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1,017 results on '"Madry, Henning"'

203. Biological effects of FGF-2 and IGF-I Co-overexpression in human bone marrow-derived mesenchymal stem cells via rAAV vector administration

Author

Böhm, Teresa, Venkatesan, Jagadeesh K., Rey-Rico, Ana, Schmitt, Gertrud, Madry, Henning, and Cucchiarini, Magali

Subjects
ddc: 610, viruses, regenerative medicine, 610 Medical sciences, Medicine, cartilage, gene therapy
Abstract

Objectives: Gene-based modification of bone marrow-derived mesenchymal stem cells (MSCs)is an attractive approach to treat articular cartilage defects. Here, we tested the benefits of co-delivering rAAV-FGF-2 and rAAV-IGF-I in human MSCs as a tool to enhance the cartilage repair. Methods: rAAV-lacZ[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

Published
2018

204. rAAV-vermittelter Gentransfer von humanem FGF-2 verbessert signifikant die Reparatur von fokalen osteochondralen Defekten - eine Studie im translationalen Schafmodell

Author

Morscheid, Yannik, Venkatesan, Jagadeesh, Zurakowski, David, Laschke, Matthias W., Menger, Michael, Cucchiarini Madry, Magali, and Madry, Henning

Subjects
Osteochondrale Defekte, Gentherapie, ddc: 610, FGF-2, 610 Medical sciences, Medicine, rAAV
Abstract

Fragestellung: Fokale, osteochondrale Defekte sind ein ungelöstes klinisches Problem. Im Kleintiermodell konnte bereits gezeigt werden, dass humaner Fibroblastenwachstumsfaktor 2 (hFGF-2) in osteochondralen Defekten gentransferbasiert überexprimiert werden kann und dabei einen positiven Effekt[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

Published
2018

207. Tissue Engineering Using Transfected Growth-Factor Genes

Author

Madry, Henning, Langer, Robert S, Freed, Lisa E, Trippel, Stephen, and Vunjak-Novakovic, Gordana

Subjects
Man/System Technology And Life Support
Abstract

A method of growing bioengineered tissues includes, as a major component, the use of mammalian cells that have been transfected with genes for secretion of regulator and growth-factor substances. In a typical application, one either seeds the cells onto an artificial matrix made of a synthetic or natural biocompatible material, or else one cultures the cells until they secrete a desired amount of an extracellular matrix. If such a bioengineered tissue construct is to be used for surgical replacement of injured tissue, then the cells should preferably be the patient s own cells or, if not, at least cells matched to the patient s cells according to a human-leucocyteantigen (HLA) test. The bioengineered tissue construct is typically implanted in the patient's injured natural tissue, wherein the growth-factor genes enhance metabolic functions that promote the in vitro development of functional tissue constructs and their integration with native tissues. If the matrix is biodegradable, then one of the results of metabolism could be absorption of the matrix and replacement of the matrix with tissue formed at least partly by the transfected cells. The method was developed for articular chondrocytes but can (at least in principle) be extended to a variety of cell types and biocompatible matrix materials, including ones that have been exploited in prior tissue-engineering methods. Examples of cell types include chondrocytes, hepatocytes, islet cells, nerve cells, muscle cells, other organ cells, bone- and cartilage-forming cells, epithelial and endothelial cells, connective- tissue stem cells, mesodermal stem cells, and cells of the liver and the pancreas. Cells can be obtained from cell-line cultures, biopsies, and tissue banks. Genes, molecules, or nucleic acids that secrete factors that influence the growth of cells, the production of extracellular matrix material, and other cell functions can be inserted in cells by any of a variety of standard transfection techniques.

