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1,139 results on '"Park, Byung-Hyun"'

202. Issues and Policy Suggestions of Health Policy for Foreign Workers

Author

Park，Byung-Hyun, Choi Song Sik, Kim， Hyunsuk, and Kim Hee Jae

Subjects
Economic growth, medicine.medical_specialty, business.industry, Public health, International health, Health promotion, Political science, Occupational health nursing, medicine, Global health, Health law, Health education, business, Health policy
Published
2015

203. The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial

Author

Park, Soo-Hyun, primary, Jung, Su-Jin, additional, Choi, Eun-Kyung, additional, Ha, Ki-Chan, additional, Baek, Hyang-Im, additional, Park, Yu-Kyung, additional, Han, Kap-Hoon, additional, Jeong, Soon-Yeon, additional, Oh, Jung-Hee, additional, Cha, Youn-Soo, additional, Park, Byung-Hyun, additional, and Chae, Soo-Wan, additional

Published
2019
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205. Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis

Author

Yang, Ji Hye, primary, Kim, Kyu Min, additional, Cho, Sam Seok, additional, Shin, Sang Mi, additional, Ka, Sun O, additional, Na, Chang-Su, additional, Park, Byung Hyun, additional, Jegal, Kyung Hwan, additional, Kim, Jae Kwang, additional, Ku, Sae Kwang, additional, Lee, Hee-Jeong, additional, Park, Sang-Gon, additional, Cho, Il Je, additional, and Ki, Sung Hwan, additional

Published
2019
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212. SIRT6 Is Involved in the Progression of Ovarian Carcinomas via β-Catenin-Mediated Epithelial to Mesenchymal Transition

Author

Bae, Jun Sang, primary, Noh, Sang Jae, additional, Kim, Kyoung Min, additional, Park, See-Hyoung, additional, Hussein, Usama Khamis, additional, Park, Ho Sung, additional, Park, Byung-Hyun, additional, Ha, Sang Hoon, additional, Lee, Ho, additional, Chung, Myoung Ja, additional, Moon, Woo Sung, additional, Cho, Dong Hyu, additional, and Jang, Kyu Yun, additional

Published
2018
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217. Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR‐RANKL Signaling.

Author

Zhang, Zhongkai, Song, Yiping, Wang, Sung Il, Ha, Sang Hoon, Jang, Kyu Yun, Park, Byung‐Hyun, Moon, Young Jae, and Kim, Jung Ryul

Abstract

Ischemic osteonecrosis (ION) can produce permanent deformity and osteoarthritis in the femoral head and other joints. No biologic treatment has been established, and the molecular mechanisms involved in the pathogenesis of ION have not been elucidated. In this work, we found that treatment with sirtuin6 (Sirt6) suppressed inflammatory cytokines, bone resorption, progression of osteoarthritis, and reduced bone deformity in an ION mouse model. We used a deacetylase mutant adenovirus to confirm that those effects were caused by the deacetylase function of Sirt6. Among the osteoclastogenic factors of osteoblasts, only the receptor activator of NF‐κb ligand (RANKL) level changed in response to Sirt6 knockout in primary osteoblasts. In particular, the vitamin D receptor physically interacted with Sirt6 and induced recruitment of Sirt6 around RANKL promoters. Finally, Tg mice overexpressing Sirt6 resisted osteocyte death, bone resorption, and progression of osteoarthritis after ischemic surgery, whereas osteoblast/osteocyte‐specific Sirt6 knockout mice showed aggravated bone loss and severe deformity. Our findings demonstrate that administration of Sirt6 prevents bone loss and osteoarthritis in ischemic conditions. Activation of Sirt6 in osteoblasts/osteocytes could be a new therapeutic approach to treating ION of the femoral head and other bone regions. © 2020 American Society for Bone and Mineral Research (ASBMR). [ABSTRACT FROM AUTHOR]

Published
2021
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218. Simple Colorimetric and Fluorescence Chemosensing Probe for Selective Detection of Sn2+ Ions in an Aqueous Solution: Evaluation of the Novel Sensing Mechanism and Its Bioimaging Applications.

