224 results on '"P Hekmati"'
Search Results
202. Mechanical Properties of PA-6 Electrospun Nanoweb.
- Author
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Hekmati, Amir Houshang, Khenoussi, Nabyl, Drean, Jean-Yves, Adolphe, Dominique, and Schacher, Laurence
- Abstract
The mechanical properties of PA-6 electrospun nanowebs were studied in this research. PA-6 pellets were dissolved in formic acid to yield 25 wt.% solution. To ensure the reproducibility of electrospinning process, all important parameters have been studied and the optimum of electrospinning conditions was obtained. Electrospun nanowebs were removed from the aluminum foil (collector) using a simple method without any physical damage. SEM and AFM devices were used to precisely observe the nanowebs longitudinal and cross-sectional morphology. All samples were cut in same dimension (5×15 mm) and weighted by a mechanical micro-balance to get the weight per surface unit of nanowebs. Samples were put in the special supports which were built by cardboard layers to do the tensile tests by MTS tensile testing machine. The results of this work show the relationship between weight per surface unit of PA-6 nanowebs and their tensile strength and modulus. [ABSTRACT FROM AUTHOR]
- Published
- 2010
203. Morphological and Mechanical Characterization of PA-6 Nano-webs.
- Author
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Hekmati, Amir Houshang, Khenoussi, Nabyl, Schacher, Laurence, Adolphe, Dominique, Drean, Jean-Yves, Rashidi, Abousaied, and Ghazisaiedi, Reza
- Abstract
In this study the morphological and mechanical properties of PA-6 electrospun nano-webs were investigated. Three concentrations (15, 20 and 25 wt%) of PA-6 were electrospun. SEM and AFM photos were taken to precisely observe the nanowebs longitudinal and cross-sectional morphology. To study the heating effect on the nano-webs, the PA-6 nano webs were heated in different temperatures. The deformations were investigated by the SEM photos. This work is an introduction to mechanical characterization of the nano-webs that will be done by our group in LPMT; in this perspective some results of the preliminary tests like UHNT to determine the elastic modulus are presented. [ABSTRACT FROM AUTHOR]
- Published
- 2009
204. Relation Between Macromolecular Configuration and Electrospinnability.
- Author
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Khenoussi, Nabyl, Hekmati, Amir Houshang, Schacher, Laurence, and Adolphe, Dominique
- Abstract
The electrospinning process is a way to produce nanofibers that can be used with a wide variety of polymers. Through a complex stretching effect generated by electrical charge, electrospinning transform a droplet of polymer into the nanofibers. In the process parameters, the rheological behaviours of the solution determine the spinnability. In the case of polymer solution, the macromolecular arrangement governs these behaviours. To precisely define the electrospinnability of the polymers, our researches have been focused on evaluation of the solution behaviour through rheological characterization. In this study, the two solutions, Polyacrylonitrile/Dimethylformamide and Polyamide-6 and Polyamide6-6/Formic acid have been rheologicaly tested. Through theses results it has been possible to link the mechanical requirements of the electrospinnability and the macromolecular configuration of the polymers chains. [ABSTRACT FROM AUTHOR]