Published
2005

208. A low morbidity surgical approach to the sheep femoral trochlea

Author

Orth Patrick and Madry Henning

Subjects
Cartilage, Sheep, Trochlea, Patella, Luxation, In vivo, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background The ovine stifle joint is an important location for investigations on the repair of articular cartilage defects in preclinical large animals. The classical medial parapatellar approach to the femoral trochlea is hazardous because of the high risk of postoperative patellar luxation. Here, we describe a low morbidity surgical exposure of the ovine trochlea without the necessity for intraoperative patellar luxation. Methods Bilateral surgical exposure of the femoral trochlea of the sheep stifle joint was performed using the classical medial parapatellar approach with intraoperative lateral patellar luxation and transection of the medial patellar retinaculum in 28 ovine stifle joints. A low morbidity approach was performed bilaterally in 116 joints through a mini-arthrotomy without the need to transect the medial patellar retinaculum or the oblique medial vastus muscle nor surgical patellar luxation. Postoperatively, all 72 animals were monitored to exclude patellar luxations and deep wound infections. Results The novel approach could be performed easily in all joints and safely exposed the distal two-thirds of the medial and lateral trochlear facet. No postoperative patellar luxations were observed compared to a postoperative patellar luxation rate of 25% experienced with the classical medial parapatellar approach and a re-luxation rate of 80% following revision surgery. No signs of lameness, wound infections, or empyema were observed for both approaches. Conclusions The mini-arthrotomy presented here yields good exposure of the distal ovine femoral trochlea with a lower postoperative morbidity than the classical medial parapatellar approach. It is therefore suitable to create articular cartilage defects on the femoral trochlea without the risk of postoperative patellar luxation.

Published
2013
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209. Static winging of the scapula caused by osteochondroma in adults: a case series

Author

Orth Patrick, Anagnostakos Konstantinos, Fritsch Ekkehard, Kohn Dieter, and Madry Henning

Subjects
Osteochondroma, Scapula alata, Scapular winging, Medicine
Abstract

Abstract Introduction Although palsy of the long thoracic nerve is the classical pathogenesis of winging scapula, it may also be caused by osteochondroma. This rare etiopathology has previously been described in pediatric patients, but it is seldom observed in adults. Case presentation We describe three cases of static scapular winging with pain on movement. Case 1 is a Caucasian woman aged 35 years with a wing-like prominence of the medial margin of her right scapula due to an osteochondroma originating from the ventral omoplate. Histopathological evaluation after surgical resection confirmed the diagnosis. The postoperative course was unremarkable without signs of recurrence on examination at 2 years. Case 2 is a Caucasian woman aged 39 years with painful scapula alata and neuralgic pain projected along the left ribcage caused by an osteochondroma of the left scapula with contact to the 2nd and 3rd rib. Following surgical resection, the neuropathic pain continued, demanding neurolysis of the 3rd and 4th intercostal nerve after 8 months. The patient was free of symptoms 2 years after neurolysis. Case 3 is a Caucasian woman aged 48 years with scapular winging due to a large exostosis of the left ventral scapular surface with a broad cartilaginous cap and a large pseudobursa. Following exclusion of malignancy by an incisional biopsy, exostosis and pseudobursa were resected. The patient had an unremarkable postoperative course without signs of recurrence 1 year postoperatively. Based on these cases, we developed an algorithm for the diagnostic evaluation and therapeutic management of scapula alata due to osteochondroma. Conclusions Orthopedic surgeons should be aware of this uncommon condition in the differential diagnosis of winged scapula not only in children, but also in adult patients.

Published
2012
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213. An overview of thermal necrosis: present and future

Author

Mediouni, Mohamed, primary, Kucklick, Theodore, additional, Poncet, Sébastien, additional, Madiouni, Riadh, additional, Abouaomar, Amine, additional, Madry, Henning, additional, Cucchiarini, Magali, additional, Chopko, Bohdan, additional, Vaughan, Neil, additional, Arora, Manit, additional, Gökkuş, Kemal, additional, Lozoya Lara, Mario, additional, Paiva Cedeño, Lorenlay, additional, Volosnikov, Alexander, additional, Hesmati, Mohamed, additional, and Ho, Kevin, additional

Published
2019
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216. Genetic modification of human bone marrow aspirates via delivery of rAAV vectors coated on pNaSS-grafted poly(epsilon-caprolactone) scaffolds

Author

Venkatesan, Jagadeesh K., Leroux, Amélie, Baumann, Jean-Sébastien, Rey-Rico, Ana, Falentin-Daudré, Céline, Madry, Henning, Migonney, Veronique, and Cucchiarini, Magali

Subjects
Cartilage, ddc: 610, PCL, viruses, 610 Medical sciences, Medicine, rAAV
Abstract

Objectives: Articular cartilage has a limited ability for self-healing. Gene transfer using the clinically relevant recombinant adeno-associated viral (rAAV) vectors is a powerful tool to enhance cartilage repair. Here, we tested the ability of various poly(sodium styrene sulfonate) grafted poly(ε[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Published
2017

