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Summary: Recent studies have shown that PM2.5 may activate the hypothalamus-pituitary-adrenal (HPA) axis by inducing hormonal changes, potentially explaining the increase in neurological and cardiovascular risks. In addition, an association between PM2.5 and gut microbiota and metabolites was established. The above evidence represents crucial parts of the gut-brain axis (GBA). In view of this evidence, we proposed a hypothesis that PM2.5 exposure may affect the HPA axis through the gastrointestinal tract microbiota pathway (GBA mechanism), leading to an increased risk of neurological and cardiovascular diseases. We conducted a real-world prospective repeated panel study in Jinan, China. At each visit, we measured real-time personal PM2.5 and collected fecal and blood samples. A linear mixed-effects model was used to analyze the association between PM2.5 and serum biomarkers, gut microbiota, and metabolites. We found that PM2.5 was associated with increased serum levels of hormones, especially the adrenocorticotropic hormone (ACTH) and cortisol, which are reliable hormones of the HPA axis. Gut microbiota and tryptophan metabolites and inflammation, which are important components of the GBA, were significantly associated with PM2.5. We also found links between PM2.5 and changes in the nervous and cardiovascular outcomes, e.g., increases of 19.77% (95% CI: −36.44, 125.69) in anxiety, 1.19% (95% CI: 0.65, 1.74) in fasting blood glucose (FBG), 2.09% (95% CI: 1.48, 2.70) in total cholesterol (TCHOL), and 0.93% (95% CI: 0.14, 1.72) in triglycerides (TG), were associated with 10 μg/m3 increase in PM2.5 at the lag 0–72 h, which represent the main effects of GBA. This study indicated the link between PM2.5 and the microbiota GBA for the first time, providing evidence of the potential mechanism for PM2.5 with neurological and cardiovascular system dysfunction.

PurposeTo predict the fundus tessellation (FT) severity with machine learning methods.MethodsA population-based cross-sectional study with 3,468 individuals (mean age of 64.6 ± 9.8 years) based on Beijing Eye Study 2011. Participants underwent detailed ophthalmic examinations including fundus images. Five machine learning methods including ordinal logistic regression, ordinal probit regression, ordinal log-gamma regression, ordinal forest and neural network were used.Main Outcome MeasureFT precision, recall, F1-score, weighted-average F1-score and AUC value.ResultsObserved from the in-sample fitting performance, the optimal model was ordinal forest, which had correct classification rate (precision) of 81.28%, while 34.75, 93.73, 70.03, and 24.82% in each classified group by FT severity. The AUC value was 0.7249. And the F1-score was 65.05%, weighted-average F1-score was 79.64% on the whole dataset. For out-of-sample prediction performance, the optimal model was ordinal logistic regression, which had precision of 77.12% on the validation dataset, while 19.57, 92.68, 64.74, and 6.76% in each classified group by FT severity. The AUC value was 0.7187. The classification accuracy of light FT group was the highest, while that of severe FT group was the lowest. And the F1-score was 54.46%, weighted-average F1-score was 74.19% on the whole dataset.ConclusionsThe ordinal forest and ordinal logistic regression model had the strong prediction in-sample and out-sample performance, respectively. The threshold ranges of the ordinal forest model for no FT and light, moderate, severe FT were [0, 0.3078], [0.3078, 0.3347], [0.3347, 0.4048], [0.4048, 1], respectively. Likewise, the threshold ranges of ordinal logistic regression model were ≤ 3.7389, [3.7389, 10.5053], [10.5053, 13.9323], > 13.9323. These results can be applied to guide clinical fundus disease screening and FT severity assessment.

