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712 results on '"Mruthyunjaya, Prithvi"'

211. The Effect of Obstructive Sleep Apnea Treatment and Severity on Choroidal Thickness in Patients With Central Serous Chorioretinopathy

Author

Azad, Amee D., Davila, Jose R., Rayess, Nadim, Cao, Michelle, Mruthyunjaya, Prithvi, and Pan, Carolyn K.

Abstract

Purpose: This work aimed to analyze the association of obstructive sleep apnea (OSA) with choroidal thickness (CT) in patients with central serous chorioretinopathy (CSC).Methods: We identified patients in the Stanford Research Repository with a diagnosis of CSC and OSA. Age- and sex-matched controls with either CSC or OSA only were also identified. CT was measured at 5 points (subfoveal, and 1500 and 3000 µm nasal and temporal) by 2 graders. In addition to OSA treatment and severity, we also investigated the association of Oxygen Desaturation Index and nocturnal oxygen saturation nadir with subfoveal CT (SFCT).Results: A total of 57 patients and 72 eyes met the study inclusion criteria. The mean SFCT was significantly different across the 3 groups: OSA-only was the thinnest, followed by CSC with OSA, and CSC-only was the thickest (194.2 μm, 295.1 μm, and 357.8 μm, respectively, P< .001). SFCT was thicker in CSC with OSA compared with those with only OSA (P< .05). OSA treatment status and OSA severity did not show a significant difference in SFCT in multivariable modeling. Nocturnal oxygen saturation nadir was positively associated with SFCT, but this did not reach significance..Conclusions: SFCT is significantly different in patients with OSA alone, CSC with OSA, and CSC alone. While OSA treatment status did not demonstrate a significant difference in SFCT in this study, future studies should evaluate patients for OSA in patients known to have CSC and atypically thin CT to further investigate the novel metrics leveraged in this study.

Published
2022
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215. Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5.

Author

Binder, Christina, Mruthyunjaya, Prithvi, Schefler, Amy C., Seider, Michael I., Crilly, Richard, Hung, Arthur, Meltsner, Sheridan, Mowery, Yvonne, Kirsch, David G., Teh, Bin S., Jennelle, Richard L.S., Studenski, Matthew T., Liu, Wu, Lee, Choonik, Hayman, James A., Kastner, Brian, Hadsell, Michael, and Skalet, Alison H.

Published
2020
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216. Multi-center analysis of intraocular biopsy technique and outcomes for uveal melanoma: Ocular Oncology Study Consortium report 4.

Author

Seider, Michael I., Berry, Duncan E., Schefler, Amy C., Materin, Miguel, Stinnett, Sandra, Mruthyunjaya, Prithvi, Ocular Oncology Study Consortium, Raufi, Nikolas N., Harbour, J. William, Berry, Jesse L., Kim, Jonathan, Skalet, Alison, Miller, Audra, Liu, Tiffany, Demirci, Hakan, Ozkurt, Zeynep G., Hovland, Peter, Aaberg, Thomas, Kim, Ryan S., and Tann, Anne

Subjects
UVEA cancer, GENE expression profiling, SENTINEL lymph node biopsy, BIOPSY, ONCOLOGY, MELANOMA, SURGICAL complications, CA 125 test
Abstract

Purpose: To investigate the relationship between surgical approach for intraocular tumor biopsy of uveal melanoma and tumor morphologic features such as size and intraocular location and the effect of these variables on diagnostic yield and biopsy outcome. Methods: Consecutive patients from nine Ocular Oncology centers with uveal melanoma (UM) undergoing tumor biopsy immediately preceding I125 plaque brachytherapy with tissue sent for gene expression profiling (GEP) testing were reviewed retrospectively. Results: Three hundred sixty patients were included (50% men, mean age 60.2 years). Overall biopsy yield was 99% and 83% for GEP and cytopathology, respectively. Surgeon choice of biopsy approach (trans-vitreal vs. trans-scleral) was found to associate with both tumor location and tumor thickness. A trans-scleral rather than trans-vitreal approach was used more commonly for anteriorly located tumors (92% vs. 38% of posterior tumors, p < 0.001) and thicker tumors (86% vs. 55% of thin tumors, p < 0.001). When performing trans-vitreal biopsies, ocular oncologists with previous vitreoretinal surgery fellowship training were more likely to use wide-field surgical viewing systems, compared with indirect ophthalmoscopy (82.6% vs. 20.6%, p < 0.001). Surgical complications were rare and occurred more frequently with trans-vitreal biopsies (3.6% vs. 0.46%, p = 0.046). Conclusions: In this multi-center analysis of UM tumor biopsy, surgical yield was high for obtaining tumor tissue for GEP and cytopathology analysis with both trans-scleral and trans-vitreal techniques. Fellowship-trained ocular oncologists' preferred intraocular biopsy techniques associated strongly with tumor location, tumor thickness, and fellowship training of the surgeon. Short-term complication rates were low. [ABSTRACT FROM AUTHOR]

Published
2020
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231. Global Retinoblastoma Presentation and Analysis by National Income Level

