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738 results on '"Querfeld, Christiane"'

201. Long-term follow-up and management of small and medium-sized CD4+T cell lymphoma and CD8+lymphoid proliferations of acral sites: a multicenter experience

Author

Virmani, Pooja, primary, Jawed, Sarah, additional, Myskowski, Patricia L., additional, Horwitz, Steven, additional, Skripnik Lucas, Anna, additional, Moskowitz, Alison, additional, Pulitzer, Melissa, additional, Zain, Jasmine, additional, Rosen, Steven T., additional, and Querfeld, Christiane, additional

Published
2016
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202. Pembrolizumab-associated sarcoidosis

Author

Cotliar, Jonathan, primary, Querfeld, Christiane, additional, Boswell, William J., additional, Raja, Naveen, additional, Raz, Dan, additional, and Chen, Robert, additional

Published
2016
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203. Autoimmune Bullous Skin Disorders with Immune Checkpoint Inhibitors Targeting PD-1 and PD-L1

Author

Naidoo, Jarushka, primary, Schindler, Katja, additional, Querfeld, Christiane, additional, Busam, Klaus, additional, Cunningham, Jane, additional, Page, David B., additional, Postow, Michael A., additional, Weinstein, Alyona, additional, Lucas, Anna Skripnik, additional, Ciccolini, Kathryn T., additional, Quigley, Elizabeth A., additional, Lesokhin, Alexander M., additional, Paik, Paul K., additional, Chaft, Jamie E., additional, Segal, Neil H., additional, D'Angelo, Sandra P., additional, Dickson, Mark A., additional, Wolchok, Jedd D., additional, and Lacouture, Mario E., additional

Published
2016
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204. Targeting CD47 in Sézary syndrome with SIRPαFc

Author

Johnson, Lisa D. S., Banerjee, Swati, Kruglov, Oleg, Viller, Natasja Nielsen, Horwitz, Steven M., Lesokhin, Alexander, Zain, Jasmine, Querfeld, Christiane, Chen, Robert, Okada, Craig, Sawas, Ahmed, O’Connor, Owen A., Sievers, Eric L., Shou, Yaping, Uger, Robert A., Wong, Mark, and Akilov, Oleg E.

Abstract

Sézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma, has limited treatment options and rare occurrences of long-term remission, thus warranting research into new treatment approaches. CD47 has emerged as a promising target for multiple tumor types, but its role in SS remains unknown. Here, we show that CD47 is highly expressed on Sézary cells in the peripheral blood and skin, and the high level of CD47 expression correlates with worse overall survival (OS) in patients with SS. We also demonstrate that CD47 expression on Sézary cells is under the influence of interleukin 4 (IL-4), IL-7, and IL-13. Signal regulatory protein αFc (SIRPαFc; TTI-621), a novel CD47 decoy receptor, triggers macrophage-mediated phagocytosis of Sézary cells and, when administered in clinical trial settings, results in significant tumor load reduction. We conclude that inhibition of the CD47-SIRPα signaling pathway has therapeutic benefit for patients with SS. This trial was registered at www.clinicaltrials.gov as #NCT02663518.

Published
2019
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207. Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

Author

Querfeld, Christiane

Subjects
Cancer Management and Research, hemic and lymphatic diseases
Abstract

Janet Y Li1, Steven Horwitz2, Alison Moskowitz2, Patricia L Myskowski3, Melissa Pulitzer4, Christiane Querfeld31College of Physicians and Surgeons, Columbia University, 2Department of Medicine, Lymphoma Service, 3Department of Medicine, Dermatology Service, 4Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USAAbstract: Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin), and pralatrexate in CTCL.Keywords: novel targets, histone deacetylase inhibitors, pralatrexate, bortezomib, cutaneous T cell lymphoma

Published
2012

209. Jejunal adenocarcinoma with cutaneous metastasis

Author

Chung, Esther, Chung, Esther, Syklawer, Ericka, Pulitzer, Melissa P, Marchetti, Michael A, Querfeld, Christiane, Myskowski, Patricia L, Chung, Esther, Chung, Esther, Syklawer, Ericka, Pulitzer, Melissa P, Marchetti, Michael A, Querfeld, Christiane, and Myskowski, Patricia L

Abstract

Small bowel adenocarcinoma (SBA) is a rare primary gastrointestinal malignancy. We present a 60-year old man who developed a cutaneous metastasis of jejunal adenocarcinoma to his neck. This case highlights the clinicopathologic and immunophenotypic features of this uncommon cutaneous metastasis.

