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1,152 results on '"Moore Lynne"'

203. Effect of psychosocial work factors on the risk of depression: a protocol of a systematic review and meta-analysis of prospective studies

Author

Duchaine, Caroline S, primary, Aubé, Karine, additional, Gilbert-Ouimet, Mahee, additional, Bruno Pena Gralle, Ana Paula, additional, Vezina, Michel, additional, Ndjaboue, Ruth, additional, Massamba, Victoria K, additional, Trudel, Xavier, additional, Lesage, Alain, additional, Moore, Lynne, additional, Laurin, Danielle, additional, and Brisson, Chantal, additional

Published
2019
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204. Low-value clinical practices in adult traumatic brain injury: an umbrella review protocol

Author

Tardif, Pier-Alexandre, primary, Moore, Lynne, additional, Lauzier, François, additional, Farhat, Imen, additional, Archambault, Patrick, additional, Lamontagne, Francois, additional, Chassé, Michael, additional, Stelfox, Henry Thomas, additional, Gabbe, Belinda J, additional, Lecky, Fiona, additional, Kortbeek, John, additional, Lessard-Bonaventure, Paule, additional, Truchon, Catherine, additional, and Turgeon, Alexis F, additional

Published
2019
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205. Resource use for older people hospitalised due to injury in a Canadian integrated trauma system: a retrospective multicenter cohort study

Author

Farhat, Imen, primary, Moore, Lynne, additional, Porgo, Teegwendé Valérie, additional, Patton, Marie-Pier, additional, Tardif, Pier-Alexandre, additional, Truchon, Catherine, additional, Berthelot, Simon, additional, Stelfox, Henry T, additional, Gabbe, Belinda J, additional, Lauzier, François, additional, Turgeon, Alexis F, additional, and Clément, Julien, additional

Published
2019
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207. Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury

Author

Turgeon, Alexis F., primary, Dorrance, Kristin, additional, Archambault, Patrick, additional, Lauzier, François, additional, Lamontagne, François, additional, Zarychanski, Ryan, additional, Fowler, Robert, additional, Moore, Lynne, additional, Lacroix, Jacques, additional, English, Shane, additional, Boutin, Amélie, additional, Muscedere, John, additional, Burns, Karen E.A., additional, Griesdale, Donald, additional, McIntyre, Lauralyn A., additional, Scales, Damon, additional, Bernard, Francis, additional, Yamada, Janet, additional, and Squires, Janet E., additional

Published
2019
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208. Prognostic Value of Glial Fibrillary Acidic Protein in Patients With Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Author

Shemilt, Michèle, primary, Boutin, Amélie, additional, Lauzier, François, additional, Zarychanski, Ryan, additional, Moore, Lynne, additional, McIntyre, Lauralyn A., additional, Nadeau, Linda, additional, Fergusson, Dean A., additional, Mercier, Eric, additional, Archambault, Patrick, additional, Lamontagne, François, additional, Perron, Caroline, additional, Léger, Caroline, additional, and Turgeon, Alexis F., additional

Published
2019
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209. Patient-level resource use for injury admissions in Canada: A multicentre retrospective cohort study

Author

Porgo, Teegwendé V., primary, Moore, Lynne, additional, Truchon, Catherine, additional, Berthelot, Simon, additional, Stelfox, Henry T., additional, Cameron, Peter A., additional, Gabbe, Belinda J., additional, Hoch, Jeffrey S., additional, Evans, David C., additional, Lauzier, François, additional, Bernard, Francis, additional, Turgeon, Alexis F., additional, and Clément, Julien, additional

Published
2019
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210. Low-value clinical practices in injury care: A scoping review and expert consultation survey

Author

Moore, Lynne, primary, Lauzier, François, additional, Tardif, Pier-Alexandre, additional, Boukar, Khadidja Malloum, additional, Farhat, Imen, additional, Archambault, Patrick, additional, Mercier, Éric, additional, Lamontagne, François, additional, Chassé, Michael, additional, Stelfox, Henry T., additional, Berthelot, Simon, additional, Gabbe, Belinda, additional, Lecky, Fiona, additional, Yanchar, Natalie, additional, Champion, Howard, additional, Kortbeek, John, additional, Cameron, Peter, additional, Bonaventure, Paule Lessard, additional, Paquet, Jérôme, additional, Truchon, Catherine, additional, and Turgeon, Alexis F., additional

Published
2019
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212. Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

Author

Marchetto, Maria C, primary, Hrvoj-Mihic, Branka, additional, Kerman, Bilal E, additional, Yu, Diana X, additional, Vadodaria, Krishna C, additional, Linker, Sara B, additional, Narvaiza, Iñigo, additional, Santos, Renata, additional, Denli, Ahmet M, additional, Mendes, Ana PD, additional, Oefner, Ruth, additional, Cook, Jonathan, additional, McHenry, Lauren, additional, Grasmick, Jaeson M, additional, Heard, Kelly, additional, Fredlender, Callie, additional, Randolph-Moore, Lynne, additional, Kshirsagar, Rijul, additional, Xenitopoulos, Rea, additional, Chou, Grace, additional, Hah, Nasun, additional, Muotri, Alysson R, additional, Padmanabhan, Krishnan, additional, Semendeferi, Katerina, additional, and Gage, Fred H, additional

Published
2019
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215. Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol.

Author

Laflamme, Mathieu, Haghbayan, Hourmazd, Lalu, Manoj M., Zarychanski, Ryan, Lauzier, François, Boutin, Amélie, Macleod, Malcolm R., Fergusson, Dean A., Moore, Lynne, Costerousse, Olivier, Lacroix, Jacques, Wellington, Cheryl, Hutchison, Jamie, and Turgeon, Alexis F.

Subjects
RED blood cell transfusion, INTRACRANIAL pressure, BRAIN injuries, MEDICAL research, ANIMAL models in research, BLOOD transfusion
Abstract

Background: Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models. Methods: We will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE, and Web of Science databases for eligible studies from inception onwards. Two independent reviewers will perform study selection and data extraction. We will report our results in a descriptive synthesis focusing on characteristics of included studies, reported outcomes, risk of bias, and construct validity. Our primary outcome is the neurological function (neurobehavioral performance) and our secondary outcomes include mortality, infarct size, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and brain tissue oxygen tension. If appropriate, we will also perform a quantitative synthesis and pool results using random-effect models. Heterogeneity will be expressed with I2 statistics. Subgroup analyses are planned according to animal model characteristics, co-interventions, and risks of bias. Discussion: Our study is aligned with the efforts to better understand the level of evidence on the impact of red blood cell transfusion strategies from preclinical studies in animal models of acute brain injury and the potential translation of information from the preclinical to the clinical research field. Systematic review registration: PROSPERO CRD42018086662. [ABSTRACT FROM AUTHOR]

Published
2021
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216. Development and Validation of a Hospital Indicator of Activity-Based Costs for Injury Admissions.

