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540 results on '"Rezai, Mohammad"'

202. The Cardiovascular Health in Ambulatory Care Research Team (CANHEART)

Author

Tu, Jack V., primary, Chu, Anna, additional, Donovan, Linda R., additional, Ko, Dennis T., additional, Booth, Gillian L., additional, Tu, Karen, additional, Maclagan, Laura C., additional, Guo, Helen, additional, Austin, Peter C., additional, Hogg, William, additional, Kapral, Moira K., additional, Wijeysundera, Harindra C., additional, Atzema, Clare L., additional, Gershon, Andrea S., additional, Alter, David A., additional, Lee, Douglas S., additional, Jackevicius, Cynthia A., additional, Bhatia, R. Sacha, additional, Udell, Jacob A., additional, Rezai, Mohammad R., additional, and Stukel, Thérèse A., additional

Published
2015
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205. FarsiTag: A part-of-speech tagging system for Persian.

Author

Rezai, Mohammad Javad and Miangah, Tayebeh Mosavi

Subjects
*PERSIAN language, *SEQUENCE (Linguistics), *SYNTAX (Grammar), *MORPHEMICS, *ORTHOGRAPHY & spelling
Abstract

FarsiTag is a tagging system capable of assigning the most probable part-of-speech (POS) tags to Persian words in a text. In this system, some linguistic rules have been used to select the best POS tag for every Persian word. The present study aims to report the processes during which a robust tagging system--FarsiTag--was designed and implemented on Persian texts. A POS-tagged parallel corpus of English-Persian containing about 5,000,000 words has also been developed as a side-product of the mentioned tagger. An experiment has been conducted to evaluate the performance of the system while tagging unrestricted Persian texts. The highest rate of error traces back to medical and religious genres, while the lowest system error type is related to the scientific texts. The total error rate considering all domains is as low as 1.4%, with the overall system accuracy of 98.6% which is very promising for a language like Persian. [ABSTRACT FROM AUTHOR]

Published
2017
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206. Treatment Delay and Total Delay among Pulmonary Tuberculosis Patients in the North of Iran: Application Survival Data Analysis.

Author

Yazdani-Charati, Jamshid, Rezai, Mohammad Sadegh, Fendereski, Afsane, Mohammadi, Soraya, and Alipour, Nadia

Subjects
*TREATMENT delay (Medicine), *TUBERCULOSIS treatment, *DIAGNOSIS of HIV infections
Abstract

Background: Tuberculosis (TB) remains the leading cause of death among infectious diseases worldwide. Identifying the factors associated with the treatment delay and total delay would be helpful in the prevention of tuberculosis and in reducing the burden on the health care system. The objective of this study was to assess the treatment delay and total delay in TB patients and investigate the factors causing these delays. Materials and Methods: This was a longitudinal study conducted in 2009-2015. Our study consisted of 1694 TB patients registered in the TB center of Mazandaran province. Data regarding the patients' demographic characteristics and clinical factors associated with treatment delay and total delay were analyzed. Kaplan Meier plots and log rank tests were used to assess the survival pattern. Cox proportional hazards model for multivariable analysis was discussed. We used mean values and median (Q2) [first quartile (Q1)-third quartile (Q3)] to describe delays. Results: The median treatment delay and total delay were 35 (ranged 23-80) and 36 (ranged 24-82) days, respectively. The mean age of TB patients was 47.40±20.3. No significant association was found between the location of residence, nationality, gender, and type of pulmonary TB patients with treatment delay and total delay. Additionally, age, prison status of patients, HIV test, and contact history had a significant relationship with the treatment delay and total delay (p-value <0.05). It was shown that the median total delay in men patients in the ≤14 year-old age group, imprisoner patients, rural patients, patients who have not received an HIV test, smear negative patients, those who are Iranian, and TB patients whose contact history was unknown was lower than that of others. The highest median treatment delay and total delay was in the >60 age groups, and were 41 and 44 days, respectively. Treatment delay was the same as the total delay except in the place of residence variable; median treatment delay among urban patients was less than that of rural patients. Conclusion: According to this study age, prison status of patients, HIV test and contact history had a significant relationship with the treatment delay and total delay (P-value<0.05). Understanding the factors that are closely associated with these delays is essential to effectively control TB and could be helpful in reducing these delays. [ABSTRACT FROM AUTHOR]

Published
2017

213. Inhalation phage therapy as a new approach to preventing secondary bacterial pneumonia in patients with moderate to severe COVID-19: A double-blind clinical trial study

Author

Samaee, Hamid Reza, Eslami, Gohar, Rahimzadeh, Golnar, Saeedi, Majid, Davoudi Badabi, Alireza, Asare-Addo, Kofi, Nokhodchi, Ali, Roozbeh, Fatemeh, Moosazadeh, Mahmood, Ghasemian, Roya, Alikhani, Ahmad, and Rezai, Mohammad Sadegh