BackgroundCause-specific prevalence data of vision loss and blindness is fundamental for making public health policies and is essential for prioritizing scientific advances and industry research.MethodsCause-specific vision loss data from the Global Health Data Exchange was used. The burden of vision loss was measured by prevalence and years lived with disability (YLDs).FindingsIn 2019, uncorrected refractory error and cataract were the most common causes for vision loss and blindness globally. Women have higher rates of cataract, age-related macular degeneration (AMD), and diabetic retinopathy (DR) than men. In the past 30 years, the prevalence of moderate/severe vision loss and blindness due to neonatal disorders has increased by 13.73 and 33.53%, respectively. Retinopathy of prematurity (ROP) is the major cause of neonatal disorders related vision loss. In 2019, ROP caused 101.6 thousand [95% uncertainty intervals (UI) 77.5–128.2] cases of vision impairment, including 49.1 thousand (95% UI 28.1–75.1) moderate vision loss, 27.5 thousand (95% UI 19.3–36.60) severe vision loss and, 25.0 thousand (95% UI 14.6–35.8) blindness. The prevalence of new-onset ROP in Africa and East Asia was significantly higher than other regions. Variation of preterm birth prevalence can explain 49.8% geometry variation of ROP-related vision loss burden among 204 countries and territories. After adjusting for preterm prevalence, government health spending per total health spending (%), rather than total health spending per person, was associated with a reduced burden of ROP-related vision loss in 2019 (−0.19 YLDs for 10% increment). By 2050, prevalence of moderate, severe vision loss and blindness due to ROP is expected to reach 43.6 (95% UI 35.1–52.0), 23.2 (95% UI 19.4–27.1), 31.9 (95% UI 29.7–34.1) per 100,000 population.ConclusionThe global burden of vision loss and blindness highlights the prevalent of ROP, a major and avoidable cause for childhood vision loss. Advanced screening techniques and treatments have shown to be effective in preventing ROP-related vision loss and are urgently needed in regions with high ROP-related blindness rates, including Africa and East Asia.

For uveal melanoma (UM) patients, it is significant to establish diagnosis and prognosis evaluation systems through imaging techniques. However, imaging examinations are short of quantitative biomarkers and it is difficult to finish early diagnosis of UM. In order to discover new molecular biomarkers for the diagnosis and prognostic evaluation of UM, six circulating miRNAs (mir-132-3p, mir-21-5p, mir-34a-5p, mir-126-3p, mir-199a-3p, mir-214-3p) were chosen as candidates for independent validation. Validation of these miRNAs was performed in a cohort of 20 patients, including 10 spindle-shaped melanoma and 10 epithelioid cell melanoma, and 10 healthy donors. Then 5 patients with metastatic UM were included to validate the performance of miRNAs in advanced UM. Serum levels of miRNAs were determined using quantitative real-time PCR. We confirmed significantly higher levels of three miRNAs in serum of UM patients in comparison to healthy controls, and miR-199a-3p had the best performance (p < 0.0001; AUC = 0.985). MiR-214-3p and miR-21-5p were significantly upregulated in serum of epithelioid cell melanoma patients compared to spindle-shaped melanoma patients and miR-132-3p and, conversely, were significantly downregulated in serum of epithelioid cell melanoma patients. MiR-21-5p shows their best performance (p < 0.0001; AUC = 0.980). Both miR-199a-3p and miR-21-5p showed great performance in advanced UM. Significantly higher levels of miR-21-5p (p < 0.001) were found in serum of metastatic UM patients compared to patients with localized spindle-shaped melanoma, and significantly higher levels of miR-199a-3p (p < 0.001) were detected in serum of metastatic UM patients compared to healthy controls. Our preliminary data indicate promising diagnostic utility of circulating miR-199a-3p and promising prognostic utility of circulating miR-21-5p in both early and advanced UM patients.

