4,218 results on '"Miller, Timothy"'
Search Results
202. Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds.
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Ren, Xiaoyan, Zhou, Qi, Foulad, David, Tiffany, Aleczandria S, Dewey, Marley J, Bischoff, David, Miller, Timothy A, Reid, Russell R, He, Tong-Chuan, Yamaguchi, Dean T, Harley, Brendan AC, and Lee, Justine C
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Bone Regeneration ,Bone Resorption ,Bone and Bones ,Calcification ,Physiologic ,Cell Differentiation ,Chondroitin Sulfates ,Coculture Techniques ,Collagen Type I ,Cross-Linking Reagents ,Gene Expression ,Glycosaminoglycans ,Humans ,Mesenchymal Stem Cells ,Osteoclasts ,Osteogenesis ,Osteoprotegerin ,Primary Cell Culture ,Tissue Engineering ,Tissue Scaffolds ,Transgenes ,Calcification ,Physiologic - Abstract
The instructive capabilities of extracellular matrix-inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment. We previously demonstrated that nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffolds efficiently induced osteoprogenitor differentiation and bone healing. In this work, we combined adenovirus-mediated delivery of osteoprotegerin (AdOPG), an endogenous anti-osteoclastogenic decoy receptor, in primary human mesenchymal stem cells (hMSCs) with MC-GAG to understand the role of osteoclast inactivation in augmentation of bone regeneration. Simultaneous differentiation of osteoprogenitors on MC-GAG and osteoclast progenitors resulted in bidirectional positive regulation. AdOPG expression did not affect osteogenic differentiation alone. In the presence of both cell types, AdOPG-transduced hMSCs on MC-GAG diminished osteoclast-mediated resorption in direct contact; however, osteoclast-mediated augmentation of osteogenic differentiation was unaffected. Thus, the combination of OPG with MC-GAG may represent a method for uncoupling osteogenic and osteoclastogenic differentiation to augment bone regeneration.
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- 2019
203. Nanoparticulate mineralized collagen glycosaminoglycan materials directly and indirectly inhibit osteoclastogenesis and osteoclast activation
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Ren, Xiaoyan, Zhou, Qi, Foulad, David, Dewey, Marley J, Bischoff, David, Miller, Timothy A, Yamaguchi, Dean T, Harley, Brendan AC, and Lee, Justine C
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Engineering ,Biomedical Engineering ,Dental/Oral and Craniofacial Disease ,Stem Cell Research ,Stem Cell Research - Nonembryonic - Human ,Regenerative Medicine ,Musculoskeletal ,Cell Differentiation ,Cell Proliferation ,Cell Survival ,Collagen ,Glycosaminoglycans ,Humans ,MAP Kinase Signaling System ,Mesenchymal Stem Cells ,Nanoparticles ,Osteoclasts ,bone regeneration ,bone resorption ,collagen glycosaminoglycan ,nanoparticle ,osteoclast ,osteoprotegerin ,Clinical Sciences ,Medical Physiology ,Biomedical engineering - Abstract
The ability of the extracellular matrix (ECM) to direct cell fate has generated the potential for developing a materials-only strategy for tissue regeneration. Previously, we described a nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) material that efficiently induced osteogenic differentiation of human mesenchymal stem cells (hMSCs) and calvarial bone healing without exogenous growth factors or progenitor cell expansion. In this work, we evaluated the interactions between MC-GAG and primary human osteoclasts (hOCs). In the absence of hMSCs, mineralized Col-GAG materials directly inhibited hOC viability, proliferation, and resorption in contrast to nonmineralized Col-GAG, which demonstrated a modest inhibition of resorptive activity only. Cocultures containing differentiating hMSCs with hOCs demonstrated increased hOC-mediated resorption only on Col-GAG while MC-GAG cocultures continued to inhibit resorption. Unlike Col-GAG, hMSCs on MC-GAG expressed increased amounts of osteoprotegerin (OPG) protein, the major endogenous osteoclast inhibitor. Interestingly, OPG expression was found to be antagonized by small mothers against decapentaplegic1/5 (Smad1/5) phosphorylation, an obligate pathway for osteogenic differentiation of hMSCs on MC-GAG, and potentiated by extracellular signal-regulated kinase (ERK1/2) phosphorylation. Collectively, these results suggested that the MC-GAG material both directly inhibited the osteoclast viability, proliferation, and resorptive activity as well as induced hMSCs to secrete osteoprotegerin, an antiosteoclastogenic factor, via a signalling pathway distinct from osteogenic differentiation.
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- 2019
204. Stress Fractures of the Tibia
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Harris, Joshua D., Varner, Kevin E., Miller, Timothy L., Miller, Timothy L., editor, and Kaeding, Christopher C., editor
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- 2020
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205. Stress Fractures of the Pelvis and Sacrum
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Altintas, Burak, Miller, Timothy L., Ireland, Mary Lloyd, Miller, Timothy L., editor, and Kaeding, Christopher C., editor
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- 2020
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206. Stress Fractures of the Ribs and Shoulder Girdle
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Dibartola, Alex C., Cvetanovich, Gregory L., Miller, Timothy L., Miller, Timothy L., editor, and Kaeding, Christopher C., editor
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- 2020
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207. The Holistic Approach to Stress Fracture Treatment
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Miller, Timothy L., Miller, Timothy L., editor, and Kaeding, Christopher C., editor
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- 2020
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208. Classification of Stress Fractures
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Kaeding, Christopher C., Miller, Timothy L., Miller, Timothy L., editor, and Kaeding, Christopher C., editor
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- 2020
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209. For Reservists at the Air Force Space Technology Center, it's ... an out-of-this-world assignment
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Miller, Timothy N.
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AIR FORCE WEAPONS LABORATORY ,RESERVE FORCES - Air Force - United States - Abstract
illus
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- 1990
210. A simple neural vector space model for medical concept normalization using concept embeddings
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Xu, Dongfang and Miller, Timothy
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- 2022
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211. Pain management, fluid therapy and thromboprophylaxis after pancreatoduodenectomy: a worldwide survey among surgeons
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Groen, Jesse V., Henrar, Rutger B., Hanna Sawires, Randa G., AlEassa, Essa, Martini, Chris H., Bonsing, Bert A., Vahrmeijer, Alexander L., Besselink, Marc G., Pecorelli, Nicolo, Hackert, Thilo, Ishizawa, Takeaki, Miller, Timothy, Mungroop, Timothy H., Samra, Jaswinder, Sauvanet, Alain, Adham, Mustapha, Demartines, Nicolas, Christophi, Chris, Morris-Stiff, Gareth, and Mieog, J. Sven D.
