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Soft magnetic amorphous materials with ultra-low power loss are highly desirable for high-frequency drive applications. The present work demonstrates the high-frequency power loss performance and underlying loss mechanisms in ultra-thin amorphous alloys. This is achieved by rapid-quenching amorphous alloys of Co-, CoFe- and Fe-rich systems, investigating their amorphous atomic structure, quantifying the saturation magnetostriction constants (λs), imaging magnetic domains at remanent magnetization, analyzing magnetization reversal from various magnetization levels, and finally, investigating the material loss performance over a broad frequency range (f = 50 kHz–2 MHz) at various excitation levels (Bm = 25–100 mT). The ultra-high performance of ultra-thin Co-rich amorphous ribbons, as compared to CoFe- and Fe-rich alloys, was attributed to the significantly low eddy current loss, due to the reduced thickness, and a minimal amount of excess loss, owning to minimal magnetoelastic contributions and magnetization reversal by rotation. The underlying loss mechanisms were analyzed by decomposing material loss into primary components and identifying the magnetization reversal mechanisms using minor hysteresis loops. In the Co-rich amorphous alloys, we suggest that magnetization reversal by rotation dominates, at least at low excitations, while in CoFe- and Fe-rich alloys domain wall displacement prevails and contributes significantly to the excess loss up to the MHz frequency range. Magnetization reversal by rotation in Co-rich alloys could be attributed to the zero/near-zero λs, and eventually low residual stress, leading to a homogeneous magnetic domain structure, as compared to the inhomogeneous “fingerprint-like” complex domains in highly magnetostrictive CoFe-rich alloys.

espanolLa impresion 3D es un proceso de manufactura que se basa en la fabricacion de prototipos, partes y piezas funcionales. Existen diferentes metodos, en los cuales se utilizan distintos materiales en diversos formatos. Uno de los metodos mas utilizados es el Modelado por Deposicion Fundida (FDM). A pesar de las ventajas que posee con respecto a otros procesos de fabricacion, la impresion 3D no esta libre de dificultades o problemas. Una de las principales problematicas se presenta al momento de configurar una impresion y tiene relacion con la eleccion de los parametros de impresion. En ocasiones, la eleccion se realiza en funcion de la experiencia de los operadores, pero cuando se requieren propiedades especificas, no se conocen los parametros a elegir. En este trabajo, se analizo la influencia del porcentaje de relleno en la resistencia a la traccion de piezas fabricadas en ABS, con una impresora Makerbot Replicator 2X. Para ello, se imprimieron probetas para ensayos de traccion, variando el porcentaje de relleno, manteniendo los demas parametros constantes. Luego fueron ensayadas y de esta manera se logro obtener la propiedad mecanica de resistencia a la traccion. Ademas, se analizo el tiempo efectivo de impresion, logrando establecer un rango recomendado de impresion en funcion de este parametro combinado con la resistencia a la traccion. La maxima resistencia a la traccion promedio, se obtuvo con un porcentaje de relleno de 100% y fue de 34,57 [MPa] English3D printing is manufacturing process that consists of the fabrication of prototypes, parts and functional pieces. Several methods can be used, with different materials in different formats. One of the most popular techniques is the Fused Deposition Modelling (FDM). This method has several advantages with respect to other manufacturing processes, although it also has some problems and difficulties. One of these problems arises when setting the printing parameters. Generally, the printing parameters are selected according to the user’s experience, although it is rather difficult to adapt the parameter settings in order to obtain specific mechanical properties of the printed parts. This work, analyzes the influence of infill on the tensile strength in parts printed with ABS, using a Makerbot Replicator 2X 3D printer. Test specimens were printed, modifying the infill, while maintaining the other parameters constant. Afterwards, the test specimens were tested in a traction test obtaining the tensile strength. In addition, the effective impression time was analyzed, in order to obtain a recommended infill ranges of impression time and tensile strength. Results showed that the maximum tensile strength was 34.57 [MPa] considering a 100% infill.

