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686 results on '"Kubo, Toru"'

201. Significance of High-Sensitivity Cardiac Troponin T in Hypertrophic Cardiomyopathy

Author

Kubo, Toru, primary, Kitaoka, Hiroaki, additional, Yamanaka, Shigeo, additional, Hirota, Takayoshi, additional, Baba, Yuichi, additional, Hayashi, Kayo, additional, Iiyama, Tatsuo, additional, Kumagai, Naoko, additional, Tanioka, Katsutoshi, additional, Yamasaki, Naohito, additional, Matsumura, Yoshihisa, additional, Furuno, Takashi, additional, Sugiura, Tetsuro, additional, and Doi, Yoshinori L., additional

Published
2013
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204. Multiple coronary artery–left ventricle microfistulae

Author

Matsumura, Yoshihisa, primary, Ochi, Yuri, additional, Baba, Yuichi, additional, Tanioka, Katsutoshi, additional, Hirakawa, Daigo, additional, Wada, Michiko, additional, Hayashi, Kayo, additional, Kubo, Toru, additional, Yamasaki, Naohito, additional, Furuno, Takashi, additional, Kitaoka, Hiroaki, additional, Nishimori, Isao, additional, Sugiura, Tetsuro, additional, and Doi, Yoshinori, additional

Published
2012
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206. Influences of Donepezil on Cardiovascular System—Possible Therapeutic Benefits for Heart Failure—DOnepezil Cardiac TEst Registry (DOCTER) Study

Author

Kubo, Toru, primary, Sato, Takayuki, additional, Noguchi, Tatsuya, additional, Kitaoka, Hiroaki, additional, Yamasaki, Fumiyasu, additional, Kamimura, Naoto, additional, Shimodera, Shinji, additional, Iiyama, Tatsuo, additional, Kumagai, Naoko, additional, Kakinuma, Yoshihiko, additional, Diedrich, André, additional, Jordan, Jens, additional, Robertson, David, additional, and Doi, Yoshinori L., additional

Published
2012
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207. Complex venous malformation in an elderly female: A case report

Author

Terauchi, Yasunobu, primary, Tashiro, Miwa, additional, Kubo, Toru, additional, Nakashima, Yasuteru, additional, Ueda, Motoko, additional, Baba, Yuichi, additional, Yamasaki, Naohito, additional, Matsumura, Yoshihisa, additional, Furuno, Takashi, additional, Kitaoka, Hiroaki, additional, and Doi, Yoshinori, additional

Published
2012
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210. Combined Measurements of Cardiac Troponin I and Brain Natriuretic Peptide Are Useful for Predicting Adverse Outcomes in Hypertrophic Cardiomyopathy

Author

Kubo, Toru, primary, Kitaoka, Hiroaki, additional, Okawa, Makoto, additional, Yamanaka, Shigeo, additional, Hirota, Takayoshi, additional, Baba, Yuichi, additional, Hayato, Kayo, additional, Yamasaki, Naohito, additional, Matsumura, Yoshihisa, additional, Yasuda, Nobufumi, additional, Sugiura, Tetsuro, additional, and Doi, Yoshinori L., additional

Published
2011
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212. Turbulent left-to-right shunt flow through the interatrial septum suggesting high left atrial pressure in patients with heart failure with preserved ejection fraction

Author

Hayato, Kayo, primary, Matsumura, Yoshihisa, additional, Kawada, Yasumasa, additional, Baba, Yuichi, additional, Tanioka, Katsutoshi, additional, Okawa, Makoto, additional, Kubo, Toru, additional, Yamasaki, Naohito, additional, Kitaoka, Hiroaki, additional, Nishinaga, Masanori, additional, and Doi, Yoshinori, additional

Published
2010
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215. Clinical Features of the Dilated Phase of Hypertrophic Cardiomyopathy in Comparison With Those of Dilated Cardiomyopathy