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- 2022
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212. Disentangling glial diversity in peripheral nerves at single-nuclei resolution
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Yim, Aldrin K. Y., Wang, Peter L., Bermingham, Jr, John R., Hackett, Amber, Strickland, Amy, Miller, Timothy M., Ly, Cindy, Mitra, Robi D., and Milbrandt, Jeffrey
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- 2022
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213. Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD
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Krishnan, Gopinath, Raitcheva, Denitza, Bartlett, Daniel, Prudencio, Mercedes, McKenna-Yasek, Diane M., Douthwright, Catherine, Oskarsson, Björn E., Ladha, Shafeeq, King, Oliver D., Barmada, Sami J., Miller, Timothy M., Bowser, Robert, Watts, Jonathan K., Petrucelli, Leonard, Brown, Robert H., Kankel, Mark W., and Gao, Fen-Biao
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- 2022
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214. The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
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Opie-Martin, Sarah, Iacoangeli, Alfredo, Topp, Simon D., Abel, Olubunmi, Mayl, Keith, Mehta, Puja R., Shatunov, Aleksey, Fogh, Isabella, Bowles, Harry, Limbachiya, Naomi, Spargo, Thomas P., Al-Khleifat, Ahmad, Williams, Kelly L., Jockel-Balsarotti, Jennifer, Bali, Taha, Self, Wade, Henden, Lyndal, Nicholson, Garth A., Ticozzi, Nicola, McKenna-Yasek, Diane, Tang, Lu, Shaw, Pamela J., Chio, Adriano, Ludolph, Albert, Weishaupt, Jochen H., Landers, John E., Glass, Jonathan D., Mora, Jesus S., Robberecht, Wim, Damme, Philip Van, McLaughlin, Russell, Hardiman, Orla, van den Berg, Leonard, Veldink, Jan H., Corcia, Phillippe, Stevic, Zorica, Siddique, Nailah, Silani, Vincenzo, Blair, Ian P., Fan, Dong-sheng, Esselin, Florence, de la Cruz, Elisa, Camu, William, Basak, Nazli A., Siddique, Teepu, Miller, Timothy, Brown, Robert H., Al-Chalabi, Ammar, and Shaw, Christopher E.
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- 2022
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215. Stress Fractures in Sport: Shoulder
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DiBartola, Alex C., Cvetanovich, Gregory L., Miller, Timothy L., Robertson, Greg A. J., editor, and Maffuli, Nicola, editor
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- 2021
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216. Stress Fracture Injuries in Sport
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Miller, Timothy L., Kaeding, Christopher C., Robertson, Greg A. J., editor, and Maffuli, Nicola, editor
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- 2021
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217. Wireless wearables for postoperative surveillance on surgical wards: a survey of 1158 anaesthesiologists in Western Europe and the USA
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Biais, Matthieu, Bonhomme, Vincent, Buhre, Wolfgang, Cholley, Bernard, Constantin, Jean-Michel, Futier, Emmanuel, Jaber, Samir, Leone, Marc, Preckel, Benedikt, Reuter, Daniel, Schoettker, Patrick, Scheeren, Thomas, Sander, Michael, Steiner, Luzius A., Treskatsch, Sascha, Zacharowski, Kai, Afonso, Anoushka, Arora, Lovkesh, Ault, Michael L., Bartels, Karsten, Brown, Charles, Brown, Daniel, Colquhoun, Douglas, Fink, Ryan, Gan, Tong J., Hanson, Neil, Hyder, Omar, Miller, Timothy, McEvoy, Matt, Pearl, Ronald, Pirracchio, Romain, Popovich, Marc, Satyapriya, Sree, Segal, B. Scott, Williams, George, Michard, Frederic, Thiele, Robert H., Saugel, Bernd, Joosten, Alexandre, Flick, Moritz, and Khanna, Ashish K.
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- 2022
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218. Error Reduction and Diagnostic Concordance in Breast Pathology
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Miller, Timothy Isaac, Flanagan, Meghan R., Lowry, Kathryn P., and Kilgore, Mark R.
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- 2022
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219. Nanoscale spectroscopic imaging of phase separation in a correlated material by resonant X-ray holography
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Vidas, Luciana, Günther, Christian M., Miller, Timothy A., Pfau, Bastian., Schneider, Michael, Guehrs, Erik, Marvel, Robert E., Hallman, Kent A., Haglund Jr, Richard F., Eisebitt, Stefan, and Wall, Simon
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Nanoscale phase coexistence and inhomogeneity are ubiquitous in correlated electron materials, existing in doped Mott insulators, manganites, and high-temperature superconductors. The small length scales and lack of contrast mechanisms make it extremely challenging to measure real-space images of the phase coexistence with high resolution. Yet, images aid our understanding of how phase coexistence and domain boundaries dictate the exotic material properties. Here we show that resonant soft-X-ray holography, previously employed to image magnetic domains, can be used to image phase separation on the nanoscale. We observe nucleation and growth of nanometre-sized metallic domains out of the insulating phase of the prototypical correlated material VO2, using linearly polarized coherent synchrotron radiation. By spectrally resolving the holograms, we extract differential soft X-ray absorption spectra with 50 nm spatial resolution. Furthermore, when combined with ultra-bright and ultra-short X-ray sources, X-ray holography could capture both nanoscale spatial variations and temporal fluctuations that occur close to the transition temperatures or are induced by femtosecond light pulses that cannot be observed with alternative imaging methods., Comment: 4 pages 4 figures
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- 2016
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220. The DESI Experiment Part I: Science,Targeting, and Survey Design
