12,876 results on '"Pérez González, A."'
Search Results
202. Characterization of Dissimilar Welds of Carbon Steels and Ni-Filler Alloy
- Author
-
Arganis-Juárez, C. R., Aguilar-Torres, J. A., Ramírez-Ramírez, J. H., Pérez-González, F. A., Garza-Montes-de-Oca, N. F., and Colás, R.
- Published
- 2023
- Full Text
- View/download PDF
203. Metamaterial adhesives for programmable adhesion through reverse crack propagation
- Author
-
Hwang, Dohgyu, Lee, Chanhong, Yang, Xingwei, Pérez-González, Jose M., Finnegan, Jason, Lee, Bernard, Markvicka, Eric J., Long, Rong, and Bartlett, Michael D.
- Published
- 2023
- Full Text
- View/download PDF
204. Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction
- Author
-
Jorge Barbazan, Carlos Pérez-González, Manuel Gómez-González, Mathieu Dedenon, Sophie Richon, Ernest Latorre, Marco Serra, Pascale Mariani, Stéphanie Descroix, Pierre Sens, Xavier Trepat, and Danijela Matic Vignjevic
- Subjects
Science - Abstract
Abstract During tumor progression, cancer-associated fibroblasts (CAFs) accumulate in tumors and produce an excessive extracellular matrix (ECM), forming a capsule that enwraps cancer cells. This capsule acts as a barrier that restricts tumor growth leading to the buildup of intratumoral pressure. Combining genetic and physical manipulations in vivo with microfabrication and force measurements in vitro, we found that the CAFs capsule is not a passive barrier but instead actively compresses cancer cells using actomyosin contractility. Abrogation of CAFs contractility in vivo leads to the dissipation of compressive forces and impairment of capsule formation. By mapping CAF force patterns in 3D, we show that compression is a CAF-intrinsic property independent of cancer cell growth. Supracellular coordination of CAFs is achieved through fibronectin cables that serve as scaffolds allowing force transmission. Cancer cells mechanosense CAF compression, resulting in an altered localization of the transcriptional regulator YAP and a decrease in proliferation. Our study unveils that the contractile capsule actively compresses cancer cells, modulates their mechanical signaling, and reorganizes tumor morphology.
- Published
- 2023
- Full Text
- View/download PDF
205. Ongoing harlequin toad declines suggest the amphibian extinction crisis is still an emergency
- Author
-
Stefan Lötters, Amadeus Plewnia, Alessandro Catenazzi, Kelsey Neam, Andrés R. Acosta-Galvis, Yesenia Alarcon Vela, Joshua P. Allen, Juan O. Alfaro Segundo, Ana de Lourdes Almendáriz Cabezas, Gilbert Alvarado Barboza, Kleiton R. Alves-Silva, Marvin Anganoy-Criollo, Ernesto Arbeláez Ortiz, Jackeline D. Arpi Lojano, Alejandro Arteaga, Onil Ballestas, Diego Barrera Moscoso, José D. Barros-Castañeda, Abel Batista, Manuel H. Bernal, Esteban Betancourt, Youszef Oliveira da Cunha Bitar, Philipp Böning, Laura Bravo-Valencia, José F. Cáceres Andrade, Diego Cadenas, Juan Carlos Chaparro Auza, Giovanni A. Chaves-Portilla, Germán Chávez, Luis A. Coloma, Claudia F. Cortez-Fernandez, Elodie A. Courtois, Jaime Culebras, Ignacio De la Riva, Vladimir Diaz, Luis C. Elizondo Lara, Raffael Ernst, Sandra V. Flechas, Thibaut Foch, Antoine Fouquet, Carmen Z. García Méndez, Juan Elias García-Pérez, Diego A. Gómez-Hoyos, Samuel C. Gomides, Jorge Guerrel, Brian Gratwicke, Juan M. Guayasamin, Edgardo Griffith, Valia Herrera-Alva, Roberto Ibáñez, Carlos Iván Idrovo, Andrés Jiménez Monge, Rafael F. Jorge, Alisha Jung, Blake Klocke, Margarita Lampo, Edgar Lehr, Carrie H. R. Lewis, Erik D. Lindquist, Yeny R. López-Perilla, Glib Mazepa, Guido F. Medina-Rangel, Andrés Merino Viteri, Kevin Mulder, Mauricio Pacheco-Suarez, Andry Pereira-Muñoz, José Luis Pérez-González, Maria Alejandra Pinto Erazo, Adolfo Gustavo Pisso Florez, Marcos Ponce, Vicky Poole, Amanda B. Quezada Riera, Aarón J. Quiroz, Michelle Quiroz-Espinoza, Alejandro Ramírez Guerra, Juan P. Ramírez, Steffen Reichle, Hugo Reizine, Mauricio Rivera-Correa, Bernardo Roca-Rey Ross, Andrés Rocha-Usuga, Miguel Trefaut Rodrigues, Sintana Rojas Montaño, Daniela C. Rößler, Luis Alberto Rueda Solano, Celsa Señaris, Alexander Shepack, Fausto R. Siavichay Pesántez, Anton Sorokin, Andrea Terán-Valdez, Grecia Torres-Ccasani, Pablo C. Tovar-Siso, Lina M. Valencia, David A. Velásquez-Trujillo, Michael Veith, Pablo J. Venegas, Jeferson Villalba-Fuentes, Rudolf von May, Juan F. Webster Bernal, and Enrique La Marca
- Subjects
Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Abstract Biodiversity loss is extreme in amphibians. Despite ongoing conservation action, it is difficult to determine where we stand in overcoming their extinction crisis. Among the most threatened amphibians are the 131 Neotropical harlequin toads. Many of them declined since the 1980s with several considered possibly extinct. Recently, more than 30 species have been rediscovered, raising hope for a reversing trend in the amphibian extinction crisis. We use past and present data available for harlequin toads (Atelopus), to examine whether the amphibian extinction crisis is still in an emergency state. Since 2004 no species has improved its population status, suggesting that recovery efforts have not been successful. Threats include habitat change, pathogen spread and climate change. More mitigation strategies need implementation, especially habitat protection and disease management, combined with captive conservation breeding. With harlequin toads serving as a model, it is clear that the amphibian extinction crisis is still underway.
- Published
- 2023
- Full Text
- View/download PDF
206. Reporting guidelines and a touch of critical appraisal
- Author
-
Pilar Aizpurua Galdeano, Paz González Rodríguez, María Aparicio Rodrigo, Nieves Balado Insunza, Elena Pérez González, Juan Ruiz-Canela Cáceres, and Eduardo Ortega Páez
- Subjects
Escritura médica: estándares ,Lista de verificación ,Diseño de investigaciones epidemiológicas ,Pediatrics ,RJ1-570 - Abstract
The biomedical research process must follow certain quality criteria in its design and development to ensure that the results are credible and reliable. Once completed, the time comes to write an article for publication. The article must present in sufficient detail, and in a clear and transparent manner, all the information on the research work that has been carried out. In this way, readers, after a critical reading of the published content, will be able to judge the validity and relevance of the study and, if they so wish, make use of the findings.In order to improve the description of the research process for publication, a series of guidelines have been developed which, in a simple and structured way, guide authors in the preparation of a manuscript. They are presented in the form of a list, flowchart, or structured text, and are an invaluable aid when writing an article.This article presents the reporting guidelines for the most common designs along with the corresponding checklists. Resumen: El proceso de investigación biomédica debe seguir unos criterios de calidad en su diseño y elaboración, que garanticen que los resultados son creíbles y fiables. Una vez finalizado, llega el momento de escribir un artículo para su publicación. Este debe presentar con suficiente detalle, y de forma clara y transparente, toda la información del trabajo de investigación realizado. De esta forma, los lectores, tras una lectura crítica de lo publicado, podrán juzgar la validez y la relevancia del estudio, y si lo consideran, utilizar los hallazgos.Con el objetivo de mejorar la descripción del proceso de investigación para su publicación, se han desarrollado una serie de guías que, de forma sencilla y estructurada, orientan a los autores a la hora de elaborar un manuscrito. Se presentan en forma de lista, diagrama de flujo, o texto estructurado, y son una ayuda inestimable a la hora de escribir un artículo.Este artículo presenta las guías de elaboración de manuscritos de los diseños más habituales, con sus listas de verificación.
