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201. Performance in adolescents of the two Japanese serum creatinine based estimated glomerular filtration rate equations, for adults and paediatric patients: A study of the Japan Renal Biopsy Registry and Japan Kidney Disease Registry from 2007 to 2013

Author

Uemura, Osamu, primary, Yokoyama, Hitoshi, additional, Ishikura, Kenji, additional, Gotoh, Yoshimitsu, additional, Sato, Hiroshi, additional, Sugiyama, Hitoshi, additional, Honda, Masataka, additional, and Matsuo, Seiichi, additional

Published
2017
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202. Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes

Author

Furuichi, Kengo, primary, Yuzawa, Yukio, additional, Shimizu, Miho, additional, Hara, Akinori, additional, Toyama, Tadashi, additional, Kitamura, Hiroshi, additional, Suzuki, Yoshiki, additional, Sato, Hiroshi, additional, Uesugi, Noriko, additional, Ubara, Yoshifumi, additional, Hisano, Satoshi, additional, Ueda, Yoshihiko, additional, Nishi, Shinichi, additional, Yokoyama, Hitoshi, additional, Nishino, Tomoya, additional, Kohagura, Kentaro, additional, Ogawa, Daisuke, additional, Mise, Koki, additional, Shibagaki, Yugo, additional, Kimura, Kenjiro, additional, Haneda, Masakazu, additional, Makino, Hirofumi, additional, Matsuo, Seiichi, additional, and Wada, Takashi, additional

Published
2017
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203. P2_17 Association of TNFSF4 Polymorphism with Proteinase 3 - ANCA Positive Vasculitis in a Japanese Population

Author

Iwahashi, Yuka, primary, Kawasaki, Aya, additional, Hirano, Fumio, additional, Sada, Ken-ei, additional, Kobayashi, Shigeto, additional, Yamada, Hidehiro, additional, Furukawa, Hiroshi, additional, Yamagata, Kunihiro, additional, Sumida, Takayuki, additional, Miyasaka, Nobuyuki, additional, Tohma, Shigeto, additional, Ozaki, Shoichi, additional, Matsuo, Seiichi, additional, Hashimoto, Hiroshi, additional, Makino, Hirofumi, additional, Arimura, Yoshihiro, additional, Harigai, Masayoshi, additional, and Tsuchiya, Naoyuki, additional

Published
2017
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207. Re-structuring the Professional Education System of the Nagoya University School of Medicine

Author

SHIMADA, Yasuhiro, UEMURA, Kazumasa, MATSUO, Seiichi, and TAKEZAWA, Jun

Abstract

医学部に課せられた教育に関する目標は、医の倫理を尊重し、人類の幸福に貢献することを誇りとする医学研究者および医療人の育成、にある。近年の生命科学と科学技術の進歩により、医学・医療の知識・技術の量は膨大となり細分化されるようになった。また医学・医療に対する社会のニーズも多様化し、現在の医学教育がこれらにマッチしていないこともしばしば指摘されている。一方、大学院大学への移行により、学部教育に対する時間的制約が大きくなり、もはや１人の教官が教育・研究・診療のすべてをカバーすることは不可能といっても過言でない。また、昨今の医学部の現状では、医学教育はしばしば研究や診療の下位に位置するものとしてとらえられており、インセンティブも決して高いとは言い難い。医学部医学科および附属病院では法人化を前にした中期計画を策定するにあたり、教育に関するヘッドクオータを構築することにより、教育に関する目標を達成できるのではないかと模索してきた。本稿では、医学部医学科におけるこれまでの教育に関する取り組みを紹介し、さらに新たに立ち上がった医学部保健学科を巻き込んだ医系全体の専門職教育の試みについて紹介した。, The goal of medical education in the Nagoya University School of Medicine is to foster medical researchers and medical professionals who respect medical ethics and who are proud of contributing to human welfare. However, medical education itself has been regarded by staff as inferior to research and clinical work, and incentives to teach medical education are low. In the School of Medicine and the University Hospital, we have discussed this problem for a long time and concluded that in order to fulfill the goal of medical education, we have to construct a headquarter for clinical education. The headquarter has started it’s work by developing a curriculum for clinical education common to medical professionals not only in the School of Medicine and the University Hospital but also in the School of Health Sciences.

