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752 results on '"Plaza, Vicente"'

204. ¿Es útil la implantación de programas de gestión clínica de los pacientes con enfermedad pulmonar obstructiva crónica? Comparación de la efectividad de dos intervenciones sobre la evolución clínica y la atención recibida

Author

Solanes, Ingrid, primary, Bolíbar, Ignasi, additional, Llauger, Maria Antònia, additional, Peiro, Meritxell, additional, Valverde, Pepi, additional, Fraga, Mar, additional, Medrano, Casimira, additional, Bigorra, Teresa, additional, Freixas, Montserrat, additional, Ligüerre, Iskra, additional, Pou, Maria Antònia, additional, Domínguez, Leandra, additional, Valero, Carles, additional, Solà, Judit, additional, Giner, Jordi, additional, and Plaza, Vicente, additional

Published
2018
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205. Mixed Th2 and non-Th2 inflammatory pattern in the asthma–COPD overlap: a network approach

Author

Pérez de Llano, Luis, primary, Cosío, Borja G, additional, Iglesias, Amanda, additional, de las Cuevas, Natividad, additional, Soler-Cataluña, Juan Jose, additional, Izquierdo, Jose Luis, additional, López-Campos, Jose Luis, additional, Calero, Carmen, additional, Plaza, Vicente, additional, Miravitlles, Marc, additional, Torrego, Alfons, additional, Martinez‐Moragon, Eva, additional, Soriano, Joan B, additional, Lopez Viña, Antolin, additional, and Bobolea, Irina, additional

Published
2018
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206. Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease Patients with Frequent Hospitalized Exacerbations: A Prospective Multicentre Study

Author

Rodrigo-Troyano, Ana, primary, Melo, Valentina, additional, Marcos, Pedro J., additional, Laserna, Elena, additional, Peiro, Meritxell, additional, Suarez-Cuartin, Guillermo, additional, Perea, Lidia, additional, Feliu, Anna, additional, Plaza, Vicente, additional, Faverio, Paola, additional, Restrepo, Marcos I., additional, Anzueto, Antonio, additional, and Sibila, Oriol, additional

Published
2018
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207. Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood

Author

Crespo-Lessmann,Astrid, Mateus,Eder, Torrejón,Montserrat, Belda,Alicia, Giner,Jordi, Vidal,Silvia, Sibila,Oriol, Plaza,Vicente, Crespo-Lessmann,Astrid, Mateus,Eder, Torrejón,Montserrat, Belda,Alicia, Giner,Jordi, Vidal,Silvia, Sibila,Oriol, and Plaza,Vicente

Abstract

Astrid Crespo-Lessmann,1 Eder Mateus,1,2 Montserrat Torrejón,1 Alicia Belda,1 Jordi Giner,1 Silvia Vidal,2 Oriol Sibila,1 Vicente Plaza,1 1Service of Pneumology, Hospital de la Santa Ceu i Sant Pau, Institute of Sant Pau Biomedical Research (IBB Sant Pau), Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 2Department of Immunology, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomédica Sant Pau, Barcelona, Spain Abstract: Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). Objectives: 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion. Materials and methods: Cross-sectional study which included 43 non-smoking asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwent the following: IS, spirometry, fractional exhaled nitric oxide, prick test, total immunoglobulin E (IgE), and blood albumin. Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. The level of asthma control was determined by the Asthma Control Test (ACT) questionnaire and quality of life was assessed by the reduced version of the Asthma Quality of Life Questionnaire (mini-AQLQ). Results: Asthmatics with bronchial hypersecretion were significantly older (62.6 years vs 48.5 years; p=0.02); had greater severity (persistent severe asthma 94.7% vs 29.2%; p=0.000); a higher proportio

Published
2017

208. Motivational interviewing for adherence: post-training attitudes and perceptions of physicians who treat asthma patients

Author

Román-Rodríguez,Miguel, Ibarrola-Ruiz,Lara, Mora,Fernando, Plaza,Vicente, Sastre,Joaquín, Torrego,Alfonso, Vega,Jose Maria, Sanchez-Herrero,Guadalupe, Román-Rodríguez,Miguel, Ibarrola-Ruiz,Lara, Mora,Fernando, Plaza,Vicente, Sastre,Joaquín, Torrego,Alfonso, Vega,Jose Maria, and Sanchez-Herrero,Guadalupe

Abstract

Miguel Román-Rodríguez,1 Lara Ibarrola-Ruiz,2 Fernando Mora,3 Vicente Plaza,4 Joaquín Sastre,5 Alfonso Torrego,4 José María Vega6 Guadalupe Sánchez-Herrero2 1Centro de Salud Son Pisà, IB-Salut, Balearic Health Service, Unidad de investigación en enfermedades crónicas respiratorias en atención primaria, Instituto de Investigación Sanitaria de Baleares (IdISBa), Palma de Mallorca, 2GSK, 3Department of Psychiatry, Hospital Infanta Leonor, Madrid, 4Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomédica Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, 5Department of Allergology, Fundación Jimenez Díaz y Universidad Autónoma de Madrid, CIBER de Enfermedades Respiratorias, Ministerio de Economía y Competitividad, Madrid, 6Unidad de Gestión Clínica de Alergología, Hospital Regional Universitario de Málaga, Málaga, Spain Objective: The aim of this study was to evaluate the attitudes and perceptions of health care professionals (HCPs) who have been trained in motivational interviewing (MI) to improve adherence. Another objective of this study was to compare groups of HCPs with different levels of training in adherence (trained vs untrained; previous training in adherence education [AdhE] vs specific training in MI). Methods: For this study, a national questionnaire-based survey was conducted among HCPs treating asthma. A total of 360 HCPs were surveyed (allergists: n=110; pulmonologists: n=120; general practitioners: n=130). Of them, 180 physicians had received a training intervention (training in AdhE: n=90; training in MI to promote adherence: n=90). Results: Of the total surveyed HCPs, 92.8% reported adherence is highly important in asthma c

