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In this work, we report on the preparation and characterization of the planar and ridge optical waveguides in the

In this work, we report the fabrication of an optical waveguide by single-energy H+ ion implantation in the Er3+-doped phosphate glass. The ion implantation conditions are with energy of 0.4 MeV and a fluence of 8.0×1016 ions/cm2. The dark mode spectrum of the waveguide structure was measured by the prism coupling experiment. The refractive index change along with the penetration depth was fitted by using the reflectivity calculation method (RCM). Finally, the calculated near-field light intensity distribution shows superior waveguide properties, which demonstrates its promising potentials for compact optical integrated devices.

The optical planar waveguides were fabricated by proton implantation with an energy of 400 keV and a dose of 8 × 1016 ions / cm2 or 400-keV helium-ion implantation with a fluence of 6 × 1016 ions / cm2 in the fluoride lead silicate glass. The morphologies were studied by a Zeiss microscope to estimate the thickness of the waveguides. The annealing effects on the fluoride lead silicate glass waveguides were investigated by 60 min annealing cycles at different temperatures ranging from 260°C to 310°C in air atmosphere. The dark-mode spectra and corresponding effective refractive indices before and after the thermal treatments were measured by the prism coupling system. The Stopping and Range of Ions in Matter 2013 code was used to simulate the irradiation process and calculate the energy losses. The refractive index distributions were reconstructed by the reflectivity calculation method. The near-field light intensity profiles of the proton and helium-ion implanted fluoride lead silicate glass waveguides were measured by the end-face coupling system. The comparison of optical properties between the proton-implanted waveguide and helium-ion implanted one was carried out. The experimental results show that the helium-ion implantation is more suitable for the fabrication of the fluoride lead silicate glass optical waveguides and the He + -implanted waveguide has better optical propagation performances.

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Background: Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease with a high fatality rate. Up to now, there are an estimated 26 million confirmed cases and 865,000 deaths around the world. But no effective way can control this disease. As the country that first discovered and treated the COVID-19, China has formed relatively mature prevention and treatment methods such as “3 prescriptions and 3 drugs.” Xuan Fei Bai Du Fang, as a member of “3 prescriptions and 3 drugs,” has very good clinical effects Methods: The PubMed, EMBASE, ClinicalTrials.gov, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for randomized controlled studies published to date. This study only screens clinical randomized controlled trials on QFBDF for COVID-19 to evaluate its efficacy and safety. Import all literatures that meet the requirements into Endnote X9 software. The information was finally cross-checked by 2 reviewers. Papers selected for review were assessed for risk of bias according to the criteria. Quality assessment on design of study, risk of bias, indirectness and imprecision were assessed using the GRADE framework. Where sufficient studies were available, publication bias was assessed visually using funnel plots. Relative risks for primary and secondary outcomes were calculated on an intent-to-treat basis and pooled using random effects meta-analysis. the continuous is expressed by mean difference or standard mean difference, eventually the data is synthesized using a fixed effect model or a random effect model depending on whether or not heterogeneity exists. The heterogeneity of studies will be evaluated by Q-test and I2 statistic with RevMan5.3. Results: The time from a positive diagnosis to a negative result of 2 consecutive nucleic acid tests (not on the same day), cure rate. The results of our research will be published in a peer-reviewed journal. Conclusion: The purpose of this systematic review is to provide new evidence for the effectiveness and safety of Xuan Fei Bai Du Fang in the treatment of COVID-19. PROSPERO registration number: CRD42020213950.