- Published
- 2009
205. STUDY OF RHEOLOGICAL BEHAVIOUR OF POLYMER SOLUTION USED FOR ELECTROSPINNING PROCES.
- Author
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Nabyl, Khenoussi, Houshang, Hekmati Amir, Drean Emilie, Laurence, Schacher, and Dominique, Adolphe
- Abstract
The electrospinning process is a way to produce nanofibers that can be used with a wide variety of polymer. It consists in introducing a polymer solution into a high voltage field via a metallic needle. This solution is submitted to a high stretch effect which transforms droplet into nanofibers. To obtain nanofibers, it is important to control the process conditions. In the process parameters, the solution properties; in terms of viscosity is crucial to the spinnability. To precisely define the electrospinnability of the polymer, our researches have been focused on evaluation of the solution behavior through rheological characterization. In our studies, two solutions Polyacrylonitrile/Dimethylformamide and Polyamide/Formic acid have been rheologicaly tested, during the flow state for different concentrations. Thanks to these results, the electrospinability of each solution could be known as well as the physical and mechanical behavior of the resultant nanofibers. [ABSTRACT FROM AUTHOR]
- Published
- 2009
206. Anti-Myeloma Effects of the Selective JAK1 Inhibitor INCB052793 Using a Platform Study Utilizing the Lagκ-1A Multiple Myeloma Xenograft Model
- Author
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Sanchez, Eric, Li, Mingjie, Wang, Cathy S, Tanenbaum, Edward J, Patil, Saurabh, Soof, Camilia, Hekmati, Tara, Schlossberg, Remy E, Yashar, Moryel A, Porter, Autumn L, Tang, George Y, Chen, Haiming, and Berenson, James R
- Abstract
Introduction:We have previously shown that severe combined immune deficiency (SCID)mice bearing the human multiple myeloma (MM) LAGk-1A xenograft develop significantly smaller tumors when treated with the JAK1 inhibitor INCB052793 (INCB; Incyte, Wilmington, DE) alone. Additionally, mice receiving the doublets of this agent and dexamethasone (DEX), lenalidomide (LEN) or pomalidomide (POM) demonstrated enhanced anti-MM effects on LAGk-1A growth in vivothat was superior to the doublets of DEX with LEN or POM. Mice receiving the triple combination of INCB + DEX with LEN or POM demonstrated the most pronounced anti-MM effect on tumor growth in vivocompared to all other combinations tested. Herein, we evaluated the response and toxicity of animals treated in combination or sequentially with INCB as well as with LEN plus DEX. For example, is there enhanced anti-MM activity when INCB + LEN are administered first, and DEX is added after disease progression? Or is there enhanced anti-MM activity when INCB + LEN is administered first and then substituted with DEX? This same treatment strategy was evaluated with INCB + DEX administered first, followed by the various permutations of LEN. Additionally, given that in the clinical setting DEX plus LEN is commonly administered to patients with MM, we evaluated these combinations with the addition of INCB or substitution of one of these drugs with INCB. Similarly, we evaluated the anti-MM effects of mice progressing from DEX therapy and added in INCB, substituted DEX with INCB, continued DEX and added in INCB + LEN.
- Published
- 2017
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207. Effects of the Gamma Secretase Inhibitors (GSI) Dapt (GSI-IX) and LSN424354 on Gene Expression and Shedding of Bcma from Multiple Myeloma and Chronic Lymphocytic Leukemia Tumor Cells
- Author
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Chen, Haiming, Li, Mingjie, Sanchez, Eric, Soof, Camilia, Patil, Saurabh, Udd, Kyle, Zhou, Mizi, Hekmati, Tara, Wang, Emily Y, Tanenbaum, Edward J, Schlossberg, Remy, Yashar, Moryel A, Wang, Cathy S, Tang, George Y, and Berenson, James R
- Abstract
Introduction:Multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients have high levels of solubilized (s) BCMA in the blood, and this protein is responsible for the immune deficiency of MM. sBCMA may also interfere with the efficacy of anti-BCMA-CAR-transduced T cells or other anti-BCMA antibody-based immunotherapy for multiple myeloma patients. Recently, γ-secretase has been identified as the enzyme that leads to the shedding of BCMA from B-cells. Gamma secretase (GS) is a multi-subunit protease complex that includes four individual proteins: presenilin-1 (PSEN1), nicastrin, anterior pharynx-defective 1 (APH-1), and presenilin enhancer 2 (PEN-2). CD147 acts as a non-essential regulator of the complex. We examined gene expression of PSEN1, APH-1, PEN-2, and CD147 among MM pts with progressive disease (PD) and complete remission (CR). We also determined the effects of the GS inhibitors (i) DAPT (GSI-IX) and LSN424354 (Eli Lilly, Indianapolis, IN) on solubilized BCMA levels from cultured human MM and CLL tumor cells.
