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201. Reply by Authors

Author

Minervini, Andrea, primary, Campi, Riccardo, additional, Lane, Brian R., additional, De Cobelli, Ottavio, additional, Sanguedolce, Francesco, additional, Hatzichristodoulou, Georgios, additional, Antonelli, Alessandro, additional, Noyes, Sabrina, additional, Mari, Andrea, additional, Rodriguez-Faba, Oscar, additional, Keeley, Frank X., additional, Langenhuijsen, Johan, additional, Musi, Gennaro, additional, Klatte, Tobias, additional, Roscigno, Marco, additional, Akdogan, Bulent, additional, Furlan, Maria, additional, Karakoyunlu, Nihat, additional, Marszalek, Martin, additional, Capitanio, Umberto, additional, Volpe, Alessandro, additional, Brookman-May, Sabine, additional, Gschwend, Jürgen E., additional, Smaldone, Marc C., additional, Uzzo, Robert G., additional, Carini, Marco, additional, and Kutikov, Alexander, additional

Published
2020
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202. Impact of Resection Technique on Perioperative Outcomes and Surgical Margins after Partial Nephrectomy for Localized Renal Masses: A Prospective Multicenter Study

Author

Minervini, Andrea, primary, Campi, Riccardo, additional, Lane, Brian R., additional, De Cobelli, Ottavio, additional, Sanguedolce, Francesco, additional, Hatzichristodoulou, Georgios, additional, Antonelli, Alessandro, additional, Noyes, Sabrina, additional, Mari, Andrea, additional, Rodriguez-Faba, Oscar, additional, Keeley, Frank X., additional, Langenhuijsen, Johan, additional, Musi, Gennaro, additional, Klatte, Tobias, additional, Roscigno, Marco, additional, Akdogan, Bulent, additional, Furlan, Maria, additional, Karakoyunlu, Nihat, additional, Marszalek, Martin, additional, Capitanio, Umberto, additional, Volpe, Alessandro, additional, Brookman-May, Sabine, additional, Gschwend, Jürgen E., additional, Smaldone, Marc C., additional, Uzzo, Robert G., additional, Carini, Marco, additional, and Kutikov, Alexander, additional

Published
2020
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203. Predictors of Positive Surgical Margins after Robot-Assisted Partial Nephrectomy for Localized Renal Tumors: Insights from a Large Multicenter International Prospective Observational Project (The Surface-Intermediate-Base Margin Score Consortium).

Author

Di Maida, Fabrizio, Campi, Riccardo, Lane, Brian R., De Cobelli, Ottavio, Sanguedolce, Francesco, Hatzichristodoulou, Georgios, Antonelli, Alessandro, Grosso, Antonio Andrea, Noyes, Sabrina, Rodriguez-Faba, Oscar, Keeley, Frank X., Langenhuijsen, Johan, Musi, Gennaro, Klatte, Tobias, Roscigno, Marco, Akdogan, Bulent, Furlan, Maria, Simeone, Claudio, Karakoyunlu, Nihat, and Marszalek, Martin

Subjects
NEPHRECTOMY, SURGICAL margin, KIDNEY tumors, SURGICAL robots
Abstract

Background: To explore predictors of positive surgical margins (PSM) after robotic partial nephrectomy (PN) in a large multicenter international observational project, harnessing the Surface-Intermediate-Base (SIB) margin score to report the resection technique after PN in a standardized way. Methods: Data from consecutive patients with cT1-2N0M0 renal masses treated with PN from September 2014 to March 2015 at 16 tertiary referral centers and included in the SIB margin score International Consortium were prospectively collected. For the present study, only patients treated with robotic PN were included. Uni- and multivariable analysis were fitted to explore clinical and surgical predictors of PSMs after PN. Results: Overall, 289 patients were enrolled. Median (IQR) preoperative tumor size was 3.0 (2.3–4.2) cm and median (IQR) PADUA score was 8 (7–9). SIB scores of 0–2 (enucleation), 3–4 (enucleoresection) and 5 (resection) were reported in 53.3%, 27.3% and 19.4% of cases, respectively. A PSM was recorded in 18 (6.2%) patients. PSM rate was 4.5%, 11.4% and 3.6% in case of enucleation, enucleoresection and resection, respectively. Patients with PSMs had tumors with a higher rate of contact with the urinary collecting system (55.6% vs. 27.3%; p < 0.001) and a longer median warm ischemia time (22 vs. 16 min; p = 0.02) compared with patients with negative surgical margins, while no differences emerged between the two groups in terms of other tumor features (i.e., pathological diameter, PADUA score). In multivariable analysis, only enucleoresection (SIB score 3–4) versus enucleation (SIB score 0–2) was found to be an independent predictor of PSM at final pathology (HR: 2.68; 95% CI: 1.25–7.63; p = 0.04), while resection (SIB score 5) was not. Conclusions: In our experience, enucleoresection led to a higher risk of PSMs as compared to enucleation. Further studies are needed to assess the differential impacts of resection technique and surgeon's experience on margin status after robotic PN. [ABSTRACT FROM AUTHOR]

Published
2022
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204. Visual Abstract - Supplemental material for Synchronous Robot-Assisted Pulmonary and Urologic Resections for Cancer

Author

Bertolaccini, Luca, Musi, Gennaro, Galetta, Domenico, and Spaggiari, Lorenzo

Subjects
FOS: Clinical medicine, 110323 Surgery
Abstract

Supplemental material, Visual Abstract, for Synchronous Robot-Assisted Pulmonary and Urologic Resections for Cancer by Luca Bertolaccini, Gennaro Musi, Domenico Galetta and Lorenzo Spaggiari in Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

Published
2020
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206. How Can the COVID-19 Pandemic Lead to Positive Changes in Urology Residency?