Published
2015

210. High-Depth, Targeted, Next Generation Sequencing Identifies Novel Genetic Alterations in Cutaneous T-Cell Lymphoma

Author

Argyropoulos, Kimon V., primary, Horwitz, Steven M, additional, Rapaport, Franck, additional, Velardi, Enrico, additional, Myskowski, Patricia, additional, Querfeld, Christiane, additional, Pulitzer, Melissa, additional, Dogan, Ahmet, additional, Gallagher, Meighan, additional, Socci, Nicholas D., additional, Levine, Ross L., additional, Patel, Minal, additional, Galasso, Natasha, additional, van den Brink, Marcel, additional, and Palomba, Lia, additional

Published
2015
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212. Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model

Author

Scarisbrick, Julia J., primary, Prince, H. Miles, additional, Vermeer, Maarten H., additional, Quaglino, Pietro, additional, Horwitz, Steven, additional, Porcu, Pierluigi, additional, Stadler, Rudolf, additional, Wood, Gary S., additional, Beylot-Barry, Marie, additional, Pham-Ledard, Anne, additional, Foss, Francine, additional, Girardi, Michael, additional, Bagot, Martine, additional, Michel, Laurence, additional, Battistella, Maxime, additional, Guitart, Joan, additional, Kuzel, Timothy M., additional, Martinez-Escala, Maria Estela, additional, Estrach, Teresa, additional, Papadavid, Evangelia, additional, Antoniou, Christina, additional, Rigopoulos, Dimitis, additional, Nikolaou, Vassilki, additional, Sugaya, Makoto, additional, Miyagaki, Tomomitsu, additional, Gniadecki, Robert, additional, Sanches, José Antonio, additional, Cury-Martins, Jade, additional, Miyashiro, Denis, additional, Servitje, Octavio, additional, Muniesa, Cristina, additional, Berti, Emilio, additional, Onida, Francesco, additional, Corti, Laura, additional, Hodak, Emilia, additional, Amitay-Laish, Iris, additional, Ortiz-Romero, Pablo L., additional, Rodríguez-Peralto, Jose L., additional, Knobler, Robert, additional, Porkert, Stefanie, additional, Bauer, Wolfgang, additional, Pimpinelli, Nicola, additional, Grandi, Vieri, additional, Cowan, Richard, additional, Rook, Alain, additional, Kim, Ellen, additional, Pileri, Alessandro, additional, Patrizi, Annalisa, additional, Pujol, Ramon M., additional, Wong, Henry, additional, Tyler, Kelly, additional, Stranzenbach, Rene, additional, Querfeld, Christiane, additional, Fava, Paolo, additional, Maule, Milena, additional, Willemze, Rein, additional, Evison, Felicity, additional, Morris, Stephen, additional, Twigger, Robert, additional, Talpur, Rakhshandra, additional, Kim, Jinah, additional, Ognibene, Grant, additional, Li, Shufeng, additional, Tavallaee, Mahkam, additional, Hoppe, Richard T., additional, Duvic, Madeleine, additional, Whittaker, Sean J., additional, and Kim, Youn H., additional

Published
2015
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214. Histopathologic Features of Cutaneous Acute Graft-Versus-Host Disease in T-Cell–Depleted Peripheral Blood Stem Cell Transplant Recipients

Author

Fischer, Alyssa, primary, Jakubowski, Ann A., additional, Lacouture, Mario E., additional, Hollmann, Travis J., additional, Drucker, Aaron M., additional, Maloy, Molly, additional, Prockop, Susan, additional, Querfeld, Christiane, additional, Busam, Klaus J., additional, and Pulitzer, Melissa P., additional

Published
2015
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215. A phase I/II trial of the combination of romidepsin and lenalidomide in patients with relapsed/refractory lymphoma and myeloma: Activity in T-cell lymphoma.

