna, Aki, de Faire, Ulf, Gigante, Bruna, Ingelsson, Erik, Zeller, Tanja, Wild, Philipp, de Bakker, Paul I W, Klungel, Olaf H, Maitland-van der Zee, Anke-Hilse, Peters, Bas J M, de Boer, Anthonius, Grobbee, Diederick E, Kamphuisen, Pieter W, Deneer, Vera H M, Elbers, Clara C, Onland-Moret, N Charlotte, Hofker, Marten H, Wijmenga, Cisca, Verschuren, W M Monique, Boer, Jolanda M A, van der Schouw, Yvonne T, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, Willer, Cristen, Do, Ron, Ordovas, Jose M, Abecasis, Gonçalo R, Boehnke, Michael, Mohlke, Karen L, Daly, Mark J, Guiducci, Candace, Burtt, Noël P, Surti, Aarti, Gonzalez, Elena, Purcell, Shaun, Gabriel, Stacey, Marrugat, Jaume, Peden, John, Erdmann, Jeanette, Diemert, Patrick, Willenborg, Christina, König, Inke R, Fischer, Marcus, Hengstenberg, Christian, Ziegler, Andreas, Buysschaert, Ian, Lambrechts, Diether, Van de Werf, Frans, Fox, Keith A, El Mokhtari, Nour Eddine, Rubin, Diana, Schrezenmeir, Jürgen, Schreiber, Stefan, Schäfer, Arne, Danesh, John, Blankenberg, Stefan, Roberts, Robert, McPherson, Ruth, Watkins, Hugh, Hall, Alistair S, Overvad, Kim, Rimm, Eric, Boerwinkle, Eric, Tybjaerg-Hansen, Anne, Cupples, L Adrienne, Reilly, Muredach P, Melander, Olle, Mannucci, Pier M, Ardissino, Diego, Siscovick, David, Elosua, Roberto, Stefansson, Kari, O'Donnell, Christopher J, Salomaa, Veikko, Rader, Daniel J, Peltonen, Leena, Schwartz, Stephen M, Altshuler, David, Kathiresan, Sekar, Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken K, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby, Schunkert, Heribert, Samani, Nilesh J, Clarke, Robert, Hopewell, Jemma C, Thompson, John F, Li, Mingyao, Thorleifsson, Gudmar, Newton-Cheh, Christopher, Musunuru, Kiran, Pirruccello, James P, Saleheen, Danish, Chen, Li, Stewart, Alexandre F R, Schillert, Arne, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Anand, Sonia, Engert, James C, Morgan, Thomas, Spertus, John, Stoll, Monika, Berger, Klaus, Martinelli, Nicola, Girelli, Domenico, McKeown, Pascal P, Patterson, Christopher C, Epstein, Stephen E, Devaney, Joseph, Burnett, Mary-Susan, Mooser, Vincent, Ripatti, Samuli, Surakka, Ida, Nieminen, Markku S, Sinisalo, Juha, Lokki, Marja-Liisa, Perola, Markus, Havulinna, Aki, de Faire, Ulf, Gigante, Bruna, Ingelsson, Erik, Zeller, Tanja, Wild, Philipp, de Bakker, Paul I W, Klungel, Olaf H, Maitland-van der Zee, Anke-Hilse, Peters, Bas J M, de Boer, Anthonius, Grobbee, Diederick E, Kamphuisen, Pieter W, Deneer, Vera H M, Elbers, Clara C, Onland-Moret, N Charlotte, Hofker, Marten H, Wijmenga, Cisca, Verschuren, W M Monique, Boer, Jolanda M A, van der Schouw, Yvonne T, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, Willer, Cristen, Do, Ron, Ordovas, Jose M, Abecasis, Gonçalo R, Boehnke, Michael, Mohlke, Karen L, Daly, Mark J, Guiducci, Candace, Burtt, Noël P, Surti, Aarti, Gonzalez, Elena, Purcell, Shaun, Gabriel, Stacey, Marrugat, Jaume, Peden, John, Erdmann, Jeanette, Diemert, Patrick, Willenborg, Christina, König, Inke R, Fischer, Marcus, Hengstenberg, Christian, Ziegler, Andreas, Buysschaert, Ian, Lambrechts, Diether, Van de Werf, Frans, Fox, Keith A, El Mokhtari, Nour Eddine, Rubin, Diana, Schrezenmeir, Jürgen, Schreiber, Stefan, Schäfer, Arne, Danesh, John, Blankenberg, Stefan, Roberts, Robert, McPherson, Ruth, Watkins, Hugh, Hall, Alistair S, Overvad, Kim, Rimm, Eric, Boerwinkle, Eric, Tybjaerg-Hansen, Anne, Cupples, L Adrienne, Reilly, Muredach P, Melander, Olle, Mannucci, Pier M, Ardissino, Diego, Siscovick, David, Elosua, Roberto, Stefansson, Kari, O'Donnell, Christopher J, Salomaa, Veikko, Rader, Daniel J, Peltonen, Leena, Schwartz, Stephen M, Altshuler, David, and Kathiresan, Sekar

Abstract

BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Second, we used as an instrument a genetic score consisting of 14 common SNPs that exclusively associate with HDL cholesterol and tested this score in up to 12,482 cases of myocardial infarction and 41,331 controls. As a positive control, we also tested a genetic score of 13 common SNPs exclusively associated with LDL cholesterol. FINDINGS: Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10(-13)) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers. This difference in HDL cholesterol is expected to decrease risk of myocardial infarction by 13% (odds ratio [OR] 0·87, 95% CI 0·84-0·91). However, we noted that the 396Ser allele was not associated with risk of myocardial infarction (OR 0·99, 95% CI 0·88-1·11, p=0·85). From observational epidemiology, an increase of 1 SD in HDL cholesterol was associated with reduced risk of myocardial infarction (OR 0·62, 95% CI 0·58-0·66). However, a 1 SD increase in HDL cholesterol due to genetic score was not associated with risk of myocardial infarction (OR 0·93, 95% CI 0·68-1·26, p=0·63). For LDL cholesterol, the estimate from observational epidemiology (a 1 SD increase in LDL cholesterol associated with OR 1·54, 95% CI 1·45-1·63) wa