Author

Busetto, Gian Maria, Del Giudice, Francesco, Mari, Andrea, Sperduti, Isabella, Longo, Nicola, Antonelli, Alessandro, Cerruto, Maria Angela, Costantini, Elisabetta, Carini, Marco, Minervini, Andrea, Rocco, Bernardo, Artibani, Walter, Porreca, Angelo, Porpiglia, Francesco, Damiano, Rocco, De Sio, Marco, Arcaniolo, Davide, Cimino, Sebastiano, Russo, Giorgio Ivan, Lucarelli, Giuseppe, Di Tonno, Pasquale, Gontero, Paolo, Soria, Francesco, Trombetta, Carlo, Liguori, Giovanni, Scarpa, Roberto Mario, Papalia, Rocco, Terrone, Carlo, Borghesi, Marco, Verze, Paolo, Madonia, Massimo, De Lisa, Antonello, Bove, Pierluigi, Guazzoni, Giorgio, Lughezzani, Giovanni, Racioppi, Marco, Di Gianfrancesco, Luca, Brunocilla, Eugenio, Schiavina, Riccardo, Simeone, Claudio, Veccia, Alessandro, Montorsi, Francesco, Briganti, Alberto, Dal Moro, Fabrizio, Pavone, Carlo, Serretta, Vincenzo, Di Stasi, Savino Mauro, Galosi, Andrea Benedetto, Schips, Luigi, Marchioni, Michele, Montanari, Emanuele, Carrieri, Giuseppe, Cormio, Luigi, Greco, Francesco, Musi, Gennaro, Maggi, Martina, Conti, Simon L, Tubaro, Andrea, De Berardinis, Ettore, Sciarra, Alessandro, Gallucci, Michele, Mirone, Vincenzo, de Cobelli, Ottavio, Ferro, Matteo, Racioppi, Marco (ORCID:0000-0001-9129-8479), Busetto, Gian Maria, Del Giudice, Francesco, Mari, Andrea, Sperduti, Isabella, Longo, Nicola, Antonelli, Alessandro, Cerruto, Maria Angela, Costantini, Elisabetta, Carini, Marco, Minervini, Andrea, Rocco, Bernardo, Artibani, Walter, Porreca, Angelo, Porpiglia, Francesco, Damiano, Rocco, De Sio, Marco, Arcaniolo, Davide, Cimino, Sebastiano, Russo, Giorgio Ivan, Lucarelli, Giuseppe, Di Tonno, Pasquale, Gontero, Paolo, Soria, Francesco, Trombetta, Carlo, Liguori, Giovanni, Scarpa, Roberto Mario, Papalia, Rocco, Terrone, Carlo, Borghesi, Marco, Verze, Paolo, Madonia, Massimo, De Lisa, Antonello, Bove, Pierluigi, Guazzoni, Giorgio, Lughezzani, Giovanni, Racioppi, Marco, Di Gianfrancesco, Luca, Brunocilla, Eugenio, Schiavina, Riccardo, Simeone, Claudio, Veccia, Alessandro, Montorsi, Francesco, Briganti, Alberto, Dal Moro, Fabrizio, Pavone, Carlo, Serretta, Vincenzo, Di Stasi, Savino Mauro, Galosi, Andrea Benedetto, Schips, Luigi, Marchioni, Michele, Montanari, Emanuele, Carrieri, Giuseppe, Cormio, Luigi, Greco, Francesco, Musi, Gennaro, Maggi, Martina, Conti, Simon L, Tubaro, Andrea, De Berardinis, Ettore, Sciarra, Alessandro, Gallucci, Michele, Mirone, Vincenzo, de Cobelli, Ottavio, Ferro, Matteo, and Racioppi, Marco (ORCID:0000-0001-9129-8479)

Abstract

The COVID-19 outbreak, in a few weeks, overloaded Italian hospitals, and the majority of medical procedures were postponed. During the pandemic, with hospital reorganization, clinical and learning activities performed by residents suffered a forced remodulation. The objective of this study is to investigate how urology training in Italy has been affected during the COVID-19 era. In this multi-academic study, we compared residents' training during the highest outbreak level with their previous activity. Overall 387 (67.1%) of the 577 Italian Urology residents participated in a 72-h anonymous online survey with 36 items sent via email. The main outcomes were clinical/surgical activities, social distancing, distance learning, and telemedicine. Clinical and learning activity was significantly reduced for the overall group, and after categorizing residents as those working only in COVID hospitals, both "junior" and "senior" residents, and those working in any of three geographical areas created (Italian regions were clustered in three major zones according to the prevalence of COVID-19). A significant decrease in outpatient activity, invasive diagnostic procedures, and endoscopic and major surgeries was reported. Through multivariate analysis, the specific year of residency has been found to be an independent predictor for all response modification. Being in zone 3 and zone 2 and having "senior" resident status were independent predictors associated with a lower reduction of the clinical and learning activity. Working in a COVID hospital and having "senior" resident status were independent predictors associated with higher reduction of the outpatient activity. Working in zone 3 and having "senior" resident status were independent predictors of lower and higher outpatient surgical activity, respectively. Working in a COVID hospital was an independent predictor associated with robotic surgical activity. The majority of residents reported that distance teaching and multidis

Published
2020

207. Increased Body Mass Index Is a Risk Factor for Poor Clinical Outcomes after Radical Prostatectomy in Men with International Society of Urological Pathology Grade Group 1 Prostate Cancer Diagnosed with Systematic Biopsies.

Author

Ferro, Matteo, Terracciano, Daniela, Musi, Gennaro, de Cobelli, Ottavio, Vartolomei, Mihai Dorin, Damiano, Rocco, Cantiello, Francesco, Buonerba, Carlo, Morelli, Michele, Mistretta, Francesco Alessandro, Luzzago, Stefano, Perdonà, Sisto, Del Prete, Paola, Del Giudice, Francesco, Busetto, Gian Maria, Porreca, Angelo, Autorino, Riccardo, Manfredi, Matteo, Porpiglia, Francesco, and Muto, Matteo

Subjects
PROSTATE cancer, BODY mass index, RADICAL prostatectomy, SURGICAL margin, CANCER diagnosis, PROSTATE-specific antigen
Abstract

Introduction: The association between obesity and clinically significant prostate cancer (PCa) is still a matter of debate. In this study, we evaluated the effect of body mass index (BMI) on the prediction of pathological unfavorable disease (UD), positive surgical margins (PSMs), and biochemical recurrence (BCR) in patients with clinically localized (≤cT2c) International Society of Urological Pathology (ISUP) grade group 1 PCa at biopsy. Methods: 427 patients with ISUP grade group 1 PCa who have undergone radical prostatectomy and BMI evaluation were included. The outcome of interest was the presence of UD (defined as ISUP grade group ≥3 and pT ≥3a), PSM, and BCR. Results: Statistically significant differences resulted in comparing BMI with prostate-specific antigen (PSA) and serum testosterone levels (both p < 0.0001). Patients with UD and PSM had higher BMI values (p < 0.0001 and p = 0.006, respectively). BCR-free survival was significantly decreased in patients with higher BMI values (p < 0.0001). BMI was an independent risk factor for BCR and PSM. Receiver-operating characteristic analysis testing PSA accuracy in different BMI groups, showed that PSA had a reduced predictive value (area under the curve [AUC] = 0.535; 95% confidence interval [CI] = 0.422–0.646), in obese men compared to overweight (AUC = 0.664; 95% CI = 0.598–0.725) and normal weight patients (AUC = 0.721; 95% CI = 0.660–0.777). Conclusion: Our findings show that increased BMI is a significant predictor of UD and PSM at RP in patients with preoperative low-to intermediate-risk diseases, suggesting that BMI evaluation may be useful in a clinical setting to identify patients with favorable preoperative disease characteristics harboring high-risk PCa. [ABSTRACT FROM AUTHOR]

Published
2022
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209. Beyond PSA: The Role of Prostate Health Index (phi)

Author

Ferro, Matteo, primary, De Cobelli, Ottavio, additional, Lucarelli, Giuseppe, additional, Porreca, Angelo, additional, Busetto, Gian Maria, additional, Cantiello, Francesco, additional, Damiano, Rocco, additional, Autorino, Riccardo, additional, Musi, Gennaro, additional, Vartolomei, Mihai Dorin, additional, Muto, Matteo, additional, and Terracciano, Daniela, additional

Published
2020
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210. Robot-assisted inguinal lymphadenectomy: preliminary experience and perioperative outcomes from an Italian referral center

Author

Cozzi, Gabriele, primary, Musi, Gennaro, additional, Ferro, Matteo, additional, Prestianni, Pierpaolo, additional, Bianchi, Roberto, additional, Giulia, Garelli, additional, Alessandro, Mistretta Francesco, additional, Luzzago, Stefano, additional, Pennacchioli, Elisabetta, additional, and Cobelli, Ottavio de, additional

Published
2020
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211. SARS-CoV-2 Infection and High-Risk Non-Muscle-Invasive Bladder Cancer: Are There Any Common Features?