Published
2017

209. Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level

Author

Crespo Lessmann, Astrid, Mateus, Eder, Vidal, Silvia, Ramos-Barbón, David, Torrejón, Montserrat, Giner, Jordi, Soto, Lorena, Juarez, Candido, Plaza, Vicente, and Universitat Autònoma de Barcelona

Subjects
Male, Pulmonary and Respiratory Medicine, 0301 basic medicine, Allergy, Immunoglobulin E, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Immune system, Humans, Medicine, Asthma, Innate immunity, Innate immune system, biology, business.industry, Research, Sputum, Reproducibility of Results, Middle Aged, medicine.disease, Toll-Like Receptor 2, Toll-like receptors, Toll-Like Receptor 4, 030104 developmental biology, 030228 respiratory system, Immunology, Exhaled nitric oxide, biology.protein, TLR4, Female, IgE, medicine.symptom, business, Biomarkers
Abstract

Background: Emerging data suggest that innate immunity may play a role in asthma, particularly the toll-like receptors (TLRs). Some studies pointed to an involvement of TLRs 2 and 4 in the pathogenesis of allergic asthma, and other studies related TLRs to IgE. However, there are not any studies that have comprehensively evaluated the expression of TLRs 2 and 4 in inflammatory cells, in peripheral blood and induced sputum specimens from asthmatic patients, according to their total serum IgE. Methods: We studied 44 asthmatic patients (15 with high total serum IgE and 29 with normal total serum IgE). On a single visit, all patients underwent: induced sputum, pulmonary function tests, determination of exhaled nitric oxide fraction, venipuncture for blood analysis and skin prick allergy tests. The induced sputum cellularity was analyzed by flow cytometry, where expression of TLRs 2 and 4 was studied using fluorochrome-conjugated monoclonal antibodies. Results: Asthmatic patients with high total serum IgE showed, a higher percentage of macrophages expressing TLR4 (42.99 % +/- 22.49) versus asthmatic patients with normal total serum IgE (28.84 % +/- 15.16) (P = 0.048). Furthermore, we observed a correlation (but weak) between the percentage of macrophages expressing TLR4 in induced sputum and the total serum IgE level (R = 0.314; P = 0.040). Conclusion: Asthmatic subjects with high total serum IgE show increased macrophage expression of TLR4 in induced sputum. This outcome may result from a link between innate immunity and IgE-mediated, adaptive immune responses in asthma, and point to TLR4 as a potential therapeutic target.

Published
2016

212. The creation and long-term follow-up of a cohort of asthmatic patients. Baseline clinical characteristics of the study population: The MEGA Project

Author

Munoz, Xavier, primary, Arismendi, Ebymar, additional, Barranco, Pilar, additional, Cárdaba-Olombrada, Blanca, additional, Cruz Carmona, Mª Jesus, additional, del Pozo, Victoria, additional, Fernández-Nieto, María del Mar, additional, González-Barcala, Francisco-Javier, additional, Luna, Juan-Alberto, additional, Olaguibel, José-María, additional, Picado, Cesar, additional, Plaza, Vicente, additional, Quirce, Santiago, additional, Sastre, Joaquín, additional, Soto, Lorena, additional, Uriarte, Silvia, additional, Valero, Antonio, additional, and Vennera, María del carmen, additional

Published
2017
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213. Blood cytokine expression in patients with chronic obstructive airway diseases (COAD)

Author

Pérez De Llano, Luis, primary, Iglesias, Amanda, additional, Soler-Catalunya, Juan Jose, additional, Izquierdo, Jose Luis, additional, Plaza, Vicente, additional, Lopez Campos, Jose Luis, additional, Torrego, Alfons, additional, Martínez-Moragón, Eva, additional, Soriano, Joan, additional, Bobolea, Irina, additional, de las Cuevas, Natividad, additional, López-Viña, Antolin, additional, and G.Cosío, Borja, additional

Published
2017
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215. A simple score for future risk prediction in patients with controlled asthma who undergo a step-down guidelines-based strategy

Author

Pérez De Llano, Luis, primary, Carballada, Francisco, additional, García-Rivero, Juan Luis, additional, Urrutia, Isabel, additional, Martínez-Moragón, Eva, additional, Blanco, Marina, additional, Ramos, Jacinto, additional, Vennera, Maria del Carmen, additional, Plaza, Vicente, additional, Cebollero, Pilar, additional, and Merino, Maria, additional

Published
2017
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217. Periostin as a marker of Th2-related inflammation in patients with different types of chronic obstructive airway disease