Objective: We aimed to investigate the effect and mechanisms of action of two drug pairs [Huangqi-Chuanxiong and Sanleng-Ezhu Herb (HCSE)] on the treatment of ischemic stroke.Materials and methods: We mined the current literature related to ischemic stroke and formulated a new formulation of Chinese herbs. Then, we identified the main candidate target genes of the new formulation by network pharmacology. Next, we performed enrichment analysis of the target genes to identify the potential mechanism of action of the new formulation in the treatment of ischemic stroke. Next, we experimentally validated the mechanism of action of the new formulation against ischemic stroke. Infarct volume and neurological deficits were evaluated by 2,3,5-triphenyltetrazolium (TTC) staining and Longa’s score, respectively. The predicted pathways of signal-related proteins were detected by western blotting.Results: We mined the current literature and identified a new formulation of Chinese herbs for the treatment of ischemic stroke. The formulation included Huangqi, Chuanxiong, Sanleng and Ezhu. Next, we used network pharmacological analysis to identify 23 active compounds and 327 target genes for the new formulation. The key target genes were MAPK3, MAPK1, HSP90AA1, STAT3, PIK3R1, PIK3CA and AKT1. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed significant enrichment of the PI3K/AKT and MAPK/ERK signaling pathways. By performing experiments, we found that the new formulation reduced the infarct volume of middle cerebral artery occlusion (MCAO) induced mice and activated the PI3K/AKT and MAPK/ERK signaling pathways. These findings confirmed that the new formulation has a significant protective effect against ischemic stroke injury by activating the PI3K/AKT and MAPK/ERK signaling pathways.Conclusion: We identified a new treatment formulation for ischemic stroke by data mining and network pharmacological target prediction. The beneficial effects of the new formulation act by regulating multiple target genes and pathways. The mechanism of action of the new formulation may be related to the AKT and ERK signaling pathways. Our findings provide a theoretical basis for the effects of the new formulation on ischemic stroke injury.

Coronary artery calcium (CAC) scans contain valuable information beyond the Agatston Score which is currently reported for predicting coronary heart disease (CHD) only. We examined whether new artificial intelligence (AI) applied to CAC scans can predict non-CHD events, including heart failure, atrial fibrillation, and stroke. We applied AI-enabled automated cardiac chambers volumetry and calcified plaque characterization to CAC scans (AI-CAC) of 5830 asymptomatic individuals (52.2% women, age 61.7 ± 10.2 years) in the multi-ethnic study of atherosclerosis during 15 years of follow-up, 1773 CVD events accrued. The AUC at 1-, 5-, 10-, and 15-year follow-up for AI-CAC vs. Agatston score was (0.784 vs. 0.701), (0.771 vs. 0.709), (0.789 vs. 0.712) and (0.816 vs. 0.729) (p

BACKGROUND The large-scale mining of ion-type rare earth mines in southern Jiangxi and the unreasonable disposal of tailings and slag caused heavy metal lead content to be deposited in the surrounding environment of the mining area, exceeding the standard level, and destroying the ecological environment of the mining area. OBJECTIVES To passivate the lead in the soil of the mining area to reduce its bioavailability and ecological risks. METHODS Natural and modified attapulgite with different dosages (mass fractions of 5%, 10%, and 15%) were used as passivating agents. Scanning electron microscopy and Fourier infrared were used to analyze the surface characteristics and functional groups of the two passivating agents. Passivation ability and effect were evaluated by BCR continuous extraction method of heavy metals, and form changes of lead in the soil were also studied by this method. Environmental quality of heavy metal contaminated soil was also evaluated using foreign heavy metal TCLP extraction methods. RESULTS After 50 days of cultivation, the modified attapulgite reduced the acid-extracted content of lead from 25.69 to 7.42mg/kg, the residual content increased by 1.38 times and the TCLP extracted content decreased by 65.70% compared to the control group, significantly reducing the bioavailability and ecological risk from lead. CONCLUSIONS Compared with the natural attapulgite, the modified attapulgite has a better effect on the soil remediation of rare earth tailings.

This study evaluates the performance of the Grid-point Atmospheric Model of IAP LASG, version 3 (GAMIL3), in simulating the Madden–Julian Oscillation (MJO), based on the CMIP6 (phase 6 of the Coupled Model Intercomparison Project) AMIP (Atmospheric Model Intercomparison Project) simulation. Results show that GAMIL3 reasonably captures the main features of the MJO, such as the eastward-propagating signal in the MJO frequency band, the symmetric and asymmetric structures of the MJO, several convectively coupled equatorial waves, and the MJO life cycle. However, GAMIL3 underestimates the MJO amplitude, especially for outgoing longwave radiation, as do most CMIP5 models, and simulates slow eastward propagation.