Abstract

Inhalation phage therapy is proposed as a replacement approach for antibiotics in the treatment of pulmonary bacterial infections. This study investigates phage therapy on bacterial pneumonia in patients with moderate to severe COVID-19 via the inhalation route. In this double-blind clinical trial, 60 patients with positive COVID-19 hospitalized in three central Mazandaran hospitals were chosen and randomly divided into two intervention and control groups. Standard country protocol drugs plus 10 mL of phage suspension every 12 h with a mesh nebulizer was prescribed for 7 days in the intervention group. The two groups were compared in terms of O2Sat, survival rate, severe secondary pulmonary bacterial infection and duration of hospitalization. Comparing the results between the intervention and control group, in terms of the trend of O2Sat change, negative sputum culture, no fever, no dyspnea, duration of hospitalization, duration of intubation and under ventilation, showed that the difference between these two groups was statistically different (P value < 0.05). In conclusion, inhalation phage therapy may have a potential effect on secondary infection and in the outcome of COVID-19 patients. However, more clinical trials with control confounding factors are needed to further support this concept.

Published
2023
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214. Synthesizing ROOM Models from Message Sequence Chart Specifications

Author

Leue, Stefan, Mehrmann, Lars, and Rezai, Mohammad

Subjects
ddc:004
Abstract

Message Sequence Chart (MSC) specifications have found their way into many software engineering methodologies and CASE tools, in particular in the area of telecommunications and concurrent real-time systems. MSC specifications often represent early life-cycle requirements and high-level design specifications. We are considering terating and branching MSC specifications according to ITU-T Recommendation Z.120. We show how these specifications can be analyzed with respect to their software architectural content, induding structure and bchavior. We present algorithms for the automated synthesis of Real-Time Object-Oriented Modeling (ROOM) models from MSC specifications and discuss their implementation in the MESA toolset. The automation of the synthesis contributes to making the transition from high-level, message exchange-oriented views to the level of a full life-cycle architecture description more efficient and reliable. This means that we are contributing to making Z.120 MSC specifications more useful in the software engineering process.

Published
1998

216. Association between publication of appropriate use criteria and the temporal trends in diagnostic angiography in stable coronary artery disease: A population-based study.

Author

Arbel, Yaron, Qiu, Feng, Bennell, Maria C., Austin, Peter C., Roifman, Idan, Rezai, Mohammad R., Tu, Jack V., Ko, Dennis T., and Wijeysundera, Harindra C.

Abstract

Background: The appropriate use criteria (AUC) were developed to aid clinicians in making clinical decisions regarding coronary angiography. The aim of the present study was to evaluate the association between the publication of the AUC criteria in diagnostic angiography and rates of angiography in Ontario.Methods: Our cohort consisted of all patients who underwent coronary angiography in Ontario from 1st October 2008 to 31st October 2013 for the indication of suspected stable coronary artery disease. We determined monthly age- and sex-standardized rates of angiography per 100,000 adults. To determine the association between the publication of the AUC for diagnostic angiograms and the rates of angiography, we conducted a time series analysis using an autoregressive integrated moving average model. As a sensitivity analyses, we evaluated the impact of the AUC on the rates of percutaneous coronary intervention (PCI) per 100 angiograms.Results: We included 114,551 angiograms for stable coronary artery disease. In the period prior to the publication of the AUC, the average monthly age- and sex-standardized rate of angiography was 18.7 per 100,000; post-AUC, the average monthly rate decreased to 17.6 per 100,000 adults (P = .037). In contrast, in the 29,358 PCIs included in the analysis, the monthly PCI rates per 100 angiograms were unchanged (25.2 pre-AUC; 26.8 post-AUC; P = .29). In the sensitivity analysis, the rate of appropriate/inappropriate and uncertain indication did not significantly change over the study period.Conclusions: The publication of the diagnostic angiography AUC criteria was associated with a decrease in the population rates of diagnostic angiography. This suggests that the AUC potentially was associated with an increased threshold to pursue invasive diagnostic testing. [ABSTRACT FROM AUTHOR]

Published
2016
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217. Utilization of cardiac computed tomography angiography and outpatient invasive coronary angiography in Ontario, Canada.

Author

Roifman, Idan, Rezai, Mohammad R., Wijeysundera, Harindra C., Chow, Benjamin J.W., Wright, Graham A., and Tu, Jack V.

Abstract

Background Cardiac computed tomography angiography (coronary CTA) has emerged as a non-invasive method of diagnosing coronary artery disease. The extent of utilization and uptake of this technology since initiation of its funding by the government of Ontario is unknown. Objectives The aim of our study was to examine coronary CTA utilization and the rates of elective invasive coronary angiography and revascularization before and after funding initiation. Methods We studied all coronary CTAs performed on adults in Ontario after initiation of funding. We also used an interrupted time series analysis to compare the average monthly rates of invasive angiography and revascularization before and after initiation of funding. Results There was an initial steep increase in age-and sex-standardized rates of coronary CTA from 5.0 to 11.4/100,000 over the first two quarters after funding initiation. Afterwards, there was a gradual increase in utilization from 11.4 to 17.1/100,000 over two subsequent calendar years. There was a significant reduction in both the mean monthly outpatient invasive coronary angiography (from 20.7 to 19.9 per 100,000 (p = 0.0004)) and revascularization (from 4.9 to 4.4 per 100,000 (p < 0.0001)) rates in the three years following introduction of the coronary CTA billing code as compared to the three prior to its introduction. Conclusions Since the introduction of coronary CTA funding in Ontario, there has been a steady and controlled increase in its utilization. The increasing use of coronary CTA was associated with a reduction in both the rates of invasive angiography and revascularization. [ABSTRACT FROM AUTHOR]

