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International audience; In this article we present recent work towards the development of an autonomous system with point merge (PM) that performs sequencing, merging and spacing for arrival aircraft in the busy terminal area. This autonomous arrival management system aims to safely solve the major arrival flight scheduling problems currently handled by human controllers. With PM, it has the potential to handle higher traffic demands without more workload on controllers, consequently increasing capacity and reducing delay. The main objective of this paper is to introduce the framework of this autonomous system with PM. Based on analysis of classic PM route structure, a novel PM-based route network is firstly designed for Beijing Capital International Airport. Vertically, this PM system consists of multi-layers on the sequencing legs for different categories of aircraft with Heavy and Medium, horizontally, it is shaped as a lazy “8”. Then, a multiple-objectives function is discussed for this aircraft scheduling problem, operational constraints and conflict detection and resolution are analysed in detail, a modelling strategy with sliding time window and simulated annealing algorithm is proposed for solving this real-time dynamic problem. Experimental results verify our algorithm is well adapting the high-density traffic optimisation, and finally a conclusion is made and future work is pointed out

At room temperature, single-crystal ZnO was implanted with Co ions at an energy of 80 keV using fluence of 1 x 10(17) ions.cm(-2). The samples were heat treated by conventional thermal annealing at 700 degrees C for 10 min. The structural properties were investigated of all samples by means of X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Extended X-ray absorption fine structure (EXAFS). XRD analysis indicates that there are Co or CoO nanoparticles in the samples before and after annealed. The peak of ZnO(002) shifts to larger angle presumably results from the Co(2+) ions substituting for a part of Zn(2+) ions in the ZnO lattice. Ion implantation without changing the lattice structure of ZnO. The XPS results indicate that Co element in the ZnO mainly exists in the form of Co(2+), the reason may be that Co ions combine with O element in ZnO as oxide or Co ions substitute for Zn(2+) sites in the ZnO. EXAFS analyses provide that Co ions mainly exist as Co nanoparticles in the samples.

Spinal cord injured rat model, treated with soluble complement receptor type 1 (sCR1). Experimental Animal Department of China Medical University, Shenyang, China. Soluble CR1 is a powerful inhibitor of complement activation. In this study, we investigate the effectiveness of sCR1 on spinal cord injury (SCI) in rats. Spinal cord injury was induced in Sprague–Dawley rats. Three experimental groups were examined; the sCR1 group was administered sCR1 at 1 h after the SCI, whereas the control group was administered saline at 1 h after SCI and the sham group underwent a sham operation without SCI or administration. The expressions of C9 and CD59 in the injured spinal cords were evaluated by immunohistochemistry, and numbers of positive cells counted. Furthermore, myeloperoxidase (MPO) activity and motor function were evaluated in each group. At all postoperative time points, the numbers of C9- and CD59-positive cells in the sCR1 group were reduced compared with the control group and MPO activity was significantly decreased compared with both other groups. Moreover, the Basso, Beattie and Bresnahan score for the sCR1 group was significantly improved as compared with that of the control group after 7 days postoperatively. Soluble CR1 decreases inflammation reactions by inhibiting activation of the complement system and improves motor function after acute SCI.

The activation of complement system has been known as an important and significant reaction against the secondary injury after spinal cord injury (SCI). In the present study, we investigated the effect of Ephedra sinica to the inflammation or complement system of injured spinal cord and the influence to the functional recovery after spinal cord injury in rats. We prepared the complement-inhibiting component from E. sinica. Contusive spinal cord injury was induced to Sprague-Dawley rats. We administrated the product from E. sinica to E. sinica group, while distilled water was administered to the control group by gavage after SCI. Complement hemolytic activity (CH50), expression of C3 and C9, myeloperoxidase activity, and motor function were evaluated in E. sinica group and control group. The CH50, complement depositions, and myeloperoxidase activity in the E. sinica group were significantly reduced as compared to the control group. The motor function of E. sinica group was significantly improved from the 7th day as compared with the control group. The results demonstrated that E. sinica might reduce inflammation and improve motor function in rats after spinal cord injury by inhibiting complement activation. The present study has shown that complement system is playing an important role in spinal cord injury, and the possibility of a new therapy strategy, inhibiting or controlling the complement activation and inflammation, for spinal cord injury.