- Published
- 2023
- Full Text
- View/download PDF
207. El papel de la cirugía mínimamente invasiva de columna en el tratamiento de las metástasis vertebrales: una revisión narrativa
- Author
-
D. Garríguez-Pérez, A. Vargas Jiménez, R. Luque Pérez, A. Carrascosa Granada, D. Oñate Martínez-Olascoaga, J.L. Pérez González, I. Domínguez Esteban, and F. Marco
- Subjects
Minimally invasive surgery ,Vertebral metastasis ,MISS ,MIS ,Orthopedic surgery ,RD701-811 - Abstract
Resumen: Introducción: Las metástasis vertebrales son un problema muy frecuente y asocian un deterioro importante de la calidad de vida en los pacientes oncológicos. El objetivo de esta revisión es determinar el encaje de las técnicas quirúrgicas mínimamente invasivas dentro del manejo de esta entidad. Métodos: Se realizó una revisión bibliográfica en las bases de datos Google Scholar, PubMed, Scopus y Cochrane. Se revisaron los artículos publicados en los últimos 10 años que fueran de una relevancia y calidad adecuadas. Resultados: Tras el cribado de los 2.184 trabajos identificados inicialmente en las distintas bases de datos, se incluyeron un total de 24 artículos en esta revisión. Conclusión: La cirugía mínimamente invasiva de columna es especialmente útil en pacientes oncológicos frágiles con metástasis vertebrales por la reducida comorbilidad que presentan las técnicas que se engloban en ella en comparación con la de la cirugía abierta convencional. Los avances en tecnología aplicada a la cirugía, como la navegación y la robótica, mejoran la precisión y reducen las complicaciones de esta técnica. Abstract: Background: Spinal metastases are a very common problem which dramatically affects the quality of life of cancer patients. The objective of this review is to address the issue of how minimally invasive surgery can play an important role in treating this pathology. Methods: A literature review was performed, searching in the Google Scholar, PubMed, Scopus and Cochrane databases. Relevant and quality papers published within the last 10 years were included in the review. Results: After screening the 2184 initially identified registers, a total of 24 articles were included for review. Conclusion: Minimally invasive spine surgery is specially convenient for fragile cancer patients with spinal metastases, because of its reduced comorbidity compared to conventional open surgery. Technological advances in surgery, such as navigation and robotics, improve accuracy and safety in this technique.
- Published
- 2023
- Full Text
- View/download PDF
208. El papel de la cirugía mínimamente invasiva de columna en el tratamiento de las metástasis vertebrales (parte 1): una revisión clínica
- Author
-
A. Carrascosa-Granada, D. Garríguez Perez, A. Vargas-Jiménez, R. Luque Perez, D.O. Martínez-Olascoagoa, J.L. Pérez González, I. Domínguez Esteban, and F. Marco Martínez
- Subjects
Spinal metastasis ,Minimally invasive spine surgery ,Open surgery ,Orthopedic surgery ,RD701-811 - Abstract
Resumen: Las metástasis espinales representan una importante carga sobre la calidad de vida en los pacientes afectados por una enfermedad oncológica activa, debido a la alta incidencia de síndromes dolorosos, deformidad espinal y deterioro neurológico. La cirugía juega un papel determinante a la hora de mejorar la calidad de vida mediante el control del dolor, el restablecimiento de la función neurológica y el mantenimiento de la estabilidad espinal, además de contribuir a la respuesta de la terapia médica. La cirugía mínimamente invasiva (MIS) es una opción de tratamiento en determinados pacientes con alto riesgo quirúrgico, ya que tiene una baja tasa de complicaciones, de sangrado intraoperatorio, de estancia hospitalaria y ofrece resultados similares a la cirugía abierta.Presentamos en esta revisión el papel de la MIS en esta enfermedad, y algunos casos tratados en nuestro centro hospitalario. Abstract: Spinal metastases represent a significant burden on the quality of life in patients affected by active oncological disease due to the high incidence of pain syndromes, spinal deformity, and neurological impairment. Surgery plays a decisive role in improving quality of life by controlling pain, restoring neurological function and maintaining spinal stability, as well as contributing to the response to medical therapy. Minimally invasive surgery (MIS) is a treatment option in certain patients with high surgical risk since it has a low rate of complications, intraoperative bleeding, hospital stay, and offers similar results to open surgery.In this review, we present the role of MIS in this pathology and some cases treated in our hospital.
- Published
- 2023
- Full Text
- View/download PDF
209. Geothermal food dehydrator system, operation and sensory analysis, and dehydrated pineapple quality
- Author
-
Eduardo Pérez‐González, Patricia Severiano‐Pérez, Héctor M. Aviña‐Jiménez, and Olga Del C. Velázquez‐Madrazo
- Subjects
food dehydration ,geothermal energy ,microbiological analysis ,physicochemical characteristics ,sensory profile ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract Food dehydration is a preservation technique that guarantees its supply. Food like vegetables and fruits are traditionally dehydrated with natural gas or solar energy, however, this work demonstrates the feasibility of doing it with energy from a geothermal power plant in Nayarit, Mexico. Different species of pineapple (Miel, Cayenne, and Esmeralda) were dehydrated at different temperatures from 64 to 80°C and the safety of the product was subsequently verified, for these aerobic mesophiles (
- Published
- 2023
- Full Text
- View/download PDF
210. Novelty detection in an auditory oddball task on freely moving rats
- Author
-
Laura Quintela-Vega, Camilo J. Morado-Díaz, Gonzalo Terreros, Jazmín S. Sánchez, David Pérez-González, and Manuel S. Malmierca
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Abstract The relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repeating stimuli and different variations of the classic oddball paradigm, can detect deviant tones, and this discriminability resembles the properties that are typical of neuronal adaptation described in previous studies. Moreover, the auditory brainstem response (ABR) latency decreases after training, a finding consistent with the notion that animals develop a type of plasticity to auditory stimuli. Our study suggests the existence of a form of long-term memory that may modulate the level of neuronal adaptation according to its behavioural relevance, and sets the ground for future experiments that will help to disentangle the functional mechanisms that govern behavioural habituation and its relation to neuronal adaptation.