Published
2015
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219. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Wang, Haidong, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Abraha, Haftom Niguse, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M E, Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adetifa, Ifedayo Morayo O, Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Anurag, Agrawal, Sutapa, Ahmad Kiadaliri, Aliasghar, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibthiel, Aiyar, Sneha, Akanda, Ali Shafqat, Akinyemiju, Tomi F, Akseer, Nadia, Al Lami, Faris Hasan, Alabed, Samer, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alasfoor, Deena, Aldridge, Robert William, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Alhabib, Samia, Ali, Raghib, Alizadeh-Navaei, Reza, Aljunid, Syed M, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allam, Shalini D, Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ameh, Emmanuel A, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Asghar, Rana Jawad, Assadi, Reza, Assaye, Ashagre Molla, Atey, Tesfay Mehari, Atre, Sachin R, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Balalla, Shivanthi, Barac, Aleksandra, Barber, Ryan M, Barboza, Miguel A, Barker-Collo, Suzanne L, Bärnighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bennett, James R, Bensenor, Isabela M, Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Beuran, Mircea, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A, Bicer, Burcu Kucuk, Bidgoli, Hassan Haghparast, Bikbov, Boris, Birungi, Charles, Biryukov, Stan, Bisanzio, Donal, Bizuayehu, Habtamu Mellie, Bjerregaard, Peter, Blosser, Christopher D, Boneya, Dube Jara, Boufous, Soufiane, Bourne, Rupert R A, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Brugha, Traolach S, Bukhman, Gene, Bulto, Lemma Negesa Bulto, Bumgarner, Blair Randal, Burch, Michael, Butt, Zahid A, Cahill, Leah E, Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael Ricardo, Car, Josip, Car, Mate, Cárdenas, Rosario, Carpenter, David O, Carrero, Juan Jesus, Carter, Austin, Castañeda-Orjuela, Carlos A, Castro, Franz F, Castro, Ruben Estanislao, Catalá-López, Ferrán, Chen, Honglei, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G, Cirillo, Massimo, Cohen, Aaron J, Colquhoun, Samantha M, Coresh, Josef, Criqui, Michael H, Cromwell, Elizabeth A, Crump, John A, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, das Neves, José, Davey, Gail, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, De Leo, Diego, Degenhardt, Louisa, Deiparine, Selina, Dellavalle, Robert P, Deribe, Kebede, Deribew, Amare, Des Jarlais, Don C, Dey, Subhojit, Dharmaratne, Samath D, Dherani, Mukesh K, Diaz-Torné, Cesar, Ding, Eric L, Dixit, Priyanka, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Donnelly, Christl Ann, dos Santos, Kadine Priscila Bender, Douwes-Schultz, Dirk, Driscoll, Tim R, Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Dwivedi, Laxmi Kant, Ebrahimi, Hedyeh, El Bcheraoui, Charbel, Ellingsen, Christian Lycke, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshetie, Setegn, Eshrati, Babak, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Fanuel, Fanuel Belayneh Bekele, Faro, André, Farvid, Maryam S, Farzadfar, Farshad, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G, Fernandes, João C, Feyissa, Tesfaye Regassa, Filip, Irina, Fischer, Florian, Foigt, Nataliya, Foreman, Kyle J, Frank, Tahvi, Franklin, Richard C, Fraser, Maya, Friedman, Joseph, Frostad, Joseph J, Fullman, Nancy, Fürst, Thomas, Furtado, Joao M, Futran, Neal D, Gakidou, Emmanuela, Gambashidze, Ketevan, Gamkrelidze, Amiran, Gankpé, Fortuné Gbètoho, Garcia-Basteiro, Alberto L, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebrekidan, Kahsu Gebrekirstos, Gebremichael, Mengistu Welday, Gelaye, Amha Admasie, Geleijnse, Johanna M, Gemechu, Bikila Lencha, Gemechu, Kasiye Shiferaw, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W, Gibney, Katherine B, Gill, Paramjit Singh, Gillum, Richard F, Giref, Ababi Zergaw, Girma, Bedilu