Published
2004

208. High Levels of Soluble C5b-9 Complex in Dialysis Fluid May Predict Poor Prognosis in Peritonitis in Peritoneal Dialysis Patients

Author

Stover, Cordula M., Mizuno, Masashi, Suzuki, Yasuhiro, Higashide, Keiko, Sei, Yumi, Iguchi, Daiki, Sakata, Fumiko, Horie, Masanobu, Maruyama, Shoichi, Matsuo, Seiichi, Morgan, Bryan, and Ito, Yasuhiko

Subjects
Male, 0301 basic medicine, Microbiological culture, medicine.medical_treatment, 030232 urology & nephrology, lcsh:Medicine, Complement Membrane Attack Complex, Pathology and Laboratory Medicine, Gastroenterology, 0302 clinical medicine, Dialysis Solutions, Abdomen, Medicine and Health Sciences, lcsh:Science, Multidisciplinary, Gram Positive Bacteria, Fungal Diseases, Complement C4, Complement C3, Middle Aged, Prognosis, Soluble C5b-9 complex, Treatment Outcome, Infectious Diseases, Nephrology, Female, Anatomy, Peritoneum, Peritoneal Dialysis, Research Article, Poor prognosis, medicine.medical_specialty, Peritonitis, Microbiology, Peritoneal dialysis, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Medical Dialysis, medicine, Humans, Gram Negative Bacteria, Aged, Retrospective Studies, Dialysis fluid, business.industry, lcsh:R, fungi, Organisms, Fungi, Biology and Life Sciences, Bacteriology, Retrospective cohort study, medicine.disease, Feline infectious peritonitis, Surgery, body regions, 030104 developmental biology, Kidney Failure, Chronic, lcsh:Q, business, Biomarkers
Abstract

Background\ud \ud We searched for indicators to predict the prognosis of infectious peritonitis by measuring levels of complement proteins and activation products in peritoneal dialysis (PD) fluid (PDF) of patients at early stages of peritonitis. We retrospectively analyzed the relationship between the levels of sC5b-9, C3 and C4 in PDF and the subsequent clinical prognosis.\ud \ud Methods\ud \ud We measured levels of sC5b-9, C3 and C4 in PDF on days 1, 2 and 5 post-onset of peritonitis in 104 episodes of infectious peritonitis in PD patients from 2008 and retrospectively compared levels with clinical outcomes. Further analysis for the presence of causative microorganisms or to demonstrate bacterial culture negative peritonitis was performed and correlated with change of levels of sC5b-9 in PDF.\ud \ud Results\ud \ud When PD patients with peritonitis were divided into groups that either failed to recover from peritonitis and were finally withdrawn from PD (group 1; n = 25) or recovered (group 2; n = 79), levels of sC5b-9, C3 and C4 in PDF were significantly higher in group 1 patients compared to those in group 2 on day5. Analysis of microorganisms showed significantly higher sC5b-9 levels in PDF of peritonitis cases caused by culture negative peritonitis in group 1 compared with group 2 when we analyzed for individual microorganisms. Of note, on day5, the sC5b-9 levels in PDF were similarly high in peritonitis caused by fungi or other organisms.\ud \ud Conclusion\ud \ud Our results suggested that levels of complement markers in PDF, especially sC5b-9, have potential as surrogate markers to predict prognosis of PD-related peritonitis.

Published
2017
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209. Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice

Author

Yashima, Akihito, primary, Mizuno, Masashi, additional, Yuzawa, Yukio, additional, Shimada, Koki, additional, Suzuki, Norihiko, additional, Tawada, Hideo, additional, Sato, Waichi, additional, Tsuboi, Naotake, additional, Maruyama, Shoichi, additional, Ito, Yasuhiko, additional, Matsuo, Seiichi, additional, and Ohno, Tamio, additional

Published
2016
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211. International Network of Chronic Kidney Disease cohort studies (iNET-CKD): a global network of chronic kidney disease cohorts

Author

Dienemann, Thomas, primary, Fujii, Naohiko, additional, Orlandi, Paula, additional, Nessel, Lisa, additional, Furth, Susan L., additional, Hoy, Wendy E., additional, Matsuo, Seiichi, additional, Mayer, Gert, additional, Methven, Shona, additional, Schaefer, Franz, additional, Schaeffner, Elke S., additional, Solá, Laura, additional, Stengel, Bénédicte, additional, Wanner, Christoph, additional, Zhang, Luxia, additional, Levin, Adeera, additional, Eckardt, Kai-Uwe, additional, and Feldman, Harold I., additional

