3,341 results on '"Leipsic, Jonathon"'
Search Results
202. Long-Term Durability of Transcatheter Heart Valves: Insights From Bench Testing to 25 Years
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Sathananthan, Janarthanan, Hensey, Mark, Landes, Uri, Alkhodair, Abdullah, Saiduddin, Adeeb, Sellers, Stephanie, Cheung, Anson, Lauck, Sandra, Blanke, Philipp, Leipsic, Jonathon, Ye, Jian, Wood, David A., and Webb, John G.
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- 2020
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203. Additive diagnostic value of atherosclerotic plaque characteristics to non-invasive FFR for identification of lesions causing ischaemia: results from a prospective international multicentre trial.
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Nakazato, Ryo, Park, Hyung-Bok, Gransar, Heidi, Leipsic, Jonathon A, Budoff, Matthew J, Mancini, GB John, Erglis, Andrejs, Berman, Daniel S, and Min, James K
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Clinical Research ,Atherosclerosis ,Heart Disease ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Aged ,Coronary Angiography ,Coronary Artery Disease ,Coronary Stenosis ,Female ,Fractional Flow Reserve ,Myocardial ,Humans ,Ischemia ,Male ,Middle Aged ,Plaque ,Atherosclerotic ,Prospective Studies ,Severity of Illness Index ,Vascular Calcification ,Statistics ,Cardiovascular medicine and haematology - Abstract
AimsWe evaluated the association between atherosclerotic plaque characteristics (APCs) by CT -including positive remodelling (PR), low attenuation plaque (LAP) and spotty calcification (SC)- and lesion ischaemia by fractional flow reserve (FFR).Methods and resultsTwo hundred and fifty-two patients (17 centres, five countries) underwent CT, FFR derived from CT (FFRCT) with invasive FFR performed for 407 coronary lesions. FFR ≤0.8 was indicative of lesion-specific ischaemia. CT diameter ≥50% stenosis was considered obstructive. APCs by CT were defined as: (1) PR, lesion diameter/reference diameter >1.10; (2) LAP, any voxel
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- 2016
204. CT Angiography for the Prediction of Hemodynamic Significance in Intermediate and Severe Lesions Head-to-Head Comparison With Quantitative Coronary Angiography Using Fractional Flow Reserve as the Reference Standard
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Budoff, Matthew J, Nakazato, Ryo, Mancini, GB John, Gransar, Heidi, Leipsic, Jonathon, Berman, Daniel S, and Min, James K
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Biomedical and Clinical Sciences ,Clinical Sciences ,Atherosclerosis ,Heart Disease ,Clinical Research ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Biomedical Imaging ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Area Under Curve ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Stenosis ,Coronary Vessels ,Female ,Fractional Flow Reserve ,Myocardial ,Hemodynamics ,Humans ,Male ,Middle Aged ,Multidetector Computed Tomography ,North America ,Predictive Value of Tests ,Prognosis ,Prospective Studies ,ROC Curve ,Reference Standards ,Reproducibility of Results ,Severity of Illness Index ,coronary angiography ,coronary CT ,diagnostic accuracy ,fractional flow reserve ,multidetector computed tomography ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThe goal of this study was to compare the diagnostic performance of coronary computed tomography angiography (CTA) versus quantitative coronary angiography (QCA) for the detection of lesion-specific ischemia using fractional flow reserve (FFR) as the gold standard.BackgroundCoronary CTA has emerged as a noninvasive method for accurate detection and exclusion of high-grade coronary stenoses. FFR is the gold standard for determining lesion-specific ischemia and has been shown to improve clinical outcomes when guiding revascularization.MethodsA total of 252 patients from 5 countries were prospectively enrolled (mean age 63 years; 71% male). Patients underwent coronary CTA and invasive coronary angiography (ICA) with FFR in 407 lesions. Coronary CTA, QCA, and FFR were interpreted by independent core laboratories. Stenosis severity according to coronary CTA and QCA were graded as 0% to 29%, 30% to 49%, 50% to 69%, and 70% to 100%; stenosis ≥50% was considered anatomically obstructive. Lesion-specific ischemia was defined according to FFR ≤0.8, whereas QCA and coronary CTA stenosis ≥50% were considered obstructive. Diagnostic accuracy and areas under the receiver-operating characteristics curve (AUC) for lesion-specific ischemia was assessed.ResultsAccording to FFR, ischemia was present in 151 (37%) of 407 lesions. Diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 69%, 79%, 63%, 55%, and 83% for coronary CTA; and 71%, 74%, 70%, 59%, and 82% for QCA. AUC for identification of ischemia-causing lesions was similar: 0.75 for coronary CTA and 0.77 for QCA (p = 0.6). No differences between CTA and QCA existed for discrimination of ischemia within the left anterior descending artery (AUC 0.71 vs. 0.73; p = 0.6), left circumflex artery (AUC 0.78 vs. 0.85; p = 0.4), and right coronary artery (AUC 0.80 vs. 0.83; p = 0.6).ConclusionsCTA and ICA exhibited similar diagnostic performance for the detection and exclusion of lesion-specific ischemia. Using a true reference standard to determine appropriate revascularization targets, 3-dimensional coronary CTA performed as well as 2-dimensional ICA.
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- 2016
205. Sex-Specific Associations Between Coronary Artery Plaque Extent and Risk of Major Adverse Cardiovascular Events The CONFIRM Long-Term Registry
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Schulman-Marcus, Joshua, Hartaigh, Bríain Ó, Gransar, Heidi, Lin, Fay, Valenti, Valentina, Cho, Iksung, Berman, Daniel, Callister, Tracy, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz, Budoff, Matthew, Kaufmann, Philipp, Achenbach, Stephan, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Rubinshtein, Ronen, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Shaw, Leslee, and Min, James K
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Prevention ,Biomedical Imaging ,Atherosclerosis ,Clinical Research ,Cardiovascular ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Aged ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Artery Disease ,Coronary Stenosis ,Coronary Vessels ,Disease Progression ,Europe ,Female ,Follow-Up Studies ,Humans ,Incidence ,Kaplan-Meier Estimate ,Male ,Middle Aged ,Multidetector Computed Tomography ,Myocardial Infarction ,North America ,Plaque ,Atherosclerotic ,Predictive Value of Tests ,Prevalence ,Prognosis ,Proportional Hazards Models ,Prospective Studies ,Registries ,Republic of Korea ,Risk Factors ,Severity of Illness Index ,Sex Distribution ,Sex Factors ,Time Factors ,CAD ,CT coronary angiography ,sex differences ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThe purpose of this study was to examine sex-specific associations, if any, between per-vessel coronary artery disease (CAD) extent and the risk of major adverse cardiovascular events (MACE) over a 5-year study duration.BackgroundThe presence and extent of CAD diagnosed by coronary computed tomography angiography (CTA) is associated with increased short-term mortality and MACE. Nevertheless, some uncertainty remains regarding the influence of sex on these findings.Methods5,632 patients (mean age 60.2 ± 11.8 years, 36.5% women) from the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry were followed for 5 years. Obstructive CAD was defined as ≥50% luminal stenosis in a coronary vessel. Using Cox proportional hazards models, we calculated the hazard ratio (HR) for incident MACE among women and men, defined as death or myocardial infarction.ResultsObstructive CAD was more prevalent in men (42% vs. 26%; p < 0.001), whereas women were more likely to have normal coronary arteries (43% vs. 27%; p < 0.001). There were a total of 798 incident MACE events. After adjustment, there was a strong association between increased MACE risk and nonobstructive CAD (HR: 2.16 for women, 2.56 for men; p < 0.001 for both), obstructive 1-vessel CAD (HR: 3.69 and 2.66; p < 0.001), 2-vessel CAD (HR: 3.92 and 3.55; p < 0.001), and 3-vessel/left main CAD (HR: 5.94 and 4.44; p < 0.001). Further exploratory analyses of atherosclerotic burden did not identify sex-specific patterns predictive of MACE.ConclusionsIn a large prospective coronary CTA cohort followed long-term, we did not observe an interaction of sex for the association between MACE risk and increased per-vessel extent of obstructive CAD. These findings highlight the persistent prognostic significance of anatomic CAD subsets as detected by coronary CTA for the risk of MACE in both women and men.
