Search

Verfassungsblog: On Matters Constitutional

Der Artikel „Holzhauser, Thorsten (2019): Die ‚Nachfolgepartei‘. Die Integration der PDS in das politische System der Bundesrepublik Deutschland 1990–2005“ von Michael Koß wurde ursprünglich am 14. April 2020 ohne „Open Access“ online auf der Internetplattform des Verlags publiziert. Der Autor hat sich jedoch nachträglich für eine „Open Access“-Veröffentlichung entschieden. Das Urheberrecht des Artikels wurde deshalb 16. Juni 2021 in © The Author(s) 2020 geändert.

Der Artikel Meinel, Florian (2019): Vertrauensfrage. Zur Krise des heutigen Parlamentarismus von Michael Koß wurde ursprünglich Online First ohne „Open Access“ auf der Internetplattform des Verlags publiziert. Nach der Veröffentlichung in Band 61 Heft 2 [pp. 191-193] hatten sich die Autoren für eine „Open Access“-Veröffentlichung entschieden. Das Urheberrecht des Artikels wurde deshalb in © Der/die Autor(en) 2020 geändert.

Die Dominanz der Volksparteien, die nach 1945 für Jahrzehnte Deutschland und Österreich geprägt hat, ist unwiderruflich vergangen. Nach dem Ende des Kalten Krieges durchkreuzen neue gesellschaftliche Konfliktlinien die bereits existierenden und damit auch die »alten« Parteien. Die Größenunterschiede zwischen »großen« und »kleinen« Parteien schrumpfen. Mehrheiten sind unter diesen Bedingungen schwerer zu organisieren.

Objective: To develop a nanoparticle (NP) platform that can expand both CD4+ and CD8+ Treg cells in vivo for the suppression of autoimmune responses in systemic lupus erythematosus (SLE). Methods: Poly(lactic-co-glycolic acid) (PLGA) NPs encapsulating interleukin-2 (IL-2) and transforming growth factor β (TGFβ) were coated with anti-CD2/CD4 antibodies and administered to mice with lupus-like disease induced by the transfer of DBA/2 T cells into (C57BL/6 × DBA/2)F1 (BDF1) mice. The peripheral frequency of Treg cells was monitored ex vivo by flow cytometry. Disease progression was assessed by measuring serum anti-double-stranded DNA antibody levels by enzyme-linked immunosorbent assay. Kidney disease was defined as the presence of proteinuria or renal histopathologic features. Results: Anti-CD2/CD4 antibody-coated, but not noncoated, NPs encapsulating IL-2 and TGFβ induced CD4+ and CD8+ FoxP3+ Treg cells in vitro. The optimal dosing regimen of NPs for expansion of CD4+ and CD8+ Treg cells was determined in in vivo studies in mice without lupus and then tested in BDF1 mice with lupus. The administration of anti-CD2/CD4 antibody-coated NPs encapsulating IL-2 and TGFβ resulted in the expansion of CD4+ and CD8+ Treg cells, a marked suppression of anti-DNA antibody production, and reduced renal disease. Conclusion: This study shows for the first time that T cell-targeted PLGA NPs encapsulating IL-2 and TGFβ can expand both CD4+ and CD8+ Treg cells in vivo and suppress murine lupus. This approach, which enables the expansion of Treg cells in vivo and inhibits pathogenic immune responses in SLE, could represent a potential new therapeutic modality in autoimmune conditions characterized by impaired Treg cell function associated with IL-2 deficiency.

Existing research on the evolution of European integration has pitted economic against identity issues. In the economic sphere, governments are arguably able to pursue their preferences more independently. If, however, identity issues become politicized this is supposed to suggest that governments lose their dominant position in integration and gradually become agents of Eurosceptic parties and/or electorates. This article looks at a phenomenon neither the intergovernmentalist nor the postfunctionalist perspective can fully explain: the emergence of the Visegrád Group (V4) as a collective actor in European politics in early 2016. This emergence occurred in the wake of the refugee crisis during which the identity issue of migration was politicized. However, there was no coherent partisan composition uniting V4 governments. Based on a sequence elaboration of all press statements of meetings of the V4 Prime Ministers since their EU-accession in 2004, we show that what at first sight appears to be informed by anti-immigrant and Eurosceptic sentiments may in fact display a more ambivalent position towards regional integration. The post-refugee crisis V4 appears as a case of politicized transnationalism—that is, cooperation to achieve transnational interests under the condition of politicization. This transnational interest not only comprised opposition to a relocation of migrants, but also the maintenance of a core transnational freedom within the EU, namely free movement under the Schengen acquis. We conclude that, under the condition of increasing politicization, identity issues help to forge government alliances of governments pursuing economic preferences.

We present visible and near-infrared photometric and spectroscopic observations of interstellar object 2I/Borisov taken from 2019 September 10 to 2019 November 29 using the GROWTH, the APO ARC 3.5 m and the NASA/IRTF 3.0 m combined with post and pre-discovery observations of 2I obtained by ZTF from 2019 March 17 to 2019 May 5. Comparison with imaging of distant Solar System comets shows an object very similar to mildly active Solar System comets with an out-gassing rate of $\sim$10$^{27}$ mol/sec. The photometry, taken in filters spanning the visible and NIR range shows a gradual brightening trend of $\sim0.03$ mags/day since 2019 September 10 UTC for a reddish object becoming neutral in the NIR. The lightcurve from recent and pre-discovery data reveals a brightness trend suggesting the recent onset of significant H$_2$O sublimation with the comet being active with super volatiles such as CO at heliocentric distances $>$6 au consistent with its extended morphology. Using the advanced capability to significantly reduce the scattered light from the coma enabled by high-resolution NIR images from Keck adaptive optics taken on 2019 October 04, we estimate a diameter of 2I's nucleus of $\lesssim$1.4 km. We use the size estimates of 1I/'Oumuamua and 2I/Borisov to roughly estimate the slope of the ISO size-distribution resulting in a slope of $\sim$3.4$\pm$1.2, similar to Solar System comets and bodies produced from collisional equilibrium., 22 pages, 7 figures, 1 table. Accepted for publication in AJ on 12 May 2020