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2,266 results on '"Ozaki, N."'

208. GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder

Author

Kishi, T., Ichinose, Hiroshi, Yoshimura, R., Fukuo, Y., Kitajima, T., Inada, T., Kunugi, H., Kato, T., Yoshikawa, T., Ujike, H., Musso, G.M., Umene-Nakano, W., Nakamura, J., Ozaki, N., and Iwata, N.

Subjects
Oncology, Adult, Male, Candidate gene, medicine.medical_specialty, Bipolar Disorder, Genotype, behavioral disciplines and activities, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Internal medicine, mental disorders, Genetic model, medicine, Humans, Bipolar disorder, GTP Cyclohydrolase, Allele frequency, Genetics, Depressive Disorder, Major, Case-control study, Hamilton Rating Scale for Depression, Middle Aged, medicine.disease, Antidepressive Agents, Psychiatry and Mental health, Clinical Psychology, Logistic Models, Phenotype, Mood disorders, Haplotypes, Fluvoxamine, Case-Control Studies, Major depressive disorder, Female, Psychology, Selective Serotonin Reuptake Inhibitors
Abstract

Background Tetrahydrobiopterin (BH4) plays an important role in the biosynthesis of serotonin, melatonin and catecholamines, all of which are implicated in the pathophysiology of mood disorders (MDs), including major depressive disorder (MDD) and bipolar disorder (BP). Production of BH4 is regulated by GTP cyclohydrolase transcription and activity. Thus, we considered the GTP cyclohydrolase gene ( GCH1 ) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). Method A multiple logistic regression analysis was carried out to compare the frequencies of each SNP genotype for the target phenotype across patients and controls in several genetic models, while adjusting for possible confounding factors. A clinical response was defined as a decrease of more than 50% from the baseline score on the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D) within 8 weeks, and clinical remission as a SIGH-D score of less than 7 at 8 weeks. Result No associations between three SNPs in GCH1 and MDD or BP were observed; however, GCH1 was associated with SSRI therapeutic response in MDD in all the marker’s haplotype analysis (Global P value=0.0379). Conclusions Results suggest that GCH1 may predict response to SSRI in MDD in the Japanese population. Nevertheless, a replication study using larger samples may be required for conclusive results, since our sample size was small.

Published
2012

211. X-ray absorption spectroscopy of iron at multimegabar pressures in laser shock experiments

Author

Harmand, M., primary, Ravasio, A., additional, Mazevet, S., additional, Bouchet, J., additional, Denoeud, A., additional, Dorchies, F., additional, Feng, Y., additional, Fourment, C., additional, Galtier, E., additional, Gaudin, J., additional, Guyot, F., additional, Kodama, R., additional, Koenig, M., additional, Lee, H. J., additional, Miyanishi, K., additional, Morard, G., additional, Musella, R., additional, Nagler, B., additional, Nakatsutsumi, M., additional, Ozaki, N., additional, Recoules, V., additional, Toleikis, S., additional, Vinci, T., additional, Zastrau, U., additional, Zhu, D., additional, and Benuzzi-Mounaix, A., additional

Published
2015
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213. Postoperative Psychiatric Complications in Living Liver Donors

Author

Kimura, H., primary, Onishi, Y., additional, Sunada, S., additional, Kishi, S., additional, Suzuki, N., additional, Tsuboi, C., additional, Yamaguchi, N., additional, Imai, H., additional, Kamei, H., additional, Fujisiro, H., additional, Okada, T., additional, Ishigami, M., additional, Ogura, Y., additional, Kiuchi, T., additional, and Ozaki, N., additional

Published
2015
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214. The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study

Author

Uno, K., primary, Nishizawa, D., additional, Seo, S., additional, Takayama, K., additional, Matsumura, S., additional, Sakai, N., additional, Ohi, K., additional, Nabeshima, T., additional, Hashimoto, R., additional, Ozaki, N., additional, Hasegawa, J., additional, Sato, N., additional, Tanioka, F., additional, Sugimura, H., additional, Fukuda, K.-I.-, additional, Higuchi, S., additional, Ujike, H., additional, Inada, T., additional, Iwata, N., additional, Sora, I., additional, Iyo, M., additional, Kondo, N., additional, Won, M.-J., additional, Naruse, N., additional, Uehara-Aoyama, K., additional, Itokawa, M., additional, Yamada, M., additional, Ikeda, K., additional, Miyamoto, Y., additional, and Nitta, A., additional

Published
2015
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216. Probing iron at Super-Earth core conditions