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- 2016
206. Long term prognostic utility of coronary CT angiography in patients with no modifiable coronary artery disease risk factors: Results from the 5 year follow-up of the CONFIRM International Multicenter Registry
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Cheruvu, Chaitu, Precious, Bruce, Naoum, Christopher, Blanke, Philipp, Ahmadi, Amir, Soon, Jeanette, Arepalli, Chesnaldey, Gransar, Heidi, Achenbach, Stephan, Berman, Daniel S, Budoff, Matthew J, Callister, Tracy Q, Al-Mallah, Mouaz H, Cademartiri, Filippo, Chinnaiyan, Kavitha, Rubinshtein, Ronen, Marquez, Hugo, DeLago, Augustin, Villines, Todd C, Hadamitzky, Martin, Hausleiter, Joerg, Shaw, Leslee J, Kaufmann, Philipp A, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Maffei, Erica, Raff, Gilbert, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Min, James K, and Leipsic, Jonathon
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Biomedical Imaging ,Atherosclerosis ,Cardiovascular ,Clinical Research ,Heart Disease - Coronary Heart Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Coronary Angiography ,Coronary Artery Disease ,Female ,Follow-Up Studies ,Humans ,Incidence ,Internationality ,Longitudinal Studies ,Male ,Middle Aged ,Prognosis ,Proportional Hazards Models ,Registries ,Reproducibility of Results ,Risk Assessment ,Sensitivity and Specificity ,Survival Analysis ,Tomography ,X-Ray Computed ,Coronary computed tomographic angiography ,Coronary artery disease ,All-cause mortality ,Major adverse cardiovascular events ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Applied computing - Abstract
BackgroundCoronary computed tomography angiography (coronary CTA) can prognosticate outcomes in patients without modifiable risk factors over medium term follow-up. This ability was driven by major adverse cardiovascular events (MACE).ObjectiveDetermine if coronary CTA could discriminate risk of mortality with longer term follow-up. In addition we sought to determine the long-term relationship to MACE.MethodsFrom 12 centers, 1884 patients undergoing coronary CTA without prior coronary artery disease (CAD) or any modifiable CAD risk factors were identified. The presence of CAD was classified as none (0% stenosis), mild (1% to 49% stenosis) and obstructive (≥50% stenosis severity). The primary endpoint was all-cause mortality and the secondary endpoint was MACE. MACE was defined as the combination of death, nonfatal myocardial infarction, unstable angina, and late target vessel revascularization (>90 days).ResultsMean age was 55.6 ± 14.5 years. At mean 5.6 ± 1.3 years follow-up, 145(7.7%) deaths occurred. All-cause mortality demonstrated a dose-response relationship to the severity and number of coronary vessels exhibiting CAD. Increased mortality was observed for >1 segment non-obstructive CAD (hazard ratio [HR]:1.73; 95% confidence interval [CI]: 1.07-2.79; p = 0.025), obstructive 1&2 vessel CAD (HR: 1.70; 95% CI: 1.08-2.71; p = 0.023) and 3-vessel or left main CAD (HR: 2.87; 95% CI: 1.57-5.23; p = 0.001). Both obstructive CAD (HR: 6.63; 95% CI: 3.91-11.26; p 5 years) was predicted by the presence of more than 1 segment of non-obstructive plaque, obstructive 1- or 2-vessel CAD and 3 vessel/left main CAD. Any CAD, whether non-obstructive or obstructive, predicted MACE over the same time period.
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- 2016
207. Feasibility and accuracy of real-time 3D-holographic graft length measurement
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Tsai, Tsung-Ying, primary, Kageyama, Shigetaka, additional, He, XingQiang, additional, Pompilio, Giulio, additional, Andreini, Daniele, additional, Pontone, Gianluca, additional, La Meir, Mark, additional, De Mey, Johan, additional, Tanaka, Kaoru, additional, Doenst, Torsten, additional, Puskas, John, additional, Teichgräber, Ulf, additional, Schneider, Ulrich, additional, Gupta, Himanshu, additional, Leipsic, Jonathon, additional, Garg, Scot, additional, C Revaiah, Pruthvi, additional, Stanuch, Maciej, additional, Skalski, Andrzej, additional, Onuma, Yoshinobu, additional, and Serruys, Patrick W, additional
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- 2023
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208. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
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Hahn, Rebecca T., primary, Lawlor, Matthew K., additional, Davidson, Charles J., additional, Badhwar, Vinay, additional, Sannino, Anna, additional, Spitzer, Ernest, additional, Lurz, Philipp, additional, Lindman, Brian R., additional, Topilsky, Yan, additional, Baron, Suzanne J., additional, Chadderdon, Scott, additional, Khalique, Omar K., additional, Tang, Gilbert H.L., additional, Taramasso, Maurizio, additional, Grayburn, Paul A., additional, Badano, Luigi, additional, Leipsic, Jonathon, additional, Lindenfeld, JoAnn, additional, Windecker, Stephan, additional, Vemulapalli, Sreekanth, additional, Redfors, Bjorn, additional, Alu, Maria C., additional, Cohen, David J., additional, Rodés-Cabau, Josep, additional, Ailawadi, Gorav, additional, Mack, Michael, additional, Ben-Yehuda, Ori, additional, Leon, Martin B., additional, Hausleiter, Jörg, additional, Arnold, Suzanne, additional, Bapat, Vinayak, additional, Berry, Natalia, additional, Blanke, Philipp, additional, Burkhoff, Daniel, additional, Coylewright, Megan, additional, Duggal, Neal, additional, Galper, Benjamin, additional, George, Isaac, additional, Guerrero, Mayra, additional, Hamid, Nadira, additional, Jagadeesan, Vikrant, additional, Kodali, Susheel, additional, Krucoff, Mitch, additional, Lang, Roberto, additional, Madhavan, Mahesh, additional, McLaughin, Vallerie, additional, Mehran, Roxana, additional, Philippon, Francois, additional, Sethi, Sanjum S., additional, Simonato, Matheus, additional, Smith, Robert, additional, Sodhi, Nishtha, additional, Spertus, John, additional, Stocker, Thomas J., additional, and Stone, Gregg, additional
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- 2023
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209. Transcatheter Mitral Valve Replacement
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Husain, Ali, primary, Meier, David, additional, Dundas, James, additional, Akodad, Mariama, additional, Jelisejevas, Julius, additional, Zaky, Fady, additional, Moss, Robert, additional, Sathananthan, Gnalini, additional, Sellers, Stephanie L., additional, Leipsic, Jonathon A., additional, Blanke, Philipp, additional, Wood, David A., additional, Sathananthan, Janarthanan, additional, Boone, Robert, additional, and Webb, John G., additional
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- 2023
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210. Systemic Inflammation With High-Sensitivity C-Reactive Protein and Atherosclerotic Plaque Progression
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Bienstock, Solomon, primary, Lee, Sang-Eun, additional, Lin, Fay, additional, Blankstein, Ron, additional, Leipsic, Jonathon, additional, Patel, Krishna, additional, Narula, Jagat, additional, Chandrashekhar, Y.S., additional, Fuster, Valentin, additional, and Shaw, Leslee J., additional
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- 2023
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211. Comprehensive Myocardial Assessment by Computed Tomography
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Koike, Hideki, primary, Fukui, Miho, additional, Treibel, Thomas, additional, Stanberry, Larissa I., additional, Cheng, Victor Y., additional, Enriquez-Sarano, Maurice, additional, Schmidt, Stephanie, additional, Schelbert, Erik B., additional, Wang, Cheng, additional, Okada, Atsushi, additional, Phichaphop, Asa, additional, Sorajja, Paul, additional, Bapat, Vinayak N., additional, Leipsic, Jonathon, additional, Lesser, John R., additional, and Cavalcante, João L., additional
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- 2023
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212. Case Report: Stretching the limits—late valvuloplasty for THV dysfunction following redo mitral valve-in-valve implantation
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Meier, David, primary, Tzimas, Georgios, additional, Akodad, Mariama, additional, Husain, Ali, additional, Dundas, James, additional, Jelisejevas, Julius, additional, Cheung, Anson, additional, Sellers, Stephanie L., additional, Leipsic, Jonathon A., additional, Blanke, Philipp, additional, Wood, David A., additional, Sathananthan, Janarthanan, additional, and Webb, John G., additional