217. Effective transduction of human articular chondrocytes in vitro and in a human osteochondral defect model via polymeric micelles

Author

Rey-Rico, Ana, Venkatesan, Jagadeesh K., Frisch, Janina, Taboada, Pablo, Concheiro, Angel, Madry, Henning, Alvarez-Lorenzo, Carmen, and Cucchiarini, Magali

Subjects
ddc: 610, micelles, viruses, osteoarthritis (OA), neutralizing antibodies, osteochondral defect, 610 Medical sciences, Medicine, recombinant adeno-associated viral vectors (rAAV)
Abstract

Objectives: rAAV vectors are attractive tools for the durable treatment of human osteoarthritis (OA). Still, their adapted use in vivo is impaired by neutralizing antibodies against viral capsid elements in patients. Delivery of rAAV via polymeric micelles may allow overcoming these hurdles. Here, we[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Published
2017

220. Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus–MediatedSOX9Gene Transfer

Author

Venkatesan, Jagadeesh K., primary, Moutos, Franklin T., additional, Rey-Rico, Ana, additional, Estes, Bradley T., additional, Frisch, Janina, additional, Schmitt, Gertrud, additional, Madry, Henning, additional, Guilak, Farshid, additional, and Cucchiarini, Magali, additional

Published
2018
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222. Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects

Author

Madry, Henning, Gao, Liang, Eichler, Hermann, Orth, Patrick, and Cucchiarini, Magali

Subjects
Article Subject
Abstract

Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. Moreover, the BMA clot provides a three-dimensional environment, possibly further supporting chondrogenesis and protecting the subchondral bone from structural alterations. The purpose of this review is to bridge the gap in our understanding between the basic science knowledge on MSCs and BMA and the clinical and technical aspects of marrow stimulation-based cartilage repair by examining available data on the role and mechanisms of MSCs and BMA in osteochondral repair. Implications of findings from both translational and clinical studies using BMA concentrate-enhanced marrow stimulation are discussed.

Published
2017
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223. Kleine Bohrlochdurchmesser verbessern die biochemischen Eigenschaften des Reparaturknorpels nach subchondraler Anbohrung in vivo

Author

Orth, Patrick, Eldracher, Mona, Kohn, Dieter, Menger, Michael, Cucchiarini, Magali, and Madry, Henning

Subjects
Typ I Kollagen, Typ II Kollagen, ddc: 610, Knorpel, Zellzahl, Schaf, 610 Medical sciences, Medicine, subchondrale Anbohrung, Proteoglykan
Abstract

Fragestellung: Die subchondrale Anbohrung ist eine etablierte Technik zur Behandlung kleinflächiger Knorpeldefekte. Aktuelle Daten zeigen den Vorteil kleiner gegenüber großen Bohrlochdurchmessern hinsichtlich histologischer und radiologischer Parameter der osteochondralen Reparatur [Eldracher[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016)

Published
2016
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227. Erratum: Stellenwert der matrixaugmentierten Knochenmarkstimulation in der Behandlung von Knorpelschäden des Kniegelenks: Konsensusempfehlungen der AG Klinische Geweberegeneration der DGOU

Author

Niemeyer, Philipp, additional, Becher, Christoph, additional, Brucker, Peter U., additional, Buhs, Matthias, additional, Fickert, Stefan, additional, Gelse, Kolja, additional, Günther, Daniel, additional, Kaelin, Raphael, additional, Kreuz, Peter, additional, Lützner, Jörg, additional, Nehrer, Stefan, additional, Madry, Henning, additional, Marlovits, Stefan, additional, Mehl, Julian, additional, Ott, Henning, additional, Pietschmann, Matthias, additional, Spahn, Gunther, additional, Tischer, Thomas, additional, Volz, Martin, additional, Walther, Markus, additional, Welsch, Götz, additional, Zellner, Johannes, additional, Zinser, Wolfgang, additional, and Angele, Peter, additional

Published
2018
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230. Stellenwert der matrixaugmentierten Knochenmarkstimulation in der Behandlung von Knorpelschäden des Kniegelenks: Konsensusempfehlungen der AG Klinische Geweberegeneration der DGOU