Author

Ravichandiran, Palanisamy, Kaliannagounder, Vignesh Krishnamoorthi, Bella, Antony Paulraj, Boguszewska-Czubara, Anna, Masłyk, Maciej, Kim, Cheol Sang, Park, Chan Hee, Johnson, Princy Merlin, Park, Byung-Hyun, Han, Myung-Kwan, Kim, Ae Rhan, and Yoo, Dong Jin

Published
2021
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228. Simple Colorimetric and Fluorescence Chemosensing Probe for Selective Detection of Sn2+Ions in an Aqueous Solution: Evaluation of the Novel Sensing Mechanism and Its Bioimaging Applications

Author

Ravichandiran, Palanisamy, Kaliannagounder, Vignesh Krishnamoorthi, Bella, Antony Paulraj, Boguszewska-Czubara, Anna, Masłyk, Maciej, Kim, Cheol Sang, Park, Chan Hee, Johnson, Princy Merlin, Park, Byung-Hyun, Han, Myung-Kwan, Kim, Ae Rhan, and Yoo, Dong Jin

Abstract

An easily accessible colorimetric and fluorescence probe 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide (4CBS) was successfully developed for the selective and sensitive detection of Sn2+in an aqueous solution. The sensing mechanism involves reduction of −C═O into −C–OH groups in 4CBSupon the addition of Sn2+, which initiates the fluorescence turn-on mode. A better linear relationship was achieved between fluorescence intensity and Sn2+concentration in the range of 0–62.5 μM, with a detection limit (LOD) of 0.115 μM. The binding mechanism of 4CBSfor Sn2+was confirmed by Fourier transform infrared analysis, NMR titrations, and mass (electrospray ionization) spectral analysis. Likewise, the proposed sensing mechanism was supported by quantum chemical calculations. Moreover, bioimaging studies demonstrated that the chemosensing probe 4CBSis an effective fluorescent marker for the detection of Sn2+in living cells and zebrafish. Significantly, 4CBSwas able to discriminate between Sn2+in human cancer cells and Sn2+in normal live cells.

Published
2021
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233. FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC

Author

Kim, Kyoung Min, primary, Park, See-Hyoung, additional, Bae, Jun Sang, additional, Noh, Sang Jae, additional, Tao, Guo-Zhong, additional, Kim, Jung Ryul, additional, Kwon, Keun Sang, additional, Park, Ho Sung, additional, Park, Byung-Hyun, additional, Lee, Ho, additional, Chung, Myoung Ja, additional, Moon, Woo Sung, additional, Sylvester, Karl G., additional, and Jang, Kyu Yun, additional

Published
2017
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240. Integration of reverse transcriptase loop-mediated isothermal amplification with an immunochromatographic strip on a centrifugal microdevice for influenza A virus identification

Author

Goro Choi, Bh Park Byung Hyun Park, Ts Seo Tae Seok Seo, Seung Jun Oh, and Jik-Han Jung

Subjects
Microfluidics, Biomedical Engineering, Loop-mediated isothermal amplification, Gene Expression, Bioengineering, Centrifugation, General Chemistry, Reverse Transcription, Biology, Amplicon, medicine.disease_cause, Biochemistry, Virology, Reverse transcriptase, Chromatography, Affinity, Influenza A Virus, H1N1 Subtype, Influenza A (H1N1) virus, Influenza A virus, medicine, Multiplex, Nucleic Acid Amplification Techniques
Abstract

A novel centrifugal microdevice which could perform reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) and immunochromatographic strip (ICS) based amplicon detection was demonstrated for simple and cost-effective influenza A virus identification. The proposed centrifugal microdevice consists of the sample and running buffer loading reservoirs, the RT-LAMP chamber, and the ICS for detecting gene expression. The entire process could be completed sequentially and automatically by simply controlling the rotation speed and by optimizing the microfluidic design. Monoplex and multiplex RT-LAMP reactions targeting H1 and/or M gene were executed at 66 °C for 40 min, and the resultant amplicons were successfully analysed on the ICS within 15 min. Influenza A H1N1 virus was subtyped by detecting H1 and M gene on the ICS even with 10 copies of viral RNAs. Highly specific and multiplex viral typing of the integrated RT-LAMP-ICS microdevice was also demonstrated. The combination of the rapid isothermal amplification with the simple colorimetric detection on a strip in a single centrifugal microdevice will provide an advanced genetic analysis platform in the field of on-site pathogen diagnostics.

Published
2014

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