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- 2023
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213. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
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Hahn, Rebecca T, primary, Lawlor, Matthew K, additional, Davidson, Charles J, additional, Badhwar, Vinay, additional, Sannino, Anna, additional, Spitzer, Ernest, additional, Lurz, Philipp, additional, Lindman, Brian R, additional, Topilsky, Yan, additional, Baron, Suzanne J, additional, Chadderdon, Scott, additional, Khalique, Omar K, additional, Tang, Gilbert H L, additional, Taramasso, Maurizio, additional, Grayburn, Paul A, additional, Badano, Luigi, additional, Leipsic, Jonathon, additional, Lindenfeld, JoAnn, additional, Windecker, Stephan, additional, Vemulapalli, Sreekanth, additional, Redfors, Bjorn, additional, Alu, Maria C, additional, Cohen, David J, additional, Rodés-Cabau, Josep, additional, Ailawadi, Gorav, additional, Mack, Michael, additional, Ben-Yehuda, Ori, additional, Leon, Martin B, additional, and Hausleiter, Jörg, additional
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- 2023
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214. TCT-430 Prognostic Value of Combined Coronary CT Angiography–Derived Fractional Flow Reserve and Quantitative Plaque Analysis in Patients With Stable Angina
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Madsen, Kristian Taekker, primary, Norgaard, Bjarne, additional, Øvrehus, Kristian, additional, Jensen, Jesper, additional, Parner, Erik, additional, Grove, Erik, additional, Mortensen, Martin Bødtker, additional, Iraqi, Nadia, additional, Nieman, Koen, additional, Patel, Manesh, additional, Rogers, Campbell, additional, Mullen, Sarah, additional, Mickley, Hans, additional, Rohold, Allan, additional, Leipsic, Jonathon, additional, and Rønnow Sand, Niels Peter, additional
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- 2023
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215. TCT-289 Concordance of Heart Team Plannings and Actual Treatment of Coronary Surgery Based on Invasive and Noninvasive Coronary Angiography
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Kageyama, Shigetaka, primary, Serruys, Patrick, additional, Pompilio, Giulio, additional, Andreini, Daniele, additional, La Meir, Mark, additional, De Mey, Johan, additional, Narula, Jagat, additional, Doenst, Torsten, additional, Teichgräber, Ulf, additional, Mushtaq, Saima, additional, Tanaka, Kaoru, additional, Schneider, Ulrich, additional, Miyashita, Kotaro, additional, Kotoku, Nozomi, additional, Revaiah, Pruthvi Chenniganahosahalli, additional, Ninomiya, Kai, additional, Tsai, TsungYing, additional, Leipsic, Jonathon, additional, Morel, Marie-Angele, additional, and Onuma, Yoshinobu, additional
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- 2023
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216. 2023 CCS/CSE Standards for Physician Training and Maintenance of Competence in Adult Echocardiography: Executive Summary
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Nair, Parvathy, primary, Chen-Tournoux, Annabel, additional, Almufleh, Aws S., additional, Blissett, Sarah, additional, Ducas, Robin, additional, Fine, Nowell M., additional, Johri, Amer M., additional, Kushneriuk, Dominique, additional, Ramer, Sarah, additional, Sanfilippo, Anthony, additional, Thibodeau-Jarry, Nicolas, additional, Yu, Eric, additional, Bewick, David, additional, Burwash, Ian G., additional, Chow, Chi-Ming, additional, Cooley, Heather, additional, De, Sabe, additional, Douflé, Ghislaine, additional, Fagan, Susan M., additional, Henri, Christine, additional, Jassal, Davinder S., additional, Jelic, Tom, additional, Lee, Dana, additional, Leipsic, Jonathon, additional, Leong-Poi, Howard, additional, Luksun, Warren, additional, Mulloy, Andrew J., additional, Mulvagh, Sharon, additional, Nesbitt, Gillian, additional, Promislow, Steven, additional, Sebag, Igal A., additional, Tran, Diem T.T., additional, and Tsang, Teresa S.M., additional
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- 2023
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217. Impact of Coronary CT Angiography–derived Fractional Flow Reserve on Downstream Management and Clinical Outcomes in Individuals with and without Diabetes
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Gulsin, Gaurav S., primary, Tzimas, Georgios, additional, Holmes, Kenneth-Royce, additional, Takagi, Hidenobu, additional, Sellers, Stephanie L., additional, Blanke, Philipp, additional, Koweek, Lynne M. H., additional, Nørgaard, Bjarne L., additional, Jensen, Jesper, additional, Rabbat, Mark G., additional, Pontone, Gianluca, additional, Fairbairn, Timothy A., additional, Chinnaiyan, Kavitha M., additional, Douglas, Pamela S., additional, Huey, Whitney, additional, Matsuo, Hitoshi, additional, Sand, Niels P. R., additional, Nieman, Koen, additional, Bax, Jeroen J., additional, Amano, Tetsuya, additional, Kawasaki, Tomohiro, additional, Akasaka, Takashi, additional, Rogers, Campbell, additional, Berman, Daniel S., additional, Patel, Manesh R., additional, De Bruyne, Bernard, additional, Mullen, Sarah, additional, and Leipsic, Jonathon A., additional
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- 2023
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218. TCT-292 Regional Disparity of the Bypass Strategy and Graft Patent Rate in the First-in-Man Trial of Coronary Surgical Revascularization Solely Guided on Multislice Computed Tomography
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Kageyama, Shigetaka, primary, Serruys, Patrick, additional, Pompilio, Giulio, additional, Andreini, Daniele, additional, La Meir, Mark, additional, De Mey, Johan, additional, Narula, Jagat, additional, Doenst, Torsten, additional, Teichgräber, Ulf, additional, Mushtaq, Saima, additional, Tanaka, Kaoru, additional, Schneider, Ulrich, additional, Tobe, Akihiro, additional, Miyashita, Kotaro, additional, Kotoku, Nozomi, additional, Revaiah, Pruthvi Chenniganahosahalli, additional, Ninomiya, Kai, additional, Tsai, TsungYing, additional, Leipsic, Jonathon, additional, Morel, Marie-Angele, additional, and Onuma, Yoshinobu, additional
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- 2023
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219. The Canadian Cardiovascular Society Classification of Acute Atherothrombotic Myocardial Infarction Based on Stages of Tissue Injury Severity: An Expert Consensus Statement
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Kumar, Andreas, primary, Connelly, Kim, additional, Vora, Keyur, additional, Bainey, Kevin R., additional, Howarth, Andrew, additional, Leipsic, Jonathon, additional, Betteridge-LeBlanc, Suzanne, additional, Prato, Frank S., additional, Leong-Poi, Howard, additional, Main, Anthony, additional, Atoui, Rony, additional, Saw, Jacqueline, additional, Larose, Eric, additional, Graham, Michelle M., additional, Ruel, Marc, additional, and Dharmakumar, Rohan, additional
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- 2023
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220. TCT-428 Coronary CT Angiography–Derived Fractional Flow Reserve and Risk of Recurrent Angina in Stable Coronary Artery Disease: A 3-Year Follow-up Study
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Madsen, Kristian Taekker, primary, Norgaard, Bjarne, additional, Øvrehus, Kristian, additional, Jensen, Jesper, additional, Parner, Erik, additional, Grove, Erik, additional, Mortensen, Martin Bødtker, additional, Iraqi, Nadia, additional, Nieman, Koen, additional, Patel, Manesh, additional, Rogers, Campbell, additional, Mullen, Sarah, additional, Mickley, Hans, additional, Thomsen, Kristian, additional, Leipsic, Jonathon, additional, and Rønnow Sand, Niels Peter, additional
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- 2023
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221. CT-Derived Plaque Physiology and Characterization
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Leipsic, Jonathon A., primary and Tzimas, Georgios, additional
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- 2023
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222. Progression of non-obstructive coronary plaque: a practical CCTA-based risk score from the PARADIGM registry