- Published
- 2023
- Full Text
- View/download PDF
211. Differential attenuation in star-forming galaxies at 0.3 $\lesssim$ $z$ $\lesssim$ 1.5 in the SHARDS/CANDELS field
- Author
-
Rodríguez-Muñoz, L., Rodighiero, G., Pérez-González, P. G., Talia, M., Baronchelli, I., Morselli, L., Renzini, A., Puglisi, A., Grazian, A., Zanella, A., Mancini, C., Feltre, A., Romano, M., García, A. Vidal, Franceschini, A., Pampliega, B. Alcalde, Cassata, P., Costantin, L., Sánchez, H. Domínguez, Espino-Briones, N., Iani, E., Koekemoer, A., Lumbreras-Calle, A., and Rodríguez-Espinosa, J. M.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We use a sample of 706 galaxies, selected as [OII]$\lambda$3727 ([OII]) emitters in the Survey for High-$z$ Absorption Red and Dead Sources (SHARDS) on the CANDELS/GOODS-N field, to study the differential attenuation of the nebular emission with respect to the stellar continuum. The sample includes only galaxies with a counterpart in the infrared and $\mathrm{log}_{10}(M_{*}/\mathrm{M}_{\odot})$ $>$ 9, over the redshift interval 0.3 $\lesssim$ $z$ $\lesssim$ 1.5. Our methodology consists in the comparison of the star formation rates inferred from [OII] and H$\alpha$ emission lines with a robust quantification of the total star-forming activity (${SFR}_{\mathrm{TOT}}$) that is independently estimated based on both infrared and ultraviolet (UV) luminosities. We obtain $f$$=$$E(B-V)_{\mathrm{stellar}}$/$E(B-V)_{\mathrm{nebular}}$ $=$ 0.69$^{0.71}_{0.69}$ and 0.55$^{0.56}_{0.53}$ for [OII] and H$\alpha$, respectively. Our resulting $f$-factors display a significant positive correlation with the UV attenuation and shallower or not-significant trends with the stellar mass, the $SFR_{\mathrm{TOT}}$, the distance to the main sequence, and the redshift. Finally, our results favour an average nebular attenuation curve similar in shape to the typical dust curve of local starbursts., Comment: 23 pages, 10 figures, 3 tables; accepted for publication in MNRAS
- Published
- 2021
- Full Text
- View/download PDF
212. Simulating infrared spectro-photometric surveys with a SPRITZ
- Author
-
Bisigello, L., Gruppioni, C., Calura, F., Feltre, A., Pozzi, F., Vignali, C., Barchiesi, L., Rodighiero, G., Negrello, M., Carrera, F. J., Dasyra, K. M., Fernández-Ontiveros, J. A., Giard, M., Hatziminaoglou, E., Kaneda, H., Lusso, E., Pereira-Santaella, M., Pérez-González, P. G., Ricci, C., Schaerer, D., Spinoglio, L., and Wang, L.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Mid- and far-infrared (IR) photometric and spectroscopic observations are fundamental to a full understanding of the dust-obscured Universe and the evolution of both star formation and black hole accretion in galaxies. In this work, using the specifications of the SPace Infrared telescope for Cosmology and Astrophysics (SPICA) as a baseline, we investigate the capability to study the dust-obscured Universe of mid- and far-IR photometry at 34 and 70 $\mu$m and low-resolution spectroscopy at 17-36 $\mu$m using the state-of-the-art Spectro-Photometric Realisations of Infrared-selected Targets at all-z (SPRITZ) simulation. This investigation is also compared to the expected performance of the Origins Space Telescope and the Galaxy Evolution Probe. The photometric view of the Universe of a SPICA-like mission could cover not only bright objects (e.g. L$_{IR}$>10$^{12}$L$_\odot$) up to z=10, but also normal galaxies(L$_{IR}$<10$^{11}$L$_\odot$) up to z$\sim$4. At the same time, the spectroscopic observations of such mission could also allow us to estimate the redshifts and study the physical properties for thousands of star-forming galaxies and active galactic nuclei by observing the polycyclic aromatic hydrocarbons and a large set of IR nebular emission lines. In this way, a cold, 2.5-m size space telescope with spectro-photometric capability analogous to SPICA, could provide us with a complete three-dimensional (i.e. images and integrated spectra) view of the dust-obscured Universe and the physics governing galaxy evolution up to z$\sim$4., Comment: 22 pages, 17 figures, 4 tables, accepted for publication in PASA
- Published
- 2021
- Full Text
- View/download PDF
213. MicroBooNE and the $\nu_e$ Interpretation of the MiniBooNE Low-Energy Excess
- Author
-
Argüelles, C. A., Esteban, I., Hostert, M., Kelly, K. J., Kopp, J., Machado, P. A. N., Martinez-Soler, I., and Perez-Gonzalez, Y. F.
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Experiment - Abstract
A new generation of neutrino experiments is testing the $4.8\sigma$ anomalous excess of electron-like events observed in MiniBooNE. This is of huge importance for particle physics, astrophysics, and cosmology, not only because of the potential discovery of physics beyond the Standard Model, but also because the lessons we will learn about neutrino-nucleus interactions will be crucial for the worldwide neutrino program. MicroBooNE has recently released results that appear to disfavor several explanations of the MiniBooNE anomaly. Here, we show quantitatively that MicroBooNE results, while a promising start, unquestionably do not probe the full parameter space of sterile neutrino models hinted at by MiniBooNE and other data, nor do they probe the $\nu_e$ interpretation of the MiniBooNE excess in a model-independent way. Our analysis code is fully available in https://github.com/Harvard-Neutrino/MicroBooNE-analysis-2021., Comment: 7+6 pages, 5+9 figures. v2: version published in Phys.Rev.Lett. New supplemental material with test statistic coverage checks, validation of unfolding method, and Asimov sensitivity comparison. Typos and mislabeling fixed
- Published
- 2021
- Full Text
- View/download PDF
214. $pp$ Solar Neutrinos at DARWIN
- Author
-
de Gouvêa, André, McGinness, Emma, Martinez-Soler, Ivan, and Perez-Gonzalez, Yuber F.
- Subjects
High Energy Physics - Phenomenology - Abstract
The DARWIN collaboration recently argued that DARWIN (DARk matter WImp search with liquid xenoN) can collect, via neutrino--electron scattering, a large, useful sample of solar $pp$-neutrinos, and measure their survival probability with sub-percent precision. We explore the physics potential of such a sample in more detail. We estimate that, with 300 ton-years of data, DARWIN can also measure, with the help of current solar neutrino data, the value of $\sin^2\theta_{13}$, with the potential to exclude $\sin^2\theta_{13}=0$ close to the three-sigma level. We explore in some detail how well DARWIN can constrain the existence of a new neutrino mass-eigenstate $\nu_4$ that is quasi-mass-degenerate with $\nu_1$ and find that DARWIN's sensitivity supersedes that of all current and near-future searches for new, very light neutrinos. In particular, DARWIN can test the hypothesis that $\nu_1$ is a pseudo-Dirac fermion as long as the induced mass-squared difference is larger than $10^{-13}$ eV$^2$, one order of magnitude more sensitive than existing constraints. Throughout, we allowed for the hypotheses that DARWIN is filled with natural xenon or $^{136}$Xe-depleted xenon., Comment: 14 pages, 7 figures
- Published
- 2021
- Full Text
- View/download PDF
215. VRAIN-UPV MLLP's system for the Blizzard Challenge 2021
- Author
-
Pérez-González-de-Martos, Alejandro, Sanchis, Albert, and Juan, Alfons
- Subjects
Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
This paper presents the VRAIN-UPV MLLP's speech synthesis system for the SH1 task of the Blizzard Challenge 2021. The SH1 task consisted in building a Spanish text-to-speech system trained on (but not limited to) the corpus released by the Blizzard Challenge 2021 organization. It included 5 hours of studio-quality recordings from a native Spanish female speaker. In our case, this dataset was solely used to build a two-stage neural text-to-speech pipeline composed of a non-autoregressive acoustic model with explicit duration modeling and a HiFi-GAN neural vocoder. Our team is identified as J in the evaluation results. Our system obtained very good results in the subjective evaluation tests. Only one system among other 11 participants achieved better naturalness than ours. Concretely, it achieved a naturalness MOS of 3.61 compared to 4.21 for real samples.