Author

Porgo, Teegwendé V., Moore, Lynne, Assy, Coralie, Neveu, Xavier, Gonthier, Catherine, Berthelot, Simon, Gabbe, Belinda J., Cameron, Peter A., Bernard, Francis, and Turgeon, Alexis F.

Subjects
*TRAUMA centers, *ACTIVITY-based costing, *BRAIN injuries, *TRAUMA registries, *FINANCIAL statements, *WOUNDS & injuries, *HOSPITAL admission & discharge, *RESEARCH, *RESEARCH methodology, *RETROSPECTIVE studies, *HEALTH status indicators, *ACQUISITION of data, *MEDICAL cooperation, *EVALUATION research, *RISK assessment, *SEVERITY of illness index, *BENCHMARKING (Management), *COMPARATIVE studies, *TRAUMA severity indices, *RESOURCE allocation, *ALGORITHMS, *STANDARDS
Abstract

Objectives: To develop a hospital indicator of resource use for injury admissions.Methods: We focused on resource use for acute injury care and therefore adopted a hospital perspective. We included patients ≥16 years old with an Injury Severity Score >9 admitted to any of the 57 trauma centers of an inclusive Canadian trauma system from 2014 to 2018. We extracted data from the trauma registry and hospital financial reports and estimated resource use with activity-based costing. We developed risk-adjustment models by trauma center designation level (I/II and III/IV) for the whole sample, traumatic brain injuries, thoraco-abdominal injuries, orthopedic injuries, and patients ≥65 years old. Candidate variables were selected using bootstrap resampling. We performed benchmarking by comparing the adjusted mean cost in each center, obtained using shrinkage estimates, to the provincial mean.Results: We included 38 713 patients. The models explained between 12% and 36% (optimism-corrected r2) of the variation in resource use. In the whole sample and in all subgroups, we identified centers with higher- or lower-than-expected resource use across level I/II and III/IV centers.Conclusions: We propose an algorithm to produce the indicator using data routinely collected in trauma registries to prompt targeted exploration of potential areas for improvement in resource use for injury admissions. The r2 of our models suggest that between 64% and 88% of the variation in resource use for injury care is dictated by factors other than patient baseline risk. [ABSTRACT FROM AUTHOR]

Published
2021
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217. Depression in the first year after traumatic brain injury

Author

Ouellet, Marie-Christine, Beaulieu-Bonneau, Simon, Sirois, Marie-Josée, Savard, Josée, Turgeon-Fournier, Alexis, Moore, Lynne, Swaine, Bonnie, Roy, Joanne, Giguère, Myriam, Laviolette, Valérie, Ouellet, Marie-Christine, Beaulieu-Bonneau, Simon, Sirois, Marie-Josée, Savard, Josée, Turgeon-Fournier, Alexis, Moore, Lynne, Swaine, Bonnie, Roy, Joanne, Giguère, Myriam, and Laviolette, Valérie

Abstract

The aims of this study were to document the frequency of major and minor depressive episodes in the first year after traumatic brain injury (TBI), taking into account TBI severity and pre-morbid history of major depression, and to describe trajectories of depressive episodes. Participants were 227 adults who were hospitalized post-TBI (76% male; mean age = 41 years; 50% mild, 33% moderate, and 17% severe TBI). Major and minor depressive episodes were assessed with the Mini International Neuropsychiatric Interview at three time points (4, 8, and 12 months after TBI). Overall, 29% of participants had a major depressive episode in at least one of the three assessments, with fairly stable rates across assessments. Participants with mild TBI were more likely than those with moderate/severe TBI to be diagnosed with major depression, as were individuals with a positive pre-morbid history of depression compared to those without such history. In addition, 13% of participants had a minor depressive episode in at least one of the three assessments. Rates of minor depression significantly decreased from 4 to 8–12 months post-injury. Results also revealed a wide variety of trajectories of depressive episodes across assessments. Of note, 52% of major depression cases still fulfilled diagnostic criteria 4 months later, whereas 38% of minor depression cases deteriorated to major depression at the following assessment. These findings suggest that depression is highly prevalent after TBI, and monitoring of patients with subthreshold depressive symptoms is warranted in order to prevent the development of full-blown major depressive episodes.

Published
2018

218. High dose versus low dose standardized cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection in healthy women: a double-blind randomized controlled trial.

Author

Babar, Asma, Moore, Lynne, Leblanc, Vicky, Dudonné, Stéphanie, Desjardins, Yves, Lemieux, Simone, Bochard, Valérie, Guyonnet, Denis, and Dodin, Sylvie

Subjects
URINARY tract infections, RANDOMIZED controlled trials, CRANBERRIES, DISEASE relapse, PROANTHOCYANIDINS
Abstract

Purpose: Our objective was to assess the efficacy of a high dose cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection.Material and Methods: We recruited 145 healthy, adult women with a history of recurrent urinary tract infection, defined as ≥ 2 in the past 6 months or ≥ 3 in the past 12 months in this randomized, controlled, double-blind clinical trial. Participants were randomized to receive a high dose of standardized, commercially available cranberry proanthocyanidins (2 × 18.5 mg daily, n = 72) or a control low dose (2 × 1 mg daily, n = 73) for a 24-week period. During follow-up, symptomatic women provided urine samples for detection of pyuria and/or bacteriuria and received an appropriate antibiotic prescription. The primary outcome for the trial was the mean number of new symptomatic urinary tract infections during a 24-week intervention period. Secondary outcomes included symptomatic urinary tract infection with pyuria or bacteriuria.Results: In response to the intervention, a non-significant 24% decrease in the number of symptomatic urinary tract infections was observed between groups (Incidence rate ratio 0.76, 95%CI 0.51-1.11). Post-hoc analyses indicated that among 97 women who experienced less than 5 infections in the year preceding enrolment, the high dose was associated with a significant decrease in the number of symptomatic urinary tract infections reported compared to the low dose (age-adjusted incidence rate ratio 0.57, 95%CI 0.33-0.99). No major side effects were reported.Conclusion: High dose twice daily proanthocyanidin extract was not associated with a reduction in the number of symptomatic urinary tract infections when compared to a low dose proanthocyanidin extract. Our post-hoc results reveal that this high dose of proanthocyanidins may have a preventive impact on symptomatic urinary tract infection recurrence in women who experienced less than 5 infections per year.Trial Registration: Clinicaltrials.gov, identifier NCT02572895. [ABSTRACT FROM AUTHOR]

Published
2021
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219. Persistent Postconcussion Symptoms: An Expert Consensus-Based Definition Using the Delphi Method.