Author

Pérez de Llano, Luis, primary, Garcia-Cosio Piqueras, Fco.De Borja, additional, Bobolea, Irina, additional, de las Cuevas, Natividad, additional, CHACOS study group, Separ, additional, LóPez-Campos, Jose Luis, additional, Plaza, Vicente, additional, Lopez-Viña, Antolin, additional, Torrego, Alfons, additional, Martinez Moragon, Eva, additional, Izquierdo, Jose Luis, additional, Callejas, Javier, additional, Soriano, Joan, additional, Miravitlles, Marc, additional, and Soler-Catalunya, Juan Jose, additional

Published
2017
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218. Hospital readmission increases short and long – term mortality in patients with interstitial lung disease after acute respiratory worsening

Author

Barril Farre, Silvia, primary, Rodrigo-Troyano, Ana, additional, Suárez-Cuartín, Guillermo, additional, Feliu, Anna, additional, Franquet, Tomás, additional, López-Vilaró, Laura, additional, Castellví, Iván, additional, Plaza, Vicente, additional, Sibila, Oriol, additional, and Castillo, Diego, additional

Published
2017
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219. Fibromyalgia as a cause of uncontrolled asthma: a case–control multicenter study

Author

Martinez-Moragon, Eva, primary, Plaza, Vicente, additional, Torres, Isabel, additional, Rosado, Ana, additional, Urrutia, Isabel, additional, Casas, Xavier, additional, Hinojosa, Belen, additional, Blanco-Aparicio, Marina, additional, Delgado, Julio, additional, Quirce, Santiago, additional, Sabadell, Carles, additional, Cebollero, Pilar, additional, and Muñoz-Fernández, Ana, additional

Published
2017
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222. Algorithm for identification of asthma–COPD overlap: consensus between the Spanish COPD and asthma guidelines

Author

Miravitlles, Marc, primary, Alvarez-Gutierrez, Francisco Javier, additional, Calle, Myriam, additional, Casanova, Ciro, additional, Cosio, Borja G., additional, López-Viña, Antolín, additional, Pérez de Llano, Luis, additional, Quirce, Santiago, additional, Roman-Rodríguez, Miguel, additional, Soler-Cataluña, Juan José, additional, and Plaza, Vicente, additional

Published
2017
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223. Th-2 signature in chronic airway diseases: towards the extinction of asthma−COPD overlap syndrome?

Author

Cosío, Borja G., primary, Pérez de Llano, Luis, additional, Lopez Viña, Antolin, additional, Torrego, Alfons, additional, Lopez-Campos, Jose Luis, additional, Soriano, Joan B., additional, Martinez Moragon, Eva, additional, Izquierdo, Jose Luis, additional, Bobolea, Irina, additional, Callejas, Javier, additional, Plaza, Vicente, additional, Miravitlles, Marc, additional, and Soler-Catalunya, Juan Jose, additional

Published
2017
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224. Concentraciones de yodo y su ingesta en una población de mujeres embarazadas sanas

Author

M. Pilar Bonet-Manso, Cristina Plaza-Vicente, M. Belén Atiénzar-Martínez, and M. Isabel Fuentes-Gómez

Subjects
Physics, Food consumption, General Medicine, Humanities, General Nursing
Abstract

Resumen Objetivo Conocer las concentraciones de yodo en los 2 primeros trimestres de gestacion de las embarazadas atendidas en el Centro de Atencion Primaria (CAP) de Orihuela (Alicante), y su relacion con el consumo de alimentos y suplementos vitaminicos. Metodo Estudio descriptivo prospectivo. Se estudiaron las embarazadas que acudieron en su primera visita a la consulta de las matronas del CAP los meses de noviembre y diciembre de 2005. Las variables estudiadas fueron: determinacion de yodo en orina (se recogieron muestras aisladas de orina), variables epidemiologicas, frecuencia de consumo de alimentos relacionados con el yodo y de suplementos vitaminicos. Estas se recogieron a traves de un cuestionario estructurado, administrado mediante entrevista personal por el equipo de investigacion el primer y segundo trimestres de gestacion. Resultados Se obtuvo una muestra de 104 mujeres. Un 71,6% presento deficiencia de yodo en el primer trimestre, y se observo una disminucion de la deficiencia de un 30,6% en el segundo trimestre. Se encontraron diferencias estadisticamente significativas respecto al consumo de moluscos y suplementos vitaminicos en relacion con la excrecion de yodo en orina. Conclusiones El valor medio de la excrecion urinaria de yodo de las gestantes estudiadas muestra una deficiencia leve en la ingesta de yodo durante el primer trimestre, lo que puede suponer un riesgo para el desarrollo fetal.