Published
2012
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220. The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations

Author

Vogel, Ulla Birgitte, Jensen, Majken K., Due, Karen Margrete, Rimm, Eric B., Wallin, Håkan, Nielsen, Michael R.S., Pedersen, Anne-Pernille T., Tjønneland, Anne, Overvad, Kim, Vogel, Ulla Birgitte, Jensen, Majken K., Due, Karen Margrete, Rimm, Eric B., Wallin, Håkan, Nielsen, Michael R.S., Pedersen, Anne-Pernille T., Tjønneland, Anne, and Overvad, Kim

Abstract

AimInflammation is a risk factor for coronary heart disease (CHD). A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects. We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women. Methods and resultsThe NFKB1 ins/del polymorphism was genotyped in studies of CHD nested within the Diet, Cancer and Health (DCH) study, the Health Professionals Follow-up (HPFS) and the Nurses’ Health (NHS) studies, totaling 1008, 428 and 439 cases, respectively. The minor allele frequency in the combined sample was 0.38 among controls. In a pooled analysis, the relative risk (RR) among heterozygous men and women was 1.22 (95% CI: 1.07–1.40), compared to the most common ins/ins genotype. The RR among homozygotes was 1.20 (95% CI: 0.94–1.53). There was no evidence of an allele-dosage effect, and in a dominant model the RR among del-allele carriers was 1.22 (95% CI: 1.07–1.39). The risk was similar in women and men (RR was 1.20 in women and 1.23 in men, respectively). The NFKB1 variant was not associated with plasma lipid levels, but del-carriers had lower levels of C-reactive protein. ConclusionsThe NFKB1 promoter variant, previously shown to cause partial depletion of NF-κB p50, was associated with a higher risk of CHD in three independent prospective studies of generally healthy Caucasians.

Published
2011

221. Protein interaction-based genome-wide analysis of incident coronary heart disease

Author

Jensen, Majken K, Pers, Tune H, Dworzynski, Piotr, Girman, Cynthia J, Brunak, Søren, Rimm, Eric B, Jensen, Majken K, Pers, Tune H, Dworzynski, Piotr, Girman, Cynthia J, Brunak, Søren, and Rimm, Eric B

Abstract

Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD).

Published
2011

223. Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

Author

University of Helsinki, Hjelt Institute, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health, Saccone, Nancy L., Culverhouse, Robert C., Schwantes-An, Tae-Hwi, Cannon, Dale S., Chen, Xiangning, Cichon, Sven, Giegling, Ina, Han, Shizhong, Han, Younghun, Keskitalo-Vuokko, Kaisu, Kong, Xiangyang, Landi, Maria Teresa, Ma, Jennie Z., Short, Susan E., Stephens, Sarah H., Stevens, Victoria L., Sun, Lingwei, Wang, Yufei, Wenzlaff, Angela S., Aggen, Steven H., Breslau, Naomi, Broderick, Peter, Chatterjee, Nilanjan, Chen, Jingchun, Heath, Andrew C., Heliovaara, Markku, Hoft, Nicole R., Hunter, David J., Jensen, Majken K., Martin, Nicholas G., Montgomery, Grant W., Niu, Tianhua, Payne, Thomas J., Palotie, Leena, Pergadia, Michele L., Rice, John P., Sherva, Richard, Spitz, Margaret R., Sun, Juzhong, Wang, Jen C., Weiss, Robert B., Wheeler, William, Witt, Stephanie H., Yang, Bao-Zhu, Caporaso, Neil E., Ehringer, Marissa A., Eisen, Tim, Gapstur, Susan M., Gelernter, Joel, Houlston, Richard, Kaprio, Jaakko, Kendler, Kenneth S., Kraft, Peter, Leppert, Mark F., Li, Ming D., Madden, Pamela A. F., Noethen, Markus M., Pillai, Sreekumar, Rietschel, Marcella, Rujescu, Dan, Schwartz, Ann, Amos, Christopher I., Bierut, Laura J., University of Helsinki, Hjelt Institute, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health, Saccone, Nancy L., Culverhouse, Robert C., Schwantes-An, Tae-Hwi, Cannon, Dale S., Chen, Xiangning, Cichon, Sven, Giegling, Ina, Han, Shizhong, Han, Younghun, Keskitalo-Vuokko, Kaisu, Kong, Xiangyang, Landi, Maria Teresa, Ma, Jennie Z., Short, Susan E., Stephens, Sarah H., Stevens, Victoria L., Sun, Lingwei, Wang, Yufei, Wenzlaff, Angela S., Aggen, Steven H., Breslau, Naomi, Broderick, Peter, Chatterjee, Nilanjan, Chen, Jingchun, Heath, Andrew C., Heliovaara, Markku, Hoft, Nicole R., Hunter, David J., Jensen, Majken K., Martin, Nicholas G., Montgomery, Grant W., Niu, Tianhua, Payne, Thomas J., Palotie, Leena, Pergadia, Michele L., Rice, John P., Sherva, Richard, Spitz, Margaret R., Sun, Juzhong, Wang, Jen C., Weiss, Robert B., Wheeler, William, Witt, Stephanie H., Yang, Bao-Zhu, Caporaso, Neil E., Ehringer, Marissa A., Eisen, Tim, Gapstur, Susan M., Gelernter, Joel, Houlston, Richard, Kaprio, Jaakko, Kendler, Kenneth S., Kraft, Peter, Leppert, Mark F., Li, Ming D., Madden, Pamela A. F., Noethen, Markus M., Pillai, Sreekumar, Rietschel, Marcella, Rujescu, Dan, Schwartz, Ann, Amos, Christopher I., and Bierut, Laura J.