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DESI Collaboration, Aghamousa, Amir, Aguilar, Jessica, Ahlen, Steve, Alam, Shadab, Allen, Lori E., Prieto, Carlos Allende, Annis, James, Bailey, Stephen, Balland, Christophe, Ballester, Otger, Baltay, Charles, Beaufore, Lucas, Bebek, Chris, Beers, Timothy C., Bell, Eric F., Bernal, José Luis, Besuner, Robert, Beutler, Florian, Blake, Chris, Bleuler, Hannes, Blomqvist, Michael, Blum, Robert, Bolton, Adam S., Briceno, Cesar, Brooks, David, Brownstein, Joel R., Buckley-Geer, Elizabeth, Burden, Angela, Burtin, Etienne, Busca, Nicolas G., Cahn, Robert N., Cai, Yan-Chuan, Cardiel-Sas, Laia, Carlberg, Raymond G., Carton, Pierre-Henri, Casas, Ricard, Castander, Francisco J., Cervantes-Cota, Jorge L., Claybaugh, Todd M., Close, Madeline, Coker, Carl T., Cole, Shaun, Comparat, Johan, Cooper, Andrew P., Cousinou, M. -C., Crocce, Martin, Cuby, Jean-Gabriel, Cunningham, Daniel P., Davis, Tamara M., Dawson, Kyle S., de la Macorra, Axel, De Vicente, Juan, Delubac, Timothée, Derwent, Mark, Dey, Arjun, Dhungana, Govinda, Ding, Zhejie, Doel, Peter, Duan, Yutong T., Ealet, Anne, Edelstein, Jerry, Eftekharzadeh, Sarah, Eisenstein, Daniel J., Elliott, Ann, Escoffier, Stéphanie, Evatt, Matthew, Fagrelius, Parker, Fan, Xiaohui, Fanning, Kevin, Farahi, Arya, Farihi, Jay, Favole, Ginevra, Feng, Yu, Fernandez, Enrique, Findlay, Joseph R., Finkbeiner, Douglas P., Fitzpatrick, Michael J., Flaugher, Brenna, Flender, Samuel, Font-Ribera, Andreu, Forero-Romero, Jaime E., Fosalba, Pablo, Frenk, Carlos S., Fumagalli, Michele, Gaensicke, Boris T., Gallo, Giuseppe, Garcia-Bellido, Juan, Gaztanaga, Enrique, Fusillo, Nicola Pietro Gentile, Gerard, Terry, Gershkovich, Irena, Giannantonio, Tommaso, Gillet, Denis, Gonzalez-de-Rivera, Guillermo, Gonzalez-Perez, Violeta, Gott, Shelby, Graur, Or, Gutierrez, Gaston, Guy, Julien, Habib, Salman, Heetderks, Henry, Heetderks, Ian, Heitmann, Katrin, Hellwing, Wojciech A., Herrera, David A., Ho, Shirley, Holland, Stephen, Honscheid, Klaus, Huff, Eric, Hutchinson, Timothy A., Huterer, Dragan, Hwang, Ho Seong, Laguna, Joseph Maria Illa, Ishikawa, Yuzo, Jacobs, Dianna, Jeffrey, Niall, Jelinsky, Patrick, Jennings, Elise, Jiang, Linhua, Jimenez, Jorge, Johnson, Jennifer, Joyce, Richard, Jullo, Eric, Juneau, Stéphanie, Kama, Sami, Karcher, Armin, Karkar, Sonia, Kehoe, Robert, Kennamer, Noble, Kent, Stephen, Kilbinger, Martin, Kim, Alex G., Kirkby, David, Kisner, Theodore, Kitanidis, Ellie, Kneib, Jean-Paul, Koposov, Sergey, Kovacs, Eve, Koyama, Kazuya, Kremin, Anthony, Kron, Richard, Kronig, Luzius, Kueter-Young, Andrea, Lacey, Cedric G., Lafever, Robin, Lahav, Ofer, Lambert, Andrew, Lampton, Michael, Landriau, Martin, Lang, Dustin, Lauer, Tod R., Goff, Jean-Marc Le, Guillou, Laurent Le, Van Suu, Auguste Le, Lee, Jae Hyeon, Lee, Su-Jeong, Leitner, Daniela, Lesser, Michael, Levi, Michael E., L'Huillier, Benjamin, Li, Baojiu, Liang, Ming, Lin, Huan, Linder, Eric, Loebman, Sarah R., Lukić, Zarija, Ma, Jun, MacCrann, Niall, Magneville, Christophe, Makarem, Laleh, Manera, Marc, Manser, Christopher J., Marshall, Robert, Martini, Paul, Massey, Richard, Matheson, Thomas, McCauley, Jeremy, McDonald, Patrick, McGreer, Ian D., Meisner, Aaron, Metcalfe, Nigel, Miller, Timothy N., Miquel, Ramon, Moustakas, John, Myers, Adam, Naik, Milind, Newman, Jeffrey A., Nichol, Robert C., Nicola, Andrina, da Costa, Luiz Nicolati, Nie, Jundan, Niz, Gustavo, Norberg, Peder, Nord, Brian, Norman, Dara, Nugent, Peter, O'Brien, Thomas, Oh, Minji, Olsen, Knut A. G., Padilla, Cristobal, Padmanabhan, Hamsa, Padmanabhan, Nikhil, Palanque-Delabrouille, Nathalie, Palmese, Antonella, Pappalardo, Daniel, Pâris, Isabelle, Park, Changbom, Patej, Anna, Peacock, John A., Peiris, Hiranya V., Peng, Xiyan, Percival, Will J., Perruchot, Sandrine, Pieri, Matthew M., Pogge, Richard, Pollack, Jennifer E., Poppett, Claire, Prada, Francisco, Prakash, Abhishek, Probst, Ronald G., Rabinowitz, David, Raichoor, Anand, Ree, Chang Hee, Refregier, Alexandre, Regal, Xavier, Reid, Beth, Reil, Kevin, Rezaie, Mehdi, Rockosi, Constance M., Roe, Natalie, Ronayette, Samuel, Roodman, Aaron, Ross, Ashley J., Ross, Nicholas P., Rossi, Graziano, Rozo, Eduardo, Ruhlmann-Kleider, Vanina, Rykoff, Eli S., Sabiu, Cristiano, Samushia, Lado, Sanchez, Eusebio, Sanchez, Javier, Schlegel, David J., Schneider, Michael, Schubnell, Michael, Secroun, Aurélia, Seljak, Uros, Seo, Hee-Jong, Serrano, Santiago, Shafieloo, Arman, Shan, Huanyuan, Sharples, Ray, Sholl, Michael J., Shourt, William V., Silber, Joseph H., Silva, David R., Sirk, Martin M., Slosar, Anze, Smith, Alex, Smoot, George F., Som, Debopam, Song, Yong-Seon, Sprayberry, David, Staten, Ryan, Stefanik, Andy, Tarle, Gregory, Tie, Suk Sien, Tinker, Jeremy L., Tojeiro, Rita, Valdes, Francisco, Valenzuela, Octavio, Valluri, Monica, Vargas-Magana, Mariana, Verde, Licia, Walker, Alistair R., Wang, Jiali, Wang, Yuting, Weaver, Benjamin A., Weaverdyck, Curtis, Wechsler, Risa H., Weinberg, David H., White, Martin, Yang, Qian, Yeche, Christophe, Zhang, Tianmeng, Zhao, Gong-Bo, Zheng, Yi, Zhou, Xu, Zhou, Zhimin, Zhu, Yaling, Zou, Hu, and Zu, Ying
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
DESI (Dark Energy Spectroscopic Instrument) is a Stage IV ground-based dark energy experiment that will study baryon acoustic oscillations (BAO) and the growth of structure through redshift-space distortions with a wide-area galaxy and quasar redshift survey. To trace the underlying dark matter distribution, spectroscopic targets will be selected in four classes from imaging data. We will measure luminous red galaxies up to $z=1.0$. To probe the Universe out to even higher redshift, DESI will target bright [O II] emission line galaxies up to $z=1.7$. Quasars will be targeted both as direct tracers of the underlying dark matter distribution and, at higher redshifts ($ 2.1 < z < 3.5$), for the Ly-$\alpha$ forest absorption features in their spectra, which will be used to trace the distribution of neutral hydrogen. When moonlight prevents efficient observations of the faint targets of the baseline survey, DESI will conduct a magnitude-limited Bright Galaxy Survey comprising approximately 10 million galaxies with a median $z\approx 0.2$. In total, more than 30 million galaxy and quasar redshifts will be obtained to measure the BAO feature and determine the matter power spectrum, including redshift space distortions.
