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781 results on '"Myers, Leann"'

204. Statistical Characterization of Multibeam Bathymetry Data

Author

NAVAL RESEARCH LAB STENNIS SPACE CENTER MS MARINE GEOSCIENCES DIV, Morgan, Leslie, Martinez, Andrew, Myers, Leann, Bourgeois, Brian, NAVAL RESEARCH LAB STENNIS SPACE CENTER MS MARINE GEOSCIENCES DIV, Morgan, Leslie, Martinez, Andrew, Myers, Leann, and Bourgeois, Brian

Abstract

Multibeam sonar systems produce high-density depth data of the ocean floor. Point pattern analysis of the individual depth points is conducted to determine an appropriate parameterized point-to-event distance distribution, F(y). This distribution is needed to quantify the lower bound on the estimated position error of a terrain-based navigation system being developed. The null hypothesis assumes that a Poisson point process produced the two-dimensional pattern. Under the null, F(y) has been shown to follow an exponential distribution where y is the distance from any arbitrary point in the study area to the nearest point in the pattern. Several tests of the null hypothesis are conducted. These tests lead to a rejection of the null in favor of a regular alternative. Probability plots and likelihood ratio tests are used to suggest an appropriate distribution, F(y), for the regular point pattern. These tests suggest that a two parameter Weibull distribution with increasing hazard rate may be an appropriate model. Monte Carlo simulations are conducted to determine goodness-of-fit of the Weibull model., Original contains color plates: All DTIC reproductions will be in black and white.

Published
2001

212. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

Author

Kryczek, Ilona, primary, Zou, Linhua, additional, Rodriguez, Paulo, additional, Zhu, Gefeng, additional, Wei, Shuang, additional, Mottram, Peter, additional, Brumlik, Michael, additional, Cheng, Pui, additional, Curiel, Tyler, additional, Myers, Leann, additional, Lackner, Andrew, additional, Alvarez, Xavier, additional, Ochoa, Augusto, additional, Chen, Lieping, additional, and Zou, Weiping, additional

Published
2006
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217. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Author

Curiel, Tyler J, primary, Coukos, George, additional, Zou, Linhua, additional, Alvarez, Xavier, additional, Cheng, Pui, additional, Mottram, Peter, additional, Evdemon-Hogan, Melina, additional, Conejo-Garcia, Jose R, additional, Zhang, Lin, additional, Burow, Matthew, additional, Zhu, Yun, additional, Wei, Shuang, additional, Kryczek, Ilona, additional, Daniel, Ben, additional, Gordon, Alan, additional, Myers, Leann, additional, Lackner, Andrew, additional, Disis, Mary L, additional, Knutson, Keith L, additional, Chen, Lieping, additional, and Zou, Weiping, additional

Published
2004
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234. Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

Author

Curiel, Tyler J., primary, Wei, Shuang, additional, Dong, Haidong, additional, Alvarez, Xavier, additional, Cheng, Pui, additional, Mottram, Peter, additional, Krzysiek, Roman, additional, Knutson, Keith L., additional, Daniel, Ben, additional, Zimmermann, Maria Carla, additional, David, Odile, additional, Burow, Matthew, additional, Gordon, Alan, additional, Dhurandhar, Nina, additional, Myers, Leann, additional, Berggren, Ruth, additional, Hemminki, Akseli, additional, Alvarez, Ronald D., additional, Emilie, Dominique, additional, Curiel, David T., additional, Chen, Lieping, additional, and Zou, Weiping, additional

Published
2003
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235. Partner Notification for HIV and Syphilis

Author

KISSINGER, PATRICIA J., primary, NICCOLAI, LINDA M., additional, MAGNUS, MANYA, additional, FARLEY, THOMAS A., additional, MAHER, JULIE E., additional, RICHARDSON-ALSTON, GWANGI, additional, DORST, DENNIS, additional, MYERS, LEANN, additional, and PETERMAN, THOMAS A., additional

Published
2003
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236. Distribution and correlates of non-high-density lipoprotein cholesterol in children: the Bogalusa Heart Study

Author

Srinivasan, Sathanur R., Myers, Leann, and Berenson, Gerald S.