Published
2010

224. A prospective analysis of the association between dietary fiber intake and prostate cancer risk in EPIC.

Author

Suzuki, Reiko, Allen, Naomi E, Key, Timothy J, Appleby, Paul N, Tjønneland, Anne, Johnsen, Nina Føns, Jensen, Majken K, Overvad, Kim, Boeing, Heiner, Pischon, Tobias, Kaaks, Rudolf, Rohrmann, Sabine, Trichopoulou, Antonia, Misirli, Gesthimani, Trichopoulos, Dimitrios, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel, Sacerdote, Carlotta, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Ardanaz, Eva, Quirós, José Ramón, Larrañaga, Nerea, Sánchez, Maria-José, Tormo, María-José, Jakszyn, Paula, Johansson, Ingegerd, Stattin, Pär, Berglund, Göran, Manjer, Jonas, Bingham, Sheila, Khaw, Kay-Tee, Egevad, Lars, Ferrari, Pietro, Jenab, Mazda, Riboli, Elio, Suzuki, Reiko, Allen, Naomi E, Key, Timothy J, Appleby, Paul N, Tjønneland, Anne, Johnsen, Nina Føns, Jensen, Majken K, Overvad, Kim, Boeing, Heiner, Pischon, Tobias, Kaaks, Rudolf, Rohrmann, Sabine, Trichopoulou, Antonia, Misirli, Gesthimani, Trichopoulos, Dimitrios, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel, Sacerdote, Carlotta, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Ardanaz, Eva, Quirós, José Ramón, Larrañaga, Nerea, Sánchez, Maria-José, Tormo, María-José, Jakszyn, Paula, Johansson, Ingegerd, Stattin, Pär, Berglund, Göran, Manjer, Jonas, Bingham, Sheila, Khaw, Kay-Tee, Egevad, Lars, Ferrari, Pietro, Jenab, Mazda, and Riboli, Elio

Abstract

Few studies have examined the association between dietary fiber intake and prostate cancer risk. We evaluated the association between dietary fiber intake and the risk of prostate cancer among 142,590 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Consumption of dietary fiber (total, cereal, fruit and vegetable fiber) was estimated by validated dietary questionnaires and calibrated using 24-hr dietary recalls. Incidence rate ratios were estimated using Cox regression and adjusted for potential confounding factors. During an average of 8.7 years follow-up, prostate cancer was diagnosed in 2,747 men. Overall, there was no association between dietary fiber intake (total, cereal, fruit or vegetable fiber) and prostate cancer risk, although calibrated intakes of total fiber and fruit fiber were associated with nonstatistically significant reductions in risk. There was no association between fiber derived from cereals or vegetables and risk and no evidence for heterogeneity in any of the risk estimates by stage or grade of disease. Our results suggest that dietary fiber intake is not associated with prostate cancer risk.

Published
2009
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225. S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies

Author

Jensen, Majken K, Rimm, Eric B, Rader, Daniel, Schmidt, Erik B, Sørensen, Thorkild I A, Vogel, Ulla, Overvad, Kim, Mukamal, Kenneth J, Jensen, Majken K, Rimm, Eric B, Rader, Daniel, Schmidt, Erik B, Sørensen, Thorkild I A, Vogel, Ulla, Overvad, Kim, and Mukamal, Kenneth J

Abstract

Udgivelsesdato: 2009-Feb, BACKGROUND: Lipoprotein lipase (LPL) has a prominent role in the metabolism of triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) and is a potential interesting target for the development of antiatherogenic treatment. To provide deeper insight into the role of natural variation in this gene, we investigated the association between the LPL S447X variant with lipids and risk of coronary heart disease (CHD) in 3 independent, prospective studies. METHODS: The S447X variant was genotyped in case-control studies of incident CHD nested within the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Danish Diet, Cancer and Health (DCH) study, totaling 245, 258, and 962 cases, respectively. RESULTS: S447X carriers tended to have lower TG and higher HDL-C concentrations than noncarriers. The S447X variant was associated with a lower risk of CHD in the NHS; the association was weaker in the HPFS and not statistically significant in the DCH women and men. The pooled relative risk per minor allele was 0.74 (0.56-1.00). There was a suggestion that the associations of the S447X variant with plasma lipids and CHD risk were more pronounced in obese individuals in the NHS study, but this finding was not consistent across the studies. CONCLUSIONS: The LPL S447X variant tended to be associated with lower TG and higher HDL-C levels, and lower risk of CHD in all 3 cohorts. Lipoprotein lipase is an attractive target for clinical intervention, but studies are needed to clarify whether greater benefit from this variant may be conferred in some subgroups.

Published
2009

226. The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

Author

Jensen, Majken K, Rimm, Eric B, Mukamal, Kenneth J, Edmondson, Andrew C, Rader, Daniel J, Vogel, Ulla, Tjønneland, Anne, Sørensen, Thorkild I A, Schmidt, Erik B, Overvad, Kim, Jensen, Majken K, Rimm, Eric B, Mukamal, Kenneth J, Edmondson, Andrew C, Rader, Daniel J, Vogel, Ulla, Tjønneland, Anne, Sørensen, Thorkild I A, Schmidt, Erik B, and Overvad, Kim

Abstract

Udgivelsesdato: 2009-Jul, AIMS: Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS: The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele. CONCLUSION: Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.