- Published
- 2017
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208. Serum Bcma May Interfere with Anti-Bcma-CAR-Transduced T Cells or Other Anti-Bcma Antibody-Based Immunotherapy in Multiple Myeloma
- Author
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Chen, Haiming, Li, Mingjie, Sanchez, Eric, Soof, Camilia, Patil, Saurabh, Udd, Kyle, Zhou, Mizi, Hekmati, Tara, Wang, Emily Y, Tanenbaum, Edward J, Schlossberg, Remy, Yashar, Moryel A, Wang, Cathy S, Tang, George Y, and Berenson, James R
- Abstract
Introduction:CAR T cell-based immunotherapy has shown clinical activity in a variety of B-cell malignancies. Specifically, the engineered CAR-transduced T cells targeting B-cell maturation antigen (BCMA) on multiple myeloma (MM) have shown promising activity for the treatment of relapsed/refractory (RR) MM patients. However, MM patients have high levels of solubilized BCMA (sBCMA) in the blood especially those with RR disease. Due to these findings, we hypothesized that circulating levels of sBCMA may interfere with the efficacy of CAR T cell immunotherapy or other anti-BCMA antibody (Ab)-based therapeutic approaches for treating MM patients.
- Published
- 2017
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209. Gene Expression of Gamma Secretase (GS) Complex-Related Proteins, the Enzyme That Sheds B-Cell Maturation Antigen (BCMA), Among Patients with Multiple Myeloma (MM) and Effects of the GS Inhibitor LSN424354 on Solubilized Bcma in MM and Chronic Lymphocytic Leukemia
- Author
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Chen, Haiming, Li, Mingjie, Sanchez, Eric, Wang, Cathy S, Udd, Kyle A, Soof, Camilia M, Casas, Christian E, Wang, Jessica, Cao, Jasmin, DeCorso, Kevin, Hekmati, Tara, Tang, George, and Berenson, James R.
- Abstract
Berenson: OncoTracker: Employment, Equity Ownership.
- Published
- 2016
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210. Determination of voiding pressure in infants with normal lower urinary tracts: Exploring the possible effect of sacral development.
- Author
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Zahir M, Ladi-Seyedian SS, Majidi Zolbin M, Sharifi-Rad L, Hekmati P, and Kajbafzadeh AM
- Subjects
- Humans, Retrospective Studies, Female, Male, Infant, Urinary Bladder physiopathology, Urinary Bladder diagnostic imaging, Ureteral Obstruction physiopathology, Ureteral Obstruction diagnostic imaging, Sacrum diagnostic imaging, Urodynamics, Pressure, Urination physiology
- Abstract
Objective: To investigate the association between sacral underdevelopment, as defined by subnormal sacral ratio (SR) measurements, with increased maximum detrusor voiding pressure (P det. Max) in infants., Methods: In this 2007-2015 retrospective cohort study, the medical records of all infants who underwent a pyeloplasty due to congenital ureteropelvic junction obstruction were added. Their P det. Max was evaluated through the suprapubic catheter utilized for urinary drainage intraoperatively, without imposing any additional risk of urethral catheterization on the infant. SR was calculated via the plain kidney, ureter, and bladder (KUB) radiography film obtained during the voiding cystourethrogram (VCUG) evaluation before the surgery. Participants were categorized into SR < 0.74 or SR ≥ 0.74. P det. Max was subsequently compared between these two groups., Results: A total of 45 patients were included in our analysis. Twenty-eight (62.2%) patients had a (SR < 0.74), while 17 (37.8%) had a (SR ≥ 0.74). P det. Max was shown to be significantly higher in the SR < 0.74 compared to the SR ≥ 0.74 group (167.5 ± 60.8 vs. 55.7 ± 17.9 cmH
2 O, p < 0.001). After adjusting for age and sex, SR remained a significant contributor to P det. Max (p < 0.001). Physiologic detrusor sphincter dyscoordination (PDSD) rate was significantly higher in the SR < 0.74 versus SR ≥ 0.74 group (100.0% vs. 70.6%, respectively; p = 0.005)., Conclusion: Lumbosacral underdevelopment, as indicated by subnormal sacral ratios, is associated with sphincter-detrusor dyscoordination, which causes PDSD and can ultimately result in higher P det. Max in infants., (© 2024 Wiley Periodicals LLC.)- Published
- 2024
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211. Three rare etiologies of urinary retention in pediatrics: A case series and review of the literature.
