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Monitoring of bioelectric signals in peripheral sympathetic nerves of small animal models is crucial to gain understanding of how the autonomic nervous system controls specific body functions related to disease states. Advances in minimally-invasive electrodes for such recordings in chronic conditions rely on electrode materials that show low-impedance ionic/electronic interfaces and elastic mechanical properties compliant with the soft and fragile nerve strands. Here we report a highly stretchable low-impedance electrode realized by microcracked gold films as metallic conductors covered with stretchable conducting polymer composite to facilitate ion-to-electron exchange. The conducting polymer composite based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) obtains its adhesive, low-impedance properties by controlling thickness, plasticizer content and deposition conditions. Atomic Force Microscopy measurements under strain show that the optimized conducting polymer coating is compliant with the micro-crack mechanics of the underlying Au-layer, necessary to absorb the tensile deformation when the electrodes are stretched. We demonstrate functionality of the stretchable electrodes by performing high quality recordings of renal sympathetic nerve activity under chronic conditions in rats. [ABSTRACT FROM AUTHOR]

Recent evidence suggested the existence of a spatial associations for music tempo with faster left-hand responses to relatively slow tempos and faster right-hand responses to relatively fast tempos. We refer to a study that systematically explored these spatial associations across different tempo ranges, revealed a clear effect only in the fast tempo range (DOI 10.3758/s13414-019-01945-8). The present study further investigated whether a spatial association exists across different tempo ranges ( i.e. , "full", "slow" or "fast" tempo range). In particular, the present study was conducted aiming (1) to test the spatial associations for tempo in the full tempo range (Experiment 1) and (2) to further investigate the occurrence of this spatial associations in the slow and fast tempo ranges (Experiment 2). Experiment 1 revealed a spatial association for tempo occurs in the full tempo range (40-200 bpm). Experiment 2 confirmed this association in the fast tempo range (133-201 bpm) but showed contradictory results in the slow tempo range (40-104 bpm). This suggests that a spatial association is plausible in the slow tempo range, although further research is needed to clarify this phenomenon., Competing Interests: Valter Prpic is an Academic Editor for PeerJ., (©2024 Mariconda et al.)

The Spatial-Numerical Association of Response Codes (SNARC) effect consists in faster left-/right-key responses to small/large numbers. (Bächtold et al., Neuropsychologia 36:731-735, 1998) reported the reversal of this effect after eliciting the context of a clockface-where small numbers are represented on the right and large numbers on the left. The present study investigates how the salience of a particular spatial-numerical context, which reflects the level of activation of the context in working memory, can alter Spatial Numerical Associations (SNAs). Four experiments presented the clockface as context and gradually increased its salience using different tasks. In the first two experiments (low salience), the context was presented at the beginning of the experiment and its retrieval was not required to perform the tasks (i.e., random number generation in Experiment 1, magnitude classification and parity judgement in Experiment 2). Results revealed regular left-to-right SNAs, unaffected by the context. In Experiment 3 (medium salience), participants performed magnitude classification and parity judgement (primary task), and a Go/No-go (secondary task) which required the retrieval of the context. Neither the SNARC effect nor a reversed-SNARC emerged, suggesting that performance was affected by the context. Finally, in Experiment 4 (high salience), the primary task required participants to classify numbers based on their position on the clockface. Results revealed a reversed SNARC, as in (Bächtold et al., Neuropsychologia 36:731-735, 1998). In conclusion, SNARC is disrupted when the context is retrieved in a secondary task, but its reversal is observed only when the context is relevant for the primary task., (© 2023. The Author(s).)

Starting approximately from the beginning of the new millennium, a series of studies highlighted that auditory information deriving from biological motion can significantly influence the behavioral, cognitive and neurophysiological processes involved in the perception and execution of complex movements. In particular, it was observed that an appropriate use of sounds deriving from one's own movement promotes improvements in the movement execution itself. Two main approaches can be used, namely the sonification one or the ecological sound one; the former is based on the conversion of physiological and/or physical movement data into sound, while the latter is based on the use of auditory recordings of movement sounds as models. In the present article, some of the main applications of both approaches-especially the latter-to the domains of sport and motor rehabilitation are reviewed, with the aim of addressing two questions: Is it possible to consider rhythm as a Gestalt of human movement? If so, is it possible to build up cognitive strategies to improve/standardize movement performance from this Gestalt? As with most topics in science, a definitive answer is not possible, yet the evidence leads us to lean toward a positive answer to both questions.