Published
2007

225. What pulmonologists think about the asthma–COPD overlap syndrome

Author

Miravitlles, Marc, Alcázar-Navarrete, Bernardino, Alvarez Gutiérrez, Francisco Javier, Bazús, Teresa, Calle Rubio, Myriam, Casanova, Ciro, Cisneros, Carolina, De Torres, Juan Pablo, Entrenas, Luis M., Esteban, Cristóbal, García-Sidro, Patricia, Cosio, Borja G.., Huerta, Arturo, Iriberri, Milagros, Izquierdo, José Luis, López Viña, Antolín, López-Campos, José Luis, Martínez-Moragón, Eva, Pérez de Llano, Luis, Perpiñá, Miguel, Ros, José Antonio, Serrano, José, Soler-Cataluña, Juan José, Torrego, Alfons, Urrutia, Isabel, Plaza, Vicente, Universitat Autònoma de Barcelona, [Miravitlles,M] Pneumology Department, Hospital Universitari Vall d´Hebron, Barcelona, Spain. [Miravitlles,M, López-Campos,L] CIBER de Enfermedades Respiratorias (CIBERES) Madrid, Spain. [Alcázar,B] Respiratory Department, Hospital de Alta Resolución de Loja, Granada, Spain. [Alvarez,FJ, López-Campos,L] Medical-Surgical Unit of Respiratory Diseases, Virgen del Rocio University Hospital, Biomedicine Institute of Seville (IbiS), Seville, Spain. [Bazús,T] Department of Pneumology, Hospital Universitario Central de Asturias, Ovido, Spain. [Calle,M] Department of Pneumology, Hospital Clínico San Carlos, Madrid, Spain. [Casanova,C] Department of Pneumology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. [Cisneros,C] Department of Pneumology, Hospital Universitario de La Princesa/Instituto de Investigación Sanitaria (IIS-IP), Madrid, Spain. [De Torres,JP] Pulmonary Department, Clínica Universidad de Navarra, Pamplona, Spain. [Entrenas,LM] Department of Pneumology, Hospital Universitario Reina Sofía, Córdoba, Spain. [Esteban,C, Urrutia,I] Department of Pneumology, Hospital Galdakao-Usansolo, Galdakao, Spain. [García-Sidro,P] Department of Pneumology, Hospital Universitario de La Plana, Vila-Real, Spain. [Cosio,BC] Department of Pneumology, Hospital Universitario Son Espases IdISPa, Palma de Mallorca, Spain. [Huerta,A] Sección Urgencias Medicina - Neumología, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Spain. [Iriberri,M] Department of Pneumology, Hospital Universitario de Cruces, Bilbao, Spain. [Izquierdo,JL] Department of Pneumology, Hospital Universitario de Guadalajara, Guadalajara, Spain. [López-Viña,A] Department of Pneumology, Hospital Universitario Puerta del Hierro Majadahonda, Madrid, Spain. [Martínez-Moragón,E] Department of Pneumology, Hospital Universitario Dr. Peset, Valencia, Spain. [Pérez de Llano,L] Department of Pneumology, Hospital Universitario Lucus Augusti, Lugo, Spain. [Perpiñá,M] Department of Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. [Ros,JA] Department of Pneumology, Hospital Clínico Universitario Virgen de la Arrinxaca, Murcia, Spain. [Serrano,J] Department of Pneumology, Hospital Comarcal de Inca, Inca, Spain. [Soler-Cataluña,JJ] Department of Pneumology, Hospital Arnau de Vilanova-Liria, Valencia, Spain. [Torrejo,A, Plaza,V] Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain., and Marc Miravitlles has received speaker fees from Almirall, Boehringer Ingelheim, Pfizer, AstraZeneca, Chiesi, Esteve, GlaxoSmithKline, Menarini, Grifols, and Novartis, and consulting fees from Almirall, Boehringer Ingelheim, Cipla, Pfizer, GlaxoSmithKline, Gebro Pharma, CLS Behring, MediImmune, Takeda, Teva, Novartis, and Grifols. Bernardino Alcázar reports personal fees from Novartis AG, Boehringer Ingelheim, GSK, Almirall, AstraZeneca, and grants and personal fees from Menarini. Teresa Bazús has received honoraria or funding for attending scientific meetings from GSK, Chiesi, and Teva. Ciro Casanova has received speaker fees from AstraZeneca, GSK, Novartis, and Almirall y Gebro Pharma and consulting fees from Almirall, Novartis, and GSK. Carolina Cisneros has received speaker or consulting fees from AstraZeneca, GSK, Boehringer Ingelheim, Novartis, Takeda, Vifor Pharma, Chiesi, Orion, and Mundipharma. Luis M Entrenas has in the last 3 years received honoraria for speaking at sponsored meetings from Alter, AstraZeneca, Boehringer Ingelheim, Chiesi, Esteve, Ferrer, GSK, Menarini, MSD, Mundipharma, Novartis, Pfizer, and Teva, as a consultant for Chiesi, Mundipharma, and Novartis, and has received funding/grant support for research projects from not-for-profit foundations, as well as Novartis. Patricia García-Sidro has received fees for scientific meetings, scientific advice, and participating in clinical studies or writing for publications from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Esteve, Ferrer, Gebro, GlaxoSmithKline, Menarini, MSD, Mundipharma, Novartis, Pfizer, Rovi, Takeda-Nycomed, and Teva. Borja G Cosio has in the last 3 years received honoraria for speaking at sponsored meetings from Chiesi, GSK, Boehringer Ingelheim, Novartis, and Pfizer, consultant fees from Pfizer, Chiesi, and GSK, travel grants from Boehringer Ingelheim, Novartis, and Chiesi, and received unrestricted funding/grant support for research projects from a variety of government agencies and not-for-profit foundations, as well as Boehringer Ingelheim, Chiesi, and Menarini. Arturo Huerta has received personal fees from GSK, Novartis, Takeda, Menarini, and Boehringer Ingelheim. José Luis Izquierdo reports personal fees for consulting and lectures from Almirall, AstraZeneca, Bayer, Boehringer Ingelheim, Takeda-Nycomed, Pfizer, and Menarini. Antolin López-Viña has in the last 3 years received honoraria for speaking at sponsored meetings from Chiesi, GSK, Boehringer Ingelheim, Novartis, and Pfizer, as a consultant for Pfizer, Boehringer Ingelheim, and Novartis, has received assistance to meet travel costs from Boehringer Ingelheim, Novartis, Teva, and Chiesi, and has received funding/grant support for research projects from a variety of government agencies and not-for-profit foundations, as well as Chiesi and Menarini. Eva Martínez-Moragón has in the last 3 years received honoraria for speaking at sponsored meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Mundipharma, Teva, and Pfizer. Luis Pérez de Llano has in the last 3 years received honoraria for speaking at sponsored meetings from AstraZeneca, Boehringer Ingelheim, Menarini, Chiesi, GlaxoSmithKline, Teva, Almirall, Mundipharma, Esteve, Novartis, and Pfizer, as a consultant for Mundipharma, Pfizer, Ferrer, and Novartis, has received assistance to meet travel costs from GSK and Novartis, and has received funding/grant support for research projects from SEPAR and SERGAS. Juan José Soler-Cataluña has received speaker fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Esteve, Ferrer, GSK, Merck, Menarini, Sharp & Dohme, Novartis, Takeda, and Pfizer, and consulting fees from Boehringer Ingelheim, GSK, AstraZeneca, Ferrer, Novartis, Almirall, Merck, Sharp & Dohme, and Takeda. Vicente Plaza has in the last 3 years received honoraria for speaking at sponsored meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Merck, Mundipharma, and Pfizer, as a consultant for Mundipharma, Orion and Teva, received assistance to meet travel costs from Boehringer Ingelheim and Chiesi, and received funding/grant support for research projects from a variety of government agencies and not-for-profit foundations, as well as Chiesi, Menarini, and Merck. The authors report no other conflicts of interest in this work.