Author

Fabian, Ido Didi, Abdallah, Elhassan, Abdullahi, Shehu U., Abdulqader, Rula A., Adamou Boubacar, Sahadatou, Ademola-Popoola, Dupe S., Adio, Adedayo, Afshar, Armin R., Aggarwal, Priyanka, Aghaji, Ada E., Ahmad, Alia, Akib, Marliyanti N. R., Al Harby, Lamis, Al Ani, Mouroge H., Alakbarova, Aygun, Portabella, Silvia Alarcón, Al-Badri, Safaa A. F., Alcasabas, Ana Patricia A., Al-Dahmash, Saad A., Alejos, Amanda, Alemany-Rubio, Ernesto, Alfa Bio, Amadou I., Alfonso Carreras, Yvania, Al-Haddad, Christiane, Al-Hussaini, Hamoud H. Y., Ali, Amany M., Alia, Donjeta B., Al-Jadiry, Mazin F., Al-Jumaly, Usama, Alkatan, Hind M., All-Eriksson, Charlotta, Al-Mafrachi, Ali A. R. M., Almeida, Argentino A., Alsawidi, Khalifa M., Al-Shaheen, Athar A. S. M., Al-Shammary, Entissar H., Amiruddin, Primawita O., Antonino, Romanzo, Astbury, Nicholas J., Atalay, Hatice T., Atchaneeyasakul, La-ongsri, Atsiaya, Rose, Attaseth, Taweevat, Aung, Than H., Ayala, Silvia, Baizakova, Baglan, Balaguer, Julia, Balayeva, Ruhengiz, Balwierz, Walentyna, Barranco, Honorio, Bascaran, Covadonga, Beck Popovic, Maja, Benavides, Raquel, Benmiloud, Sarra, Bennani Guebessi, Nissrine, Berete, Rokia C., Berry, Jesse L., Bhaduri, Anirban, Bhat, Sunil, Biddulph, Shelley J., Biewald, Eva M., Bobrova, Nadia, Boehme, Marianna, Boldt, H.C., Bonanomi, Maria Teresa B. C., Bornfeld, Norbert, Bouda, Gabrielle C., Bouguila, Hédi, Boumedane, Amaria, Brennan, Rachel C., Brichard, Bénédicte G., Buaboonnam, Jassada, Calderón-Sotelo, Patricia, Calle Jara, Doris A., Camuglia, Jayne E., Cano, Miriam R., Capra, Michael, Cassoux, Nathalie, Castela, Guilherme, Castillo, Luis, Català-Mora, Jaume, Chantada, Guillermo L., Chaudhry, Shabana, Chaugule, Sonal S., Chauhan, Argudit, Chawla, Bhavna, Chernodrinska, Violeta S., Chiwanga, Faraja S., Chuluunbat, Tsengelmaa, Cieslik, Krzysztof, Cockcroft, Ruellyn L., Comsa, Codruta, Correa, Zelia M., Correa Llano, Maria G., Corson, Timothy W., Cowan-Lyn, Kristin E., Csóka, Monika, Cui, Xuehao, Da Gama, Isac V., Dangboon, Wantanee, Das, Anirban, Das, Sima, Davanzo, Jacquelyn M., Davidson, Alan, De Potter, Patrick, Delgado, Karina Q., Demirci, Hakan, Desjardins, Laurence, Diaz Coronado, Rosdali Y., Dimaras, Helen, Dodgshun, Andrew J., Donaldson, Craig, Donato Macedo, Carla R., Dragomir, Monica D., Du, Yi, Du Bruyn, Magritha, Edison, Kemala S., Eka Sutyawan, I. Wayan, El Kettani, Asmaa, Elbahi, Amal M., Elder, James E., Elgalaly, Dina, Elhaddad, Alaa M., Elhassan, Moawia M. Ali, Elzembely, Mahmoud M., Essuman, Vera A., Evina, Ted Grimbert A., Fadoo, Zehra, Fandiño, Adriana C., Faranoush, Mohammad, Fasina, Oluyemi, Fernández, Delia D. P. G., Fernández-Teijeiro, Ana, Foster, Allen, Frenkel, Shahar, Fu, Ligia D., Fuentes-Alabi, Soad L., Gallie, Brenda L., Gandiwa, Moira, Garcia, Juan L., García Aldana, David, Gassant, Pascale Y., Geel, Jennifer A., Ghassemi, Fariba, Girón, Ana V., Gizachew, Zelalem, Goenz, Marco A., Gold, Aaron S., Goldberg-Lavid, Maya, Gole, Glen A., Gomel, Nir, Gonzalez, Efren, Gonzalez Perez, Graciela, González-Rodríguez, Liudmira, Garcia Pacheco, Henry N., Graells, Jaime, Green, Liz, Gregersen, Pernille A., Grigorovski, Nathalia D. A. K., Guedenon, Koffi M., Gunasekera, D. Sanjeeva, Gündüz, Ahmet K., Gupta, Himika, Gupta, Sanjiv, Hadjistilianou, Theodora, Hamel, Patrick, Hamid, Syed A., Hamzah, Norhafizah, Hansen, Eric D., Harbour, J. William, Hartnett, M. Elizabeth, Hasanreisoglu, Murat, Hassan, Sadiq, Hassan, Shadab, Hederova, Stanislava, Hernandez, Jose, Hernandez, Lorelay Marie Carcamo, Hessissen, Laila, Hordofa, Diriba F., Huang, Laura C., Hubbard, G. B., Hummlen, Marlies, Husakova, Kristina, Hussein Al-Janabi, Allawi N., Ida, Russo, Ilic, Vesna R., Jairaj, Vivekaraj, Jeeva, Irfan, Jenkinson, Helen, Ji, Xunda, Jo, Dong Hyun, Johnson, Kenneth P., Johnson, William J., Jones, Michael M., Kabesha, Theophile B. Amani, Kabore, Rolande L., Kaliki, Swathi, Kalinaki, Abubakar, Kantar, Mehmet, Kao, Ling-Yuh, Kardava, Tamar, Kebudi, Rejin, Kepak, Tomas, Keren-Froim, Naama, Khan, Zohora J., Khaqan, Hussain A., Khauv, Phara, Kheir, Wajiha J., Khetan, Vikas, Khodabande, Alireza, Khotenashvili, Zaza, Kim, Jonathan W., Kim, Jeong Hun, Kiratli, Hayyam, Kivelä, Tero T., Klett, Artur, Komba Palet, Jess Elio Kosh, Krivaitiene, Dalia, Kruger, Mariana, Kulvichit, Kittisak, Kuntorini, Mayasari W., Kyara, Alice, Lachmann, Eva S., Lam, Carol P. S., Lam, Geoffrey C., Larson, Scott A., Latinovic, Slobodanka, Laurenti, Kelly D., Le, Bao Han