Abstract Background Ureteric stricture is a common and salvaging complications after renal transplantation. Two treatment methods are usually used, retrograde ureteral stent placement and percutaneous nephrostomy. The former has a higher failure rate, the latter has a great risk. Therefore, a safe and reliable treatment is needed. Case presentation A technique of retrograde insertion of ureteral stent was established, which was applicable in three transplant recipients with post-transplant ureteral stenosis, and the data was retrospectively recorded. The patients are 2 men and 1 woman, ages 44, 27 and 32 years. These patients underwent a total of five times of retrograde insertion of ureteral stent between 2018 and 2019. None of these patients had any postoperative complication, but all patients had complete recovery from oliguric status within two weeks. Conclusions The retrograde ureteric stent insertion by percutaneous suprapubic access to the bladder (RUS-PSAB) was demonstrated feasibility and safety in a case series with short-term follow-up. However, larger prospective studies are needed.

Active flow control for drag reduction in turbulent boundary layer is a hot research field nowadays. In order to explore the effect of the synthetic jet through a spanwise slot on the friction drag reduction of the turbulent boundary layer of a flat plate, the streamwise velocity are measured by a constant temperature hot-wire anemometer with and without synthetic jet. According to the measured experiment data, the mean velocity profiles, fluctuating velocity profiles, skewness and flatness are obtained respectively. Typical combinations of different frequencies and intensities of synthetic jet are selected to study the variation of the forcing effect in the streamwise direction. The experimental results show that the skin friction drag reduction in the turbulent boundary layer is related to the characteristics of the imposed synthetic jet and the distance between the local station and the slot. The synthetic jet leads to an increase of the skin friction drag in the station close to the slot, and as the flow moved downstream away from the slot, a reduction in the skin friction occurred with the tendency of firstly increasing and then decreasing. The reduction of skin friction caused by the synthetic jet of a higher frequency is more than that of a lower frequency. The power spectral density and autocorrelation of the fluctuating velocities indicate that the effect of the synthetic jet on the turbulent boundary layer decays in the streamwise direction.

To investigate the effect and medical imaging of modified hemispherectomy on patients with infantile hemiparesis and medically refractory epilepsy.

Abstract Background Pediatric COVID-19 is relatively mild and may vary from that in adults. This study was to investigate the epidemic, clinical, and imaging features of pediatric COVID-19 pneumonia for early diagnosis and treatment. Methods Forty-one children infected with COVID-19 were analyzed in the epidemic, clinical and imaging data. Results Among 30 children with mild COVID-19, seven had no symptoms, fifteen had low or mediate fever, and eight presented with cough, nasal congestion, diarrhea, headache, or fatigue. Among eleven children with moderate COVID-19, nine presented with low or mediate fever, accompanied with cough and runny nose, and two had no symptoms. Significantly (P

6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine is a national class I innovative antiepileptic drug candidate in clinical trials with independent intellectual property rights. The 1H, 13C and 15N NMR spectra of the compound were acquired at 500 MHz. Aided by GIAO (Gauge-Independent Atomic Orbital)-NMR quantum chemistry calculation, the chemical shifts of the compound were assigned, providing elaborate structural information of the compound. Linear regression comparison results showed good consistency between the theoretical predictions and the experimental data for structural elucidations.

Lung cancer is a lethal malignancy. Plenty of circular RNAs (circRNAs) have been identified to be the vital regulators in lung cancer development. Here, we intended to clarify the functional role of circRNA HIPK3 (circHIPK3, also called hsa_circ_0021593) and its underlying mechanism of action. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was employed to evaluate the levels of circHIPK3 and miR-381-3p. Cell viability and apoptosis rate were monitored by Cell Counting Kit-8 assay and flow cytometry, respectively. Cell migration was estimated through the Transwell assay. To assess glycolysis, commercial kits were utilized to measure the levels of glucose and lactate and the enzyme activity of hexokinase-2 (HK2). Expression of related proteins was detected via western blot analysis. The target connection between circHIPK3 and miR-381-3p was validated by dual-luciferase reporter, RIP, and pull-down assays. The role of circHIPK3 in vivo was determined via the xenograft assay. CircHIPK3 was upregulated, while miR-381-3p was downregulated in lung cancer tissues and cells. And circHIPK3 deficiency inhibited lung cancer progression by lowering cell proliferation, migration, glycolysis, and promoting apoptosis of lung cancer cells in vitro. MiR-381-3p was a target of circHIPK3, and miR-381-3p interference alleviated circHIPK3 knockdown-induced lung cancer progression inhibition. CircHIPK3 could activate the protein kinase B/mammalian target of rapamycin (AKT/mTOR) signaling pathway. Moreover, circHIPK3 knockdown suppressed tumor growth in vivo by inactivating the AKT/mTOR signaling pathway. In conclusion, the silencing of circHIPK3 inhibited lung cancer progression, at least in part, by sponging miR-381-3p and inactivating the AKT/mTOR signaling pathway.