- Published
- 2021
216. ALP Dark Matter in a Primordial Black Hole Dominated Universe
- Author
-
Bernal, Nicolás, Perez-Gonzalez, Yuber F., Xu, Yong, and Zapata, Óscar
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We investigate the phenomenological consequences of axion-like particle (ALP) dark matter with an early matter domination triggered by primordial black holes (PBHs). We focus on light BHs with masses smaller than $\sim 10^9~$g which fully evaporate before Big Bang nucleosynthesis. We numerically solve the coupled Boltzmann equations, carefully taking the greybody factors and BH angular momentum into account. We find that the entropy injection from PBH evaporation dilutes the ALP relic abundance originally produced via the vacuum misalignment mechanism, opening the parameter space with larger scales $f_a$ or, equivalently, smaller ALP-photon couplings $g_{a\gamma}$, within the reach of future detectors as ABRACADABRA, KLASH, ADMX, and DM-Radio. Moreover, the ALP minicluster masses can be several orders of magnitude larger if the early Universe features an PBH dominated epoch. For the relativistic ALPs produced directly from Hawking radiation, we find that their contribution to the dark radiation is within the sensitivity of next generation CMB experiments. For the sake of completeness, we also revisit the particular case of the QCD axion., Comment: 23 pages, 6 figures; V2: references updated; version accepted for publication in PRD
- Published
- 2021
- Full Text
- View/download PDF
217. Population-based Influenza and Respiratory Syncytial Virus Hospitalizations and In-hospital Mortality Rates Among Mexican Children Less Than Five Years of Age
- Author
-
Mata-Moreno, Gabriel, Bernal-Silva, Sofía, García-Sepúlveda, Christian A., González-Ortíz, Ana María, Ochoa-Pérez, Uciel R., Medina-Serpa, Aldo Uzziel, Pérez-González, Luis Fernando, and Noyola, Daniel E.
- Published
- 2024
- Full Text
- View/download PDF
218. Physical Treatments and Therapies for Androgenetic Alopecia
- Author
-
Siddhi Bianca Camila Lama, Luis Alfonso Pérez-González, Mehmet A. Kosoglu, Robert Dennis, and Daniel Ortega-Quijano
- Subjects
androgenetic alopecia ,hair loss ,microneedling ,laser hair therapy ,PEMF ,fractional lasers ,Medicine - Abstract
Androgenetic alopecia, the most common cause of hair loss affecting both men and women, is typically treated using pharmaceutical options, such as minoxidil and finasteride. While these medications work for many individuals, they are not suitable options for all. To date, the only non-pharmaceutical option that the United States Food and Drug Administration has cleared as a treatment for androgenetic alopecia is low-level laser therapy (LLLT). Numerous clinical trials utilizing LLLT devices of various types are available. However, a myriad of other physical treatments for this form of hair loss have been reported in the literature. This review evaluated the effectiveness of microneedling, pulsed electromagnetic field (PEMF) therapy, low-level laser therapy (LLLT), fractional laser therapy, and nonablative laser therapy for the treatment of androgenetic alopecia (AGA). It also explores the potential of multimodal treatments combining these physical therapies. The majority of evidence in the literature supports LLLT as a physical therapy for androgenetic alopecia. However, other physical treatments, such as nonablative laser treatments, and multimodal approaches, such as PEMF-LLLT, seem to have the potential to be equally or more promising and merit further exploration.
- Published
- 2024
- Full Text
- View/download PDF
219. Computerized Generation of Endodontic Files by Reproducing the Flute Grinding Manufacturing Process
- Author
-
Victor Roda-Casanova and Antonio Pérez-González
- Subjects
endodontic files ,computer-aided design ,computer-aided manufacturing ,Technology ,Biology (General) ,QH301-705.5 - Abstract
Background: File fracture during root canal treatment in endodontics is a major concern for clinicians. The strength of the file is strongly dependent on its geometry, material, and working conditions; finite element simulations are used to understand these failure mechanisms. One limitation of the models used for these simulations is the approximate geometric representation typically obtained by rotating and scaling a specific cross-section shape along the file length. Given the influence of file geometry on file strength, a more realistic representation based on the manufacturing method is needed. Methods: A computerized method was developed to generate the file geometry by simulating the flute grinding manufacturing process. This method generates the 3D geometry of the file starting from a blank and reproducing the motions of the file and grinding wheel. Results: The cross-section of the resulting geometry does not involve simple rotation and scaling but changes from the shank to the tip. The tilt angle of the grinding wheel affects the final geometry, thus altering the convexity of the cross-section. Several other parameters, such as the pitch and the radius of the grinding disc tip, impact the final geometry. Conclusions: The proposed computational method allows for the generation of endodontic file geometries that match those produced via the actual flute grinding method. This tool may help researchers and tool designers in the preparation of finite element models to assess the strength of realistic files.
- Published
- 2024
- Full Text
- View/download PDF
220. An Optimized Approach to Multistage Permanent Deformation Testing of Granular Materials
- Author
-
Erdrick Pérez-González and Jean-Pascal Bilodeau
- Subjects
deformation ,performance ,granular ,laboratory ,pavements ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Accurately characterizing permanent deformation in granular materials subjected to cyclic loading is crucial for pavement design. This paper introduces an alternative approach to characterizing permanent deformation in a framework that reduces the number of load cycle repetitions by applying an alternative analytical strategy based on plastic strain rate variation over time. The methodology uses a cycle-hardening approach to establish correlations between short-term (post-compaction) and long-term (shakedown state) plastic strain accumulation. This alternative approach provides an efficient means to accelerate the characterization of permanent deformation, ensuring the integrity and validity of the assessment in a more time-efficient and resource-optimized way.
- Published
- 2024
- Full Text
- View/download PDF
221. Nocturnal Glucose Profile According to Timing of Dinner Rapid Insulin and Basal and Rapid Insulin Type: An Insulclock® Connected Insulin Cap-Based Real-World Study
- Author
-
Fernando Gómez-Peralta, Xoan Valledor, Cristina Abreu, Elsa Fernández-Rubio, Laura Cotovad, Pedro Pujante, Sharona Azriel, Jesús Pérez-González, Alba Vallejo, Luis Ruiz-Valdepeñas, and Rosa Corcoy
- Subjects
ultrarapid insulin ,second-generation basal insulin ,nocturnal hyperglycemia ,nocturnal hypoglycemia ,connected insulin pen cap ,Biology (General) ,QH301-705.5 - Abstract
Background: A study to assess the glucose levels of people with type 1 diabetes (T1D) overnight, based on the insulin type and timing. Methods: A real-world, retrospective study of T1D, using multiple daily insulin injections. Continuous glucose monitoring and insulin injection data were collected for ten hours after dinner using the Insulclock® connected cap. Meal events were identified using the ROC detection methodology. The timing of the rapid insulin, second injections, and the type of insulin analogs used, were evaluated. Results: The nocturnal profiles (n = 775, 49 subjects) were analyzed. A higher glucose AUC of over 180 mg/dL was observed in subjects with delayed injections (number; %; mg/dL × h): −45–15 min (n = 136; 17.5%, 175.9 ± 271.0); −15–0 min (n = 231; 29.8%, 164.0 ± 2 37.1); 0 + 45 min (n = 408; 52.6%, 203.6 ± 260.9), (p = 0.049). The use of ultrarapid insulin (FiAsp®) (URI) vs. rapid insulin (RI) analogs was associated with less hypoglycemia events (7.1 vs. 13.6%; p = 0.005) and TBR70 (1.7 ± 6.9 vs. 4.6 ± 13.9%; p = 0.003). Users of glargine U300 vs. degludec had a higher TIR (70.7 vs. 58.5%) (adjusted R-squared: 0.22, p < 0.001). The use of a correction injection (n = 144, 18.6%) was associated with a higher number of hypoglycemia events (18.1 vs. 9.5%; p = 0.003), TBR70 (5.5 ± 14.2 vs. 3.0 ± 11.1%; p = 0.003), a glucose AUC of over 180 mg/dL (226.1 ± 257.8 vs. 178.0 ± 255.3 mg/dL × h; p = 0.001), and a lower TIR (56.0 ± 27.4 vs. 62.7 ± 29.6 mg/dL × h; p = 0.004). Conclusion: The dinner rapid insulin timing, insulin type, and the use of correction injections affect the nocturnal glucose profile in T1D.
