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4,213 results on '"Liu, Peter"'

203. 3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial

Author

Seimon, Radhika V., Wild-Taylor, Anthony L., McClintock, Sally, Harper, Claudia, Gibson, Alice A., Johnson, Nathan A., Fernando, Hamish A., Markovic, Tania P., Center, Jacqueline R., Franklin, Janet, Liu, Peter Y., Grieve, Stuart M., Lagopoulos, Jim, Caterson, Ian D., Byrne, Nuala M., and Sainsbury, Amanda

Published
2020
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204. ACR Appropriateness Criteria® Crohn Disease

Author

Kim, David H., Chang, Kevin J., Fowler, Kathryn J., Cash, Brooks D., Garcia, Evelyn M., Kambadakone, Avinash R., Levy, Angela D., Liu, Peter S., Mace, Sharon E., Marin, Daniele, Moreno, Courtney, Peterson, Christine M., Pietryga, Jason A., Solnes, Lilja Bjork, Weinstein, Stefanie, and Carucci, Laura R.

Published
2020
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205. ACR Appropriateness Criteria® Suspected Small-Bowel Obstruction

Author

Chang, Kevin J., Marin, Daniele, Kim, David H., Fowler, Kathryn J., Camacho, Marc A., Cash, Brooks D., Garcia, Evelyn M., Hatten, Benjamin W., Kambadakone, Avinash R., Levy, Angela D., Liu, Peter S., Moreno, Courtney, Peterson, Christine M., Pietryga, Jason A., Siegel, Alan, Weinstein, Stefanie, and Carucci, Laura R.

Published
2020
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209. Technology-Enabled Remote Monitoring and Self-Management — Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol

Author

Mcgillion, Michael H, Devereaux, P J, Yost, Jennifer, Turner, Andy, Bender, Duane, Scott, Ted, Carroll, Sandra L, Ritvo, Paul, Peter, Elizabeth, Lamy, Andre, Furze, Gill, Krull, Kirsten, Dunlop, Valerie, Good, Amber, Bedini, Debbie, Naus, Frank, Pettit, Shirley, Henry, Shaunattonie, Probst, Christine, Mills, Joseph, Gossage, Elaine, Travale, Irene, Duquette, Janine, Taberner, Christy, Bhavnani, Sanjeev, Khan, James, Cowan, David, Romeril, Eric, Lee, John, Collela, T, Choiniere, Manon, Busse, Jason W, Katz, Joel, Victor, J. Charles, Hoch, Jeffrey S, Isranauwatchai, W, Kaasalainen, Sharon, Ladak, Salima SJ, O'Keefe-McCarthy, Sheila, Parry, Monica, Sessler, Daniel, Stacey, Michael, Stevens, Bonnie, Stremler, Robyn, Thabane, Lehana, Watt-Watson, Judy, Whitlock, Richard, Macdermid, Joy C, Leegaard, Marit, McKelvie, Robert, Hillmer, Michael, Cooper, L, Arthur, Gavin, Sider, Krista, Oliver, Susan, Boyajian, Karen, Farrow, Mark, Lawton, Chris, Gamble, Darryl, Welch, Jake, S LeFort S, Field M, Clyne, Wendy, Ricuppero, Maria, Poole, Laurie, Russell-Wood, Karsten, Weber, Michael, McNeil, Jolene, Alpert, Robyn, Sharpe, Sarah, Bhella, Sue, Mohajer, David, Ponnambalam, Sem, Lakhani, Naeem, Khan, Rabia, and Liu, Peter

Subjects
Technology-Enabled, Remote, Monitoring, Self-Management, Vision, Patient, Empowerment, Following, Cardiac, Vascular, Surgery, Testing, Randomized, Controlled, Trial, Protocol
Published
2016

218. The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events, Evaluation of Colchicine Effectiveness (CADENCE): protocol for a randomised, double-blind, placebo-controlled trial