Abstract Background Clostridioides (formerly Clostridium) difficile infection is the leading cause of antibiotic-associated colitis. Studies have demonstrated that C. difficile toxin A (TcdA) can cause apoptosis of many human cell types. The purpose of this study was to investigate the relationships among exposure to TcdA, the role of the receptor for the globular heads of C1q (gC1qR) gene and the underlying intracellular apoptotic mechanism in human colonic epithelial cells (NCM 460). In this study, gC1qR expression was examined using real-time polymerase chain reaction (PCR), western blotting and immunohistochemical staining. Cell viability was assessed by the water-soluble tetrazolium salt (WST-1) assay, and cell apoptosis was assessed by flow cytometry and the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay. Mitochondrial function was assessed based on reactive oxygen species (ROS) generation, changes in the mitochondrial membrane potential (ΔΨm) and the content of ATP. Results Our study demonstrated that increasing the concentration of TcdA from 10 ng/ml to 20 ng/ml inhibited cell viability and induced cell apoptosis (p

Abstract Background The goal of this review is to summarize structural and anatomical changes associated with high myopia. Main text Axial elongation in myopic eyes is associated with retinal thinning and a reduced density of retinal pigment epithelium (RPE) cells in the equatorial region. Thickness of the retina and choriocapillaris and RPE cell density in the macula are independent of axial length. Choroidal and scleral thickness decrease with longer axial length in the posterior hemisphere of the eye, most marked at the posterior pole. In any eye region, thickness of Bruch’s membrane (BM) is independent of axial length. BM opening, as the inner layer of the optic nerve head layers, is shifted in temporal direction in moderately elongated eyes (axial length 26.5 mm), BM opening enlarges with longer axial length. It leads to a circular gamma zone. In a parallel manner, the peripapillary scleral flange and the lamina cribrosa get longer and thinner with longer axial length in highly myopic eyes. The elongated peripapillary scleral flange forms the equivalent of parapapillary delta zone, and the elongated lamina cribrosa is the equivalent of the myopic secondary macrodisc. The prevalence of BM defects in the macular region increases with longer axial length in highly myopic eyes. Scleral staphylomas are characterized by marked scleral thinning and spatially correlated BM defects, while thickness and density of the choriocapillaris, RPE and BM do not differ markedly between staphylomatous versus non-staphylomatous eyes in the respective regions. Conclusions High axial myopia is associated with a thinning of the sclera and choroid posteriorly and thinning of the retina and RPE density in the equatorial region, while BM thickness is independent of axial length. The histological changes may point towards BM having a role in the process of axial elongation.

Because of its light weight, high strength, designable, composite materials are more and more widely used in the field of aerospace, especially in the field of general aviation. In this paper, the structural design and analysis of the composite wing (include wing beam, rib, skin, leading edge and trailing edge) of a four-seater electric aircraft were carried out. The finite element numerical analysis model of the composite wing was established, and the deformation and strain distribution of the composite wing under the limited load required by airworthiness regulations were calculated. Finally, the static test of the whole composite wing was carried out to verify the accuracy of the finite element results. The finite element analysis and testing results showed that the structural design of the composite wing of the electric aircraft meets the structural strength requirements specified in the airworthiness standard (part 23 of China civil aviation regulations: air-worthiness requirements for normal, practical, special effects and commuting aircraft: CCAR 23-R3)