Author

Lagacé-Legendre, Corinne, Boucher, Valérie, Robert, Sébastien, Tardif, Pier-Alexandre, Ouellet, Marie-Christine, de Guise, Elaine, Boulard, Geneviève, Frémont, Pierre, Émond, Marcel, Moore, Lynne, and Le Sage, Natalie

Abstract

Objective: To provide an expert consensus definition of persistent postconcussion symptoms following a mild traumatic brain injury (mTBI). Participants: Canadian healthcare professionals caring for patients with mTBI. Design: Online Delphi process. Main Measures: A first Delphi round documented important dimensions or criteria to consider when defining persistent symptoms. Expert opinions were then resubmitted in 4 subsequent Delphi rounds and their relevance was rated using a 9-point Likert scale. An item with a median rating of 7 or more and a sufficient level of agreement were considered consensual. Results: After 5 rounds, consensus was reached on a set of criteria that can be summarized as follows: presence of any symptom that cannot be attributed to a preexisting condition and that appeared within hours of an mTBI, that is still present every day 3 months after the trauma, and that has an impact on at least one sphere of a person's life. Conclusion: This Delphi consensus proposes a set of criteria that support a more uniform definition of persistent symptoms in mild TBI among clinicians and researchers. This definition may help clinicians better identify persistent postconcussion symptoms and improve patient management. [ABSTRACT FROM AUTHOR]

Published
2021
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220. Addressing Competing Risks When Assessing the Impact of Health Services Interventions on Hospital Length of Stay.

Author

Batomen, Brice, Moore, Lynne, Strumpf, Erin, and Nandi, Arijit

Subjects
HOSPITALS, LENGTH of stay in hospitals, RESEARCH, RESEARCH methodology, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, DISCHARGE planning
Abstract

Background: Although hospital length of stay is generally modeled continuously, it is increasingly recommended that length of stay should be considered a time-to-event outcome (i.e., time to discharge). Additionally, in-hospital mortality is a competing risk that makes it impossible for a patient to be discharged alive. We estimated the effect of trauma center accreditation on risk of being discharged alive while considering in-hospital mortality as a competing risk. We also compared these results with those from the "naive" approach, with length of stay modeled continuously.Methods: Data include admissions to a level I trauma center in Quebec, Canada, between 2008 and 2017. We computed standardized risk of being discharged alive at specific days by combining inverse probability weighting and the Aalen-Johansen estimator of the cumulative incidence function. We estimated effect of accreditation using pre-post, interrupted time series (ITS) analyses, and the "naive" approach.Results: Among 5,300 admissions, 12% died, and 83% were discharged alive within 60 days. Following accreditation, we observed increases in risk of discharge between the 7th day (4.5% [95% CI = 2.3, 6.6]) and 30th day since admission 3.8% (95% CI = 1.5, 6.2). We also observed a stable decrease in hospital mortality, -1.9% (95% CI = -3.6, -0.11) at the 14th day. Although pre-post and ITS produced similar results, we observed contradictory associations with the naive approach.Conclusions: Treating length of stay as time to discharge allows for estimation of risk of being discharged alive at specific days after admission while accounting for competing risk of death. [ABSTRACT FROM AUTHOR]

Published
2021
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221. Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis.

Author

Bedrosian, Tracy A, Houtman, Judith, Eguiguren, Juan Sebastian, Ghassemzadeh, Saeed, Rund, Nicole, Novaresi, Nicole M, Hu, Lauren, Parylak, Sarah L., Denli, Ahmet M, Randolph‐Moore, Lynne, Namba, Takashi, Gage, Fred H, and Toda, Tomohisa

Subjects
DEVELOPMENTAL neurobiology, MOOD (Psychology), CELLULAR aging, HIPPOCAMPUS (Brain), NUCLEAR membranes
Abstract

Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age‐related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age‐related anxiety‐like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation. SYNOPSIS: Mutations in the nuclear envelope protein lamin B1 are linked to cellular aging and senescence. Here, lamin B1 ablation in adult neural stem/progenitor cells (ANSPCs) in mice is shown to disrupt neurogenesis, leading to aging‐related behavioral changes. Lamin B1 is highly expressed in ANSPCs, but selectively declines with age.Conditional knockout of lamin B1 in ANSPCs leads to premature differentiation and reduction of adult hippocampal neurogenesis.Lamin B1 knockout leads to age‐related anxiety‐like behaviours in mice.Overexpression of lamin B1 suppresses ANSPC differentiation. [ABSTRACT FROM AUTHOR]

Published
2021
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222. Effectiveness of trauma centre verification: a systematic review and meta-analysis.

Author

Batomen, Brice, Moore, Lynne, Carabali, Mabel, Tardif, Pier-Alexandre, Champion, Howard, and Nandi, Arijit

Subjects
*HOSPITAL mortality, *ROBUST control, *GREY literature, *CONFIDENCE intervals, *MEDICAL care, *TRAUMA centers, *RESEARCH, *META-analysis, *JOB qualifications, *RESEARCH methodology, *SYSTEMATIC reviews, *MEDICAL cooperation, *EVALUATION research, *TREATMENT effectiveness, *COMPARATIVE studies
Abstract

Background: There is a growing trend toward verification of trauma centres, but its impact remains unclear. This systematic review aimed to synthesize available evidence on the effectiveness of trauma centre verification.Methods: We conducted a systematic search of the CINAHL, Embase, HealthStar, MEDLINE and ProQuest databases, as well as the websites of key injury organizations for grey literature, from inception to June 2019, without language restrictions. Our population consisted of injured patients treated at trauma centres. The intervention was trauma centre verification. Comparison groups comprised nonverified trauma centres, or the same centre before it was first verified or re-verified. The primary outcome was in-hospital mortality; secondary outcomes included adverse events, resource use and processes of care. We computed pooled summary estimates using random-effects meta-analysis.Results: Of 5125 citations identified, 29, all conducted in the United States, satisfied our inclusion criteria. Mortality was the most frequently investigated outcome (n = 20), followed by processes of care (n = 12), resource use (n = 12) and adverse events (n = 7). The risk of bias was serious to critical in 22 studies. We observed an imprecise association between verification and decreased mortality (relative risk 0.74, 95% confidence interval 0.52 to 1.06) in severely injured patients.Conclusion: Our review showed mixed and inconsistent associations between verification and processes of care or patient outcomes. The validity of the published literature is limited by the lack of robust controls, as well as any evidence from outside the US, which precludes extrapolation to other health care jurisdictions. Quasiexperimental studies are needed to assess the impact of trauma centre verification.Systematic reviews registration: PROSPERO no. CRD42018107083. [ABSTRACT FROM AUTHOR]