The Spatial-Numerical Association of Response Codes (SNARC) effect is evidence of an association between number magnitude and response position, with faster left-key responses to small numbers and faster right-key responses to large numbers. Similarly, recent studies revealed a SNARC-like effect for tempo, defined as the speed of an auditory sequence, with faster left-key responses to slow tempo and faster right-key responses to fast tempo. In order to address some methodological issues of previous studies, in the present study we designed an experiment to investigate the occurrence of a SNARC-like effect for tempo, employing a novel procedure in which only two auditory beats in sequence with a very short interstimulus interval were used. In the "temporal speed" condition, participants were required to judge the temporal speed (slow or fast) of the sequence. In the "interval duration" condition, participants were required to judge the duration of the interval between the two beats (short or long). The results revealed a consistent SNARC-like effect in both conditions, with faster left-hand responses to slow tempo and faster right-hand responses to fast tempo. Interestingly, the consistency of the results across the two conditions indicates that the direction of the SNARC-like effect was influenced by temporal speed even when participants were explicitly required to focus on interval duration. Overall, the current study extends previous findings by employing a new paradigm that addresses potential confounding factors and strengthens evidence for the SNARC-like effect for tempo., (© 2023. The Author(s).)

Biomaterials able to promote neuronal development and neurite outgrowth are highly desired in neural tissue engineering for the repair of damaged or disrupted neural tissue and restoring the axonal connection. For this purpose, the use of either electroactive or micro- and nanostructured materials has been separately investigated. Here, the use of a nanomodulated conductive poly(3,4-ethylendioxithiophene) poly(styrenesulfonate) (PEDOT/PSS) substrate that exhibits instructive topographical and electrical cues at the same time was investigated for the first time. In particular, thin films featuring grooves with sizes comparable with those of neuronal neurites (NanoPEDOT) were fabricated by electrochemical polymerization of PEDOT/PSS on a nanomodulated polycarbonate template. The ability of NanoPEDOT to support neuronal development and direct neurite outgrowth was demonstrated by assessing cell viability and proliferation, expression of neuronal markers, average neurite length, and direction of neuroblastoma N2A cells induced to differentiate on this novel support. In addition to the beneficial effect of the nanogrooved topography, a 30% increase was shown in the average length of neurites when differentiating cells were subjected to an electrical stimulation of a few microamperes for 6 h. The results reported here suggest a favorable effect on the neuronal development of the synergistic combination of nanotopography and electrical stimulation, supporting the use of NanoPEDOT in neural tissue engineering to promote physical and functional reconnection of impaired neural networks.

Visual hallucinations are prevalent, potentially disabling symptoms of Parkinson's Disease. Multiple impairments in bottom-up sensory processing and top-down perceptual modulation are implicated in the pathophysiology of these phenomena. In healthy individuals, visual illusions are elicited by illusory figures through parametric manipulations of geometrical configurations, contrast, color, or spatial relationships between stimuli. These illusory percepts provide insight on the physiologic processes subserving conscious and unconscious perception. In this exploratory, cross-sectional, controlled study, perceptual performance on illusory figures was assessed on 11 PD patients with hallucinations, 10 non-hallucinating PD patients, and 10 age-matched healthy individuals. In order to characterize potential neural substrates of perceptual performances, patients' brain metabolic patterns on FDG PET were also analyzed. Illusions relying on attentional modulation and global perception were attenuated in PD patients without hallucinations. This pattern was no longer recognizable in hallucinating patients. Conversely, illusory effects normally counteracted by figure to background segregation and overlapping figures recognition were enhanced in PD patients with hallucinations. FDG PET findings further suggest that perceptual differences between PD patients might be linked to abnormal top-down perceptual modulation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Cucca, Manara, Catalan, Liccari, Antonutti, Lombardo, Cenacchi, Rangan, Mingolo, Crisafulli, Dore, Murgia, Agostini and Manganotti.)