Author

Busetto, Gian Maria, primary, Porreca, Angelo, additional, Del Giudice, Francesco, additional, Maggi, Martina, additional, D'Agostino, Daniele, additional, Romagnoli, Daniele, additional, Musi, Gennaro, additional, Lucarelli, Giuseppe, additional, Palmer, Katie, additional, Colonna di Paliano, Ascanio, additional, Muto, Matteo, additional, Hurle, Rodolfo, additional, Terracciano, Daniela, additional, de Cobelli, Ottavio, additional, Sciarra, Alessandro, additional, De Berardinis, Ettore, additional, and Ferro, Matteo, additional

Published
2020
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212. Correction: Confirmatory multiparametric magnetic resonance imaging at recruitment confers prolonged stay in active surveillance and decreases the rate of upgrading at follow-up

Author

Luzzago, Stefano, primary, Catellani, Michele, additional, Di Trapani, Ettore, additional, Cozzi, Gabriele, additional, Mistretta, Francesco A., additional, Bianchi, Roberto, additional, Pricolo, Paola, additional, Conti, Andrea, additional, Ancona, Eleonora, additional, Piacentini, Nicolò, additional, Alessi, Sarah, additional, Renne, Giuseppe, additional, Ferro, Matteo, additional, Matei, Deliu-Victor, additional, Musi, Gennaro, additional, Jereczek-Fossa, Barbara Alicja, additional, Petralia, Giuseppe, additional, and de Cobelli, Ottavio, additional

Published
2019
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213. Comparison of Outcomes and Toxicity Between Extreme and Moderate Radiation Therapy Hypofractionation in Localized Prostate Cancer: A Propensity Score Analysis

Author

Marvaso, Giulia, primary, Ciardo, Delia, additional, Gandini, Sara, additional, Riva, Giulia, additional, Frigo, Emanuele, additional, Volpe, Stefania, additional, Fodor, Cristiana, additional, Zerini, Dario, additional, Rojas, Damaris Patricia, additional, Comi, Stefania, additional, Cambria, Raffaella, additional, Cattani, Federica, additional, Musi, Gennaro, additional, De Cobelli, Ottavio, additional, Orecchia, Roberto, additional, and Jereczek-Fossa, Barbara A., additional

Published
2019
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214. Radioablation +/− hormonotherapy for prostate cancer oligorecurrences (Radiosa trial): potential of imaging and biology (AIRC IG-22159)

Author

Marvaso, Giulia, primary, Ciardo, Delia, additional, Corrao, Giulia, additional, Gandini, Sara, additional, Fodor, Cristiana, additional, Zerini, Dario, additional, Rojas, Damaris Patricia, additional, Augugliaro, Matteo, additional, Bonizzi, Giuseppina, additional, Pece, Salvatore, additional, Cattani, Federica, additional, Mazzocco, Ketti, additional, Mistretta, Francesco Alessandro, additional, Musi, Gennaro, additional, Alessi, Sarah, additional, Petralia, Giuseppe, additional, Pravettoni, Gabriella, additional, De Cobelli, Ottavio, additional, Di Fiore, Pier Paolo, additional, Viale, Giuseppe, additional, Orecchia, Roberto, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2019
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215. Sexual function recovery after robot‐assisted radical prostatectomy: Outcomes from an Italian referral centre and predicting nomogram

Author

Cozzi, Gabriele, primary, Musi, Gennaro, additional, Monturano, Massimo, additional, Bagnardi, Vincenzo, additional, Frassoni, Samuele, additional, Jereczek‐Fossa, Barbara A., additional, Ferro, Matteo, additional, Bianchi, Roberto, additional, Mistretta, Francesco A., additional, and Cobelli, Ottavio, additional

Published
2019
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216. Conditional survival of patients with stage I–III squamous cell carcinoma of the penis: temporal changes in cancer-specific mortality

Author

Mistretta, Francesco Alessandro, primary, Palumbo, Carlotta, additional, Knipper, Sophie, additional, Mazzone, Elio, additional, Pecoraro, Angela, additional, Tian, Zhe, additional, Musi, Gennaro, additional, Perrotte, Paul, additional, Montanari, Emanuele, additional, Shariat, Shahrokh F., additional, Saad, Fred, additional, Briganti, Alberto, additional, de Cobelli, Ottavio, additional, and Karakiewicz, Pierre I., additional

Published
2019
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217. Confirmatory multiparametric magnetic resonance imaging at recruitment confers prolonged stay in active surveillance and decreases the rate of upgrading at follow-up

Author

Luzzago, Stefano, primary, Catellani, Michele, additional, Di Trapani, Ettore, additional, Cozzi, Gabriele, additional, Mistretta, Francesco A., additional, Bianchi, Roberto, additional, Pricolo, Paola, additional, Conti, Andrea, additional, Ancona, Eleonora, additional, Piacentini, Nicolò, additional, Alessi, Sarah, additional, Renne, Giuseppe, additional, Ferro, Matteo, additional, Matei, Deliu-Victor, additional, Musi, Gennaro, additional, Jereczek-Fossa, Barbara Alicja, additional, Petralia, Giuseppe, additional, and de Cobelli, Ottavio, additional

Published
2019
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218. MP32-17 CLINICAL RECURRENCE AFTER RADICAL CYSTECTOMY FOR BLADDER CANCER, DEFINING OPTIMAL SURVEILLANCE AFTER SURGERY

Author

moschini*, Marco, primary, Zamboni, Stefania, additional, Karnes, Jeffrey R., additional, Montorsi, Francesco, additional, Briganti, Alberto, additional, Colombo, Renzo, additional, Gallina, Andrea, additional, Mattei, Agostino, additional, Baumeister, Philipp, additional, di Trapani, Ettore, additional, Cobelli, Ottavio De, additional, Musi, Gennaro, additional, Antonelli, Alessandro, additional, Simeone, Claudio, additional, Boeri, Luca, additional, Soligo, Matteo, additional, Simone, Giuseppe, additional, Gallucci, Michele, additional, Aziz, Atiqullah, additional, Xylinas, Evanguelos, additional, and Shariat, Shahrokh F., additional

Published
2019
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219. MP32-16 INCIDENCE AND IMPACT OF HISTOLOGICAL VARIANTS ON SURVIVAL IN CANDIDATES FOR RADICAL CYSTECTOMY: RESULTS FROM A MULTICENTER COLLABORATION