International audience; This paper reports on the research status of automated merging 4D trajectories for multi-parallel runwaysoperations in complex terminal area. In order to simultaneously reduce delay and increase capacity in metropolis airportwith multi-parallel runways, based on the classic Point-Merge route structure, a novel Multiple-Points-Merge (M-PM)route system is firstly proposed. It consists of multi-layers on the sequencing legs for dierent categories of aircraftwith H,Mand L, and a M-PM system for Beijing Capital international airport is built with lazy “8” topology. After that,a multiple-objectives function is discussed for this aircraft scheduling problem, operational constraints are analyzed indetail, a modelling strategy with sliding time window and simulated annealing algorithm is proposed for solving thisreal-time scheduling and sequencing landing problem. According to the relationship between aircraft entry time andthe position of sliding time window, all arrival aircraft are firstly classified into 4 dierent status: planned, ongoing,active, and completed, and then in the sliding time window the aircraft with active or ongoing status are optimized withre-sequence and conflict detection and resolution (CD&R) process. Conflict detection (CD) is based on pairwise formto detect separation infringement between aircraft. There are two types of conflict, catching up conflict and convergingconflict. Conflict resolution (CR) solve the detected horizontal conflict with speed adjustment, slot time control, andturning time control technique. In a future work, this novel M-PM system will be evaluated with real operational data.

PM10 and PM2.5 aerosol particle samples were collected at a subway station in Shanghai and their morphology, chemical composition and transition metal species were studied. The mass concentrations of PM10 and PM2.5 inside the subway station were significantly higher than those measured in aboveground ambient air. The PM levels inside subway were much higher than the state control limit. The aerosol composition in the metro station was quite different from that of the aboveground urban particles. Concentrations of Fe, Mn and Cr were higher than the averages of aboveground urban air particles by factors of 8, 2, and 2, respectively, showing a substantial enrichment in subway. Scanning electron microscope (SEM) analysis showed that the subway particles had flat surfaces in combination with parallel scratches and sharp edges and looked like metal sheets or flakes. Furthermore, analysis of the atomic composition of typical subway particles by energy dispersive X-Ray (EDX) spectroscopy showed that oxygen and iron dominated the mass of the particles. The X-ray absorption near-edge structure (XANES) spectroscopy results showed that a fraction (26%) of the total iron in the PM10 was in the form of pure Fe, while in the street particles Fe(III) was shown to be a significant fraction of the total iron. The work demonstrated that the underground subway stations in Shanghai were an important microenvironment for exposure to transition metal aerosol for the people taking subway train for commuting every day and those who work in the subway stations, and the metal particle exposure for people in the subway station should not be ignored.

Remarkable room-temperature ferromagnetism was observed both in undoped and Cu-doped rutile TiO2 single crystals (SCs). To tune their magnetism, Ar ion irradiation was quantitatively performed on the two crystals in which the saturation magnetizations for the samples were enhanced distinctively. The post-irradiation led to a spongelike layer in the near surface of the Cu-doped TiO2. Meanwhile, a new CuO-like species present in the sample was found to be dissolved after the post-irradiation. Analyzing the magnetization data unambiguously reveals that the experimentally observed ferromagnetism is related to the intrinsic defects rather than the exotic Cu ions, while these ions are directly involved in boosting the absorption in the visible region.