- Published
- 2024
- Full Text
- View/download PDF
222. Spirochromene and spiroindene compounds as antioxidants
- Author
-
Morales-García, B. Carolina, Pérez-González, Adriana, and Galano, Annia
- Published
- 2024
- Full Text
- View/download PDF
223. Emotions and Construction of National Identities in Historical Education
- Author
-
Ortega-Sánchez, Delfín, Pagès Blanch, Joan, and Pérez-González, Carlos
- Abstract
In this study, the authors analyzed the relationship between emotions and the construction of identities, particularly national identity. We reviewed the current debate on the role of emotions and feelings in people's actions and in the configuration of their worldviews and practical actions. The world is witnessing a revival of ideologies that seemed to have been definitively banished from human thought and political action in the 20th century; however, it is being proved not only that they have survived and grown, but that they are also widely disseminated through networks and have come to shape the thinking of the many people who use them when deciding the future of their societies and how they want them to be governed. The growth of populism is based on emotions and on the most extremely nationalistic discourses. We analyzed, first of all, the influence of emotions on the perception of social reality and on the construction of historical and social knowledge. Next, we focused on the implications that emotions have had on the teaching of history and on the results of an international exploratory selection of particularly relevant research. Finally, as a conclusion, we suggest some ideas for the search of a balance that considers the weight of reason and emotion in the teaching and learning of history.
- Published
- 2020
224. Integrating Self-Regulated Learning and Individual Differences in the Prediction of University Academic Achievement across a Three-Year-Long Degree
- Author
-
Pérez-González, Juan-Carlos, Filella, Gemma, Soldevila, Anna, Faiad, Yasmine, and Sanchez-Ruiz, Maria-Jose
- Abstract
The study investigated the joint contribution of the self-regulated learning (SRL) and individual differences approaches to the prediction of university students' grade point average (GPA) obtained at three separate time points throughout their degree (3 years). We assessed cognitive (i.e., previous academic performance, cognitive ability, and cognitive SRL strategies) and non-cognitive variables (i.e., personality, trait emotional intelligence, motivation, and non-cognitive SRL strategies) in a sample of Spanish undergraduates. Results showed that GPA correlated with previous academic performance (i.e., combination of high school's GPA and college admission test score), academic self-efficacy, academic engagement, SRL strategies, and conscientiousness. Hierarchical regression analyses indicated that non-cognitive factors (i.e., academic engagement, academic self-efficacy, regulation of behavior and context, and conscientiousness) alone explained 17-25% of the variance in GPA across three years, and previous academic performance accounted up to an additional 25% of the variance, jointly reaching an explained variance of up to 50% in GPA. Specifically, academic engagement and regulation of behavior and context demonstrated incremental validity over and above cognitive predictors such as previous academic performance, inductive reasoning and regulation of cognition and metacognition. The role of intelligence, whether cognitive or emotional, was not as obvious as a predictor. Two nested structural equation models explained about 27-29% of the variance in a latent GPA factor exclusively from a proxy of a global variable of non-cognitive factors as a latent predictor, which is a novel and promising proof of its robust criterion validity. Implications and recommendations for future studies are discussed.
- Published
- 2022
- Full Text
- View/download PDF
225. Exploring Federated Learning Dynamics for Black-and-White-Box DNN Traitor Tracing.
- Author
-
Elena Rodríguez Lois and Fernando Pérez-González
- Published
- 2024
- Full Text
- View/download PDF
226. Q-COSMIC: Quantum Software Metrics Based on COSMIC (ISO/IEC19761).
- Author
-
Francisco Valdés-Souto, Héctor G. Pérez-González, and Carlos A. Pérez-Delgado
- Published
- 2024
- Full Text
- View/download PDF
227. DUNE atmospheric neutrinos: Earth Tomography
- Author
-
Kelly, Kevin J., Machado, Pedro A. N., Martinez-Soler, Ivan, and Perez-Gonzalez, Yuber F.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
In this paper we show that the DUNE experiment can measure the Earth's density profile by analyzing atmospheric neutrino oscillations. The crucial feature that enables such measurement is the detailed event reconstruction capability of liquid argon time projection chambers. This allows for studying the sub-GeV atmospheric neutrino component, which bears a rich oscillation phenomenology, strongly dependent on the matter potential sourced by the Earth. We provide a pedagogical discussion of the MSW and parametric resonances and their role in measuring the core and mantle densities. By performing a detailed simulation, accounting for particle reconstruction at DUNE, nuclear physics effects relevant to neutrino-argon interactions and several uncertainties on the atmospheric neutrino flux, we manage to obtain a robust estimate of DUNE's sensitivity to the Earth matter profile. We find that DUNE can measure the total mass of the Earth at 8.4% precision with an exposure of 400~kton-year. By accounting for previous measurements of the total mass and moment of inertia of the Earth, the core, lower mantle and upper mantle densities can be determined with 8.8%, 13% and 22% precision, respectively, for the same exposure. Finally, DUNE could take atmospheric neutrino data while the beam is being commissioned and far detector modules are up and running. For a low exposure run of 60~kton-year, which would correspond to two far detectors running for three years, we have found that the core density could be measured by DUNE at $\sim30\%$ precision., Comment: 35 pages, 19 figures, 2 tables
- Published
- 2021
- Full Text
- View/download PDF
228. Emission Line Galaxies in the SHARDS Frontier Fields I: Candidate Selection and the Discovery of Bursty H{\alpha} Emitters
- Author
-
Griffiths, Alex, Conselice, Christopher J., Ferreira, Leonardo, Ceverino, Daniel, Rosa-González, Daniel, Huertas-Company, Marc, Pampliega, Belén Alcalde, Pérez-González, Pablo G., Sanchez, Helena Dominguez, and Vega, Olga
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Emission line galaxies provide a crucial tool for the study of galaxy formation and evolution, providing a means to trace a galaxy's star formation history or metal enrichment, and to identify galaxies at a range of stellar masses. In this paper we present a study of emission line galaxies in the SHARDS Frontier Fields medium-band survey. Through detailed flux calibrations we combine the first results of the SHARDS-FF survey with existing Hubble Frontier Field data to select 1,098 candidate emission line galaxies from the Hubble Frontier Filed clusters Abell 370 and MACS J1149.5+2223. Furthermore, we implement this deep medium-band imaging to update photometric redshift estimates and stellar population parameters and discover 38 predominantly low-mass H{\alpha} emitters at redshifts 0.24 < z < 0.46. Overall, 27 of these sources have corresponding UV data from the Hubble Space Telescope which allows us to distinguish these sources and investigate the burstiness of their star formation histories. We find that more than 50% of our sample show an enhancement in H{\alpha} over UV, suggesting recent bursts in star formation on time scales of a few, to tens of megayears. We investigate these sources and find that they are typically low-mass disky galaxies with normal sizes. Their structures and star formation suggest that they are not undergoing mergers but are bursting due to alternative causes, such as gas accretion., Comment: Accepted at MNRAS, 18 pages, 15 figures
- Published
- 2021
- Full Text
- View/download PDF
229. Extensive Lensing Survey of Optical and Near-Infrared Dark Objects (El Sonido): HST H-Faint Galaxies behind 101 Lensing Clusters
- Author
-