Author

Moschini*, Marco, primary, Zamboni, Stefania, additional, Karnes, Jeffrey R., additional, Roghmann, Florian, additional, Tully, Karl, additional, Sargos, Paul, additional, Montorsi, Francesco, additional, Briganti, Alberto, additional, Colombo, Renzo, additional, Gallina, Andrea, additional, Mattei, Agostino, additional, Baumeister, Philipp, additional, Rink, Michael, additional, Poyet, Cedric, additional, Saba, Karim, additional, Trapani, Ettore Di, additional, De Cobelli, Ottavio, additional, Musi, Gennaro, additional, Antonelli, Alessandro, additional, Simeone, Claudio, additional, Soligo, Matteo, additional, Boeri, Luca, additional, Simone, Giuseppe, additional, Gallucci, Michele, additional, Aziz, Atiqullah, additional, Xylinas, Evanguelos, additional, and Shariat, Shahrokh F., additional

Published
2019
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220. Robot assisted radical prostatectomy in kidney transplant recipients: surgical, oncological and functional outcomes of two different robotic approaches

Author

Mistretta, Francesco Alessandro, primary, Galfano, Antonio, additional, Trapani, Ettore Di, additional, Trapani, Dario Di, additional, Russo, Andrea, additional, Secco, Silvia, additional, Ferro, Matteo, additional, Musi, Gennaro, additional, Bocciardi, Aldo Massimo, additional, and Cobelli, Ottavio de, additional

Published
2019
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221. Circulating preoperative testosterone level predicts unfavourable disease at radical prostatectomy in men with International Society of Urological Pathology Grade Group 1 prostate cancer diagnosed with systematic biopsies.

Author

Ferro, Matteo, Lucarelli, Giuseppe, de Cobelli, Ottavio, Vartolomei, Mihai Dorin, Damiano, Rocco, Cantiello, Francesco, Crocerossa, Fabio, Perdonà, Sisto, Del Prete, Paola, Cordima, Giovanni, Musi, Gennaro, Del Giudice, Francesco, Busetto, Gian Maria, Chung, Benjamin I., Porreca, Angelo, Ditonno, Pasquale, Battaglia, Michele, and Terracciano, Daniela

Subjects
RADICAL prostatectomy, TESTOSTERONE, PROSTATE cancer, CANCER diagnosis, RECEIVER operating characteristic curves, PATHOLOGY
Abstract

Purpose: The association between circulating total testosterone (T) levels and clinically significant PCa is still a matter of debate. In this study, we evaluated whether serum testosterone levels may have a role in predicting unfavorable disease (UD) and biochemical recurrence (BCR) in patients with clinically localized (≤ cT2c) ISUP grade group 1 PCa at biopsy. Methods: 408 patients with ISUP grade group 1 prostate cancer, undergone to radical prostatectomy and T measurement were included. The outcome of interest was the presence of unfavourable disease (UD) defined as ISUP grade group ≥ 3 and/or pT ≥ 3a. Results: Statistically significant differences resulted between serum testosterone values and ISUP grade groups (P < 0.0001). Significant correlation was found analyzing testosterone values versus age (P < 0.0001), and versus PSA (P = 0.008). BCR-free survival was significantly decreased in patients with low levels of testosterone (P = 0.005). These findings were confirmed also in the ISUP 1–2 subgroups (P = 0.01). ROC curve analysis showed that T outperformed PSA in predicting UD (AUC 0.718 vs AUC 0.525; P < 0.001) and was and independent risk factor for BCR. Conclusion: Our findings suggested that circulating total T was a significant predictor of UD at RP in patients with preoperative low- to intermediate-risk diseases, confirming the potential role of circulating androgens in preoperative risk assessment of PCa patients. [ABSTRACT FROM AUTHOR]

Published
2021
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223. Adjuvant radiotherapy in node positive prostate cancer patients: a debate still on. when, for whom?

Author

Marvaso, Giulia, Montesano, Marianna, Corrao, Giulia, De Angelis, Simone P., Gandini, Sara, Mazzola, Giovanni C., Augugliaro, Matteo, Franzetti, Jessica, Zerini, Dario, Pepa, Matteo, Luzzago, Stefano, Mistretta, Francesco A., Musi, Gennaro, Nolè, Franco, De Cobelli, Ottavio, Orecchia, Roberto, and Jereczek‐Fossa, Barbara A.

Subjects
PROSTATE cancer patients, PROGNOSIS, RADICAL prostatectomy, ANDROGEN deprivation therapy, LYMPHADENECTOMY, CANCER relapse, CASTRATION-resistant prostate cancer
Abstract

Objective: To evaluate the impact of adjuvant radiotherapy (aRT) in patients with prostate cancer (PCa) found to have pathological positive lymph nodes (pN1s) after radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND) with regard to distant recurrence‐free survival (RFS), according to both main tumour pathological characteristics and number of positive lymph nodes. Biochemical RFS, local RFS, overall survival (OS) and acute and late toxicity were assessed as secondary endpoints. Patients and Methods: A retrospective cohort of 187 consecutive patients with pN1 PCa were treated with aRT at the IEO, European Institute of Oncology IRCCS, Milan, Italy. aRT on the tumour bed and pelvis was administered within 6 months of RP. Androgen deprivation therapy was administered according to the guidelines. Univariate and multivariate Cox regression analyses predicting biochemical RFS, local RFS, distant RFS and OS rates were performed to assess whether the number of pN1s represented an independent prognostic factor. The Youden index was computed to find the optimal threshold for the number of pN1s able to discriminate between patients with or without biochemical and clinical relapse. Results: At 5 years, local RFS, distant RFS, biochemical RFS and OS were 68%, 71%, 56% and 94%, respectively. The median follow‐up was 49 months. The number of pN1s was significantly associated with biochemical RFS, local RFS and distant RFS. The best threshold for discriminating between patients with or without biochemical and clinical relapse was five pN1s. In multivariate analyses, the number of pN1s was confirmed to be an independent predictor of biochemical RFS, local RFS and distant RFS, but not of OS. Multivariate analyses also showed an increased risk of biochemical relapse for increasing values of initial prostate‐specific antigen and for patients with tumour vascular invasion. Local and distant RFS were also inversely correlated with significantly reduced risk for International Society of Urological Pathology grade group <3 (group 1 or 2 compared to group 3). Conclusions: Our data confirmed the encouraging outcomes of patients with pN1 PCa treated with adjuvant treatments and the key role represented by the number of pN1s in predicting biochemical RFS, clinical RFS and distant RFS. Large prospective cohort studies and randomized clinical trials are needed to confirm these results and to identify the subgroup of patients with pN1 PCa who would most benefit from aRT. [ABSTRACT FROM AUTHOR]

Published
2021
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224. Outcomes of robot-assisted simple enucleation of renal masses

Author

Matei, Deliu Victor, Vartolomei, Mihai Dorin, Musi, Gennaro, Renne, Giuseppe, Tringali, Valeria Maria Lucia, Mistretta, Francesco Alessandro, Delor, Maurizio, Russo, Andrea, Cioffi, Antonio, Bianchi, Roberto, Cozzi, Gabriele, Di Trapani, Ettore, Bottero, Danilo, Cordima, Giovanni, Lucarelli, Giuseppe, Ferro, Matteo, and de Cobelli, Ottavio