A., Lecuona, Karin, Leverant, Amy A., Li, Cairui, Limbu, Ben, Long, Quah Boon, López, Juan P., Lukamba, Robert M., Lumbroso, Livia, Luna-Fineman, Sandra, Lutfi, Delfitri, Lysytsia, Lesia, Magrath, George N., Mahajan, Amita, Majeed, Abdul Rahim, Maka, Erika, Makan, Mayuri, Makimbetov, Emil K., Manda, Chatonda, Martín Begue, Nieves, Mason, Lauren, Mason, John O., Matende, Ibrahim O., Materin, Miguel, Mattosinho, Clarissa C. D. S., Matua, Marchelo, Mayet, Ismail, Mbumba, Freddy B., McKenzie, John D., Medina-Sanson, Aurora, Mehrvar, Azim, Mengesha, Aemero A., Menon, Vikas, Mercado, Gary John V. D., Mets, Marilyn B., Midena, Edoardo, Mishra, Divyansh K. C., Mndeme, Furahini G., Mohamedani, Ahmed A., Mohammad, Mona T., Moll, Annette C., Montero, Margarita M., Morales, Rosa A., Moreira, Claude, Mruthyunjaya, Prithvi, Msina, Mchikirwa S., Msukwa, Gerald, Mudaliar, Sangeeta S., Muma, Kangwa I., Munier, Francis L., Murgoi, Gabriela, Murray, Timothy G., Musa, Kareem O., Mushtaq, Asma, Mustak, Hamzah, Muyen, Okwen M., Naidu, Gita, Nair, Akshay Gopinathan, Naumenko, Larisa, Ndoye Roth, Paule Aïda, Nency, Yetty M., Neroev, Vladimir, Ngo, Hang, Nieves, Rosa M., Nikitovic, Marina, Nkanga, Elizabeth D., Nkumbe, Henry, Nuruddin, Murtuza, Nyaywa, Mutale, Obono-Obiang, Ghislaine, Oguego, Ngozi C., Olechowski, Andrzej, Oliver, Scott C. N., Osei-Bonsu, Peter, Ossandon, Diego, Paez-Escamilla, Manuel A., Pagarra, Halimah, Painter, Sally L, Paintsil, Vivian, Paiva, Luisa, Pal, Bikramjit P., Palanivelu, Mahesh Shanmugam, Papyan, Ruzanna, Parrozzani, Raffaele, Parulekar, Manoj, Pascual Morales, Claudia R., Paton, Katherine E., Pawinska-Wasikowska, Katarzyna, Pe'er, Jacob, Peña, Armando, Peric, Sanja, Pham, Chau T. M., Philbert, Remezo, Plager, David A., Pochop, Pavel, Polania, Rodrigo A., Polyakov, Vladimir G., Pompe, Manca T., Pons, Jonathan J., Prat, Daphna, Prom, Vireak, Purwanto, Ignatius, Qadir, Ali O., Qayyum, Seema, Qian, Jiang, Rahman, Ardizal, Rahman, Salman, Rahmat, Jamalia, Rajkarnikar, Purnima, Ramanjulu, Rajesh, Ramasubramanian, Aparna, Ramirez-Ortiz, Marco A., Raobela, Léa, Rashid, Riffat, Reddy, M. Ashwin, Reich, Ehud, Renner, Lorna A., Reynders, David, Ribadu, Dahiru, Riheia, Mussagy M., Ritter-Sovinz, Petra, Rojanaporn, Duangnate, Romero, Livia, Roy, Soma R., Saab, Raya H., Saakyan, Svetlana, Sabhan, Ahmed H, Sagoo, Mandeep S., Said, Azza M. A., Saiju, Rohit, Salas, Beatriz, San Román Pacheco, Sonsoles, Sánchez, Gissela L., Sayalith, Phayvanh, Scanlan, Trish A., Schefler, Amy C., Schoeman, Judy, Sedaghat, Ahad, Seregard, Stefan, Seth, Rachna, Shah, Ankoor S., Shakoor, Shawkat A., Sharma, Manoj K., Sherief, Sadik T., Shetye, Nandan G., Shields, Carol L., Siddiqui, Sorath Noorani, Sidi Cheikh, Sidi, Silva, Sónia, Singh, Arun D., Singh, Niharika, Singh, Usha, Singha, Penny, Sitorus, Rita S., Skalet, Alison H., Soebagjo, Hendrian D., Sorochynska, Tetyana, Ssali, Grace, Stacey, Andrew W., Staffieri, Sandra E., Stahl, Erin D., Stathopoulos, Christina, Stirn Kranjc, Branka, Stones, David K., Strahlendorf, Caron, Suarez, Maria Estela Coleoni, Sultana, Sadia, Sun, Xiantao, Sundy, Meryl, Superstein, Rosanne, Supriyadi, Eddy, Surukrattanaskul, Supawan, Suzuki, Shigenobu, Svojgr, Karel, Sylla, Fatoumata, Tamamyan, Gevorg, Tan, Deborah, Tandili, Alketa, Tarrillo Leiva, Fanny F., Tashvighi, Maryam, Tateshi, Bekim, Tehuteru, Edi S., Teixeira, Luiz F., Teh, Kok Hoi, Theophile, Tuyisabe, Toledano, Helen, Trang, Doan L., Traoré, Fousseyni, Trichaiyaporn, Sumalin, Tuncer, Samuray, Tyau-Tyau, Harba, Umar, Ali B., Unal, Emel, Uner, Ogul E., Urbak, Steen F., Ushakova, Tatiana L., Usmanov, Rustam H., Valeina, Sandra, van Hoefen Wijsard, Milo, Varadisai, Adisai, Vasquez, Liliana, Vaughan, Leon O., Veleva-Krasteva, Nevyana V., Verma, Nishant, Victor, Andi A., Viksnins, Maris, Villacís Chafla, Edwin G., Vishnevskia-Dai, Vicktoria, Vora, Tushar, Wachtel, Antonio E., Wackernagel, Werner, Waddell, Keith, Wade, Patricia D., Wali, Amina H., Wang, Yi-Zhuo, Weiss, Avery, Wilson, Matthew W., Wime, Amelia D. C., Wiwatwongwana, Atchareeya, Wiwatwongwana, Damrong, Wolley Dod, Charlotte, Wongwai, Phanthipha, Xiang, Daoman, Xiao, Yishuang, Yam, Jason C., Yang, Huasheng, Yanga, Jenny M., Yaqub, Muhammad A, Yarovaya, Vera A., Yarovoy, Andrey A., Ye, Huijing, Yousef, Yacoub A., Yuliawati, Putu, Zapata López, Arturo M., Zein, Ekhtelbenina, Zhang, Chengyue, Zhang, Yi, Zhao, Junyang, Zheng, Xiaoyu, Zhilyaeva, Katsiaryna, Zia, Nida, Ziko, Othman A. O., Zondervan, Marcia, and Bowman, Richard