Author

Mehta-Shah, Neha, primary, Lunning, Matthew Alexander, additional, Boruchov, Adam M., additional, Ruan, Jia, additional, Nair, Sumithra, additional, Lynch, Peggy, additional, Byrne, Regina, additional, Moskowitz, Alison J., additional, Matasar, Matthew J., additional, Gerecitano, John F., additional, Hamlin, Paul A., additional, Leonard, John, additional, Moskowitz, Craig H., additional, Myskowski, Patricia L., additional, Querfeld, Christiane, additional, Nolan, Patrick, additional, Palomba, Maria Lia, additional, Straus, David J., additional, Zelenetz, Andrew David, additional, and Horwitz, Steven M., additional

Published
2015
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218. A Single Direct Intratumoral Injection of TTI-621 (SIRPαFc) Induces Antitumor Activity in Patients with Relapsed/Refractory Mycosis Fungoides and Sézary Syndrome: Preliminary Findings Employing an Immune Checkpoint Inhibitor Blocking the CD47 “Do Not Eat” Signal

Author

Querfeld, Christiane, Thompson, John, Taylor, Matthew, Pillai, Raju, Johnson, Lisa DS, Catalano, Tina, Petrova, Penka S., Uger, Robert A., Irwin, Meghan, Sievers, Eric L, and Akilov, Oleg E.

Published
2017
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221. Clinical Outcome and Prognosis of Young Patients with Mycosis Fungoides.

Author

Virmani, Pooja, Levin, Laura, Myskowski, Patricia L., Flores, Eileen, Marchetti, Michael A., Lucas, Anna Skripnik, Pulitzer, Melissa, Horwitz, Steven, Trippett, Tanya, Moskowitz, Alison, and Querfeld, Christiane

Subjects
MYCOSIS fungoides, HEALTH outcome assessment, HYPOPIGMENTATION, SURVIVAL analysis (Biometry), DISEASE progression, HEALTH of African Americans, PROGNOSIS
Abstract

Background/Objectives Mycosis fungoides (MF) in young patients is rare and may have atypical presentations. There are limited data in these patients. The objective was to determine the clinical outcome and prognosis of young patients with MF. Methods A search of our institutional cancer registry database was conducted for patients diagnosed with MF at younger than 30 years of age. Results Our study included 74 patients (median age at diagnosis 25.5 yrs). Sixty-five (88%) presented with early stage disease and variants of MF ( n = 44 [59%]), leading to a median delay in diagnosis of 2.5 years. Hypopigmented MF ( n = 27 [36.5%]) was the most common variant, affecting predominantly African American (44.4% vs 19%; p = 0.02) and younger (20 vs 26 yrs; p < 0.001) patients. All patients with hypopigmented MF presented with early stage disease and were less likely to develop progressive disease (PD) than those with other variants (11% vs 34%; p = 0.03). Nineteen patients (26%) developed PD during a median follow-up of 3.5 years, which was associated with advanced-stage disease (89% vs 17%; p < 0.001), older age (>20 yrs) (31% vs 13%; p = 0.08), African American race (52.6% vs 20%; p = 0.009), and poikilodermatous presentation (p < 0.01). Overall survival was good (97.2% at 5 yrs, 95.9% at 10 yrs) despite the delay in diagnosis and atypical presentation. Conclusions Progressive disease is associated with older age, African American race, the poikilodermatous variant, and advanced-stage disease. The hypopigmented variant is a common presentation in young patients and has an indolent disease course. Our study confirms an overall favorable prognosis in young patients with MF. [ABSTRACT FROM AUTHOR]

Published
2017
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228. Multicenter Case Series of Indolent Small/Medium-Sized CD8+ Lymphoid Proliferations With Predilection for the Ear and Face

Author

Li, Janet Y., primary, Guitart, Joan, additional, Pulitzer, Melissa P., additional, Subtil, Antonio, additional, Sundram, Uma, additional, Kim, Youn, additional, Deonizio, Janyana, additional, Myskowski, Patricia L., additional, Moskowitz, Alison, additional, Horwitz, Steven, additional, and Querfeld, Christiane, additional

Published
2014
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229. Multi-Kinase Inhibitor with Anti-p38γ Activity in Cutaneous T-Cell Lymphoma

Author

Zhang, Xu Hannah, Nam, Sangkil, Wu, Jun, Chen, Chih-Hong, Liu, Xuxiang, Li, Hongzhi, McKeithan, Timothy, Gong, Qiang, Chan, Wing C., Yin, Hongwei Holly, Yuan, Yate-Ching, Pillai, Raju, Querfeld, Christiane, Horne, David, Chen, Yuan, and Rosen, Steven T.

