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205. BEAUTY FROM WITHIN

Author

Jones, Douglas

Subjects
Dietary supplements, Business, Pharmaceuticals and cosmetics industries
Abstract

The top trend that we are seeing in the market is the continued success of dietary supplements that are targeting the 'beauty from within' consumer. One of the trends that [...]

Published
2023

206. Consistency and applicability of return to function guidelines in tactical-athletes with exertional heat illness. A systematic review.

Author

O'Reilly, Matthew, Hu, Yao-Wen Eliot, Gruber, Jonathan, Jones, Douglas M., Daniel, Arthur, Marra, Janelle, and Fraser, John J.

Abstract

To assess the consistency of return to sport and occupation recommendations following EHI provided in published clinical practice guidelines, consensus statements, position statements, and practice alerts. The agreement between medical policies governing the return to duty following EHI between the branches of the United States Armed Forces and published recommendations was assessed. Ovid MEDLINE, Web of Science, and CINAHL databases were searched for clinical practice guidelines and position statements published at any time that guided return to activity in individuals with EHI. Methodological quality was assessed, and the specific recommendations for clinical management were extracted. Consistency of recommendations was evaluated. Agreement between published guidelines and the policies governing return to activity in military tactical athletes with heat injury were also evaluated. Guidelines developed by two civilian sports medicine societies in the United States detailing recommendations for return to function following EHI were identified. There was consistency between guidelines regarding recommendations that addressed abstinence from activity; medical follow-up; graded resumption of activity; and return to function. Pertaining military policy, contemporary regulations published in recent years reflected the recommendations provided in the professional guidelines. The greatest incongruence was noted in older military policies. This systematic review highlights the need for consistent recommendations across all branches of the military and medical specialties pertaining to returning servicemembers to duty after EHI. [ABSTRACT FROM AUTHOR]

Published
2023
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207. Towards an FDA-cleared basophil activation test

Author

Alpan, Oral, primary, Wasserman, Richard L., additional, Kim, Theodore, additional, Darter, Amy, additional, Shah, Atul, additional, Jones, Douglas, additional, McNeil, Donald, additional, Li, Henry, additional, Ispas, Laura, additional, Rathkopf, Melinda, additional, Perez, Elena, additional, Siri, Dareen, additional, O’Connor, Maeve, additional, Plassmeyer, Matthew, additional, Romito, Kimberly, additional, Pettibone, Christina, additional, O’Reilly, Sean, additional, Sønder, Søren Ulrik, additional, and Marti, Gerald, additional

Published
2023
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209. Protein and healthy aging

Author

Paddon-Jones, Douglas, Campbell, Wayne W, Jacques, Paul F, Kritchevsky, Stephen B, Moore, Lynn L, Rodriguez, Nancy R, and van Loon, Luc JC

Published
2015
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216. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies

Author

Kariolis, Mihalis S., Miao, Yu Rebecca, Diep, Anh, Nash, Shannon E., Olcina, Monica M., Jiang, Dadi, Jones, Douglas S. II, Kapur, Shiven, Mathews, Irimpan I., Koong, Albert C., Rankin, Erinn B., Cochran, Jennifer R., and Giaccia, Amato J.

Subjects
Metastasis -- Analysis, Chemotherapy -- Usage, Cancer -- Chemotherapy, Ovarian cancer -- Risk factors -- Care and treatment, Health care industry
Abstract

The AXL receptor and its activating ligand, growth arrest-specific 6 (GAS6), are important drivers of metastasis and therapeutic resistance in human cancers. Given the critical roles that GAS6 and AXL play in refractory disease, this signaling axis represents an attractive target for therapeutic intervention. However, the strong picomolar binding affinity between GAS6 and AXL and the promiscuity of small molecule inhibitors represent important challenges faced by current anti-AXL therapeutics. Here, we have addressed these obstacles by engineering a second-generation, high -affinity AXL decoy receptor with an apparent affinity of 93 femtomolar to GAS6. Our decoy receptor, MYD1-72, profoundly inhibited disease progression in aggressive preclinical models of human cancers and induced cell killing in leukemia cells. When directly compared with the most advanced anti-AXL small molecules in the clinic, MYD1-72 achieved superior antitumor efficacy while displaying no toxicity. Moreover, we uncovered a relationship between AXL and the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the DNA-damage markers γH2AX, 53BP1, and RAD51. MYD1-72 exploited this relationship, leading to improvements upon the therapeutic index of current standard-of-care chemotherapies in preclinical models of advanced pancreatic and ovarian cancer., Introduction With few exceptions, curative treatment protocols in clinical oncology remain reliant upon a combination of surgical resection, ionizing radiation, and cytotoxic chemotherapy. However, in many cases, the full potential [...]

Published
2017
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220. Cost of heating is on the rise in New Hampshire with winter right around the corner

Author

Jones, Douglas, Clayton, Katie, and Driscoll, And Abigail

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Douglas Jones, Katie Clayton, and Abigail Driscoll News Cost of heating is on the rise in New Hampshire with winter right around the corner. Douglas Jones, Katie Clayton, and [...]

Published
2022

228. Delivering an Immunocastration Vaccine via a Novel Subcutaneous Implant

Author

Curtis, Andrew K., primary, Jones, Douglas E., additional, Kleinhenz, Michael, additional, Montgomery, Shawnee, additional, Martin, Miriam, additional, Weeder, Mikaela, additional, Leslie, Alyssa, additional, Narasimhan, Balaji, additional, Kelly, Sean, additional, Magstadt, Drew R., additional, Colina, Alfredo, additional, and Coetzee, Johann F., additional

Published
2022
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241. On Optical Mark-Sense Scanning

Author

Jones, Douglas W., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Chaum, David, editor, Jakobsson, Markus, editor, Rivest, Ronald L., editor, Ryan, Peter Y. A., editor, Benaloh, Josh, editor, Kutylowski, Miroslaw, editor, and Adida, Ben, editor

Published
2010
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245. Cardiac Imaging and Modeling for Guidance of Minimally Invasive Beating Heart Interventions

Author

Peters, Terry M., Linte, Cristian A., Moore, John, Wiles, Andrew, Lo, Jennifer, Pace, Danielle, Wedlake, Chris, Bainbridge, Daniel, Jones, Douglas L., Guiraudon, Gerard M., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Ayache, Nicholas, editor, Delingette, Hervé, editor, and Sermesant, Maxime, editor

Published
2009
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249. Towards a Medical Virtual Reality Environment for Minimally Invasive Cardiac Surgery

Author

Peters, Terry M., Linte, Cristian A., Moore, John, Bainbridge, Daniel, Jones, Douglas L., Guiraudon, Gérard M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Dohi, Takeyoshi, editor, Sakuma, Ichiro, editor, and Liao, Hongen, editor

Published
2008
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