Author

Amadou, N., primary, Brambrink, E., additional, Vinci, T., additional, Benuzzi-Mounaix, A., additional, Huser, G., additional, Brygoo, S., additional, Morard, G., additional, Guyot, F., additional, de Resseguier, T., additional, Mazevet, S., additional, Miyanishi, K., additional, Ozaki, N., additional, Kodama, R., additional, Henry, O., additional, Raffestin, D., additional, Boehly, T., additional, and Koenig, M., additional

Published
2015
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219. Common variants at 1p36 are associated with superior frontal gyrus volume

Author

Hashimoto, R, primary, Ikeda, M, additional, Yamashita, F, additional, Ohi, K, additional, Yamamori, H, additional, Yasuda, Y, additional, Fujimoto, M, additional, Fukunaga, M, additional, Nemoto, K, additional, Takahashi, T, additional, Tochigi, M, additional, Onitsuka, T, additional, Yamasue, H, additional, Matsuo, K, additional, Iidaka, T, additional, Iwata, N, additional, Suzuki, M, additional, Takeda, M, additional, Kasai, K, additional, and Ozaki, N, additional

Published
2014
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220. Enhanced Hot Electron Localization and Heating in High-Contrast Ultra-Intense Laser Irradiation of Sharp Micro-Cone Targets

Author

Rassuchine, J., D’Humières, E., Baton, S. D., Guillou, P., Koenig, M., Fuchs, J., Audebert, P., Kodama, R., Nakatsutsumi, M., Ozaki, N., Batani, D., Morace, A., Redaelli, R., Gremillet, L., Rousseaux, C., Dorchies, F., Fourment, C., Santos, J. J., Adams, J., Korgan, G., Malekos, S., Hansen, S. B., Shepherd, R., Flippo, K., Gaillard, S., Sentoku, Y., and Cowan, T. E.

Abstract

We report experiments demonstrating enhanced coupling efficiencies employing high contrast laser irradiation of nano-fabricated conical targets. Peak temperatures near 200 eV are observed with modest laser energy (10 J), revealing similarities in hot electron localization and material heating to reduced mass targets. Collisional particle-in-cell simulations attribute this enhancement to self-generated resistive magnetic fields forming within the cone wall, which effectively confine the energetic electrons to heat a reduced volume at the cone tip.

Published
2009

221. Enhanced hot-electron localization and heating in high-contrast ultraintense laser irradiation of microcone targets

Author

Rassuchine, J., Humieres, E. D., Baton, S. D., Guillou, P., Koenig, M., Chahid, M., Perez, F., Fuchs, J., patrick Audebert, Kodama, R., Nakatsutsumi, M., Ozaki, N., Batani, D., Morace, A., Redaelli, R., Gremillet, L., Rousseaux, C., Dorchies, F., Fourment, C., Santos, J. J., Adams, J., Korgan, G., Malekos, S., Hansen, S. B., Shepherd, R., Flippo, K., Sentoku, Y., Cowan, T. E., Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire pour l'utilisation des lasers intenses (LULI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Critical Care Department, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Institut of Applied Physics (IAP), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Graduate School of Engineering, Osaka University, Graduate School of Engineering, Graduate School of Engineering [Suita, Osaka], Osaka University [Osaka], Dipartimento di Fisica 'Giuseppe Occhialini' = Department of Physics 'Giuseppe Occhialini' [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), DAM Île-de-France (DAM/DIF), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB), Osaka University, and Università degli Studi di Milano-Bicocca [Milano] (UNIMIB)

Subjects
[PHYS]Physics [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2009

222. Study of iron under high pressure conditions using isentropic compression

Author

Wei, H. G., Brambrink, E., Benuzzi-Mounaix, A., Ravasio, A., Guillaume Morard, Rességuier, T., Lescoute, E., Ozaki, N., Miyanishi, K., Zhao, G., Liang, Z. T., Koenig, M., Guyot, F., School of Physics, Shandong University, Laboratoire pour l'utilisation des lasers intenses (LULI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), National Astronomical Observatories, Chinese Academy of Sciences, Chinese Academy of Sciences [Beijing] (CAS), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de recherche pour le développement [IRD] : UR206-Centre National de la Recherche Scientifique (CNRS), Laboratoire de combustion et de détonique (LCD), Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS), Graduate School of Engineering [Suita, Osaka], Osaka University [Osaka], Institut de minéralogie et de physique des milieux condensés (IMPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique du Globe de Paris (IPGP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de recherche pour le développement [IRD] : UR206-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Graduate School of Engineering, Osaka University, Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
iron, phase transformation, Isentropic compression, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, PACS : 52.50.Jm, 91.35.Cb, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience; We use directly driven method to compress the iron along isentropic path. By adjusting the pulse intensity of laser to increase with time, we directly ablated the iron target with laser to achieve isentropic compression. Rear surface velocities of the iron targets were recorded by VISAR (Velocity Interferometer System for Any Reflector). The iron (bcc) to (hcp) phase transformation was clearly observed. Experiment results were compared with simulations