Abstract

Current cutaneous T-cell lymphoma (CTCL) therapies are marked by an abbreviated response, subsequent drug resistance, and poor prognosis for patients with advanced disease. An understanding of molecular regulators involved in CTCL is needed to develop effective targeted therapies. One candidate regulator is p38γ, a mitogen-activated protein kinase crucial for malignant T-cell activity and growth. p38γ gene expression is selectively increased in CTCL patient samples and cell lines but not in healthy T cells. In addition, gene silencing of p38γ reduced CTCL cell viability, showing a key role in CTCL pathogenesis. Screening p38γ inhibitors is critical for understanding the mechanism of CTCL tumorigenesis and developing therapeutic applications. We prioritized a potent p38γ inhibitor (F7, also known as PIK75) through a high-throughput kinase inhibitor screen. At nanomolar concentrations, PIK75, a multiple kinase inhibitor, selectively killed CD4+malignant CTCL cells but spared healthy CD4+cells; induced significant reduction of tumor size in mouse xenografts; and effectively inhibited p38γ enzymatic activity and phosphorylation of its substrate, DLGH1, in CTCL cells and mouse xenografts. Here, we report that PIK75 has a potential clinical application to serve as a scaffold molecule for the development of a more selective p38γ inhibitor.

Published
2018
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230. Correction to: Real-Life Barriers to Diagnosis of Early Mycosis Fungoides: An International Expert Panel Discussion.

Author

Hodak, Emmilia, Geskin, Larisa, Guenova, Emmanuella, Ortiz-Romero, Pablo L., Willemze, Rein, Zheng, Jie, Cowan, Richard, Foss, Francine, Mangas, Cristina, and Querfeld, Christiane

Subjects
MYCOSIS fungoides, EARLY diagnosis
Abstract

The article presents the discussion on correction "Real‑Life Barriers to Diagnosis of Early Mycosis Fungoides: An International Expert Panel Discussion."

Published
2023
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234. Clinical manifestations and pathogenesis of cutaneous lymphomas: current status and future directions.

Author

Rubio‐Gonzalez, Belen, Zain, Jasmine, Rosen, Steven T., and Querfeld, Christiane

Subjects
LYMPHOMAS, KILLER cells, SYMPTOMS, ETIOLOGY of diseases, THERAPEUTICS
Abstract

The primary cutaneous lymphomas are a heterogeneous group of T-, Natural Killer- and B- cell neoplasms with a wide range of clinical and pathological presentations, and with very different prognoses compared to systemic lymphomas. Recent studies have shown that the skin microenvironment, which is composed of various immune cell subsets as well as their spatial distribution and T-cell interactions through different chemokines and cytokines, has an important role in the development and pathogenesis of cutaneous lymphomas and has assisted in the development of novel and more effective immunotherapies. The following review will focus on the major subtypes of primary cutaneous lymphomas, including the clinical and histological patterns, molecular hallmarks, and current and future treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2017
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235. Long-term follow-up and management of small and medium-sized CD4+ T cell lymphoma and CD8+ lymphoid proliferations of acral sites: a multicenter experience.

Author

Virmani, Pooja, Jawed, Sarah, Myskowski, Patricia L., Horwitz, Steven, Skripnik Lucas, Anna, Moskowitz, Alison, Pulitzer, Melissa, Zain, Jasmine, Rosen, Steven T., and Querfeld, Christiane

Subjects
CUTANEOUS T-cell lymphoma, CD4 antigen, IMMUNOHISTOCHEMISTRY, B cells, SKIN disease treatment
Abstract

Background Primary cutaneous CD4+ small-medium pleomorphic T cell lymphoma ( SMPTCL) is a low-grade cutaneous T cell lymphoma. Its clinical and histopathologic features are comparable with those of CD8+ lymphoid proliferations ( LPs) of the ear and acral sites. Objectives We performed a retrospective analysis of patients with CD4+ SMPTCL or CD8+ LP to elucidate the clinical course, prognosis, and outcomes. Methods Demographic, clinical, and treatment data were reviewed. Histopathologic data based on architectural, cytomorphologic, and immunohistochemical features were assessed. Immunohistochemical staining for T and B cell markers was evaluated. Results A total of 25 patients including 22 with CD4+ SMPTCL and three with CD8+ LP were identified. All patients presented with a single lesion, predominantly on the head, neck, or upper trunk (84%). No patients showed extracutaneous disease at any evaluation. The most common histopathologic changes showed a dense nodular infiltrate of small cells with hyperchromatic nuclei without significant follicular or adnexal involvement. Patients were treated with excision (48%), local radiation (28%), or topical or intralesional steroids (24%). All patients achieved complete resolution of disease. Five patients demonstrated cutaneous relapse at new sites. Conclusions The CD4+ SMPTCL/ CD8+ LP subgroup usually presents with solitary lesions and demonstrates an indolent clinical course. Typical presentation, classic histopathology, widespread expression of follicular T helper cell markers, and loss of a T cell antigen are diagnostic features of CD4+ SMPTCL, whereas monomorphous CD8+ infiltrate without follicular T helper cell markers is consistent with CD8+ LP. Local skin-directed therapy is appropriate in these patients. [ABSTRACT FROM AUTHOR]

Published
2016
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237. Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies.