Achalinus pingbianensis sp. nov. (Figures 1, 3–5) Holotype. YBU 18273, an adult male, collected by K. Li, M. Yu, L. H. Liao, and K. Tang at night on July 12, 2019 in Dawei Mountain Nature Reserve, Pingbian County (N 103°42′01.02″, E 22°55′02.78″), southeastern Yunnan Province, China, at an elevation of 1, 968 m above sea level. Diagnosis. A new species of Achalinus having the combination of (1) dorsal scales strongly keeled, 23 rows throughout; (2) tail relatively short, TaL/TL 24.3%; (3) length of suture between internasals subequal to that between prefrontals; (4) nasal divided into two sections by nasal cleft; (5) loreal fused with prefrontal, with the prefrontal extending towards the supralabials; (6) supralabials 7, the fifth and sixth widely in contact with eye; (7) infralabials 6, the first three touching the first pair of chin shields; (8) temporals 2+2+3 on right side and 2+2 on left side, the uppermost anterior temporal in contact with eye; (9) ventrals 164+2, subcaudals 56, arranged in single row; (10) anal entire; (11) uniform black, tinged weakly iridescent; (12) light black beneath. Description of holotype. An adult male with a total length of 429 mm (SVL 345 mm and TaL 84 mm), TaL/TL 24.3%. Body slender, cylindrical; head slightly distinct from neck; eye small, with vertically oval pupil; rostral small, triangular, slightly visible from above. LSBI subequal to LSBP. Nostril in the anterior part of the nasal, posterior margin of nostril with a distinct nostril cleft, the posterior section of nasal vertically rectangular. Frontal pentagonal, slightly broader than long, pointed backwards, much shorter than the parietals; each parietal bordered by an elongated nuchal. Nuchals separated from each other behind parietals by one small scale; the second pair of nuchals about 2/3 the size as the first pair. Loreal lacking, prefrontals stretch towards the SPL. Preocular and postocular absent. A single SPO. Two aTMP, elongated, upper one smaller, only uppermost in contact with eye, four elongated pTMP on right side, and pTMP of the left side nondescript. SPL 7, the first smallest, fifth and sixth in contact with the eye, seventh longest. One mental, followed by six IFL, the first pair of IFL in contact with each other; the first three IFL touching the first pair of chin shields; posterior pair of chin shields larger, length of the suture between the first pair equal to that between the second pair, laterally in contact with third to fifth IFL. Dorsal scales lanceolate and strongly keeled, in 23-23-23 rows, those of the most outer rows on both sides significantly enlarged and smooth. VS 164 (plus two preventrals), distinctly rounded laterally; SC 56, not paired; anal entire. Coloration of holotype in life. Uniform black above, vertebral line unseen. All scales tinged iridescent and margin of scales greyish white. Uniform light black beneath. The ventral tail dark brown, the dorsal tail surface iridescent black (Figs. 3 and 4). Coloration of holotype in preservation. All scales tinged weakly iridescent. Uniform black, margin of all scales dark grey. Etymology. The specific name refers to the type locality of this species, Dawei Mountain Nature Reserve, Pingbian County, Southeastern Yunnan, China. We suggest the common names as Ping Bian Ji She (DZṈṘẘ) in Chinese and Pingbian odd-scaled snake in English. Distribution and habits. Currently, Achalinus pingbianensis sp. nov. is known only from its type locality at Dawei Mountain Nature Reserve, Pingbian County, southeastern Yunnan Province, China (Fig. 1). The specimen was found at 9:00 PM on the road with moss and leaf litters in well-preserved montane evergreen broadleaf forest on both sides. Comparisons. Achalinus pingbianensis sp. nov. differs from all other species of Achalinus, except A. jinggangensis and