Subjects
Male, renal cell carcinoma, complications, Operative Time, Observational Study, Middle Aged, Kidney, Kidney Neoplasms, robot-assisted simple enucleation, Tertiary Care Centers, Logistic Models, Postoperative Complications, Treatment Outcome, Italy, Robotic Surgical Procedures, trifecta, Multivariate Analysis, Humans, partial-nephrectomy, Female, Laparoscopy, Research Article, Retrospective Studies
Abstract

The aim of this study was to assess the ability of pre-and intraoperative parameters, to predict the risk of perioperative complications after robot-assisted laparoscopic simple enucleation (RASE) of renal masses, and to evaluate the rate of trifecta achievement of this approach stratifying the cohort according to the use of ischemia during the enucleation. From April 2009 to June 2016, 129 patients underwent RASE at our Institution. We stratified the procedures in 2 groups: clamping and clamp-less RASE. After RASE, all specimens were retrospectively reviewed to assess the surface–intermediate–base (SIB) scoring system. Patients were followed-up according to the European Association of Urology guidelines recommendations. All pre-, intra-, and postoperative outcomes were prospectively collected in a customized database and retrospectively analyzed. A total of 112 (86.8%) patients underwent a pure RASE and 17 (13.2%) had a hybrid according to SIB classification system. The mean age was 61.17 years. In 21 patients (16.3%), complications occurred, 13 (61.9%) were Clavien 1 and 2, while 8 were Clavien 3a and b complications. Statistical significant association with complications was found in patients with American Society of Anestesiology (ASA) score 3 (44.5%, P = .04), longer mean operative time (OT) 195 versus 161.36 minutes (P =.03), mean postoperative hemoglobin (Hb) 10.1 versus 11.8 (P 3, longer OT, and ΔHb. RASE is suitable for the clamp-less approach, which allows to perform easier the pure enucleation (SIB 0) and to obtain higher rates of trifecta outcomes.

Published
2017

225. Postoperative vacuum therapy following AMS™ LGX 700® inflatable penile prosthesis placement: penile dimension outcomes and overall satisfaction

Author

Antonini, Gabriele, primary, De Berardinis, Ettore, additional, Busetto, Gian Maria, additional, Del Giudice, Francesco, additional, Chung, Benjamin I., additional, Conti, Simon L., additional, Ferro, Matteo, additional, Musi, Gennaro, additional, Fragas, Ramiro, additional, De Cobelli, Ottavio, additional, Sperduti, Isabella, additional, Gross, Martin S., additional, and Perito, Paul E., additional

Published
2019
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226. Long-term oncologic and functional outcomes after robot-assisted partial nephrectomy in elderly patients

Author

Vartolomei, Mihai D., primary, Matei, Deliu V., additional, Renne, Giuseppe, additional, Tringali, Valeria M., additional, Crișan, Nicolae, additional, Musi, Gennaro, additional, Mistretta, Francesco A., additional, Russo, Andrea, additional, Conti, Andrea, additional, Cozzi, Gabriele, additional, Luzzago, Stefano, additional, Catellani, Michele, additional, Cioffi, Antonio, additional, Cordima, Giovanni, additional, Bianchi, Roberto, additional, Di Trapani, Ettore, additional, Serino, Alessandro, additional, Delor, Maurizio, additional, Bianco, Raffaele, additional, Bottero, Danilo, additional, Ferro, Matteo, additional, and De Cobelli, Ottavio, additional

Published
2019
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227. Reirradiation for isolated local recurrence of prostate cancer: Mono-institutional series of 64 patients treated with salvage stereotactic body radiotherapy (SBRT)

Author

Jereczek-Fossa, Barbara Alicja, primary, Rojas, Damaris Patricia, additional, Zerini, Dario, additional, Fodor, Cristiana, additional, Viola, Anna, additional, Fanetti, Giuseppe, additional, Volpe, Stefania, additional, Luraschi, Rosa, additional, Bazani, Alessia, additional, Rondi, Elena, additional, Cattani, Federica, additional, Vavassori, Andrea, additional, Garibaldi, Cristina, additional, Alessi, Sarah, additional, Pricolo, Paola, additional, Petralia, Giuseppe, additional, Cozzi, Gabriele, additional, De Cobelli, Ottavio, additional, Musi, Gennaro, additional, Orecchia, Roberto, additional, Marvaso, Giulia, additional, and Ciardo, Delia, additional

Published
2019
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228. Effect of Age on Cancer-specific Mortality in Patients With Urothelial Carcinoma of the Urinary Bladder: A Population-based Competing-risks Analysis Across Disease Stages.

Author

Luzzago, Stefano, Knipper, Sophie, Palumbo, Carlotta, Rosiello, Giuseppe, Pecoraro, Angela, Deuker, Marina, Mistretta, Francesco A., Tian, Zhe, Musi, Gennaro, Montanari, Emanuele, Shariat, Shahrokh F., Saad, Fred, Briganti, Alberto, de Cobelli, Ottavio, and Karakiewicz, Pierre I.

Published
2020
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229. Survival of contemporary patients with non-metastatic urachal vs. non-urachal adenocarcinoma of the urinary bladder.

Author

Luzzago, Stefano, Palumbo, Carlotta, Rosiello, Giuseppe, Pecoraro, Angela, Deuker, Marina, Mistretta, Francesco Alessandro, Tian, Zhe, Musi, Gennaro, Montanari, Emanuele, Shariat, Shahrokh F., Saad, Fred, Briganti, Alberto, de Cobelli, Ottavio, and Karakiewicz, Pierre I.

Subjects
BLADDER, ADENOCARCINOMA, REGRESSION analysis, SUBGROUP analysis (Experimental design)
Abstract

Purpose: To test the effect of tumor location (urachal vs. non-urachal) on cancer-specific mortality (CSM) in patients with adenocarcinoma of the urinary bladder (ADKUB). Materials and methods: Within the Surveillance, Epidemiology, and End Results registry (2004–2016), we identified patients with non-metastatic (≤ T4N0M0) ADKUB. Stratification was made according to tumor location: urachal vs. non-urachal ADKUB. Kaplan–Meier plots and multivariable Cox regression models were fitted before and after 1:3 propensity score (PS) matching and separate Cox regression models were refitted before and after inverse probability of treatment weighting (IPTW). Results: Of 1681 patients, 226 (13.5%) vs. 1455 (86.5%) harboured urachal vs. non-urachal ADKUB, respectively. Five-year cancer-specific survival (CSS) rates were, respectively, 75 vs. 67% for urachal vs. non-urachal ADKUB (p = 0.001). In subgroup analyses of ≤ T2N0M0 patients, 5-year CSS rates were, respectively, 84 vs. 73% for urachal vs. non-urachal ADKUB (p = 0.006). In subgroup analyses of T3-4N0M0 patients, 5-year CSS rates were, respectively, 68 vs. 49% for urachal vs. non-urachal ADKUB (p < 0.001). In multivariable Cox regression models, urachal ADKUB was associated with lower CSM rates (HR 0.6; p = 0.01). Virtually, the same findings were recorded after 1:3 PS matching (HR 0.6; p = 0.009) as well as when Cox regression models were refitted after IPTW (HR 0.7; p = 0.01). Conclusion: The distinction between urachal vs. non-urachal ADKUB indicates better prognosis when the origin of the tumor is urachal, regardless of methodological approach used for the comparison. [ABSTRACT FROM AUTHOR]

Published
2020
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232. Racial and ethnic differences in survival in contemporary metastatic renal cell carcinoma patients, according to alternative treatment modalities.