Abstract Background Intraocular pressure (IOP) is an important physiological measure of the eye and is associated with some ocular disorders. We aimed to assess the influence of topical beta blocker-induced IOP reduction on lens-induced axial elongation in young guinea pigs. Methods The experimental study included 20 pigmented guinea pigs (age: 2–3 weeks). Myopia was induced in the right eyes for 5 weeks with − 10 diopter lenses. The right eyes additionally received either one drop of carteolol 2% (study group, n = 10) or one drop of artificial tears daily (control group, n = 10), while the contralateral eyes of all animals remained untouched. The outcome parameter was axial elongation during the follow-up period. The mean of all IOP measurements taken during the study was referred to as mean IOP. Results Greater axial elongation was associated with a shorter axial length at baseline (P 0.25). Conclusions In young guinea pigs with or without lens-induced axial elongation, neither the physiological IOP nor the IOP reduced by carteolol, a topical beta-blocker, was associated with the magnitude of axial elongation. These results suggest that IOP, regardless of whether it is influenced by carteolol, does not play a major role in axial elongation in young guinea pigs.

Abstract Understanding existing fractures is critical to achieving high and stable yields in low‐permeability reservoirs, tight sandstones, and shale reservoirs. When multiple fracture sets are present in a reservoir, accurately determining the seepage direction of fluids is critical for the deployment of the well network, fracture reformation, and the design of horizontal wells. In this paper, based on conventional logging data calculations and rock triaxial mechanical experiments, a heterogeneous finite element model was established using the finite element software. The densities and the occurrence of the natural fractures were calculated by numerical simulation of the paleostress field; the fracture apertures were calculated numerically by a current in situ stress simulation. Using a combined static coordinate system and dynamic coordinate system approach, a model suitable for determining the 3D permeability tensor of multiple fractures is established, and the formula of the permeability tensor is given. In addition, by adjusting the rotation angle and flip angle in the dynamic coordinate system, the permeability of elements is predicted for different directions. The results show that fractures mainly trend in the NE (45°) and ESE (120°) directions. Additionally, the results of differential strain, microseismic monitoring, stress relief, and regional borehole collapse observations indicate that the dominant direction of the in situ stress field is ENE (70°). The principal values of maximum permeability in the reservoirs in the Chang 71 layer mainly range from 0.05 to 2 × 10−3 μm2, and in the horizontal plane, the direction of maximum principal permeability ranges from 56 to 124°.

[Objectives] The radome is necessary equipment for the stealth design of radars in modern surface ships. To ensure that the rotation and transmitting performance of the radar in the radome are not affected,the thermal environment needs to be controlled. However,traditional air-conditioning and ventilation modes cannot meet the requirements. Therefore,a new kind of air-conditioning and ventilation mode for an enclosed radome is proposed.[Methods] This new air-conditioning and ventilation mode involves the cavity of the radar base being used as the plenum for the air supply,in which the air-conditioning duct is connected to the radar base and the air supply outlet is located there. In order to verify the effectiveness of this method,a physical and numerical calculation model was established for an experimental enclosed radome,and the simulation and testing of heat distribution were carried out for the air-conditioning effects in the radome.[Results] After adopting the radar base air-conditioning and ventilation mode,the temperature of the radome met the design requirements,and the temperature distribution was uniform.[Conclusions] The proposed radar base air-conditioning and ventilation mode can fully satisfy the environmental control requirements in an enclosed radome,making it suitable for application in the stealth design of surface ships.