Subjects
Male, Health Knowledge, Attitudes, Practice, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Questionnaires [Medical Subject Headings], humanos, Disciplines and Occupations::Health Occupations::Specialization [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], broncodilatadores, Anti-asthmatic Agent, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Pulmonary Disease, Chronic Obstructive, Adrenal Cortex Hormones, Risk Factors, immune system diseases, Surveys and Questionnaires, Pulmonary medicine, Pulmonary Medicine, Enfermedad pulmonar obstructiva crónica, Anti-Asthmatic Agents, guidelines, mediana edad, Pulmonologists, Original Research, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], COPD, education.field_of_study, Smoking, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Respiratory System Agents::Anti-Asthmatic Agents::Bronchodilator Agents [Medical Subject Headings], Overlap syndrome, General Medicine, Middle Aged, Prognosis, actitud del personal sanitario, consenso, Bronchodilator Agents, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Causality::Risk Factors [Medical Subject Headings], asma, pronóstico, Consenso, Female, Antiasmáticos, antiasmáticos, Specialization, medicine.medical_specialty, Consensus, Attitude of Health Personnel, Population, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Smoking [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Respiratory System Agents::Anti-Asthmatic Agents [Medical Subject Headings], Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Asthma [Medical Subject Headings], International Journal of Chronic Obstructive Pulmonary Disease, Predictive Value of Tests, medicine, Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive [Medical Subject Headings], Humans, factores de riesgo, especialización, survey, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Research Design::Sensitivity and Specificity::Predictive Value of Tests [Medical Subject Headings], Asthma copd overlap, Intensive care medicine, education, Adrenergic beta-2 Receptor Agonists, Asma, Corticoesteroides, Asthma, pruebas de valores predictivos, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Group Processes::Consensus [Medical Subject Headings], business.industry, Disciplines and Occupations::Health Occupations::Medicine::Internal Medicine::Pulmonary Medicine [Medical Subject Headings], Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones [Medical Subject Headings], hábito de fumar, asthma, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Adrenergic Agents::Adrenergic Agonists::Adrenergic beta-Agonists::Adrenergic beta-2 Receptor Agonists [Medical Subject Headings], medicine.disease, agonistas de receptores adrenérgicos beta-2, Broncodilatadores, Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Attitude to Health::Health Knowledge, Attitudes, Practice [Medical Subject Headings], respiratory tract diseases, medicina pulmonar, Check Tags::Female [Medical Subject Headings], Spain, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Attitude::Attitude of Health Personnel [Medical Subject Headings], Physical therapy, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], business, hormonas de la corteza suprarrenal, ACOS
Abstract