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Pontone, Gianluca, primary, Rossi, Alexia, additional, Baggiano, Andrea, additional, Andreini, Daniele, additional, Conte, Edoardo, additional, Fusini, Laura, additional, Gebhard, Chaterine, additional, Rabbat, Mark G., additional, Guaricci, Andrea, additional, Guglielmo, Marco, additional, Muscogiuri, Giuseppe, additional, Mushtaq, Saima, additional, Al-Mallah, Mouaz H., additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Choi, Jung Hyun, additional, Chun, Eun Ju, additional, de Araújo Gonçalves, Pedro, additional, Gottlieb, Ilan, additional, Hadamitzky, Martin, additional, Kim, Yong Jin, additional, Lee, Byoung Kwon, additional, Lee, Sang-Eun, additional, Maffei, Erica, additional, Marques, Hugo, additional, Samady, Habib, additional, Shin, Sanghoon, additional, Sung, Ji Min, additional, van Rosendael, Alexander, additional, Virmani, Renu, additional, Bax, Jeroen J., additional, Leipsic, Jonathon A., additional, Lin, Fay Y., additional, Min, James K., additional, Narula, Jagat, additional, Shaw, Leslee J., additional, and Chang, Hyuk-Jae, additional
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- 2023
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223. Accuracy of a virtual PCI planner based on coronary CT angiography in calcific lesions
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Belmonte, Marta, primary, Maeng, Michael, additional, Collet, Carlos, additional, Norgaard, Bjarne L., additional, Otake, Hiromasa, additional, Ko, Brian, additional, Koo, Bon-Kwon, additional, Mizukami, Takuya, additional, Updegrove, Adam, additional, Barbato, Emanuele, additional, De Bruyne, Bernard, additional, Leipsic, Jonathon, additional, Taylor, Charles, additional, Andreini, Daniele, additional, and Sonck, Jeroen, additional
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- 2023
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224. Clinical Importance of Fontan Circuit Thrombus in the Adult Population: Significant Association With Increased Risk of Cardiovascular Events
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Sathananthan, Gnalini, Johal, Niall, Verma, Tony, Sandhu, Sherry, Chakrabarti, Shantabanu, Riahi, Mounir, Human, Derek, Leipsic, Jonathon, and Grewal, Jasmine
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- 2019
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225. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study
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Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Junior, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Shorofsky, Matthew, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Aaron, Shawn D., Sin, Don D., O’Donnell, Denis E., Maltais, François, Walker, Brandie L., and Kaminska, Marta
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- 2019
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226. Risk Reclassification With Coronary Computed Tomography Angiography-Visualized Nonobstructive Coronary Artery Disease According to 2018 American College of Cardiology/American Heart Association Cholesterol Guidelines (from the Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes : An International Multicenter Registry [CONFIRM])
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Han, Donghee, Beecy, Ashley, Anchouche, Khalil, Gransar, Heidi, Dunham, Patricia C., Lee, Ji-Hyun, Achenbach, Stephan, Al-Mallah, Mouaz H., Andreini, Daniele, Berman, Daniel S., Bax, Jeroen J., Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo C., DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A., Kim, Yong-Jin, Leipsic, Jonathon A., Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Pontone, Gianluca, Raff, Gilbert L., Rubinshtein, Ronen, Villines, Todd C., Lu, Yao, Peña, Jessica M., Shaw, Leslee J., Min, James K., and Lin, Fay Y.
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- 2019
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227. Guiding Therapy by Coronary CT Angiography Improves Outcomes in Patients With Stable Chest Pain
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Adamson, Philip D., Williams, Michelle C., Dweck, Marc R., Mills, Nicholas L., Boon, Nicholas A., Daghem, Marwa, Bing, Rong, Moss, Alastair J., Mangion, Kenneth, Flather, Marcus, Forbes, John, Hunter, Amanda, Norrie, John, Shah, Anoop S.V., Timmis, Adam D., van Beek, Edwin J.R., Ahmadi, Amir A., Leipsic, Jonathon, Narula, Jagat, Newby, David E., Roditi, Giles, McAllister, David A., and Berry, Colin
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- 2019
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228. From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events: JACC State-of-the-Art Review
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Ahmadi, Amir, Argulian, Edgar, Leipsic, Jonathon, Newby, David E., and Narula, Jagat
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- 2019
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229. Impact of Sublingual Nitroglycerin on the Assessment of Computed Tomography–derived Fractional Flow Reserve: An Intraindividual Comparison Study
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Gao, Yifeng, Wang, Wenjing, Wang, Hongwei, Zhou, Zhen, Xu, Pengpeng, Jiang, Mengdi, Yang, Lin, Wang, Hui, Wen, Hui, Sun, Zhonghua, Leipsic, Jonathon A., Zhang, Longjiang, and Xu, Lei
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- 2022
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230. Cardiac MRI measurements of pericardial adipose tissue volumes in patients on in-centre nocturnal hemodialysis
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Cai, Sean, Wald, Ron, Deva, Djeven P., Kiaii, Mercedeh, Ng, Ming-Yen, Karur, Gauri R., Bello, Oblugbenga, Li, Zhuo Jun, Leipsic, Jonathon, Jimenez-Juan, Laura, Kirpalani, Anish, Connelly, Kim A., and Yan, Andrew T.
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- 2020
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231. Coronary dominance and prognosis in patients undergoing coronary computed tomographic angiography: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry
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Gebhard, Catherine, Fuchs, Tobias A, Stehli, Julia, Gransar, Heidi, Berman, Daniel S, Budoff, Matthew J, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha M, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin, Gomez, Millie J, Hadamitzky, Martin, Hausleiter, Joerg, Hindoyan, Niree, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Dunning, Allison M, Min, James K, and Kaufmann, Philipp A
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Atherosclerosis ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Biomedical Imaging ,Clinical Research ,Cardiovascular ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Coronary Angiography ,Coronary Artery Disease ,Female ,Humans ,Male ,Middle Aged ,Prognosis ,Prospective Studies ,Radiographic Image Interpretation ,Computer-Assisted ,Registries ,Risk Factors ,Tomography ,X-Ray Computed ,Coronary dominance ,Coronary computed tomographic angiography ,Predictive value ,Cardiovascular medicine and haematology - Abstract
AimsCoronary computed tomographic angiography (CCTA) has become an important tool for non-invasive diagnosis of coronary artery disease (CAD). Coronary dominance can be assessed by CCTA; however, the predictive value of coronary dominance is controversially discussed. The aim of this study was to evaluate the prevalence and prognosis of coronary dominance in a large prospective, international multicentre cohort of patients undergoing CCTA.Methods and resultsThe study population consisted of 6382 patients with or without CAD (47% females, 53% males, mean age 56.9 ± 12.3 years) who underwent CCTA and were followed over a period of 60 months. Right or left coronary dominance was determined. Right dominance was present in 91% (n = 5817) and left in 9% (n = 565) of the study population. At the end of follow-up, outcome in patients with obstructive CAD (>50% luminal stenosis) and right dominance was similar compared with patients with left dominance [hazard ratio (HR) 0.46, 95% CI 0.16-1.32, P = 0.15]. Furthermore, no differences were observed for the type of coronary dominance in patients with non-obstructive CAD (HR 0.95, 95% CI 0.41-2.21, P = 0.8962) or normal coronary arteries (HR 1.04, 95% CI 0.68-1.59, P = 0.9). Subgroup analysis in patients with left main disease revealed an elevated hazard of the combined endpoint for left dominance (HR 6.45, 95% CI 1.66-25.0, P = 0.007), but not for right dominance.ConclusionIn our study population, survival after 5 years of follow-up did not differ significantly between patients with left or right coronary dominance. Thus, assessment of coronary vessel dominance by CCTA may not enhance risk stratification in patients with normal coronary arteries or obstructive CAD, but may add prognostic information for specific subpopulations.