Weji, Giussani, Giorgia, Goenka, Shifalika, Gomez, Beatriz, Gona, Philimon N, Gopalani, Sameer Vali, Goulart, Alessandra Carvalho, Graetz, Nicholas, Gugnani, Harish Chander, Gupta, Prakash C, Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A, Hafezi-Nejad, Nima, Hakuzimana, Alex, Halasa, Yara A, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Roderick J, Hay, Simon I, He, Fei, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hilawe, Esayas Haregot, Hoek, Hans W, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J, Huang, Hsiang, Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ileanu, Bogdan Vasile, Inoue, Manami, Irenso, Asnake Ararsa, Irvine, Caleb M S, Islam, Sheikh Mohammed Shariful, Islam, Nazrul, Jacobsen, Kathryn H, Jaenisch, Thomas, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jin, Ye, John, Denny, John, Oommen, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimi, Seyed M, Karthikeyan, Ganesan, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Keiyoro, Peter Njenga, Kelbore, Sefonias Getachew, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Kesavachandran, Chandrasekharan Nair, Ketema, Ezra Belay, Khader, Yousef Saleh, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Kibret, Getiye Dejenu, Kieling, Christian, Kim, Yun Jin, Kim, Cho-il, Kim, Daniel, Kim, Pauline, Kim, Sungroul, Kimokoti, Ruth W, Kinfu, Yohannes, Kishawi, Sami, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael, Krohn, Kristopher J, Kuate Defo, Barthelemy, Kuipers, Ernst J, Kulikoff, Xie Rachel, Kulkarni, Veena S, Kumar, G Anil, Kumar, Pushpendra, Kumsa, Fekede Asefa, Kutz, Michael, Lachat, Carl, Lagat, Abraham K, Lager, Anton Carl Jonas, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Nkurunziza, Lan, Qing, Lansingh, Van C, Larson, Heidi J, Larsson, Anders, Laryea, Dennis Odai, Lavados, Pablo M, Laxmaiah, Avula, Lee, Paul H, Leigh, James, Leung, Janni, Leung, Ricky, Levi, Miriam, Li, Yongmei, Liao, Yu, Liben, Misgan Legesse, Lim, Stephen S, Linn, Shai, Lipshultz, Steven E, Liu, Shiwei, Lodha, Rakesh, Logroscino, Giancarlo, Lorch, Scott A, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lunevicius, Raimundas, Lyons, Ronan A, Ma, Stefan, Macarayan, Erlyn RachelleKing, Machado, Isis Eloah, Mackay, Mark T, Magdy Abd El Razek, Mohammed, Magis-Rodriguez, Carlos, Mahdavi, Mahdi, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Mantovani, Lorenzo G, Manyazewal, Tsegahun, Mapoma, Chabila C, Marczak, Laurie B, Marks, Guy B, Martin, Elena Alvarez, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Massano, João, Maulik, Pallab K, Mayosi, Bongani M, Mazidi, Mohsen, McAlinden, Colm, McGarvey, Stephen Theodore, McGrath, John J, McKee, Martin, Mehata, Suresh, Mehndiratta, Man Mohan, Mehta, Kala M, Meier, Toni, Mekonnen, Tefera Chane, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mengistu, Desalegn Tadese, Menon, Geetha R, Menota, Bereket Gebremichael, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Mezgebe, Haftay Berhane, Micha, Renata, Mikesell, Joseph, Miller, Ted R, Mills, Edward J, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Kedir Endris, Mohammed, Shafiu, Mohan, Murali B V, Mohanty, Sanjay K, Mokdad, Ali H, Mollenkopf, Sarah K, Molokhia, Mariam, Monasta, Lorenzo, Montañez Hernandez, Julio Cesar, Montico, Marcella, Mooney, Meghan D, Moore, Ami R, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Mori, Rintaro, Morrison, Shane D, Mruts, Kalayu Birhane, Mueller, Ulrich O, Mullany, Erin, Muller, Kate, Murthy, Gudlavalleti Venkata Satyanarayana, Murthy, Srinivas, Musa, Kamarul Imran, Nachega, Jean B, Nagata, Chie, Nagel, Gabriele, Naghavi, Mohsen, Naidoo, Kovin S, Nanda, Lipika, Nangia, Vinay, Nascimento, Bruno Ramos, Natarajan, Gopalakrishnan, Negoi, Ionut, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Ningrum, Dina Nur Anggraini, Nisar, Muhammad Imran, Nomura, Marika, Nong, Vuong Minh, Norheim, Ole F, Norrving, Bo, Noubiap, Jean Jacques N, Nyakarahuka, Luke, O'Donnell, Martin J, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew Toyin, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oren, Eyal, Ortiz, Alberto, Osgood-Zimmerman, Aaron, Ota, Erika, Owolabi, Mayowa O, Oyekale, Abayomi Samuel, PA, Mahesh, Pacella, Rosana E, Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Park, Eun-Kee, Parsaeian, Mahboubeh, Patel, Tejas, Patten, Scott B, Patton, George C, Paudel, Deepak, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie Beth, Petri, William Arthur, Petzold, Max, Phillips, Michael Robert, Piel, Frédéric B, Pigott, David M, Pishgar, Farhad, Plass, Dietrich, Polinder, Suzanne, Popova, Svetlana, Postma, Maarten J, Poulton, Richie G, Pourmalek, Farshad, Prasad, Narayan, Purwar, Manorama, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Rabiee, Rynaz H S, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rana, Saleem M, Ranabhat, Chhabi Lal, Rao, Paturi Vishnupriya, Rawaf, Salman, Ray, Sarah E, Rego, Maria Albertina Santiago, Rehm, Jürgen, Reiner, Robert C, Remuzzi, Giuseppe, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Satar, Rezai, Mohammad Sadegh, Ribeiro, Antonio L, Rivas, Jacqueline Castillo, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Roy, Ambuj, Rubagotti, Enrico, Ruhago, George Mugambage, Saadat, Soheil, Sabde, Yogesh Damodar, Sachdev, Perminder S, Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salama, Joseph, Salamati, Payman, Salomon, Joshua A, Salvi, Sundeep Santosh, Samy, Abdallah M, Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolores, Santos, Itamar S, Santric Milicevic, Milena M, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Sawhney, Monika, Saxena, Sonia, Saylan, Mete I, Schmidt, Maria Inês, Schneider, Ione J C, Schulhofer-Wohl, Sam, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Seedat, Soraya, Seid, Abdulbasit Musa, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya Anne, Shaheen, Amira, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Shen, Jiabin, Shetty, Balakrishna P, Shi, Peilin, Shibuya, Kenji, Shifa, Girma Temam, Shigematsu, Mika, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G, Sigfusdottir, Inga Dora, Silberberg, Donald H, Silpakit, Naris, Silva, Diego Augusto Santos, Silva, João Pedro, Silveira, Dayane Gabriele Alves, Sindi, Shireen, Singh, Jasvinder A, Singh, Prashant Kumar, Singh, Abhishek, Singh, Virendra, Sinha, Dhirendra Narain, Skarbek, Katarzyna A Kissimova-, Skiadaresi, Eirini, Sligar, Amber, Smith, David L, Sobaih, Badr H A, Sobngwi, Eugene, Soneji, Samir, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J, Steiner, Caitlyn, Stöckl, Heidi, Stokes, Mark Andrew, Strong, Mark, Sufiyan, Muawiyyah Babale, Suliankatchi, Rizwan Abdulkader, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Tadese, Fentaw, Tandon, Nikhil, Tanne, David, Tarajia, Musharaf, Tavakkoli, Mohammad, Taveira, Nuno, Tehrani-Banihashemi, Arash, Tekelab, Tesfalidet, Tekle, Dejen Yemane, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Tesema, Cheru Leshargie, Tesssema, Belay, Theis, Andrew, Thomas, Nihal, Thompson, Alex H, Thomson, Alan J, Thrift, Amanda G, Tiruye, Tenaw Yimer, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tortajada, Miguel, Tran, Bach Xuan, Truelsen, Thomas, Trujillo, Ulises, Tsilimparis, Nikolaos, Tuem, Kald Beshir, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Undurraga, Eduardo A, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, van Boven, Job F M, Varakin, Yuri Y, Varughese, Santosh, Vasankari, Tommi, Vasconcelos, Ana Maria Nogales, Velasquez, Ilais Moreno, Venketasubramanian, Narayanaswamy, Vidavalur, Ramesh, Violante, Francesco S, Vishnu, Abhishek, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Waid, Jillian L, Wakayo, Tolassa, Wang, Yuan-Pang, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wesana, Joshua, Wijeratne, Tissa, Wilkinson, James D, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D A, Workicho, Abdulhalik, Workie, Shimelash Bitew, Xavier, Denis, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yimam, Hassen Hamid, Yip, Paul, Yirsaw, Biruck Desalegn, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Lopez, Alan D, and Murray, Christopher J L