Background: Alzheimer's disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. The progressive aging of the population is expected to exacerbate this problem in the next decades. Therefore, there is an urgent need to develop quantitative diagnostic methodologies to assess the onset the disease and its progression especially in the initial phases., Results: Here we describe a novel technology to extract one of the most important molecular biomarkers of AD (Aβ 1-42 ) from a clinically-relevant volume - 100 µl - therein dispersed in a range of concentrations critical for AD early diagnosis. We demonstrate that it is possible to immunocapture Aβ 1-42 on 20 nm wide magnetic nanoparticles functionalized with hyperbranced KVLFF aptamers. Then, it is possible to transport them through microfluidic environments to a detection system where virtually all (~ 90%) the Aβ 1-42 molecules are concentrated in a dense plug of ca.50 nl. The technology is based on magnetic actuation by permanent magnets, specifically designed to generate high gradient magnetic fields. These fields, applied through submillimeter-wide channels, can concentrate, and confine magnetic nanoparticles (MNPs) into a droplet with an optimized shape that maximizes the probability of capturing highly diluted molecular biomarkers. These advancements are expected to provide efficient protocols for the concentration and manipulation of molecular biomarkers from clinical samples, enhancing the accuracy and the sensitivity of diagnostic technologies., Conclusions: This easy to automate technology allows an efficient separation of AD molecular biomarkers from volumes of biological solutions complying with the current clinical protocols and, ultimately, leads to accurate measurements of biomarkers. The technology paves a new way for a quantitative AD diagnosis at the earliest stage and it is also adaptable for the biomarker analysis of other pathologies., (© 2023. BioMed Central Ltd., part of Springer Nature.)

Both symbolic (digits) and non-symbolic (dots) numerals are spatially coded, with relatively small numbers being responded faster with a left key and large numbers being responded faster with a right key (spatial-numerical association of response codes [SNARC]). The idea of format independent SNARC seems to support the existence of a common system for symbolic and non-symbolic numerical representations, although evidence in the field is still mixed. The aim of the present study is to investigate whether symbolic and non-symbolic numerals interact in the SNARC effect when both information is simultaneously displayed. To do so, participants were presented with dice-like patterns, with digits being used instead of dots. In two separate magnitude classification tasks, participants had to respond either to the number of digits presented on the screen or to their numerical size. In the non-symbolic task, they had to judge whether the digits on the screen were more or less than three, irrespective of the numerical value of the digits. In the symbolic task, participants had to judge whether the digits on the screen were numerically smaller or larger than three, irrespective of the number of digits being present. The results show a consistent SNARC effect in the symbolic task and no effect in the non-symbolic one. Furthermore, congruency between symbolic and non-symbolic numerals did not modulate the response patterns, thus supporting the idea of independent representations and questioning some propositions of current theoretical accounts., (© 2023. The Author(s).)

Humans are predisposed to attend to emotions conveyed by facial expressions. However, compulsory attraction to emotions gets challenging when multiple emotional stimuli compete for attention, as in the emotion comparison task. In this task, participants are asked to choose which of two simultaneously presented faces displays the most positive (happiest) or negative (angriest) emotion. Participants usually respond faster to the face displaying the most intense emotion. This effect is stronger for face pairs that contain globally positive rather than negative emotional faces. Both effects are consistent with an attentional capture phenomenon driven by the perceptual salience of facial expressions. In the present experiment, we studied the temporal dynamics of attentional capture in the emotion comparison task by tracking participants' eye movements using gaze-contingent displays and responses. Our results show that, on the first fixation, participants were more accurate and dwelled longer on the left target face when it displayed the most intense emotion within the pair. On the second fixation, the pattern was reversed, with higher accuracy and longer gaze time on the right target face. Overall, our pattern of gazing behavior indicates that the typical results observed in the emotion comparison task arise from the optimal combination over time of two low-level attentional factors: the perceptual salience of emotional stimuli and the scanning habit of participants., (© 2023. The Author(s).)

The control and manipulation of superparamagnetic nanoparticles (SP-MNP) is a significant challenge and has become increasingly important in various fields, especially in biomedical research. Yet, most of applications rely on relatively large nanoparticles, 50 nm or higher, mainly due to the fact that the magnetic control of smaller MNPs is often hampered by the thermally induced Brownian motion. Here we present a magnetic device able to manipulate remotely in microfluidic environment SP-MNPs smaller than 10 nm. The device is based on a specifically tailored configuration of movable permanent magnets. The experiments performed in 500 µm capillary have shown the ability to concentrate the SP-MNPs into regions characterized by different shapes and sizes ranging from 100 to 200 µm. The results are explained by straightforward calculations and comparison between magnetic and thermal energies. We provide then a comprehensive description of the magnetic field intensity and its spatial distribution for the confinement and motion of magnetic nanoparticles for a wide range of sizes. We believe this description could be used to establish accurate and quantitative magnetic protocols not only for biomedical applications, but also for environment, food, security, and other areas., (© 2023. The Author(s).)