Published
2009

227. PPAR gamma Pro(12)Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes

Author

Vogel, Ulla Birgitte, Segel, Stine, Dethlefsen, Claus, Tjønneland, Anne, Thoustrup Saber, Anne, Wallin, Håkan, Jensen, Majken K., Schmidt, Erik B, Skytt Andersen, Paal, Overvad, Kim, Vogel, Ulla Birgitte, Segel, Stine, Dethlefsen, Claus, Tjønneland, Anne, Thoustrup Saber, Anne, Wallin, Håkan, Jensen, Majken K., Schmidt, Erik B, Skytt Andersen, Paal, and Overvad, Kim

Abstract

Background: Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the western world. Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays a key role in the regulation of the energy balance, adipocyte differentiation and lipid biosynthesis. The aim was to investigate if the polymorphism PPAR gamma 2 Pro(12)Ala, which encodes a less efficient transcription factor, was associated with risk of acute coronary disease and if there were interactions between this polymorphism and factors that modify PPAR gamma activity, such as alcohol intake, smoking, and use of non-steroidal anti-inflammatory medicine. Methods: A case-cohort study including 1031 ACS cases and a sub-cohort of 1703 persons was nested within the population-based prospective study Diet, Cancer and Health of 57,053 individuals. Results: Homozygous male variant allele carriers of PPAR gamma 2 Pro(12)Ala were at higher risk of ACS (HR = 2.12, 95% CI: 1.00-4.48) than homozygous carriers of the Pro-allele. Among men, there was a statistically significant interaction between genotypes and alcohol intake such that homozygous variant allele carriers with a low alcohol intake were at higher risk of ACS (HR = 25.3, CI: 16.5-38.7) compared to homozygous common allele carriers (p for interaction <0.0001). Overall, the association was only observed among homozygous variant allele carriers. Thus, all the observed associations were obtained in subgroups including small numbers of cases. It is therefore possible that the observed associations were due to chance. Conclusion: In the present study, there were no consistent associations between PPAR gamma Pro(12)Ala and risk of ACS, and no consistent interaction with alcohol, BMI, NSAID or smoking in relation to ACS.

Published
2009

228. Associations between Alcohol Consumption and HDL Subspecies Defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study.

Author

Wilkens, Trine L., Sørensen, Helle, Jensen, Majken K., Furtado, Jeremy D., Dragsted, Lars O., and Mukamal, Kenneth J.

Abstract

Alcohol consumption increases circulating high-density lipoprotein cholesterol (HDL-C), but HDL protein cargo may better reflect HDL function. This study examined the associations between alcohol intake and HDL subspecies containing or lacking apoC3, apoE, and apoJ in a well-phenotyped cohort. We performed a cross-sectional analysis of 2092 Cardiovascular Health Study participants aged 70 or older with HDL subspecies measured in stored specimens from 1998 to 1999. Associations between alcohol intake and apoA1 defined HDL subspecies lacking or containing apoC3, apoE, and apoJ, and circulating levels of total apoA1, apoC3, apoE, and apoJ were examined. HDL subspecies lacking and containing apoC3, apoE, and apoJ were all positively associated with alcohol intake, with ∼1% per additional drink per week or ∼7% per additional drink per day (subspecies without the apolipoproteins, P ≤ 2 × 10-9, subspecies with the apolipoproteins, P ≤ 3 × 10-5). Total apoA1 was also directly associated with alcohol consumption, with a 1% increase per additional drink per week (P = 1 × 10-14). Total apoC3 blood levels were 0.5% higher per additional drink per week (P = 0.01), but the association was driven by a few heavily drinking men. Alcohol intake was positively associated with HDL subspecies lacking and containing apoC3, apoE, or apoJ, and with total plasma apoA1. ApoC3 was directly, albeit not as robustly associated with alcohol intake. HDL protein cargo is crucial for its anti-atherosclerotic functions, but it remains to be determined whether HDL subspecies play a role in the putative association between limited alcohol intake and lower risk of coronary heart disease. [ABSTRACT FROM AUTHOR]

Published
2023
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229. Alcohol consumption and the risk for prostate cancer in the European prospective investigation into cancer and nutrition.

Author

Rohrmann, Sabine, Linseisen, Jakob, Key, Timothy J, Jensen, Majken K, Overvad, Kim, Johnsen, Nina Føns, Tjønneland, Anne, Kaaks, Rudolf, Bergmann, Manuela M, Weikert, Cornelia, Naska, Androniki, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Pala, Valeria, Sacerdote, Carlotta, Palli, Domenico, Tumino, Rosario, Bueno-de-Mesquita, H Bas, Vrieling, Alina, González, Carlos A, Larrañaga, Nerea, Navarro, Carmen, Barricarte, Aurelio, Quiros, J Ramon, Martínez-García, Carmen, Hallmans, Göran, Stattin, Pär, Manjer, Jonas, Wirfält, Elisabet, Bingham, Sheila, Khaw, Key-Tee, Egevad, Lars, Ferrari, Pietro, Jenab, Mazda, Riboli, Elio, Rohrmann, Sabine, Linseisen, Jakob, Key, Timothy J, Jensen, Majken K, Overvad, Kim, Johnsen, Nina Føns, Tjønneland, Anne, Kaaks, Rudolf, Bergmann, Manuela M, Weikert, Cornelia, Naska, Androniki, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Pala, Valeria, Sacerdote, Carlotta, Palli, Domenico, Tumino, Rosario, Bueno-de-Mesquita, H Bas, Vrieling, Alina, González, Carlos A, Larrañaga, Nerea, Navarro, Carmen, Barricarte, Aurelio, Quiros, J Ramon, Martínez-García, Carmen, Hallmans, Göran, Stattin, Pär, Manjer, Jonas, Wirfält, Elisabet, Bingham, Sheila, Khaw, Key-Tee, Egevad, Lars, Ferrari, Pietro, Jenab, Mazda, and Riboli, Elio