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- 2016
221. The DESI Experiment Part II: Instrument Design
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DESI Collaboration, Aghamousa, Amir, Aguilar, Jessica, Ahlen, Steve, Alam, Shadab, Allen, Lori E., Prieto, Carlos Allende, Annis, James, Bailey, Stephen, Balland, Christophe, Ballester, Otger, Baltay, Charles, Beaufore, Lucas, Bebek, Chris, Beers, Timothy C., Bell, Eric F., Bernal, José Luis, Besuner, Robert, Beutler, Florian, Blake, Chris, Bleuler, Hannes, Blomqvist, Michael, Blum, Robert, Bolton, Adam S., Briceno, Cesar, Brooks, David, Brownstein, Joel R., Buckley-Geer, Elizabeth, Burden, Angela, Burtin, Etienne, Busca, Nicolas G., Cahn, Robert N., Cai, Yan-Chuan, Cardiel-Sas, Laia, Carlberg, Raymond G., Carton, Pierre-Henri, Casas, Ricard, Castander, Francisco J., Cervantes-Cota, Jorge L., Claybaugh, Todd M., Close, Madeline, Coker, Carl T., Cole, Shaun, Comparat, Johan, Cooper, Andrew P., Cousinou, M. -C., Crocce, Martin, Cuby, Jean-Gabriel, Cunningham, Daniel P., Davis, Tamara M., Dawson, Kyle S., de la Macorra, Axel, De Vicente, Juan, Delubac, Timothée, Derwent, Mark, Dey, Arjun, Dhungana, Govinda, Ding, Zhejie, Doel, Peter, Duan, Yutong T., Ealet, Anne, Edelstein, Jerry, Eftekharzadeh, Sarah, Eisenstein, Daniel J., Elliott, Ann, Escoffier, Stéphanie, Evatt, Matthew, Fagrelius, Parker, Fan, Xiaohui, Fanning, Kevin, Farahi, Arya, Farihi, Jay, Favole, Ginevra, Feng, Yu, Fernandez, Enrique, Findlay, Joseph R., Finkbeiner, Douglas P., Fitzpatrick, Michael J., Flaugher, Brenna, Flender, Samuel, Font-Ribera, Andreu, Forero-Romero, Jaime E., Fosalba, Pablo, Frenk, Carlos S., Fumagalli, Michele, Gaensicke, Boris T., Gallo, Giuseppe, Garcia-Bellido, Juan, Gaztanaga, Enrique, Fusillo, Nicola Pietro Gentile, Gerard, Terry, Gershkovich, Irena, Giannantonio, Tommaso, Gillet, Denis, Gonzalez-de-Rivera, Guillermo, Gonzalez-Perez, Violeta, Gott, Shelby, Graur, Or, Gutierrez, Gaston, Guy, Julien, Habib, Salman, Heetderks, Henry, Heetderks, Ian, Heitmann, Katrin, Hellwing, Wojciech A., Herrera, David A., Ho, Shirley, Holland, Stephen, Honscheid, Klaus, Huff, Eric, Hutchinson, Timothy A., Huterer, Dragan, Hwang, Ho Seong, Laguna, Joseph Maria Illa, Ishikawa, Yuzo, Jacobs, Dianna, Jeffrey, Niall, Jelinsky, Patrick, Jennings, Elise, Jiang, Linhua, Jimenez, Jorge, Johnson, Jennifer, Joyce, Richard, Jullo, Eric, Juneau, Stéphanie, Kama, Sami, Karcher, Armin, Karkar, Sonia, Kehoe, Robert, Kennamer, Noble, Kent, Stephen, Kilbinger, Martin, Kim, Alex G., Kirkby, David, Kisner, Theodore, Kitanidis, Ellie, Kneib, Jean-Paul, Koposov, Sergey, Kovacs, Eve, Koyama, Kazuya, Kremin, Anthony, Kron, Richard, Kronig, Luzius, Kueter-Young, Andrea, Lacey, Cedric G., Lafever, Robin, Lahav, Ofer, Lambert, Andrew, Lampton, Michael, Landriau, Martin, Lang, Dustin, Lauer, Tod R., Goff, Jean-Marc Le, Guillou, Laurent Le, Van Suu, Auguste Le, Lee, Jae Hyeon, Lee, Su-Jeong, Leitner, Daniela, Lesser, Michael, Levi, Michael E., L'Huillier, Benjamin, Li, Baojiu, Liang, Ming, Lin, Huan, Linder, Eric, Loebman, Sarah R., Lukić, Zarija, Ma, Jun, MacCrann, Niall, Magneville, Christophe, Makarem, Laleh, Manera, Marc, Manser, Christopher J., Marshall, Robert, Martini, Paul, Massey, Richard, Matheson, Thomas, McCauley, Jeremy, McDonald, Patrick, McGreer, Ian D., Meisner, Aaron, Metcalfe, Nigel, Miller, Timothy N., Miquel, Ramon, Moustakas, John, Myers, Adam, Naik, Milind, Newman, Jeffrey A., Nichol, Robert C., Nicola, Andrina, da Costa, Luiz Nicolati, Nie, Jundan, Niz, Gustavo, Norberg, Peder, Nord, Brian, Norman, Dara, Nugent, Peter, O'Brien, Thomas, Oh, Minji, Olsen, Knut A. G., Padilla, Cristobal, Padmanabhan, Hamsa, Padmanabhan, Nikhil, Palanque-Delabrouille, Nathalie, Palmese, Antonella, Pappalardo, Daniel, Pâris, Isabelle, Park, Changbom, Patej, Anna, Peacock, John A., Peiris, Hiranya V., Peng, Xiyan, Percival, Will J., Perruchot, Sandrine, Pieri, Matthew M., Pogge, Richard, Pollack, Jennifer E., Poppett, Claire, Prada, Francisco, Prakash, Abhishek, Probst, Ronald G., Rabinowitz, David, Raichoor, Anand, Ree, Chang Hee, Refregier, Alexandre, Regal, Xavier, Reid, Beth, Reil, Kevin, Rezaie, Mehdi, Rockosi, Constance M., Roe, Natalie, Ronayette, Samuel, Roodman, Aaron, Ross, Ashley J., Ross, Nicholas P., Rossi, Graziano, Rozo, Eduardo, Ruhlmann-Kleider, Vanina, Rykoff, Eli S., Sabiu, Cristiano, Samushia, Lado, Sanchez, Eusebio, Sanchez, Javier, Schlegel, David J., Schneider, Michael, Schubnell, Michael, Secroun, Aurélia, Seljak, Uros, Seo, Hee-Jong, Serrano, Santiago, Shafieloo, Arman, Shan, Huanyuan, Sharples, Ray, Sholl, Michael J., Shourt, William V., Silber, Joseph H., Silva, David R., Sirk, Martin M., Slosar, Anze, Smith, Alex, Smoot, George F., Som, Debopam, Song, Yong-Seon, Sprayberry, David, Staten, Ryan, Stefanik, Andy, Tarle, Gregory, Tie, Suk Sien, Tinker, Jeremy L., Tojeiro, Rita, Valdes, Francisco, Valenzuela, Octavio, Valluri, Monica, Vargas-Magana, Mariana, Verde, Licia, Walker, Alistair R., Wang, Jiali, Wang, Yuting, Weaver, Benjamin A., Weaverdyck, Curtis, Wechsler, Risa H., Weinberg, David H., White, Martin, Yang, Qian, Yeche, Christophe, Zhang, Tianmeng, Zhao, Gong-Bo, Zheng, Yi, Zhou, Xu, Zhou, Zhimin, Zhu, Yaling, Zou, Hu, and Zu, Ying
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
DESI (Dark Energy Spectropic Instrument) is a Stage IV ground-based dark energy experiment that will study baryon acoustic oscillations and the growth of structure through redshift-space distortions with a wide-area galaxy and quasar redshift survey. The DESI instrument is a robotically-actuated, fiber-fed spectrograph capable of taking up to 5,000 simultaneous spectra over a wavelength range from 360 nm to 980 nm. The fibers feed ten three-arm spectrographs with resolution $R= \lambda/\Delta\lambda$ between 2000 and 5500, depending on wavelength. The DESI instrument will be used to conduct a five-year survey designed to cover 14,000 deg$^2$. This powerful instrument will be installed at prime focus on the 4-m Mayall telescope in Kitt Peak, Arizona, along with a new optical corrector, which will provide a three-degree diameter field of view. The DESI collaboration will also deliver a spectroscopic pipeline and data management system to reduce and archive all data for eventual public use.
