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The south of the Russian Far East is distinguished by diversity of natural conditions for the presence of vectors and circulation of pathogens, primarily tick-borne infections. Despite the relatively low proportion of tick-borne encephalitis in the structure of tick-borne infections and the rather low incidence rate compared to other Russian regions, the disease here has epidemiological significance, which is associated with its severe course. Therefore, it is important to identify local areas of greatest epidemic manifestation of the disease and potential drivers influencing the spread of tick-borne encephalitis. This study uses data on population incidence in the municipal districts of Khabarovsk Krai, Amur Oblast, Jewish Autonomous Oblast and Zabaikalsky Krai between 2000 and 2020. Based on Kulldorf spatial scanning statistics, a temporally stable cluster of virus circulation in the population in the southwest of Zabaikalsky Krai was identified, which existed during 2009-2018. Regression modeling using zero-inflated negative binomial regression based on a set of environmental and socio-economic predictors allowed to identify variables determining the probability of infection: the share of forest, the amount of precipitation in the warm period, population density, as well as variables reflecting population employment and socio-economic well-being. Despite the fact that tick-borne encephalitis is a natural focal disease and may be characterized by natural periods of increased incidence, the influence of the social component can have a strong impact on the epidemiological manifestation. The identified spatio-temporal differences within the study region and potential drivers must be taken into account when developing a set of preventive measures.

Introduction. The reasons for the reduction of durability of flexural structures due to the violation of the protective layer of reinforcement are considered. It breaks down when cracks form. Cracks can self-heal by various methods, the most effective of which is microbial-induced precipitation of calcium carbonate.Materials and methods. Bacillus subtilis strains VKM B-70 and VKM B-501 (All-Russian Collection of Microorganisms), microsilica, metakaolin, and fly ash were used. Bacterial activity was assessed by culturing bacterial strains from tablet specimens. The pH of the specimens was determined using the pH meter. The crack growth rate was assessed by visual inspection of the tablet specimens by the optical microscope.Results. The results of the experiment on selection of optimal size of alginate bacterial granules for biomineral additives are shown. The effect of biomineral additives of various compositions on the overgrowth of cracks with a width of 100 to 500 µm was studied. The effect of increasing bacterial activity in the presence of the pozzolanic component is shown. The relationship between the alkalinity of the specimen medium and bacterial activity was revealed.Conclusions. The recommended granule diameter is 1–1.8 mm. The bacterial activity in such granules increases in the presence of pozzolanic component in the composition of the additive. Fly ash was most effective in formulations with Bacillus subtilus bacteria due to its ability to lower the pH of cement-sand compositions. By lowering the pH, conditions that are more favourable are created for the vital activity of bacteria. When using complex biomineral additives, there is a significant increase in the rate of crack healing, which will allow self-healing of cracks with a width of 100 microns in just five water-air cycles.

This work presents the results of studying the evaluation of fMRI data at the group level. Some factors influencing the formation of such estimates are shown. On the basis of experimental data obtained in forensic tests in the information concealment paradigm, attention is drawn to the need for a critical assessment of the results and methodology (design) of research, based on the results of which the outcome of the analysis of fMRI data at the group level are presented.

One of the factors in the development of uterine fibroids is a genetic predisposition to its occurrence in some women, but the real molecular genetic mechanisms of this phenomenon remain unknown. Aim of the study was the distribution analysis of gene polymorphism of cytokines TNFα, IL-1β, IL-4, IL-6, IL-10, factors of angiogenesis (vascular endothelial growth factor, VEGF) and remodeling of extracellular matrix (metalloproteinases MMP2, MMP3, MMP9), which are associated with their levels. Material and methods. Genotyping was performed by real-time PCR using commercial test systems SYBR GreenI (Litech, Russia) and TaqMan (Syntol, Russia) in accordance with the instructions of the developer. Cytokine content in blood serum was determined by flow cytometry using microspheres coated with monoclonal antibodies to cytokines (Bio-Plex ProTM Human Cytokine 27-plex Assay), according to the instructions for Bio-Plex 200 (Bio-Rad Laboratories, USA).To evaluate the results obtained, in addition to the generally accepted methods of statistical processing for case – control studies, computational methods of bioinformatics were used for comparative analysis of the diagnostic value of various combined genetic traits. Results. It was shown that the maximum odds ratio value of uterine fibroids development are combined genetic traits that include representatives of all four regulatory factors: cytokines with pro-inflammatory activity, cytokines with anti-inflammatory activity, vascular endothelial growth factors and metalloproteinases (p = 0.002). Conclusions. The presented data reveal the real mechanisms of manifestation of the genetic predisposition of individual women to the uterine fibroids development, associated with the presence of polymorphism of certain genes in their genome, which provide features of the structure of cytokine networks with the predominance of certain activities in the regulation of tissue processes in the uterus. In addition to purely scientific interest, these results indicate the real possibility of their clinical application in the form of prognostic criteria with a certain level of prognostic significance.