Published
2016
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212. Efficacy of urinary midkine as a biomarker in patients with acute kidney injury

Author

Hayashi, Hiroki, primary, Sato, Waichi, additional, Kosugi, Tomoki, additional, Nishimura, Kunihiro, additional, Sugiyama, Daisuke, additional, Asano, Naoko, additional, Ikematsu, Shinya, additional, Komori, Kimihiro, additional, Nishiwaki, Kimitoshi, additional, Kadomatsu, Kenji, additional, Matsuo, Seiichi, additional, Maruyama, Shoichi, additional, and Yuzawa, Yukio, additional

Published
2016
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213. Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers

Author

Imaizumi, Takahiro, primary, Ando, Masahiko, additional, Nakatochi, Masahiro, additional, Maruyama, Shoichi, additional, Yasuda, Yoshinari, additional, Honda, Hiroyuki, additional, Kuwatsuka, Yachiyo, additional, Kato, Sawako, additional, Kondo, Takaaki, additional, Iwata, Masamitsu, additional, Nakashima, Toru, additional, Yasui, Hiroshi, additional, Takamatsu, Hideki, additional, Okajima, Hiroshi, additional, Yoshida, Yasuko, additional, and Matsuo, Seiichi, additional

Published
2016
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214. Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis

Author

Endo, Nobuhide, primary, Tsuboi, Naotake, additional, Furuhashi, Kazuhiro, additional, Shi, Yiqin, additional, Du, Qiuna, additional, Abe, Tomoko, additional, Hori, Mayuko, additional, Imaizumi, Takahiro, additional, Kim, Hangsoo, additional, Katsuno, Takayuki, additional, Ozaki, Takenori, additional, Kosugi, Tomoki, additional, Matsuo, Seiichi, additional, and Maruyama, Shoichi, additional

Published
2016
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215. Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study

Author

Kawasaki, Aya, primary, Hasebe, Narumi, additional, Hidaka, Misaki, additional, Hirano, Fumio, additional, Sada, Ken-ei, additional, Kobayashi, Shigeto, additional, Yamada, Hidehiro, additional, Furukawa, Hiroshi, additional, Yamagata, Kunihiro, additional, Sumida, Takayuki, additional, Miyasaka, Nobuyuki, additional, Tohma, Shigeto, additional, Ozaki, Shoichi, additional, Matsuo, Seiichi, additional, Hashimoto, Hiroshi, additional, Makino, Hirofumi, additional, Arimura, Yoshihiro, additional, Harigai, Masayoshi, additional, and Tsuchiya, Naoyuki, additional

Published
2016
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216. Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2

Author

Nagata, Takanobu, primary, Sobajima, Hiroshi, additional, Ohashi, Norimi, additional, Hirakawa, Akihiro, additional, Katsuno, Takayuki, additional, Yasuda, Yoshinari, additional, Matsuo, Seiichi, additional, Tsuboi, Naotake, additional, and Maruyama, Shoichi, additional

Published
2016
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218. MP485APOPTOSIS INHIBITOR OF MACROPHAGE PROTEIN AMELIORATES FUNGUS-INDUCED PERITONEAL INJURY IN MICE BY UPREGULATION OF CLEARANCE OF NECROTIC DEBRIS

Author

Tomita, Takako, primary, Ito, Yasuhiko, additional, Kitada, Kento, additional, Mizuno, Masashi, additional, Suzuki, Yasuhiro, additional, Sakata, Fumiko, additional, Nakano, Daisuke, additional, Maruyama, Shoichi, additional, Arai, Satoko, additional, Miyazaki, Toru, additional, Nishiyama, Akira, additional, and Matsuo, Seiichi, additional

Published
2016
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224. Vascular Endothelial Cell Injury Is an Important Factor in the Development of Encapsulating Peritoneal Sclerosis in Long-Term Peritoneal Dialysis Patients

Author

Tawada, Mitsuhiro, primary, Ito, Yasuhiko, additional, Hamada, Chieko, additional, Honda, Kazuho, additional, Mizuno, Masashi, additional, Suzuki, Yasuhiro, additional, Sakata, Fumiko, additional, Terabayashi, Takeshi, additional, Matsukawa, Yoshihisa, additional, Maruyama, Shoichi, additional, Imai, Enyu, additional, Matsuo, Seiichi, additional, and Takei, Yoshifumi, additional

Published
2016
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226. Association Between Reappearance of Myeloperoxidase–Antineutrophil Cytoplasmic Antibody and Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis.