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- 2016
222. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
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Nicolas, Aude, Kenna, Kevin P, Renton, Alan E, Ticozzi, Nicola, Faghri, Faraz, Chia, Ruth, Dominov, Janice A, Kenna, Brendan J, Nalls, Mike A, Keagle, Pamela, Rivera, Alberto M, van Rheenen, Wouter, Murphy, Natalie A, van Vugt, Joke JFA, Geiger, Joshua T, Van der Spek, Rick A, Pliner, Hannah A, Shankaracharya, Smith, Bradley N, Marangi, Giuseppe, Topp, Simon D, Abramzon, Yevgeniya, Gkazi, Athina Soragia, Eicher, John D, Kenna, Aoife, ITALSGEN Consortium, Mora, Gabriele, Calvo, Andrea, Mazzini, Letizia, Riva, Nilo, Mandrioli, Jessica, Caponnetto, Claudia, Battistini, Stefania, Volanti, Paolo, La Bella, Vincenzo, Conforti, Francesca L, Borghero, Giuseppe, Messina, Sonia, Simone, Isabella L, Trojsi, Francesca, Salvi, Fabrizio, Logullo, Francesco O, D'Alfonso, Sandra, Corrado, Lucia, Capasso, Margherita, Ferrucci, Luigi, Genomic Translation for ALS Care (GTAC) Consortium, Moreno, Cristiane de Araujo Martins, Kamalakaran, Sitharthan, Goldstein, David B, ALS Sequencing Consortium, Gitler, Aaron D, Harris, Tim, Myers, Richard M, NYGC ALS Consortium, Phatnani, Hemali, Musunuri, Rajeeva Lochan, Evani, Uday Shankar, Abhyankar, Avinash, Zody, Michael C, Answer ALS Foundation, Kaye, Julia, Finkbeiner, Steven, Wyman, Stacia K, LeNail, Alex, Lima, Leandro, Fraenkel, Ernest, Svendsen, Clive N, Thompson, Leslie M, Van Eyk, Jennifer E, Berry, James D, Miller, Timothy M, Kolb, Stephen J, Cudkowicz, Merit, Baxi, Emily, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Benatar, Michael, Taylor, J Paul, Rampersaud, Evadnie, Wu, Gang, Wuu, Joanne, SLAGEN Consortium, Lauria, Giuseppe, Verde, Federico, Fogh, Isabella, Tiloca, Cinzia, Comi, Giacomo P, Sorarù, Gianni, Cereda, Cristina, French ALS Consortium, Corcia, Philippe, Laaksovirta, Hannu, Myllykangas, Liisa, Jansson, Lilja, Valori, Miko, Ealing, John, Hamdalla, Hisham, Rollinson, Sara, Pickering-Brown, Stuart, and Orrell, Richard W
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ITALSGEN Consortium ,Genomic Translation for ALS Care (GTAC) Consortium ,ALS Sequencing Consortium ,NYGC ALS Consortium ,Answer ALS Foundation ,Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium ,SLAGEN Consortium ,French ALS Consortium ,Project MinE ALS Sequencing Consortium ,Humans ,Amyotrophic Lateral Sclerosis ,Cohort Studies ,Amino Acid Sequence ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Genome-Wide Association Study ,Young Adult ,Loss of Function Mutation ,Kinesins ,ALS ,GWAS ,KIF5A ,WES ,WGS ,axonal transport ,cargo ,Brain Disorders ,Genetics ,Human Genome ,Rare Diseases ,Neurosciences ,Neurodegenerative ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Psychology ,Cognitive Sciences ,Neurology & Neurosurgery - Abstract
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.
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- 2018
223. Philanthropic Institutions
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Miller, Timothy S., primary
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- 2022
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224. Parametric modeling of a solid state Ericsson cycle heat engine
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Miller, Timothy F.
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- 2021
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225. LCD Benchmark: Long Clinical Document Benchmark on Mortality Prediction
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Yoon, WonJin, primary, Chen, Shan, additional, Gao, Yanjun, additional, Dligach, Dmitriy, additional, Bitterman, Danielle S., additional, Afshar, Majid, additional, and Miller, Timothy, additional
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- 2024
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226. Leveraging A Medical Knowledge Graph into Large Language Models for Diagnosis Prediction (Preprint)
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Gao, Yanjun, primary, Li, Ruizhe, additional, Croxford, Emma, additional, Caskey, John R, additional, Patterson, Brian W, additional, Churpek, Matthew M., additional, Miller, Timothy, additional, Dligach, Dmitriy, additional, and Afshar, Majid, additional
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- 2024
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227. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
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Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Rothstein, Jeffrey D., and Svendsen, Clive N.
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- 2021
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228. Considerations for health care institutions training large language models on electronic health records (Preprint)
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Zhou, Weipeng, primary, Bitterman, Danielle, additional, Afshar, Majid, additional, and Miller, Timothy A., additional
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- 2024
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229. Cumulus: A federated EHR-based learning system powered by FHIR and AI
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McMurry, Andrew J., primary, Gottlieb, Daniel I., additional, Miller, Timothy A., additional, Jones, James R., additional, Atreja, Ashish, additional, Crago, Jennifer, additional, Desai, Pankaja M., additional, Dixon, Brian E., additional, Garber, Matthew, additional, Ignatov, Vladimir, additional, Kirchner, Lyndsey A., additional, Payne, Philip R. O., additional, Saldanha, Anil J., additional, Shankar, Prabhu R. V., additional, Solad, Yauheni V., additional, Sprouse, Elizabeth A., additional, Terry, Michael, additional, Wilcox, Adam B., additional, and Mandl, Kenneth D., additional
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- 2024
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230. Automated stratification of trauma injury severity across multiple body regions using multi-modal, multi-class machine learning models
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Gao, Jifan, primary, Chen, Guanhua, additional, O'Rourke, Ann P, additional, Caskey, John, additional, Carey, Kyle, additional, Oguss, Madeline, additional, Stey, Anne, additional, Dligach, Dmitriy, additional, Miller, Timothy, additional, Mayampurath, Anoop, additional, Churpek, Matthew M, additional, and Afshar, Majid, additional
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- 2024
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231. Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial
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Kiernan, Matthew, Mathers, Susan, Henderson, Robert, Needham, Merrilee, Schultz, David, Löscher, Wolfgang, Mitrovic, Nenad, Rath, Jakob, Damme, Philip Van, De Bleecker, Jan L., Delstanche, Stéphanie, Johnston, Wendy, Zinman, Lorne, O'Connell, Colleen, Matte, Genevieve, Dionne, Annie, Korngut, Lawrence, Turnbull, John, Laaksovirta, Hannu, Jokela, Manu, Tapiola, Tero, Soriani, Marie-Hélène, Couratier, Philippe, Camu, William, Corcia, Philippe, Ludolph, Albert, Großkreutz, Julian, Meyer, Thomas, Boentert, Matthias, Schrank, Berthold, Prudlo, Johannes, Untucht, Robert, Hardiman, Orla, Siciliano, Gabriele, Chio', Adriano, Mazzini, Letizia, Inghilleri, Maurizio, Caponnetto, Claudia, Mora, Gabriele, Mora Pardina, Jesús S, Farrero Munoz, Eva, Vázquez Costa, Juan F, Aguera Morales, Eduardo, Varona, Luis, Andersen, Peter, Ingre, Caroline, Johansson, Rune, Radunovic, Aleksandar, Young, Carolyn, Babu, Suma, Shaibani, Aziz, Staff, Nathan, Vu, Tuan, Rivner, Michael, Scelsa, Stephen, Sivakumar, Kumaraswamy, Waheed, Waqar, Heitzman, Daragh, Rana, Sandeep, Pattee, Gary, Ajroud-Driss, Senda, Bayat, Elham, Kasarskis, Edward, Lange, Dale J, Elliott, Michael, Harris, Brent, Felice, Kevin, Pulley, Michael T, Kwan, Justin, Brown, Martin, Ravits, John, Burford, Matthew, Karam, Chafic, Miller, Timothy, Andrews, Jinsy, Levine, Todd, Locatelli, Eduardo, Wymer, James, Bedlack, Richard, Fee, Dominic, Goyal, Namita, Oskarsson, Bjorn, McCluskey, Leo, Caress, James, Weiss, Michael, Quick, Adam, Bromberg, Mark, Lacomis, David, Goutman, Stephen, Rezania, Kourosh, Guliani, Gaurav, Goslin, Kimberly, Katz, Jonathan S, Cudkowicz, Merit, Genge, Angela, Maragakis, Nicholas, Petri, Susanne, van den Berg, Leonard, Aho, Valtteri V, Sarapohja, Toni, Kuoppamäki, Mikko, Garratt, Chris, and Al-Chalabi, Ammar
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- 2021
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232. A viral toolkit for recording transcription factor–DNA interactions in live mouse tissues
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Cammack, Alexander J., Moudgil, Arnav, Chen, Jiayang, Vasek, Michael J., Shabsovich, Mark, McCullough, Katherine, Yen, Allen, Lagunas, Tomas, Maloney, Susan E., He, June, Chen, Xuhua, Hooda, Misha, Wilkinson, Michael N., Miller, Timothy M., Mitra, Robi D., and Dougherty, Joseph D.