Author

Niemeyer, Philipp, additional, Becher, Christoph, additional, Brucker, Peter, additional, Buhs, Matthias, additional, Fickert, Stefan, additional, Gelse, Kolja, additional, Günther, Daniel, additional, Kaelin, Raphael, additional, Kreuz, Peter, additional, Lützner, Jörg, additional, Nehrer, Stefan, additional, Madry, Henning, additional, Marlovits, Stefan, additional, Mehl, Julian, additional, Ott, Henning, additional, Pietschmann, Matthias, additional, Spahn, Gunther, additional, Tischer, Thomas, additional, Volz, Martin, additional, Walther, Markus, additional, Welsch, Götz, additional, Zellner, Johannes, additional, Zinser, Wolfgang, additional, and Angele, Peter, additional

Published
2018
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232. Erratum: Stellenwert des Débridements bei der Behandlung fokaler (Grad II – III) Knorpelschäden des Kniegelenks. Systematische Literaturübersicht und Empfehlungen der AG Geweberegeneration (DGOU)

Author

Gelse, Kolja, additional, Angele, Peter, additional, Behrens, Peter, additional, Brucker, Peter U., additional, Fay, Jakob, additional, Günther, Daniel, additional, Kreuz, Peter, additional, Lützner, Jörg, additional, Madry, Henning, additional, Müller, Peter E., additional, Niemeyer, Philipp, additional, Pagenstert, Geert, additional, Tischer, Thomas, additional, Walther, Markus, additional, Zinser, Wolfgang, additional, and Spahn, Gunter, additional

Published
2018
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235. Stellenwert des Débridements bei der Behandlung fokaler (Grad II – III) Knorpelschäden des Kniegelenks. Systematische Literaturübersicht und Empfehlungen der AG Geweberegeneration (DGOU)

Author

Gelse, Kolja, additional, Angele, Peter, additional, Behrens, Peter, additional, Brucker, Peter, additional, Fay, Jakob, additional, Günther, Daniel, additional, Kreuz, Peter, additional, Lützner, Jörg, additional, Madry, Henning, additional, Müller, Peter, additional, Niemeyer, Philipp, additional, Pagenstert, Geert, additional, Tischer, Thomas, additional, Walther, Markus, additional, Zinser, Wolfgang, additional, and Spahn, Gunter, additional

Published
2018
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240. List of contributors