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- 2015
232. Current trends in patients with chronic total occlusions undergoing coronary CT angiography
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Opolski, Maksymilian P, Hartaigh, Bríain Ó, Berman, Daniel S, Budoff, Matthew J, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A, Leipsic, Jonathon, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, and Min, James K
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Atherosclerosis ,Heart Disease ,Age Factors ,Aged ,Canada ,Cardiovascular Agents ,Chi-Square Distribution ,Chronic Disease ,Comorbidity ,Coronary Angiography ,Coronary Artery Bypass ,Coronary Occlusion ,Coronary Stenosis ,Europe ,Female ,Humans ,Logistic Models ,Male ,Middle Aged ,Multidetector Computed Tomography ,Multivariate Analysis ,Odds Ratio ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Prevalence ,Prospective Studies ,Registries ,Republic of Korea ,Risk Factors ,Sex Factors ,Smoking ,Time Factors ,Treatment Outcome ,United States ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectiveData describing the prevalence, characteristics and management of coronary chronic total occlusions (CTOs) in patients undergoing coronary CT angiography (CCTA) have not been reported. The purpose of this study was to determine the prevalence, characteristics and treatment strategies of CTO identified by CCTA.MethodsWe identified 23 745 patients who underwent CCTA for suspected coronary artery disease (CAD) from the prospective international CCTA registry. Baseline clinical data were collected, and allocation to early coronary revascularisation performed within 90 days of CCTA was determined. Multivariable hierarchical mixed-effects logistic regression reporting OR with 95% CI was performed.ResultsThe prevalence of CTO was 1.4% (342/23 745) in all patients and 6.2% in patients with obstructive CAD (≥50% stenosis). The presence of CTO was independently associated with male sex (OR 3.12, 95% CI 2.39 to 4.08, p
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- 2015
233. Medical History for Prognostic Risk Assessment and Diagnosis of Stable Patients with Suspected Coronary Artery Disease
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Min, James K, Dunning, Allison, Gransar, Heidi, Achenbach, Stephan, Lin, Fay Y, Al-Mallah, Mouaz, Budoff, Matthew J, Callister, Tracy Q, Chang, Hyuk-Jae, Cademartiri, Filippo, Maffei, Erica, Chinnaiyan, Kavitha, Chow, Benjamin JW, D'Agostino, Ralph, DeLago, Augustin, Friedman, John, Hadamitzky, Martin, Hausleiter, Joerg, Hayes, Sean W, Kaufmann, Philipp, Raff, Gilbert L, Shaw, Leslee J, Thomson, Louise, Villines, Todd, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Marques, Hugo, Berman, Daniel S, and Pencina, Michael
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Health Sciences ,Biomedical Imaging ,Heart Disease ,Cardiovascular ,Atherosclerosis ,Clinical Research ,Heart Disease - Coronary Heart Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Adolescent ,Adult ,Algorithms ,Coronary Angiography ,Coronary Artery Disease ,Female ,Humans ,Male ,Medical History Taking ,Middle Aged ,Myocardial Infarction ,Prognosis ,Proportional Hazards Models ,Reproducibility of Results ,Risk Assessment ,Risk Factors ,Tomography ,X-Ray Computed ,Young Adult ,Coronary artery disease ,Diagnosis ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveTo develop a clinical cardiac risk algorithm for stable patients with suspected coronary artery disease based upon angina typicality and coronary artery disease risk factors.MethodsBetween 2004 and 2011, 14,004 adults with suspected coronary artery disease referred for cardiac imaging were followed: 1) 9093 patients for coronary computed tomography angiography (CCTA) followed for 2.0 years (CCTA-1); 2) 2132 patients for CCTA followed for 1.6 years (CCTA-2); and 3) 2779 patients for exercise myocardial perfusion scintigraphy (MPS) followed for 5.0 years. A best-fit model from CCTA-1 for prediction of death or myocardial infarction was developed, with integer values proportional to regression coefficients. Discrimination was assessed using C-statistic. The validated model was tested for estimation of the likelihood of obstructive coronary artery disease, defined as ≥50% stenosis, as compared with the method of Diamond and Forrester. Primary outcomes included all-cause mortality and nonfatal myocardial infarction. Secondary outcomes included prevalent angiographically obstructive coronary artery disease.ResultsIn CCTA-1, best-fit model discriminated individuals at risk of death or myocardial infarction (C-statistic 0.76). The integer model ranged from 3 to 13, corresponding to 3-year death risk or myocardial infarction of 0.25% to 53.8%. When applied to CCTA-2 and MPS cohorts, the model demonstrated C-statistics of 0.71 and 0.77, respectively. Both best-fit (C = 0.76; 95% confidence interval [CI], 0.746-0.771) and integer models (C = 0.71; 95% CI, 0.693-0.719) performed better than Diamond and Forrester (C = 0.64; 95% CI, 0.628-0.659) for estimating obstructive coronary artery disease.ConclusionsFor stable symptomatic patients with suspected coronary artery disease, we developed a history-based method for prediction of death and obstructive coronary artery disease.
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- 2015
234. Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry.
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Otaki, Yuka, Gransar, Heidi, Cheng, Victor Y, Dey, Damini, Labounty, Troy, Lin, Fay Y, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Dunning, Allison, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S, and Min, James K
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Humans ,Genetic Predisposition to Disease ,Tomography ,X-Ray Computed ,Coronary Angiography ,Severity of Illness Index ,Registries ,Prevalence ,Risk Factors ,Prospective Studies ,Sex Factors ,Adult ,Female ,Male ,Coronary Artery Disease ,coronary CT angiography ,coronary artery disease ,coronary risk factors ,young adults ,Heart Disease ,Clinical Research ,Clinical Trials and Supportive Activities ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,2.1 Biological and endogenous factors ,Aetiology ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
ObjectivePrior studies examining coronary atherosclerosis in the young have been limited by retrospective analyses in small cohorts. We examined the relationship between cardiovascular risk factors (RFs) and prevalence and severity of coronary atherosclerosis in a large, prospective, multinational registry of consecutive young individuals undergoing coronary computerized tomographic angiography (CCTA).Method and resultsOf 27 125 patients undergoing CCTA, 1635 young (
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- 2015
235. Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography
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Nakanishi, Rine, Berman, Daniel S, Budoff, Matthew J, Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Jörg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Dunning, Allison, and Min, James K
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Biomedical and Clinical Sciences ,Clinical Sciences ,Atherosclerosis ,Heart Disease ,Clinical Research ,Biomedical Imaging ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Prevention ,Respiratory ,Coronary Angiography ,Coronary Artery Disease ,Epidemiologic Methods ,Female ,Humans ,Male ,Middle Aged ,Myocardial Infarction ,Plaque ,Atherosclerotic ,Prognosis ,Smoking ,Tomography ,X-Ray Computed ,Smoking risk ,Coronary atherosclerosis ,Coronary computed tomographic angiography ,Major adverse cardiovascular risk ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
AimsWe evaluated coronary artery disease (CAD) extent, severity, and major adverse cardiac events (MACEs) in never, past, and current smokers undergoing coronary CT angiography (CCTA).Methods and resultsWe evaluated 9456 patients (57.1 ± 12.3 years, 55.5% male) without known CAD (1588 current smokers; 2183 past smokers who quit ≥3 months before CCTA; and 5685 never smokers). By risk-adjusted Cox proportional-hazards models, we related smoking status to MACE (all-cause death or non-fatal myocardial infarction). We further performed 1:1:1 propensity matching for 1000 in each group evaluate event risk among individuals with similar age, gender, CAD risk factors, and symptom presentation. During a mean follow-up of 2.8 ± 1.9 years, 297 MACE occurred. Compared with never smokers, current and past smokers had greater atherosclerotic burden including extent of plaque defined as segments with any plaque (2.1 ± 2.8 vs. 2.6 ± 3.2 vs. 3.1 ± 3.3, P < 0.0001) and prevalence of obstructive CAD [1-vessel disease (VD): 10.6% vs. 14.9% vs. 15.2%, P < 0.001; 2-VD: 4.4% vs. 6.1% vs. 6.2%, P = 0.001; 3-VD: 3.1% vs. 5.2% vs. 4.3%, P < 0.001]. Compared with never smokers, current smokers experienced higher MACE risk [hazard ratio (HR) 1.9, 95% confidence interval (CI) 1.4-2.6, P < 0.001], while past smokers did not (HR 1.2, 95% CI 0.8-1.6, P = 0.35). Among matched individuals, current smokers had higher MACE risk (HR 2.6, 95% CI 1.6-4.2, P < 0.001), while past smokers did not (HR 1.3, 95% CI 0.7-2.4, P = 0.39). Similar findings were observed for risk of all-cause death.ConclusionAmong patients without known CAD undergoing CCTA, current and past smokers had increased burden of atherosclerosis compared with never smokers; however, risk of MACE was heightened only in current smokers.