Published
2021
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223. Stem Cell Reports Resource Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells

Author

Santos, Renata, Vadodaria, Krishna, Jaeger, Baptiste, Mei, Arianna, Lefcochilos-Fogelquist, Sabrina, Mendes, Ana P.D., Erikson, Galina, Shokhirev, Maxim, Randolph-Moore, Lynne, Fredlender, Callie, Dave, Sonia, Oefner, Ruth, Fitzpatrick, Conor, Pena, Monique, Barron, Jerika, Ku, Manching, Denli, Ahmet, Kerman, Bilal, Charnay, Patrick, Kelsoe, John, Marchetto, Maria, Gage, Fred, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm - Paris Descartes), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Psychiatry, University of California [San Diego] (UC San Diego), University of California-University of California, The Salk Institute for Biological Studies, Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of neurological diseases. Here we report an efficient method for inflammation-responsive astrocyte generation from induced pluripotent stem cells (iPSCs) and embryonic stem cells. This protocol uses an intermediate glial progenitor stage and generates functional astrocytes that show levels of glutamate uptake and calcium activation comparable with those observed in human primary astrocytes. Stimulation of stem cell-derived astrocytes with interleukin-1b or tumor necrosis factor a elicits a strong and rapid pro-inflammatory response. RNA-sequencing transcriptome profiling confirmed that similar gene expression changes occurred in iPSC-derived and primary astrocytes upon stimulation with interleukin-1b. This protocol represents an important tool for modeling in-a-dish neuro-logical diseases with an inflammatory component, allowing for the investigation of the role of diseased astrocytes in neuronal degeneration.

Published
2017
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224. Impact of trauma system structure on injury outcomes : a systematic review protocol

Author

Int Injury Care Improvement Initia, Moore, Lynne, Champion, Howard, O'Reilly, Gerard, Leppäniemi, Ari, Cameron, Peter, Palmer, Cameron, Abu-Zidan, Fikri M., Gabbe, Belinda, Gaarder, Christine, Yanchar, Natalie, Stelfox, Henry Thomas, Coimbra, Raul, Kortbeek, John, Noonan, Vanessa, Gunning, Amy, Leenan, Luke, Gordon, Malcolm, Khajanchi, Monty, Shemilt, Michele, Porgo, Valerie, Turgeon, Alexis F., II kirurgian klinikka, Department of Surgery, Clinicum, and HUS Abdominal Center

Subjects
Injury outcomes, MORTALITY, 3121 General medicine, internal medicine and other clinical medicine, Trauma system, Organizational-level intervention, MAJOR TRAUMA, BURDEN, 3126 Surgery, anesthesiology, intensive care, radiology
Abstract

Background: Injury represents one of the greatest public health challenges of our time with over 5 million deaths and 100 million people temporarily or permanently disabled every year worldwide. The effectiveness of trauma systems in decreasing injury mortality and morbidity has been well demonstrated. However, the organisation of trauma care varies significantly across trauma systems and we know little about which components of trauma systems contribute to their effectiveness. The objective of the study described in this protocol is to systematically review evidence of the impact of trauma system components on clinically significant outcomes including mortality, function and disability, quality of life, and resource utilization. Methods: We will perform a systematic review of studies evaluating the association between at least one trauma system component (e.g. accreditation by a central agency, interfacility transfer agreements) and at least one injury outcome (e. g. mortality, disability, resource use). We will search MEDLINE, EMBASE, COCHRANE central, and BIOSIS/Web of Knowledge databases, thesis holdings, key injury organisation websites and conference proceedings for eligible studies. Pairs of independent reviewers will evaluate studies for eligibility and extract data from included articles. Methodological quality will be evaluated using elements of the ROBINS-I tool and the Cochrane risk of bias tool for non-randomized and randomized studies, respectively. Strength of evidence will be evaluated using the GRADE tool. Discussion: We expect to advance knowledge on the components of trauma systems that contribute to their effectiveness. This may lead to recommendations on trauma systemstructure thatwill help policy-makersmake informed decisions as to where resources should be focused. The review may also lead to specific recommendations for future research efforts.

Published
2017

225. Additional file 1: of Impact of trauma system structure on injury outcomes: a systematic review protocol

Author

Moore, Lynne, Champion, Howard, O’Reilly, Gerard, Leppaniemi, Ari, Cameron, Peter, Palmer, Cameron, Abu-Zidan, Fikri, Gabbe, Belinda, Gaarder, Christine, Yanchar, Natalie, Stelfox, Henry, Coimbra, Raul, Kortbeek, John, Noonan, Vanessa, Gunning, Amy, Leenan, Luke, Gordon, Malcolm, Khajanchi, Monty, MichèLe Shemilt, Valérie Porgo, and Turgeon, Alexis

Subjects
3. Good health
Abstract

PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist. Recommended items to address in a systematic review protocol. (PDF 104Â kb)

Published
2017
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226. Low-Value Clinical Practices in Adult Traumatic Brain Injury: An Umbrella Review.

Author

Moore, Lynne, Tardif, Pier-Alexandre, Lauzier, François, Bérubé, Melanie, Archambault, Patrick, Lamontagne, François, Chassé, Michael, Stelfox, Henry T., Gabbe, Belinda, Lecky, Fiona, Kortbeek, John, Lessard Bonaventure, Paule, Truchon, Catherine, and Turgeon, Alexis F.