Recent findings on emotion comparison show a typical pattern of motor reactivity rising from attentional capture. When pairs of emotional faces are presented simultaneously, the most intense emotional face is recognized faster (Emotional Semantic Congruency-ESC effect). Furthermore, a global response speed advantage for emotional pairs with positive rather than negative average emotion intensity is observed (i.e., emotional size effect), with the choice for the happiest face resulting in a faster response than the choice for the angriest face within the pair (i.e., the happiness advantage). In two experiments, we asked whether these effects are orientation dependent, and thus linked to whether face processing is holistic or part-based. Participants were asked to choose the angriest/happiest face in emotional pairs displayed either in upright or inverted orientation and including (Experiment 1) or not including (Experiment 2) a neutral face. Beyond an overall facilitation for upright relative to inverted pairs, results showed orientation independent ESC and emotional size effects. Furthermore, the happiness advantage was present in emotional pairs of Experiment 2 but not in emotional pairs of Experiment 1, independently from face orientation. Together, results suggest that attentional capture in emotion comparison is immaterial on the type of face processing, being orientation invariant., (© 2022. The Author(s).)

The Spatial-TEmporal Association of Response Codes (STEARC) effect (Ishihara et al. in Cortex 44:454-461, 2008) is evidence that time is spatially coded along the horizontal axis. It consists in faster left-hand responses to early onset timing and faster right-hand responses to late onset timing. This effect has only been established using tasks that directly required to assess onset timing, while no studies investigated whether this association occurs automatically in the auditory modality. The current study investigated the occurrence of the STEARC effect by using a procedure similar to Ishihara and colleagues. Experiment 1 was a conceptual replication of the original study, in which participants directly discriminated the onset timing (early vs. late) of a target sound after listening to a sequence of auditory clicks. This experiment successfully replicated the STEARC effect and revealed that the onset timing is mapped categorically. In Experiments 2, 3a and 3b participants were asked to discriminate the timbre of the stimuli instead of directly assessing the onset timing. In these experiments, no STEARC effect was observed. This suggests that the auditory STEARC effect is only elicited when time is explicitly processed, thus questioning the automaticity of this phenomenon., (© 2022. The Author(s).)

Background: Due to the unfortunate pandemic situation, the phenomena of home advantage and referee bias in sports have recently received a particular research attention, especially in association football. In this regard, several studies were conducted on the last portion of the 2019-20 season: the majority of them suggests a reduction-but not the elimination-of the two phenomena, with some exceptions in which no reduction was found or, at the other extreme, the phenomena were not observed at all., Methods: The continuation of the pandemic made it possible to replicate the previous studies considering the complete 2020-21 season, thus with the important added value of having a fully balanced home/away schedule-and a higher number of matches-in the various leagues. In particular, the sample of the present study consisted of 3,898 matches from the first and second divisions of the UEFA top five ranked countries, that is, England, Spain, Italy, Germany, and France. For the home advantage, the following variables were examined: distribution of matches outcomes and home advantage for points (also for previous seasons from the 2014-15 one); ball possession; total shots; shots on goal; and corner kicks. Instead, for he referee bias, the following variables were examined: fouls; yellow cards; red cards; penalty kicks; and extra time. Chi-square tests were used to compare the distribution of matches outcomes, and t-tests to compare home vs . away data for the other variables in the 2020-21 season; Bayesian and equivalence analyses were also conducted., Results: The main results are as follows: (a) the distribution of matches outcomes in the 2020-21 season was significantly different from that of the last five complete seasons with spectators (Chi-square = 37.42, df = 2, p < 0.001), with fewer home victories and more away victories; the resulting values of the home advantage for points were 54.95% for the 2020-21 season, and 59.36% for the previous seasons; (b) for the other home advantage variables, a statistically significant overall advantage for the home team emerged; nevertheless, the strength of the differences between home and away teams was generally small (0.09 < Cohen's d < 0.17), and the corresponding means can be considered statistically equivalent for all variables but the total shots; (c) no statistically significant differences emerged between home and away teams for any of the referee bias variables., Discussion: These findings demonstrate that the absence of spectators significantly reduced the home advantage compared to previous seasons with spectators. A slight home advantage persisted in the 2020-21 season, probably due to other factors, namely, learning and travel, according to the model by Courneya & Carron (1992). Conversely, the referee bias was not observed, suggesting that it mainly derives from the pressure normally exerted by spectators., Competing Interests: Fabrizio Sors is an Academic Editor for PeerJ., (© 2022 Sors et al.)

Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder characterized by recurrent acute vaso-occlusive crises (VOCs and anemia). Gold standard treatments are hydroxycarbamide (HC) and/or different red blood cell (RBC) transfusion regimens to limit disease progression. Here, we report a retrospective study on 1,579 SCD patients (median age 23 years; 802 males/777 females), referring to 34 comprehensive Italian centers for hemoglobinopathies. Although we observed a similar proportion of Caucasian (47.9%) and African (48.7%) patients, Italian SCD patients clustered into two distinct overall groups: children of African descent and adults of Caucasian descent. We found a subset of SCD patients requiring more intensive therapy with a combination of HC plus chronic transfusion regimen, due to partial failure of HC treatment alone in preventing or reducing sickle cell-related acute manifestations. Notably, we observed a higher use of acute transfusion approaches for SCD patients of African descent when compared to Caucasian subjects. This might be related to (i) age of starting HC treatment; (ii) patients' low social status; (iii) patients' limited access to family practitioners; or (iv) discrimination. In our cohort, alloimmunization was documented in 135 patients (8.5%) and was more common in Caucasians (10.3%) than in Africans (6.6%). Alloimmunization was similar in male and female and more frequent in adults than in children. Our study reinforces the importance of donor-recipient exact matching for ABO, Rhesus, and Kell antigen systems for RBC compatibility as a winning strategy to avoid or limit alloimmunization events that negatively impact the clinical management of SCD-related severe complications., Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT03397017., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Graziadei, De Franceschi, Sainati, Venturelli, Masera, Bonomo, Vassanelli, Casale, Lodi, Voi, Rigano, Pinto, Quota, Notarangelo, Russo, Allò, Rosso, D'Ascola, Facchini, Macchi, Arcioni, Bonetti, Rossi, Sau, Campisi, Colarusso, Giona, Lisi, Giordano, Boscarol, Filosa, Marktel, Maroni, Murgia, Origa, Longo, Bortolotti, Colombatti, Di Maggio, Mariani, Piperno, Corti, Fidone, Palazzi, Badalamenti, Gianesin, Piel and Forni.)

Previous literature on the spatial-numerical association of response codes (SNARC) effect examined which factors modulate spatial-numerical associations. Recently, the role of order in the SNARC effect has been debated, and further research is necessary to better understand its contribution. The present study investigated how the order elicited by the context of the stimuli and by task demands interact. Across three experiments, we presented numbers in the context of a mobile phone keypad, an overlearned numerical display in which the ordinal position of numbers differs from the mental number line. The experiments employed three tasks with different levels of consistency with the order elicited by the context. In Experiment 1, participants judged numbers based on their spatial position on the keypad, and we found a spatial association consistent with the keypad configuration, indicating that the spatial association is driven both by the context and by the task when they consistently elicit the same order. In Experiment 2a, participants performed a magnitude classification task, and results revealed a lack of spatial associations, suggesting a conflict between the orders elicited by the context and by the task. In Experiment 2b, participants performed a parity judgment task, and the results revealed a SNARC effect, suggesting that the order elicited by the context did not modulate the spatial association. Overall, three different tasks gave rise to three different results. This shows that the context alone is not sufficient in modulating spatial-numerical associations but that the consistency between the orders elicited by context and task demands is a key factor. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The nanomechanical properties of ultrathin and nanostructured films of rigid electronic materials on soft substrates are of crucial relevance to realize materials and devices for stretchable electronics. Of particular interest are bending deformations in buckled nanometer-thick films or patterned networks of rigid materials as they can be exploited to compensate for the missing tensile elasticity. Here, we perform atomic force microscopy indentation experiments and electrical measurements to characterize the nanomechanics of ultrathin gold films on a polydimethylsiloxane (PDMS) elastomer. The measured force-indentation data can be analyzed in terms of a simple analytical model describing a bending plate on a semi-infinite soft substrate. The resulting method enables us to quantify the local Young's modulus of elasticity of the nanometer-thick film. Systematic variation of the gold layer thickness reveals the presence of a diffuse interface between the metal film and the elastomer substrate that does not contribute to the bending stiffness. The effect is associated with gold clusters that penetrate the silicone and are not directly connected to the ultrathin film. Only above a critical layer thickness, percolation of the metallic thin film happens, causing a linear increase in bending stiffness and electrical conductivity., Competing Interests: The authors declare no competing financial interest., (© 2021 The Authors. Published by American Chemical Society.)