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- 2020
233. Clinical Natural Language Processing for Radiation Oncology: A Review and Practical Primer
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Bitterman, Danielle S., Miller, Timothy A., Mak, Raymond H., and Savova, Guergana K.
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- 2021
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234. Effect of native ligament versus graft reconstruction on sensitivity of clinical tests used to diagnose anterior cruciate ligament tears
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Vajapey, Sravya P. and Miller, Timothy L.
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- 2021
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235. Analysis of Co-spatial UV-optical STIS Spectra of Planetary Nebula NGC 3242
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Miller, Timothy R., Henry, Richard B. C., Balick, Bruce, Kwitter, Karen B., Dufour, Reginald J., Shaw, Richard A., and Corradi, Romano L. M.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
This project sought to consider two important aspects of the planetary nebula NGC 3242 using new long-slit HST/STIS spectra. First, we investigated whether this object is chemically homogeneous by dividing the slit into different regions spatially and calculating the abundances of each region. The major result is that the elements of He, C, O, and Ne are chemically homogeneous within uncertainties across the regions probed, implying that the stellar outflow was well-mixed. Second, we constrained the stellar properties using photoionization models computed by CLOUDY and tested the effects of three different density profiles on these parameters. The three profiles tested were a constant density profile, a Gaussian density profile, and a Gaussian with a power law density profile. The temperature and luminosity were not affected significantly by the choice of density structure. The values for the stellar temperature and luminosity from our best fit model are 89.7$^{+7.3}_{-4.7}$kK and log(L/Lsol)=3.36$^{+0.28}_{-0.22}$, respectively. Comparing to evolutionary models on an HR diagram, this corresponds to an initial and final mass of 0.95$^{+0.35}_{-0.09}$ Msol and 0.56$^{+0.01}_{-0.01}$ Msol, respectively., Comment: 41 pages, 5 figures, 12 tables, accepted for publication in ApJ
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- 2016
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236. The Primordial Inflation Polarization Explorer (PIPER)
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Gandilo, Natalie N., Ade, Peter A. R., Benford, Dominic, Bennett, Charles L., Chuss, David T., Dotson, Jessie L., Eimer, Joseph R., Fixsen, Dale J., Halpern, Mark, Hilton, Gene, Hinshaw, Gary F., Irwin, Kent, Jhabvala, Christine, Kimball, Mark, Kogut, Alan, Lowe, Luke, McMahon, Jeff J., Miller, Timothy M., Mirel, Paul, Moseley, S. Harvey, Pawlyk, Samuel, Rodriguez, Samelys, Sharp III, Elmer, Shirron, Peter, Staguhn, Johannes G., Sullivan, Dan F., Switzer, Eric R., Taraschi, Peter, Tucker, Carole E., and Wollack, Edward J.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Primordial Inflation Polarization ExploreR (PIPER) is a balloon-borne telescope designed to measure the polarization of the Cosmic Microwave Background on large angular scales. PIPER will map 85% of the sky at 200, 270, 350, and 600 GHz over a series of 8 conventional balloon flights from the northern and southern hemispheres. The first science flight will use two 32x40 arrays of backshort-under-grid transition edge sensors, multiplexed in the time domain, and maintained at 100 mK by a Continuous Adiabatic Demagnetization Refrigerator. Front-end cryogenic Variable-delay Polarization Modulators provide systematic control by rotating linear to circular polarization at 3 Hz. Twin telescopes allow PIPER to measure Stokes I, Q, U, and V simultaneously. The telescope is maintained at 1.5 K in an LHe bucket dewar. Cold optics and the lack of a warm window permit sensitivity at the sky-background limit. The ultimate science target is a limit on the tensor-to-scalar ratio of r ~ 0.007, from the reionization bump to l ~ 300. PIPER's first flight will be from the Northern hemisphere, and overlap with the CLASS survey at lower frequencies. We describe the current status of the PIPER instrument., Comment: 8 pages, 6 figures. To be published in Proceedings of SPIE Volume 9914. Presented at SPIE Astronomical Telescopes + Instrumentation 2016, conference 9914
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- 2016
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237. The Ultrafast Optical Response of the Amorphous and Crystalline States of the Phase Change Material Ge$_2$Sb$_2$Te$_5$
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Miller, Timothy A., Rudé, Miquel, Pruneri, Valerio, and Wall, Simon
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Condensed Matter - Materials Science - Abstract
We examine the ultrafast optical response of the crystalline and amorphous phases of the phase change material Ge$_2$Sb$_2$Te$_5$ below the phase transformation threshold. Simultaneous measurement of the transmissivity and reflectivity of thin film samples yields the time-dependent evolution of the dielectric function for both phases. We then identify how lattice motion and electronic excitation manifest in the dielectric response. The dielectric response of both phases is large but markedly different. At 800 nm, the changes in amorphous GST are well described by the Drude response of the generated photo-carriers, whereas the crystalline phase is better described by the depopulation of resonant bonds. We find that the generated coherent phonons have a greater influence in the amorphous phase than the crystalline phase. Furthermore, coherent phonons do not influence resonant bonding. For fluences up to 50% of the transformation threshold, the structure does not exhibit bond softening in either phase, enabling large changes of the optical properties without structural modification., Comment: 7 pages, 5 figures
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- 2016
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238. Imaging for Treated Aneurysms (Including Clipping, Coiling, Stents, Flow Diverters)
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Hostetter, Jason, Miller, Timothy R., and Gandhi, Dheeraj
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- 2021
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239. Patellar Tendinopathy in a 21-Year-Old Long Jumper
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Miller, Timothy L., primary, Baria, Michael, additional, Maffulli, Nicola, additional, Sherman, Seth L., additional, and Money, Adam, additional
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- 2021
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240. Operational Impacts of the Coronavirus Disease 2019 (COVID-19) Pandemic and Early Recovery Trends: University of Washington Anatomic Pathology Experience
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Miller, Timothy Isaac, Smith, Kelly D., Gonzalez-Cuyar, Luis Francisco, and Swanson, Paul E.
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Epidemics -- Social aspects -- Control ,Pathology -- Management ,Diagnosis, Laboratory -- Management ,Company business management ,Health ,University of Washington. School of Medicine -- Management - Abstract
Context.--The coronavirus disease 2019 pandemic, caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2, has resulted in worldwide disruption to the delivery of patient care. The Seattle, Washington metropolitan area was one of the first in the United States affected by the pandemic. As a result, the anatomic pathology services at the University of Washington experienced significant changes in operational volumes early in the pandemic. Objective.--To assess the impact of coronavirus disease 2019 and both state and institutional policies implemented to mitigate viral transmission (including institutional policies on nonurgent procedures) on anatomic pathology volumes. Design.--Accessioned specimens from January to June 2020 were evaluated as coronavirus disease 2019 and institutional policies changed. The data were considered in these contexts: subspecialty, billable Current Procedural Terminology codes, and intraoperative consultation. Comparable data were retrieved from 2019 as a historical control. Results.--There was a significant reduction in overall accessioned volume (up to 79%) from prepandemic levels during bans on nonurgent procedures when compared with 2020 pre-coronavirus disease 2019 volumes and historical controls. The gastrointestinal and dermatopathology services were most impacted, and breast and combined head and neck/pulmonary services were least impacted. Current Procedural Terminology code 88305, for smaller/biopsy specimens, had a 63% reduction during nonurgent procedure bans. After all bans on procedures were lifted, the overall volume plateaued at 89% of prepandemic levels. Conclusions.--A significant decrease in specimen volume was most strongly associated with bans on nonurgent procedures. Although all departmental areas had a decrease in volume, the extent of change varied across subspecialty and specimen types. Even with removal of all bans, service volume did not reach prepandemic levels. doi: 10.5858/arpa.2020-0639-SA, The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, has had a profound impact on routine operations within health care [...]