We describe a new treefrog species from Lao Cai Province, northwestern Vietnam. The new species is assigned to the genus Zhangixalus based on a combination of the following morphological characters: (1) dorsum green, smooth; body size medium (SVL 30.1–32.2 in males); (2) fingers webbed; tips of digits expanded into large disks, bearing circum-marginal grooves; (3) absence of dermal folds along limbs; (4) absence of supracloacal fold and tarsal projection. The new species can be distinguished from its congeners by: (1) dorsal surface of the head and body green without spots; (2) axilla and groin cream with a black blotch; (3) ventral cream without spot; (4) chin creamy with grey marbling; anterior part of the thigh and ventral surface of tibia orange without spots; posterior parts of thigh orange with a large black blotch; (5) ventral side of webbing orange with some grey pattern (6) iris red-bronze, pupils black; (7) finger webbing formula I1¼-1¼II1-2III1-1IV, toe webbing formula I½-½II0-1½III¼-1¾IV1¾-½V. Phylogenetically, the new species is nested in the same subclade as Z. jodiae, Z. pinglongensis, and Z. yaoshanensis, with genetic distances ranging from 3.23% to 4.68%. The new species can be found in evergreen montane tropical forests at an elevation of about 1,883 m a.s.l. This new discovery brings the number of known genus Zhangixalus species to 42 and the number of species reported from Vietnam to 10.

Over the past decade magnetic resonance imaging is being increasingly used in revealing pathological changes in peripheral nervous system due to a number of technical innovations and growth of diagnostical strength, and, therefore, due to initiation of research of several magnetic resonance imaging methods which allow to perform quantitative assessment of peripheral nerves. Among them, diffusion tensor magnetic resonance imaging which gives an opportunity to investigate microstructural changes in nerves tissue by water diffusion evaluation should be mentioned first. T2‑relaxometry and magnetization transfer ratio studies allow assessing macromolecular integrity of peripheral nerves elements. Chemical shift‑based fat fraction evaluation in peripheral nerves and corresponding muscles is also of great scientific interest both for diagnostic and therapy effect monitoring purposes. Manuscript presents brief description of above‑ mentioned methods, as well as recent results and perspectives of their application for peripheral nerves evaluation, supplemented with own illustrations of experimental observations.

The significance of this research topic is due to the relevance of the problems of modern state-building in the public and political life of North and West Africa. The purpose of the research project is to analyze the causes and consequences of the emergence of radical movements of political Islam in the Maghreb and Sahel at the junction of the XX and XXI centuries and their connection with the shortcomings of national statehood inherent in both African regions. At the same time, the author focuses on the incompleteness of the state-building process, the weakness of institutions and the low level of justification for drawing state borders as concrete examples of such shortcomings that affected the socio-political climate in the Islamized areas adjacent to the Sahara. Based on the materials of sources and the theoretical model of regional security complexes (RSC), the author identified contradictions and diversity in the ideological and value views of the North African ruling circles, analyzed the methodological and spiritual and political foundations of the deeply rooted relationship between criminal and Islamist groups on the example of the activities of Al-Qaeda in the Islamic Maghreb (AQIM) (аn organization included in the list of terrorist organizations in theRussian Federation is mentioned) and its leaders - Abd al-Malik Drukdel, Mukhtar Belmukhtar, etc. It is proved that “Islamist internationalism” in the Maghreb and Sahel of the 2000s began to take ethnocultural forms, which was caused by the ‘network’ and ‘umbrell’a nature of the AQIM (аn organization included in the list of terrorist organizations in theRussian Federation is mentioned) structure, in which there was no centralized administrative-territorial management scheme. In addition, the distinctive features of the security policy of modern Algeria are shown and the importance of studying interregional contradictions for characterizing the geopolitical and economic reasons for the strengthening of Islamic radicalism in Africa is revealed.

Introduction. The article is devoted to the analysis of the relationship between the state and ethnic group, state and ethnic identity. It reveals the mechanisms of state formation based on the development of cultural baggage created within the framework of the ethnic communicative space. Theoretical analysis. One of the distinctive features of modern states is the complex nature of the identities that comprise their citizens. The article shows in what ways and due to what the president of the state asserts the beginning of the state. On the one hand, the state is trying to bring in the best examples of ethnic culture. On the other hand, it seeks to use the possibilities of new types of identity in its manifestations (digital identity). Materials borrowed from other types of identity are improved and adapted to the situation of their use in the process of development. They tend to be integrated into modern mass culture. In the process of development of the state, there is a change in the balance of “I” and “We” identities towards strengthening individual identity. The state is trying to counter this. Conclusion. The state uses ethnic communicative space and ethnic identity as a source of borrowing valuable plots, historical characters, and holidays. It also seeks to attract to its side ethnic activists who are the carriers of this information.