- Author
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Hekmati P, Arshadi H, Kamran H, Kajbafzadeh AM, Zahir M, Amirzargar H, and Ghahestani SM
- Abstract
Etiology of urinary retention in pediatric age differs significantly from adults and the elderly. Therefore, a comprehensive diagnosis is crucial before specific treatment. Every effort must be made to minimize invasive procedures as far as possible in children., Competing Interests: The authors declare that they have no competing interests., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
- Published
- 2023
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212. Current status and future perspectives of wilms tumor treatment in Iran.
- Author
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Zahir M, Alidousti A, Kajbafzadeh AM, Arshadi H, Kompani F, Hajivalizadeh S, Zolbin MM, Ghohestani SM, Amirzargar H, and Hekmati P
- Abstract
Wilms tumor (WT) is among the most common pediatric malignancies. In this study, the authors tried to evaluate the adherence to internationally-approved WT treatment protocols in our tertiary medical center in Iran., Methods: In this retrospective study, the medical records of 72 pathologically confirmed WT patients who underwent treatment from April 2014 to February 2020 were evaluated. Demographic characteristics, histologic features of the tumors and metastases, utilized treatments, and survival rates were subsequently investigated., Results: From the total of 72 patients, 31 (43.1%) and 41 (56.9%) were males and females, respectively. The median age at the time of diagnosis was 44.0 (interquartile range: 18.5, 72.0) months. Among the patients, favorable histology was observed in 68 (94.6%) patients, while 4 (5.4%) patients had unfavorable histology. Regarding chemotherapy, 34/56 (60.7%), 4/56 (7.1%), and 18/56 (32.2%) received adjuvant, neoadjuvant, and combined chemotherapy, respectively. The mean numbers of neoadjuvant and adjuvant chemotherapy sessions were 9.4±5.6 and 14.5±11.1, respectively. 32/72 (44.4%) of the patients received adjuvant radiotherapy with a mean number of 7.3±3.6 sessions. Overall survival rates were 86% at 1-year, 74% at 3-year, and 62% at 5-year., Conclusion: Our results suggested that while the demographic characteristics of WT patients in Iran resemble those in other countries, abidance to internationally recommended protocols is relatively low. Moreover, survival rates were rather dismal in our study compared to those from other developing countries, further signifying the need for the development of a nation-specific treatment protocol for WT., Competing Interests: The authors have no conflict of interest to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2023
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213. Risk Factors Associated with Chronic Kidney Disease in Infants With Posterior Urethral Valve: A Single Center Study of 110 Patients Managed By Valve Ablation And Bladder Neck Incision.