Background: Some patients with COPD may share characteristics of asthma; this is the so-called asthma-COPD overlap syndrome (ACOS). There are no universally accepted criteria for ACOS, and most treatments for asthma and COPD have not been adequately tested in this population. Materials and methods: We performed a survey among pulmonology specialists in asthma and COPD aimed at collecting their opinions about ACOS and their attitudes in regard to some case scenarios of ACOS patients. The participants answered a structured questionnaire and attended a face-to-face meeting with the Metaplan methodology to discuss different aspects of ACOS. Results: A total of 26 pulmonologists with a mean age of 49.7 years participated in the survey (13 specialists in asthma and 13 in COPD). Among these, 84.6% recognized the existence of ACOS and stated that a mean of 12.6% of their patients might have this syndrome. In addition, 80.8% agreed that the diagnostic criteria for ACOS are not yet well defined. The most frequently mentioned characteristics of ACOS were a history of asthma (88.5%), significant smoking exposure (73.1%), and postbronchodilator forced expiratory volume in 1 second/forced vital capacity,0.7 (69.2%). The most accepted diagnostic criteria were eosinophilia in sputum (80.8%), a very positive bronchodilator test (69.2%), and a history of asthma before 40 years of age (65.4%). Up to 96.2% agreed that first-line treatment for ACOS was the combination of a long-acting beta(2)-agonist and inhaled steroid, with a long-acting antimuscarinic agent (triple therapy) for severe ACOS. Conclusion: Most Spanish specialists in asthma and COPD agree that ACOS exists, but the diagnostic criteria are not yet well defined. A previous history of asthma, smoking, and not fully reversible airflow limitation are considered the main characteristics of ACOS, with the most accepted first-line treatment being long-acting beta(2)-agonist/inhaled corticosteroids., The authors want to thank Montserrat Falgueras, Maria Fontanals, Laura Molina, Rosa Palomino, and Sonia Pisa (GOC Networking, Barcelona, Spain) for their help in the organization of the study, data entry and analysis of the questionnaires, and the facilitation of the Metaplan session. This study was funded by Chiesi Spain.

Published
2015

226. Personalized respiratory medicine: Exploring the horizon, addressing the issues

Author

Agusti, Alvar, Antó, Josep Maria, Auffray, Charles, Barbé, Ferran, Barreiro, Esther, Dorca, Jordi, Escarrabill, Joan, Faner, Rosa, Furlong, Laura I, Garcia-Aymerich, Judith, Gea, Joaquim, Lindmark, Bertil, Monsó, Eduard, Plaza, Vicente, Puhan, Milo A, Roca, Josep, Ruiz-Manzano, Juan, Sampietro-Colom, Laura, Sanz, Ferran, Serrano, Luis, Sharpe, James, Sibila, Oriol, Silverman, Edwin K, Sterk, Peter J, Sznajder, Jacob I, University of Zurich, and Agusti, Alvar

Subjects
2740 Pulmonary and Respiratory Medicine, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2706 Critical Care and Intensive Care Medicine
Published
2015

228. Clinical and functional characteristics, possible causes, and impact of chronic cough in patients with cerebellar ataxia, neuropathy, and bilateral vestibular areflexia syndrome (CANVAS).

Author

Palones, Esther, Curto, Elena, Plaza, Vicente, Gonzalez-Quereda, Lidia, Segarra-Casas, Alba, Querol, Luis, Bertoletti, Federico, Rodriguez, María José, Gallano, Pía, and Crespo-Lessmann, Astrid

Subjects
*CHRONIC cough, *CEREBELLAR ataxia, *ESOPHAGEAL motility disorders, *ESOPHAGEAL motility, *NEUROPATHY, *GASTROESOPHAGEAL reflux
Abstract

Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is an hereditary autosomal recessive disease. Recent studies propose including chronic cough (CC) as a symptom of CANVAS. For 10 patients with CANVAS as genetically confirmed by biallelic expansion of the AAGG repeat motif (AAGGGexp) in intron 2 of replication factor C subunit 1 (RFC1), our aim was, as a multidisciplinary team, to describe clinical and functional characteristics and possible causes of CC following European Respiratory Society (ERS) recommendations, and to evaluate CC impact on quality of life (QoL) using self-administered questionnaires (Cough Severity Diary, Leicester Cough Questionnaire, Discrete Emotions Questionnaire, and EQ-5D-5L). In all 10 patients, the CC was a dry cough that developed several years prior to the neurological symptoms (mean 14.2 years); 7 patients had symptoms compatible with gastroesophageal reflux (GER), 5 with pathological GER diagnosed by 24-h esophageal pH testing, and 6 patients had impaired esophageal motility diagnosed by high-resolution esophageal manometry, most frequently ineffective peristalsis. Although further studies are required for confirmation, we conclude that CC may be a characteristic prodrome of CANVAS and may be related to GER and esophageal disorders. Furthermore, CC affects patients' QoL, especially in the psychosocial sphere. [ABSTRACT FROM AUTHOR]

Published
2024
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229. El registro de condiciones generales de la contratación

Author

Sanz Plaza, Vicente, Martín García, María del Lirio, and Universidad de Valladolid. Facultad de Ciencias Sociales, Jurídicas y de la Comunicación

Subjects
Consumidores-Protección-Derecho, Contratos
Abstract

Un contrato de adhesión es un contrato cuyas cláusulas las redacta una sola de las partes y la otra se limita a aceptar o rechazar el contrato en su integridad. Las cláusulas que reglamentan el contrato se denominan condiciones generales de la contratación. El registro de condiciones generales de la contratación es un registro público, hace efectivo el ejercicio de acciones contra las condiciones generales no ajustadas a la ley; que no se produzcan cláusulas abusivas. En este registro se pueden inscribir de manera voluntaria las condiciones generales de la contratación. Existe la obligación de la inscripción de las sentencias de las cláusulas declaradas nulas por los tribunales. Cualquier persona puede solicitar información del registrador de condiciones general de la contratación. Este registro se encuentra en la sección secta del registro de bienes inmuebles; está integrado por un registro central (con sede en Madrid) y tantos registros provinciales como provincias existen., Grado en Relaciones Laborales y Recursos Humanos