Subjects
*BRAIN injuries, *THERAPEUTIC hypothermia, *DECOMPRESSIVE craniectomy, *INTRACRANIAL hypertension, *BLOOD platelet transfusion
Abstract

Despite numerous interventions and treatment options, the outcomes of traumatic brain injury (TBI) have improved little over the last 3 decades, which raises concern about the value of care in this patient population. We aimed to synthesize the evidence on 14 potentially low-value clinical practices in TBI care. Using umbrella review methodology, we identified systematic reviews evaluating the effectiveness of 14 potentially low-value practices in adults with acute TBI. We present data on methodological quality (Assessing the Methodological Quality of Systematic Reviews), reported effect sizes, and credibility of evidence (I to IV). The only clinical practice with evidence of benefit was therapeutic hypothermia (credibility of evidence II to IV). However, the most recent meta-analysis on hypothermia based on high-quality trials suggested harm (credibility of evidence IV). Meta-analyses on platelet transfusion for patients on antiplatelet therapy were all consistent with harm but were statistically non-significant. For the following practices, effect estimates were consistently close to the null: computed tomography (CT) in adults with mild TBI who are low-risk on a validated clinical decision rule; repeat CT in adults with mild TBI on anticoagulant therapy with no clinical deterioration; antibiotic prophylaxis for external ventricular drain placement; and decompressive craniectomy for refractory intracranial hypertension. We identified five clinical practices with evidence of lack of benefit or harm. However, evidence could not be considered to be strong for any clinical practice as effect measures were imprecise and heterogeneous, systematic reviews were often of low quality, and most included studies had a high risk of bias. [ABSTRACT FROM AUTHOR]

Published
2020
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227. Economic evaluation of intrahospital clinical practices in injury care: protocol for a 10-year systematic review.

Author

Conombo, Blanchard, Guertin, Jason Robert, Tardif, Pier-Alexandre, Farhat, Imen, Moore, Thomas, Bouderba, Samy, Soltana, Kahina, Archambault, Patrick, Berthelot, Simon, Lauzier, François, Turgeon, Alexis F., Stelfox, Henry Thomas, Chasse, Michaël, Hoch, Jeffrey, and Moore, Lynne

Abstract

Introduction Underuse of high-value clinical practices and overuse of low-value practices are major sources of inefficiencies in modern healthcare systems. Injuries are second only to cardiovascular disease in terms of acute care costs but data on the economic impact of clinical practices for injury admissions are lacking. This study aims to summarise evidence on the economic value of intrahospital clinical practices for injury care. Methods and analysis We will perform a systematic review to identify research articles in economic evaluation of intrahospital clinical practices in acute injury care. We will search MEDLINE and databases such as Embase, Web of Science, NHS Economic Evaluation Database, Cochrane CENTRAL, BIOSIS and CINAHL for randomised or non-randomised controlled trials and observational studies using a combination of keywords and controlled vocabulary. We will consider the following outcomes relative to economic evaluations: incremental cost-effectiveness ratio, incremental cost-utility ratio, incremental net health benefit, incremental net monetary benefit (iNMB) and incremental cost-benefit ratio. Pairs of independent reviewers will evaluate studies that meet eligibility criteria and extract data from included articles using an electronic data extraction form. All outcomes will be converted into iNMB. We will report iNMB for practices classified by type of practice (hospitalisation, consultation, diagnostic, therapeuticsurgical, therapeutic-drugs, therapeutic-other). Results obtained with a ceiling ratio of $50 000 per qualityadjusted life year gained for identified clinical practices will be summarised by charting forest plots. In line with Cochrane recommendations for systematic reviews of economic evaluations, meta-analyses will not be conducted. Ethics and dissemination Ethics approval is not required as original data will not be collected. This study will summarise existing evidence on the economic value of clinical practices in injury care. Results will be used to advance knowledge on value-based care for injury admissions and will be disseminated through a peerreviewed article, international scientific meetings and clinical and healthcare quality associations. [ABSTRACT FROM AUTHOR]

Published
2020
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228. Implementation of the best practice guidelines on geriatric trauma care: a Canadian perspective.

Author

Bérubé, Melanie, Pasquotti, Theresa, Klassen, Barbara, Brisson, Angie, Tze, Nancy, and Moore, Lynne

Subjects
DIAGNOSIS of delirium, MALNUTRITION diagnosis, WOUND care, ELDER care, ANTICOAGULANTS, FRAIL elderly, INTERNET, MEDICAL protocols, MEDICAL specialties & specialists, SURVEYS, TRAUMA centers, DECISION making in clinical medicine, EARLY ambulation (Rehabilitation)
Abstract

Background traumatic injuries are increasingly affecting older patients who are prone to more complications and poorer recovery compared to younger patients. Practices of trauma health care providers therefore need to be adapted to meet the needs of geriatric trauma patients. Objective to assess the implementation of the American College of Surgeons best practice guidelines on geriatric trauma management across level I to III Canadian trauma centres. Methods 69 decision-makers working in Canadian trauma centres were approached to complete a web-based practice survey. Percentages and means were calculated to describe the level of best practice guideline implementation. Results 50 decision-makers completed the survey for a response rate of 72%. Specialised geriatric trauma resources were utilised in 37% of centres. Implementation of mechanisms to evaluate common geriatric issues (e.g. frailty, malnutrition and delirium) varied from 28 to 78% and protocols for the optimisation of geriatric care (e.g. Beers criteria to adjust medication, anticoagulant reversal and early mobilisation) from 8 to 56%. Guideline recommendations were more often implemented in level I and level II trauma centres. The adjustment of trauma team activation criteria to the geriatric population and transition of care protocols were more frequently used by level III centres. Conclusion despite the growing number of older patients admitted in Canadian trauma centres annually, the implementation of best practice guidelines on geriatric trauma management is still limited. Prospective multicentre studies are required to develop and evaluate interdisciplinary knowledge translation initiatives that will promote the uptake of guidelines by trauma centres. [ABSTRACT FROM AUTHOR]

Published
2020
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229. Author response: Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

Author

Marchetto, Maria C, primary, Hrvoj-Mihic, Branka, additional, Kerman, Bilal E, additional, Yu, Diana X, additional, Vadodaria, Krishna C, additional, Linker, Sara B, additional, Narvaiza, Iñigo, additional, Santos, Renata, additional, Denli, Ahmet M, additional, Mendes, Ana PD, additional, Oefner, Ruth, additional, Cook, Jonathan, additional, McHenry, Lauren, additional, Grasmick, Jaeson M, additional, Heard, Kelly, additional, Fredlender, Callie, additional, Randolph-Moore, Lynne, additional, Kshirsagar, Rijul, additional, Xenitopoulos, Rea, additional, Chou, Grace, additional, Hah, Nasun, additional, Muotri, Alysson R, additional, Padmanabhan, Krishnan, additional, Semendeferi, Katerina, additional, and Gage, Fred H, additional