Published
2009

223. Recent experiment on fast electron transport in ultra-high intensity laser interaction

Author

Batani, D., Baton, S., Koenig, M., Guillou, P., Loupias, B., Vinci, T., Rousseaux, C., Gremillet, L., Morace, A., Redaelli, R., Nakatsutsumi, M., Kodama, R., Ozaki, N., Norimatsu, T., Rassuchine, J., Cowan, T., Dorchies, F., Fourment, C., Santos, J. J., Dipartimento di Fisica 'Giuseppe Occhialini' = Department of Physics 'Giuseppe Occhialini' [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Laboratoire pour l'utilisation des lasers intenses (LULI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Thomas Jefferson National Accelerator Facility (Jefferson Lab), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Graduate School of Engineering, Osaka University, Graduate School of Engineering, Graduate School of Engineering [Suita, Osaka], Osaka University [Osaka], Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Azechi, H. and Hammel, B. and Gauthier, J. C., Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB), and Osaka University

Subjects
[PHYS]Physics [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2008

226. Laser-driven shock waves for the study of extreme states of matter

Author

BENUZZI MOUNAIX, A., Koenig, M., Ravasio, A., Vinci, T., Ozaki, N., RABEC LE GLOAHEC, M., Loupias, B., Huser, G., Henry, E., Bouquet, S., Michaut, C., Hicks, D., Mackinnon, A., Patel, P., Park, H. S., LE PAPE, S., Boehly, T., Borghesi, M., Cecchetti, C., Notley, M., Clark, R., Bandyopadhyay, S., Atzeni, Stefano, Schiavi, Angelo, Aglitskiy, Y., Faenov, A., Pikuz, T., Batani, D., and Tanaka, R. DEZULIAN AND K.

Published
2006

227. Progress in the study of Warm Dense Matter

Author

Koenig, M., Benuzzi-Mounaix, A., Vinci, T., Ozaki, N., Lepape, S., Batani, D., Huser, G., Hall, T., Hicks, D., Mackinnon, A.J., Patel, P.K., Boehly, T., Borghesi, Marco, Kar, Satyabrata, and Romagnani, Lorenzo

Subjects
Nuclear and High Energy Physics, Physics and Astronomy(all), Condensed Matter Physics
Published
2005

229. Radiative Shock Experiments at LULI

Author

Koenig, M., primary, Vinci, T., additional, Benuzzi-Mounaix, A., additional, Lepape, S., additional, Ozaki, N., additional, Bouquet, S., additional, Boireau, L., additional, Leygnac, S., additional, Michaut, C., additional, Stehle, C., additional, Chièze, J.-P., additional, Batani, D., additional, Hall, T., additional, Tanaka, K., additional, and Yoshida, M., additional

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235. A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

Author

Ikeda, M, Takahashi, A, Kamatani, Y, Okahisa, Y, Kunugi, H, Mori, N, Sasaki, T, Ohmori, T, Okamoto, Y, Kawasaki, H, Shimodera, S, Kato, T, Yoneda, H, Yoshimura, R, Iyo, M, Matsuda, K, Akiyama, M, Ashikawa, K, Kashiwase, K, Tokunaga, K, Kondo, K, Saito, T, Shimasaki, A, Kawase, K, Kitajima, T, Matsuo, K, Itokawa, M, Someya, T, Inada, T, Hashimoto, R, Inoue, T, Akiyama, K, Tanii, H, Arai, H, Kanba, S, Ozaki, N, Kusumi, I, Yoshikawa, T, Kubo, M, and Iwata, N