Sun, Fengwu, Egami, Eiichi, Pérez-González, Pablo G., Smail, Ian, Caputi, Karina I., Bauer, Franz E., Rawle, Timothy D., Fujimoto, Seiji, Kohno, Kotaro, Dudzevičiūtė, Ugnė, Atek, Hakim, Bianconi, Matteo, Chapman, Scott C., Combes, Francoise, Jauzac, Mathilde, Jolly, Jean-Baptiste, Koekemoer, Anton M., Magdis, Georgios E., Rodighiero, Giulia, Rujopakarn, Wiphu, Schaerer, Daniel, Steinhardt, Charles L., Van der Werf, Paul, Walth, Gregory L., and Weaver, John R.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present a Spitzer/IRAC survey of H-faint ($H_{160} \gtrsim 26.4$, $<5\sigma$) sources in 101 lensing cluster fields. Across a CANDELS/Wide-like survey area of $\sim$648 arcmin$^2$ (effectively $\sim$221 arcmin$^2$ in the source plane), we have securely discovered 53 sources in the IRAC Channel-2 band (CH2, 4.5 $\mathrm{\mu m}$; median CH2$=22.46\pm0.11$ AB mag) that lack robust HST/WFC3-IR F160W counterparts. The most remarkable source in our sample, namely ES-009 in the field of Abell 2813, is the brightest H-faint galaxy at 4.5 $\mathrm{\mu m}$ known so far ($\mathrm{CH2}=20.48\pm0.03$ AB mag). We show that the H-faint sources in our sample are massive (median $M_\mathrm{star} = 10^{10.3\pm 0.3}$ $M_\odot$), star-forming (median star formation rate $=100_{-40}^{+60}$ $M_\odot$yr$^{-1}$) and dust-obscured ($A_V=2.6\pm0.3$) galaxies around a median photometric redshift of $z=3.9\pm0.4$. The stellar continua of 14 H-faint galaxies can be resolved in the CH2 band, suggesting a median circularized effective radius ($R_\mathrm{e,circ}$; lensing corrected) of $1.9\pm0.2$ kpc and $<1.5$ kpc for the resolved and whole samples, respectively. This is consistent with the sizes of massive unobscured galaxies at $z\sim4$, indicating that H-faint galaxies represent the dusty tail of the distribution of a wider galaxy population. Comparing with the ALMA dust continuum sizes of similar galaxies reported previously, we conclude that the heavy dust obscuration in H-faint galaxies is related to the compactness of both stellar and dust continua ($R_\mathrm{e,circ}\sim 1$ kpc). These H-faint galaxies make up $16_{-7}^{+13}$% of the galaxies in the stellar mass range of $10^{10}-10^{11.2}$ $M_\odot$ at $z=3\sim5$, contributing to $8_{-4}^{+8}$% of the cosmic star formation rate density in this epoch and likely tracing the early phase of massive galaxy formation., Comment: 26 pages, 10 figures, 3 tables. Accepted for publication in ApJ
- Published
- 2021
- Full Text
- View/download PDF
230. The physics potential of a reactor neutrino experiment with Skipper-CCDs: Searching for new physics with light mediators
- Author
-
Fernandez-Moroni, G., Harnik, R., Machado, P. A. N., Martinez-Soler, I., Perez-Gonzalez, Y. F., Rodrigues, D., and Rosauro-Alcaraz, S.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
We explore the sensitivity to new physics of the recently proposed vIOLETA experiment: a 10 kg Skipper Charged Coupled Device detector deployed 12 meters away from a commercial nuclear reactor core. We investigate two broad classes of models which benefit from the very low energy recoil threshold of these detectors, namely neutrino magnetic moments and light mediators coupled to neutrinos and quarks or electrons. We find that this experimental setup is very sensitive to light, weakly coupled new physics, and in particular that it could probe potential explanations of the event excess observed in XENON1T. We also provide a detailed study on the dependence of the sensitivity on the experimental setup assumptions and on the neutrino flux systematic uncertainties., Comment: 17 pages, 7 figures
- Published
- 2021
- Full Text
- View/download PDF
231. Titanium mesh for guided bone regeneration: a systematic review
- Author
-
Mateo-Sidrón Antón, M.C., Pérez-González, F., and Meniz-García, C.
- Published
- 2024
- Full Text
- View/download PDF
232. Molecular dynamics of structural effects of reactive carbonyl species derivate of lipid peroxidation on bovine serum albumin
- Author
-
Pineda-Alemán, Rafael, Cabarcas-Herrera, Camila, Alviz-Amador, Antistio, Galindo-Murillo, Rodrigo, Pérez-Gonzalez, Humberto, Rodríguez-Cavallo, Erika, and Méndez-Cuadro, Darío
- Published
- 2024
- Full Text
- View/download PDF
233. Influencia de la linfopenia en la mortalidad a largo plazo en shock séptico, estudio observacional retrospectivo
- Author
-
Rico-Feijoó, J., Bermejo-Martín, J.F., Pérez-González, A., Martín-Alfonso, S., and Aldecoa, C.
- Published
- 2024
- Full Text
- View/download PDF
234. Influence of lymphopenia on long-term mortality in septic shock, a retrospective observational study
- Author
-
Rico-Feijoó, J., Bermejo, J.F., Pérez-González, A., Martín-Alfonso, S., and Aldecoa, C.
- Published
- 2024
- Full Text
- View/download PDF
235. Deep learning identification of anthropogenic modifications on a carnivore remain suggests use of hyena pelts by Neanderthals in the Navalmaíllo rock shelter (Pinilla del Valle, Spain)
- Author
-
Moclán, Abel, Domínguez-Rodrigo, Manuel, Huguet, Rosa, Pizarro-Monzo, Marcos, Arsuaga, Juan Luis, Pérez-González, Alfredo, and Baquedano, Enrique
- Published
- 2024
- Full Text
- View/download PDF
236. Under the hood: Phylogenomics of hooded tick spiders (Arachnida, Ricinulei) uncovers discordance between morphology and molecules
- Author
-
Sato, Shoyo, Derkarabetian, Shahan, Valdez-Mondragón, Alejandro, Pérez-González, Abel, Benavides, Ligia R., Daniels, Savel R., and Giribet, Gonzalo
- Published
- 2024
- Full Text
- View/download PDF
237. Synthesis via microwave irradiation, structural characterization, and antibacterial activities of new complexes of bismuth(III) with thiosemicarbazones
- Author
-
Beltrán-Torres, Melissa, Santacruz-Ortega, Hisila, López-Gastelum, Karla A., Acosta-Elías, Mónica, Velázquez-Contreras, Enrique F., Aguirre-Hernández, Gerardo, Hernández-Paredes, Javier, Pérez-González, Refugio, Rocha-Alonzo, Fernando, García-Galaz, Alfonso, and Sugich-Miranda, Rocío
- Published
- 2024
- Full Text
- View/download PDF
238. Ongoing harlequin toad declines suggest the amphibian extinction crisis is still an emergency
- Author
-
Lötters, Stefan, Plewnia, Amadeus, Catenazzi, Alessandro, Neam, Kelsey, Acosta-Galvis, Andrés R., Alarcon Vela, Yesenia, Allen, Joshua P., Alfaro Segundo, Juan O., de Lourdes Almendáriz Cabezas, Ana, Alvarado Barboza, Gilbert, Alves-Silva, Kleiton R., Anganoy-Criollo, Marvin, Arbeláez Ortiz, Ernesto, Arpi Lojano, Jackeline D., Arteaga, Alejandro, Ballestas, Onil, Barrera Moscoso, Diego, Barros-Castañeda, José D., Batista, Abel, Bernal, Manuel H., Betancourt, Esteban, da Cunha Bitar, Youszef Oliveira, Böning, Philipp, Bravo-Valencia, Laura, Cáceres Andrade, José F., Cadenas, Diego, Chaparro Auza, Juan Carlos, Chaves-Portilla, Giovanni A., Chávez, Germán, Coloma, Luis A., Cortez-Fernandez, Claudia F., Courtois, Elodie A., Culebras, Jaime, De la Riva, Ignacio, Diaz, Vladimir, Elizondo Lara, Luis C., Ernst, Raffael, Flechas, Sandra V., Foch, Thibaut, Fouquet, Antoine, García Méndez, Carmen Z., García-Pérez, Juan Elias, Gómez-Hoyos, Diego A., Gomides, Samuel C., Guerrel, Jorge, Gratwicke, Brian, Guayasamin, Juan M., Griffith, Edgardo, Herrera-Alva, Valia, Ibáñez, Roberto, Idrovo, Carlos Iván, Jiménez Monge, Andrés, Jorge, Rafael F., Jung, Alisha, Klocke, Blake, Lampo, Margarita, Lehr, Edgar, Lewis, Carrie H. R., Lindquist, Erik D., López-Perilla, Yeny R., Mazepa, Glib, Medina-Rangel, Guido F., Merino Viteri, Andrés, Mulder, Kevin, Pacheco-Suarez, Mauricio, Pereira-Muñoz, Andry, Pérez-González, José Luis, Pinto Erazo, Maria Alejandra, Pisso Florez, Adolfo Gustavo, Ponce, Marcos, Poole, Vicky, Quezada Riera, Amanda B., Quiroz, Aarón J., Quiroz-Espinoza, Michelle, Ramírez Guerra, Alejandro, Ramírez, Juan P., Reichle, Steffen, Reizine, Hugo, Rivera-Correa, Mauricio, Roca-Rey Ross, Bernardo, Rocha-Usuga, Andrés, Rodrigues, Miguel Trefaut, Rojas Montaño, Sintana, Rößler, Daniela C., Rueda Solano, Luis Alberto, Señaris, Celsa, Shepack, Alexander, Siavichay Pesántez, Fausto R., Sorokin, Anton, Terán-Valdez, Andrea, Torres-Ccasani, Grecia, Tovar-Siso, Pablo C., Valencia, Lina M., Velásquez-Trujillo, David A., Veith, Michael, Venegas, Pablo J., Villalba-Fuentes, Jeferson, von May, Rudolf, Webster Bernal, Juan F., and La Marca, Enrique
- Published
- 2023
- Full Text
- View/download PDF
239. Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction
- Author
-
Barbazan, Jorge, Pérez-González, Carlos, Gómez-González, Manuel, Dedenon, Mathieu, Richon, Sophie, Latorre, Ernest, Serra, Marco, Mariani, Pascale, Descroix, Stéphanie, Sens, Pierre, Trepat, Xavier, and Vignjevic, Danijela Matic
- Published
- 2023
- Full Text
- View/download PDF
240. Novelty detection in an auditory oddball task on freely moving rats
- Author
-
Quintela-Vega, Laura, Morado-Díaz, Camilo J., Terreros, Gonzalo, Sánchez, Jazmín S., Pérez-González, David, and Malmierca, Manuel S.