It is generally agreed upon that the mechanisms underlying task switching heavily depend on working memory, yet numerous studies have failed to show a strong relationship between working memory capacity (WMC) and task-switching ability. We argue that this relationship does indeed exist but that the dependent variable used to measure task switching is problematic. To support our claim, we reanalyzed data from two studies with a new scoring procedure that combines reaction time (RT) and accuracy into a single score. The reanalysis revealed a strong relationship between task switching and WMC that was not present when RT-based switch costs were used as the dependent variable. We discuss the theoretical implications of this finding along with the potential uses and limitations of the scoring procedure we used. More broadly, we emphasize the importance of using measures that incorporate speed and accuracy in other areas of research, particularly in comparisons of subjects differing in cognitive and developmental levels.

The Pasig River system, which includes its major tributaries, the Marikina, Taguig-Pateros, and San Juan Rivers, is the most important river system in Metro Manila. It is known to be heavily polluted due to the dumping of domestic, industrial and solid wastes. Identification of microbial species present in the riverbed may be used to assess water and soil quality, and can help in assessing the river’s capability of supporting other flora and fauna. In this study, 16S rRNA gene or 16S rDNA sequences obtained from community bacterial DNA extracted from riverbed soil of Napindan (an upstream site along the Pasig River) and Vargas (which is along the Marikina River) were used to obtain a snapshot of the types of bacteria populating these sites. The 16S rDNA sequences of amplicons produced in PCR with total DNA extracted from soil samples as template were used to build clone libraries. Four positive clones were identified from each site and were sequenced. BLAST analysis revealed that none of the contiguous sequences obtained had complete sequence similarity to any known cultured bacterial species. Using the classification output of the Ribosomal Database Project (RDP) Classifier and DECIPHER programs, 16S rDNA sequences of closely related species were collated and used to construct a neighbor-joining phylogenetic tree using MEGA6. Six out of the 8 cloned samples were found to belong to obligate anaerobe species, suggesting that these species live deep within the sediment layer and do not have access to dissolved oxygen. Three species were found to be associated with sulfate-reducing bacteria, which suggests an abundance of sulfur containing compounds in the riverbed. This is the first census report of the Pasig River microbial population using an approach that utilizes 16S rDNA sequences without culture nor isolation of bacteria. Further studies employing multiple composite samples and larger sample sizes are recommended for more comprehensive bacterial taxonomic profiles as well as evaluation of interactions between community members and bacterial response to environmental perturbations. Keywords—16S rDNA, metagenomics, Pasig River system, DNA sequence analysis, molecular phylogeny

Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study, 15 rhesus macaques were sequentially sacrificed following aerosol exposure to the MARV variant Angola, with longitudinal changes in physiology, immunology, and histopathology used to assess disease progression. Immunohistochemical evidence of infection and resulting histopathological changes were identified as early as day 3 postexposure (p.e.). The appearance of fever in infected animals coincided with the detection of serum viremia and plasma viral genomes on day 4 p.e. High (>10 7 PFU/ml) viral loads were detected in all major organs (lung, liver, spleen, kidney, brain, etc.) beginning day 6 p.e. Clinical pathology findings included coagulopathy, leukocytosis, and profound liver destruction as indicated by elevated liver transaminases, azotemia, and hypoalbuminemia. Altered cytokine expression in response to infection included early increases in Th2 cytokines such as interleukin 10 (IL-10) and IL-5 and late-stage increases in Th1 cytokines such as IL-2, IL-15, and granulocyte-macrophage colony-stimulating factor (GM-CSF). This study provides a longitudinal examination of clinical disease of aerosol MARV Angola infection in the rhesus macaque model. IMPORTANCE In this study, we carefully analyzed the timeline of Marburg virus infection in nonhuman primates in order to provide a well-characterized model of disease progression following aerosol exposure.

The mechanisms that limit the power loss performance in melt-spun amorphous ribbons have been investigated through DC and AC magnetic characterization methods. The measured total power loss is resolved into hysteresis, eddy current, and anomalous losses. The anomalous loss is found to account for more than 90% of the total loss, which significantly reduced by annealing in a transverse magnetic field. This is attributed to the reorientation of preferred magnetisation axis perpendicular to the length of ribbons. Transverse magnetic annealing promotes the relative contribution of domain rotation over domain wall motion during magnetisation reversal process. Magnetic annealing also causes a measurable decrease in the domain width, which promotes pinning and inhibits domain wall motion, thus further favoring coherent domain rotation as the primary mechanism of magnetization. This combination accounts for a 75% decrease in the total power loss in the so-processed ribbons and renders them attractive for applications in mid-and high-frequency power supplies and inverters.