Author

Boczar, Kevin Emery, primary, Shin, Sheojung, additional, deKemp, Robert A, additional, Dowlatshahi, Dar, additional, Tavoosi, Anahita, additional, Wiefels, Christiane, additional, Liu, Peter, additional, Lochnan, Heather, additional, MacPherson, Paul A, additional, Chong, Aun Yeong, additional, Torres, Carlos, additional, Leung, Eugene, additional, Tawakol, Ahmed, additional, Ahmadi, Ali, additional, Garrard, Linda, additional, Lefebvre, Chantal, additional, Kelly, Cathy, additional, MacPhee, Poppy, additional, Tilokee, Everad, additional, Raggi, Paolo, additional, Wells, George A, additional, and Beanlands, Rob, additional

Published
2023
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220. Sodium‐glucose co‐transporter‐2 inhibitors and the risk of venous thromboembolism: A nationwide population‐based study and meta‐analysis

Author

Tsai, Hou‐Ren, primary, Lin, Yu‐Jie, additional, Yeh, Jih‐I, additional, Huang, Yu‐Chi, additional, Liu, Peter Pin‐Sung, additional, Peng, Carol Chiung‐Hui, additional, Hsu, Jin‐Yi, additional, Lee, Yuan‐Chieh, additional, Loh, Ching‐Hui, additional, Lin, Shu‐Man, additional, and Huang, Huei‐Kai, additional

Published
2023
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225. FRI436 Design Of An International Male Contraceptive Efficacy Trial Using A Self-administered Daily Topical Gel Containing Testosterone And Nestorone™

Author

Page, Stephanie T, primary, Amory, John K, additional, Blithe, Diana, additional, Sitruk-Ware, Regine, additional, Swerdloff, Ronald, additional, Bremner, William, additional, Liu, Peter, additional, Anawalt, Bradley D, additional, Thirumalai, Arthi, additional, Nguyen, Brian, additional, Dart, Clint, additional, Lee, Min, additional, and Wang, Christina, additional

Published
2023
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227. Strong coupling in the far-infrared between graphene plasmons and the surface optical phonons of silicon dioxide

Author

Luxmoore, Isaac. J., Gan, Choon How, Liu, Peter Q., Valmorra, Federico, Li, Penglei, Faist, Jerome, and Nash, Geoffrey R.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study plasmonic resonances in electrostatically gated graphene nanoribbons on silicon dioxide substrates. Absorption spectra are measured in the mid-far infrared and reveal multiple peaks, with width-dependent resonant frequencies. We calculate the dielectric function within the random phase approximation and show that the observed spectra can be explained by surface-plasmon-phonon-polariton modes, which arise from coupling of the graphene plasmon to three surface optical phonon modes in the silicon dioxide.

Published
2014
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229. RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

Author

Karunakaran, Denuja, Turner, Adam W., Duchez, Anne-Claire, Soubeyrand, Sebastien, Rasheed, Adil, Smyth, David, Cook, David P., Nikpay, Majid, Kandiah, Joshua W., Pan, Calvin, Geoffrion, Michele, Lee, Richard, Boytard, Ludovic, Wyatt, Hailey, Nguyen, My-Anh, Lau, Paulina, Laakso, Markku, Ramkhelawon, Bhama, Alvarez, Marcus, Pietiläinen, Kirsi H., Pajukanta, Päivi, Vanderhyden, Barbara C., Liu, Peter, Berger, Scott B., Gough, Peter J., Bertin, John, Harper, Mary-Ellen, Lusis, Aldons J., McPherson, Ruth, and Rayner, Katey J.

Published
2020
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230. Metabolic and hormonal effects of ‘catch‐up’ sleep in men with chronic, repetitive, lifestyle‐driven sleep restriction

Author

Killick, Roo, Hoyos, Camilla M, Melehan, Kerri L, Dungan, George C, Poh, Jonathon, and Liu, Peter Y

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Research, Nutrition, Diabetes, Obesity, Sleep Research, Metabolic and endocrine, Adult, Blood Glucose, Body Mass Index, C-Peptide, Cross-Over Studies, Ghrelin, Glucose Tolerance Test, Humans, Hydrocortisone, Insulin, Leptin, Luteinizing Hormone, Male, Peptide YY, Sleep, Sleep Deprivation, Testosterone, Clinical Sciences, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences
Abstract

