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213 results on '"Kotaro Hattori"'

201. Association analysis of the Ser205Leu polymorphism of p75NTR with major depressive disorder

Author

Masahiko Tatsumi, Hiroaki Hori, Takashi Fujii, Kotaro Hattori, Hiroshi Kunugi, Miyako Hashikura, Daimei Sasayama, Nagahisa Okamoto, Noriko Yamamoto, Toshiya Teraishi, and Teruhiko Higuchi

Subjects
Oncology, medicine.medical_specialty, business.industry, Polymorphism (computer science), General Neuroscience, Internal medicine, Medicine, Major depressive disorder, General Medicine, business, medicine.disease, Genetic association
Published
2011

202. Genetic association analysis of phenylalanine hydroxylase and 6-pyruvoyl tetrahydropterin synthase in Japanese patients with schizophrenia and mood disorders

Author

Kotaro Hattori, Hiroshi Kunugi, Hirofumi Uchiyama, Noriko Yamamoto, Teruhiko Higuchi, Kunimasa Arima, Yoshimi Iijima, Ryota Hashimoto, Nagahisa Okamoto, Toshiya Teraishi, Masahiko Tatsumi, Hiroaki Hori, Takashi Fujii, and Mayu Omori

Subjects
medicine.medical_specialty, 6 pyruvoyl tetrahydropterin synthase, Phenylalanine hydroxylase, biology, business.industry, medicine.disease, Genetic association analysis, Psychiatry and Mental health, Endocrinology, Mood disorders, Schizophrenia, Internal medicine, medicine, biology.protein, Pharmacology (medical), business
Published
2011

203. Subject Index Vol. 63, 2011

Author

Jiří Horáček, Ingmar Gorman, Marie Balíková, Věra Bubeníková-Valešová, Francisco J. Vaz-Leal, Yuji Ozeki, Sandra Giménez, Bogdan Kontek, Félicien Karege, B. Tislerova, Mariska Bot, Jolanta Rabe-Jabłońska, François Pouwer, Druck Reinhardt Druck Basel, Yumiko Kawamoto, S. Burkhardt, P. Sos, Rafael Fernandez, Daimei Sasayama, M. Fujakova, Miguel Angel Mañanas, Kotaro Hattori, Teruhiko Higuchi, Junko Matsuo, Satz Mengensatzproduktion, Nader Perroud, Eugène H.J.M. Jansen, Hiroaki Hori, Filip Tylš, Eladia Ballmann, Tomáš Páleníček, M. Isabel Ramos-Fuentes, Martin Brunovský, Peter de Jonge, Yukiko Kinoshita, Johanna Assies, Romano La Harpe, Toshiya Teraishi, Laura Rodríguez-Santos, Aartjan T.F. Beekman, M. Angustias García-Herráiz, Sergio Romero, Vladimir Krajca, Anna Dietrich-Muszalska, M.J. Barbanoj, Hiroshi Kunugi, Alain Malafosse, and Cyril Höschl

Subjects
Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Index (economics), Statistics, Subject (documents), Biological Psychiatry, Mathematics
Published
2011

204. ANALYSES OF FYN-TYROSINE KINASE IN SCHIZOPHRENIA

Author

Yoshimi Iijima, Mayu Omori, Junko Matsuo, Yukiko Kinoshita, Masahiko Tatsumi, Kunimasa Arima, Hiroaki Hori, Nagahisa Okamoto, Noriko Yamamoto, Toshiya Teraishi, Hirofumi Uchiyama, Kotaro Hattori, Yumiko Kawamoto, Hiroshi Kunugi, Takashi Fujii, and Haruko Tanaka

Subjects
biology, MAP kinase kinase kinase, Cyclin-dependent kinase 4, Chemistry, Cyclin-dependent kinase 2, Mitogen-activated protein kinase kinase, Tropomyosin receptor kinase C, Cell biology, MAP2K7, Psychiatry and Mental health, biology.protein, Cyclin-dependent kinase 9, Janus kinase, Biological Psychiatry
Published
2010

208. Fyn protein tyrosine kinase as a target for antipsychotic drugs

Author

Kotaro Hattori, Tomoko Isosaka, Shigeki Yuasa, Shinichi Kohsaka, Takeshi Yagi, and Shigeo Uchino

Subjects
Chemistry, General Neuroscience, medicine.medical_treatment, FYN Protein, ROR1, medicine, General Medicine, Antipsychotic, Tropomyosin receptor kinase C, Tyrosine kinase, Cell biology, Proto-oncogene tyrosine-protein kinase Src
Published
2007

213. 13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients

Author

Kotaro Hattori, Naoki Yamamoto, Hiroshi Kunugi, Miho Ota, Yumiko Kawamoto, Sumio Terada, Yuji Ozeki, Toshiya Teraishi, Hiroaki Hori, Junko Matsuo, M. Kajiwara, Teruhiko Higuchi, Y. Kinoshita, Yoshimi Iijima, H. Tanaka, Daimei Sasayama, and S. Chiba

Subjects
Adult, Male, Spectrophotometry, Infrared, Dopamine, Phenylalanine, Kinetics, phenylalanine hydroxylase, Pharmacology, behavioral disciplines and activities, Cellular and Molecular Neuroscience, mental disorders, stable isotope, medicine, Haloperidol, Animals, Humans, Rats, Wistar, Biological Psychiatry, Breath test, Carbon Isotopes, Risperidone, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, Middle Aged, medicine.disease, Rats, schizophrenia, Psychiatry and Mental health, Chronic disease, Breath Tests, Schizophrenia, Chronic Disease, 13C-phenylalanine breath test, Original Article, business, metabolism, Antipsychotic Agents, medicine.drug
Abstract

Phenylalanine is an essential amino acid required for the synthesis of catecholamines including dopamine. Altered levels of phenylalanine and its metabolites in blood and cerebrospinal fluid have been reported in schizophrenia patients. This study attempted to examine for the first time whether phenylalanine kinetics is altered in schizophrenia using L-[1-(13)C]phenylalanine breath test ((13)C-PBT). The subjects were 20 chronically medicated schizophrenia patients (DSM-IV) and the same number of age- and sex-matched controls. (13)C-phenylalanine (99 atom% (13)C; 100 mg) was administered orally and the breath (13)CO(2) /(12)CO(2) ratio was monitored for 120 min. The possible effect of antipsychotic medication (risperidone (RPD) or haloperidol (HPD) treatment for 21 days) on (13)C-PBT was examined in rats. Body weight (BW), age and diagnostic status were significant predictors of the area under the curve of the time course of Δ(13)CO(2) (‰) and the cumulative recovery rate (CRR) at 120 min. A repeated measures analysis of covariance controlled for age and BW revealed that the patterns of CRR change over time differed between the patients and controls and that Δ(13)CO(2) was lower in the patients than in the controls at all sampling time points during the 120 min test, with an overall significant difference between the two groups. Chronic administration of RPD or HPD had no significant effect on (13)C-PBT indices in rats. Our results suggest that (13)C-PBT is a novel laboratory test that can detect altered phenylalanine kinetics in chronic schizophrenia patients. Animal experiments suggest that the observed changes are unlikely to be attributable to antipsychotic medication.

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