The present work demonstrates the high-frequency core loss performance of Fe-based amorphous and nanocrystalline powder cores, initially produced by gas atomised powder, consolidated using sieved particles ≤20 µm, and isolated by a precise insulating layer of polymer to limit the inter- and intra-particle eddy currents to attain enhanced performance. The large glass forming ability (GFA) of the gas atomised powder, reflected by different glass forming instruments, such as the supercooled region (ΔTX = 54 °C) and the reduced glass transition temperature (Trg = 0.56), is consistent with the substantial amorphisation capability of the alloy. To the best of our knowledge, this is the first-ever report to reveal a large ΔTX in the Finemet-type alloy powders, an essential parameter to gas-atomise the amorphous powders with significantly lower cooling rates compared to the melt-spun ribbons. Further, subsequent annealing of the amorphous powders, between the exothermic events guided by differential scanning calorimetry (DSC), lead to the growth of a fine nanocrystalline structure of grains ≤15 nm, thanks to the positive enthalpy of mixing of Cu with the constituents to act as a nucleation agent, to retain the excellent soft magnetic properties. The DC soft magnetic properties of the powders were significantly improved on thermal annealing, confirmed by hysteretic loops, quantified by reduced coercivity HC

Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, domination of subordinate social targets is reinforcing. In this study, we showed that, in male mice, orexin neurons in the lateral hypothalamus activated a small population of glutamic acid decarboxylase 2 (GAD2)-expressing neurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) and that activation of these GAD2 neurons promoted male-male aggression and conditioned place preference for aggression-paired contexts. Moreover, LHb GAD2 neurons were inhibitory within the LHb and dampened the activity of the LHb as a whole. These results suggest that the orexin system is important for the regulation of inter-male aggressive behavior and provide the first functional evidence of a local inhibitory circuit within the LHb.

Fe–Si–B–Nb–Cu alloy powders, with and without P additions, were produced by gas atomization. The particles smaller than 20 μm are fully amorphous, exhibiting good soft magnetic properties. The crystallization process was studied by differential scanning calorimetry, demonstrating that its kinetics changes dramatically with small variations in the composition. The (Fe0.76Si0.09B0.10P0.05)97.5Nb2.0Cu0.5 (at. %) alloy was annealed in the supercooled liquid region (480 °C) and at the first crystallization peak (530 °C). The structural characterization by means of differential scanning calorimetry, X-ray diffraction, and transmission electron microscopy provided information that explained the excellent soft magnetic properties. Annealing at 480 °C produced an amorphous relaxed structure with improved soft magnetic properties. At 530 °C, a two-phase material formed by nanocrystals with an average grain size of 16–17 nm embedded in an amorphous matrix was developed. Partial nanocrystallization increased the saturation magnetization from 139 to 144 emu/g and reduced the coercivity from 2.24 to 0.69 Oe. These results can be understood in terms of the algebraic contribution of both phases to the magnetization and the application of the random anisotropy model to nanocrystalline soft magnetic materials.

Insulin resistance (IR) in type 2 diabetes (T2D) is associated with chronic low-grade inflammation. We have shown that nucleotide binding oligomerization domain (NOD)1, an intracellular pattern recognition receptor for bacterial wall peptidoglycans, is a factor linking the innate immune system to the development of high fat diet-induced IR. Although high fat diet may result in NOD1 activation via increased intestinal absorption of bacterial products, NOD1 has also been shown to be activated by saturated fatty acids in intestinal cells and adipocytes. We hypothesize that NOD1 plays a role in IR caused by chronic high levels of circulating free fatty acids (FFA) as found in obesity and T2D. Wild type (WT) and NOD1-/- mice were infused with ethylpalmitate (resulting in raised circulating palmitate) or ethanol vehicle as a control, for 48 hours to model prolonged elevation of circulating FFA in vivo. Hyperinsulinemic-euglycemic clamp with tracer methodology was then used to assess peripheral and hepatic insulin sensitivity. WT mice treated with ethylpalmitate had decreased peripheral and hepatic insulin sensitivity expressed as stimulation of glucose utilization (Control= 123%±30 and Ethylpalmitate= 25%±25, p Disclosure S.L. Rivers: None. L. Yeung: None. K.L. Chan: None. Y. Mori: None. D. Philpott: None. A. Klip: None. A. Giacca: None.