Author

Abe, Masashi, Ahlstrom, Jon D., Albon, Julie, Allickson, Julie, Almeida-Porada, Graça, Altschuler, Richard A., Anderson, Daniel G., Annabi, Nasim, Arcidiacono, Judith, Ashammakhi, Nureddin, Atala, Anthony, Athanasiou, Kyriacos A., Awad, Hani A., Badylak, Stephen F, Balachander, Gowri, Balkan, Wayne, Bara, Jennifer J., Barry, Michael P., Baskaran, Harihara, Bedell, Matthew L., Belcher, Donald Andrew, Berry, David B., Bhat, Hina, Bhat, Zuhaib F., Bhatia, Sangeeta N., Blackburn, Catherine Clare, Blocki, Anna, Blum, Kevin M., Bochenek, Matthew A., Bonassar, Lawrence J., Bonventre, Joseph V., Borrelli, Mimi R., Bowles, Robby D., Bradshaw, Amy D., Bratt-Leal, Andres M., Breuer, Christopher K., Brewster, Luke, Brey, Eric M., Briquez, Priscilla S., Buckwalter, J.A., Burg, Karen J.L., Burg, Timothy C., Byambaa, Batzaya, Chandra, Prafulla K., Chen, Amanda X., Chen, Fa-Ming, Chen, Shaochen, Chesterman, Julian, Chhabra, Arnav, Chong, Seow Khoon, Clark, Richard A.F., Cleary, Muriel A., Coleman, M., Cotsarelis, George, Crystal, Ronald G., Dagnelie, Gislin, Darabi, Mohammad Ali, Davidson, Jeffrey M., Davidson, Joseph, De Coppi, Paolo, Delcassian, Derfogail, de Vos, Paul, Dominijanni, Anthony, Donahue, Ryan, Drain, Allison P., Duvall, Craig L., Dziki, Jenna L., Elgalad, Abdelmotagaly, Eng, George, Falanga, Vincent, Farhang, Niloofar, Ferreira, Lino, Fink, Donald W., Jr., Fleming, Heather E., Fong, Peter, Frey, Mark R., Gay, Denise, Gerecht, Sharon, Gersbach, Charles A., Gibbs, D.M.R., Gidwani, Simran, González Morales, Shaimar R., Goyal, Ritu, Grant, Maria B., Gray, Andrea, Greisler, Howard P., Grikscheit, Tracy C., Grosh, Karl, Guilak, Farshid, Guo, Jason L., Han, Yingli, Hare, Joshua M., Hassanbhai, Ammar Mansoor, Hatzistergos, Konstantinos, Hay, David C., He, Xiao-Tao, Henderson, Timothy, Hickerson, Darren, Hickerson, Darren H.M., Hmadcha, Abdelkrim, Hochman-Mendez, Camila, Huang, Chao, Hubbell, Jeffrey A., Huelsmann, Joern, Huh, Jun Tae, Hunsberger, Joshua G., Iannucci, Leanne E., Inoue, Haruhisa, Jackson, John, Jiang, Yangzi, Kalinichenko, Vladimir V., Kanczler, J.M., Karp, Jeffrey M., Kasper, F. Kurtis, Khademhosseini, Ali, Kim, Ji Hyun, Kimbrel, Erin A., Klimanskaya, Irina, Kohn, Joachim, Kumar, Sunil, Kyriakides, Themis R., Lake, Spencer P., Lam, Johnny, Langer, Robert, Lanza, Robert, Leach, Timothy S., Lee, Benjamin W., Lee, Iris, Lee, Sang Jin, Li, David, Li, Linheng, Liu, Qian, Ljubimov, Alexander V., Lo, Chi, Longaker, Michael T., López-Beas, Javier, Loring, Jeanne F., Luo, Ying, MacArthur, Ben D., Madigan, Nicolas N., Madry, Henning, Magalhaes, Renata S., Manley, Nancy Ruth, Mansbridge, Jonathan, Mao, Jeremy J., Marshall, K.M., Martin, J.A., Martins-Green, M., Maselli, Kathryn M., Maxfield, Mark W., McCracken, Kyle W., Melville, James, Mikos, Antonios G., Millán, José del R., Mirotsou, Maria, Montoro, Daniel T., Murphy, Matthew P., Murphy, Sean V., Musillo, Michael, Muthukumaran, Padmalosini, Navara, Adam M., Nelson, Christopher E., Niklason, Laura E., Nowell, Craig Scott, O’Keefe, Regis J., O’Neill, Kathy E., Oreffo, Richard O.C., Ortiz, Ophir, Palmer, Andre Francis, Perdikis, Serafeim, Petreaca, M., Plikus, Maksim V., Porada, Christopher D., Post, Mark, Prokop, Aleš, Puri, Raj K., Qian, Pengxu, Radisic, Milica, Raredon, Micha Sam Brickman, Richie, Ellen Rothman, Rouse, Paul, Sadri-Ardekani, Hooman, Saltzman, W. Mark, Sampaio, Luiz C., Schlieve, Christopher R., Sha, Su-Hua, Sharpe, Paul T., Shastri, V. Prasad, Shi, Yanhong, Shupe, Thomas, Sirabella, Dario, Skardal, Aleksander, Slack, J.M.W., Sloan, Stephen R., Jr., Soker, Shay, Soria, Bernat, Soria-Juan, Bárbara, Stockdale, Frank E., Stover, Josh, Stransky, Thomas, Stronks, H. Christiaan, Stumpf, Patrick S., Sung, Kyung Eun, Swarr, Daniel, Szkolnicka, Dagmara, Takahashi, Jun, Tang, D.K.O., Tang, Winson, Taylor, Doris A., Teng, Yao, Teoh, Swee Hin, Smith, Anthony J., Treffeisen, Elsa, Tuan, Rocky S., Vacanti, Joseph P., van der Weele, Cor, Vincent, Matthew, Vunjak-Novakovic, Gordana, Wahlberg, Lars U., Wan, Derrick C., Wang, Anne, Wang, Dan, Wang, Qiwei, Wang, Yanling, Wang, Yu-li, Wang, Zhanwen, Weaver, Valerie M., Wells, J.A., Welter, Jean F., Wen, Feng, Weston, Jake, Whitsett, Jeffrey A., Williams, James K., Windebank, Anthony J., Wong, Mark Eu-Kien, Worgall, Stefan, Wu, Iwen, Wu, Rui-Xin, Xie, Virginia Y., Xing, Malcolm, Yamada, Kenneth M., Yamanaka, Shinya, Yoo, James J., Young, Simon, Yu, Claire, Yu, Hanry, Yuan, Yifan, Zacharias, William, Zakko, Jason, Zhang, Ai, Zhang, Yuanyuan, Zhang, Zheng, Zhao, Chunfeng, Zhao, Yimu, and Zoloth, Laurie