Author

Luzzago, Stefano, Palumbo, Carlotta, Rosiello, Giuseppe, Knipper, Sophie, Pecoraro, Angela, Nazzani, Sebastiano, Tian, Zhe, Musi, Gennaro, Montanari, Emanuele, Shariat, Shahrokh F., Saad, Fred, Briganti, Alberto, de Cobelli, Ottavio, and Karakiewicz, Pierre I.

Subjects
RENAL cell carcinoma, ETHNIC differences, RACIAL differences, AFRICAN Americans, CAUCASIAN race
Abstract

Purpose: To test the association between African-American race and overall mortality (OM) rates in patients with metastatic renal cell carcinoma (mRCC).Methods: Within the Surveillance, Epidemiology, and End Results registry (2006-2015), we identified patients with clear cell (ccmRCC) and non-clear cell mRCC (non-ccmRCC). African-Americans, Caucasians, and Hispanics were identified. Stratification was made according to histology and treatments: (1) no treatment, (2) systemic therapy (ST), (3) cytoreductive nephrectomy (CNT), (4) CNT + ST. Kaplan-Meier plots and multivariable Cox regression analyses were used.Results: Of ccmRCC patients, 410 (7%), 4353 (75%), and 1005 (17%) were African-American, Caucasian, and Hispanic, respectively. Of non-ccmRCC patients, 183 (25%), 479 (65%), and 77 (10%) were African-American, Caucasian, and Hispanic, respectively. In ccmRCC, African-Americans were associated with higher OM rates (HR 1.20; 95% CI 1.05-1.37). Conversely, in non-ccmRCC, African-Americans were associated with lower OM rates (HR 0.75; 95% CI 0.59-0.97).Conclusion: African-American race is associated with prolonged survival in non-ccmRCC, but it is also associated with lower survival rates in ccmRCC. The exception to these observations consisted of patients treated with combination of CNT + ST for either ccmRCC or non-ccmRCC. [ABSTRACT FROM AUTHOR]

Published
2020
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233. Conditional survival of patients with stage I–III squamous cell carcinoma of the penis: temporal changes in cancer-specific mortality.

Author

Mistretta, Francesco Alessandro, Palumbo, Carlotta, Knipper, Sophie, Mazzone, Elio, Pecoraro, Angela, Tian, Zhe, Musi, Gennaro, Perrotte, Paul, Montanari, Emanuele, Shariat, Shahrokh F., Saad, Fred, Briganti, Alberto, de Cobelli, Ottavio, and Karakiewicz, Pierre I.

Subjects
SQUAMOUS cell carcinoma, PENIS, MORTALITY
Abstract

Purpose: To test the conditional survival that examined the effect of event-free survival on cancer-specific mortality after primary tumour excision (PTE) in patients with squamous cell carcinoma of the penis (SCCP). Materials and methods: Within the SEER database (1998–2015), 2282 stage I–III SCCP patients were identified. Conditional survival estimates were used to calculate cancer-specific mortality (CSM) after event-free survival intervals of 1, 2, 3, and 5 years. Multivariable Cox regression models predicted CSM according to event-free survival. Results: After PTE, 5-year CSM-free rate was 78.0% and increased to 84.6%, 88.1%, 92.0%, and 94.2% in patients who survived ≥ 1, ≥ 2, ≥ 3, and ≥ 5 years. After stratification according to tumour characteristics, 5-year CSM-free rates increased from 85.9 to 95.4%, 79.0 to 97.1%, 78.9 to 90.0%, and from 54.5 to 86.0% in those survived ≥ 5 years, respectively, in T1N0, T2N0, T3N0, and N1-2 patients. In multivariable analyses, T2N0 [hazard ratio (HR) 1.68; p value < 0.001], T3N0 (HR 1.94; p value 0.001), and N1-2 (HR 6.61; p value < 0.001) were independent predictors of higher CSM rate at baseline, relative to T1N0. A decrease in all HRs was assessed over time in patients who survived. Attrition due to CSM was highest in N1-2 cohort and lowest in T1N0. Conclusions: Conditional survival models showed a direct relationship between event-free survival duration and subsequent CSM in SCCP patients. Even patients with non-organ-confined disease may achieve survival probabilities similar to those with organ-confined disease after at least 5 years of event-free survival since PTE. [ABSTRACT FROM AUTHOR]

Published
2020
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234. Incidence of fatigue and low-dose corticosteroid use in prostate cancer patients receiving systemic treatment: a meta-analysis of randomized controlled trials

Author

Ferro, Matteo, primary, Di Lorenzo, Giuseppe, additional, de Cobelli, Ottavio, additional, Bruzzese, Dario, additional, Pignataro, Piero, additional, Borghesi, Marco, additional, Musi, Gennaro, additional, Vartolomei, Mihai Dorin, additional, Cosimato, Vincenzo, additional, Serino, Alessandro, additional, Ieluzzi, Vincenzo, additional, Terracciano, Daniela, additional, Damiano, Rocco, additional, Cantiello, Francesco, additional, Mistretta, Francesco Alessandro, additional, Muto, Matteo, additional, Lucarelli, Giuseppe, additional, De Placido, Pietro, additional, and Buonerba, Carlo, additional

Published
2018
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235. Validation of Neutrophil-to-lymphocyte Ratio in a Multi-institutional Cohort of Patients With T1G3 Non–muscle-invasive Bladder Cancer

Author

Vartolomei, Mihai Dorin, primary, Ferro, Matteo, additional, Cantiello, Francesco, additional, Lucarelli, Giuseppe, additional, Di Stasi, Savino, additional, Hurle, Rodolfo, additional, Guazzoni, Giorgio, additional, Busetto, Gian Maria, additional, De Berardinis, Ettore, additional, Damiano, Rocco, additional, Perdona, Sisto, additional, Verze, Paolo, additional, La Rocca, Roberto, additional, Borghesi, Marco, additional, Schiavina, Riccardo, additional, Brunocilla, Eugenio, additional, Almeida, Gilberto L., additional, Bove, Pierluigi, additional, Lima, Estevao, additional, Grimaldi, Giovanni, additional, Autorino, Riccardo, additional, Crisan, Nicolae, additional, Abu Farhan, Abdal Rahman, additional, Battaglia, Michele, additional, Serretta, Vincenzo, additional, Russo, Giorgio Ivan, additional, Morgia, Giuseppe, additional, Terracciano, Daniela, additional, Musi, Gennaro, additional, de Cobelli, Ottavio, additional, Mirone, Vincenzo, additional, and Shariat, Shahrokh F., additional