Soft magnetic Fe-based Fe-Si-B amorphous alloys have been widely used as magnetic components in high frequency transformers, inductors, and sensors due to their magnetic behavior [1], [2]. These materials are typically produced by the “melt-spinning” technique, involving the rapid solidification process. It is important to remark that the amorphous ribbons obtained by the melt-spinning technique were widely introduced as soft magnetic materials in the 70s. One of the ways to advance in the research field of magnetic materials involves the exploration of new routes to fabricate them. Thus, a novel technique of rapid solidification that we have successfully used to produce soft magnetic amorphous alloys is gas atomization [3], which produces the material in powder form. In this technology, it is possible to reach average cooling rates of up to $10 ^{6}\mathrm {K} /\mathrm {s}$, depending on processing conditions and the atomizing gas. The soft magnetic character of gas atomized powders with composition Fe 70 Si 18 B 12 was reported by the authors in [3]. It was showed that particles $\lt 10 \mu \mathrm {m}$ were amorphous and exhibited a low coercive field of around 7 Oe. Recently, the authors have produced a gas atomized powder of composition Fe 72.5 Si 12.5 B 15 that is fully amorphous for the whole particle size distribution, whose 90th percentile is $48.7 \mu \mathrm {m}$. Particles with a diameter $\lt 20 \mu \mathrm {m}$ exhibit a coercivity of 3.26 Oe. It is well known that a thermal treatment below the crystallization temperature leads to structural relaxation with a significant improvement of the soft magnetic character [4]. In this work, we report the effect of the thermal treatment (at 250, 350, and $450 ^{o}\mathrm {C}$ for 0 and 1 h) on the magnetic behavior of amorphous powder Fe 72.5 Si 12.5 B 15 with a particle size $\lt 20 \mu \mathrm {m}$. The annealing time of 0 h means that the sample was heated up to the annealing temperature and immediately cooled down without any holding. After such thermal treatments, the amorphous character of the annealed alloys was checked by X-ray diffraction technique. Fig. 1 shows the hysteresis loops of the annealed samples measured at room temperature, denoting the soft magnetic character associated with a very low value of coercive field. In fact, coercive field significantly decreases (see Fig. 2) from 3.26 Oe (as-atomized) to 0.44 Oe (annealed at $450 ^{o}\mathrm {C})$. There is an influence of the annealing time in this drop, with lower values of coercivity in the samples treated for 1 hour, except for the samples treated at $450 ^{o}\mathrm {C}$, whose coercivity is practically the same. The above mentioned behavior of the coercivity should be ascribed to the structural relaxation associated with thermal annealing without crystallization, decreasing the internal stresses and leading to a significant reduction of the magnetoelastic anisotropy.

Antenatal ultrasound, comprising of a dating ultrasound in the late first trimester followed by a fetal anomaly scan, is a recognised and necessary component of good antenatal care. We conducted a telephone survey of all 19 obstetric units to ascertain the status of maternity ultrasound provision in Ireland. Fetal anomaly ultrasound is offered universally to all women in 7/19 (37%) units, selectively to some women in 7/19 (37%) units and not offered at all in the remaining 5/19 (26%) units. Overall ≈ 41,700 (64%) women receive a fetal anomaly ultrasound nationally. Universal first trimester ultrasound, performed in a dedicated ultrasound department by a suitably qualified sonographer, is offered to 47% of women nationally. This study highlights the lack of development in Irish maternity ultrasound services over the last decade. Substantial investment by health care policy makers is urgently needed.

Summary Photorespiration is essential for C3 plants, enabling oxygenic photosynthesis through the scavenging of 2‐phosphoglycolate. Previous studies have demonstrated that overexpression of the L‐ and H‐proteins of the photorespiratory glycine cleavage system results in an increase in photosynthesis and growth in Arabidopsis thaliana. Here, we present evidence that under controlled environment conditions an increase in biomass is evident in tobacco plants overexpressing the H‐protein. Importantly, the work in this paper provides a clear demonstration of the potential of this manipulation in tobacco grown in field conditions, in two separate seasons. We also demonstrate the importance of targeted overexpression of the H‐protein using the leaf‐specific promoter ST‐LS1. Although increases in the H‐protein driven by this promoter have a positive impact on biomass, higher levels of overexpression of this protein driven by the constitutive CaMV 35S promoter result in a reduction in the growth of the plants. Furthermore in these constitutive overexpressor plants, carbon allocation between soluble carbohydrates and starch is altered, as is the protein lipoylation of the enzymes pyruvate dehydrogenase and alpha‐ketoglutarate complexes. Our data provide a clear demonstration of the positive effects of overexpression of the H‐protein to improve yield under field conditions.