Abstract

IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child’s life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. OBJECTIVES: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. DESIGN, SETTING, AND PARTICIPANTS: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. MAIN OUTCOMES AND MEASURES: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. RESULTS: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle–income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle–income countries vs upper-middle–income countries and HICs, 5.74 [95% CI, 4.30-7.68]). CONCLUSIONS AND RELEVANCE: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs.

Published
2020
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241. Contributors

Author

Abràmoff, Michael D., Abrams, Gary W., Afshar, Armin R., Agarwal, Aniruddha, Agarwal, Anita, Aiello, Lloyd M., Aiello, Lloyd Paul, Albert, Daniel M., Andreoli, Michael T., Armbrust, Karen R., Aronow, Mary E., Aschbrenner, Mathew W., Ávila, Marcos, Aylward, G.W., Baldwin, Andrew J., Baldwin, Angela N., Belfort, Rubens, Jr., Bennett, Jean, Bergstrom, Chris, Besirli, Cagri G., Bessette, Angela, Bhende, Muna, Bhende, Pramod S., Binder, Susanne, Bird, Alan, Blodi, Barbara A., Blumenkranz, Mark S., Boldt, H. Culver, Borkar, Durga S., Bornfeld, Norbert, Bottoni, Ferdinando, Boulton, Michael E., Bowne, Sara J., Brady, Christopher J., Brantley, Milam A., Jr., Bressler, Neil M., Bressler, Susan B., Bringmann, Andreas, Brinton, Daniel A., Brown, Gary C., Brown, Melissa M., Brunner, Simon, Burris, Christopher K.H., Bush, Ronald A., Cao, Dingcai, Capone, Antonio, Jr., Carruthers, David, Cavallerano, Jerry D., Chakravarthy, Usha, Chan, Helen, Charles, Steve, Charteris, David G., Chen, Jeannie, Cheung, Carol Yim-lui, Chew, Emily Y., Chiang, Allen, Chiang, Michael F., Chundury, Rao V., Clegg, Dennis O., Constable, Ian J., Coscas, Gabriel, Cruess, Alan F., Cunningham, Emmett T., Jr., Curcio, Christine A., Daiger, Stephen P., Damato, Bertil E., Das, Sudipta, Davis, Janet L., Davis, Matthew D., Day, Shelley, de Amorim, Carlos Alexandre, De Potter, Patrick, de Smet, Marc D., Denniston, Alastair K., Dhaliwal, Ranjit S., Dick, Andrew D., Ding, Xiaoyan, Do, Diana V., Duker, Jay S., Duncan, Jacque L., Ehlers, Justis P., Eliott, Dean, Faia, Lisa J., Falsini, Benedetto, Fekrat, Sharon, Feldon, Steven E., Ferreyra, Henry A., Ferrington, Deborah A., Ferris, Frederick L., III, Finger, Paul T., Fisher, Steven K., Fishman, Gerald A., Fleckenstein, Monika, Flynn, Harry W., Jr., Foulds, Wallace S., Fox, Austin R., Freeman, William R., Friedlander, Martin, Frishman, Laura J., Fu, Arthur D., Gamm, David M., Garcia-Valenzuela, Enrique, Garg, Sunir J., Gaudric, Alain, Gayed, Mary, Gerding, Heinrich, Giani, Andrea, Goldberg, Morton F., Gopal, Lingam, Gordon, Caroline, Goto, Hiroshi, Gragoudas, Evangelos S., Grant, Maria B., Gregg, Ronald G., Gregory-Evans, Kevin, Groenewald, Carl, Grossniklaus, Hans E., Grover, Sandeep, Gullapalli, Vamsi K., Guthoff, Rudolf F., Gutkind, J. Silvio, Hahn, Paul, Haller, Julia A., Handa, James T., Haritoglou, Christos, Haug, Sara, Hawkins, Barbara S., He, Shikun, Herwig-Carl, Martina C., Heussen, Florian M.A., Hinton, David R., Hodgson, Nickisa M., Holz, Frank G., Houston, Samuel K., Hui, Yan-Nian, Humayun, Mark S., Ikuno, Yasushi, Isaac, David, Ishibashi, Tatsuro, Jabs, Douglas A., Jaffe, Glenn J., Jampol, Lee M., Joffe, Leonard, Johnson, Mark, Johnson, Mark W., Johnson, Robert N., Joussen, Antonia M., Julian, Karina, Jumper, J. Michael, Kaiser, Peter K., Kamermans, Maarten, Kampik, Anselm, Karanjia, Rustum, Kashani, Amir H., Keane, Pearse A., Kenney, M. Cristina, Khaderi, S. Khizer R., Khodair, Mohamad A., Kim, Ivana K., Kim, Jonathan W., Kim, Tae Wan, Kirchhof, Bernd, Kiss, Szilard, Klein, Barbara E.K., Klein, Ronald, Klufas, Michael A., Kolomeyer, Anton M., Konstantinidis, Lazaros, Kowluru, Renu, Kozak, Igor, Kuppermann, Baruch D., Kuriyan, Ajay E., Labriola, Leanne T., Lam, Dennis, Lam, Linda A., Lane, Anne Marie, Lavik, Erin B., Leary, James F., Lee, Richard W.J., Lee, Sun Young, Lee, Thomas C., Lee, Vincent, Leung, Loh-Shan B., Lewis, Geoffrey P., Leys, Anita, Li, Xiaoxin, Liakopoulos, Sandra, Lin, Chang-Ping, Lin, Phoebe, Liu, Enchun M., Liu, Shirley, Lois, Noemi, London, Nikolas J.S., Lu, Lin, Lujan, Brandon J., Luo, Yan, Lutty, Gerard A., MacLaren, Robert, Madreperla, Steven, Maguire, Albert M., Mainster, Martin A., Mansfield, Nancy C., Markoe, Arnold M., Marmor, Michael F., Martin, Daniel F., Massey, Stephen C., McCall, Maureen A., McCannel, Tara A., McCutchan, J. Allen, McDonald, H. Richard, Meier, Petra, Meredith, Travis A., Meyer, Carsten H., Mieler, William F., Miller, Joan W., Mirza, Rukhsana G., Mitter, Sayak K., Mittra, Robert A., Miyake, Yozo, Montemagno, Carlo, Moore, Anthony T., Mruthyunjaya, Prithvi, Muccioli, Cristina, Mullins, Robert F., Murphree, A. Linn, Murphy, Robert P., Murray, Philip I., Murray, Timothy G., Nagpal, Manish, Namperumalsamy, Perumalsamy, Nanda, Sumit K., Nazari, Hossein, Nguyen, Quan Dong, Nussenblatt, Robert B., Oellers, Patrick, Ohji, Masahito, Ohno-Matsui, Kyoko, Palanker, Daniel, Papakostas, Thanos D., Patel, Avni V., Patel, Purnima S., Pavlick, Anna C., Pay, S. Louise, Peereboom, David M., Pennesi, Mark E., Pepose, Jay S., Perry, Julian D., Quiram, Polly A., Raman, Rajiv, Ramchandran, Rajeev S., Rao, P. Kumar, Rao, Narsing A., Rathinam, Sivakumar R., Recchia, Franco M., Redmond, Kristin J., Reed, David, Reh, Thomas A., Reichenbach, Andreas, Rezaei, Kourous A., Rhoades, William R., Rhodes, Benjamin, Ritch, Robert, Robson, Anthony G., Rosenfeld, Philip J., Rowland, Teisha J., Rubin, Gary S., Sadda, SriniVas R., Sadun, Alfredo A., Sampath, Alapakkam P., Sangave, Amit A., Schachat, Andrew P., Schechet, Sid, Schmitz-Valckenberg, Steffen, Schwartz, Stephen G., Scott, Adrienne W., Sebag, J., Seddon, Johanna M., Seider, Michael I., Sen, H. Nida, Sepah, Yasir Jamal, Sharma, Sanjay, Sharma, Tarun, Sheu, Shwu-Jiuan, Shields, Carol L., Shields, Jerry A., Shinoda, Kei, Shukla, Dhananjay, Sieving, Paul A., Silva, Paolo S., Silveira, Claudio, Singer, Joshua, Singh, Arun D., Skalet, Alison, Skugor, Mario, Smith, Sylvia B., Sobrin, Lucia, Sodhi, Akrit, Sohn, Elliott H., Soubrane-Daguet, Gisèle, Spielberg, Leigh, Srivastava, Sunil K., Stachs, Oliver, Staurenghi, Giovanni, Sternberg, Paul, Jr., Stewart, Jay M., Stitt, Alan, Stone, Edwin M., Sugino, Ilene K., Sullivan, Lori S., Sullivan, Paul, Sun, Jennifer K., Sunness, Janet S., Symons, R.C. Andrew, Tadayoni, Ramin, Tang, Shibo, Terasaki, Hiroko, Thanos, Aristomenis, Thomas, Matthew A., Thompson, John T., Toth, Cynthia A., Toy, Brian, Trese, Michael T., Tsai, Julie H., Udar, Nitin, Ulrich, J. Niklas, Umfress, Allison C., Van Gelder, Russell N., van Meurs, Jan C., Vasconcelos-Santos, Daniel Vítor, Vavvas, Demetrios G., Vemulakonda, G. Atma, Waheed, Nadia K., Weiland, James, Weleber, Richard G., Wenick, Adam S., Wharam, Moody D., Jr., Wickham, Louisa, Wiedemann, Peter, Wiley, Henry E., Wilkinson, C.P., Wilson, David, Wolf, Sebastian, Wolfensberger, Thomas J., Wong, David, Wong, Ian Y., Wong, Tien Y., Wu, Frances, Yandiev, Yanors, Yang, Chang-Hao, Yang, Chung-May, Yannuzzi, Lawrence A., Yeh, Po-Ting, Yonekawa, Yoshihiro, Yoon, Young Hee, Yu, Hyeong Gon, Zarbin, Marco A., Zhang, Kang, Zhu, Jie, and Zinkernagel, Martin

Published
2018
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246. Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Author