Published
2014

230. Causes of death in asthma, COPD and non-respiratory hospitalized patients: a multicentric study

Author

Gregorio Soto-Campos, Jose, Plaza, Vicente, Soriano, Joan B., Cabrera-Lopez, Carlos, Almonacid-Sanchez, Carlos, Vazquez-Oliva, Rosa, Serrano, Jose, Ballaz-Quincoces, Aitor, Padilla-Galo, Alicia, Santos, Vanessa, and Grp Emergente Asma GEA Area Asma

Subjects
Male, humanos, Disease, Respiratory failure, Pulmonary Disease, Chronic Obstructive, Cause of Death, Neoplasms, Hospital Mortality, mediana edad, Cause of death, Aged, 80 and over, neoplasias, COPD, anciano, Medical record, Middle Aged, asma, Cardiovascular diseases, Female, Infection, Research Article, Pulmonary and Respiratory Medicine, medicine.medical_specialty, estudios de casos y controles, enfermedades cardiovasculares, Infections, causas de muerte, Internal medicine, medicine, Humans, Mortality, Intensive care medicine, Asthma, Aged, Retrospective Studies, business.industry, estudios retrospectivos, Case-control study, Retrospective cohort study, infección, medicine.disease, respiratory tract diseases, Spain, Case-Control Studies, business, mortalidad hospitalaria
Abstract

Background: There is limited information on the causes of death in asthma patients. To determine the causes of death in hospitalized asthmatic patients and to compare with those observed in COPD patients and non-respiratory individuals, with a particular interest in associations with previous cardiovascular disease. Methods: Retrospective case-control study which analyzed the deaths of all hospitalized patients admitted for any reason during January, April, July and October of 2008 in 13 Spanish centers. Medical records of deceased patients were reviewed, and demographic and clinical data were collected. Results: A total of 2,826 deaths (mean age 75 years, 56% men) were included in the analysis, of which 82 (2.9%) were of patients with asthma and 283 (10%) with COPD. The most common causes of death in asthma patients were cardiovascular diseases (29.3%), malignancies (20.7%) and infections (14.6%); in COPD patients they were malignancies (26.5%), acute respiratory failure (25.8%) and cardiovascular diseases (21.6%). Asthma, compared to COPD patients, died significantly less frequently from acute respiratory failure and lung cancer. A multivariate logistic regression analysis failed to associate asthma with cardiovascular deaths. Conclusions: Cardiovascular disease is the most frequent cause of death among hospitalized asthma patients. The specific causes of death differ between asthma and COPD patients., The study received a Research Grant in 2009 from SEPAR.

Published
2013

234. Positive bronchodilator response is a poor predictor of future risk in well controlled asthma patients

Author

Pérez de Llano, Luis, primary, Carballada, Francisco, additional, García-Rivero, Juan Luis, additional, Urrutia, Isabel, additional, Martínez-Moragón, Eva, additional, Blanco, Marina, additional, Ramos, Jacinto, additional, Vennera, Maria Carmen, additional, Plaza, Vicente, additional, Cebollero, Pilar, additional, and Merino, María, additional

Published
2016
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238. Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization

Author

Sibila, Oriol, primary, Garcia-Bellmunt, Laia, additional, Giner, Jordi, additional, Rodrigo-Troyano, Ana, additional, Suarez-Cuartin, Guillermo, additional, Torrego, Alfons, additional, Castillo, Diego, additional, Solanes, Ingrid, additional, Mateus, Eder F., additional, Vidal, Silvia, additional, Sanchez-Reus, Ferran, additional, Sala, Ernest, additional, Cosio, Borja G., additional, Restrepo, Marcos I., additional, Anzueto, Antonio, additional, Chalmers, James D., additional, and Plaza, Vicente, additional

Published
2016
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243. Differences in Adherence and Non-Adherence Behaviour Patterns to Inhaler Devices Between COPD and Asthma Patients

Author

Plaza, Vicente, primary, López-Viña, Antolín, additional, Entrenas, Luis Manuel, additional, Fernández-Rodríguez, Concepción, additional, Melero, Carlos, additional, Pérez-Llano, Luis, additional, Gutiérrez-Pereyra, Fernando, additional, Tarragona, Eduard, additional, Palomino, Rosa, additional, and Cosio, Borja G., additional

Published
2016
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245. What pulmonologists think about the asthma–COPD overlap syndrome

Author

Miravitlles,Marc, Alcázar,Bernardino, Alvarez,Francisco Javier, Bazús,Teresa, Calle,Myriam, Casanova,Ciro, Cisneros,Carolina, de-Torres,Juan Pablo, Entrenas,Luis, Esteban,Cristóbal, García-Sidro,Patricia, G Cosio,Borja, Huerta,Arturo, Iriberri,Milagros, Izquierdo,José Luis, López-Viña,Antolín, López-Campos,José Luis, Martínez-Moragón,Eva, Pérez de Llano,Luis, Perpiñá,Miguel, Ros,José, Serrano,José, Soler-Cataluña,Juan José, Torrego,Alfons, Urrutia,Isabel, Plaza,Vicente, Miravitlles,Marc, Alcázar,Bernardino, Alvarez,Francisco Javier, Bazús,Teresa, Calle,Myriam, Casanova,Ciro, Cisneros,Carolina, de-Torres,Juan Pablo, Entrenas,Luis, Esteban,Cristóbal, García-Sidro,Patricia, G Cosio,Borja, Huerta,Arturo, Iriberri,Milagros, Izquierdo,José Luis, López-Viña,Antolín, López-Campos,José Luis, Martínez-Moragón,Eva, Pérez de Llano,Luis, Perpiñá,Miguel, Ros,José, Serrano,José, Soler-Cataluña,Juan José, Torrego,Alfons, Urrutia,Isabel, and Plaza,Vicente