Despite the widespread popularity of the Wonderlic Personnel Test, evidence of its validity as a measure of intelligence and personnel selection is limited. The present study sought to better understand the Wonderlic by investigating its relationship to multiple measures of working memory capacity and fluid intelligence. Our results show that Wonderlic has no direct relationship to fluid intelligence once its commonality to working memory capacity is accounted for. Further, we found that the Wonderlic was a significant predictor of working memory capacity for subjects with low fluid intelligence, but failed to discriminate as well among subjects with high fluid intelligence. These results suggest that the predictive power of the Wonderlic could depend on the characteristics of the sample it is administered to, whereas the relationship between fluid intelligence and working memory capacity is robust and invariant to the cognitive capabilities of the sample.

Gulf War illness (GWI) is a chronic disease of unknown etiology characterized by persistent symptoms such as cognitive impairment, unexplained fatigue, pervasive pain, headaches, and gastrointestinal abnormalities. Current reports suggest that as many as 200,000 veterans who served in the 1990–1991 Persian Gulf War were afflicted. Several potential triggers of GWI have been proposed including chemical exposure, toxins, vaccines, and unknown infectious agents. However, a definitive cause of GWI has not been identified and a specific biological marker that can consistently delineate the disease has not been defined. Myalgic encephalomyelitis (ME) is a disease with similar and overlapping symptomology, and subjects diagnosed with GWI typically fit the diagnostic criteria for ME. For these reasons, GWI is often considered a subgroup of ME. To explore this possibility and identify immune parameters that may help to understand GWI pathophysiology, we measured 77 serum cytokines in subjects with GWI and compared these data to that of subjects with ME as well as healthy controls. Our analysis identified a group of cytokines that identified ME and GWI cases with sensitivities of 92.5% and 64.9%, respectively. The five most significant cytokines in decreasing order of importance were IL-7, IL-4, TNF-α, IL-13, and IL-17F. When delineating GWI and ME cases from healthy controls, the observed specificity was only 33.3%, suggesting that with respect to cytokine expression, GWI cases resemble control subjects to a greater extent than ME cases across a number of parameters. These results imply that serum cytokines are representative of ME pathology to a greater extent than GWI and further suggest that the two diseases have distinct immune profiles despite their overlapping symptomology.

Background Human monkeypox is a zoonotic disease endemic to parts of Africa. Similar to other orthopoxviruses, virus and host have considerable interactions through immunomodulation. These interactions likely drive the establishment of a productive infection and disease progression, resulting in the range of disease presentations and case fatality rates observed for members of the Orthopoxvirus genus. Objectives Much of our understanding about the immune response to orthopoxvirus infection comes from either in vitro or in vivo studies performed in small animals or non-human primates. Here, we conducted a detailed assessment of cytokine responses to monkeypox virus using serum from acutely ill humans collected during monkeypox active disease surveillance (2005–2007) in the Democratic Republic of the Congo. Study design Nineteen serum samples that were from patients with confirmed monkeypox virus infections were selected for cytokine profiling. Cytokine profiling was performed on the Bio-Rad Bioplex 100 system using a 30-plex human cytokine panel. Results Cytokine profiling revealed elevated cytokine concentrations in all samples. Overproduction of certain cytokines (interleukin [IL]-2R, IL-10, and granulocyte macrophage-colony stimulating factor were observed in patients with serious disease (defined as >250 lesions based on the World Health Organization scoring system). Conclusions The data suggest that cytokine modulation affects monkeypox disease severity in humans.