ObjectiveAcutely restricting sleep worsens insulin sensitivity in healthy individuals whose usual sleep is normal in duration and pattern. The effect of recovery or weekend 'catch-up' sleep on insulin sensitivity and metabolically active hormones in individuals with chronic sleep restriction who regularly 'catch-up' on sleep at weekends is as yet unstudied.Design19 men (mean ± SEM age 28·6 ± 2·0 years, BMI 26·0 ± 0·8 kg/m(2) ) with at least 6 months' history (5·1 ± 0·9 years) of lifestyle-driven, restricted sleep during the working week (373 ± 6·6 min/night) with regular weekend 'catch-up' sleep (weekend sleep extension 37·4 ± 2·3%) completed an in-laboratory, randomized, crossover study comprising two of three conditions, stratified by age. Conditions were 3 weekend nights of 10 hours, 6 hours or 10 hours time-in-bed with slow wave sleep (SWS) suppression using targeted acoustic stimuli.MeasurementsInsulin sensitivity was measured in the morning following the 3rd intervention night by minimal modelling of 19 samples collected during a 2-h oral glucose tolerance test. Glucose, insulin, c-peptide, leptin, peptide YY (PYY), ghrelin, cortisol, testosterone and luteinizing hormone (LH) were measured from daily fasting blood samples; HOMA-IR, HOMA-β and QUICKI were calculated.ResultsInsulin sensitivity was higher following three nights of sleep extension compared to sustained sleep restriction. Fasting insulin, c-peptide, HOMA-IR, HOMA-β, leptin and PYY decreased with 'catch-up' sleep, QUICKI and testosterone increased, while morning cortisol and LH did not change. Targeted acoustic stimuli reduced SWS by 23%, but did not alter insulin sensitivity.ConclusionsThree nights of 'catch-up' sleep improved insulin sensitivity in men with chronic, repetitive sleep restriction. Methods to improve metabolic health by optimizing sleep are plausible.

Published
2015

238. Structure of the essential inner membrane lipopolysaccharide-PbgA complex

Author

Clairfeuille, Thomas, Buchholz, Kerry R., Li, Qingling, Verschueren, Erik, Liu, Peter, Sangaraju, Dewakar, and Park, Summer

Subjects
Lipopolysaccharides -- Control, Membrane proteins -- Identification and classification, Cell membranes -- Analysis, Escherichia coli -- Structure, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function.sup.1,2. LPS can cause death as a result of septic shock, and its lipid A core is the target of polymyxin antibiotics.sup.3,4. Despite the clinical importance of polymyxins and the emergence of multidrug resistant strains.sup.5, our understanding of the bacterial factors that regulate LPS biogenesis is incomplete. Here we characterize the inner membrane protein PbgA and report that its depletion attenuates the virulence of Escherichia coli by reducing levels of LPS and outer membrane integrity. In contrast to previous claims that PbgA functions as a cardiolipin transporter.sup.6-9, our structural analyses and physiological studies identify a lipid A-binding motif along the periplasmic leaflet of the inner membrane. Synthetic PbgA-derived peptides selectively bind to LPS in vitro and inhibit the growth of diverse Gram-negative bacteria, including polymyxin-resistant strains. Proteomic, genetic and pharmacological experiments uncover a model in which direct periplasmic sensing of LPS by PbgA coordinates the biosynthesis of lipid A by regulating the stability of LpxC, a key cytoplasmic biosynthetic enzyme.sup.10-12. In summary, we find that PbgA has an unexpected but essential role in the regulation of LPS biogenesis, presents a new structural basis for the selective recognition of lipids, and provides opportunities for future antibiotic discovery. Structural and physiological studies show that the inner membrane protein PbgA is a crucial sensor of lipopolysaccharide (LPS) and regulates the activity of the LPS biosynthesis enzyme LpxC., Author(s): Thomas Clairfeuille [sup.1] , Kerry R. Buchholz [sup.2] , Qingling Li [sup.3] , Erik Verschueren [sup.3] , Peter Liu [sup.3] , Dewakar Sangaraju [sup.4] , Summer Park [sup.5] , [...]

