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1,299 results on '"McCullough, Arthur"'

202. Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis.

Author

Sanyal, Arun, Sanyal, Arun, Kowdley, Kris, Terrault, Norah, Chalasani, Naga, Abdelmalek, Manal, McCullough, Arthur, Shringarpure, Reshma, Ferguson, Beatrice, Lee, Lois, Chen, Jianfen, Liberman, Alexander, Shapiro, David, Neuschwander-Tetri, Brent, Loomba, Rohit, Sanyal, Arun, Sanyal, Arun, Kowdley, Kris, Terrault, Norah, Chalasani, Naga, Abdelmalek, Manal, McCullough, Arthur, Shringarpure, Reshma, Ferguson, Beatrice, Lee, Lois, Chen, Jianfen, Liberman, Alexander, Shapiro, David, Neuschwander-Tetri, Brent, and Loomba, Rohit

Abstract

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a leading cause of liver transplantation, and many trials are underway to evaluate potential therapies. The farnesoid X receptor ligand obeticholic acid in the NASH treatment trial evaluated the effects of obeticholic acid vs placebo on histologic response (defined as decrease in nonalcoholic fatty liver disease activity score [NAS] by ≥2, with no worsening of fibrosis); 45% of patients had a histologic response to obeticholic acid (25 mg), and 21% had a response to placebo (P < .01). We performed a secondary analysis of data from this trial to identify clinical parameters associated with a histologic response. METHODS: We used a logistic regression model with a stepwise selection procedure to identify baseline and early on-treatment factors associated with a histologic response at 72 weeks. Baseline demographics, liver histology, medical history, concomitant medications, cardiometabolic parameters, and serum biochemistry, as well as the changes over the course of the trial (at weeks 12 and 24), were evaluated as potential predictors of a histologic response. The model was cross-validated by a jackknife method, and performance was evaluated with the area under the receiver operating characteristic curve. RESULTS: The logistic regression model found that obeticholic acid treatment, baseline NAS > 5, baseline triglyceride level ≤ 154 mg/dL, baseline international normalized ratio ≤ 1, baseline aspartate aminotransferase level ≤ 49 U/L, and a decrease in alanine aminotransferase level at week 24 by 17 U/L or more, to be significantly associated with histologic response (area under the receiver operating characteristic curve, 0.83; 95% confidence interval, 0.77-0.89; P < .0001). CONCLUSIONS: In a secondary analysis of data from a clinical trial of obeticholic acid in patients with NASH, we identified routine clinical and laboratory parameters during the first 24 weeks of treatment (such as baseline N

Published
2019

204. Quantification of carbohydrate oxidation by respiratory gas exchange and isotopic tracers

Author

Glamour, Tejinder S., McCullough, Arthur J., Sauer, Pieter J.J., and Kalhan, Satish C.

Subjects
Carbohydrate metabolism -- Research, Calorimetry -- Methods, Biological sciences
Abstract

An estimation of carbohydrate oxidation using indirect respiratory calorimetry and (U-13C) isotopic glucose tracer is carried out and compared as a function of respiratory exchange ratio, (RER), varying between 0.7 to 1.04, in 14 studies conducted on 9 healthy adult subjects. It was seen that the results were similar only when the value of the nonprotein respiratory quotient (NPRQ) lay in the (0.76 - 0.90) range.

Published
1995

215. HDL flux is higher in patients with nonalcoholic fatty liver disease

Author

McCullough, Arthur, primary, Previs, Stephen F., additional, Dasarathy, Jaividhya, additional, Lee, Kwangwon, additional, Osme, Abdullah, additional, Kim, Chunki, additional, Ilchenko, Serguei, additional, Lorkowski, Shuhui W., additional, Smith, Jonathan D., additional, Dasarathy, Srinivasan, additional, and Kasumov, Takhar, additional

Published
2019
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226. Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis

Author

Saha, Banishree, primary, Tornai, David, additional, Kodys, Karen, additional, Adejumo, Adeyinka, additional, Lowe, Patrick, additional, McClain, Craig, additional, Mitchell, Mack, additional, McCullough, Arthur, additional, Dasarathy, Srinivasan, additional, Kroll‐Desrosiers, Aimee, additional, Barton, Bruce, additional, Radaeva, Svetlana, additional, and Szabo, Gyongyi, additional