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- 2021
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241. Deep representation learning of patient data from Electronic Health Records (EHR): A systematic review
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Si, Yuqi, Du, Jingcheng, Li, Zhao, Jiang, Xiaoqian, Miller, Timothy, Wang, Fei, Jim Zheng, W., and Roberts, Kirk
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- 2021
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242. Association between perioperative fluid management and patient outcomes: a multicentre retrospective study
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Miller, Timothy E., Mythen, Monty, Shaw, Andrew D., Hwang, Seungyoung, Shenoy, Apeksha V., Bershad, Michael, and Hunley, Charles
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- 2021
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243. Pre-training phenotyping classifiers
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Dligach, Dmitriy, Afshar, Majid, and Miller, Timothy
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- 2021
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244. Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72‐associated amyotrophic lateral sclerosis
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Gendron, Tania F, Daughrity, Lillian M, Heckman, Michael G, Diehl, Nancy N, Wuu, Joanne, Miller, Timothy M, Pastor, Pau, Trojanowski, John Q, Grossman, Murray, Berry, James D, Hu, William T, Ratti, Antonia, Benatar, Michael, Silani, Vincenzo, Glass, Jonathan D, Floeter, Mary Kay, Jeromin, Andreas, Boylan, Kevin B, Petrucelli, Leonard, and Group, the C9ORF72 Neurofilament Study
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,ALS ,Brain Disorders ,Rare Diseases ,Neurodegenerative ,Clinical Research ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Neurological ,Good Health and Well Being ,Adult ,Aged ,Aged ,80 and over ,Amyotrophic Lateral Sclerosis ,Biomarkers ,C9orf72 Protein ,Case-Control Studies ,Disease Progression ,Female ,Humans ,Male ,Middle Aged ,Neurofilament Proteins ,Phosphorylation ,Proteins ,Survival Analysis ,Young Adult ,C9ORF72 Neurofilament Study Group ,Neurology & Neurosurgery ,Clinical sciences - Abstract
As potential treatments for C9ORF72-associated amyotrophic lateral sclerosis (c9ALS) approach clinical trials, the identification of prognostic biomarkers for c9ALS becomes a priority. We show that levels of phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid (CSF) predict disease status and survival in c9ALS patients, and are largely stable over time. Moreover, c9ALS patients exhibit higher pNFH levels, more rapid disease progression, and shorter survival after disease onset than ALS patients without C9ORF72 expansions. These data support the use of CSF pNFH as a prognostic biomarker for clinical trials, which will increase the likelihood of successfully developing a treatment for c9ALS. Ann Neurol 2017;82:139-146.
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- 2017
245. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis
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Gendron, Tania F, Chew, Jeannie, Stankowski, Jeannette N, Hayes, Lindsey R, Zhang, Yong-Jie, Prudencio, Mercedes, Carlomagno, Yari, Daughrity, Lillian M, Jansen-West, Karen, Perkerson, Emilie A, O'Raw, Aliesha, Cook, Casey, Pregent, Luc, Belzil, Veronique, van Blitterswijk, Marka, Tabassian, Lilia J, Lee, Chris W, Yue, Mei, Tong, Jimei, Song, Yuping, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Dickson, Dennis W, Rademakers, Rosa, Fryer, John D, Rush, Beth K, Pedraza, Otto, Caputo, Ana M, Desaro, Pamela, Palmucci, Carla, Robertson, Amelia, Heckman, Michael G, Diehl, Nancy N, Wiggs, Edythe, Tierney, Michael, Braun, Laura, Farren, Jennifer, Lacomis, David, Ladha, Shafeeq, Fournier, Christina N, McCluskey, Leo F, Elman, Lauren B, Toledo, Jon B, McBride, Jennifer D, Tiloca, Cinzia, Morelli, Claudia, Poletti, Barbara, Solca, Federica, Prelle, Alessandro, Wuu, Joanne, Jockel-Balsarotti, Jennifer, Rigo, Frank, Ambrose, Christine, Datta, Abhishek, Yang, Weixing, Raitcheva, Denitza, Antognetti, Giovanna, McCampbell, Alexander, Van Swieten, John C, Miller, Bruce L, Boxer, Adam L, Brown, Robert H, Bowser, Robert, Miller, Timothy M, Trojanowski, John Q, Grossman, Murray, Berry, James D, Hu, William T, Ratti, Antonia, Traynor, Bryan J, Disney, Matthew D, Benatar, Michael, Silani, Vincenzo, Glass, Jonathan D, Floeter, Mary Kay, Rothstein, Jeffrey D, Boylan, Kevin B, and Petrucelli, Leonard
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Clinical Research ,Neurodegenerative ,Brain Disorders ,Acquired Cognitive Impairment ,Dementia ,Neurosciences ,ALS ,Rare Diseases ,Clinical Trials and Supportive Activities ,Genetics ,Neurological ,Adult ,Aged ,Amyotrophic Lateral Sclerosis ,Animals ,Biomarkers ,Brain ,C9orf72 Protein ,Cell Line ,Dinucleotide Repeats ,Humans ,Induced Pluripotent Stem Cells ,Leukocytes ,Mononuclear ,Longitudinal Studies ,Mice ,Middle Aged ,Neurons ,Oligonucleotides ,Antisense ,Prognosis ,RNA ,Biological Sciences ,Medical and Health Sciences - Abstract
There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a G4C2 repeat expansion in the C9ORF72 gene as the most common genetic cause of ALS has opened up new avenues for therapeutic intervention for this form of ALS. G4C2 repeat expansion RNAs and proteins of repeating dipeptides synthesized from these transcripts are believed to play a key role in C9ORF72-associated ALS (c9ALS). Therapeutics that target G4C2 RNA, such as antisense oligonucleotides (ASOs) and small molecules, are thus being actively investigated. A limitation in moving such treatments from bench to bedside is a lack of pharmacodynamic markers for use in clinical trials. We explored whether poly(GP) proteins translated from G4C2 RNA could serve such a purpose. Poly(GP) proteins were detected in cerebrospinal fluid (CSF) and in peripheral blood mononuclear cells from c9ALS patients and, notably, from asymptomatic C9ORF72 mutation carriers. Moreover, CSF poly(GP) proteins remained relatively constant over time, boding well for their use in gauging biochemical responses to potential treatments. Treating c9ALS patient cells or a mouse model of c9ALS with ASOs that target G4C2 RNA resulted in decreased intracellular and extracellular poly(GP) proteins. This decrease paralleled reductions in G4C2 RNA and downstream G4C2 RNA-mediated events. These findings indicate that tracking poly(GP) proteins in CSF could provide a means to assess target engagement of G4C2 RNA-based therapies in symptomatic C9ORF72 repeat expansion carriers and presymptomatic individuals who are expected to benefit from early therapeutic intervention.