Published
2018
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230. Effect of psychosocial work factors on the risk of certified absences from work for a diagnosed mental health problem: a protocol of a systematic review and meta-analysis of prospective studies

Author

Duchaine, Caroline S, primary, Gilbert-Ouimet, Mahee, additional, Aubé, Karine, additional, Vezina, Michel, additional, Ndjaboue, Ruth, additional, Trudel, Xavier, additional, Lesage, Alain, additional, Moore, Lynne, additional, Laurin, Danielle, additional, and Brisson, Chantal, additional

Published
2018
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231. Depression in the First Year after Traumatic Brain Injury

Author

Ouellet, Marie-Christine, primary, Beaulieu-Bonneau, Simon, additional, Sirois, Marie-Josée, additional, Savard, Josée, additional, Turgeon, Alexis F., additional, Moore, Lynne, additional, Swaine, Bonnie, additional, Roy, Joanne, additional, Giguère, Myriam, additional, and Laviolette, Valérie, additional

Published
2018
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234. Incidence and impact of withdrawal of life-sustaining therapies in clinical trials of severe traumatic brain injury: A systematic review

Author

Leblanc, Guillaume, primary, Boutin, Amélie, additional, Shemilt, Michèle, additional, Lauzier, François, additional, Moore, Lynne, additional, Potvin, Véronique, additional, Zarychanski, Ryan, additional, Archambault, Patrick, additional, Lamontagne, François, additional, Léger, Caroline, additional, and Turgeon, Alexis F, additional

Published
2018
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235. Hemoglobin thresholds and red blood cell transfusion in adult patients with moderate or severe traumatic brain injuries: A retrospective cohort study

Author

Boutin, Amélie, primary, Moore, Lynne, additional, Green, Robert S., additional, Zarychanski, Ryan, additional, Erdogan, Mete, additional, Lauzier, François, additional, English, Shane, additional, Fergusson, Dean A., additional, Butler, Michael, additional, McIntyre, Lauralyn, additional, Chassé, Michaël, additional, Lessard Bonaventure, Paule, additional, Léger, Caroline, additional, Desjardins, Philippe, additional, Griesdale, Donald, additional, Lacroix, Jacques, additional, and Turgeon, Alexis F., additional

Published
2018
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237. Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis

Author

Mercier, Eric, primary, Tardif, Pier-Alexandre, additional, Cameron, Peter A., additional, Batomen Kuimi, Brice Lionel, additional, Émond, Marcel, additional, Moore, Lynne, additional, Mitra, Biswadev, additional, Frenette, Jérôme, additional, De Guise, Elaine, additional, Ouellet, Marie-Christine, additional, Bordeleau, Martine, additional, and Le Sage, Natalie, additional

Published
2018
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243. Deficient LEF1expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients

Author

Santos, Renata, Linker, Sara B., Stern, Shani, Mendes, Ana P. D., Shokhirev, Maxim N., Erikson, Galina, Randolph-Moore, Lynne, Racha, Vipula, Kim, Yeni, Kelsoe, John R., Bang, Anne G., Alda, M., Marchetto, Maria C., and Gage, Fred H.

Abstract

Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic episodes that affect 2% of the world population. The first-line long-term treatment for mood stabilization is lithium (Li). Induced pluripotent stem cell modeling of BD using hippocampal dentate gyrus-like neurons derived from Li-responsive (LR) and Li-non-responsive (NR) patients previously showed neuronal hyperexcitability. Li treatment reversed hyperexcitability only on the LR neurons. In this study we searched for specific targets of Li resistance in NR neurons and found that the activity of Wnt/β-catenin signaling pathway was severely affected, with a significant decrease in expression of LEF1. Li targets the Wnt/β-catenin signaling pathway by inhibiting GSK-3β and releasing β-catenin that forms a nuclear complex with TCF/LEF1, activating the Wnt/β-catenin transcription program. Therefore, we propose that downregulation of LEF1may account for Li resistance in NR neurons. Our results show that valproic acid (VPA), a drug used to treat NR patients that also acts downstream of GSK-3β, upregulated LEF1and Wnt/β-catenin gene targets, increased transcriptional activity of complex β-catenin/TCF/LEF1, and reduced excitability in NR neurons. In addition, decreasing LEF1expression in control neurons using shLEF1 caused hyperexcitability, confirming that the impact of VPA on excitability in NR neurons was connected to changes in LEF1 and in the Wnt/β-catenin pathway. Our results suggest that LEF1 may be a useful target for the discovery of new drugs for BD treatment.

Published
2021
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244. Additional file 2: of The prognostic value of magnetic resonance imaging in moderate and severe traumatic brain injury: a systematic review and meta-analysis protocol

Author

Hourmazd Haghbayan, AmÊlie Boutin, Laflamme, Mathieu, FrançOis Lauzier, MichèLe Shemilt, Moore, Lynne, Zarychanski, Ryan, Fergusson, Dean, and Turgeon, Alexis

Abstract

Evaluation of risk of bias. Description: Adapted QUIPS tool with additions from QUADAS-2. (DOCX 35 kb)

Published
2016
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245. Pediatric trauma mortality by type of designated hospital in a mature inclusive trauma system

Author

Amini Rachid, Lavoie André, Moore Lynne, Sirois Marie-Josée, and Émond Marcel

Subjects
Adult trauma center, logistic regression, pediatric trauma center, lcsh:Medical emergencies. Critical care. Intensive care. First aid, lcsh:RC86-88.9, trauma mortality
Abstract

Background : Previous studies have shown divergent results regarding the survival of injured children treated at pediatric trauma centers (PTC) and adult trauma centers (ATC). Aims : (1) To document, in a regionalized inclusive trauma system, at which level of trauma centers were the injured children treated and (2) to compare the in-hospital mortality over five levels of trauma care, ranging from pediatric level I trauma centers (PTC) to designated local trauma hospitals (level IV) for the whole study sample and for subgroups of severely injured children and head trauma. Materials and Methods : A retrospective analysis included data on 11,053 injured children (age ≤16 years) treated between April 1998 and March 2005 in 58 designated trauma hospitals in the province of Quebec, Canada. Multiple imputation was used to handle missing physiological data and multivariate logistic regression was used to compare mortality over levels of care. Results : PTC treated 52.2% of the children. Children treated at PTC were more often transferred from another hospital (73%) and were more severely injured. ATC level I, II, III and IV centers treated, respectively, 3.0%, 16.2%, 24.3% and 4.3% of children. Compared with children treated at a PTC, the risk of mortality was higher for children treated at each other ATC, i.e. level I (adjusted odds ratio [OR] = 3.1; 95% confidence interval [CI]: 1.3-7.5), level II (OR = 2.5; 95% CI: 1.3-5.0), level III (OR = 5.2; 95% CI: 2.1-13.1) and level IV (OR = 9.9; 95% CI: 2.4-41.3). Similar findings were observed among the subsamples of children who were more severely injured (Injury Severity Score >15) and who sustained head injuries. Conclusions : In our trauma system, PTC cared for more than half of the injured children and patients treated there have better survival than those treated at all other levels of ATC.