The Impact of Event Scale-Revised (IES-R) is a widely used self-report questionnaire used to assess symptoms of posttraumatic stress disorder (PTSD). Although the IES-R has been translated and validated in multiple languages, no previous version has employed the Arabic dialect commonly spoken in Syria. The present work aimed to assess the psychometric properties of a Syrian Arabic version of the IES-R. Syrian citizens (N = 288) living in refugee camps in Turkey were administered the Syrian Arabic IES-R as part of a humanitarian aid project focused on providing psychological assistance. The data were analyzed with respect to 10 previously published factor solutions. We found that the best-fitting model was a four-factor structure that included factors involving Avoidance-Numbing, Intrusion, Hyperarousal, and Sleep Disturbance. The model showed strong measurement invariance between male and female subsamples, allowing for meaningful comparisons of the factor means. Overall, the present findings support the validity of a new version of the IES-R, which can be used by both researchers and clinicians responding to the urgent need for psychological care for Syrian refugees fleeing war-related violence., (© 2021 International Society for Traumatic Stress Studies.)

Previous work on the direct speed-intensity association (SIA) on comparative judgement tasks involved spatially distributed responses over spatially distributed stimuli with high motivational significance like facial expressions of emotions. This raises the possibility that the inferred stimulus-driven regulation of lateralized motor reactivity described by SIA, which was against the one expected on the basis of a valence-specific lateral bias, was entirely due to attentional capture from motivational significance (beyond numerical cognition). In order to establish the relevance of numerical cognition on the regulation of attentional capture we ran two complementary experiments. These involved the same direct comparison task on stimulus pairs that were fully comparable in terms of their analog representation of intensity but with different representational domain and motivational significance: symbolic magnitudes with low motivational significance in experiment 1 vs. emotions with rather high motivational significance in experiment 2. The results reveal a general SIA and point to a general mechanism regulating comparative judgements. This is based on the way spatial attention is captured toward locations that contain the stimulus which is closest in term of relative intensity to the extremal values of the series, regardless from its representational domain being it symbolic or emotional.

Reverspectives are paintings created by the English artist Patrick Hughes. They are 3D structures, for example, pyramids or prisms, which elicit an illusory depth perception that corresponds to the reverse of the physical depth layout. Rogers and Gyani state that " the perspective information provided by a simple grid of vertical and horizontal lines on a slanting surface can be just as powerful as the information provided by a rich, naturalistic scene ". The present experiment was aimed to further investigate this perspective reversal. Three independent variables were manipulated: (1) texture components (i.e., vertical, horizontal, and oblique lines components), (2) texture spatial arrangement (i.e., Hughes-type "perspective" grid vs. equidistant "no perspective" grid), and (3) illumination direction (i.e., homogeneous illumination, light from above, and light from below). The dependent variable was the "critical distance", namely, the distance between an approaching observer and the stimulus at which the illusory depth perception of concavity/convexity switched to the actual perception of convexity/concavity. The results showed that a stronger illusion is elicited by: (a) a Hughes-type texture spatial arrangement; (b) a complete grid texture composition, having both vertical and horizontal, and oblique components; and (c) illumination from below, as opposed to the condition in which light is coming from above.