Author

Watanabe, Haruki, Sada, Ken‐Ei, Matsumoto, Yoshinori, Harigai, Masayoshi, Amano, Koichi, Dobashi, Hiroaki, Fujimoto, Shouichi, Usui, Joichi, Yamagata, Kunihiro, Atsumi, Tatsuya, Banno, Shogo, Sugihara, Takahiko, Arimura, Yoshihiro, Matsuo, Seiichi, Makino, Hirofumi, Sugiyama, Hitoshi, Takasaki, Yoshinari, Ishizu, Akihiro, Fujii, Takao, and Okada, Yasunori

Subjects
CONFIDENCE intervals, LONGITUDINAL method, MULTIVARIATE analysis, PEROXIDASE, VASCULITIS, DISEASE relapse, GRANULOMATOSIS with polyangiitis, DISEASE remission, CASE-control method, ODDS ratio, ANTINEUTROPHIL cytoplasmic antibodies, BLOOD
Abstract

Objective: To evaluate clinical links between levels of myeloperoxidase (MPO)–antineutrophil cytoplasmic antibody (ANCA) and relapse in patients with ANCA‐associated vasculitis (AAV) using a data set from 2 nationwide prospective cohort studies. Methods: From the cohort studies, MPO‐ANCA–positive patients who achieved remission during the 6 months after remission induction therapy were enrolled. We measured MPO‐ANCA levels at months 0, 3, 6, 12, 18, 24, and at the time of relapse. The primary outcome measure was relapse. A nested case–control analysis and multivariable analysis were performed to investigate the relationship between ANCA reappearance and relapse. Results: Of 271 patients, 183 were classified as having microscopic polyangiitis, 34 as having granulomatosis with polyangiitis, 15 as having eosinophilic granulomatosis with polyangiitis, and 39 were unclassifiable. The median age was 73 years, and 165 (61%) were female. In 195 patients (72%), MPO‐ANCA levels decreased to normal levels within 6 months after commencement of treatment, and MPO‐ANCA reappeared in 73 of 181 patients (40%) with complete follow‐up data. Reappearance of MPO‐ANCA was more frequent in patients with relapse than in 75 age‐ and sex‐matched control patients without relapse (odds ratio 26.2 [95% confidence interval 8.2–101], P < 0.0001) after adjustment for confounding factors. Conclusion: Reappearance of MPO‐ANCA could be a clinically useful biomarker for predicting relapse in patients with MPO‐ANCA–positive AAV in remission. This suggests that routine MPO‐ANCA monitoring should be implemented in this patient population. [ABSTRACT FROM AUTHOR]

Published
2018
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227. Glomerular localization of thrombomodulin in human glomerulonephritis

Author

Mizutani, Motohiro, Yuzawa, Yukio, Maruyama, Ikuro, Sakamoto, Nobuo, and Matsuo, Seiichi

Subjects
systemic lupus erythematosus, Thrombomodulin, membrano-proliferative glomerulonephritis, endothelial injury, glomerulonephritis
Abstract

名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年9月14日 水谷大裕氏の博士論文として提出された

Published
1993

228. Is the new GFR equation using inulin clearance a more accurate method for Asian patients?

Author

Kim, Beom Seok, primary, Lee, Yong Kyu, additional, Choi, Hoon Young, additional, Choi, Seung Ok, additional, Shin, Sug Kyun, additional, Ha, Sung Kyu, additional, Lee, Kang Wook, additional, Kim, Yang Wook, additional, Kim, Yong Lim, additional, Yasuda, Yoshinari, additional, Imai, Enyu, additional, Horio, Masaru, additional, Tomino, Yasuhiko, additional, Matsuo, Seiichi, additional, and Lee, Ho Yung, additional

Published
2015
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233. Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients

Author

Sawai, Akihiro, primary, Yasuda, Yoshinari, additional, Suzuki, Susumu, additional, Ishii, Hideki, additional, Goto, Motomitsu, additional, Kato, Sawako, additional, Hayashi, Mutsuharu, additional, Maruyama, Shoichi, additional, Murohara, Toyoaki, additional, Oiso, Yutaka, additional, and Matsuo, Seiichi, additional