To investigate the effects of complement inhibiting component of Ephedra sinica on immunological inflammation following acute spinal cord injury (SCI) in rats.The complement inhibiting component of Ephedra sinica was isolated by multiple precipitation steps and thin layer chromatography, and then the activity was analyzed. Fifty healthy SD rats were selected and randomly divided into the control group and the experimental group, 25 in each group. Induction of SCI was performed following a modified Allen's weight-drop method. The complement inhibiting component from Ephedra sinica (15 mg/kg) dissolving in 5 mL normal saline was immediately administered by gastrogavage after SCI, once daily. Equal volume of normal saline was administered to rats in the control group by gastrogavage. Hematoxylin and eosin (HE) staining and C3 immunohistochemical staining were performed in SCI tissue at 12 h, day 1, 3, 7, and 14 after SCI. C3 positive expressions and myeloperoxidase (MPO) activity were assessed. Intercellular adhesion molecule-1 (ICAM-1) mRNA expression level was evaluated by Real-time PCR technique.C3 positive expression, MPO activity, and ICAM-1 mRNA level were significantly weaker in the Ephedra sinica group than in the control group at all time points (12 h, day 1, day 3, day 7, and day 14 after SCI) (P0.01, P0.05).There existed complement system activation following acute SCI. The complement inhibiting component of Ephedra sinica significantly reduced immunological inflammation after SCI, and played an important role in secondary SCI.

The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase and CBM databases. Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2 software. From these data, the odds ratio (OR) with 95% confidence interval (CI) was calculated. Finally, 8 case-control studies were retrieved reporting a total of 2,131 gastrointestinal cancer patients and 2,670 controls. Meta-analysis results showed that there was no significant association between the VEGF +936C/T polymorphism and GC risk in all comparisons of the T allele vs. C allele (OR=1.08, 95% CI 0.90-1.30, P=0.42), CT+TT vs. CC (OR=1.08, 95% CI 0.87-1.34, P=0.49), TT vs. CC+CT (OR=1.14, 95% CI 0.85-1.53, P=0.37), TT vs. CC (OR=1.18, 95% CI 0.87-1.59, P=0.28) and TT vs. CT (OR=1.11, 95% CI 0.79-1.56, P=0.56). This meta-analysis confirms that there is a lack of association between the VEGF +936C/T polymorphism and GC risk.

Haplocladium was cultivated in a special prepared nutrient medium containing different concentrations of Pb, Fe and Cr in laboratory. The sulfur content in moss was measured by synchrotron radiation X-ray fluorescence (SRXRF), and the percentage of various oxidation states of sulfur was analyzed by X-ray absorption near-edge structure (XANES) spectrum. The results show that the sulfur absorption increases under exposure to heavy metal ions of Pb and Fe, but it decreases under exposure to 400 mg/L Pb and 200 mg/L Fe. When Haplocladium was cultivated for 15 days, under the stress of 100 mg/L Pb, the relative content of low oxidation states sulfur increases from 17.8% to 23.6% and the sulfate sulfur decreases from 56.3% to 51.2%. Under the stress of 400 mg/L Pb, the relative content of low oxidation state sulfur increases from 17.8% to 24.8%, and the sulfate sulfur decreases from 56.3% to 48.4%. Under heavy metal exposure, the total relative content of low oxidation states sulfur such as cystine, cysteine, methionine and glutathione increases, and the relative content of sulfate sulfur apparently decreases. All these results indicate that the changing characteristics of sulfur content and oxidation states percentage in sulfur assimilation process under heavy metal exposure can be used as a bioindicator of heavy metal pollution.

The elemental size distributions of airborne fine/ultrafine particulate matters in the suburb of Shanghai were studied using synchrotron X-ray fluorescence. Median mass aerodynamic diameter (MMAD), elemental correlation coefficient as well as enrichment factor (EF) of each size fraction were calculated to characterize the sources of elements in fine/ultrafine particulate matters. Ca and Ti distributed mainly in coarse particles (2 microm) with size independent enrichment factors between 0.1 and 3.2, and the correlation coefficient between Ca and Ti was as high as 0.933, which implied strong contribution from nature sources, such as soil dusts and resuspended dusts. However, V, Cr, Mn, Ni, Zn, Cu, Pb, Cl, S mainly distributed in 0.1-1.0 microm particulate matters with MMAD between 0.56-0.94 microm. The EF of V, Cr, Ni, Cu, Zn, Pb increased with decreasing particle size. The highest EF were found for Pb in ultrafine particulate matters (0.1 microm) with EF of 2,023.7-2,244.2. The evidences suggested that these elements were significantly influenced by anthropogenic sources and enriched in fine/ultrafine particles smaller than 1 microm. Fe distributed uniformly in the particles larger than 0.2 microm with MMAD of 1.3 microm. The results indicated non-negligible influences of remote transmission of anthropogenic pollutions.