Published
2020
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240. Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion

Author

Verweij, Paul E., Rijnders, Bart J. A., Brüggemann, Roger J. M., Azoulay, Elie, Bassetti, Matteo, Blot, Stijn, Calandra, Thierry, Clancy, Cornelius J., Cornely, Oliver A., Chiller, Tom, Depuydt, Pieter, Giacobbe, Daniele Roberto, Janssen, Nico A. F., Kullberg, Bart-Jan, Lagrou, Katrien, Lass-Flörl, Cornelia, Lewis, Russell E., Liu, Peter Wei-Lun, Lortholary, Olivier, Maertens, Johan, Martin-Loeches, Ignacio, Nguyen, M. Hong, Patterson, Thomas F., Rogers, Thomas R., Schouten, Jeroen A., Spriet, Isabel, Vanderbeke, Lore, Wauters, Joost, and van de Veerdonk, Frank L.

Published
2020
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245. The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

Author

Suryamohan, Kushal, Krishnankutty, Sajesh P., Guillory, Joseph, Jevit, Matthew, Schröder, Markus S., Wu, Meng, Kuriakose, Boney, Mathew, Oommen K., Perumal, Rajadurai C., Koludarov, Ivan, Goldstein, Leonard D., Senger, Kate, Dixon, Mandumpala Davis, Velayutham, Dinesh, Vargas, Derek, Chaudhuri, Subhra, Muraleedharan, Megha, Goel, Ridhi, Chen, Ying-Jiun J., Ratan, Aakrosh, Liu, Peter, Faherty, Brendan, de la Rosa, Guillermo, Shibata, Hiroki, Baca, Miriam, Sagolla, Meredith, Ziai, James, Wright, Gus A., Vucic, Domagoj, Mohan, Sangeetha, Antony, Aju, Stinson, Jeremy, Kirkpatrick, Donald S., Hannoush, Rami N., Durinck, Steffen, Modrusan, Zora, Stawiski, Eric W., Wiley, Kristen, Raudsepp, Terje, Kini, R. Manjunatha, Zachariah, Arun, and Seshagiri, Somasekar

Published
2020
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247. The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs

Author

Jia, Yue, Ohanyan, Aikoui, Lue, Yan-He, Swerdloff, Ronald S, Liu, Peter Y, Cohen, Pinchas, and Wang, Christina

Subjects
Biochemistry and Cell Biology, Biological Sciences, Infertility, Cancer, 1.1 Normal biological development and functioning, Underpinning research, Animals, Antineoplastic Agents, Apoptosis, Cyclophosphamide, Doxorubicin, Germ Cells, Intracellular Signaling Peptides and Proteins, Male, Mice, Testis, Humanin, Germ cell apoptosis, Chemotherapy, Medical Physiology, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

Human (HN) prevents stress-induced apoptosis in many cells/tissues. In this study we showed that HN ameliorated chemotherapy [cyclophosphamide (CP) and Doxorubicin (DOX)]-induced male germ cell apoptosis both ex vivo in seminiferous tubule cultures and in vivo in the testis. HN acts by several putative mechanisms via binding to: an IL-12 like trimeric membrane receptor; BAX; or insulin-like growth factor binding protein-3 (IGFBP-3, a proapoptotic factor). To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice. CP-induced germ cell apoptosis was inhibited by HN, HNG, HNG-F6A, HN-S7A, and HN-C8P (less effective); but not by HN-L12A. HN-L12A, but not HN-S7A or HN-C8P, blocked the protective effect of HN against CP-induced male germ cell apoptosis. HN, HN-S7A, and HN-C8P restored CP-suppressed STAT3 phosphorylation. These results suggest that HN: (1) decreases DOX (ex vivo) and CP (in vivo) induced male germ cell apoptosis; (2) action is mediated by the membrane receptor/STAT3 with minor contribution by BAX-binding pathway; (3) self-dimerization or binding to IGFBP-3 may not be involved in HN's effect in testis. HN is an important molecule in the regulation of germ cell homeostasis after injury and agonistic analogues may be developed for treating male infertility or protection against chemotherapy side effects.

Published
2015

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