Author

Hamada, Tomoyuki, primary, Kubo, Toru, additional, Kitaoka, Hiroaki, additional, Hirota, Takayoshi, additional, Hoshikawa, Eri, additional, Hayato, Kayo, additional, Shimizu, Yuji, additional, Okawa, Makoto, additional, Yamasaki, Naohito, additional, Matsumura, Yoshihisa, additional, Yabe, Toshikazu, additional, Takata, Jun, additional, and Doi, Yoshinori L., additional

Published
2010
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216. Development of a Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Detection of Pandemic (H1N1) 2009 Virus as a Novel Molecular Method for Diagnosis of Pandemic Influenza in Resource-Limited Settings

Author

Kubo, Toru, primary, Agoh, Masanobu, additional, Mai, Le Q., additional, Fukushima, Kiyoyasu, additional, Nishimura, Hidekazu, additional, Yamaguchi, Akinori, additional, Hirano, Manabu, additional, Yoshikawa, Akira, additional, Hasebe, Futoshi, additional, Kohno, Shigeru, additional, and Morita, Kouichi, additional

Published
2010
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219. Serum Cardiac Troponin I is Related to Increased Left Ventricular Wall Thickness, Left Ventricular Dysfunction, and Male Gender in Hypertrophic Cardiomyopathy

Author

Kubo, Toru, primary, Kitaoka, Hiroaki, additional, Okawa, Makoto, additional, Yamanaka, Shigeo, additional, Hirota, Takayoshi, additional, Hoshikawa, Eri, additional, Hayato, Kayo, additional, Yamasaki, Naohito, additional, Matsumura, Yoshihisa, additional, Yasuda, Nobufumi, additional, Sugiura, Tetsuro, additional, and Doi, Yoshinori L., additional

Published
2009
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222. Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy

Author

Arimura, Takuro, primary, Bos, J. Martijn, additional, Sato, Akinori, additional, Kubo, Toru, additional, Okamoto, Hiroshi, additional, Nishi, Hirofumi, additional, Harada, Haruhito, additional, Koga, Yoshinori, additional, Moulik, Mousumi, additional, Doi, Yoshinori L., additional, Towbin, Jeffrey A., additional, Ackerman, Michael J., additional, and Kimura, Akinori, additional

Published
2009
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229. Clinical Profiles of Hypertrophic Cardiomyopathy With Apical Phenotype Comparison of Pure-Apical Form and Distal-Dominant Form

Author

Kubo, Toru, primary, Kitaoka, Hiroaki, additional, Okawa, Makoto, additional, Hirota, Takayoshi, additional, Hoshikawa, Eri, additional, Hayato, Kayo, additional, Yamasaki, Naohito, additional, Matsumura, Yoshihisa, additional, Yabe, Toshikazu, additional, Nishinaga, Masanori, additional, Takata, Jun, additional, and Doi, Yoshinori L., additional

Published
2009
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231. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy

Author

Nakano, Noritsugu, primary, Hori, Hisae, additional, Abe, Minako, additional, Shibata, Hiroki, additional, Arimura, Takuro, additional, Sasaoka, Taishi, additional, Sawabe, Motoji, additional, Chida, Kouji, additional, Arai, Tomio, additional, Nakahara, Ken-ichi, additional, Kubo, Toru, additional, Sugimoto, Ken, additional, Katsuya, Tomohiro, additional, Ogihara, Toshio, additional, Doi, Yoshinori, additional, Izumi, Tohru, additional, and Kimura, Akinori, additional

Published
2007
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233. A novel method for rapid detection of Streptococcus pneumoniae antigens in blood.