Subjects
Cholesterol -- Measurement, Coronary heart disease -- Risk factors
Abstract

Objective. Serum non-high-density lipoprotein (HDL) cholesterol (total cholesterol minus HDL cholesterol) is considered a better screening tool than low-density lipoprotein (LDL) cholesterol for the assessment of coronary artery disease (CAD) risk in adults because it includes all classes of atherogenic lipoproteins. Although population frequency distribution and clinically useful cutpoints for this variable in adults have been reported recently, such information is lacking in children. Therefore, this study sought to provide population-based data on the distribution and correlates of non-HDL cholesterol in biracial (black-white) children. Methods. The study sample consisted of 2843 5- to 17-year-olds (57% white, 50% female) who participated in a cross-sectional screening of cardiovascular risk factors as part of the Bogalusa Heart Study. Results. Non-HDL cholesterol levels were similar in black and white children, and higher in girls than in boys, especially among the younger (5-11 years) age group. Age was inversely related to both non-HDL cholesterol and LDL cholesterol. Body fatness as measured by body mass index and waist circumference was positively associated with non-HDL cholesterol. The magnitude of correlation with triglycerides was relatively higher for non-HDL cholesterol versus LDL cholesterol. Non-HDL cholesterol showed an inverse relation to HDL cholesterol. In a multivariate analysis, body mass index, age, gender, waist circumference, and cigarette smoking accounted for 7.7% of the variance in non-HDL cholesterol. Non-HDL cholesterol levels equivalent to currently recommended LDL cutpoints (110, 130, 160, and 190 mg/ dL) for CAD risk assessment were 123, 144, 176, and 207 mg/dL. Conclusion. Population-based data on non-HDL cholesterol are now available for children, which may help improve the CAD risk assessment and intervention. Pediatrics 2002;110(3). URL: http://www.pediatrics.org/ cgi/content/full/110/3/e29; non-HDL cholesterol, LDL cholesterol, children, coronary artery disease.

Published
2002

248. Response

Author

Myers, Leann, primary and Broyles, Stephanie T., additional

Published
2001
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250. Kinetics of Genetic Variation of the Mycoplasma genitaliumMG192 Gene in Experimentally Infected Chimpanzees

Author

Ma, Liang, Jensen, Jørgen S., Mancuso, Miriam, Myers, Leann, and Martin, David H.

Abstract

ABSTRACTMycoplasma genitalium, a human pathogen associated with sexually transmitted diseases, is capable of causing chronic infections, though mechanisms for persistence remain unclear. Previous studies have found that variation of the MgPa operon occurs by recombination of repetitive chromosomal sequences (known as MgPars) into the MG191 and MG192 genes carried on this operon, which may lead to antigenic variation and immune evasion. In this study, we determined the kinetics of MG192 sequence variation during the course of experimental infection using archived specimens from two chimpanzees infected with M. genitaliumstrain G37. The highly variable region of MG192 was amplified by PCR from M. genitaliumisolates obtained at various time points postinfection (p.i.). Sequence analysis revealed that MG192 sequence variation began at 5 weeks p.i. With the progression of infection, sequence changes accumulated throughout the MG192 variable region. The presence of MG192 variants at specific time points was confirmed by variant-specific PCR assays and sequence analysis of single-colony cloned M. genitaliumorganisms. MG192 nucleotide sequence variation correlated with estimated recombination events, predicted amino acid changes, and time of seroconversion, a finding consistent with immune selection of MG192 variants. In addition, we provided evidence that MG192 sequence variation occurred during the process of M. genitaliumsingle-colony cloning. Such spontaneous variation suggests that some MG192 variation is independent of immune selection but may form the basis for subsequent immune selection.

Published
2016
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