A. timi, by the absence of a loreal. Achalinus pingbianensis sp. nov. further differs from A. jinggangensis, A. timi, A. ater, A. hainanus, A. rufescens, A. emilyae, A. yunkaiensis, and A. juliani by having length of suture between internasals subequal to that between prefrontals (vs. distinctly longer than that between prefrontals). Achalinus pingbianensis sp. nov. can be easily distinguished from A. formosanus (mDSR 25–27), A. meiguensis (mDSR 19–21), A. timi (mDSR 25), and A. niger (mDSR 27) by having mDSR 23, and from A. hainanus and A. meiguensis by the presence of internasals. In addition, the new species can be differentiated from some congeners in VS, SC, and Tal/TL ratio. Comparisons between the new species and its congeners are summarized in Table 4. ......continued on the next page, Published as part of Li, Ke, Yu, Min, Wu, Ya-Yong, Liao, Lin-Hong, Tang, Kui, Liu, Qin & Guo, Peng, 2020, A new species of the genus Achalinus (Squamata: Xenodermatidae) from southeastern Yunnan Province, China, pp. 116-128 in Zootaxa 4860 (1) on pages 121-123, DOI: 10.11646/zootaxa.4860.1.6, http://zenodo.org/record/4537645, {"references":["Van Denburgh, J. (1912) Concerning certain species of reptiles and amphibians from China, Japan, the Loo Choo Islands, and Formosa. Proceedings of The California Academy of Sciences, 3, 187 - 258. https: // doi. org / 10.1016 / S 1631 - 0691 (02) 01509 - 3","Pope, C. H. (1935) The reptiles of China. Turtles, crocodilians, snakes, lizards. Natural History of central Asia. Vol. X. American Museum of Natural History, New York, 604 pp.","Bourret, R. L. (1935) Notes herpetologiques sur l'Indochine francaise. VIII. Sur les Achalinus d'Indochine. Bulletin Generale de l'Instruction Publique, Hanoi, 15 (5), 101 - 104","Bourret, R. (1937) Notes herpetologiques sur l Indochine francaise. XV. Lezards et serpents recus au Laboratoire des Sciences Naturelles de l' Universite au cours de l' annee 1937. Descriptions de deux especes et de deux varietes nouvelles. Bulletin general de l Instruction Publique, Hanoi, 17 (4), 57 - 80.","Smith, M. A. (1943) The fauna of British India, including Ceylon and Burma. Reptilia and Amphibia. Vol. III. Serpentes. Taylor & Francis Ltd., London, 583 pp.","Koshikawa, A. (1982) Three new species of reptiles from Hainan Island, Guangdong Province. Smithsonian Herpetological Information Service, 53, 1 - 10. https: // doi. org / 10.5479 / si. 23317515.53.1","Karsen, S. J., Lau, M. W. & Bogadek, A. (1986) Hong Kong amphibians and reptiles. Urban Council, Hong Kong, 136 pp.","Ota, H. & Toyama, M. (1989) Taxonomic re-definition of Achalinus formosanus Boulenger (Xenoderminae: Colubridae: Ophidia), with description of a new subspecies. Copeia, 1989 (3), 597 - 602. https: // doi. org / 10.2307 / 1445485.","Zhao, E. M. (2006) Snakes of China. Anhui Science and Technology Publishing House, Hefei, 372 (texts) + 279 pp. (photos). [in Chinese]","Das, I. (2010) A field guide to the reptiles of Southeast Asia. New Holland Publishers (UK) Ltd, London, Cape Town, Sydney and Auckland, 376 pp.","Ziegler, T., Nguyen, T. Q., Pham, C. T., Nguyen, T. T., Pham, A. V., Schingen, V. S., Nguyen, T. T. & Le, M. D. (2019) Three new species of the snake genus Achalinus from Vietnam (Squamata: Xenodermatidae). Zootaxa, 4590 (2), 249 - 269. https: // doi. org / 10.11646 / zootaxa. 4590.2.3","Wang, J., Li, Y., Zeng, Z. C., Lyu, Z. T., Sung, Y. H., Li, Y. Y., Lin, C. Y. & Wang, Y. Y. (2019) A new species of the genus Achalinus from southwestern Guangdong Province, China (Squamata: Xenodermatidae). Zootaxa, 4674 (4), 471 - 481. https: // doi. org / 10.11646 / zootaxa. 4674.4.6","Zong, Y. & Ma, J. (1983) A new species of the genus Achalinopsis from Jiangxi and the restoration of this genus. Acta Herpetologica Sinica, 2 (2), 61 - 63. [in Chinese]"]}