The fusion gene BCR-ABL1 is present in at least the fourth part of B-cell acute lymphoblastic leukemia adult cases. Patients with this fusion gene are candidates to tyrosine kinase inhibitors treatment, and the response to this therapy can be measure by quantification of BCR-ABL1 transcripts. Some patients relapse because the presence of mutations in the tyrosine kinase domain of BCR-ABL1.This is a report of a patient with BCR-ABL1 who initially achieved molecular response with imatinib therapy, relapsing after fifteen months. The treatment was changed to dasatinib, but the patient doesn't achieve molecular response. Retrospectively, we analyzed the tyrosine kinase domain of BCR-ABL1 and we found three mutations (E459K, E255K and V299L).We conclude that gain of mutations during treatment with TKIs has strong impact in the progress of disease, being relevant the detection of BCR-ABL1 mutations in relapsed patients or in case of BCR-ABL1 persistence.

There is a debate about the ability to improve cognitive abilities such as fluid intelligence through training on tasks of working memory capacity. The question addressed in the research presented here is who benefits the most from training: people with low cognitive ability or people with high cognitive ability? Subjects with high and low working memory capacity completed a 23-session study that included 3 assessment sessions, and 20 sessions of training on 1 of 3 training regiments: complex span training, running span training, or an active-control task. Consistent with other research, the authors found that training on 1 executive function did not transfer to ability on a different cognitive ability. High working memory subjects showed the largest gains on the training tasks themselves relative to the low working memory subjects-a finding that suggests high spans benefit more than low spans from training with executive function tasks. (PsycINFO Database Record

Science is experiencing ongoing technological development that not only influences the way hypotheses can be tested with techniques but also affects the way scientists disseminate and consume scientific research. As science trainees, we are especially impacted by these changes in communication

Over the past years, we have embarked in a systematic analysis of the effect of obesity or fatty acids on circulating monocytes, microvascular endothelial cells, macrophages, and skeletal muscle cells. With the use of cell culture strategies, we have deconstructed complex physiological systems and then reconstructed “partial equations” to better understand cell-to-cell communication. Through these approaches, we identified that in high saturated fat environments, cell-autonomous proinflammatory pathways are activated in monocytes and endothelial cells, promoting monocyte adhesion and transmigration. We think of this as a paradigm of the conditions promoting immune cell infiltration into tissues during obesity. In concert, it is possible that muscle and adipose tissue secrete immune cell chemoattractants, and indeed, our tissue culture reconstructions reveal that myotubes treated with the saturated fatty acid palmitate, but not the unsaturated fatty acid palmitoleate, release nucleotides that attract monocytes and other compounds that promote proinflammatory classically activated “(M1)-like” polarization in macrophages. In addition, palmitate directly triggers an M1-like macrophage phenotype, and secretions from these activated macrophages confer insulin resistance to target muscle cells. Together, these studies suggest that in pathophysiological conditions of excess fat, the muscle, endothelial and immune cells engage in a synergistic crosstalk that exacerbates tissue inflammation, leukocyte infiltration, polarization, and consequent insulin resistance.

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Sloan Foundation Alexander von Humboldt Foundation Belgian Federal Science Policy Office Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) Ministry of Education, Youth and Sports (MEYS) of the Czech Republic Council of Science and Industrial Research, India HOMING PLUS programme of the Foundation for Polish Science European Union, Regional Development Fund Mobility Plus programme of the Ministry of Science and Higher Education National Science Center (Poland) Thalis programme - EU-ESF Aristeia programme - EU-ESF Greek NSRF National Priorities Research Program by Qatar National Research Fund Programa Clarin-COFUND del Principado de Asturias Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand) Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand) Welch Foundation A search for heavy narrow resonances decaying into four-lepton final states has been performed using proton-proton collision data at root s= 8 TeVcollected by the CMS experiment, corresponding to an integrated luminosity of 19.7fb(-1). No excess of events over the standard model background expectation is observed. Upper limits for a benchmark model on the product of cross section and branching fraction for the production of these heavy narrow resonances are presented. The limit excludes leptophobic Z' bosons with masses below 2.5 TeV within the benchmark model. This is the first result to constrain a leptophobic Z' resonance in the four-lepton channel. (C) 2017 The Author(s). Published by Elsevier B.V. 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Izmir, Turkey Marmara Univ, Istanbul, Turkey Kafkas Univ, Kars, Turkey Istanbul Bilgi Univ, Istanbul, Turkey Yildiz Tech Univ, Istanbul, Turkey Hacettepe Univ, Ankara, Turkey Univ Southampton, Sch Phys & Astron, Southampton, Hants, England Inst Astrofis Canarias, San Cristobal la Laguna, Spain Utah Valley Univ, Orem, UT USA Vinca Inst Nucl Sci, Belgrade, Serbia Univ Roma, Fac Ingn, Rome, Italy Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA Erzincan Univ, Erzincan, Turkey Mimar Sinan Univ, Istanbul, Turkey Texas A&M Univ Qatar, Doha, Qatar Univ Estadual Paulista, Sao Paulo, Brazil National Science Center (Poland): Harmonia 2014/14/M/ST2/00428 National Science Center (Poland): Opus 2014/13/B/ST2/02543 National Science Center (Poland): 2014/15/B/ST2/03998 National Science Center (Poland): 2015/19/B/ST2/02861 National Science Center (Poland): Sonata-bis 2012/07/E/ST2/01406 Welch Foundation: C-1845