- Author
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Amirzargar H, Shahab E, Ghahestani S, Hekmati P, and Arshadi H
- Subjects
- Adolescent, Follow-Up Studies, Humans, Infant, Male, Retrospective Studies, Risk Factors, Urethra surgery, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic epidemiology, Urinary Bladder diagnostic imaging, Urinary Bladder surgery
- Abstract
Purpose: Concurrent valve ablation and bladder neck incision is suggested as an effective and safe treatment approach in posterior urethral valve children with prominent bladder neck. We evaluated chronic kidney disease risk factors in these children., Materials and Methods: We retrospectively reviewed medical records of children with posterior urethral valve and included those younger than 18 years old who underwent valve ablation and bladder neck incision at our institution. We recorded patient demographics, presenting symptoms, laboratory and radiographic data. Our primary outcome was chronic kidney disease defined as stage 3 chronic kidney disease or higher. Renal outcome risk factors such as preoperative vesicoureteral reflux and serum creatinine, age at diagnosis, adjuvant urinary diversion were analyzed., Results: A total of 110 patients met our inclusion criteria. Median age at diagnosis was 10.4 months (range 14 days to 12 years). Prenatal diagnosis in 72.7% was the most common presentation. Mean follow-up duration was 3 years and 12(10.9%) patients progressed to chronic kidney disease. Preoperative serum creatinine greater than one mg/dL was the only factor associated with progression to chronic kidney disease., Conclusion: In our group of children with posterior urethral valve ablation and bladder neck incision, initial creatinine value of greater than one mg/dL is more probably associated with renal impairment while; vesicoureteral reflux, age at diagnosis, presenting symptoms and adjuvant urinary diversion were not significant prognostic factors. Further randomized controlled evaluations are required to analyze the effects of concurrent valve ablation and bladder neck incision on renal outcome.
- Published
- 2020
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214. A new technique of scrotoplasty following total scrotal destruction by raised rotated perineal flaps with de epithelialized borders.
- Author
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Ghahestani SM, Hekmati P, and Karimi S
- Subjects
- Child, Preschool, Humans, Male, Plastic Surgery Procedures methods, Urologic Surgical Procedures, Male methods, Fournier Gangrene surgery, Perineum surgery, Scrotum surgery, Surgical Flaps
- Abstract
In this article we present two-year-old male patient who had history of Fournier gangrene of scrotum. Extensive perineal and scrotal debridement with suprapubic cystostomy tube insertion had been done for him in the emergency setting One year later his parents brought him back for scrotal reconstruction. A novel technique by using rotational perineal flap was used.The cosmetic result of1 months and 3 months follow up is presented in the article.
- Published
- 2019
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215. Ovotesticular Disorder of Sex Development Presenting as an Acute Scrotum.
- Author
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Mirshahvalad SA, Alinia P, Hekmati P, Nafisi N, and Kajbafzadeh AM
- Subjects
- Acute Pain etiology, Adolescent, Diagnosis, Differential, Female, Humans, Male, Ovarian Follicle abnormalities, Ovotesticular Disorders of Sex Development complications, Ovotesticular Disorders of Sex Development surgery, Scrotum surgery, Seminiferous Tubules abnormalities, Acute Pain diagnosis, Ovarian Follicle surgery, Ovotesticular Disorders of Sex Development diagnosis, Scrotum physiopathology
- Abstract
Hermaphroditism is known as ovotesticular disorder of sex development. A 14-year-old boy was admitted with right acute scrotum. Exploration revealed tunica rupture and hematoma, with no viable tissue. After 1 month, he was admitted again with left hemiscrotal pain. Microscopic examination of the left gonad demonstrated foci of hemorrhagic cysts, primordial follicles, and regions of seminiferous tubules. We preserved a testicular tissue and the ovarian part was extracted completely. Long-term follow-up with his hormonal profile is reported. This is a case of ovotesticular disorder presented with acute scrotum and we also tried to reduce long-term hormone therapy, with preservation of testicular part., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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216. Use of baclofen in children with dysfunctional voiding: a preliminary report.