Published
2015
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234. Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse

Author

Yamaguchi, Makoto, primary, Ando, Masahiko, additional, Kato, Sawako, additional, Katsuno, Takayuki, additional, Kato, Noritoshi, additional, Kosugi, Tomoki, additional, Sato, Waichi, additional, Tsuboi, Naotake, additional, Yasuda, Yoshinari, additional, Mizuno, Masashi, additional, Ito, Yasuhiko, additional, Matsuo, Seiichi, additional, and Maruyama, Shoichi, additional

Published
2015
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235. A Prospective Observational Survey on the Long-Term Effect of LDL Apheresis on Drug-Resistant Nephrotic Syndrome

Author

Muso, Eri, primary, Mune, Masatoshi, additional, Hirano, Tsutomu, additional, Hattori, Motoshi, additional, Kimura, Kenjiro, additional, Watanabe, Tsuyoshi, additional, Yokoyama, Hitoshi, additional, Sato, Hiroshi, additional, Uchida, Shunya, additional, Wada, Takashi, additional, Shoji, Tetsuo, additional, Takemura, Tsukasa, additional, Yuzawa, Yukio, additional, Ogahara, Satoru, additional, Sugiyama, Satoshi, additional, Iino, Yasuhiko, additional, Sakai, Soichi, additional, Ogura, Yousuke, additional, Yukawa, Susumu, additional, Nishizawa, Yoshiki, additional, Yorioka, Noriaki, additional, Imai, Enyu, additional, Matsuo, Seiichi, additional, and Saito, Takao, additional

Published
2015
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236. Midkine Regulates BP through Cytochrome P450–Derived Eicosanoids

Author

Sato, Yuka, primary, Sato, Waichi, additional, Maruyama, Shoichi, additional, Wilcox, Christopher S., additional, Falck, John R., additional, Masuda, Tomohiro, additional, Kosugi, Tomoki, additional, Kojima, Hiroshi, additional, Maeda, Kayaho, additional, Furuhashi, Kazuhiro, additional, Ando, Masahiko, additional, Imai, Enyu, additional, Matsuo, Seiichi, additional, and Kadomatsu, Kenji, additional

Published
2015
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238. Clinical Impact of Kidney Function on Presepsin Levels

Author

Nagata, Takanobu, primary, Yasuda, Yoshinari, additional, Ando, Masahiko, additional, Abe, Tomoko, additional, Katsuno, Takayuki, additional, Kato, Sawako, additional, Tsuboi, Naotake, additional, Matsuo, Seiichi, additional, and Maruyama, Shoichi, additional

Published
2015
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244. The efficacy of tolvaptan as a diuretic for chronic kidney disease patients

Author

Tanaka, Akihito, primary, Katsuno, Takayuki, additional, Ozaki, Takenori, additional, Sakata, Fumiko, additional, Kato, Noritoshi, additional, Suzuki, Yasuhiro, additional, Kosugi, Tomoki, additional, Kato, Sawako, additional, Tsuboi, Naotake, additional, Sato, Waichi, additional, Yasuda, Yoshinari, additional, Mizuno, Masashi, additional, Ito, Yasuhiko, additional, Matsuo, Seiichi, additional, and Maruyama, Shoichi, additional

Published
2015
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245. Identification of an Interaction between VWF rs7965413 and Platelet Count as a Novel Risk Marker for Metabolic Syndrome: An Extensive Search of Candidate Polymorphisms in a Case-Control Study

Author

Nakatochi, Masahiro, primary, Ushida, Yasunori, additional, Yasuda, Yoshinari, additional, Yoshida, Yasuko, additional, Kawai, Shun, additional, Kato, Ryuji, additional, Nakashima, Toru, additional, Iwata, Masamitsu, additional, Kuwatsuka, Yachiyo, additional, Ando, Masahiko, additional, Hamajima, Nobuyuki, additional, Kondo, Takaaki, additional, Oda, Hiroaki, additional, Hayashi, Mutsuharu, additional, Kato, Sawako, additional, Yamaguchi, Makoto, additional, Maruyama, Shoichi, additional, Matsuo, Seiichi, additional, and Honda, Hiroyuki, additional

Published
2015
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248. Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome.