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- 2017
246. Defining SOD1 ALS natural history to guide therapeutic clinical trial design
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Bali, Taha, Self, Wade, Liu, Jingxia, Siddique, Teepu, Wang, Leo H, Bird, Thomas D, Ratti, Elena, Atassi, Nazem, Boylan, Kevin B, Glass, Jonathan D, Maragakis, Nicholas J, Caress, James B, McCluskey, Leo F, Appel, Stanley H, Wymer, James P, Gibson, Summer, Zinman, Lorne, Mozaffar, Tahseen, Callaghan, Brian, McVey, April L, Jockel-Balsarotti, Jennifer, Allred, Peggy, Fisher, Elena R, Lopate, Glenn, Pestronk, Alan, Cudkowicz, Merit E, and Miller, Timothy M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Neurosciences ,ALS ,Rare Diseases ,Clinical Research ,Neurodegenerative ,Clinical Trials and Supportive Activities ,Adult ,Age of Onset ,Amyotrophic Lateral Sclerosis ,Clinical Trials as Topic ,Disease Progression ,Humans ,Middle Aged ,Mutation ,Research Design ,Retrospective Studies ,Superoxide Dismutase ,Vital Capacity ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
ImportanceUnderstanding the natural history of familial amyotrophic lateral sclerosis (ALS) caused by SOD1 mutations (ALSSOD1) will provide key information for optimising clinical trials in this patient population.ObjectiveTo establish an updated natural history of ALSSOD1.Design, setting and participantsRetrospective cohort study from 15 medical centres in North America evaluated records from 175 patients with ALS with genetically confirmed SOD1 mutations, cared for after the year 2000.Main outcomes and measuresAge of onset, survival, ALS Functional Rating Scale (ALS-FRS) scores and respiratory function were analysed. Patients with the A4V (Ala-Val) SOD1 mutation (SOD1A4V), the largest mutation population in North America with an aggressive disease progression, were distinguished from other SOD1 mutation patients (SOD1non-A4V) for analysis.ResultsMean age of disease onset was 49.7±12.3 years (mean±SD) for all SOD1 patients, with no statistical significance between SOD1A4V and SOD1non-A4V (p=0.72, Kruskal-Wallis). Total SOD1 patient median survival was 2.7 years. Mean disease duration for all SOD1 was 4.6±6.0 and 1.4±0.7 years for SOD1A4V. SOD1A4V survival probability (median survival 1.2 years) was significantly decreased compared with SOD1non-A4V (median survival 6.8 years; p
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- 2017
247. Resonant optical control of the structural distortions that drive ultrafast demagnetization in Cr$_2$O$_3$
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Sala, Vera G., Conte, Stefano Dal, Miller, Timothy A., Viola, Daniele, Luppi, Elenora, Véniard, Valérie, Cerullo, Giulio, and Wall, Simon
- Subjects
Condensed Matter - Materials Science ,Physics - Optics - Abstract
We study how the color and polarization of ultrashort pulses of visible light can be used to control the demagnetization processes of the antiferromagnetic insulator Cr$_2$O$_3$. We utilize time-resolved second harmonic generation (SHG) to probe how changes in the magnetic and structural state evolve in time. We show that, varying the pump photon-energy to excite either localized transitions within the Cr or charge transfer states, leads to markedly different dynamics. Through a full polarization analysis of the SHG signal, symmetry considerations and density functional theory calculations, we show that, in the non-equilibrium state, SHG is sensitive to {\em both} lattice displacements and changes to the magnetic order, which allows us to conclude that different excited states couple to phonon modes of different symmetries. Furthermore, the spin-scattering rate depends on the induced distortion, enabling us to control the timescale for the demagnetization process. Our results suggest that selective photoexcitation of antiferromagnetic insulators allows fast and efficient manipulation of their magnetic state., Comment: 7 pages, 5 figures
- Published
- 2015
- Full Text
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248. Ultrafast broadband tuning of resonant optical nanostructures using phase change materials
- Author
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Rudé, Miquel, Mkhitaryan, Vahagn, Cetin, Arif E., Miller, Timothy A., Carrilero, Albert, Wall, Simon, de Abajo, F. Javier García, Altug, Hatice, and Pruneri, Valerio
- Subjects
Physics - Optics - Abstract
The functionalities of a wide range of optical and opto-electronic devices are based on resonance effects and active tuning of the amplitude and wavelength response is often essential. Plasmonic nanostructures are an efficient way to create optical resonances, a prominent example is the extraordinary optical transmission (EOT) through arrays of nanoholes patterned in a metallic film. Tuning of resonances by heating, applying electrical or optical signals has proven to be more elusive, due to the lack of materials that can induce modulation over a broad spectral range and/or at high speeds. Here we show that nanopatterned metals combined with phase change materials (PCMs) can overcome this limitation due to the large change in optical constants which can be induced thermally or on an ultrafast timescale. We demonstrate resonance wavelength shifts as large as 385 nm - an order of magnitude higher than previously reported - by combining properly designed Au EOT nanostructures with Ge2Sb2Te5 (GST). Moreover, we show, through pump probe measurements, repeatable and reversible, large amplitude modulations in the resonances, especially at telecommunication wavelengths, over ps time scales and at powers far below those needed to produce a permanent phase transition. Our findings open a pathway to the design of hybrid metal PCM nanostructures with ultrafast and widely tuneable resonance responses, which hold potential impact on active nanophotonic devices such as tuneable optical filters, smart windows, biosensors and reconfigurable memories.
- Published
- 2015
- Full Text
- View/download PDF
249. THz Field Control of In-Plane Orbital Order in La0.5Sr1.5MnO4
- Author
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Miller, Timothy A., Chhajlany, Ravindra W., Tagliacozzo, Luca, Green, Bertram, Kovalev, Sergey, Prabhakaran, Dharmalingam, Lewenstein, Maciej, Gensch, Michael, and Wall, Simon
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
In-plane anisotropic ground states are ubiquitous in correlated solids such as pnictides, cuprates and manganites. They can arise from doping Mott insulators and compete with phases such as superconductivity, however their origins are debated. Strong coupling between lattice, charge, orbital and spin degrees of freedom results in simultaneous ordering of multiple parameters, masking the mechanism that drives the transition. We demonstrate that the anisotropic orbital domains in a manganite can be oriented by the polarization of a pulsed THz light field. Through the application of the Hubbard model, we show that domain control can be achieved either through field assisted hopping of charges or a field-induced modification of bond angles. Both routes enhance the local Coulomb repulsions which drive domain reorientation and the dominant mechanism is dictated by the equilibrium Mn-O-Mn bond angle. Our results highlight the key role played by the Coulomb interaction in driving orbital order in manganites and demonstrate how THz can be utilized in new ways to understand and manipulate anisotropic phases in a broad range of correlated materials., Comment: 19 pages including supplementary information, 5 figures
- Published
- 2015
- Full Text
- View/download PDF
250. Time-Domain Separation of Optical Properties From Structural Transitions in Resonantly Bonded Materials
- Author
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Waldecker, Lutz, Miller, Timothy A., Rude, Miquel, Bertoni, Roman, Osmond, Johann, Pruneri, Valerio, Simpson, Robert, Ernstorfer, Ralph, and Wall, Simon
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Other Condensed Matter - Abstract
The extreme electro-optical contrast between crystalline and amorphous states in phase change materials is routinely exploited in optical data storage and future applications include universal memories, flexible displays, reconfigurable optical circuits, and logic devices. Optical contrast is believed to arise due to a change in crystallinity. Here we show that the connection between optical properties and structure can be broken. Using a unique combination of single-shot femtosecond electron diffraction and optical spectroscopy, we simultaneously follow the lattice dynamics and dielectric function in the phase change material Ge2Sb2Te5 during an irreversible state transformation. The dielectric function changes by 30% within 100 femtoseconds due to a rapid depletion of electrons from resonantly-bonded states. This occurs without perturbing the crystallinity of the lattice, which heats with a 2 ps time constant. The optical changes are an order-of-magnitude larger than those achievable with silicon and present new routes to manipulate light on an ultrafast timescale without structural changes.
- Published
- 2014
- Full Text
- View/download PDF
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