Author

Mancebo, Silvia E., Cordova, Miguel, Myskowski, Patricia L., Flores, Eileen S., Busam, Klaus, Jawed, Sarah I., Skripnik, Anna, Rajadhyaksha, Milind, and Querfeld, Christiane

Subjects
MYCOSIS fungoides, SKIN biopsy, REFLECTANCE spectroscopy, GENE rearrangement, T cell receptors
Abstract

Background Mycosis fungoides/Sézary syndrome ( MF/ SS) often requires multiple skin biopsies for definitive diagnosis. In vivo reflectance confocal microscopy ( RCM) visualizes high-resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF/ SS using RCM and to correlate RCM features with histopathology and T-cell receptor ( TCR) gene rearrangement studies. Methods A cohort of patients with active/recurrent or suspicious MF/ SS disease was prospectively recruited for RCM imaging and histopathologic/ RCM images were evaluated. Statistical analyses were performed to identify unique RCM features and to correlate RCM features with histopathologic findings and TCR rearrangement studies. Results Eighty-three lesions were evaluated. Correlation between RCM and histopathology was moderate for all relatable features (κ = 0.41, p<0.001), almost perfect for intraepidermal atypical lymphocytes [prevalence and bias-adjusted kappa ( PABAK) = 0.90], and fair for Pautrier collections (κ = 0.32, p = 0.03). Lesions with Pautrier collections identified by RCM were significantly more likely to show TCR clonality (p = 0.04) and diagnostic features of MF/ SS on histopathology (p = 0.03). Conclusions Our study captures morphologic RCM criteria for a variety of skin lesions. Pautrier collections visualized by RCM are associated with improved histopathologic diagnosis and detection of TCR gene clonality. Although further studies are needed to validate the diagnostic implications of RCM for MF/ SS, our study highlights the potential utility of RCM. [ABSTRACT FROM AUTHOR]

Published
2016
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241. Primer of Dermatopathology, 3rd ed

Author

Querfeld, Christiane

Subjects
Primer of Dermatopathology, 3rd ed (Book) -- Book reviews, Books -- Book reviews, Health
Published
2003

246. Multicenter Phase II Trial of Temozolomide in Mycosis Fungoides/Sézary Syndrome: Correlation with O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Proteins

Author

Querfeld, Christiane, primary, Rosen, Steven T., additional, Guitart, Joan, additional, Rademaker, Alfred, additional, Pezen, David S., additional, Dolan, M. Eileen, additional, Baron, Joseph, additional, Yarosh, Daniel B., additional, Foss, Francine, additional, and Kuzel, Timothy M., additional

Published
2011
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247. Multicenter phase II trial of enzastaurin in patients with relapsed or refractory advanced cutaneous T-cell lymphoma

Author

Querfeld, Christiane, primary, Kuzel, Timothy M., additional, Kim, Youn H., additional, Porcu, Pierluigi, additional, Duvic, Madeleine, additional, Musiek, Amy, additional, Rook, Alain H., additional, Mark, Lawrence A., additional, Pinter-brown, Lauren, additional, Hamid, Oday, additional, Lin, Boris, additional, Bian, Ying, additional, Boye, Mark, additional, Day, Jeannette M., additional, and Rosen, Steven T., additional

Published
2011
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248. Sézary syndrome: Immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC)

Author

Olsen, Elise A., primary, Rook, Alain H., additional, Zic, John, additional, Kim, Youn, additional, Porcu, Pierluigi, additional, Querfeld, Christiane, additional, Wood, Gary, additional, Demierre, Marie-France, additional, Pittelkow, Mark, additional, Wilson, Lynn D., additional, Pinter-Brown, Lauren, additional, Advani, Ranjana, additional, Parker, Sareeta, additional, Kim, Ellen J., additional, Junkins-Hopkins, Jacqueline M., additional, Foss, Francine, additional, Cacchio, Patrick, additional, and Duvic, Madeleine, additional

Published
2011
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