The physical significance of tidal deformation in astronomical systems has long been known. The recently discovered universal I-Love-Q relations, which connect moment of inertia, quadrupole tidal Love number, and spin-induced quadrupole moment of compact stars, also underscore the special role of tidal deformation in gravitational wave astronomy. Motivated by the observation that such relations also prevail in Newtonian stars and crucially depend on the stiffness of a star, we consider the tidal Love numbers of Newtonian polytropic stars whose stiffness is characterised by a polytropic index $n$. We first perturbatively solve the Lane-Emden equation governing the profile of polytropic stars through the application of the scaled delta expansion method and then formulate perturbation series for the multipolar tidal Love number about the two exactly solvable cases with $n=0$ and $n=1$, respectively. Making use of these two series to form a two-point Pad\'e approximant, we find an approximate expression of the quadrupole tidal Love number, whose error is less than $2.5 \times 10^{-5}$ per cent (0.39 per cent) for $n\in[0,1]$ ($n\in[0,3]$). Similarly, we also determine the mass moments for polytropic stars accurately. Based on these findings, we are able to show that the I-Love-Q relations are in general stationary about the incompressible limit irrespective of the equation of state (EOS) of a star. Moreover, for the I-Love-Q relations, there is a secondary stationary point near $n \approx 0.4444$, thus showing the insensitivity to $n$ for $n\in[0,1]$. Our investigation clearly tracks the universality of the I-Love-Q relations from their validity for stiff stars such as neutron stars to their breakdown for soft stars., Comment: 17 pages, 6 figures, 5 tables To appear in MNRAS

Chronic low-grade inflammation is an important contributor to the development of insulin resistance, a hallmark of type 2 diabetes mellitus (T2DM). Obesity and high-fat feeding lead to infiltration of immune cells into metabolic tissues, promoting inflammation and insulin resistance. We hypothesized that macrophages from mice lacking NOX2 ( Cybb), an essential component of the NADPH oxidase complex highly expressed in immune cells and associated with their inflammatory response, would be less inflammatory and that these mice would be protected from the development of high-fat-induced insulin resistance. Bone marrow-derived macrophages from NOX2 knockout (NOX2-KO) mice expressed lower levels of inflammatory markers ( Nos2, Il6); however, NOX2-KO mice were hyperphagic and gained more weight than wild-type (WT) mice when fed either a chow or a high-fat (HF) diet. Surprisingly, NOX2-KO mice stored less lipid in epididymal white adipose tissue but more lipid in liver and had higher indexes of liver inflammation and macrophage infiltration than WT mice. Contrary to our hypothesis, HF-fed NOX2-KO mice were hyperinsulinemic and more insulin resistant than HF-fed WT mice, likely as a result of their higher hepatic steatosis and inflammation. In summary, NOX2 depletion promoted hyperphagia, hepatic steatosis, and inflammation with either normal or high-fat feeding, exacerbating insulin resistance. We propose that NOX2 participates in food intake control and lipid distribution in mice.