Author

Saito, Takao, Iwano, Masayuki, Matsumoto, Koichi, Mitarai, Tetsuya, Yokoyama, Hitoshi, Yorioka, Noriaki, Nishi, Shinichi, Yoshimura, Ashio, Sato, Hiroshi, Ogahara, Satoru, Sasatomi, Yoshie, Kataoka, Yasufumi, Ueda, Shiro, Koyama, Akio, Maruyama, Shoichi, Nangaku, Masaomi, Imai, Enyu, Matsuo, Seiichi, and Tomino, Yasuhiko

Subjects
KIDNEY disease treatments, STEROID drugs, COMBINATION drug therapy, BLOOD testing, RANDOMIZED controlled trials, LONGITUDINAL method
Abstract

Background: We designed a prospective and randomized trial of mizoribine (MZR) therapy combined with prednisolone (PSL) for idiopathic membranous nephropathy (IMN) with steroid-resistant nephrotic syndrome (SRNS). Methods: Patients with IMN were divided into 2 groups, and MZR combined with PSL was administered for 2 years. PSL was initially prescribed at 40 mg/day and tapered. MZR was given once-a-day at 150 mg and 3-times-a-day at 50 mg each to groups 1 and 2. Serum MZR concentrations from 0 to 4 h after administration were examined within one month of treatment. The concentration curve and peak serum level ( C ) of MZR were estimated by the population pharmacokinetic (PPK) parameters of MZR. Results: At 2 years, 10 of 19 patients (52.6 %) in group 1 and 7 of 18 patients (38.9 %) in group 2 achieved complete remission (CR). The time-to-remission curve using the Kaplan-Meier technique revealed an increase in the cumulative CR rate in group 1, but no significant difference between the groups. Meanwhile, there was a significant difference in C between groups 1 and 2 (mean ± SD: 1.20 ± 0.52 vs. 0.76 ± 0.39 μg/mL, p = 0.04), and C levels in CR cases were significantly higher than those in non-CR cases. Receiver operating characteristic analysis showed that C more than 1.1 µg/mL was necessary for CR in once-a-day administration. Conclusion: Administration of MZR once a day is useful when combined with PSL for treatment of IMN with SRNS. In addition, it is important to assay the serum concentration of MZR and to determine C , and more than 1.1 µg/mL of C is necessary for CR. [ABSTRACT FROM AUTHOR]

Published
2017
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249. Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice.

Author

Mizuno, Masashi, Ito, Yasuhiko, Yashima, Akihito, Suzuki, Norihiko, Tawada, Hideo, Sato, Waichi, Tsuboi, Naotake, Maruyama, Shoichi, Matsuo, Seiichi, Yuzawa, Yukio, Shimada, Koki, and Ohno, Tamio

Subjects
MALARIA, GLOMERULONEPHRITIS, KIDNEY diseases, PLASMODIUM, NEPHROTIC syndrome treatment, INFECTIOUS disease transmission
Abstract

Background: Malaria is an important tropical disease and has remained a serious health problem in many countries. One of the critical complications of malarial infection is renal injury, such as acute renal failure and chronic glomerulopathy. Few animal models of nephropathy related to malarial infection have been reported. Therefore, we developed and investigated a novel malarial nephropathy model in mice infected by murine malaria parasites. Methods: NC mice and C57BL/6J mice were infected with Ttwo different murine malaria parasites, Plasmodium ( P.) chabaudi AS and P. yoelii 17X. After the infection, renal pathology and blood and urinary biochemistry were analyzed. Results: NC mice infected by the murine malaria parasite P. chabaudi AS, but not P. yoelii 17X, developed mesangial proliferative glomerulonephritis with endothelial damage, and decreased serum albumin concentration and increased proteinuria. These pathological changes were accompanied by deposition of immunoglobulin G and complement component 3, mainly in the mesangium until day 4 and in the mesangium and glomerular capillaries from day 8. On day 21, renal pathology developed to focal segmental sclerosis according to light microscopy. In C57BL/6J mice, renal injuries were not observed from either parasite infection. Conclusion: The clinical and pathological features of P. chabaudi AS infection in NC mice might be similar to quartan malarial nephropathy resulting from human malaria parasite P. malariae infection. The NC mouse model might therefore be useful in analyzing the underlying mechanisms and developing therapeutic approaches to malaria-related nephropathy. [ABSTRACT FROM AUTHOR]

Published
2017
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