Abstract

Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016.

Published
2017
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220. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Naghavi, Mohsen, Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Miloud Taki Eddine, Aichour, Ibtihel, Aiyar, Sneha, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Baune, Bernhard T, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Boris, Bisanzio, Donal, Bourne, Rupert R A, Breitborde, Nicholas J K, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Car, Josip, Cárdenas, Rosario, Carrero, Juan Jesus, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charlson, Fiona J, Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G, Cirillo, Massimo, Cohen, Aaron J, Colombara, Danny, Cooper, Cyrus, Cowie, Benjamin C, Criqui, Michael H, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, das Neves, José, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, Defo, Barthelemy Kuate, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R, Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Ermakov, Sergey Petrovich, Erskine, Holly E, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Farinha, Carla Sofia e Sa, Faro, André, Farzadfar, Farshad, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C, Ferrari, Alize J, Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D, Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Fürst, Thomas, Furtado, Joao M, Gakidou, Emmanuela, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W, Gillum, Richard F, Giref, Ababi Zergaw, Giroud, Maurice, Giussani, Giorgia, Godwin, William W, Gold, Audra L, Goldberg, Ellen M, Gona, Philimon N, Gopalani, Sameer Vali, Gouda, Hebe N, Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Gupta, Parkash C, Haagsma, Juanita A, Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Simon I, He, Fei, Hedayati, Mohammad T, Henry, Nathaniel J, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, André, Karimi, Seyed M, Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Khosravi, Ardeshir, Khubchandani, Jagdish, Kiadaliri, Aliasghar Ahmad, Kieling, Christian, Kievlan, Daniel, Kim, Yun Jin, Kim, Daniel, Kimokoti, Ruth W, Kinfu, Yohannes, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kulikoff, Xie Rachel, Kumar, G Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Tea Lallukka Nkurunziza, Lan, Qing, Lansingh, Van C, Larsson, Anders, Lee, Paul H, Leigh, James, Leung, Janni, Levi, Miriam, Li, Yongmei, Li Kappe, Darya, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S, Liu, Patrick Y, Liu, Angela, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Timothy C D, Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R, Magdy Abd El Razek, Mohammed, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C, Marczak, Laurie B, Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mohamed, Ibrahim Abdelmageem, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H, Mola, Glen Liddell D, Mollenkopf, Sarah K, Molokhia, Mariam, Monasta, Lorenzo, Montañez, Julio C, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morozoff, Chloe, Morrison, Shane D, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramos, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Noubiap, Jean Jacques N, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, PA, Mahesh, Pacella, Rosana E, Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pereira, David M, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M, Pinho, Christine, Plass, Dietrich, Pletcher, Martin A, Polinder, Suzanne, Postma, Maarten J, Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C, Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E, Rehm, Jürgen, Reiner, Robert C, Reitsma, Marissa B, Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Ruhago, George Mugambage, SA, Rizwan, Saadat, Soheil, Sachdev, Perminder S, Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A, Samy, Abdallah M, Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolores, Santomauro, Damian, Santos, Itamar S, Santric Milicevic, Milena M, Sartorius, Benn, Satpathy, Maheswar, Schmidt, Maria Inês, Schneider, Ione J C, Schulhofer-Wohl, Sam, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya Anne, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shi, Peilin, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G, Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, João Pedro, Singh, Jasvinder A, Singh, Abhishek, Skiadaresi, Eirini, Sligar, Amber, Smith, David L, Smith, Alison, Smith, Mari, Sobaih, Badr H A, Soneji, Samir, Sorensen, Reed J D, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J, Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S, Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J S, Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E, Thompson, Alex H, Thomson, Alan J, Thrift, Amanda G, Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N, Undurraga, Eduardo A, Updike, Rachel, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, van Boven, Job F M, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T, Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A, Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D A, Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Denis, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Lopez, Alan D, and Murray, Christopher J L

Abstract

Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends.

Published
2017
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226. Walk Score® and the prevalence of utilitarian walking and obesity among Ontario adults: A cross-sectional study.

Author

Chiu, Maria, Shah, Baiju R., Maclagan, Laura C., Rezai, Mohammad-Reza, Austin, Peter C., and Tu, Jack V.

Subjects
OBESITY, OVERWEIGHT persons, PHYSICAL activity, POPULATION health, HEALTH surveys
Abstract

Background: Evidence from large, population-based studies about the association between neighbourhood walkability and the prevalence of obesity is limited. Data and methods: The study population consisted of 106,337 people aged 20 or older living in urban and suburban Ontario, who participated in the National Population Health Survey and the Canadian Community Health Survey from 1996/1997 to 2008. Based on their postal code, individuals were grouped into one of five walkability categories, ranging from very car-dependent to "Walker's Paradise," according to the Street Smart Walk Score®, a composite measure of neighbourhood walkability. Logistic regression models, adjusted for demographic, socioeconomic and lifestyle characteristics, were used to estimate odds ratios relating neighbourhood walkability to overweight/obesity and physical activity. Results: Compared with residents of "Walker's Paradise" areas, those in very car-dependent areas had significantly higher odds of being overweight or obese. Despite similar levels of leisure physical activity among residents of all walkability areas, those in "Walker's Paradise" areas reported more utilitarian walking and weighed, on average, 3.0 kg less than did those in very car-dependent areas. Interpretation: Living in a low-walkability area is associated with a higher prevalence of overweight/obesity. Neighbourhood walkability is related to the frequency of utilitarian walking. [ABSTRACT FROM AUTHOR]

Published
2015

227. Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran.

Author

Rezai, Mohammad Sadegh, Salehifar, Ebrahim, Rafiei, Alireza, Langaee, Taimour, Rafati, Mohammadreza, Shafahi, Kheironesa, and Eslami, Gohar

Subjects
*URINE microbiology, *DNA, *DRUG resistance in microorganisms, *ESCHERICHIA coli, *GENES, *POLYMERASE chain reaction, *RESEARCH funding, *GENOTYPES
Abstract