Li, Ke, Yu, Min, Wu, Ya-Yong, Liao, Lin-Hong, Tang, Kui, Liu, Qin, Guo, Peng (2020): A new species of the genus Achalinus (Squamata: Xenodermatidae) from southeastern Yunnan Province, China. Zootaxa 4860 (1): 116-128, DOI: https://doi.org/10.11646/zootaxa.4860.1.6

Shengnan Wang,1,2,* Jing Wu,1,* Congcong Guo,3 Hongxia Shang,4 Jinming Yao,4 Lin Liao,4,5 Jianjun Dong6 1Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, People’s Republic of China; 2Department of Occupational Disease, Yantai Shan Hospital, Yantai, People’s Republic of China; 3Department of Endocrinology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 4Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shandong First Medical University, Jinan, People’s Republic of China; 5Department of Endocrinology and Metabology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 6Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin LiaoDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, People’s Republic of ChinaTel +86 151 6888 8260Fax +86 531 8296 3647Email liaolin@sdu.edu.cnJianjun DongDepartment of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, People’s Republic of ChinaTel +86 137 9112 2910Fax +86 531 8296 7544Email cwc_ll@sdu.edu.cnPurpose: The conventional interventions of anaplastic thyroid carcinoma (ATC) patients are mainly through surgery, chemotherapy, and radiotherapy; however, it is hardly to improve survival rate. We aimed to investigate the differential expressed genes (DEGs) between ATC and normal thyroid gland through bioinformatics analysis of the microarray datasets and find new potential therapeutic targets for ATC.Methods: Microarray datasets GSE9115, GSE29265, GSE33630, GSE53072, and GSE65144 were downloaded from Gene Expression Omnibus (GEO) database. Compared with the normal tissue, GEO2R was conducted to screen the DEGs in each chip under the condition of |log FC| > l, adjusted P‐values (adj. P) < 0.05. The Retrieval of Interacting Genes (STRING) database was used to calculate PPI networks of DEGs with a combined score > 0.4 as the cut-off criteria. The hub genes in the PPI network were visualized and selected according to screening conditions in Cytoscape software. In addition, the novel genes in ATC were screened for survival analysis using Kaplan–Meier plotter from those hub genes and validated by RT-qPCR.Results: A total of 284 overlapping DEGs were obtained, including 121 upregulated and 161 downregulated DEGs. A total of 232 DEGs were selected by STRING database. The 50 hub genes in the PPI network were chosen according to three screening conditions. In addition, the Kaplan–Meier plotter database confirmed that high expressions of ANLN, CENPF, KIF2C, TPX2, and NDC80 were negatively correlated with poor overall survival of ATC patients. Finally, RT-qPCR experiments showed that KIF2C and CENPF were significantly upregulated in ARO cells and CAL-62 cells when compared to Nthy-ori 3– 1 cells, TPX2 was upregulated only in CAL-62 cells, while ANLN and NDC80 were obviously decreased in ARO cells and CAL-62 cells.Conclusion: Our study suggested that CENPF, KIF2C, and TPX2 might play a significant role in the development of ATC, which could be further explored as potential biomarkers for the treatment of ATC.Keywords: anaplastic thyroid carcinoma, bioinformatics analysis, Gene Expression Omnibus database, differential expressed genes

Constructing the glass matrix to avoid the concentration quenching is significant to obtain heavily doping and higher optical gain glasses. In this work, B2O3-Na2O binary glasses with different O/B were employed for discussing the relationship between the glass structure and erbium ions concentration quenching. The Raman spectra indicated that when the O/B was 0.16, the [BO3] would be mostly transformed into [BO4] in the glass network, and furtherly increased O/B, the [BO3] would not be transformed into [BO4] continuously. The critical doping concentration was highest when the O/B was 0.16, which suggested that the relative complete framework structure would be beneficial to obtain homogenously distribution of rare earth ions. Lower O/B, more diverse of the glass structure units, which would be favor to obtain broadband width of NIR fluorescence of Er3+ ions.

Les orgues à bouche sont des instruments traditionnels à anches libres qu’on retrouve sous différentes formes dans plusieurs régions d’Asie de l’Est. Ils demeurent encore aujourd’hui relativement méconnus en Occident mais suscitent de plus en plus l’intérêt des compositeurs et des scientifiques. Dans cette introduction, nous retraçons tout d’abord dans les grandes lignes l’histoire de ces instruments ancestraux, en rappelant comment le shō japonais et le sheng chinois se sont immiscés dans la musique contemporaine au cours de la seconde moitié du XXe siècle grâce à des musiciens d’exception comme Mayumi Miyata et Wu Wei. Nous revenons ensuite sur le contenu de ce numéro qui expose les premiers résultats d’un vaste projet de recherche interdisciplinaire intitulé sheng ! l’orgue à bouche.