Abstract Background Patients with locally advanced colon cancer (LACC) treated with surgery had a high risk of local recurrence. The outcomes can vary significantly among patients with pT3 disease. This study was undertaken to assess whether low-kilovolt (kV) x-ray intraoperative radiotherapy (IORT) can achieve promising results compared with electron beam IORT (IOERT) and whether specific subgroups of patients with pT3 colon cancer may benefit from low-kV x-ray IORT. Methods We retrospectively reviewed 44 patients with pT3 LACC treated with low-kV x-ray IORT. Clinicopathologic characteristics were analyzed to identify patients that could potentially benefit from low-kV x-ray IORT. The Kaplan-Meier survival analysis was used to assess overall survival (OS) and progression-free survival (PFS). Correlation analysis was used to discover the association of multiple factors to the results of treatment represented by the values of OS and PFS. Results The median follow-up of patients was 20.5 months (range, 6.1–38.8 months). At the time of analysis, 38 (86%) were alive and 6 (14%) had died of their disease. The 3-year Kaplan-Meier of PFS and OS for the entire cohort was 82.8% and 82.1%, respectively. At median follow-up, no in-field failure within the low-kV x-ray IORT field had occurred. Locoregional and distant failure had occurred in 2 (5%) patients each. The rate of perioperative 30-day mortality was 0%, and the morbidity rate was 11%. Five patients experienced 7 complications, including 4 early complications (30 days) and three late complications (> 30 days) leading early and late morbidity rates of 9% and 7%, respectively. Conclusion Patients with LACC who had undergone an additional low-kV x-ray IORT can achieve encouraging locoregional control, PFS, OS, and distant control without an increase in short-term or long-term complications. Low-kV x-ray IORT can be considered as part of management in pT3 LACC.

The relationship between temperature-pressure-adsorption of raw coal and deformed coal of Daning Coal Mine is calculated by using a series of isotherm adsorption experimental data. The results show that the adsorption process is an exothermic process. The isosteric enthalpy of adsorption, the unit isosteric enthalpy of adsorption, and the unit isosteric enthalpy of desorption are defined. When the adsorption capacity is 45 cm3/g, the unit isosteric heat of desorption of deformed coal is 0.158 kJ/(mol·cm3·g) less than that of raw coal. Compared with the normal coal, the deformed coal is preferred to desorption; compared with the exothermic process, the buried depth strengthens the desorption; compared with the raw coal, the deformed coal is easier to extract the necessary energy for desorption from the environment. Compared with raw coal, the low permeability and low firmness coefficient of deformed coal are more likely to lead to coal and gas outburst.

In view of structural faults that occurred during operation of linear vibrating screen in coal preparation plant, the method combining finite element simulation and field test was used to analyze and study the cause of faults of vibrating screen. The main structure and common faults of vibrating screen are introduced, taking the vibrating screen with beam fracture in a coal preparation plant as an example, three-dimensional modeling and finite element modal analysis are carried out on the vibrating screen. Analysis results show that with the increase of the mode order, the change of the vibration shape gradually changes from the movement to distortion of the structure itself. Vibration test by intrinsically safe portable vibration measuring recorder is performed on the vibrating screen under no-load working state and the test signal is processed to obtain working frequency of the vibrating screen. Combined with the modal analysis results and the actual test results, it is concluded that frequent operation of the vibrating screen during no-load is the main reason for beam fracture. Maintenance suggestions are given according to the fault cause: the vibrating screen should be avoided to run for a long time under the condition of no load or less material; before the vibrating screen is put into use, the working state and possible weak links of the vibrating screen should be known in advance to avoid structural fault as much as possible and to ensure the reliable operation of the vibrating screen.

Abstract Background The use of electronic cigarettes (ECIGs) is increasing, but the impact of ECIG-vapor on cellular processes like inflammation or host defense are less understood. The aim of the present study was to compare the acute effects of traditional cigarettes (TCIGs) and ECIG-exposure on host defense, inflammation, and cellular activation of cell lines and primary differentiated human airway epithelial cells (pHBE). Methods We exposed pHBEs and several cell lines to TCIG-smoke or ECIG-vapor. Epithelial host defense and barrier integrity were determined. The transcriptome of airway epithelial cells was compared by gene expression array analysis. Gene interaction networks were constructed and differential gene expression over all groups analyzed. The expression of several candidate genes was validated by qRT-PCR. Results Bacterial killing, barrier integrity and the expression of antimicrobial peptides were not affected by ECIG-vapor compared to control samples. In contrast, TCIGs negatively affected host defense and reduced barrier integrity in a significant way. Furthermore ECIG-exposure significantly induced IL-8 secretion from Calu-3 cells but had no effect on NCI-H292 or primary cells. The gene expression based on array analysis distinguished TCIG-exposed cells from ECIG and room air-exposed samples. Conclusion The transcriptome patterns of host defense and inflammatory genes are significantly distinct between ECIG-exposed and TCIG-treated cells. The overall effects of ECIGs on epithelial cells are less in comparison to TCIG, and ECIG-vapor does not affect host defense. Nevertheless, although acute exposure to ECIG-vapor induces inflammation, and the expression of S100 proteins, long term in vivo data is needed to evaluate the chronic effects of ECIG use.