Abstract

Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In the present GWAS (Phase I/II), which included 2964 BD and 61 887 control subjects from the Japanese population, we detected a novel susceptibility locus at 11q12.2 (rs28456, P=6.4 × 10−9), a region known to contain regulatory genes for plasma lipid levels (FADS1/2/3). A subsequent meta-analysis of Phase I/II and the Psychiatric GWAS Consortium for BD (PGC-BD) identified another novel BD gene, NFIX (Pbest=5.8 × 10−10), and supported three regions previously implicated in BD susceptibility: MAD1L1 (Pbest=1.9 × 10−9), TRANK1 (Pbest=2.1 × 10−9) and ODZ4 (Pbest=3.3 × 10−9). Polygenicity of BD within Japanese and trans-European-Japanese populations was assessed with risk profile score analysis. We detected higher scores in BD cases both within (Phase I/II) and across populations (Phase I/II and PGC-BD). These were defined by (1) Phase II as discovery and Phase I as target, or vice versa (for ‘within Japanese comparisons’, Pbest~10−29, R2~2%), and (2) European PGC-BD as discovery and Japanese BD (Phase I/II) as target (for ‘trans-European-Japanese comparison,’ Pbest~10−13, R2~0.27%). This ‘trans population’ effect was supported by estimation of the genetic correlation using the effect size based on each population (liability estimates~0.7). These results indicate that (1) two novel and three previously implicated loci are significantly associated with BD and that (2) BD ‘risk’ effect are shared between Japanese and European populations.

Published
2018
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236. Hugoniot and mean ionization of laser-shocked Ge-doped plastic

Author

Huser, G., primary, Ozaki, N., additional, Sano, T., additional, Sakawa, Y., additional, Miyanishi, K., additional, Salin, G., additional, Asaumi, Y., additional, Kita, M., additional, Kondo, Y., additional, Nakatsuka, K., additional, Uranishi, H., additional, Yang, T., additional, Yokoyama, N., additional, Galmiche, D., additional, and Kodama, R., additional

Published
2013
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248. Innervation of Extrahepatic Biliary Tract, With Special Reference to the Direct Bidirectional Neural Connections of the Gall Bladder, Sphincter of Oddi and Duodenum in Suncus murinus, in Whole-Mount Immunohistochemical Study.

Author

Yi, S.‐Q., Ren, K., Kinoshita, M., Takano, N., Itoh, M., and Ozaki, N.

Subjects
INNERVATION, BILIARY tract, GALLBLADDER, SPHINCTER of Oddi, DUODENUM, SUNCUS murinus, IMMUNOHISTOCHEMISTRY
Abstract

Sphincter of Oddi dysfunction is one of the most important symptoms in post-cholecystectomy syndrome. Using either electrical or mechanical stimulation and retrogradely transported neuronal dyes, it has been demonstrated that there are direct neural pathways connecting gall bladder and the sphincter of Oddi in the Australian opossum and the golden hamster. In the present study, we employed whole-mount immunohistochemistry staining to observe and verify that there are two different plexuses of the extrahepatic biliary tract in Suncus murinus. One, named Pathway One, showed a fine, irregular but dense network plexus that ran adhesively and resided on/in the extrahepatic biliary tract wall, and the plexus extended into the intrahepatic area. On the other hand, named Pathway Two, exhibiting simple, thicker and straight neural bundles, ran parallel to the surface of the extrahepatic biliary tract and passed between the gall bladder and duodenum, but did not give off any branches to the liver. Pathway Two was considered to involve direct bidirectional neural connections between the duodenum and the biliary tract system. For the first time, morphologically, we demonstrated direct neural connections between gall bladder and duodenum in S. murinus. Malfunction of the sphincter of Oddi may be caused by injury of the direct neural pathways between gall bladder and duodenum by cholecystectomy. From the viewpoint of preserving the function of the major duodenal papilla and common bile duct, we emphasize the importance of avoiding kocherization of the common bile duct so as to preserve the direct neural connections between gall bladder and sphincter of Oddi. [ABSTRACT FROM AUTHOR]

Published
2016
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249. Genome-wide association study identifies a potent locus associated with human opioid sensitivity

Author

Nishizawa, D, primary, Fukuda, K, additional, Kasai, S, additional, Hasegawa, J, additional, Aoki, Y, additional, Nishi, A, additional, Saita, N, additional, Koukita, Y, additional, Nagashima, M, additional, Katoh, R, additional, Satoh, Y, additional, Tagami, M, additional, Higuchi, S, additional, Ujike, H, additional, Ozaki, N, additional, Inada, T, additional, Iwata, N, additional, Sora, I, additional, Iyo, M, additional, Kondo, N, additional, Won, M-J, additional, Naruse, N, additional, Uehara-Aoyama, K, additional, Itokawa, M, additional, Koga, M, additional, Arinami, T, additional, Kaneko, Y, additional, Hayashida, M, additional, and Ikeda, K, additional

Published
2012
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