Published
2008

230. CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

Author

Jenab, Mazda, McKay, James D, Ferrari, Pietro, Biessy, Carine, Laing, Stewart, Munar, Gabriel Maria Capella, Sala, Núria, Peña, Salvador, Crusius, J B A, Overvad, Kim, Jensen, Majken K, Olsen, Anja, Tjonneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Bergmann, Manuela M, Trichopoulou, Antonia, Georgila, Christina, Psaltopoulou, Theodora, Mattiello, Amalia, Vineis, Paolo, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Numans, Mattijs E, Peeters, Petra H M, Bueno-de-Mesquita, H Bas, Lund, Eiliv, Ardanaz, Eva, Sánchez, Maria-Jose, Dorronsoro, Miren, Sanchez, Carmen Navarro, Quirós, José Ramón, Hallmans, Göran, Stenling, Roger, Manjer, Jonas, Régner, Sara, Key, Tim, Bingham, Sheila, Khaw, Kay-tee, Slimani, Nadia, Rinaldi, Sabina, Boffetta, Paolo, Carneiro, Fátima, Riboli, Elio, Gonzalez, Carlos, Jenab, Mazda, McKay, James D, Ferrari, Pietro, Biessy, Carine, Laing, Stewart, Munar, Gabriel Maria Capella, Sala, Núria, Peña, Salvador, Crusius, J B A, Overvad, Kim, Jensen, Majken K, Olsen, Anja, Tjonneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Bergmann, Manuela M, Trichopoulou, Antonia, Georgila, Christina, Psaltopoulou, Theodora, Mattiello, Amalia, Vineis, Paolo, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Numans, Mattijs E, Peeters, Petra H M, Bueno-de-Mesquita, H Bas, Lund, Eiliv, Ardanaz, Eva, Sánchez, Maria-Jose, Dorronsoro, Miren, Sanchez, Carmen Navarro, Quirós, José Ramón, Hallmans, Göran, Stenling, Roger, Manjer, Jonas, Régner, Sara, Key, Tim, Bingham, Sheila, Khaw, Kay-tee, Slimani, Nadia, Rinaldi, Sabina, Boffetta, Paolo, Carneiro, Fátima, Riboli, Elio, and Gonzalez, Carlos

Published
2008

233. Common FABP4 Genetic Variants and Plasma Levels of Fatty Acid Binding Protein 4 in Older Adults

Author

Mukamal, Kenneth J., primary, Wilk, Jemma B., additional, Biggs, Mary L., additional, Jensen, Majken K., additional, Ix, Joachim H., additional, Kizer, Jorge R., additional, Tracy, Russell P., additional, Zieman, Susan J., additional, Mozaffarian, Dariush, additional, Psaty, Bruce M., additional, Siscovick, David S., additional, and Djoussé, Luc, additional

Published
2013
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236. Interaction between Obesity and the NFKB1 - 94ins/delATTG Promoter Polymorphism in Relation to Incident Acute Coronary Syndrome: A Follow Up Study in Three Independent Cohorts

Author

Stegger, Jakob Gerhard, primary, Schmidt, Erik Berg, additional, Berentzen, Tina Landsvig, additional, Tjønneland, Anne, additional, Vogel, Ulla, additional, Rimm, Eric, additional, Sørensen, Thorkild I. A., additional, Overvad, Kim, additional, and Jensen, Majken K., additional

Published
2013
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237. A Genome-Wide Association Study of Depressive Symptoms

Author

Hek, Karin, primary, Demirkan, Ayse, additional, Lahti, Jari, additional, Terracciano, Antonio, additional, Teumer, Alexander, additional, Cornelis, Marilyn C., additional, Amin, Najaf, additional, Bakshis, Erin, additional, Baumert, Jens, additional, Ding, Jingzhong, additional, Liu, Yongmei, additional, Marciante, Kristin, additional, Meirelles, Osorio, additional, Nalls, Michael A., additional, Sun, Yan V., additional, Vogelzangs, Nicole, additional, Yu, Lei, additional, Bandinelli, Stefania, additional, Benjamin, Emelia J., additional, Bennett, David A., additional, Boomsma, Dorret, additional, Cannas, Alessandra, additional, Coker, Laura H., additional, de Geus, Eco, additional, De Jager, Philip L., additional, Diez-Roux, Ana V., additional, Purcell, Shaun, additional, Hu, Frank B., additional, Rimm, Eric B., additional, Hunter, David J., additional, Jensen, Majken K., additional, Curhan, Gary, additional, Rice, Kenneth, additional, Penman, Alan D., additional, Rotter, Jerome I., additional, Sotoodehnia, Nona, additional, Emeny, Rebecca, additional, Eriksson, Johan G., additional, Evans, Denis A., additional, Ferrucci, Luigi, additional, Fornage, Myriam, additional, Gudnason, Vilmundur, additional, Hofman, Albert, additional, Illig, Thomas, additional, Kardia, Sharon, additional, Kelly-Hayes, Margaret, additional, Koenen, Karestan, additional, Kraft, Peter, additional, Kuningas, Maris, additional, Massaro, Joseph M., additional, Melzer, David, additional, Mulas, Antonella, additional, Mulder, Cornelis L., additional, Murray, Anna, additional, Oostra, Ben A., additional, Palotie, Aarno, additional, Penninx, Brenda, additional, Petersmann, Astrid, additional, Pilling, Luke C., additional, Psaty, Bruce, additional, Rawal, Rajesh, additional, Reiman, Eric M., additional, Schulz, Andrea, additional, Shulman, Joshua M., additional, Singleton, Andrew B., additional, Smith, Albert V., additional, Sutin, Angelina R., additional, Uitterlinden, André G., additional, Völzke, Henry, additional, Widen, Elisabeth, additional, Yaffe, Kristine, additional, Zonderman, Alan B., additional, Cucca, Francesco, additional, Harris, Tamara, additional, Ladwig, Karl-Heinz, additional, Llewellyn, David J., additional, Räikkönen, Katri, additional, Tanaka, Toshiko, additional, van Duijn, Cornelia M., additional, Grabe, Hans J., additional, Launer, Lenore J., additional, Lunetta, Kathryn L., additional, Mosley, Thomas H., additional, Newman, Anne B., additional, Tiemeier, Henning, additional, and Murabito, Joanne, additional