Willoughby, Alex S., primary, Ying, Gui-shuang, additional, Toth, Cynthia A., additional, Maguire, Maureen G., additional, Burns, Russell E., additional, Grunwald, Juan E., additional, Daniel, Ebenezer, additional, Jaffe, Glenn J., additional, Williams, David F., additional, Beardsley, Sara, additional, Bennett, Steven, additional, Cantrill, Herbert, additional, Chan-Tram, Carmen, additional, Cheshier, Holly, additional, Damato, Kathyrn, additional, Davies, John, additional, Dev, Sundeep, additional, Enloe, Julianne, additional, Follano, Gennaro, additional, Gilbert, Peggy, additional, Johnson, Jill, additional, Jones, Tori, additional, Mayleben, Lisa, additional, Mittra, Robert, additional, Moos, Martha, additional, Neist, Ryan, additional, Oestreich, Neal, additional, Quiram, Polly, additional, Ramsay, Robert, additional, Ryan, Edwin, additional, Schindeldecker, Stephanie, additional, Snater, John, additional, Steele, Trenise, additional, Selders, Dwight, additional, Tonsfeldt, Jessica, additional, Valardi, Shelly, additional, Fish, Gary Edd, additional, Aguado, Hank A., additional, Arceneaux, Sally, additional, Arnwine, Jean, additional, Bell, Kim, additional, Bell, Tina, additional, Boleman, Bob, additional, Bradley, Patricia, additional, Callanan, David, additional, Coors, Lori, additional, Creighton, Jodi, additional, Crew, Timothy, additional, Cummings, Kimberly, additional, Dock, Christopher, additional, Duignan, Karen, additional, Fuller, Dwain, additional, Gray, Keith, additional, Hendrix, Betsy, additional, Hesse, Nicholas, additional, Jaramillo, Diana, additional, Jost, Bradley, additional, Lash, Sandy, additional, Lonsdale, Laura, additional, Mackens, Michael, additional, Mutz, Karin, additional, Potts, Michael, additional, Sanchez, Brenda, additional, Snyder, William, additional, Solley, Wayne, additional, Tarter, Carrie, additional, Wang, Robert, additional, Williams, Patrick, additional, Perkins, Stephen L., additional, Anderson, Nicholas, additional, Arnold, Ann, additional, Blais, Paul, additional, Googe, Joseph, additional, Higdon, Tina T., additional, Hunt, Cecile, additional, Johnson, Mary, additional, Miller, James, additional, Moore, Misty, additional, Morris, Charity K., additional, Morris, Christopher, additional, Oelrich, Sarah, additional, Oliver, Kristina, additional, Seitz, Vicky, additional, Whetstone, Jerry, additional, Doft, Bernard H., additional, Bedel, Jay, additional, Bergren, Robert, additional, Borthwick, Ann, additional, Conrad, Paul, additional, Fec, Amanda, additional, Fulwylie, Christina, additional, Ingram, Willia, additional, Latham, Shawnique, additional, Lester, Gina, additional, Liu, Judy, additional, Lobes, Louis, additional, Lucko, Nicole M., additional, Mechling, Holly, additional, Merlotti, Lori, additional, McBroom, Keith, additional, Olsen, Karl, additional, Puskas, Danielle, additional, Rath, Pamela, additional, Schmucker, Maria, additional, Schueckler, Lynn, additional, Schultz, Christina, additional, Shultz, Heather, additional, Steinberg, David, additional, Vyas, Avni, additional, Whale, Kim, additional, Yeckel, Kimberly, additional, Orth, David H., additional, Arredondo, Linda S., additional, Brown, Susan, additional, Ciscato, Barbara J., additional, Civantos, Joseph M., additional, Figliulo, Celeste, additional, Hasan, Sohail, additional, Kosinski, Belinda, additional, Muir, Dan, additional, Nelson, Kiersten, additional, Packo, Kirk, additional, Pollack, John S., additional, Rezaei, Kourous, additional, Shelton, Gina, additional, Townsend-Patrick, Shannya, additional, Walsh, Marian, additional, Richard McDonald, H., additional, Ansari, Nina, additional, Bye, Amanda, additional, Fu, Arthur D., additional, Grout, Sean, additional, Indermill, Chad, additional, Johnson, Robert N., additional, Michael Jumper, J., additional, Linares, Silvia, additional, Lujan, Brandon J., additional, Munden, Ames, additional, Persons, Meredith, additional, Rodriguez, Rosa, additional, Rose, Jennifer M., additional, Teske, Brandi, additional, Urias, Yesmin, additional, Young, Stephen, additional, Dreyer, Richard F., additional, Daniel, Howard, additional, Connaughton, Michele, additional, Handelman, Irvin, additional, Hobbs, Stephen, additional, Hoerner, Christine, additional, Hudson, Dawn, additional, Kopfer, Marcia, additional, Lee, Michael, additional, Lemley, Craig, additional, Logan, Joe, additional, Ma, Colin, additional, Mallet, Christophe, additional, Milliron, Amanda, additional, Peters, Mark, additional, Wohlsein, Harry, additional, Pearlman, Joel A., additional, Andrews, Margo, additional, Bartlett, Melissa, additional, Carlson, Nanette, additional, Cox, Emily, additional, Equi, Robert, additional, Gonzalez, Marta, additional, Griffin, Sophia, additional, Hogue, Fran, additional, Kennedy, Lance, additional, Kryuchkov, Lana, additional, Lopez, Carmen, additional, Lopez, Danny, additional, Luevano, Bertha, additional, McKenna, Erin, additional, Patel, Arun, additional, Reed, Brian, additional, Secor, Nyla, additional, Sison, Iris R., additional, Tsai, Tony, additional, Varghis, Nina, additional, Waller, Brooke, additional, Wendel, Robert, additional, Yebra, Reina, additional, Roth, Daniel B., additional, Deinzer, Jane, additional, Fine, Howard, additional, Green, Flory, additional, Green, Stuart, additional, Keyser, Bruce, additional, Leff, Steven, additional, Leviton, Amy, additional, Martir, Amy, additional, Mosenthine, Kristin, additional, Muscle, Starr, additional, Okoren, Linda, additional, Parker, Sandy, additional, Prenner, Jonathan, additional, Price, Nancy, additional, Rogers, Deana, additional, Rosas, Linda, additional, Schlosser, Alex, additional, Studenko, Loretta, additional, Tantum, Thea, additional, Wheatley, Harold, additional, Trese, Michael T., additional, Aaberg, Thomas, additional, Bezaire, Denis, additional, Bridges, Craig, additional, Bryant, Doug, additional, Capone, Antonio, additional, Coleman, Michelle, additional, Consolo, Christina, additional, Cook, Cindy, additional, DuLong, Candice, additional, Garretson, Bruce, additional, Grooten, Tracy, additional, Hammersley, Julie, additional, Hassan, Tarek, additional, Jessick, Heather, additional, Jones, Nanette, additional, Kinsman, Crystal, additional, Krumlauf, Jennifer, additional, Lewis, Sandy, additional, Locke, Heather, additional, Margherio, Alan, additional, Markus, Debra, additional, Marsh, Tanya, additional, Neal, Serena, additional, Noffke, Amy, additional, Oh, Kean, additional, Pence, Clarence, additional, Preston, Lisa, additional, Raphaelian, Paul, additional, Regan, Virginia R., additional, Roberts, Peter, additional, Ruby, Alan, additional, Sarrafizadeh, Ramin, additional, Scherf, Marissa, additional, Scott, Sarita, additional, Sneed, Scott, additional, Staples, Lisa, additional, Terry, Brad, additional, Trese, Matthew T., additional, Videtich, Joan, additional, Williams, George, additional, Zajechowski, Mary, additional, Joseph, Daniel P., additional, Blinder, Kevin, additional, Boyd, Lynda, additional, Buckley, Sarah, additional, Crow, Meaghan, additional, Dinatale, Amanda, additional, Engelbrecht, Nicholas, additional, Forke, Bridget, additional, Gabel, Dana, additional, Grand, Gilbert, additional, Grillion-Cerone, Jennifer, additional, Holekamp, Nancy, additional, Kelly, Charlotte, additional, Nobel, Ginny, additional, Pepple, Kelly, additional, Raeber, Matt, additional, Kumar Rao, P., additional, Ressel, Tammy, additional, Schremp, Steven, additional, Sgorlon, Merrilee, additional, Shears, Shantia, additional, Thomas, Matthew, additional, Timma, Cathy, additional, Vaughn, Annette, additional, Walters, Carolyn, additional, Weeks, Rhonda, additional, Wehmeier, Jarrod, additional, Wright, Tim, additional, Berinstein, Daniel M., additional, Ayyad, Aida, additional, Barazi, Mohammed K., additional, Bickhart, Erica, additional, Brady, Tracey, additional, Byank, Lisa, additional, Cronise, Alysia, additional, Denny, Vanessa, additional, Dunn, Courtney, additional, Flory, Michael, additional, Frantz, Robert, additional, Garfinkel, Richard A., additional, Gilbert, William, additional, Lai, Michael