Published
2011

246. Canadian benchmarks for acute injury care

Author

Moore, Lynne, primary, Evans, David, additional, Yanchar, Natalie L., additional, Thakore, Jaimini, additional, Stelfox, Henry Thomas, additional, Hameed, Morad, additional, Simons, Richard, additional, Kortbeek, John, additional, Clément, Julien, additional, Lauzier, François, additional, and Turgeon, Alexis F., additional

Published
2017
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247. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Author

Maas, Andrew I R, primary, Menon, David K, additional, Adelson, P David, additional, Andelic, Nada, additional, Bell, Michael J, additional, Belli, Antonio, additional, Bragge, Peter, additional, Brazinova, Alexandra, additional, Büki, András, additional, Chesnut, Randall M, additional, Citerio, Giuseppe, additional, Coburn, Mark, additional, Cooper, D Jamie, additional, Crowder, A Tamara, additional, Czeiter, Endre, additional, Czosnyka, Marek, additional, Diaz-Arrastia, Ramon, additional, Dreier, Jens P, additional, Duhaime, Ann-Christine, additional, Ercole, Ari, additional, van Essen, Thomas A, additional, Feigin, Valery L, additional, Gao, Guoyi, additional, Giacino, Joseph, additional, Gonzalez-Lara, Laura E, additional, Gruen, Russell L, additional, Gupta, Deepak, additional, Hartings, Jed A, additional, Hill, Sean, additional, Jiang, Ji-yao, additional, Ketharanathan, Naomi, additional, Kompanje, Erwin J O, additional, Lanyon, Linda, additional, Laureys, Steven, additional, Lecky, Fiona, additional, Levin, Harvey, additional, Lingsma, Hester F, additional, Maegele, Marc, additional, Majdan, Marek, additional, Manley, Geoffrey, additional, Marsteller, Jill, additional, Mascia, Luciana, additional, McFadyen, Charles, additional, Mondello, Stefania, additional, Newcombe, Virginia, additional, Palotie, Aarno, additional, Parizel, Paul M, additional, Peul, Wilco, additional, Piercy, James, additional, Polinder, Suzanne, additional, Puybasset, Louis, additional, Rasmussen, Todd E, additional, Rossaint, Rolf, additional, Smielewski, Peter, additional, Söderberg, Jeannette, additional, Stanworth, Simon J, additional, Stein, Murray B, additional, von Steinbüchel, Nicole, additional, Stewart, William, additional, Steyerberg, Ewout W, additional, Stocchetti, Nino, additional, Synnot, Anneliese, additional, Te Ao, Braden, additional, Tenovuo, Olli, additional, Theadom, Alice, additional, Tibboel, Dick, additional, Videtta, Walter, additional, Wang, Kevin K W, additional, Williams, W Huw, additional, Wilson, Lindsay, additional, Yaffe, Kristine, additional, Adams, Hadie, additional, Agnoletti, Vanni, additional, Allanson, Judith, additional, Amrein, Krisztina, additional, Andaluz, Norberto, additional, Anke, Audny, additional, Antoni, Anna, additional, van As, Arjan Bastiaan, additional, Audibert, Gérard, additional, Azaševac, Antun, additional, Azouvi, Philippe, additional, Azzolini, Maria Luisa, additional, Baciu, Camelia, additional, Badenes, Rafael, additional, Barlow, Karen M, additional, Bartels, Ronald, additional, Bauerfeind, Ursula, additional, Beauchamp, Miriam, additional, Beer, Darcy, additional, Beer, Ronny, additional, Belda, Francisco Javier, additional, Bellander, Bo-Michael, additional, Bellier, Rémy, additional, Benali, Habib, additional, Benard, Thierry, additional, Beqiri, Valzerda, additional, Beretta, Luigi, additional, Bernard, Francis, additional, Bertolini, Guido, additional, Bilotta, Federico, additional, Blaabjerg, Morten, additional, den Boogert, Hugo, additional, Boutis, Kathy, additional, Bouzat, Pierre, additional, Brooks, Brian, additional, Brorsson, Camilla, additional, Bullinger, Monika, additional, Burns, Emma, additional, Calappi, Emiliana, additional, Cameron, Peter, additional, Carise, Elsa, additional, Castaño-León, Ana M, additional, Causin, Francesco, additional, Chevallard, Giorgio, additional, Chieregato, Arturo, additional, Christie, Brian, additional, Cnossen, Maryse, additional, Coles, Jonathan, additional, Collett, Johnny, additional, Della Corte, Francesco, additional, Craig, William, additional, Csato, Gabor, additional, Csomos, Akos, additional, Curry, Nicola, additional, Dahyot-Fizelier, Claire, additional, Dawes, Helen, additional, DeMatteo, Carol, additional, Depreitere, Bart, additional, Dewey, Deborah, additional, van Dijck, Jeroen, additional, Đilvesi, Đula, additional, Dippel, Diederik, additional, Dizdarevic, Kemal, additional, Donoghue, Emma, additional, Duek, Or, additional, Dulière, Guy-Loup, additional, Dzeko, Adelaida, additional, Eapen, George, additional, Emery, Carolyn A, additional, English, Shane, additional, Esser, Patrick, additional, Ezer, Erzsébet, additional, Fabricius, Martin, additional, Feng, Junfeng, additional, Fergusson, Dean, additional, Figaji, Anthony, additional, Fleming, Joanne, additional, Foks, Kelly, additional, Francony, Gilles, additional, Freedman, Stephen, additional, Freo, Ulderico, additional, Frisvold, Shirin K, additional, Gagnon, Isabelle, additional, Galanaud, Damien, additional, Gantner, Dashiell, additional, Giraud, Benoit, additional, Glocker, Ben, additional, Golubovic, Jagoš, additional, Gómez López, Pedro A, additional, Gordon, Wayne A, additional, Gradisek, Primoz, additional, Gravel, Jocelyn, additional, Griesdale, Donald, additional, Grossi, Francesca, additional, Haagsma, Juanita A, additional, Håberg, Asta Kristine, additional, Haitsma, Iain, additional, Van