The reverse contrast is a perceptual phenomenon in which the effect of the classical simultaneous lightness contrast is reversed. In classic simultaneous lightness contrast configurations, a gray surrounded by black is perceived lighter than an identical gray surrounded by white, but in the reverse contrast configurations, the perceptual outcome is the opposite: a gray surrounded by black appears darker than the same gray surrounded by white. The explanation provided for the reverse contrast (by different authors) is the belongingness of the gray targets to a more complex configuration. Different configurations show the occurrence of these phenomena; however, the factors determining this effect are not always the same. In particular, some configurations are based on both belongingness and assimilation, while one configuration is based only on belongingness. The evidence that different factors determine the reverse contrast is crucial for future research dealing with achromatic color perception and, in particular, with lightness induction phenomena.

University students are the most employed category of participants in cognitive research. However, researchers cannot fully control what their participants do the night before the experiments (e.g., consumption of alcohol) and, unless the experiment specifically concerns the effects of alcohol consumption, they often do not ask about it. Despite previous studies demonstrating that alcohol consumption leads to decrements in next-day cognitive abilities, the potential confounding effect of hangover on the validity of cognitive research has never been addressed. To address this issue, in the present study, a test-retest design was used, with two groups of university students: at T0, one group was constituted by hungover participants, while the other group was constituted by non-hungover participants; at T1, both groups were re-tested in a non-hangover state. In particular, the tests used were two versions of a parity judgment task and an arithmetic verification task. The results highlight that: (a) the response times of university students experiencing a hangover are significantly slower than those of non-hangover students and (b) the response times of hungover students are slower than those of the same students when re-tested in a non-hangover state. Additionally, it was also observed that the prevalence of hungover students in the university campus varies depending on the day of the week, with a greater chance of enrolling hungover participants on specific days. In light of the latter result, the recruitment of university students as participants in cognitive experiments might lead researchers to erroneously attribute their results to the variables they are manipulating, ignoring the effects of the potential hangover state., (Copyright © 2020 Murgia, Mingolo, Prpic, Sors, Santoro, Bilotta and Agostini.)

The water dispersion of the conductive polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonic acid) (PEDOT:PSS) is one of the most used material precursors in organic electronics also thanks to its industrial production. There is a growing interest for conductive polymers that could be alternative surrogates or replace PEDOT:PSS in some applications. A recent study by our group compared electrodeposited PEDOT:Nafion vs PEDOT:PSS in the use for neural recordings. Here, we introduce an easy and reproducible synthetic protocol to prepare a water dispersion of PEDOT:Nafion. The conductivity of the pristine material is on the order of 2 S cm -1 and was improved up to ≈6 S cm -1 upon treatment with ethylene glycol. Faster ion transfer was assessed by electrochemical impedance spectroscopy (EIS), and, interestingly, an improved adhesion was observed for coatings of the new PEDOT:Nafion dispersion on glass substrates, even without the addition of the silane cross-linker needed for PEDOT:PSS. As proof of concept, we demonstrate the use of this novel water dispersion of PEDOT:Nafion in three different organic electronic device architectures, namely, an organic electrochemical transistor (OECT), a memristor, and an artificial synapse.

Both numerical and non-numerical magnitudes elicit similar Spatial-Numerical Association of Response Codes (SNARC) effects, with small magnitudes associated with left hand responses and large magnitudes associated with right hand responses (Dehaene et al., J Exp Psychol Gen 122(3), 371, 1993). In the present study, we investigated whether the phenomenal size of visual illusions elicits the same SNARC-like effect revealed for the physical size of pictorial surfaces. Four experiments were conducted by using the Delboeuf illusion (Experiment 1) and the Kanizsa triangle illusion (Experiments 2, 3 and 4). Experiment 1 suggests the presence of a SNARC-like compatibility effect for the physical size of the inducers, while this effect was not revealed for the phenomenal size of the induced elements, possibly masked by a stronger effect of the inducers. A SNARC-like effect for the phenomenal size of the Kanizsa triangle was revealed when participants directly compared the size of the triangles (Experiment 4). Conversely, when participants performed an indirect task (orientation judgment), the SNARC-like effect was present neither for the illusory nor for the physical displays (Experiments 2 and 3). The effect revealed for the size of illusory triangles was comparable to that of real triangles with physical contours, suggesting that both phenomenal and physical magnitudes similarly elicit SNARC-like effects.