M., additional, Melamud, Alexander, additional, Newgen, Janine, additional, Newton, Shamekia, additional, Oliver, Debbie, additional, Osman, Michael, additional, Sanders, Reginald, additional, von Fricken, Manfred, additional, Dugel, Pravin, additional, Arenas, Sandra, additional, Balea, Gabe, additional, Bartoli, Dayna, additional, Bucci, John, additional, Cornelius, Jennifer A., additional, Dickens, Scheleen, additional, Doherty, Don, additional, Dunlap, Heather, additional, Goldenberg, David, additional, Jamal, Karim, additional, Jimenez, Norma, additional, Kavanagh, Nicole, additional, Kunimoto, Derek, additional, Martin, John, additional, Miner, Jessica, additional, Mobley, Sarah, additional, Park, Donald, additional, Quinlan, Edward, additional, Sipperley, Jack, additional, Slagle, Carol, additional, Smith, Danielle, additional, Yafchak, Miguelina, additional, Yager, Rohana, additional, Flaxel, Christina J., additional, Bailey, Steven, additional, Francis, Peter, additional, Howell, Chris, additional, Hwang, Thomas, additional, Ira, Shirley, additional, Klein, Michael, additional, Lauer, Andreas, additional, Liesegang, Teresa, additional, Lundquist, Ann, additional, Nolte, Sarah, additional, Nolte, Susan K., additional, Pickell, Scott, additional, Pope, Susan, additional, Rossi, Joseph, additional, Schain, Mitchell, additional, Steinkamp, Peter, additional, Toomey, Maureen D., additional, Vahrenwald, Debora, additional, West, Kelly, additional, Hubbard, Baker, additional, Andelman, Stacey, additional, Bergstrom, Chris, additional, Brower, Judy, additional, Cribbs, Blaine, additional, Curtis, Linda, additional, Dobbs, Jannah, additional, DuBois, Lindreth, additional, Gaultney, Jessica, additional, Gibbs, Deborah, additional, Jordan, Debora, additional, Leef, Donna, additional, Martin, Daniel F., additional, Myles, Robert, additional, Olsen, Timothy, additional, Schwent, Bryan, additional, Srivastava, Sunil, additional, Waldron, Rhonda, additional, Antoszyk, Andrew N., additional, Balasubramaniam, Uma, additional, Brooks, Danielle, additional, Brown, Justin, additional, Browning, David, additional, Clark, Loraine, additional, Ennis, Sarah, additional, Held, Susannah, additional, Helms, Jennifer V., additional, Herby, Jenna, additional, Karow, Angie, additional, Leotaud, Pearl, additional, Massimino, Caterina, additional, McClain, Donna, additional, McOwen, Michael, additional, Mindel, Jennifer, additional, Pereira, Candace, additional, Pierce, Rachel, additional, Powers, Michele, additional, Price, Angela, additional, Rohrer, Jason, additional, Sanders, Jason, additional, Avery, Robert L., additional, Avery, Kelly, additional, Basefsky, Jessica, additional, Beckner, Liz, additional, Castellarin, Alessandro, additional, Couvillion, Stephen, additional, Giust, Jack, additional, Giust, Matthew, additional, Nasir, Maan, additional, Pieramici, Dante, additional, Rabena, Melvin, additional, Risard, Sarah, additional, See, Robert, additional, Smith, Jerry, additional, Wan, Lisha, additional, Bakri, Sophie J., additional, Abu-Yaghi, Nakhleh, additional, Barkmeier, Andrew, additional, Berg, Karin, additional, Burrington, Jean, additional, Edwards, Albert, additional, Goddard, Shannon, additional, Howard, Shannon, additional, Iezzi, Raymond, additional, Lewison, Denise, additional, Link, Thomas, additional, McCannel, Colin A., additional, Overend, Joan, additional, Pach, John, additional, Ruszczyk, Margaret, additional, Shultz, Ryan, additional, Stephan, Cindy, additional, Vogen, Diane, additional, Bradford, Reagan H., additional, Bergman, Vanessa, additional, Burris, Russ, additional, Butt, Amanda, additional, Daniels, Beth, additional, Dwiggins, Connie, additional, Fransen, Stephen, additional, Guerrero, Tiffany, additional, Haivala, Darin, additional, Harris, Amy, additional, Icks, Sonny, additional, Kingsley, Ronald, additional, Redden, Lena, additional, Richmond, Rob, additional, Ross, Brittany, additional, White, Kammerin, additional, Youngberg, Misty, additional, Topping, Trexler M., additional, Bennett, Steve, additional, Chong, Sandy, additional, Ciotti, Mary, additional, Cleary, Tina, additional, Corey, Emily, additional, Donovan, Dennis, additional, Frederick, Albert, additional, Freese, Lesley, additional, Graham, Margaret, additional, Gud, Natalya, additional, Howard, Taneika, additional, Jones, Mike, additional, Morley, Michael, additional, Moses, Katie, additional, Stone, Jen, additional, Ty, Robin, additional, Wiegand, Torsten, additional, Williams, Lindsey, additional, Winder, Beth, additional, Awh, Carl C., additional, Amonette, Michelle, additional, Arrindell, Everton, additional, Beck, Dena, additional, Busbee, Brandon, additional, Dilback, Amy, additional, Downs, Sara, additional, Guidry, Allison, additional, Gutow, Gary, additional, Hardin, Jackey, additional, Hines, Sarah, additional, Hutchins, Emily, additional, LaCivita, Kim, additional, Lester, Ashley, additional, Malott, Larry, additional, McCain, MaryAnn, additional, Miracle, Jayme, additional, Moffat, Kenneth, additional, Palazzotta, Lacy, additional, Robinson, Kelly, additional, Sonkin, Peter, additional, Travis, Alecia, additional, Wallace, Roy Trent, additional, Winters, Kelly J., additional, Wray, Julia, additional, Harris, April E., additional, Bunnell, Mari, additional, Crooks, Katrina, additional, Fitzgerald, Rebecca, additional, Javid, Cameron, additional, Kew, Corin, additional, Kill, Erica, additional, Kline, Patricia, additional, Kreienkamp, Janet, additional, Martinez, Maricruz, additional, Ann Moore, Roy, additional, Saavedra, Egbert, additional, Taylor, LuAnne, additional, Walsh, Mark, additional, Wilson, Larry, additional, Ciulla, Thomas A., additional, Coyle, Ellen, additional, Harrington, Tonya, additional, Harris, Charlotte, additional, Hood, Cindi, additional, Kerr, Ingrid, additional, Maturi, Raj, additional, Moore, Dawn, additional, Morrow, Stephanie, additional, Savage, Jennifer, additional, Sink, Bethany, additional, Steele, Tom, additional, Thukral, Neelam, additional, Wilburn, Janet, additional, Walker, Joseph P., additional, Banks, Jennifer, additional, Ciampaglia, Debbie, additional, Dyshanowitz, Danielle, additional, Frederick, Jennifer, additional, Tom Ghuman, A., additional, Grodin, Richard, additional, Kiesel, Cheryl, additional, Knips, Eileen, additional, McCue, Jonathan, additional, Ortiz, Maria, additional, Peters, Crystal, additional, Raskauskas, Paul, additional, Schoeman, Etienne, additional, Sharma, Ashish, additional, Wing, Glenn, additional, Youngblood, Rebecca, additional, Chandra, Suresh R., additional, Altaweel, Michael, additional, Blodi, Barbara, additional, Burke, Kathryn, additional, Dietzman, Kristine A., additional, Gottlieb, Justin, additional, Knutson, Gene, additional, Krolnik, Denise, additional, Michael Nork, T., additional, Olson, Shelly, additional, Peterson, John, additional, Reed, Sandra, additional, Soderling, Barbara, additional, Somers, Guy, additional, Stevens, Thomas, additional, Wealti, Angela, additional, Bearelly, Srilaxmi, additional, Branchaud, Brenda, additional, Bryant, Joyce W., additional, Crowell, Sara, additional, Fekrat, Sharon, additional, Gammage, Merritt, additional, Harrison, Cheala, additional, Jones, Sarah, additional, McClain, Noreen, additional, McCuen, Brooks, additional, Mruthyunjaya, Prithvi, additional, Queen, Jeanne, additional, Sarin, Neeru, additional, Skalak, Cindy, additional, Skelly, Marriner, additional, Suner, Ivan, additional, Tomany, Ronnie, additional, Welch, Lauren, additional, Park, Susanna S., additional, Cassidy, Allison, additional, Chandra, Karishma, additional, Good, Idalew, additional, Imson, Katrina, additional, Kaur, Sashi, additional, Metzler, Helen, additional, Morse, Lawrence, additional, Redenbo, Ellen, additional, Salvador, Marisa, additional, Telander, David, additional, Thomas, Mark, additional, Wallace, Cindy, additional, Barr, Charles C., additional, Battcher, Amanda, additional, Bottorff, Michelle, additional, Chasteen, Mary, additional, Clark, Kelly, additional, Denning, Diane, additional, Schoen, Debra, additional, Schultz, Amy, additional, Tempel, Evie, additional, Wheeler, Lisa, additional, Whittington, Greg K., additional, Stone, Thomas