Published
2020
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241. rAAV-based genetic modification of human bone marrow aspirates seeded in 3D woven poly(epsilon-caprolactone) scaffolds

Author

Cucchiarini Madry, Magali, Frisch, Janina, Rey-Rico, Ana, Venkatesan, Jagadeesh K., Schmitt, Gertrud, Moutos, Franklin, Guilak, Farshid, and Madry, Henning

Subjects
Cartilage, Tissue Engineering, ddc: 610, Gene Therapy, 610 Medical sciences, Medicine, Regenerative Medicine
Abstract

Objectives: Bone marrow aspirates are attractive platforms to deliver candidate genes to enhance the repair of cartilage defects. Yet, aspirates may not have a sufficient integrity to support joint loading in a defect repair site. Here, we tested the ability of rAAV vectors to modify human bone marrow[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

Published
2015

242. Influence of IGF-I overexpression via rAAV gene transfer upon the chondrogenic differentiation potential of human bone marrow aspirates

Author

Frisch, Janina, Rey Rico, Ana, Venkatesan, Jagadeesh K., Schmitt, Gertrud, Madry, Henning, and Cucchiarini Madry, Magali

Subjects
Bone Marrow Aspirates, ddc: 610, viruses, Cartilage Repair, Gene Therapy, 610 Medical sciences, Medicine, IGF-I
Abstract

Objectives: Implantation of bone marrow aspirates modified by recombinant adeno-associated viral (rAAV) vectors is a promising approach to improve the healing of articular cartilage defects. In the present study, we investigated the effects of prolonged overexpression of the mitogenic and pro-anabolic[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

Published
2015

243. Effects of static versus dynamic culture conditions upon the chondrogenic differentiation potential of human bone marrow aspirates following rAAV-mediated overexpression of sox9

Author

Venkatesan, Jagadeesh K., Rey-Rico, Ana, Frisch, Janina, Schmitt, Gertrud, Madry, Henning, and Cucchiarini, Magali

Subjects
Cartilage, ddc: 610, Gene Therapy, 610 Medical sciences, Medicine, Regenerative Medicine
Abstract

Objectives: Gene-based modification of bone marrow aspirates is an attractive approach to treat articular cartilage defects. Here, we examined the potential of rAAV-mediated sox9 gene transfer to enhance the chondrogenic differentiation processes in human bone marrow aspirates under dynamic versus static[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

Published
2015

244. Biologische Rekonstruktion lokalisiert vollschichtiger Knorpelschäden des Hüftgelenks: Empfehlungen der Arbeitsgemeinschaft „Klinische Geweberegeneration“ der DGOU und des Hüftkomitees der AGA

Author

Fickert, Stefan, additional, Aurich, Matthias, additional, Albrecht, Dirk, additional, Angele, Peter, additional, Büchler, Lorenz, additional, Dienst, Michael, additional, Erggelet, Christoph, additional, Fritz, Jürgen, additional, Gebhart, Christoph, additional, Gollwitzer, Hans, additional, Kindler, Moritz, additional, Lampert, Christoph, additional, Madry, Henning, additional, Möckel, Gregor, additional, Niemeyer, Phillip, additional, Schröder, Jörg, additional, Sobau, Christian, additional, Spahn, Gunter, additional, Zinser, Wolfgang, additional, and Landgraeber, Stefan, additional

Published
2017
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245. rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model

Author

Rey-Rico, Ana, primary, Venkatesan, Jagadeesh Kumar, additional, Schmitt, Gertrud, additional, Concheiro, Angel, additional, Madry, Henning, additional, Alvarez-Lorenzo, Carmen, additional, and Cucchiarini, Magali, additional

Published
2017
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250. Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model

Author

Friedman, James M., primary, Sennett, Mackenzie L., additional, Bonadio, Marcelo B., additional, Orji, Kerry O., additional, Neuwirth, Alexander L., additional, Keah, Niobra, additional, Carey, James L., additional, Moutos, Franklin T., additional, Estes, Bradley T., additional, Guilak, Farshid, additional, Madry, Henning, additional, Mauck, Robert L., additional, and Dodge, George R., additional

Published
2017
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