Published
2013
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238. Sugar-Sweetened Beverages and Genetic Risk of Obesity

Author

Qi, Qibin, primary, Chu, Audrey Y., additional, Kang, Jae H., additional, Jensen, Majken K., additional, Curhan, Gary C., additional, Pasquale, Louis R., additional, Ridker, Paul M., additional, Hunter, David J., additional, Willett, Walter C., additional, Rimm, Eric B., additional, Chasman, Daniel I., additional, Hu, Frank B., additional, and Qi, Lu, additional

Published
2013
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239. Haptoglobin Genotype Is a Consistent Marker of Coronary Heart Disease Risk Among Individuals With Elevated Glycosylated Hemoglobin

Author

Cahill, Leah E., primary, Levy, Andrew P., additional, Chiuve, Stephanie E., additional, Jensen, Majken K., additional, Wang, Hong, additional, Shara, Nawar M., additional, Blum, Shany, additional, Howard, Barbara V., additional, Pai, Jennifer K., additional, Mukamal, Kenneth J., additional, Rexrode, Kathryn M., additional, and Rimm, Eric B., additional

Published
2013
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240. Haplotype-Based Analysis of Common Variation in the Acetyl-CoA Carboxylase {alpha} Gene and Breast Cancer Risk: A Case-Control Study Nested within the European Prospective Investigation into Cancer and Nutrition.

Author

Sinilnikova, Olga M, McKay, James D, Tavtigian, Sean V, Canzian, Federico, Desilva, Deepika, Biessy, Carine, Monnier, Stéphanie, Dossus, Laure, Boillot, Catherine, Gioia, Lydie, Hughes, David J, Jensen, Majken K, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Clavel-Chapelon, Francoise, Chajès, Véronique, Joulin, Virginie, Linseisen, Jakob, Chang-Claude, Jenny, Boeing, Heiner, Dahm, Stephan, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Koliva, Maria, Khaw, Kay-Tee, Bingham, Sheila, Allen, Naomi E, Key, Timothy, Palli, Domenico, Panico, Salvatore, Berrino, Franco, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Peeters, Petra H, van Gils, Carla H, Lund, Eiliv, Pera, Guillem, Quiros, José Ramón, Dorronsoro, Miren, Martinez Garcia, Carmen, Tormo, Maria-José, Ardanaz, Eva, Hallmans, Göran, Lenner, Per, Berglund, Göran, Manjer, Jonas, Riboli, Elio, Lenoir, Gilbert M, Kaaks, Rudolf, Sinilnikova, Olga M, McKay, James D, Tavtigian, Sean V, Canzian, Federico, Desilva, Deepika, Biessy, Carine, Monnier, Stéphanie, Dossus, Laure, Boillot, Catherine, Gioia, Lydie, Hughes, David J, Jensen, Majken K, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Clavel-Chapelon, Francoise, Chajès, Véronique, Joulin, Virginie, Linseisen, Jakob, Chang-Claude, Jenny, Boeing, Heiner, Dahm, Stephan, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Koliva, Maria, Khaw, Kay-Tee, Bingham, Sheila, Allen, Naomi E, Key, Timothy, Palli, Domenico, Panico, Salvatore, Berrino, Franco, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Peeters, Petra H, van Gils, Carla H, Lund, Eiliv, Pera, Guillem, Quiros, José Ramón, Dorronsoro, Miren, Martinez Garcia, Carmen, Tormo, Maria-José, Ardanaz, Eva, Hallmans, Göran, Lenner, Per, Berglund, Göran, Manjer, Jonas, Riboli, Elio, Lenoir, Gilbert M, and Kaaks, Rudolf

Published
2007

241. Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.

Author

Dehghan, Abbas, Bis, Joshua C., White, Charles C., Smith, Albert Vernon, Morrison, Alanna C., Cupples, L. Adrienne, Trompet, Stella, Chasman, Daniel I., Lumley, Thomas, Völker, Uwe, Buckley, Brendan M., Ding, Jingzhong, Jensen, Majken K., Folsom, Aaron R., Kritchevsky, Stephen B., Girman, Cynthia J., Ford, Ian, Dörr, Marcus, Salomaa, Veikko, and Uitterlinden, André G.