- Published
- 2023
- Full Text
- View/download PDF
241. Correction to: Interpreting finite element results for brittle materials in endodontic restorations
- Author
-
Pérez-González, Antonio, Iserte-Vilar, José L, and González-Lluch, Carmen
- Published
- 2023
- Full Text
- View/download PDF
242. Organic geochemical evidence of human-controlled fires at Acheulean site of Valdocarros II (Spain, 245 kya)
- Author
-
Stancampiano, Lavinia M., Rubio-Jara, Susana, Panera, Joaquín, Uribelarrea, David, Pérez-González, Alfredo, and Magill, Clayton R.
- Published
- 2023
- Full Text
- View/download PDF
243. Evolution and long‑term respiratory sequelae after severe COVID-19 pneumonia: nitric oxide diffusion measurement value
- Author
-
Núñez-Fernández, Marta, Ramos-Hernández, Cristina, García-Río, Francisco, Pérez-González, Alexandre, Tilve-Gómez, Amara, Rodríguez-Fernández, Paula, Nodar-Germiñas, Andrés, Fernández-García, Alberto, Ruano-Raviña, Alberto, and Fernández-Villar, Alberto
- Published
- 2023
- Full Text
- View/download PDF
244. Status and perspectives of blue economy sectors across the Macaronesian archipelagos
- Author
-
Fernández-Palacios, Yaiza, Kaushik, Sadasivam, Abramic, Andrej, Cordero-Penín, Víctor, García-Mendoza, Alejandro, Bilbao-Sieyro, Alberto, Pérez-González, Yeray, Sepúlveda, Pedro, Lopes, Isabel, Andrade, Carlos, Nogueira, Natacha, Carreira, Gilberto P., Magalhães, Maria, and Haroun, Ricardo
- Published
- 2023
- Full Text
- View/download PDF
245. Un acercamiento necesario a la formación de conceptos matemáticos
- Author
-
Neisy Caridad Rodríguez Morales, Andel Pérez González, and Ortelio Nilo Quero Méndez
- Subjects
conceptos ,desarrollo del pensamiento ,formación de conceptos ,matemática y proceso de enseñanza-aprendizaje. ,Education (General) ,L7-991 ,Special aspects of education ,LC8-6691 - Abstract
Los conocimientos matemáticos se fundamentan y amplían a partir de los conceptos y de sus relaciones con diversas situaciones de la vida práctica; de ahí, la pertinencia de aprovechar las potencialidades de su tratamiento didáctico para la formación integral de los estudiantes desde el proceso de enseñanza-aprendizaje de la Matemática. En consecuencia, el proceso de formación de conceptos se reconoce como una vía fundamental para el desarrollo del pensamiento y, a al análisis de este, se le concede especial importancia en la Didáctica de la Matemática. Es por ello que, este artículo tiene como objetivo exponer los fundamentos, las regularidades didácticas y las exigencias actuales a considerar durante el proceso de formación de conceptos matemáticos. Para su realización se utilizaron métodos teóricos y empíricos; de los primeros se usaron: el histórico-lógico, el analítico-sintético y el inductivo-deductivo, con el fin de hacer generalizaciones en torno a la temática y de los segundos: el análisis documental, para interpretar las aspiraciones y exigencias metodológicas de los documentos rectores vigentes. Su principal resultado lo constituyen las ideas teóricas y metodológicas que se derivaron de la revisión bibliográfica realizada, las cuáles deben guiar el proceso de formación de conceptos matemáticos en la práctica pedagógica.
- Published
- 2024
246. Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys
- Author
-
Yumei Gong, Peirun Song, Xinyu Du, Yuying Zhai, Haoxuan Xu, Hangting Ye, Xuehui Bao, Qianyue Huang, Zhiyi Tu, Pei Chen, Xuan Zhao, David Pérez-González, Manuel S. Malmierca, and Xiongjie Yu
- Subjects
CP: Neuroscience ,Biology (General) ,QH301-705.5 - Abstract
Summary: The neural mechanisms underlying novelty detection are not well understood, especially in relation to behavior. Here, we present single-unit responses from the primary auditory cortex (A1) from two monkeys trained to detect deviant tones amid repetitive ones. Results show that monkeys can detect deviant sounds, and there is a strong correlation between late neuronal responses (250–350 ms after deviant onset) and the monkeys’ perceptual decisions. The magnitude and timing of both neuronal and behavioral responses are increased by larger frequency differences between the deviant and standard tones and by increasing the number of standard tones preceding the deviant. This suggests that A1 neurons encode novelty detection in behaving monkeys, influenced by stimulus relevance and expectations. This study provides evidence supporting aspects of predictive coding in the sensory cortex.
- Published
- 2024
- Full Text
- View/download PDF
247. Crecimiento alométrico de Panulirus gracilis (DECAPODA: PALINURA) asociado a la fase de madurez gonádica
- Author
-
Jennifer Zoe Borrego-Durán, Raúl Pérez-González, Guillermo Rodríguez-Domínguez, Martin Ignacio-Borrego, José Adán Félix-Ortiz, Juan Francisco Arzola-González, Yecenia Gutiérrez-Rubio, and Jorge Payán-Alejo
- Subjects
Langosta ,alometría ,madurez ,selección multimodelo ,Agriculture - Abstract
Se analizó el crecimiento relativo de langosta espinosa Panulirus gracilis, con un enfoque de selección multimodelo y la teoría de la información de Akaike. Se realizaron muestreos en capturas comerciales de langosta espinosa del sur de Sinaloa, México entre las temporadas de pesca de 2014 y 2015 y, 2017 y 2018. En 298 hembras de P. gracilis se registró la longitud cefalotórax (LC) mm, peso total (PT) g y fase de madurez gonádica. La estructura de tallas varió de 54.6 a 103.1 mm de LC. Se observaron hembras maduras a partir de 57.5 mm de LC, con un incremento de proporción de madurez en tallas mayores. El mejor modelo fue Línea Rota (Wi=65.09%) y Dos Segmentos (Wi%=34.87). El cambio en el crecimiento relativo a la talla en ambos modelos, coincidió con un incremento en la proporción de madurez en tallas mayores a 60 mm de LC en P. gracilis.