Abstract

Marc Miravitlles,1,2 Bernardino Alcázar,3 Francisco Javier Alvarez,4 Teresa Bazús,5 Myriam Calle,6 Ciro Casanova,7 Carolina Cisneros,8 Juan P de-Torres,9 Luis M Entrenas,10 Cristóbal Esteban,11 Patricia García-Sidro,12 Borja G Cosio,13 Arturo Huerta,14 Milagros Iriberri,15 José Luis Izquierdo,16 Antolín López-Viña,17 José Luis López-Campos,2,4 Eva Martínez-Moragón,18 Luis Pérez de Llano,19 Miguel Perpiñá,20 José Antonio Ros,21 José Serrano,22 Juan José Soler-Cataluña,23 Alfons Torrego,24 Isabel Urrutia,11 Vicente Plaza24 1Pneumology Department, Hospital Universitari Vall d’Hebron, Barcelona, 2CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 3Respiratory Department, Hospital de Alta Resolucion de Loja, Granada, 4Medical-Surgical Unit of Respiratory Diseases, Virgen del Rocio University Hospital, Biomedicine Institute of Seville (IBiS), Seville, 5Department of Pneumology, Hospital Universitario Central de Asturias, Oviedo, 6Department of Pneumology, Hospital Clínico San Carlos, Madrid, 7Department of Pneumology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, 8Department of Pneumology, Hospital Universitario de La Princesa/Instituto de Investigación Sanitaria (IIS-IP), Madrid, 9Pulmonary Department, Clínica Universidad de Navarra, Pamplona, 10Department of Pneumology, Hospital Universitario Reina Sofia, Córdoba, 11Department of Pneumology, Hospital Galdakao-Usansolo, Galdakao, 12Department of Pneumology, Hospital Universitario de La Plana, Vila-real, 13Department of Pneumology, Hospital Universitario Son Espases IdISPa, Palma de Mallorca, 14Sección Urgencias Medicina – Neumología, Institut d’Investigacions Biom&e

Published
2015

248. Exhaled Nitric Oxide Fraction as an Add-On to ACQ-7 for Not Well Controlled Asthma Detection

Author

Plaza, Vicente, Ramos-Barbón, David, Muñoz, Ana María, Fortuna Gutiérrez, Ana Mª, Crespo Lessmann, Astrid, Murio, Cristina, Palomino, Rosa, and Universitat Autònoma de Barcelona

Subjects
Adult, Male, Spirometry, medicine.medical_specialty, Time Factors, lcsh:Medicine, Nitric Oxide, Sensitivity and Specificity, Pulmonary function testing, Maintenance therapy, Surveys and Questionnaires, Asthma control, Internal medicine, Outcome Assessment, Health Care, Humans, Medicine, Anti-Asthmatic Agents, Prospective Studies, lcsh:Science, Asthma, Multidisciplinary, medicine.diagnostic_test, business.industry, lcsh:R, Airway inflammation, Reproducibility of Results, Middle Aged, respiratory system, medicine.disease, Respiratory Function Tests, respiratory tract diseases, Breath Tests, Exhalation, Exhaled nitric oxide, Physical therapy, Sputum, lcsh:Q, Female, medicine.symptom, business, Research Article, Follow-Up Studies
Abstract

Background: The measurement of fractional nitric oxide concentration in exhaled breath (FeNO), a noninvasive indicator of airway inflammation, remains controversial as a tool to assess asthma control. Guidelines currently limit asthma control assessment to symptom and spirometry based appraisals such as the Asthma Control Questionnaire-7 (ACQ-7). We aimed at determining whether adding FeNO to ACQ-7 improves current asthma clinical control assessment, through enhanced detection of not well controlled asthma. Methods: Asthmatic subjects, classified as not well controlled as per ACQ-7 on regular clinical practice, were included in a prospective, multicenter fashion, and had their maintenance treatment adjusted on visit 1. On follow-up (visit 2) four weeks later, the subjects were reevaluated as controlled or not well controlled using ACQ-7 versus a combination of FeNO and ACQ-7. Results: Out of 381 subjects enrolled, 225 (59.1%) had not well controlled asthma on visit 2 as determined by ACQ-7, and 264 (69.3%) as per combined FeNO and ACQ-7. The combination of FeNO to ACQ-7 increased by 14.8% the detection of not well controlled asthma following maintenance therapy adjustment. Conclusions: The addition of FeNO to ACQ-7 increased the detectability of not well controlled asthma upon adjustment of maintenance therapy. Adding a measure of airway inflammation to usual symptom and spirometry based scores increases the efficacy of current asthma clinical control assessment.

Published
2013

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