Published
2019
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237. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Author

Schugar, Rebecca C., Shih, Diana M., Warrier, Manya, Helsley, Robert N., Burrows, Amy, Ferguson, Daniel, Brown, Amanda L., Gromovsky, Anthony D., Heine, Markus, Chatterjee, Arunachal, Li, Lin, Li, Xinmin S., Wang, Zeneng, Willard, Belinda, Meng, YongHong, Kim, Hanjun, Che, Nam, Pan, Calvin, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Morton, Richard E., Langefeld, Carl D., Das, Swapan K., Rudel, Lawrence L., Zein, Nizar, McCullough, Arthur J., Dasarathy, Srinivasan, Tang, W.H. Wilson, Erokwu, Bernadette O., Flask, Chris A., Laakso, Markku, Civelek, Mete, Naga Prasad, Sathyamangla V., Heeren, Joerg, Lusis, Aldons J., Hazen, Stanley L., and Brown, J. Mark

Published
2017
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243. Multicenter Validation of Association Between Decline in MRI‐PDFF and Histologic Response in NASH.

Author

Loomba, Rohit, Neuschwander‐Tetri, Brent A, Sanyal, Arun, Chalasani, Naga, Diehl, Anna Mae, Terrault, Norah, Kowdley, Kris, Dasarathy, Srinivasan, Kleiner, David, Behling, Cynthia, Lavine, Joel, Van Natta, Mark, Middleton, Michael, Tonascia, James, Sirlin, Claude, Allende, Daniela, McCullough, Arthur J., Penumatsa, Revathi, Dasarathy, Jaividhya, and Lavine, Joel E.

Published
2020
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244. Hospital readmission following transjugular intrahepatic portosystemic shunt: a 14-year single-center experience.

Author

Vozzo, Catherine F, Singh, Tavankit, Bullen, Jennifer, Sarvepalli, Shashank, McCullough, Arthur, and Kapoor, Baljendra

Subjects
SURGICAL anastomosis, PATIENT readmissions, MEDICAL centers
Abstract

Background Placement of a transjugular intrahepatic portosystemic shunt (TIPS) is a relatively common procedure used to treat complications of portal hypertension. However, only limited data exist regarding the hospital-readmission rate after TIPS placement and no studies have addressed the causes of hospital readmission. We therefore sought to identify the 30-day hospital-readmission rate after TIPS placement at our institution and to determine potential causes and predictors of readmission. Methods We reviewed our electronic medical-records system at our institution between 2004 and 2017 to identify patients who had undergone primary TIPS placement with polytetrafluoroethylene-covered stents and to determine the 30-day readmission rate among these patients. A series of univariable logistic-regression models were fit to assess potential predictors of 30-day readmission. Results A total of 566 patients were included in the analysis. The 30-day readmission rate after TIPS placement was 36%. The most common causes for readmission were confusion (48%), infection (15%), bleeding (11%), and fluid overload (7%). A higher Model for End-Stage Liver Disease (MELD) score corresponded with a higher rate of readmission (odds ratio associated with each 1-unit increase in MELD score: 1.06; 95% confidence interval: 1.02–1.09; P  =   0.001). Other potential predictors, including indication for TIPS placement, were not significantly associated with a higher readmission rate. Conclusions The 30-day readmission rate after TIPS placement with covered stents is high, with nearly half of these readmissions due to hepatic encephalopathy—a known complication of TIPS placement. Novel interventions to help reduce the TIPS readmission rate should be prioritized in future research. [ABSTRACT FROM AUTHOR]

Published
2020
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249. Trends and Risk Factors for 30-Day Readmissions in Patients With Acute Cholangitis: Analysis From the National Readmission Database: Presidential Poster Award

Author

Parikh, Malav P., primary, Sarvepalli, Shashank, additional, Gupta, Niyati M., additional, Lopez, Rocio, additional, Bhatt, Amit, additional, Chahal, Prabhleen, additional, Jang, Sunguk, additional, Stevens, Tyler, additional, Vargo, John J., additional, Thota, Prasanthi N., additional, McCullough, Arthur, additional, and Sanaka, Madhusudhan R., additional

Published
2018
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