Escherichia coli remains as one of the most important bacteria causing infections in pediatrics and producing extended-spectrum beta-lactamases (ESBLs) making them resistant to beta-lactam antibiotics. In this study we aimed to genotype ESBL-producing E. coli isolates from pediatric patients for ESBL genes and determine their association with antimicrobial resistance. One hundred of the E. coli isolates were initially considered ESBL producing based on their MIC results. These isolates were then tested by polymerase chain reaction (PCR) for the presence or absence of CTX, TEM, SHV, GES, and VEB beta-lactamase genes. About 30.5% of isolated E. coli was ESBL-producing strain. The TEM gene was the most prevalent (49%) followed by SHV (44%), CTX (28%), VEB (8%), and GES (0%) genes. The ESBL-producing E. coli isolates were susceptible to carbapenems (66%) and amikacin (58%) and showed high resistance to cefixime (99%), colistin (82%), and ciprofloxacin (76%). In conclusion, carbapenems were the most effective antibiotics against ESBl-producing E. coli in urinary tract infection in North of Iran. The most prevalent gene is the TEM-type, but the other resistant genes and their antimicrobial resistance are on the rise. [ABSTRACT FROM AUTHOR]

Published
2015
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228. Accounting for English article interpretation by L2 speakers

Author

Hawkins, Roger, primary, Al-Eid, Saleh, additional, Almahboob, Ibrahim, additional, Athanasopoulos, Panos, additional, Chaengchenkit, Rangsiya, additional, Hu, James, additional, Rezai, Mohammad, additional, Jaensch, Carol, additional, Jeon, Yunju, additional, Jiang, Amy, additional, Leung, Yan-kit Ingrid, additional, Matsunaga, Keiko, additional, Ortega, Martha, additional, Sarko, Ghisseh, additional, Snape, Neal, additional, and Velasco-Zárate, Kalinka, additional

Published
2006
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230. Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.

Author

Motamedi, Radineh, Shafiee, Abbas, Rezai, Mohammad Reza, Firuzi, Omidreza, Edraki, Najmeh, and Miri, Ramin

Subjects
AROMATIZATION, OXIDATIVE stress, CYTOTOXIC T cells, QUINOLINE, CHEMICAL derivatives
Abstract

In the present work, novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7Hchromeno[ 4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/NaNO2 with yields of 64-74%. Cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (K562, LS180, and MCF-7). Synthesized compounds showed moderate cytotoxic activities. The most active one apeared to be 2e, containing a methoxy group on the meta position of phenyl ring (IC50 range in different cell lines: 11.1-55.7 μM). Furthermore; comparison of the cytotoxic activity of these novel oxidized derivatives with non-oxidized counterparts revealed that oxidation of dihydropyridine ring to pyridine, improves the activity especially in LS180 cell line. Conformational analysis revealed that some conformational aspects of oxidized derivatives such as orientation of C7-aryl substitute were clearly different from non-oxidized ones [ABSTRACT FROM AUTHOR]

Published
2014

232. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial.

Author

Abbaskhanian, Ali, Ehteshami, Sara, Sajjadi, Sadegh, and Rezai, Mohammad Sadegh

Abstract

Objective: Breath holding spells (BHS) are common paroxysmal non-epileptic events in the pediatric population which are very stressfull despite their harmless nature. There has been no specific treatment found for the spells yet. The aim of this study was to evaluate the efficacy of piracetam (2-oxo-l-pyrrolidine) on these children. Materials & Methods: In this randomized double blind clinical trial study, 150 children with severe BHS referred to our pediatric outpatient service were enrolled from August 2011 to July 2012. The patients were randomized into two equal groups. One received 40mg/kg/day piracetam and the other group received placebo, twice daily. Patients were followed monthly for three months. The number of attacks/month before and after treatment were documented. Results: Of the enrolled patients, 86 were boys. The mean age of the patients was 17 months (range, 6 to 24 months). In the piracetam group, 1 month after treatment an 81% response to treatment was found. In the placebo group, none of the patients had complete remission and 7% of the cases had partial remission. Overall, control of breath-holding spells was observed in 91% of the patients in the group taking piracetam as compared with 16% in the group taking placebo at the end of the study. There was no significant difference detected between the groups regarding the prevalence of drug side effects. Conclusion: A significant difference was detected between piracetam and placebo in prevention and controlling BHS. Piracetam (40mg/kg/day) had a good effect on our patients. [ABSTRACT FROM AUTHOR]

Published
2012

233. Acute Disseminated Encephalomyelitis: An Unusual Presentation.

Author

Rezai, Mohammad Sadegh, Bahari, Amir, and Abbaskhanian, Ali

Subjects
*POSTVACCINAL encephalitis, *DEMYELINATION, *ETIOLOGY of diseases, *INTRAVENOUS therapy, *IMMUNOGLOBULINS, *PLASMAPHERESIS, *CONSCIOUSNESS, *DIAGNOSIS
Abstract