Author

Fukushima, Kiyoyasu, Kubo, Toru, Ehara, Naomi, Nakano, Reiji, Matsutake, Toyoshi, Ishimatu, Yuji, Tanaka, Yumi, Akamatsu, Suguru, Izumikawa, Koichi, and Kohno, Shigeru

Subjects
*PNEUMONIA, *PNEUMOCOCCAL pneumonia, *PNEUMOCOCCAL vaccines, *STREPTOCOCCUS pneumoniae, *ANTIGENS
Abstract

In this study, we used “RAPIRUN ® Streptococcus pneumoniae HS (otitis media/sinusitis) (RAPIRUN-HS),” a rapid S . pneumoniae antigen detection kit, to investigate methods for detecting S . pneumoniae antigens in blood of 32 bacterial pneumonia patients. We simultaneously performed PCR to detect S . pneumoniae in blood samples. The results of these tests were compared based on pneumonia severity, determined using the Pneumonia Severity Index (PSI) score classification. Four S . pneumoniae PCR-positive patients of the six severe pneumococcal pneumonia patients (PSI risk class IV/V) also tested positive using RAPIRUN-HS. Twenty-four mild to moderate pneumonia patients (PSI risk class I–III) were S . pneumoniae PCR-negative; of these, 21 tested negative using RAPIRUN-HS. The pneumococcal pneumonia patients testing positive using RAPIRUN-HS had low leukocyte counts and elevated C-reactive protein and procalcitonin levels, indicating that RAPIRUN-HS results were correlated with pneumonia severity. The time course evaluations of the laboratory tests for severe pneumococcal pneumonia patients showed that RAPIRUN-HS and S . pneumoniae PCR yielded positive results earlier than the changes in procalcitonin and IL-6. Thus, concomitant pneumococcal bacteremia was strongly suspected in patients testing positive using RAPIRUN-HS. In conclusion, RAPIRUN-HS may be useful for determining whether to admit patients into hospitals and selecting the appropriate antimicrobial agents. [ABSTRACT FROM AUTHOR]

Published
2016
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234. Erythrocyte creatine as a marker of intravascular hemolysis due to left ventricular outflow tract obstruction in hypertrophic cardiomyopathy.

Author

Kubo, Toru, Okumiya, Toshika, Baba, Yuichi, Hirota, Takayoshi, Tanioka, Katsutoshi, Yamasaki, Naohito, Sugiura, Tetsuro, Doi, Yoshinori L., and Kitaoka, Hiroaki

Abstract

Background Erythrocyte creatine, a marker of erythrocyte age that increases with shortening of erythrocyte survival, has been reported to be a quantitative and reliable marker for intravascular hemolysis. We hypothesized that hemolysis could also occur due to intraventricular obstruction in patients with hypertrophic cardiomyopathy (HCM). The purpose of this study was to examine the presence of subclinical hemolysis and the relation between intravascular hemolysis and intraventricular pressure gradient (IVPG). Methods and results We measured erythrocyte creatine in 92 HCM patients. Twelve patients had left ventricular outflow tract obstruction (LVOTO), 4 had midventricular obstruction (MVO), and the remaining 76 were non-obstructive. Erythrocyte creatine levels ranged from 0.92 to 4.36 μmol/g hemoglobin. Higher levels of erythrocyte creatine were associated with higher IVPG ( r = 0.437, p < 0.001). If erythrocyte creatine levels are high (≥1.8 μmol/g hemoglobin), subclinical hemolysis is considered to be present. Half of LVOTO patients and no MVO patients showed high erythrocyte creatine levels. Although non-obstructive patients did not show significant intraventricular obstruction at rest, some showed high erythrocyte creatine levels. When LVOT-PG was measured during the strain phase of the Valsalva maneuver in 20 non-obstructive patients, 7 of those 20 patients showed LVOTO. In the 20 patients, there was no relation between erythrocyte creatine levels and LVOT-PG before the Valsalva maneuver ( r = 0.125, p = 0.600), whereas there was a significant correlation between erythrocyte creatine and LVOT-PG provoked by the Valsalva maneuver ( r = 0.695, p = 0.001). Conclusions There is biochemical evidence of subclinical hemolysis in patients with HCM, and this hemolysis seems to be associated with LVOTO provoked by daily physical activities. [ABSTRACT FROM AUTHOR]

Published
2016
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236. Metastatic cardiac tumor from urothelial carcinoma detected by transthoracic echocardiography: a case report.