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Shirazi M, Jahnabadi Z, and Hekmati P
- Abstract
Introduction: The aims of the present study were to examine the effectiveness and safety of baclofen in children with dysfunctional voiding (DV)., Material and Methods: Thirty children with primary DV were enrolled. Patients underwent history taking, complete physical examination, urine analysis and culture, ultrasonography of the urinary system, a uroflowmetry study and post urine residue analysis. The Dysfunctional Voiding Symptom Score (DVSS) questionnaire was completed and other related symptoms were recorded. Oral baclofen was started for the study group at a dose of 1 mg/kg in 3 divided doses. Ultrasonography, a uroflowmetry study and questionnaire were repeated 3 months later., Results: We observed a mean decrease of 14.67 ml in post void residual urine (PVRU) after 3 months. After usage of baclofen, increase in Qmax (5.74), increase in mean flow rate (8.2 vs. 11.3), and an average decrease of 12.3 in the DVSS questionnaire (p <0.001) were also observed. The number of voluntary voiding and wetting episodes were significantly decreased after treatment with baclofen (p = 0.001). Three main complaints of the patients were urgency (p = 0.001), dysuria (p = 0.004) and straining (p = 0.004) and all were significantly decreased after medical therapy with baclofen., Conclusions: Baclofen may be useful in treatment of pediatric dysfunctional voiding. It was well tolerated among our patients with a remarkable reduction in their symptoms.
- Published
- 2018
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217. Scrotal Cooling to Protect Against Cisplatin-induced Spermatogenesis Toxicity: Preliminary Outcome of an Experimental Controlled Trial.
- Author
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Aminsharifi A, Hekmati P, Noorafshan A, Karbalay-Doost S, Nadimi E, Aryafar A, Hosseinabadi OK, Naseri MM, and ZarePoor M
- Subjects
- Animals, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C, Antineoplastic Agents toxicity, Cisplatin toxicity, Cold Temperature, Drug-Related Side Effects and Adverse Reactions prevention & control, Scrotum, Spermatogenesis drug effects
- Abstract
Objective: To investigate the protective effects of scrotal cooling on cisplatin-induced gonadal toxicity in an animal model., Methods: Twenty-one male BALB/c mice were divided into 3 groups. The cisplatin group received 2 cycles of cisplatin (2.5 mg/kg/day for 5 days with 16 days of recovery) intraperitoneally, and the cisplatin + cooling group received the same regimen of cisplatin with a cooling protocol: cooling induction for 30 minutes before injection and cooling for 60 minutes after injection. Mice in control group were given an injection of 2 mL normal saline intraperitoneally. After 35 days of recovery (1 cycle of spermatogenesis), the volume of the testes (Cavalieri method), volume density of the tubules and epithelium (point-counting method), and number of cells (optical dissector method) were estimated., Results: The volume of the testes, tubules, and epithelium was reduced between 61% and 66%, and the number of the spermatogonia, spermatocytes, round spermatids, and long spermatids was reduced between 70% and 93% in cisplatin group compared with that of control mice. Cisplatin affected spermatids to a greater extent, and Sertoli cells to a lesser extent than the other cells. The volume and number of the cells were reduced in the cisplatin + cooling group but to a lesser extent compared with those of mice in the cisplatin group. Sertoli cells were more intact in the cisplatin + cooling group compared with those of the control group., Conclusion: Scrotal cooling during cisplatin administration seems to have beneficial effects on spermatogenesis. Scrotal cooling may hold promise as a way to protect fertility., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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218. Nutcrackerlike Phenomenon Is An Unusual Cause for Gross Hematuria After a Kidney Graft.
- Author
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Salehipour M, Kazemi K, Shamsaeefar A, Hekmati P, Sanaei AK, Bahador A, Aliakbarian M, and Malek Hosseini SA
- Subjects
- Adult, Female, Humans, Kidney Failure, Chronic diagnosis, Renal Nutcracker Syndrome diagnosis, Renal Nutcracker Syndrome surgery, Reoperation, Time Factors, Treatment Outcome, Hematuria etiology, Kidney Failure, Chronic surgery, Kidney Transplantation adverse effects, Renal Nutcracker Syndrome etiology
- Abstract
Nutcracker phenomenon is the condition that occurs most commonly at the morphologic type by compression of the left renal vein between the aorta and superior mesenteric artery. The diagnosis is often delayed because of the variability in manifestations and absence of consensus on diagnostic criteria. We report a 30-year-old woman who presented gross hematuria several days after a kidney transplant. Nutcracker syndrome was established intraoperatively during open surgical approach for bladder clot evacuation. Renal repositioning was done with relief in the degree of hematuria intraoperatively. No episode of gross hematuria was observed on follow-up after 8 months.
