Search

Your search keyword '"Kazunori Hase"' showing total 286 results
Start Over Author "Kazunori Hase"
286 results on '"Kazunori Hase"'

217. DIFFERENCES IN KNEE JOINT KINEMATICS AND KINETICS DURING LEVEL WALKING AND WALKING WITH TWO TYPES OF POLES — FOCUS ON KNEE VARUS MOMENT

Author

Susumu Ota, Kazunori Hase, Hirotaka Sato, Yasuo Suzuki, Seiji Akita, and Ai Nakanishi

Subjects
musculoskeletal diseases, Orthodontics, medicine.medical_specialty, Knee joint kinematics, Knee kinematics, Osteoarthritis, Knee Joint, medicine.disease, Moment (mathematics), Gait analysis, Physical therapy, medicine, Orthopedics and Sports Medicine, Ground reaction force, human activities, Medial knee, Mathematics
Abstract

Walking with poles is one of the gait modification strategies for reducing external knee varus moments in people with medial knee osteoarthritis (OA). However, there are two types of pole techniques, Nordic walking (NW: pole back condition) and pole walking (PW: pole front condition). The purpose of this study was to investigate the differences in knee joint kinematics, and kinetics during level walking, and two types of walking with poles. A total of 22 subjects with a mean age of 21.2 years (SD: 1.3 years) participated. Three-dimensional gait analysis was conducted on level walking (LW), NW and PW. The first and second peaks of the knee kinematic and kinetic data and ground reaction forces were used. No significant differences were found between NW and PW in the knee kinematics and kinetics data. The second peak of the knee varus moment in NW and PW (0.34 and 0.33 Nm/kg, respectively) was significantly decreased compared to LW (0.42 Nm/kg, p < 0.01; Effect size = 0.70, p < 0.01; Effect size = 0.82). The first peak of the flexion moment in the knee during NW (1.2 Nm/kg) was significantly higher compared to LW (1.2 Nm/kg, p < 0.01; Effect size = 0.98). However, the present study could not clarify any different effect on the knee joint due to different instructions of the back pole and forward pole technique.

Published
2013
Full Text
View/download PDF

218. Endothelial Gi protein expression is markedly low in human coronary microvessels

Author

Shuichi Okamatsu, Kazunori Hase, Naoe Nogami, Tsunetaka Mizuki, Isao Kuwaoka, Masato Tsutsui, Hiroaki Shimokawa, and Kazuo Nakanishi

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Endothelium, Adolescent, Muscle Relaxation, Gi alpha subunit, Vasodilation, chemistry.chemical_compound, GTP-Binding Proteins, Internal medicine, parasitic diseases, Medicine, Humans, Child, Aged, Pharmacology, Aged, 80 and over, Analysis of Variance, business.industry, Microcirculation, Vasa Vasorum, Endothelium-derived relaxing factor, Infant, Newborn, Infant, Middle Aged, Coronary Vessels, Coronary arteries, medicine.anatomical_structure, chemistry, Vasa vasorum, Child, Preschool, cardiovascular system, Vascular resistance, Cardiology, population characteristics, Immunohistochemistry, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, human activities
Abstract

Gi protein functionally mediates endothelium-dependent relaxations in large epicardial coronary arteries but not in small coronary arteries, which suggests a different involvement of Gi protein in the endothelium-dependent relaxations between large and small coronary arteries. We previously showed that endothelial Gi protein is present in human epicardial coronary artery. In the present study, we examined the expression of endothelial Gi protein in human coronary microvessels. Immunohistochemical staining with a specific antibody against human Gi protein was performed in intramyocardial coronary microvessels and vasa vasorum from 34 autopsy cases. The immunoreactive levels of the endothelial Gi protein were semiquantitated into four grades (none, 0 ; slight, + 1 ; moderate, + 2 ; high, + 3), and the mean value of the ratings of all endothelial cells was then used as an index of the endothelial Gi protein expression of the vessel. The immunoreactive levels of the endothelial Gi protein were extremely low in intramyocardial coronary microvessels and in vasa vasorum, irrespective of the age of the patients, the presence or absence of coronary risk factors, or the influence of medical treatments. These results may therefore explain in part why endothelium-dependent relaxations in coronary microvessels are not functionally mediated by Gi protein.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results