Одним из основных подходов к обработке, анализу и визуализации геофизических данных является применение геоинформационных систем и технологий, что обусловлено их геопространственной привязкой. Вместе с тем, сложность представления геофизических данных связана с их комплексной структурой, предполагающей множество составляющих, которые имеют одну и ту же геопространственную привязку. Яркими примерами данных такой структуры и формата являются гравитационные и геомагнитные поля, которые в общем случае задаются трех и четырехкомпонентными векторами с разнонаправленными осями координат. При этом на сегодняшний день отсутствуют решения, позволяющие визуализировать указанные данные в комплексе, не декомпозируя их на отдельные скалярные значения, которые, в свою очередь, могут быть представлены в виде одного или многих пространственных слоев. В этой связи в работе предложена концепция, использующая элементы тензорного исчисления для обработки, хранения и визуализации информации такого формата. Формализован механизм тензорного представления компонент поля с возможностью его комбинирования с другими данными такого же формата, с одной стороны, и свертки при сочетании с данными более низкого ранга. На примере гибридной реляционно-иерархической модели данных предложен механизм хранения информации по тензорным полям, предусматривающий возможность описания и применения инструкций по трансформации при переходе между различными системами координат. В работе рассматривается применение подхода при переходе от декартовой к сферической системе координат при представлении параметров геомагнитного поля. Для комплексной визуализации параметров тензорного поля предложен подход, основанный на применении тензорных глифов. В качестве последних при этом используются суперэллипсы с осями, соответствующими рангу тензора. При этом атрибутивные значения предлагается визуализировать относительно осей графического примитива таким образом, что распределение данных может быть задано посредством варьирования градиента монохромного представления параметра вдоль оси. Работоспособность концепции была исследована в ходе сравнительного анализа тензорного подхода с решениями, основанными на скалярной декомпозиции соответствующих комплексных значений с последующим их представлением в виде одного или многих пространственных слоев. Проведенный анализ показал, что применение предложенного подхода позволит в значительной степени повысить наглядность формируемого геопространственного изображения без необходимости сложного перекрывания пространственных слоев.

The capacitance-resistance model (CRM) has been a useful physics-based tool for obtaining production forecasts for decades. However, the model's limitations make it difficult to work with real field cases, where a lot of various events happen. Such events often include new well commissioning (NWC). We introduce a workflow that combines CRM concepts and kriging into a single tool to handle these types of events during history matching. Moreover, it can be used for selecting a new well placement during infill drilling. To make the workflow even more versatile, an improved version of CRM was used. It takes into account wells shut-ins and performed workovers by additional adjustment of the model coefficients. By preliminary re-weighing and interpolating these coefficients using kriging, the coefficients for potential wells can be determined. The approach was validated using both synthetic and real datasets, from which the cases of putting new wells into operation were selected. The workflow allows a fast assessment of future well performance with a minimal set of reservoir data. This way, a lot of well placement scenarios can be considered, and the best ones could be chosen for more detailed studies.

The article is devoted to the problem of improving interaction in B2B markets. By analyzing the literature on the issues under study, the authors have identified a trend in the customer management development in B2B markets towards a unique experience creation along the entire path of interaction between an account and a company. This is a business marketing strategy aimed at understanding, engaging and providing customized services and content to target accounts. The strategy involves using marketing techniques to engage the entire organization by targeting multiple stakeholders within a single potential account. The use of CJM as a methodology currently used in B2C markets has been justified and recommendations for its application in B2B made. CJM allows companies to align their business processes and resources with the needs of accounts, ensuring smooth teamwork. Engagement tools used in account engagement management have been systematized, helping to effectively shape the account experience; engagement performance metrics have been identified. The engagement tools implementation provides the cross-functional integration needed to engage with larger accounts, aligning marketing with sales and service. The article focuses on personalizing engagement with decision makers. The research analysis also revealed the features and trends of content customization within the ABM programs.