- Published
- 2016
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219. Result of endoureterotomy in the management of primary obstructive megaureter in the first year of life: preliminary report.
- Author
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Shirazi M, Natami M, Hekmati P, and Farsiani M
- Subjects
- Female, Follow-Up Studies, Humans, Hydronephrosis, Infant, Male, Postoperative Complications, Stents, Ureter surgery, Urinary Tract Infections, Urologic Surgical Procedures instrumentation, Urologic Surgical Procedures methods, Ureteral Obstruction epidemiology, Ureteral Obstruction surgery, Urologic Surgical Procedures adverse effects
- Abstract
Purpose: The present study aimed to investigate the efficacy of endoureterotomy in patients who were less than 1-year-old with primary obstructive megaureter (POMU)., Patients and Methods: Three of 10 patients with POMU aged between 2 and 12 months for whom conservative management was not applicable had recurrent urinary tract infection (UTI) and urosepsis, while the rest had decreased renal function. After obtaining the clinical history and performing physical examinations and imaging studies (ultrasonography, voiding cystourethrography (VCUG), radionuclide renal scan), the patients underwent endoureterotomy using a neonatal ureteroscope (4.5F) and Bugbee electrode with pure cutting current at the 6 o'clock position. A Double-J stent was inserted and removed 1 week later. This was followed by serial physical examination, renal function test, urine analysis, urine culture, and imaging studies in the 1st month and every 3 months after Double-J stent removal., Results: Hydroureteronephrosis was significantly decreased in nine patients. Postoperative VCUG revealed no sign of iatrogenic vesicoureteral reflux. In addition, a follow-up renal scan showed remarkable improvement in the renal function in the patients who had decreased renal function, except for one patient in whom uncontrolled urosepsis developed in the follow-up; the patient underwent cutaneous ureterostomy. No UTI was detected in the group who presented with recurrent UTI and urosepsis., Conclusion: According to the results of our study, endoureterotomy may be an alternative in management of POMU. Of course, further studies with longer follow-up periods are needed to confirm the applicability of this method in patients younger than 1 year.
- Published
- 2014
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220. Use of autologous renal capsule grafts for venous repair.
- Author
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Hodjati H, Salehipour M, Safai A, Boveiri K, Hekmati P, Hadian P, and Tanideh N
- Subjects
- Animals, Dogs, Kidney anatomy & histology, Vascular Surgical Procedures methods, Kidney surgery, Tissue Transplantation, Vena Cava, Inferior surgery
- Abstract
Objective: To evaluate the efficacy of the renal capsule for reconstruction of the inferior vena cava in a canine model., Materials and Methods: The present study was conducted on 10 dogs; an oval window (2-8 cm long, mean 6.5 cm) was made in the inferior vena cava and then repaired using the autologous renal capsule patch. The patency and functionality of the graft were assessed macroscopically and microscopically 3 months postoperatively., Results: All the dogs were killed at 3 months, showing excellent patency of the vena cava macroscopically and in the venography. In the microscopic examination, all the patches were completely endothelialized. No evidence of infection or thrombosis was noted., Conclusion: A renal capsule patch can be used for reconstruction of the inferior vena cava. Patency appears to be good, and the risk of infection is low. Moreover, this is an accessible material., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
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221. Results of buccal mucosal graft urethroplasty in complex hypospadias.