W., additional, Blevins, Todd, additional, Buck, Michelle, additional, Cruz, Lynn, additional, Heath, Wanda, additional, Holcomb, Diana, additional, Isernhagen, Rick, additional, Kidd, Terri, additional, Kitchens, John, additional, Sears, Cathy, additional, Slade, Ed, additional, Van Arsdall, Jeanne, additional, VanHoose, Brenda, additional, Wolfe, Jenny, additional, Wood, William, additional, Zilis, John, additional, Crooks, Carol, additional, Disney, Larry, additional, Liu, Mimi, additional, Petty, Stephen, additional, Sall, Sandra, additional, Folk, James C., additional, Aly, Tracy, additional, Brotherton, Abby, additional, Critser, Douglas, additional, Hinz, Connie J., additional, Karakas, Stefani, additional, Kirschner, Valerie, additional, Lester, Cheyanne, additional, Montague, Cindy, additional, Russell, Stephen, additional, Stockman, Heather, additional, Taylor, Barbara, additional, Verdick, Randy, additional, Walshire, Jean, additional, Thompson, John T., additional, Connell, Barbara, additional, Constantine, Maryanth, additional, Davis, John L., additional, Holsapple, Gwen, additional, Hunter, Lisa, additional, Lenane, C. Nicki, additional, Mitchell, Robin, additional, Russel, Leslie, additional, Sjaarda, Raymond, additional, Brown, David M., additional, Benz, Matthew, additional, Burns, Llewellyn, additional, Carranza, JoLene G., additional, Fish, Richard, additional, Goates, Debra, additional, Hay, Shayla, additional, Jeffers, Theresa, additional, Kegley, Eric, additional, Kubecka, Dallas, additional, McGilvra, Stacy, additional, Richter, Beau, additional, Sneed, Veronica, additional, Stoever, Cary, additional, Tellez, Isabell, additional, Wong, Tien, additional, Kim, Ivana, additional, Andreoli, Christopher, additional, Barresi, Leslie, additional, Brett, Sarah, additional, Callahan, Charlene, additional, Capaccioli, Karen, additional, Carli, William, additional, Coppola, Matthew, additional, Emmanuel, Nicholas, additional, Evans, Claudia, additional, Fagan, Anna, additional, Grillo, Marcia, additional, Head, John, additional, Kieser, Troy, additional, Lee, Elaine, additional, Lord, Ursula, additional, Miretsky, Edward, additional, Palitsch, Kate, additional, Petrin, Todd, additional, Reader, Liz, additional, Reznichenko, Svetlana, additional, Robertson, Mary, additional, Smith, Justin, additional, Vavvas, Demetrios, additional, Wells, John, additional, Cahill, Cassie, additional, Lloyd Clark, W., additional, Henry, Kayla, additional, Johnson, David, additional, Miller, Peggy, additional, Oliver, LaDetrick, additional, Spivey, Robbin, additional, Swinford, Tiffany, additional, Taylor, Mallie, additional, Lambert, Michael, additional, Chase, Kris, additional, Fredrickson, Debbie, additional, Khawly, Joseph, additional, Lazarte, Valerie, additional, Lowd, Donald, additional, Miller, Pam, additional, Willis, Arthur, additional, Ferrone, Philip J., additional, Almonte, Miguel, additional, Arnott, Rachel, additional, Aviles, Ingrid, additional, Carbon, Sheri, additional, Chitjian, Michael, additional, DAmore, Kristen, additional, Elliott, Christin, additional, Fastenberg, David, additional, Golub, Barry, additional, Graham, Kenneth, additional, Lavorna, AnnMarie, additional, Murphy, Laura, additional, Palomo, Amanda, additional, Puglisi, Christina, additional, Rhee, David, additional, Romero, Juan, additional, Rosenblatt, Brett, additional, Salcedo, Glenda, additional, Schlameuss, Marianne, additional, Shakin, Eric, additional, Sookhai, Vasanti, additional, Kaiser, Richard, additional, Affel, Elizabeth, additional, Brown, Gary, additional, Centinaro, Christina, additional, Fine, Deborah, additional, Fineman, Mitchell, additional, Formoso, Michele, additional, Garg, Sunir, additional, Grande, Lisa, additional, Herbert, Carolyn, additional, Ho, Allen, additional, Hsu, Jason, additional, Jay, Maryann, additional, Lavetsky, Lisa, additional, Liebenbaum, Elaine, additional, Maguire, Joseph, additional, Monsonego, Julia, additional, O'Connor, Lucia, additional, Pierce, Lisa, additional, Regillo, Carl, additional, Rosario, Maria, additional, Spirn, Marc, additional, Vander, James, additional, Walsh, Jennifer, additional, Davidorf, Frederick H., additional, Barnett, Amanda, additional, Chang, Susie, additional, Christoforidis, John, additional, Elliott, Joy, additional, Justice, Heather, additional, Letson, Alan, additional, McKinney, Kathryne, additional, Perry, Jeri, additional, Salerno, Jill A., additional, Savage, Scott, additional, Shelley, Stephen, additional, Singerman, Lawrence J., additional, Coney, Joseph, additional, DuBois, John, additional, DuBois, Kimberly, additional, Greanoff, Gregg, additional, Himmelman, Dianne, additional, Ilc, Mary, additional, Mcnamara, Elizabeth, additional, Novak, Michael, additional, Pendergast, Scott, additional, Rath, Susan, additional, Smith-Brewer, Sheila, additional, Tanner, Vivian, additional, Weiss, Diane E., additional, Zegarra, Hernando, additional, Halperin, Lawrence, additional, Aramayo, Patricia, additional, Dhalla, Mandeep, additional, Fernandez, Brian, additional, Fernandez, Cindy, additional, Lopez, Jaclyn, additional, Lopez, Monica, additional, Mariano, Jamie, additional, Murphy, Kellie, additional, Sherley, Clifford, additional, Veksler, Rita, additional, Rahhal, Firas, additional, Babikian, Razmig, additional, Boyer, David, additional, Hami, Sepideh, additional, Kessinger, Jeff, additional, Kurokouchi, Janet, additional, Mukarram, Saba, additional, Pachman, Sarah, additional, Protacio, Eric, additional, Sierra, Julio, additional, Tabandeh, Homayoun, additional, Zamboni, Adam, additional, Elman, Michael, additional, Belz, Jennifer, additional, Butcher, Tammy, additional, Cain, Theresa, additional, Coffey, Teresa, additional, Firestone, Dena, additional, Gore, Nancy, additional, Singletary, Pamela, additional, Sotirakos, Peter, additional, Starr, JoAnn, additional, Meredith, Travis A., additional, Barnhart, Cassandra J., additional, Cantrell, Debra, additional, Esquejo-Leon, RonaLyn, additional, Houghton, Odette, additional, Kaur, Harpreet, additional, NDure, Fatoumatta, additional, Glatzer, Ronald, additional, Joffe, Leonard, additional, Schindler, Reid, additional, Fine, Stuart L., additional, Katz, Marilyn, additional, Brightwell-Arnold, Mary, additional, Glaser, Ruchira, additional, Hall, Judith, additional, Harkins, Sandra, additional, Huang, Jiayan, additional, Khvatov, Alexander, additional, McWilliams, Kathy, additional, Peskin, Ellen, additional, Pistilli, Maxwell, additional, Ryan, Susan, additional, Schnader, Allison, additional, Ying, Gui-Shuang, additional, Jaffe, Glenn, additional, Afrani-Sakyi, Jennifer, additional, Balsley, Brannon, additional, Bennett, Linda S., additional, Brooks, Adam, additional, Brower-Lingsch, Adrienne, additional, Bruce, Lori, additional, Burns, Russell, additional, Busian, Dee, additional, Choong, John, additional, Cloaninger, Lindsey, additional, DeCroos, Francis Char, additional, DuBois, Emily, additional, El-Dairi, Mays, additional, Gach, Sarah, additional, Hall, Katelyn, additional, Hawks, Terry, additional, Huang, ChengChenh, additional, Heydary, Cindy, additional, Ho, Alexander, additional, Kini, Shashi, additional, McCall, Michelle, additional, Muhammad, Daaimah, additional, Nicholson, Jayne, additional, Rieves, Pamela, additional, Shields, Kelly, additional, Specker, Adam, additional, Stinnett, Sandra, additional, Subramaniam, Sujatha, additional, Tenbrink, Patrick, additional, Toth, Cynthia, additional, Towe, Aaron, additional, Welch, Kimberly, additional, Williams, Natasha, additional, Winter, Katrina, additional, Young, Ellen, additional, Alexander, Judith, additional, Flannagan, Elisabeth, additional, Martin, E. Revell, additional, Parker, Candace, additional, Sepielli, Krista, additional, Shannon, Tom, additional, Whearry, Claressa, additional, Redford, Maryann, additional, Kopfer, Marcia R., additional, Ferris, Frederick L., additional, DuPont, Joan, additional, Friedman, Lawrence M., additional, Bressler, Susan B., additional, DeMets, David L., additional, Friedlander, Martin, additional, Johnson, Mark W., additional, Lindblad, Anne, additional, Losordo, Douglas W., additional, and Miller, Franklin G., additional