Syndrome-Trellis Codes (STC), as the de facto state-of-the-art steganography framework, has drawn huge attention recently. However, the original STC merely developed with the general form of cover and message, and almost all the subsequent improvements for STC focused on the cover selection and design of the distortion cost function. How to select the optimal submatrix by the features for the given cover and message is an important issue and requires to be solved urgently. In this work, we propose to divide both the cover and message into segments and embed each message segment into its optimally matched cover segment. We name the proposed method as Segment-STC steganography. Specifically, by investigating the features of the submatrix used in STC, we first select the optimal submatrix, which could effectively reduce the number of distorted elements during the embedding. Then, the given cover and message will be split into a series of segments. Each message segment is adaptively matched with an optimal submatrix. We conduct the experiments on both the benchmark BOSS dataset and our collected on-line songs dataset. The experimental results show that, compared with the original STC, our method could effectively reduce the distortion and improve the undetectability of the stego.

Although neural network-based speech recognition models have enjoyed significant success in many acoustic systems, they are susceptible to be attacked by the adversarial examples. In this work, we make first step towards using generative adversarial network (GAN) for constructing the targeted speech adversarial examples. Specifically, we integrate the target speech recognition network with GAN framework, which can then be formulated as a three-party game. The generator in GAN aims at generating perturbation that could make the target network misclassified to a specific target, while simultaneously fooling the discriminator treating the adversarial example as a beguine one. The discriminator is to distinguish the crafted examples from the geniue samples. The classification error of the target network is back-propagated via gradient flow to the generator for updating. The target network is responsible for back-propagating the classification error via gradients to the generator for updating, but the target network itself is freezed. With the carefully designed network architecture, loss function and training strategy, we successfully train a generator that could generate the adversarial perturbation for a given speech clip and a target label. Experiential results show that the generated adversarial examples could effectively fool the state-of-the-art speech classification networks, while attaining an acceptable auditory perception quality. In addition, our proposed method runs much faster than the prevalent optimization-based schemes. To facilitate reproducible research, codes, models and data are publicly available at https://github.com/winterwindwang/SpeechAdvGan.

The radar monitor of aircraft wake vortex is of great significance to air traffic control. Comparing with the case in clear air, the radar signal of wake vortices in rainy conditions is more easily captured due to the higher levels of signal. To able to analyze radar echo characteristics of evolving wake vortices, the numerical simulation of the evolution of the wake vortices in various rain rates has been performed based on the Euler-Euler frame. The result shows that the rainfall can accelerate the decay of wake vortices. A radar simulator has been represented to process the radar echo signal of raindrops around the wake vortex. The Doppler spectrum of echo signals in radar resolution volumes has been analyzed and the straight vortex and the vortex ring phases show different characteristics of spectrum width. The Doppler width information based on this result of interaction between the wake vortex and rain can be used for assessing the decay phase of wake vortices and monitoring potential hazard for wake vortex encounters.

In recent years, the reversible data hiding (RDH) based on dual stego cover is developing rapidly because of its high capacity and low distortion. For image case, however, two consecutive images of the same image will draw the attention of adversaries during transmission. In this article, we propose a high-capacity RDH scheme using dual-channel audio, by exploiting the natural dual-channel property of the stereo audio. Specifically, we first convert secret message into novenary digits, which could increase the embedding capacity. Then, the magic matrix is used to embed the secret digit into a single-channel audio to generate two single-channel stego-audio. Finally, the two single-channel stego-audio is combined as a convention dual-channel audio. Extensive experiments have demonstrated that our proposed method could significantly boost the stego quality (the SNR is improved by 16% on average), when comparing with the state-of-the-art methods.