By using traditional sampling methods, the micro-communities of vegetations in fixed, semi-bare, and bare blowouts of Hulunbuir grassland were investigated, and the investigation data were statistical analyzed. The results showed that the vegetation coverage decreased in the order of fixed blowout, semi-bare blowout, and bare blowout, and was lower than that of the primary vegetation Form. Stipa grandis. Potentilla acaulis and Kengia squarrosa were the dominant species in fixed blowout, with the coverage being 5%; while P. acaulis and Carex sp. were the dominant species in semi-bare blowout, with the coverage being 2%. The dominant species in depositional areas of semi-bare blowout were P. acaulis, K. squarrosa, Agropyron cristatum, and Thymus mongolicus, and the coverage was 4%. The dominant species on the southwest slope of bare blowout was Agriophyllum pungens. The middle depositional area of bare blowout was also occupied by A. pungens (coverage 4.7%), and the edge of it was dominated by A. cristatum (coverage 2.7%), Carex sp. (coverage 2.6%), and T. mongolicus (coverage 1.7%) from the edge of the depositional area to primary grassland. The mean species importance value in fixed, semi-bare, and bare blowouts was 12.64%, 13.38%, and 20.08%, while that in the depositional area of semi-bare blowout and in the middle and edge of bare blowout was 12.55%, 40.18%, and 11.15%, respectively.

Current mobile network architecture is constructed through introducing mobile IP protocol on the basis of IP network. On the one hand it cannot break away from the inherent limitation of IP network, such as no strong security, complex forwarding devices, lack of high expansibility and no QoS guarantee. On the other hand it brings some new problems due to the repair to IP network, such as the triangular routing problem. A new mobile network architecture based on vector network is proposed in this paper. The design philosophy of this architecture is to separate the name address and the switching address of the mobile nodes, so it can support node mobility inherently. Besides, this architecture also possesses many innovation characteristics. For example, soft handoff can be achieved through multi-path connection to improve the handoff performance.

To determine the effects of recombinant soluble complement receptor type I (sCR1) on the immune inflammatory reaction in acute spinal cord injury tissue of rats and its protective effects.SD rat models of acute spinal cord injury were prepared by modified Allen's method. The motor function of the rat lower extremities in sCR1 group and normal saline (NS) group was evaluated by the tiltboard experiment at 12 h, 1 d, 3 d, 7 d, and 14 d. The neutrophil infiltration and C3c positive expression were observed. The myeloperoxidase activity was assessed in the injury tissue at 12 h, 1 d, 3 d, 7 d, and 14 d after injury in the two groups.The motor function of rat in sCR1 group at 3 d, 7 d, and 14 d was obviously better than that in NS group (P0.01, P0.01, P0.01). C3c positive expression in sCR1 group at each time point after injury was obviously less than that in NS group (P0.01). The myeloperoxidase activity in sCR1 group at each time point after injury was obviously less than that in NS group (P0.01).Recombinant soluble complement receptor type I (sCR1) can lessen the immune inflammatory reaction in acute spinal cord injury tissue and relieve secondary spinal cord injury by inhibiting the activation of the complement system.

Remarkable room temperature ferromagnetism in pure single-crystal rutile TiO2 (001) samples irradiated by D-D neutron has been investigated. By combining X-ray diffraction and positron annihilation lifetime, the contracted lattice has been clearly identified in irradiated TiO2, where Ti4+ ions can be easily reduced to the state of Ti3+. As there were no magnetic impurities that could contaminate the samples during the whole procedure, some Ti3+ ions reside on interstitial or substituted sites accompanied by oxygen vacancies should be responsible for the ferromagnetism.