Author

Yasuteru Nakashima, Katsutoshi Tanioka, Toru Kubo, Naohito Yamasaki, Ichiro Yamasaki, Taro Syuin, Hiroaki Kitaoka, Nakashima, Yasuteru, Tanioka, Katsutoshi, Kubo, Toru, Yamasaki, Naohito, Yamasaki, Ichiro, Syuin, Taro, and Kitaoka, Hiroaki

Subjects
METASTASIS, TRANSITIONAL cell carcinoma, ECHOCARDIOGRAPHY, ELECTROCARDIOGRAPHY, PROGNOSIS, CANCER chemotherapy, DISEASE complications
Abstract

Introduction: Cardiac metastasis of urothelial carcinoma is a very rare but clinically important complication. Most cardiac metastases are asymptomatic; symptoms from cardiac metastasis were seen in advanced stage and many of these cases were reported to have a poor prognosis. So it is important to find asymptomatic cardiac metastasis and to start chemotherapy early in order to improve the patient's prognosis.Case Presentation: A 73-year-old Asian man was referred to our hospital because of a right ventricular tumor. He had a history of left ureteral cancer 9 years ago. In screening echocardiography for paroxysmal atrial fibrillation, a low echogenic tumor was detected in his right ventricular apex, and characteristic ST segment elevation was detected in electrocardiography. An (18)F-fluorodeoxyglucose positron emission tomography revealed abnormal uptake in his right ventricular apex tumor and prostate, and a biopsy of the prostatic tumor showed urothelial carcinoma cells. He received systemic gemcitabine, paclitaxel and cisplatin chemotherapy for the urothelial carcinoma, and the cardiac tumor size was reduced temporarily. Finally, he died of multiple organ failure 16 months after his first admission, but his survival period was relatively longer than previous reports.Conclusions: We experienced a case of a metastatic cardiac tumor from urothelial carcinoma. We found asymptomatic cardiac metastasis by screening echocardiography and electrocardiography. Our patient received systemic chemotherapy and his survival period was relatively longer than previous reports. Electrocardiography and echocardiography may be useful to find asymptomatic cardiac metastasis of neoplasms. [ABSTRACT FROM AUTHOR]

Published
2015
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237. Germline mutations causing familial lung cancer.

Author

Tomoshige, Koichi, Matsumoto, Keitaro, Tsuchiya, Tomoshi, Oikawa, Masahiro, Miyazaki, Takuro, Yamasaki, Naoya, Mishima, Hiroyuki, Kinoshita, Akira, Kubo, Toru, Fukushima, Kiyoyasu, Yoshiura, Koh-ichiro, and Nagayasu, Takeshi

Subjects
GENETIC mutation, GERM cells, LUNG cancer & genetics, LUNG cancer patients, NUCLEOTIDE sequencing
Abstract

Genetic factors are important in lung cancer, but as most lung cancers are sporadic, little is known about inherited genetic factors. We identified a three-generation family with suspected autosomal dominant inherited lung cancer susceptibility. Sixteen individuals in the family had lung cancer. To identify the gene(s) that cause lung cancer in this pedigree, we extracted DNA from the peripheral blood of three individuals and from the blood of one cancer-free control family member and performed whole-exome sequencing. We identified 41 alterations in 40 genes in all affected family members but not in the unaffected member. These were considered candidate mutations for familial lung cancer. Next, to identify somatic mutations and/or inherited alterations in these 40 genes among sporadic lung cancers, we performed exon target enrichment sequencing using 192 samples from sporadic lung cancer patients. We detected somatic 'candidate' mutations in multiple sporadic lung cancer samples; MAST1, CENPE, CACNB2 and LCT were the most promising candidate genes. In addition, the MAST1 gene was located in a putative cancer-linked locus in the pedigree. Our data suggest that several genes act as oncogenic drivers in this family, and that MAST1 is most likely to cause lung cancer. [ABSTRACT FROM AUTHOR]

Published
2015
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238. Gender differences in the clinical features of hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations.