Subjects
MYOCARDIAL infarction, CORONARY disease, COHORT analysis, HUMAN genetic variation, LONGITUDINAL method, SINGLE nucleotide polymorphisms, PATIENTS
Abstract

Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods: We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10−6 in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with total mortality in individuals who experienced MI during follow-up. Results: In Stage I 15 loci passed the threshold of 5×10−6; 8 loci for MI and 8 loci for CHD, for which one locus overlapped and none were reported in previous GWAS meta-analyses. We took 60 SNPs representing these 15 loci to Stage II of discovery. Four SNPs near QKI showed nominally significant association with MI (p-value<8.8×10−3) and three exceeded the genome-wide significance threshold when Stage I and Stage II results were combined (top SNP rs6941513: p = 6.2×10−9). Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08). Among an inception cohort of those who experienced MI during follow-up, the risk allele of rs1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2×10−3). Conclusions: QKI represents a novel locus that may serve as a predictor of incident CHD in prospective studies. The association of the 9p21 locus both with increased risk of first myocardial infarction and longer survival after MI highlights the importance of study design in investigating genetic determinants of complex disorders. [ABSTRACT FROM AUTHOR]

Published
2016
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242. Associations of insulin resistance, inflammation and liver synthetic function with very low-density lipoprotein: The Cardiovascular Health Study.

Author

Jiang, Z. Gordon, de Boer, Ian H., Mackey, Rachel H., Jensen, Majken K., Lai, Michelle, Robson, Simon C., Tracy, Russell, Kuller, Lewis H., and Mukamal, Kenneth J.

Subjects
INSULIN resistance, LOW density lipoproteins, FATTY liver, METABOLIC syndrome, BIOMARKERS, STANDARD deviations, DIAGNOSIS
Abstract

Introduction Production of very low-density lipoprotein (VLDL) is increased in states of metabolic syndrome, leading to hypertriglyceridemia. However, metabolic syndrome is often associated with non-alcoholic fatty liver disease, which leads to liver fibrosis and inflammation that may decrease VLDL production. In this study, we aim to determine the interactive impact on VLDL profiles from insulin resistance, impairment in liver synthetic function and inflammation. Methods We examined cross-sectional associations of insulin sensitivity, inflammation, and liver synthetic function with VLDL particle (VLDL-P) concentration and size among 1,850 older adults in the Cardiovascular Health Study. Results Indices for high insulin sensitivity and low liver synthetic function were associated with lower concentrations of VLDL-P. In addition, insulin resistance preferentially increased concentration of large VLDL and was associated with mean VLDL size. Indices for inflammation however demonstrated a nonlinear relationship with both VLDL-P concentration and VLDL size. When mutually adjusted, one standard deviation (SD) increment in Matsuda index and C-reactive protein (CRP) were associated with 4.9 nmol/L (− 8.2 to − 1.5, p = 0.005) and 6.3 nmol/L (− 11.0 to − 1.6, p = 0.009) lower VLDL-P concentration respectively. In contrast, one-SD increment in factor VII, a marker for liver synthetic function, was associated with 16.9 nmol/L (12.6–21.2, p < 0.001) higher VLDL-P concentration. Furthermore, a one-SD increment in the Matsuda index was associated with 1.1 nm (− 2.0 to − 0.3, p = 0.006) smaller mean VLDL size, whereas CRP and factor VII were not associated with VLDL size. Conclusion Insulin sensitivity, inflammation and markers for liver synthetic function differentially impact VLDL-P concentration and VLDL size. These results underscore the complex effects of insulin resistance and its complications on VLDL production. [ABSTRACT FROM AUTHOR]

Published
2016
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244. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

Author

Gonzalez, Carlos A, Pera, Guillem, Agudo, Antonio, Bueno-de-Mesquita, H Bas, Ceroti, Marco, Boeing, Heiner, Schulz, Mandy, Del Giudice, Giuseppe, Plebani, Mario, Carneiro, Fátima, Berrino, Franco, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simane, Henrik, Hallmans, Göran, Stenling, Roger, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quiros, José R, Allen, Naomi, Key, Timothy J, Bingham, Sheila, Day, Nicholas E, Linseisen, Jakob, Nagel, Gabriele, Overvad, Kim, Jensen, Majken K, Olsen, Anja, Tjänneland, Anne, Bächner, Frederike L, Peeters, Petra H M, Numans, Mattijs E, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Roukos, Dimitrios, Trichopoulou, Antonia, Psaltopoulou, Theodora, Lund, Eiliv, Casagrande, Corinne, Slimani, Nadia, Jenab, Mazda, Riboli, Elio, Gonzalez, Carlos A, Pera, Guillem, Agudo, Antonio, Bueno-de-Mesquita, H Bas, Ceroti, Marco, Boeing, Heiner, Schulz, Mandy, Del Giudice, Giuseppe, Plebani, Mario, Carneiro, Fátima, Berrino, Franco, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simane, Henrik, Hallmans, Göran, Stenling, Roger, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quiros, José R, Allen, Naomi, Key, Timothy J, Bingham, Sheila, Day, Nicholas E, Linseisen, Jakob, Nagel, Gabriele, Overvad, Kim, Jensen, Majken K, Olsen, Anja, Tjänneland, Anne, Bächner, Frederike L, Peeters, Petra H M, Numans, Mattijs E, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Roukos, Dimitrios, Trichopoulou, Antonia, Psaltopoulou, Theodora, Lund, Eiliv, Casagrande, Corinne, Slimani, Nadia, Jenab, Mazda, and Riboli, Elio

Published
2006

245. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).