Hecke, Wim, additional, Helbok, Raimund, additional, Helseth, Eirik, additional, van Heugten, Caroline, additional, Hoedemaekers, Cornelia, additional, Höfer, Stefan, additional, Horton, Lindsay, additional, Hui, Jiyuan, additional, Huijben, Jilske Antonia, additional, Hutchinson, Peter J, additional, Jacobs, Bram, additional, van der Jagt, Mathieu, additional, Jankowski, Stefan, additional, Janssens, Koen, additional, Jelaca, Bojan, additional, Jones, Kelly M, additional, Kamnitsas, Konstantinos, additional, Kaps, Rafael, additional, Karan, Mladen, additional, Katila, Ari, additional, Kaukonen, Kirsi-Maija, additional, De Keyser, Véronique, additional, Kivisaari, Riku, additional, Kolias, Angelos G, additional, Kolumbán, Bálint, additional, Kolundžija, Ksenija, additional, Kondziella, Daniel, additional, Koskinen, Lars-Owe, additional, Kovács, Noémi, additional, Kramer, Andreas, additional, Kutsogiannis, Demitri, additional, Kyprianou, Theodoros, additional, Lagares, Alfonso, additional, Lamontagne, François, additional, Latini, Roberto, additional, Lauzier, François, additional, Lazar, Isaac, additional, Ledig, Christian, additional, Lefering, Rolf, additional, Legrand, Valerie, additional, Levi, Leon, additional, Lightfoot, Roger, additional, Lozano, Angels, additional, MacDonald, Stephen, additional, Major, Sebastian, additional, Manara, Alex, additional, Manhes, Pauline, additional, Maréchal, Hugues, additional, Martino, Costanza, additional, Masala, Alessandro, additional, Masson, Serge, additional, Mattern, Julia, additional, McFadyen, Bradford, additional, McMahon, Catherine, additional, Meade, Maureen, additional, Melegh, Béla, additional, Menovsky, Tomas, additional, Moore, Lynne, additional, Morgado Correia, Marta, additional, Morganti-Kossmann, Maria Cristina, additional, Muehlan, Holger, additional, Mukherjee, Pratik, additional, Murray, Lynnette, additional, van der Naalt, Joukje, additional, Negru, Ancuta, additional, Nelson, David, additional, Nieboer, Daan, additional, Noirhomme, Quentin, additional, Nyirádi, József, additional, Oddo, Mauro, additional, Okonkwo, David O, additional, Oldenbeuving, Annemarie W, additional, Ortolano, Fabrizio, additional, Osmond, Martin, additional, Payen, Jean-François, additional, Perlbarg, Vincent, additional, Persona, Paolo, additional, Pichon, Nicolas, additional, Piippo-Karjalainen, Anna, additional, Pili-Floury, Sébastien, additional, Pirinen, Matti, additional, Ple, Horia, additional, Poca, Maria Antonia, additional, Posti, Jussi, additional, Van Praag, Dominique, additional, Ptito, Alain, additional, Radoi, Andreea, additional, Ragauskas, Arminas, additional, Raj, Rahul, additional, Real, Ruben G L, additional, Reed, Nick, additional, Rhodes, Jonathan, additional, Robertson, Claudia, additional, Rocka, Saulius, additional, Røe, Cecilie, additional, Røise, Olav, additional, Roks, Gerwin, additional, Rosand, Jonathan, additional, Rosenfeld, Jeffrey V, additional, Rosenlund, Christina, additional, Rosenthal, Guy, additional, Rossi, Sandra, additional, Rueckert, Daniel, additional, de Ruiter, Godard C W, additional, Sacchi, Marco, additional, Sahakian, Barbara J, additional, Sahuquillo, Juan, additional, Sakowitz, Oliver, additional, Salvato, Gerardo, additional, Sánchez-Porras, Renán, additional, Sándor, János, additional, Sangha, Grinder, additional, Schäfer, Nadine, additional, Schmidt, Silke, additional, Schneider, Kathryn J, additional, Schnyer, David, additional, Schöhl, Herbert, additional, Schoonman, Guus G, additional, Schou, Rico Frederik, additional, Sir, Özcan, additional, Skandsen, Toril, additional, Smeets, Dirk, additional, Sorinola, Abayomi, additional, Stamatakis, Emmanuel, additional, Stevanovic, Ana, additional, Stevens, Robert D, additional, Sundström, Nina, additional, Taccone, Fabio Silvio, additional, Takala, Riikka, additional, Tanskanen, Päivi, additional, Taylor, Mark Steven, additional, Telgmann, Ralph, additional, Temkin, Nancy, additional, Teodorani, Guido, additional, Thomas, Matt, additional, Tolias, Christos M, additional, Trapani, Tony, additional, Turgeon, Alexis, additional, Vajkoczy, Peter, additional, Valadka, Alex B, additional, Valeinis, Egils, additional, Vallance, Shirley, additional, Vámos, Zoltán, additional, Vargiolu, Alessia, additional, Vega, Emmanuel, additional, Verheyden, Jan, additional, Vik, Anne, additional, Vilcinis, Rimantas, additional, Vleggeert-Lankamp, Carmen, additional, Vogt, Lidia, additional, Volovici, Victor, additional, Voormolen, Daphne C, additional, Vulekovic, Peter, additional, Vande Vyvere, Thijs, additional, Van Waesberghe, Julia, additional, Wessels, Lars, additional, Wildschut, Eno, additional, Williams, Guy, additional, Winkler, Maren K L, additional, Wolf, Stefan, additional, Wood, Gordon, additional, Xirouchaki, Nektaria, additional, Younsi, Alexander, additional, Zaaroor, Menashe, additional, Zelinkova, Veronika, additional, Zemek, Roger, additional, and Zumbo, Fabrizio, additional

Published
2017
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248. Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review

Author

Mercier, Eric, primary, Tardif, Pier-Alexandre, additional, Cameron, Peter A., additional, Émond, Marcel, additional, Moore, Lynne, additional, Mitra, Biswadev, additional, Ouellet, Marie-Christine, additional, Frenette, Jérôme, additional, de Guise, Elaine, additional, and Le Sage, Natalie, additional

Published
2017
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