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- 2015
236. A Clinical Model to Identify Patients With High-Risk Coronary Artery Disease
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Yang, Yelin, Chen, Li, Yam, Yeung, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jörg, Karlsberg, Ronald P, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon, LaBounty, Troy, Lin, Fay, Maffei, Erica, Raff, Gilbert L, Shaw, Leslee J, Villines, Todd C, Min, James K, and Chow, Benjamin JW
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Atherosclerosis ,Prevention ,Heart Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Aged ,Coronary Angiography ,Coronary Artery Disease ,Female ,Humans ,Male ,Middle Aged ,Predictive Value of Tests ,Registries ,Retrospective Studies ,Risk Assessment ,Risk Factors ,Tomography ,X-Ray Computed ,computed tomographic coronary angiography ,high-risk coronary artery disease ,risk factors ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThis study sought to develop a clinical model that identifies patients with and without high-risk coronary artery disease (CAD).BackgroundAlthough current clinical models help to estimate a patient's pre-test probability of obstructive CAD, they do not accurately identify those patients with and without high-risk coronary anatomy.MethodsRetrospective analysis of a prospectively collected multinational coronary computed tomographic angiography (CTA) cohort was conducted. High-risk anatomy was defined as left main diameter stenosis ≥50%, 3-vessel disease with diameter stenosis ≥70%, or 2-vessel disease involving the proximal left anterior descending artery. Using a cohort of 27,125, patients with a history of CAD, cardiac transplantation, and congenital heart disease were excluded. The model was derived from 24,251 consecutive patients in the derivation cohort and an additional 7,333 nonoverlapping patients in the validation cohort.ResultsThe risk score consisted of 9 variables: age, sex, diabetes, hypertension, current smoking, hyperlipidemia, family history of CAD, history of peripheral vascular disease, and chest pain symptoms. Patients were divided into 3 risk categories: low (≤7 points), intermediate (8 to 17 points) and high (≥18 points). The model was statistically robust with area under the curve of 0.76 (95% confidence interval [CI]: 0.75 to 0.78) in the derivation cohort and 0.71 (95% CI: 0.69 to 0.74) in the validation cohort. Patients who scored ≤7 points had a low negative likelihood ratio (
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- 2015
237. Prognostic and Therapeutic Implications of Statin and Aspirin Therapy in Individuals With Nonobstructive Coronary Artery Disease
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Chow, Benjamin JW, Small, Gary, Yam, Yeung, Chen, Li, McPherson, Ruth, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gundrun, Hadamitzky, Martin, Hausleiter, Jörg, Karlsberg, Ronald P, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon, LaBounty, Troy, Lin, Fay, Maffei, Erica, Raff, Gilbert L, Shaw, Leslee J, Villines, Todd C, and Min, James K
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Patient Safety ,Cardiovascular ,Heart Disease ,Atherosclerosis ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Evaluation of treatments and therapeutic interventions ,Detection ,screening and diagnosis ,6.1 Pharmaceuticals ,4.2 Evaluation of markers and technologies ,Good Health and Well Being ,Adult ,Aged ,Asia ,Aspirin ,Canada ,Coronary Angiography ,Coronary Artery Disease ,Coronary Stenosis ,Europe ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Kaplan-Meier Estimate ,Male ,Middle Aged ,Multivariate Analysis ,Odds Ratio ,Platelet Aggregation Inhibitors ,Predictive Value of Tests ,Primary Prevention ,Proportional Hazards Models ,Prospective Studies ,Protective Factors ,Registries ,Risk Factors ,Severity of Illness Index ,Time Factors ,Tomography ,X-Ray Computed ,Treatment Outcome ,United States ,aspirin ,coronary angiography ,coronary atherosclerosis ,mortality ,prognosis ,statin ,CONFIRM Investigators ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
ObjectiveWe sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and to determine the impact of baseline statin and aspirin use on mortality.Approach and resultsCoronary computed tomographic angiography permits direct visualization of nonobstructive CAD. To date, the prognostic implications of nonobstructive CAD and the potential benefit of directing therapy based on nonobstructive CAD have not been carefully examined. A total of 27 125 consecutive patients who underwent computed tomographic angiography (12 enrolling centers and 6 countries) were prospectively entered into the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry. Patients, without history of previous CAD or obstructive CAD, for whom baseline statin and aspirin use was available were analyzed. Each coronary segment was classified as normal or nonobstructive CAD (1%-49% stenosis). Patients were followed up for a median of 27.2 months for all-cause mortality. The study comprised 10 418 patients (5712 normal and 4706 with nonobstructive CAD). In multivariable analyses, patients with nonobstructive CAD had a 6% (95% confidence interval, 1%-12%) higher risk of mortality for each additional segment with nonobstructive plaque (P=0.021). Baseline statin use was associated with a reduced risk of mortality (hazard ratio, 0.44; 95% confidence interval, 0.28-0.68; P=0.0003), a benefit that was present for individuals with nonobstructive CAD (hazard ratio, 0.32; 95% confidence interval, 0.19-0.55; P
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- 2015
238. Diagnostic accuracy and discrimination of ischemia by fractional flow reserve CT using a clinical use rule: Results from the Determination of Fractional Flow Reserve by Anatomic Computed Tomographic Angiography study
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Thompson, Angus G, Raju, Rekha, Blanke, Philipp, Yang, Tae-hyun, Mancini, Giovanni Battista John, Budoff, Matthew J, Norgaard, Bjarne L, Min, James K, and Leipsic, Jonathon A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Biomedical Imaging ,Heart Disease ,Clinical Research ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Age Factors ,Aged ,Area Under Curve ,Cohort Studies ,Coronary Angiography ,Coronary Artery Disease ,Female ,Fractional Flow Reserve ,Myocardial ,Humans ,Male ,Middle Aged ,Myocardial Ischemia ,Prospective Studies ,Risk Assessment ,Sensitivity and Specificity ,Severity of Illness Index ,Sex Factors ,Tomography ,X-Ray Computed ,Coronary CT angiography ,Fractional flow reserve ,Computational fluid dynamics ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Applied computing - Abstract
BackgroundFractional flow reserve (FFR) is the gold standard for determining lesion-specific ischemia. Computed FFRCT derived from coronary CT angiography (coronary CTA) correlates well with invasive FFR and accurately differentiates between ischemia-producing and nonischemic lesions. The diagnostic performance of FFRCT when applied in a clinically relevant way to all vessels ≥ 2 mm in diameter stratified by sex and age has not been previously examined.MethodsTwo hundred fifty-two patients and 407 vessels underwent coronary CTA, FFRCT, invasive coronary angiography, and invasive FFR. FFRCT and FFR ≤ 0.80 were considered ischemic, whereas CT stenosis ≥ 50% was considered obstructive. The diagnostic performance of FFRCT was assessed following a prespecified clinical use rule which included all vessels ≥ 2 mm in diameter, not just those assessed by invasive FFR measurements. Stenoses 90% were assigned an FFR of 0.50. Diagnostic performance of FFRCT was stratified by vessel diameter, sex, and age.ResultsBy FFR, ischemia was identified in 129 of 252 patients (51%) and in 151 of 407 vessels (31%). Mean age (± standard deviation) was 62.9 ± 9 years, and women were older (65.5 vs 61.9 years; P = .003). Per-patient diagnostic accuracy (83% vs 72%; P < .005) and specificity (54% vs 82%, P < .001) improved significantly after application of the clinical use tool. These were significantly improved over standard coronary CTA values before application of the clinical use rule. Discriminatory power of FFRCT also increased compared with baseline (area under the receiver operating characteristics curve [AUC]: 0.93 vs 0.81, P < .001). Diagnostic performance improved in both sexes with no significant differences between the sexes (AUC: 0.93 vs 0.90, P = .43). There were no differences in the discrimination of FFRCT after application of the clinical use rule when stratified by age ≥ 65 or 2 mm in diameter. FFRCT has similar diagnostic accuracy and discriminatory power for ischemia detection in men and women irrespective of age using a cut point of 65 years.