Published
2018
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236. Neutrophil, Platelets, and Eosinophil to Lymphocyte Ratios Predict Gleason Score Upgrading in Low-Risk Prostate Cancer Patients

Author

Ferro, Matteo, primary, Musi, Gennaro, additional, Serino, Alessandro, additional, Cozzi, Gabriele, additional, Mistretta, Francesco Alessandro, additional, Costa, Beatrice, additional, Bianchi, Roberto, additional, Cordima, Giovanni, additional, Luzzago, Stefano, additional, Di Trapani, Ettore, additional, Tagliabue, Elena, additional, Vartolomei, Mihai Dorin, additional, Terracciano, Daniela, additional, Cassatella, Maria C., additional, Salvatici, Michela, additional, Conti, Andrea, additional, Sandri, Maria Teresa, additional, Cioffi, Antonio, additional, Turetti, Matteo, additional, Catellani, Michele, additional, Bottero, Danilo, additional, Matei, Deliu Victor, additional, Mirone, Vincenzo, additional, and de Cobelli, Ottavio, additional

Published
2018
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237. Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study

Author

Cindolo, Luca, primary, Spiess, Philippe E., additional, Bada, Maida, additional, Chipollini, Juan J., additional, Nyirády, Peter, additional, Chiodini, Paolo, additional, Varga, Judith, additional, Ditonno, Pasquale, additional, Battaglia, Michele, additional, De Nunzio, Cosimo, additional, Tema, Giorgia, additional, Veccia, Alessandro, additional, Antonelli, Alessandro, additional, Musi, Gennaro, additional, De Cobelli, Ottavio, additional, Conti, Andrea, additional, Micali, Salvatore, additional, Álvarez-Maestro, Mario, additional, Olarte, José Quesada, additional, Diogenes, Erico, additional, Lima, Marcos Venicio Alves, additional, Tracey, Andrew, additional, Guruli, Georgi, additional, Autorino, Riccardo, additional, Sountoulides, Petros, additional, and Schips, Luigi, additional

Published
2018
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238. Systemic Inflammatory Markers and Oncologic Outcomes in Patients with High-risk Non–muscle-invasive Urothelial Bladder Cancer

Author

Cantiello, Francesco, primary, Russo, Giorgio I., additional, Vartolomei, Mihai Dorin, additional, Farhan, Abdal Rahman Abu, additional, Terracciano, Daniela, additional, Musi, Gennaro, additional, Lucarelli, Giuseppe, additional, Di Stasi, Savino M., additional, Hurle, Rodolfo, additional, Serretta, Vincenzo, additional, Busetto, Gian Maria, additional, Scafuro, Chiara, additional, Perdonà, Sisto, additional, Borghesi, Marco, additional, Schiavina, Riccardo, additional, Cioffi, Antonio, additional, De Berardinis, Ettore, additional, Almeida, Gilberto L., additional, Bove, Pierluigi, additional, Lima, Estevao, additional, Ucciero, Giuseppe, additional, Matei, Deliu Victor, additional, Crisan, Nicolae, additional, Verze, Paolo, additional, Battaglia, Michele, additional, Guazzoni, Giorgio, additional, Autorino, Riccardo, additional, Morgia, Giuseppe, additional, Damiano, Rocco, additional, de Cobelli, Ottavio, additional, Mirone, Vincenzo, additional, Shariat, Shahrokh F., additional, and Ferro, Matteo, additional

Published
2018
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240. An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer

Author

Ferro, Matteo, primary, Vartolomei, Mihai Dorin, additional, Russo, Giorgio Ivan, additional, Cantiello, Francesco, additional, Farhan, Abdal Rahman Abu, additional, Terracciano, Daniela, additional, Cimmino, Amelia, additional, Di Stasi, Savino, additional, Musi, Gennaro, additional, Hurle, Rodolfo, additional, Serretta, Vincenzo, additional, Busetto, Gian Maria, additional, De Berardinis, Ettore, additional, Cioffi, Antonio, additional, Perdonà, Sisto, additional, Borghesi, Marco, additional, Schiavina, Riccardo, additional, Cozzi, Gabriele, additional, Almeida, Gilberto L., additional, Bove, Pierluigi, additional, Lima, Estevao, additional, Grimaldi, Giovanni, additional, Matei, Deliu Victor, additional, Crisan, Nicolae, additional, Muto, Matteo, additional, Verze, Paolo, additional, Battaglia, Michele, additional, Guazzoni, Giorgio, additional, Autorino, Riccardo, additional, Morgia, Giuseppe, additional, Damiano, Rocco, additional, de Cobelli, Ottavio, additional, Shariat, Shahrokh, additional, Mirone, Vincenzo, additional, and Lucarelli, Giuseppe, additional

Published
2018
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242. Thulium Laser Treatment of Upper Urinary Tract Carcinoma: A Multi-Institutional Analysis of Surgical and Oncological Outcomes

Author

Musi, Gennaro, primary, Mistretta, Francesco A., additional, Marenghi, Carlo, additional, Russo, Andrea, additional, Catellani, Michele, additional, Nazzani, Sebastiano, additional, Conti, Andrea, additional, Luzzago, Stefano, additional, Ferro, Matteo, additional, Matei, Deliu V., additional, Carmignani, Luca, additional, and de Cobelli, Ottavio, additional

Published
2018
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243. MP67-17 PERIOPERATIVE AND LONG-TERM ONCOLOGICAL OUTCOMES AFTER LOCAL TUMOR ABLATION FOR COMPLEX (PADUA SCORE ≥10) RENAL TUMORS: A MULTICENTER ANALYSIS.

Author

Piazza, Pietro, Bianchi, Lorenzo, Luzzago, Stefano, Bandini, Marco, Mottaran, Angelo, Amirhassankhani, Sasan, Puliatti, Stefano, De Concilio, Bernardino, Celia, Antonio, Serra, Carla, Cappelli, Alberta, Golfieri, Rita, Musi, Gennaro, Gallina, Andrea, Rizzo, Michele, Liguori, Giovanni, Trombetta, Carlo, Schiavina, Riccardo, De Cobelli, Ottavio, and Montorsi, Francesco

Subjects
KIDNEY tumors, NEPHRECTOMY, TUMORS, PATIENTS' attitudes, SURGICAL complications, CATHETER ablation
Published
2024
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244. PD33-05 PROPOSAL AND INTERNAL VALIDATION OF A NOMOGRAM FOR THE PREDICTION OF LOCAL RECURRENCE-FREE SURVIVAL AFTER PERCUTANEOUS ABLATION FOR cT1 RENAL MASSES.

Author

Mottaran, Angelo, Nocera, Luigi, Bianchi, Lorenzo, Luzzago, Stefano, Bandini, Marco, Piazza, Pietro, Celia, Antonio, Serra, Carla, Cappelli, Alberta, De Cinque, Antonio, Modestino, Francesco, Golfieri, Rita, Musi, Gennaro, Gallina, Andrea, De Cobelli, Francesco, Mauri, Giovanni, Orsi, Franco, Capitanio, Umberto, Schiavina, Riccardo, and Cobelli, Ottavio De

Subjects
NOMOGRAPHY (Mathematics), FORECASTING, DECISION making
Published
2024
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245. MP38-16 SURVIVAL BENEFIT OF NEPHROURETERECTOMY IN SYSTEMIC THERAPY EXPOSED METASTATIC UPPER TRACT URINARY UROTHELIAL CARCINOMA PATIENTS.