- Author
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Irani D, Hekmati P, and Amin-Sharifi A
- Abstract
Introduction: Urethral reconstruction in complex hypospadias poses a significant challenge. We report our experience using buccal mucosa to repair complex hypospadias., Materials and Methods: From February 2001 to September 2003, 16 urethral reconstructions were performed using buccal mucosal graft. Twelve of the patients had previously failed urethroplasties, while the other 4 had perineal or scrotal hypospadias. Grafts were harvested from the lower lip. Onlay grafts were used in 8 cases, and tubularized grafts were used for the others., Results: After 14 to 27 months' follow-up, 11 of 16 (69%) patients developed complications, including meatal stenosis in 2 (12.5%), urethral stricture in 5 (31%), and urethrocutaneous fistula in 4 (25%). No oral complications were seen, and all of the urethroplasty complications were managed successfully., Conclusion: Urethroplasty using a buccal mucosal graft may be accompanied by a relatively high complication rate, which is more common in patients with tubularized graft; however, all complications can be managed successfully. We believe that urethroplasty using buccal mucosal graft in complex hypospadias is an acceptable treatment modality.
- Published
- 2005
222. Lamellar corneal transplantation in the horse.
- Author
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Hekmati P and Schels H
- Subjects
- Animals, Postoperative Care, Surgical Instruments veterinary, Suture Techniques veterinary, Transplantation, Heterologous, Transplantation, Homologous, Corneal Transplantation, Horses
- Abstract
Surgical correction of corneal opacities in horses has rarely been documented in detail and is still reported to be in the experimental stage. For this reason, studies of lamellar keratoplasty were conducted on the equine eye using a modified trephine with an adjustable inside quard for grafting of identical discs from the donor and the recipient cornea. Fourteen transplantations, seven with homografts and seven with heterografts, 15 and 9 mm in diameter, were performed. Sharp-edged, vertical, and regular outlined wound margins of the graft and host are essential for good adaptation and healing without tension. The details of instruments used, preoperative preparation, surgical technique, and postoperative care are described. Results indicated that this method is a feasible tool for the repair of corneal defects in the horse and may be usefully employed in an intention to restore vision.
- Published
- 1976
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223. Traumatic reticulitis, the comet naso-reticular instrument for withdrawal of foreign bodies from the reticulum of cattle.
- Author
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Hekmati P, Bakshodeh GA, and Dirch Poulsen JS
- Subjects
- Animals, Cattle, Female, Foreign Bodies complications, Foreign Bodies therapy, Inflammation etiology, Intubation, Gastrointestinal instrumentation, Magnetics, Cattle Diseases therapy, Foreign Bodies veterinary, Inflammation veterinary, Intubation, Gastrointestinal veterinary, Reticulum injuries
- Abstract
A new idea of a long-acting magnetic probe is presented and tested. The magnetic probe has been designed to remain for a period of time in the reticulum before it is retracted with the foreign bodies adhering to it. The instrument is fixed by a wire passing through the nose, pharynx and oesophagus. No adverse effects on the animal have been observed, and the animal can eat during the treatment. The examination showed that the instrument attracted nearly all the free foreign bodies and the superficially penetrating bodies, resulting in therapeutically good results in 50-55 per cent of the cases examined. The instrument has proved to be capable of attracting as many as 21 foreign bodies at the same time. As a preventive tool, it may be recommended to be used 2-3 times a year. Or it may be used for emptying the reticulum of foreign bodies prior to the application of a permanent magnet.
- Published
- 1985
224. Bursitis omentalis in cattle: three case reports.
- Author
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Hekmati P and Zakarian B
- Subjects
- Abomasum, Animals, Cattle, Female, Foreign Bodies complications, Foreign Bodies veterinary, Peptic Ulcer Perforation complications, Peptic Ulcer Perforation veterinary, Peritonitis drug therapy, Peritonitis etiology, Peritonitis surgery, Cattle Diseases, Omentum, Peritonitis veterinary
- Published
- 1971
- Full Text
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