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- 2015
239. A randomized, multicenter, multivendor study of myocardial perfusion imaging with regadenoson CT perfusion vs single photon emission CT
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Cury, Ricardo C, Kitt, Therese M, Feaheny, Kathleen, Blankstein, Ron, Ghoshhajra, Brian B, Budoff, Matthew J, Leipsic, Jonathon, Min, James K, Akin, Jamie, and George, Richard T
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Biomedical and Clinical Sciences ,Clinical Sciences ,Biomedical Imaging ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Heart Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Aged ,Confidence Intervals ,Coronary Angiography ,Coronary Stenosis ,Female ,Humans ,Male ,Middle Aged ,Myocardial Infarction ,Myocardial Ischemia ,Myocardial Perfusion Imaging ,Observer Variation ,Purines ,Pyrazoles ,Sensitivity and Specificity ,Tomography ,Emission-Computed ,Single-Photon ,Tomography ,X-Ray Computed ,Regadenoson ,CT perfusion ,Myocardial ischemia ,Single photon emission CT ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Applied computing - Abstract
BackgroundMyocardial CT perfusion (CTP) is a promising tool for the detection of myocardial ischemia. We hypothesize that regadenoson CTP is noninferior to regadenoson single photon emission CT (SPECT) for detecting or excluding myocardial ischemia.MethodsPatients (men ≥ 45 years; women ≥ 50 years) with known or suspected coronary artery disease (n = 124) were randomized to 1 of 2 diagnostic sequences: rest and regadenoson SPECT on day 1, then regadenoson CTP and rest CTP (and coronary CT angiography [CTA]) (CTA; same acquisition) on day 2 or regadenoson CTP and rest CTP (and CTA) on Day 1, then rest and regadenoson SPECT on day 2. Scanning platforms included 64-, 128-, 256-, and 320-slice systems. The primary analysis examined the agreement rate between CTP and SPECT for detecting or excluding reversible ischemia in ≥ 2 myocardial segments as assessed by independent, blinded readers.ResultsComplete and interpretable CTP and SPECT scans were obtained for 110 patients. Regadenoson CTP was noninferior to SPECT for detecting or excluding reversible ischemia with an agreement rate of 0.87 (95% confidence interval [CI], 0.77-0.97) and sensitivity and specificity of 0.90 (95% CI, 0.71-1.00) and 0.84 (95% CI, 0.77-0.91), respectively. The agreement rate for detecting or excluding ≥ 1 fixed defects by regadenoson CTP and SPECT was 0.86 (95% CI, 0.74-0.98). With SPECT as the reference standard, the diagnostic accuracies for detecting or excluding ischemia by regadenoson CTP and CTA alone were 0.85 (95% CI, 0.78-0.91) and 0.69 (95% CI, 0.60-0.77), respectively.ConclusionsThis study establishes the noninferiority of regadenoson CTP to SPECT for detecting or excluding myocardial ischemia.
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- 2015
240. Incremental prognostic utility of coronary CT angiography for asymptomatic patients based upon extent and severity of coronary artery calcium: results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) Study
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Cho, Iksung, Chang, Hyuk-Jae, Hartaigh, Bríain Ó, Shin, Sanghoon, Sung, Ji Min, Lin, Fay Y, Achenbach, Stephan, Heo, Ran, Berman, Daniel S, Budoff, Matthew J, Callister, Tracy Q, Al-Mallah, Mouaz H, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Dunning, Allison M, DeLago, Augustin, Villines, Todd C, Hadamitzky, Martin, Hausleiter, Joerg, Leipsic, Jonathon, Shaw, Leslee J, Kaufmann, Philipp A, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Maffei, Erica, Raff, Gilbert, Pontone, Gianluca, Andreini, Daniele, and Min, James K
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Cardiovascular ,Patient Safety ,Heart Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Coronary Angiography ,Coronary Stenosis ,Female ,Humans ,Kaplan-Meier Estimate ,Male ,Middle Aged ,Myocardial Infarction ,Prognosis ,Risk Assessment ,Tomography ,X-Ray Computed ,Vascular Calcification ,Coronary computed tomographic angiography ,Coronary artery calcium scoring ,Framingham risk score ,Asymptomatic ,Prognostic ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
AimPrior evidence observed no predictive utility of coronary CT angiography (CCTA) over the coronary artery calcium score (CACS) and the Framingham risk score (FRS), among asymptomatic individuals. Whether the prognostic value of CCTA differs for asymptomatic patients, when stratified by CACS severity, remains unknown.Methods and resultsFrom a 12-centre, 6-country observational registry, 3217 asymptomatic individuals without known coronary artery disease (CAD) underwent CACS and CCTA. Individuals were categorized by CACS as: 0-10, 11-100, 101-400, 401-1000, >1000. For CCTA analysis, the number of obstructive vessels-as defined by the per-patient presence of a ≥50% luminal stenosis-was used to grade the extent and severity of CAD. The incremental prognostic value of CCTA over and above FRS was measured by the likelihood ratio (LR) χ(2), C-statistic, and continuous net reclassification improvement (NRI) for prediction, discrimination, and reclassification of all-cause mortality and non-fatal myocardial infarction. During a median follow-up of 24 months (25th-75th percentile, 17-30 months), there were 58 composite end-points. The incremental value of CCTA over FRS was demonstrated in individuals with CACS >100 (LRχ(2), 25.34; increment in C-statistic, 0.24; NRI, 0.62, all P < 0.001), but not among those with CACS ≤100 (all P > 0.05). For subgroups with CACS >100, the utility of CCTA for predicting the study end-point was evident among individuals whose CACS ranged from 101 to 400; the observed predictive benefit attenuated with increasing CACS.ConclusionCoronary CT angiography provides incremental prognostic utility for prediction of mortality and non-fatal myocardial infarction for asymptomatic individuals with moderately high CACS, but not for lower or higher CACS.
