201. Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified
- Author
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Chandra Kant Pandey, Uttam Singh, Mehdi Raza, Ravinder Pandey, Sanjay Dhiraj, Prabhat K Singh, Anil Agarwal, and Devendra Gupta
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lidocaine ,Adolescent ,medicine.medical_treatment ,Pain medicine ,chemistry.chemical_element ,Pain ,Sodium Chloride ,law.invention ,Magnesium Sulfate ,Randomized controlled trial ,law ,medicine ,Humans ,Elective surgery ,Anesthetics, Local ,Vein ,Saline ,Propofol ,Pain Measurement ,Analgesics ,Magnesium ,business.industry ,General Medicine ,Middle Aged ,Surgery ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Treatment Outcome ,chemistry ,Elective Surgical Procedures ,Anesthesia ,Injections, Intravenous ,Female ,business ,Anesthetics, Intravenous ,Preanesthetic Medication ,medicine.drug - Abstract
Propofol produces anesthesia with rapid recovery. However, it causes pain or discomfort on injection. A number of techniques have been tried for minimizing propofol-induced pain with variable results. We have compared the efficacy of magnesium and lidocaine for the prevention of propofol induced pain.Three hundred ASA I and II adults undergoing elective surgery were randomly assigned into three groups of 100 each. Group I received magnesium sulfate 1 g, Group II received lidocaine 2% (40 mg) and Group III received normal saline, all in a volume of 2 mL and accompanied by venous occlusion for one minute. Induction with propofol 2.5 mg.kg(-1) was accomplished following the release of venous occlusion. Pain was assessed on a four-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain at the time of pretreatment and propofol injection. Results were analyzed by 'Z' test. A P value of0.05 was considered as significant.Pain during i.v. pretreatment with magnesium was 31% as compared to 2% for both the lidocaine and control groups (P0.05). Seventy-six percent of patients in the control group had pain during i.v. propofol as compared to 32% and 42% in the magnesium and the lidocaine groups respectively (P0.05). Lidocaine and magnesium pretreatment were equally effective in attenuating pain during the propofol injection (P0.05).Intravenous magnesium and lidocaine pretreatment are equally effective in attenuating propofol-induced pain. However, magnesium pretreatment itself causes pain. Therefore, there is no justification in the use of magnesium pretreatment for attenuating pain associated with i.v. propofol.
- Published
- 2004