Author

Morra, Simone, Incesu, Reha-Baris, Scheipner, Lukas, Baudo, Andrea, Jannello, Letizia M. I., Siech, Carolin, De Angelis, Mario, Tian, Zhe, Creta, Massimiliano, Califano, Gianluigi, Ruvolo, Claudia Colla', Saad, Fred, Shariat, Shahrokh F., Chun, Felix, De Cobelli, Ottavio, Musi, Gennaro, Briganti, Alberto, Tilki, Derya, Ahyai, Sascha, and Carmignagni, Luca

Subjects
TRANSITIONAL cell carcinoma, URINARY organs, METASTASIS
Published
2024
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246. MP22-07 CONTEMPORARY CONDITIONAL CANCER-SPECIFIC SURVIVAL RATES IN SURGICALLY TREATED NON-METASTATIC PRIMARY URETHRAL CARCINOMA.

Author

Morra, Simone, Scheipner, Lukas, Baudo, Andrea, Jannello, Letizia M. I., Angelis, Mario De, Siech, Carolin, Goyal, Jordan A., Touma, Nawar, Tian, Zhe, Saad, Fred, Shariat, Sharhokh, Creta, Massimiliano, Califano, Gianluigi, Celentano, Giuseppe, Ruvolo, Claudia Colla', Ahyai, Sascha, Carmignani, Luca, Cobelli, Ottavio De, Musi, Gennaro, and Briganti, Alberto

Subjects
SURVIVAL rate, URETHRAL cancer, EXPOSURE therapy, CARCINOMA
Published
2024
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247. PD11-10 THE IMPACT OF HISTOLOGY AND TYPE OF ENERGY USED ON ONCOLOGICAL OUTCOMES AFTER LOCAL TUMOR ABLATION OF SMALL RENAL MASSES.

Author

Piazza, Pietro, Bianchi, Lorenzo, Luzzago, Stefano, Bandini, Marco, Mottaran, Angelo, Amirhassankhani, Sasan, De Concilio, Bernardino, Celia, Antonio, Puliatti, Stefano, Scarlatti, Riccardo, Serra, Carla, Cappelli, Alberta, Golfieri, Rita, Musi, Gennaro, Gallina, Andrea, Schiavina, Riccardo, De Cobelli, Ottavio, Montorsi, Francesco, and Brunocilla, Eugenio

Subjects
ENERGY consumption, HISTOLOGY, NEPHRECTOMY, HISTOLOGICAL techniques
Published
2024
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248. MRI-targeted or systematic random biopsies for prostate cancer diagnosis in biopsy naïve patients: follow-up of a PRECISION trial-like retrospective cohort

Author

Luzzago, Stefano, de Cobelli, Ottavio, Mistretta, Francesco A., Piccinelli, Mattia Luca, Lorusso, Vito, Morelli, Michele, Bianchi, Roberto, Catellani, Michele, Cozzi, Gabriele, Di Trapani, Ettore, Pricolo, Paola, Alessi, Sarah, Ferro, Matteo, Marvaso, Giulia, Matei, Deliu-Victor, Jereczek-Fossa, Barbara Alicja, Petralia, Giuseppe, and Musi, Gennaro

Abstract

Background: To test clinically significant prostate cancer (csPCa) rates during follow-up in biopsy naïve patients that underwent two different diagnostic pathways: (1) SB GROUP (n= 354): systematic random biopsies (SB) vs. (2) TB GROUP (n= 264): multiparametric magnetic resonance imaging (mpMRI) and only targeted biopsies (TB) of PI-RADS ≥ 3 lesions. Patients with PI-RADS ≤ 2 score avoided prostate biopsies. Methods: Retrospective single centre study of 618 biopsy naive patients (2015–2018). Two different definitions of csPCa were used: (1) csPCa ISUP GG ≥ 2 (ISUP grade group [GG] ≥ 2) and (2) csPCa ISUP GG ≥ 3. Kaplan–Meier plots and univariable Cox regression models tested rates over time of csPCa ISUP GG ≥ 2 and caPCa ISUP GG ≥ 3 in SB GROUP vs. TB GROUP. Results: At initial biopsy, TB achieved higher rates of csPCa ISUP GG ≥ 2 (35.3 vs. 18.9%; p&lt; 0.001) and csPCa ISUP GG ≥ 3 (12.6 vs. 6.2%; p= 0.04), relative to SB. After a median time follow-up of 36 months, the rates of csPCa ISUP GG ≥ 2 (6.1 vs. 4.4%; p= 0.6) and csPCa ISUP GG ≥ 3 (3.3 vs. 1.1%; p= 0.2) were similar in SB GROUP vs. TB GROUP. Moreover, in TB GROUP patients that avoided prostate biopsies because of negative baseline mpMRI (n= 145), only 4.1% exhibited csPCa ISUP GG ≥ 2 during follow-up. Moreover, none of these patients (PI-RADS ≤ 2) had csPCa ISUP GG ≥ 3. Conclusions: In biopsy naïve setting, a diagnostic pathway including pre-biopsy mpMRI and TB of only PCa suspicious lesions is not associated with higher rates of csPCa during follow-up, relative to a diagnostic pathway of SB. Moreover, patients with negative baseline mpMRI could safely avoid prostate biopsies and could be followed with repeated PSA testing, since only a small proportion of them would harbor csPCa.

Published
2021
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249. Contemporary rates and predictors of open conversion during minimally invasive partial nephrectomy for kidney cancer

Author

Luzzago, Stefano, Rosiello, Giuseppe, Pecoraro, Angela, Deuker, Marina, Stolzenbach, Franziska, Mistretta, Francesco Alessandro, Tian, Zhe, Musi, Gennaro, Montanari, Emanuele, Shariat, Shahrokh F., Saad, Fred, Briganti, Alberto, de Cobelli, Ottavio, and Karakiewicz, Pierre I.

Abstract

To test contemporary rates and predictors of open conversion at minimally invasive partial nephrectomy (MIPN: laparoscopic or robotic partial nephrectomy).

Published
2021
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250. Multiparametric Magnetic-Resonance to Confirm Eligibility to an Active Surveillance Program for Low-Risk Prostate Cancer: Intermediate Time Results of a Third Referral High Volume Centre Active Surveillance Protocol

Author

Luzzago, Stefano, primary, Musi, Gennaro, additional, Catellani, Michele, additional, Russo, Andrea, additional, Di Trapani, Ettore, additional, Mistretta, Francesco Alessandro, additional, Bianchi, Roberto, additional, Cozzi, Gabriele, additional, Conti, Andrea, additional, Pricolo, Paola, additional, Ferro, Matteo, additional, Matei, Deliu-Victor, additional, Mirone, Vincenzo, additional, Petralia, Giuseppe, additional, and de Cobelli, Ottavio, additional

Published
2018
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