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- 2015
241. Atherosclerotic Plaque Characteristics by CT Angiography Identify Coronary Lesions That Cause Ischemia A Direct Comparison to Fractional Flow Reserve
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Park, Hyung-Bok, Heo, Ran, Hartaigh, Bríain Ó, Cho, Iksung, Gransar, Heidi, Nakazato, Ryo, Leipsic, Jonathon, Mancini, GB John, Koo, Bon-Kwon, Otake, Hiromasa, Budoff, Matthew J, Berman, Daniel S, Erglis, Andrejs, Chang, Hyuk-Jae, and Min, James K
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Atherosclerosis ,Heart Disease ,Coronary Angiography ,Coronary Occlusion ,Female ,Fractional Flow Reserve ,Myocardial ,Humans ,Male ,Middle Aged ,Plaque ,Atherosclerotic ,Tomography ,X-Ray Computed ,coronary artery disease ,coronary computed tomography angiography ,coronary plaque ,fractional flow reserve ,myocardial ischemia ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThis study evaluated the association between atherosclerotic plaque characteristics (APCs) by coronary computed tomographic angiography (CTA), and lesion ischemia by fractional flow reserve (FFR).BackgroundFFR is the gold standard for determining lesion ischemia. Although APCs by CTA-including aggregate plaque volume % (%APV), positive remodeling (PR), low attenuation plaque (LAP), and spotty calcification (SC)-are associated with future coronary syndromes, their relationship to lesion ischemia is unclear.Methods252 patients (17 centers, 5 countries; mean age 63 years; 71% males) underwent coronary CTA, with FFR performed for 407 coronary lesions. Coronary CTA was interpreted for 1.10; 2) LAP, any voxel
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- 2015
242. Effects of cardiac medications for patients with obstructive coronary artery disease by coronary computed tomographic angiography: Results from the multicenter CONFIRM registry
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Schulman-Marcus, Joshua, Hartaigh, Bríain Ó, Giambrone, Ashley E, Gransar, Heidi, Valenti, Valentina, Berman, Daniel S, Budoff, Matthew J, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Dunning, Allison, and Min, James K
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Atherosclerosis ,Biomedical Imaging ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Heart Disease ,Aged ,Algorithms ,Cohort Studies ,Coronary Angiography ,Coronary Artery Disease ,Female ,Heart ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Male ,Middle Aged ,Proportional Hazards Models ,Registries ,Tomography ,X-Ray Computed ,Treatment Outcome ,Coronary artery disease ,Coronary computed tomographic ,angiography ,Major adverse cardiac events ,Medication therapy ,Statins ,Coronary computed tomographic angiography ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectiveThis study sought to determine the correlation between baseline cardiac medications and cardiovascular outcomes in patients with obstructive coronary artery disease (CAD) diagnosed by coronary computed tomographic angiography (CCTA).Methods1637 patients (mean age 64.8 ± 10.2 years, 69.6% male) with obstructive CAD from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry were followed over the course of three years. Obstructive CAD was defined as a ≥50% stenosis in an epicardial vessel. Medications analyzed included statins, aspirin, beta-blockers, angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). Using Cox proportional-hazards models, we calculated the hazard ratio (HR) with 95% confidence intervals (95% CIs) for incident major adverse cardiovascular events (MACE), defined as death, acute coronary syndrome, or myocardial infarction.ResultsAt the time of CCTA, 59%, 54%, 40%, and 46% of patients were using statins, aspirin, beta-blockers, and ACE inhibitors or ARBs, respectively. Statins were associated with a 43% (95% CI = 0.38-0.87, p = 0.008) lower adjusted risk of MACE. Following adjustment, aspirin, beta-blockers, ACE inhibitors and ARBs did not attenuate the risk of MACE. When restricted to patients with multivessel obstructive CAD, only statins were associated with lower risk of MACE.ConclusionIn patients with obstructive CAD by CCTA, the baseline use of statins was associated with improved clinical outcomes. Other cardiac medications-including aspirin, beta-blockers, ACE inhibitors, and ARBs-were not associated with reduced risk of MACE.
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- 2015
243. Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM).
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Ahmadi, Amir, Leipsic, Jonathon, Feuchtner, Gudrun, Gransar, Heidi, Kalra, Dan, Heo, Ran, Achenbach, Stephan, Andreini, Daniele, Al-Mallah, Mouaz, Berman, Daniel S, Budoff, Matthew, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin, Cury, Ricardo C, Delago, Augustin, Gomez, Millie J, Hadamitzky, Martin, Hausleiter, Joerg, Hindoyan, Niree, Kaufmann, Philipp A, Kim, Yong-Jin, Lin, Fay, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert L, Shaw, Leslee J, Villines, Todd C, Dunning, Allison, and Min, James K
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Humans ,Myocardial Infarction ,Tomography ,X-Ray Computed ,Coronary Angiography ,Prognosis ,Angioplasty ,Severity of Illness Index ,Registries ,Prevalence ,Risk Assessment ,Risk Factors ,Survival Analysis ,Cohort Studies ,International Cooperation ,Aged ,Middle Aged ,Female ,Male ,Coronary Artery Disease ,Acute Coronary Syndrome ,Metabolic Syndrome ,Tomography ,X-Ray Computed ,General Science & Technology - Abstract
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p > 0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p = 0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p = 0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.
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- 2015
244. Impact of sublingual nitroglycerin dosage on FFRCT assessment and coronary luminal volume–to–myocardial mass ratio
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Holmes, Kenneth R., Fonte, Tim A., Weir-McCall, Jonathan, Anastasius, Malcolm, Blanke, Philipp, Payne, Geoffrey W., Ellis, Jen, Murphy, Darra T., Taylor, Charles, Leipsic, Jonathon A., and Sellers, Stephanie L.
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- 2019
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245. Computed Tomography Imaging for Aortic Valve Disease
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Ohana, Mickaël, Shaw, Anthony, Grover, Romi, Mooney, John, Leipsic, Jonathon, Blanke, Philipp, Tamburino, Corrado, editor, Barbanti, Marco, editor, and Capodanno, Davide, editor
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- 2018
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246. Computed Tomography Imaging for Mitral Valve Regurgitation
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Grover, Rominder, Blanke, Philipp, Kueh, Shaw-Hua, Sellers, Stephanie, Leipsic, Jonathon A., Tamburino, Corrado, editor, Barbanti, Marco, editor, and Capodanno, Davide, editor
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- 2018
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247. Valvular Diseases and Interventions
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Blanke, Philipp, Thompson, Angus, Leipsic, Jonathon, Budoff, Matthew J., editor, Achenbach, Stephan S., editor, Hecht, Harvey S., editor, and Narula, Jagat, editor
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- 2018
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248. Sex-based Prognostic Implications of Nonobstructive Coronary Artery Disease: Results from the International Multicenter CONFIRM Study
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Leipsic, Jonathon, Taylor, Carolyn M, Gransar, Heidi, Shaw, Leslee J, Ahmadi, Amir, Thompson, Angus, Humphries, Karin, Berman, Daniel S, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, and Min, James K
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Patient Safety ,Cardiovascular ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Aging ,Atherosclerosis ,6.1 Pharmaceuticals ,Detection ,screening and diagnosis ,Evaluation of treatments and therapeutic interventions ,4.2 Evaluation of markers and technologies ,Good Health and Well Being ,Cardiac-Gated Imaging Techniques ,Contrast Media ,Coronary Angiography ,Coronary Artery Disease ,Female ,Humans ,Male ,Middle Aged ,Prognosis ,Prospective Studies ,Registries ,Risk Assessment ,Risk Factors ,Severity of Illness Index ,Sex Factors ,Surveys and Questionnaires ,Tomography ,X-Ray Computed ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging - Abstract
PurposeTo determine the clinical outcomes of women and men with nonobstructive coronary artery disease ( CAD coronary artery disease ) with coronary computed tomographic (CT) angiography data in patients who were similar in terms of CAD coronary artery disease risk factors, angina typicality, and CAD coronary artery disease extent and distribution.Materials and methodsInstitutional review board approval was obtained for all participating sites, with either informed consent or waiver of informed consent. In a prospective international multicenter cohort study of 27 125 patients undergoing coronary CT angiography at 12 centers, 18 158 patients with no CAD coronary artery disease or nonobstructive (
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- 2014
249. Anatomic and Functional Discordance Among Patients With Nonobstructive Coronary Disease
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Rymer, Jennifer A., Ng, Nicholas, Takagi, Hidenobu, Koweek, Lynne M., Douglas, Pamela S., De Bruyne, Bernard, Norgaard, Bjarne L., Patel, Manesh R., Leipsic, Jonathon A., and Daubert, Melissa A.
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- 2024
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250. Long-Term Outcomes of the FORMA Transcatheter Tricuspid Valve Repair System for the Treatment of Severe Tricuspid Regurgitation: Insights From the First-in-Human Experience
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Asmarats, Lluis, Perlman, Gidon, Praz, Fabien, Hensey, Mark, Chrissoheris, Michael P., Philippon, Francois, Ofek, Hadass, Ye, Jian, Puri, Rishi, Pibarot, Philippe, Attinger, Adrian, Moss, Robert, Bédard, Elisabeth, Moschovitis, Aris, Reineke, David, Lauck, Sandra, Blanke, Philipp, Leipsic, Jonathon, Spargias, Konstantinos, Windecker, Stephan, Webb, John G., and Rodés-Cabau, Josep
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- 2019
- Full Text
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