Objective – to investigate the clinical and morphological characteristics of the manifestations of the rupture of arterial aneurysms of the brain in patients with occlusive-stenotic lesions of the cerebral arteries. Materials and methods. 1147 case histories of patients with aneurysmal disease of the cerebral arteries who underwent comprehensive examination and treatment in the Department of Neurosurgical Pathology of Head and Neck Vessels with X-ray Surgical Department «Romodanov Institute of Neurosurgery NAMS of Ukraine» since 2006 until 2022. The medical histories of 126 patients who were included in this study and divided into two groups were studied in detail. The criteria for inclusion in the main group (38 men and 25 women) were: surgical treatment; rupture of arterial aneurysm the presence (proven using instrumental examination methods) of occlusive-stenotic lesions.The criteria for inclusion in the control group (38 men and 25 women) were: surgical treatment; rupture of arterial aneurysm; absence (proven by means of instrumental examination methods) of occlusive-stenotic lesions; the gender and age distribution had to match the main group.Among the patients included in this study, there were 76 men (60.32 %) and 50 women (39.68 %). The age of the patients varied from 31 to 77 years. The average age of patients ‒ 55.9 ± 0.76 years. Results. The Hunt‒Hess severity of patients was approximately the same between the main and control groups. When evaluated by the World Federation of Neurologican Surgeons (WFNS) and Glasgow Coma scale (GCS), more patients in the control group had a lighter score. Aneurysms of the anterior cerebral-anterior connecting artery complex prevailed in both groups. A higher frequency of arterial aneurysms of the middle cerebral artery was revealed among patients of the main group (main group ‒ 27.0 %, comparison group 15.8 %). The higher number of multiple aneurysms in the main group (the main group ‒ 25.4 %, the controlgroup ‒ 12.7 %) and the smaller number of miliary aneurysms and the larger number of large aneurysms in the main group may indicate the predominance of congenital etiological factors common to both pathologies in the development of the disease until the rupture of the arterial aneurysm. Conclusions. Gender differences were established with a predominance of men among patients of the main group (60.32 %). The average age of men with occlusive-stenotic lesions was lower than that of women (men – 54.3±0.94 years, women – 58.3±1.19 years). The difference in age is especially pronounced in the subgroup of the main group where the severity of stenosis is 50‒75 % (men ‒ 48.3 years; women ‒ 62.0 years).The neurological status of patients with a hemorrhagic stroke, as a result of the rupture of an arterial aneurysm, is significantly aggravated by occlusive-stenotic lesions due to the occurrence of chronic brain ischemia. The worst prognosis is in men with a ruptured arterial aneurysm and a 50‒75 % stenotic lesion.

SCIENTIFIC RELEVANCE. Russia is pursuing a consistent government policy of import substitution and increasing the localisation of pharmaceutical manufacturing. The Strategy for the Development of the Pharmaceutical Industry until 2030 (Pharma-2030) includes the target share of medicinal products from the List of Strategic Medicines that should be fully localised. Since biotechnological medicinal products have high consumption growth rates and are listed as strategic medicines, it is a priority to study their production localisation process.AIM. This study aimed to analyse the degree of biopharmaceutical manufacturing localisation in Russia, considering the country of origin of active pharmaceutical ingredients (APIs).MATERIALS AND METHODS. The study used the State Register of Medicines and sales data of the DSM Group marketing agency. The authors used custom software for the Node.js® platform to determine the degree of production localisation.RESULTS. The analysis showed that the production process was fully localised for 25.6% (in packages) and 26.6% (in roubles) of all biotechnological medicinal products consumed in Russia in 2022. Imported medicinal products dominated the consumption structure, with a share of 33.9% in packages and 31.3% in roubles. Medicinal products with localised secondary packaging accounted for 5.8% in packages and 25.9% in roubles. Finished dosage forms produced using imported APIs had a significant share of 23.7% in packages and 6.2% in roubles. Russian APIs were used to produce 79% of the biotechnological medicinal products listed as strategic medicines, which corresponded to the full localisation of a share of the consumption structure of 10.8% in packages and 32.3% in roubles.CONCLUSIONS. The Russian biotechnological market remains heavily dependent on imported finished medicinal products and APIs. Although the Pharma-2030 target for the production of strategic biotechnological products has been achieved, the quantitative indicators show the necessity to increase output and localisation.

In Europe, Wolffia globosa was first recorded in 2002 in the RF, and not in Bulgaria, as it was previously believed. Over the past 20 years, the species has expanded its secondary range. As of 2023, it is known from seven European countries. In Ukraine, W. globosa was first found in 2023 in two localities in Zhytomyr Region (Zhytomyr Polissia). The plant communities with W. globosa in Ukraine belong to the association Lemno-Spirodeletum polyrhizae of the alliance Lemnion minoris of the class Lemnetea. In the reported localities W. globosa occurs in eutrophic stagnant waterbodies with depths of 0.2–0.5 m and weakly flowing waterbodies with depths of 1.2–1.5 m; silty bottom is covered by a silt layer 5–20 cm thick, lighting is full. It is suggested that due to the observed climate warming, further migrations of W. globosa to other regions of Ukraine are possible.