- Published
- 2024
- Full Text
- View/download PDF
248. Actionable mutational profiling in solid tumors using hybrid‐capture‐based next‐generation sequencing in a real‐world setting in Spain
- Author
-
Sandra Zazo, Sandra Pérez‐Buira, Nerea Carvajal, Jenifer Plaza‐Sánchez, Rebeca Manso, Nuria Pérez‐González, Carolina Dominguez, Iván Prieto‐Potin, Jaime Rubio, Manuel Dómine, Virginia Lozano, Patricia Mohedano, David Carcedo, Rafael Carias, and Federico Rojo
- Subjects
actionable mutation ,lung cancer ,molecular alterations ,next‐generation sequencing ,solid tumor ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Objective This study aimed to describe the performance of a next‐generation sequencing (NGS) panel for the detection of precise genomic alterations in cancer in Spanish clinical practice. The impact of tumor characteristics was evaluated on informative NGS and actionable mutation rates. Materials and Methods A cross‐sectional study was conducted at the Fundación Jiménez Díaz University Hospital (May 2021–March 2022) where molecular diagnostic of 537 Formalin‐Fixed Paraffin‐Embedded (FFPE) tissue samples of diverse solid tumors (lung, colorectal, melanoma, gastrointestinal stromal, among others) was performed using AVENIO Tumor Tissue Targeted Kit. A descriptive analysis of the features of all samples was carried out. Multivariable logistic analysis was conducted to assess the impact of sample characteristics on NGS performance defined by informative results rate (for all tumors and for lung tumors), and on actionable mutations rate (for lung tumors only). Results AVENIO performance rate was 75.2% in all tumor samples and 75.3% in lung cancer samples, and the multivariable analysis showed that surgical specimens are most likely to provide informative results than diagnostic biopsies. Regarding the mutational findings, 727 pathogenic, likely pathogenic, or variant of unknown significance mutations were found in all tumor samples. Single nucleotide variant was the most common genomic alteration, both for all tumor samples (85.3% and 81.9% for all solid tumors and lung samples, respectively). In lung tumors, multivariable analysis showed that it is more likely to find actionable mutations from non‐smokers and patients with adenocarcinoma, large cell, or undifferentiated histologies. Conclusion This is the largest cohort‐level study in Spain to profile the analyses of biopsy samples of different tumors using NGS in routine clinical practice. Our findings showed that the use of NGS routinely provides good rates of informative results and can improve tumor characterization and identify a greater number of actionable mutations.
- Published
- 2024
- Full Text
- View/download PDF
249. DESAFÍOS DE LA IMPLEMENTACIÓN DE LA INTELIGENCIA ARTIFICIAL EN SANIDAD: UN ANÁLISIS FILOSÓFICO JURÍDICO
- Author
-
David Enrique Pérez González
- Subjects
Inteligencia Artificial, Filosofía del Derecho, sanidad, ética. ,Law - Abstract
La irremediable conexión existente entre la Inteligencia Artificial con el ámbito sanitario provoca que se planteen cuestiones éticas cruciales que requieren un examen con profundidad y una reinterpretación de los valores éticos vigentes hasta hoy en día. Sobre esta base la Filosofía del Derecho se preocupa por defender que la equidad y la justicia sean dogma de fe. Estas situaciones controvertidas se ven reflejadas también en el campo de la sanidad, ya que presentan diferentes materias a resolver sobre la aplicación de la Inteligencia Artificial en el ámbito sanitario desde la perspectiva de la Filosofía del Derecho, tema que va a centrar el núcleo de la investigación de este trabajo. Al respecto aseverar que la Inteligencia Artificial ha tenido un impacto significativo en el campo de la sanidad y la atención sanitaria en diversas áreas de la medicina, pero al mismo tiempo plantea importantes cuestiones éticas que deben ser consideradas cuidadosamente para su adecuada aplicación. En definitiva, la introducción de la Inteligencia Artificial con una reflexión filosófico jurídica plantea numerosos desafíos y suficientes razones para trazar una ruta de análisis sobre la naturaleza del derecho, la ética, la justicia y la responsabilidad de los profesionales en el ámbito sanitario. Los filósofos del derecho están explorando activamente estas cuestiones a medida que la Inteligencia Artificial continúa transformando la forma en que interactúa el sistema legal con los avances tecnológicos desde una perspectiva ética.
- Published
- 2024
250. Nitrogenase cofactor biosynthesis using proteins produced in mitochondria of Saccharomyces cerevisiae
- Author
-
Katarzyna Dobrzyńska, Ana Pérez-González, Carlos Echavarri-Erasun, Diana Coroian, Alvaro Salinero-Lanzarote, Marcel Veldhuizen, Dennis R. Dean, Stefan Burén, and Luis M. Rubio
- Subjects
NifEN ,FeMo-co biosynthesis ,mitochondria ,nitrogen fixation ,pathway engineering ,yeast ,Microbiology ,QR1-502 - Abstract
ABSTRACT Biological nitrogen fixation, the conversion of inert N2 to metabolically tractable NH3, is only performed by certain microorganisms called diazotrophs and is catalyzed by the nitrogenases. A [7Fe-9S-C-Mo-R-homocitrate]-cofactor, designated FeMo-co, provides the catalytic site for N2 reduction in the Mo-dependent nitrogenase. Thus, achieving FeMo-co formation in model eukaryotic organisms, such as Saccharomyces cerevisiae, represents an important milestone toward endowing them with a capacity for Mo-dependent biological nitrogen fixation. A central player in FeMo-co assembly is the scaffold protein NifEN upon which processing of NifB-co, an [8Fe-9S-C] precursor produced by NifB, occurs. Prior work established that NifB-co can be produced in S. cerevisiae mitochondria. In the present work, a library of nifEN genes from diverse diazotrophs was expressed in S. cerevisiae, targeted to mitochondria, and surveyed for their ability to produce soluble NifEN protein complexes. Many such NifEN variants supported FeMo-co formation when heterologously produced in the diazotroph A. vinelandii. However, only three of them accumulated in soluble forms in mitochondria of aerobically cultured S. cerevisiae. Of these, two variants were active in the in vitro FeMo-co synthesis assay. NifEN, NifB, and NifH proteins from different species, all of them produced in and purified from S. cerevisiae mitochondria, were combined to establish successful FeMo-co biosynthetic pathways. These findings demonstrate that combining diverse interspecies nitrogenase FeMo-co assembly components could be an effective and, perhaps, the only approach to achieve and optimize nitrogen fixation in a eukaryotic organism.IMPORTANCEBiological nitrogen fixation, the conversion of inert N2 to metabolically usable NH3, is a process exclusive to diazotrophic microorganisms and relies on the activity of nitrogenases. The assembly of the nitrogenase [7Fe-9S-C-Mo-R-homocitrate]-cofactor (FeMo-co) in a eukaryotic cell is a pivotal milestone that will pave the way to engineer cereals with nitrogen fixing capabilities and therefore independent of nitrogen fertilizers. In this study, we identified NifEN protein complexes that were functional in the model eukaryotic organism Saccharomyces cerevisiae. NifEN is an essential component of the FeMo-co biosynthesis pathway. Furthermore, the FeMo-co biosynthetic pathway was recapitulated in vitro using only proteins expressed in S. cerevisiae. FeMo-co biosynthesis was achieved by combining nitrogenase FeMo-co assembly components from different species, a promising strategy to engineer nitrogen fixation in eukaryotic organisms.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.