Published
2015
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250. Association between Tumor Regression Rate and Gene Expression Profile after Iodine 125 Plaque Radiotherapy for Uveal Melanoma.

Author

Mruthyunjaya, Prithvi, Seider, Michael I., Stinnett, Sandra, and Schefler, Amy

Subjects
*SPONTANEOUS cancer regression, *UVEA, *GENE expression, *CANCER genes, *CANCER radiotherapy, *TUMOR treatment, *TUMORS, THERAPEUTIC use of iodine isotopes
Abstract

Purpose Gene expression profile (GEP) testing segregates uveal melanoma (UM) into 2 main prognostic classes. It is unknown if a greater tumor regression response after iodine 125 (I 125 ) brachytherapy correlates with class 2 GEP status. The purpose of this study was to determine whether there is a significant relationship between the rate of UM height regression and GEP classification testing after I 125 plaque brachytherapy. Design Multicenter, retrospective cohort study. Participants Adult UM patients treated with I 125 plaque brachytherapy who had concurrent tumor biopsy at the time of surgery with a GEP test result from January 1, 2010 through June 30, 2014. Methods Baseline clinical data and GEP class assignments were obtained. The ultrasonographic tumor height was recorded at baseline and at 3, 6, 9, and 12 months and at the most recent final follow-up visits. Subanalysis of paired cases based on pretreatment ultrasound height was performed. Statistical analysis was performed using Wilcoxon rank-sum tests, the Fisher exact test, and Kaplan-Meier analysis. Main Outcome Measures Percentage change in tumor height from baseline. Results A total of 353 patients were included in the study. Median follow-up was 2.1 years (range, 0.5–5.3 years). Gene expression profile status was class 1 in 247 tumors (70%) and class 2 in 106 tumors (30%). Increased patient age, larger tumor dimensions, and greater tumor thickness were associated with class 2 GEP status ( P = 0.006, P < 0.001, and P < 0.001, respectively). The percentage reduction in tumor height from baseline was significantly greater in class 1 than class 2 tumors at 3 months (17.5% vs. 11.8%; P = 0.007) and 6 months (26.8% vs. 17.1%; P = 0.007), respectively, but there was no significant difference in reduction between class 1 and 2 tumors at 9 months ( P = 0.26) and 12 months ( P = 0.57) after treatment. Class 1A and 1B tumors showed similar reduction compared with class 2 tumors ( P < 0.05). Conclusions Class 1 UM tumors tend to regress more rapidly than class 2 tumors in the first 6 months after plaque radiotherapy. Class 1A and 1B tumors regress at similar rates after plaque radiotherapy. [ABSTRACT FROM AUTHOR]

Published
2017
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