Author

González, Carlos A, Jakszyn, Paula, Pera, Guillem, Agudo, Antonio, Bingham, Sheila, Palli, Domenico, Ferrari, Pietro, Boeing, Heiner, del Giudice, Giuseppe, Plebani, Mario, Carneiro, Fátima, Nesi, Gabriella, Berrino, Franco, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Nyrén, Olof, Hallmans, Göran, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R, Allen, Naomi, Key, Timothy J, Day, Nicholas E, Linseisen, Jakob, Nagel, Gabriele, Bergmann, Manuela M, Overvad, Kim, Jensen, Majken K, Tjonneland, Anne, Olsen, Anja, Bueno-de-Mesquita, H Bas, Ocke, Marga, Peeters, Petra H M, Numans, Mattijs E, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Psaltopoulou, Theodora, Roukos, Dimitrios, Lund, Eiliv, Hemon, Bertrand, Kaaks, Rudolf, Norat, Teresa, Riboli, Elio, González, Carlos A, Jakszyn, Paula, Pera, Guillem, Agudo, Antonio, Bingham, Sheila, Palli, Domenico, Ferrari, Pietro, Boeing, Heiner, del Giudice, Giuseppe, Plebani, Mario, Carneiro, Fátima, Nesi, Gabriella, Berrino, Franco, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Nyrén, Olof, Hallmans, Göran, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R, Allen, Naomi, Key, Timothy J, Day, Nicholas E, Linseisen, Jakob, Nagel, Gabriele, Bergmann, Manuela M, Overvad, Kim, Jensen, Majken K, Tjonneland, Anne, Olsen, Anja, Bueno-de-Mesquita, H Bas, Ocke, Marga, Peeters, Petra H M, Numans, Mattijs E, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Psaltopoulou, Theodora, Roukos, Dimitrios, Lund, Eiliv, Hemon, Bertrand, Kaaks, Rudolf, Norat, Teresa, and Riboli, Elio

Published
2006

246. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Author

Voight, Benjamin F, primary, Peloso, Gina M, additional, Orho-Melander, Marju, additional, Frikke-Schmidt, Ruth, additional, Barbalic, Maja, additional, Jensen, Majken K, additional, Hindy, George, additional, Hólm, Hilma, additional, Ding, Eric L, additional, Johnson, Toby, additional, Schunkert, Heribert, additional, Samani, Nilesh J, additional, Clarke, Robert, additional, Hopewell, Jemma C, additional, Thompson, John F, additional, Li, Mingyao, additional, Thorleifsson, Gudmar, additional, Newton-Cheh, Christopher, additional, Musunuru, Kiran, additional, Pirruccello, James P, additional, Saleheen, Danish, additional, Chen, Li, additional, Stewart, Alexandre FR, additional, Schillert, Arne, additional, Thorsteinsdottir, Unnur, additional, Thorgeirsson, Gudmundur, additional, Anand, Sonia, additional, Engert, James C, additional, Morgan, Thomas, additional, Spertus, John, additional, Stoll, Monika, additional, Berger, Klaus, additional, Martinelli, Nicola, additional, Girelli, Domenico, additional, McKeown, Pascal P, additional, Patterson, Christopher C, additional, Epstein, Stephen E, additional, Devaney, Joseph, additional, Burnett, Mary-Susan, additional, Mooser, Vincent, additional, Ripatti, Samuli, additional, Surakka, Ida, additional, Nieminen, Markku S, additional, Sinisalo, Juha, additional, Lokki, Marja-Liisa, additional, Perola, Markus, additional, Havulinna, Aki, additional, de Faire, Ulf, additional, Gigante, Bruna, additional, Ingelsson, Erik, additional, Zeller, Tanja, additional, Wild, Philipp, additional, de Bakker, Paul I W, additional, Klungel, Olaf H, additional, Maitland-van der Zee, Anke-Hilse, additional, Peters, Bas J M, additional, de Boer, Anthonius, additional, Grobbee, Diederick E, additional, Kamphuisen, Pieter W, additional, Deneer, Vera H M, additional, Elbers, Clara C, additional, Onland-Moret, N Charlotte, additional, Hofker, Marten H, additional, Wijmenga, Cisca, additional, Verschuren, WM Monique, additional, Boer, Jolanda MA, additional, van der Schouw, Yvonne T, additional, Rasheed, Asif, additional, Frossard, Philippe, additional, Demissie, Serkalem, additional, Willer, Cristen, additional, Do, Ron, additional, Ordovas, Jose M, additional, Abecasis, Gonçalo R, additional, Boehnke, Michael, additional, Mohlke, Karen L, additional, Daly, Mark J, additional, Guiducci, Candace, additional, Burtt, Noël P, additional, Surti, Aarti, additional, Gonzalez, Elena, additional, Purcell, Shaun, additional, Gabriel, Stacey, additional, Marrugat, Jaume, additional, Peden, John, additional, Erdmann, Jeanette, additional, Diemert, Patrick, additional, Willenborg, Christina, additional, König, Inke R, additional, Fischer, Marcus, additional, Hengstenberg, Christian, additional, Ziegler, Andreas, additional, Buysschaert, Ian, additional, Lambrechts, Diether, additional, Van de Werf, Frans, additional, Fox, Keith A, additional, El Mokhtari, Nour Eddine, additional, Rubin, Diana, additional, Schrezenmeir, Jürgen, additional, Schreiber, Stefan, additional, Schäfer, Arne, additional, Danesh, John, additional, Blankenberg, Stefan, additional, Roberts, Robert, additional, McPherson, Ruth, additional, Watkins, Hugh, additional, Hall, Alistair S, additional, Overvad, Kim, additional, Rimm, Eric, additional, Boerwinkle, Eric, additional, Tybjaerg-Hansen, Anne, additional, Cupples, L Adrienne, additional, Reilly, Muredach P, additional, Melander, Olle, additional, Mannucci, Pier M, additional, Ardissino, Diego, additional, Siscovick, David, additional, Elosua, Roberto, additional, Stefansson, Kari, additional, O'Donnell, Christopher J, additional, Salomaa, Veikko, additional, Rader, Daniel J, additional, Peltonen, Leena, additional, Schwartz, Stephen M, additional, Altshuler, David, additional, and Kathiresan, Sekar, additional

Published
2012
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