Despite the numerous benefits associated with sport practice, many children and adolescents end up quitting it year after year, with a stable dropout rate between 10 and 19 years of age. Among the causes of sport abandonment, the scientific literature highlights the presence of burnout as a fundamental factor. In this regard, the aim of the present study was to investigate the levels of the three components of sport burnout-emotional and physical exhaustion, reduced sense of accomplishment, and sport devaluation-reported by a sample of young (former) athletes, depending on whether their sport abandonment was relative (i.e., change to another sport modality) or definitive. In particular, participants were former agonist road cyclists, who have been divided into three groups on the basis of what they did after abandoning road bicycle racing, namely: (a) those still involved in cycling, either in a different specialty (e.g., mountain bike) or with a different role (e.g., coach for kids); (b) those who started practicing a different sport; and (c) those who definitively abandoned sports. The general hypothesis was that, with respect to those who changed sport and those who definitively abandoned it, those still involved in cycling would report experiencing lower levels of the three burnout components during the last year practicing it. To test this hypothesis, the Athlete Burnout Questionnaire (ABQ; Raedeke and Smith, 2001) was administered to 85 young former road cyclists. The results seem to support the hypothesis for two out of the three components, namely, emotional and physical exhaustion and sport devaluation; on the other hand, for reduced sense of accomplishment, no difference among the three groups emerged. Further research is needed to deepen the understanding of such processes, also in relation with other relevant constructs; yet, the results of the present study should already raise the awareness of sport organizations on the need to deal with this and related phenomena by adopting appropriate strategies to ensure the well-being of young athletes, thus trying to reduce early dropout., (Copyright © 2020 Sors, Tomé Lourido, Damonte, Santoro, Galmonte, Agostini and Murgia.)

People usually rely on sight to encode spatial information, becoming aware of other sensory cues when deprived of vision. In the absence of vision, it has been demonstrated that physical movements and spatial descriptions can effectively provide the spatial information that is necessary for the construction of an adequate spatial mental model. However, no study has previously compared the influence of these encoding modalities on complex movements such as human spatial navigation within real room-size environments. Thus, we investigated whether the encoding of a spatial layout through verbal cues - that is, spatial description - and motor cues - that is, physical exploration of the environment - differently affect spatial navigation within a real room-size environment, by testing blindfolded sighted (Experiment 1) and late-blind (Experiment 2) participants. Our results reveal that encoding the environment through physical movement is more effective than through verbal descriptions in supporting active navigation. Thus, our findings are in line with the studies claiming that the physical exploration of an environment enhances the development of a global spatial representation and improves spatial updating. From an applied perspective, the present results suggest that it might be possible to improve the experience for visually impaired people within a new environment by allowing them to explore it.

A common cognitive process in everyday life consists in the comparative judgements of emotions given a pair of facial expressions and the choice of the most positive/negative among them. Results from three experiments on complete-facial expressions (happy/angry) and mixed-facial expressions (neutral/happy-or-angry) pairs viewed with (Experiment 1 and 3) or without (Experiment 2) foveation and performed in conditions in which valence was either task relevant (Experiment 1 and 2) or task irrelevant (Experiment 3), show that comparative judgements of emotions are stimulus driven. Judgements' speed increased as the target absolute emotion intensity grew larger together with the average emotion of the pair, irrespective of the compatibility between the valence and the side of motor response: a semantic congruency effect in the domain of emotion. This result undermines previous interpretation of results in the context of comparative judgements based on the lateralization of emotions (e.g., SNARC-like instructional flexibility), and is fully consistent with our formalization of emotional semantic congruency: the direct Speed-Intensity Association model., (Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.)

Previous studies demonstrated that physical movement enhanced spatial updating in described environments. However, those movements were executed only after the encoding of the environment, minimally affecting the development of the spatial representation. Thus, we investigated whether and how participants could benefit from the execution of physical movement during the encoding of described environments, in terms of enhanced spatial updating. Using the judgement of relative directions task, we compared the effects of walking both during and after the description of the environment, and walking only after the description on spatial updating. Spatial updating was evaluated in terms of accuracy and response times in different headings. We found that the distribution of response times across Headings seemed not to be related to the physical movement executed, whereas the distribution of accuracy scores seemed to significantly change with the action executed. Indeed, when no movement occurred during the encoding of the environment, a preference for the learning heading was found, which did not emerge when walking during encoding occurred. Therefore, the results seem to suggest that physical movement during encoding supports the development of a heading-independent representation of described environments, reducing the anchoring for a preferred heading in favor of a global representation., (Copyright © 2017 Elsevier B.V. All rights reserved.)