Author

Terauchi, Yasunobu, Kubo, Toru, Baba, Yuichi, Hirota, Takayoshi, Tanioka, Katsutoshi, Yamasaki, Naohito, Furuno, Takashi, and Kitaoka, Hiroaki

Abstract

Background Although gender may be one of the important factors modifying phenotypic expression in hypertrophic cardiomyopathy (HCM), there has been little information on it. Methods and results We investigated gender differences in the clinical features of HCM caused by cardiac myosin-binding protein C gene ( MYBPC3 ) mutations. Sixty-one subjects (28 families) carrying MYBPC3 mutations were studied. Of the 61 subjects with MYBPC3 mutations, 50 patients including 23 female patients were phenotype-positive by echocardiography. Disease penetrance in subjects aged ≤40 years old was 92% in males and 67% in females. Females showed delayed onset of left ventricular hypertrophy compared with males in subjects who were genotype-positive. Female patients were more symptomatic at diagnosis than were males (mean New York Heart Association class: 1.7 ± 0.8 versus 1.2 ± 0.4, p = 0.012). From a longitudinal point of view by age, no significant gender difference in cardiovascular deaths or cardiovascular events was found. During the follow-up period after diagnosis of HCM (13 ± 8 years), female patients who were phenotype-positive had significantly more frequent heart failure events than did phenotypically affected male patients ( p = 0.028). Conclusions Although females with MYBPC3 mutations showed later onset of the disease, female patients were more symptomatic at diagnosis and had more frequent heart failure events once they had developed hypertrophy. [ABSTRACT FROM AUTHOR]

Published
2015
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240. Quantitative analysis of carotid atherosclerotic lesions and high‐sensitivity C‐reactive protein in community‐dwelling elderly 80 years or older

Author

Miyano, Ichiro, primary, Takata, Jun, additional, Nishinaga, Masanori, additional, Okumiya, Kiyohito, additional, Hamada, Tomio, additional, Kubo, Toru, additional, Morita, Yukari, additional, Okawa, Makoto, additional, Yamasaki, Naohito, additional, Sato, Kyoko, additional, Matsubayashi, Kozo, additional, and Doi, Yoshinori, additional

Published
2006
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242. Long-Term Prognosis of Dilated Cardiomyopathy Revisited An Improvement in Survival Over the Past 20 Years

Author

Matsumura, Yoshihisa, primary, Takata, Jun, additional, Kitaoka, Hiroaki, additional, Kubo, Toru, additional, Baba, Yuichi, additional, Hoshikawa, Eri, additional, Hamada, Tomoyuki, additional, Okawa, Makoto, additional, Hitomi, Nobuhiko, additional, Sato, Kyoko, additional, Yamasaki, Naohito, additional, Yabe, Toshikazu, additional, Furuno, Takashi, additional, Nishinaga, Masanori, additional, and Doi, Yoshinori, additional

Published
2006
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246. Lifelong Left Ventricular Remodeling of Hypertrophic Cardiomyopathy Caused by a Founder Frameshift Deletion Mutation in the Cardiac Myosin-Binding Protein C Gene Among Japanese

Author

Kubo, Toru, primary, Kitaoka, Hiroaki, additional, Okawa, Makoto, additional, Matsumura, Yoshihisa, additional, Hitomi, Nobuhiko, additional, Yamasaki, Naohito, additional, Furuno, Takashi, additional, Takata, Jun, additional, Nishinaga, Masanori, additional, Kimura, Akinori, additional, and Doi, Yoshinori L., additional

Published
2005
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