3D printing is a manufacturing process that is usually used for modeling and prototyping. One of the most popular printing techniques is fused deposition modeling (FDM), which is based on adding melted material layer by layer. Although FDM has several advantages with respect to other manufacturing materials, there are several problems that have to be faced. When setting the printing options, several parameters have to be taken into account, such as temperature, speed, infill percentage, etc. Selecting these parameters is often a great challenge for the user, and is generally solved by experience without considering the influence of variations in the parameters on the mechanical properties of the printed parts.This article analyzes the influence of the infill percentage on the mechanical properties of ABS (Acrylonitrile Butadiene Styrene) printed parts. In order to characterize this influence, test specimens for tensile strength and Charpy tests were printed with a Makerbot Replicator 2X printer, in which the infill percentage was varied but the rest of the printing parameters were kept constant. Three different results were analyzed for these tests: tensile strength, impact resistance, and effective printing time. Results showed that the maximum tensile force (1438 N) and tensile stress (34,57 MPa) were obtained by using 100 % infill. The maximum impact resistance, 1,55 J , was also obtained with 100 % infill. In terms of effective printing time, results showed that printing with an infill range between 50 % and 98 % is not recommended, since the effective printing time is higher than with a 100 % infill and the tensile strength and impact resistance are smaller. In addition, in comparing the results of our analysis with results from other authors, it can be concluded that the printer type and plastic roll significantly influence the mechanical properties of ABS parts. La impresión 3D es un proceso de manufactura que se basa en la fabricación de prototipos, partes y piezas funcionales. Existen diferentes métodos, en los cuales se utilizan distintos materiales en diversos formatos. Uno de los métodos más utilizados es el modelado por deposición fundida (FDM). A pesar de las ventajas que posee con respecto a otros procesos de fabricación, la impresión 3D no está libre de dificultades o problemas. Al momento de configurar una impresión, se deben ingresar parámetros para cada una de las variables presentes en el proceso, como por ejemplo: temperatura, velocidad, porcentaje de relleno, etc. La elección de dichos parámetros muchas veces resulta ser un problema para el operador, y generalmente se realiza en función de su experiencia, sin considerar la influencia que estos parámetros tendrán en las propiedades mecánicas del elemento terminado. Este trabajo analiza la influencia del porcentaje de relleno en la resistencia mecánica de piezas fabricadas en ABS (Acrilonitrilo Butadieno Estireno). Para ello, se imprimieron probetas para ensayo de tracción y Charpy, variando el porcentaje de relleno, y manteniendo los demás parámetros constantes. Seguido de esto, se ensayaron las probetas para obtener los valores de resistencia a la tracción y resistencia al impacto. Esto se realizó con una impresora Makerbot Replicator 2X. Además, se analizó el tiempo efectivo de impresión para conocer la variabilidad de este parámetro al modificar el porcentaje de relleno.Este estudio permitió determinar la fuerza resistente máxima que se obtuvo con un porcentaje de relleno de 100 %, fue de (1438 N), con una resistencia de (34,57 MPa). La máxima resistencia al impacto se obtuvo también con 100 % de relleno fue de 1,55J. En cuanto al tiempo de impresión, los resultados son bastante interesantes, ya que se logró identificar que en el intervalo de 50 a 98 % de relleno no es conveniente imprimir, ya que el tiempo de impresión es mayor que con 100 %, y la resistencia a la tracción y al impacto son menores, por lo que no se justifica efectuar impresiones en ese rango de porcentaje de relleno.

Previous research has identified several cognitive abilities that are important for multitasking, but few studies have attempted to measure a general multitasking ability using a diverse set of multitasks. In the final dataset, 534 young adult subjects completed measures of working memory (WM), attention control, fluid intelligence, and multitasking. Correlations, hierarchical regression analyses, confirmatory factor analyses, structural equation models, and relative weight analyses revealed several key findings. First, although the complex tasks used to assess multitasking differed greatly in their task characteristics and demands, a coherent construct specific to multitasking ability was identified. Second, the cognitive ability predictors accounted for substantial variance in the general multitasking construct, with WM and fluid intelligence accounting for the most multitasking variance compared to attention control. Third, the magnitude of the relationships among the cognitive abilities and multitasking varied as a function of the complexity and structure of the various multitasks assessed. Finally, structural equation models based on a multifaceted model of WM indicated that attention control and capacity fully mediated the WM and multitasking relationship. (PsycINFO Database Record

Working memory is a critical element of complex cognition, particularly under conditions of distraction and interference. Measures of working memory capacity correlate positively with many measures of real-world cognition, including fluid intelligence. There have been numerous attempts to use training procedures to increase working memory capacity and thereby performance on the real-world tasks that rely on working memory capacity. In the study reported here, we demonstrated that training on complex working memory span tasks leads to improvement on similar tasks with different materials but that such training does not generalize to measures of fluid intelligence.