The acute disseminated encephalomyelitis (ADEM) is a rare, monophasic or multiphasic demyelinating disease influencing the central nervous system with almost unknown etiology. The diagnosis is based on clinical picture, supported by radiology and laboratory tests. The common therapeutic approach includes administrating corticosteroids, intravenous immunoglobulin (IVIG), and plasmapheresis. This paper reports a 24-month-old normal boy admitted with fever and vomiting preceded by intermittent irritability from two days earlier. We performed sonography while we were suspicious to invagination but found normal results. The patient had impaired consciousness, behavioral changes and irritability. He also had herpes lesions so he was treated with acyclovir. In the next day he had left esotropia. Lumbar puncture and electroencephalography were done which showed normal results. Then, MRI was performed and revealed ADEM. Intrvenous immunoglobulin (400 mg/kg) intravenously was started. At the end of the treatment he was afebrile with good general condition. [ABSTRACT FROM AUTHOR]

Published
2012

234. Investigating the Relationship between Eosinophilia and Coronary Artery Disease in Patients with Kawasaki Disease.

Author

Sadegh Rezai, Mohammad, Shokohi, Leila, Jafar Saffar, Mohammad, Zeinali, Aida, and Abbaskhanian, Ali

Subjects
*EOSINOPHILIA, *MUCOCUTANEOUS lymph node syndrome, *CHILD patients, *DIAGNOSIS, *CORONARY disease, *CORONARY heart disease risk factors, *MEDICAL research, *PATIENTS
Abstract

Background and purpose: Kawasaki disease (KD) is an acute vasculitis in children. Studies indicated different relationships between eosinophilia and coronary artery disease (CAD). This study was done to assess the possible relationship between eosinophilia and coronary artery disease. Materials and methods: This descriptive study was carried out during 13 years on 61 children with Kawasaki disease who were admitted to Sina Referral Hospital. They were assessed regarding eosinophilia and coronary artery diseases. Data was evaluated by Fisher exact and t-test. Results: The research population included 61 patients of whom 33 (54%) were male and 28 (46%) were female with the mean age of 36.56 ± 23 months. Among the patients 85% were >5 years of age and eosinophilia was found in 28 cases (45.9%) and five patients (14.8%) were diagnosed with coronary artery disease. This disease was observed in 25% suffering from eosinophilia and in 6% of the cases without eosinophilia. However, there was no association among gender, eosinophilia and coronary artery disease. Also, no significant difference was found between age groups. Conclusion: Eosinophilia was not a risk factor or protective factor for CAD. However, the exact relationship could be determined if further multicentre studies are carried out. [ABSTRACT FROM AUTHOR]

Published
2012

235. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Naghavi, Mohsen, Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Arnlov, Johan, Afshin, Ashkan, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Aiyar, Sneha, Al-Eyadhy, Ayman, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addis, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M., Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H., Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T., Anwari, Palwasha, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W., Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Paulina, Beatriz, Quintanilla, Ayala, Bejot, Yannick, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A., Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lars, Barrero, Lope H., Baune, Bernhard T., Bedi, Neeraj, Beghi, Ettore, Bekele, Bayu Begashaw, Bell, Michelle L., Bennett, James R., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Boris, Bisanzio, Donal, Bourne, Rupert R. A., Breitborde, Nicholas J. K., Negesa, Lemma, Bulto, Bulto, Bumgarner, Blair R., Butt, Zahid A., Cardenas, Rosario, Cahuana-Hurtado, Lucero, Cameron, Ewan, Cesar Campuzano, Julio, Car, Josip, Jesus Carrero, Juan, Carter, Austin, Casey, Daniel C., Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Charlson, Fiona J., Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Colombara, Danny, Cooper, Cyrus, Cowie, Benjamin C., Criqui, Michael H., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., das Neves, Jose, Davitoiu, Dragos V., Davletov, Kairat, de Courten, Barbora, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L., Djalalinia, Shirin, Huyen Phuc Do, Huyen Phuc Do, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R., Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Erskine, Holly E., Eskandarieh, Sharareh, Esteghamati, Alireza, Ermakov, Sergey P., Estep, Kara, E Sa Farinha, Carla Sofia, Faro, Andre, Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Joao C., Ferrari, Alize J., Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D., Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Furst, Thomas, Furtado, Joao M., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M., Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W., Gillum, Richard F., Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Giussani, Giorgia, Godwin, William W., Gold, Audra L., Goldberg, Ellen M., Gona, Philimon N., Gopalani, Sameer Vali, Gouda, Hebe N., Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Prakash C., Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Simon I., He, Fei, Hedayati, Mohammad T., Henry, Nathaniel J., Beatriz Heredia-Pi, Ileana, Herteliu, Claudiu, Hoek, Hans W., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Jurisson, Mikk, Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayaraman, Sudha P., Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O., Johnson, Sarah Charlotte, Jonas, Jost B., Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, Andre, Karimi, Seyed M., Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kieling, Christian, Kievlan, Daniel, Kim, Daniel, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A., Kosen, Soewarta, Koul, Parvaiz A., Koyanagi, Ai, Defo, Barthelemy Kuate, Kulikoff, Xie Rachel, Kumar, G. Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lambert, Nkurunziza, Lan, Qing, Lansingh, Van C., Larsson, Anders, Lee, Paul H., Leigh, James, Leung, Janni, Levi, Miriam, Li, Yongmei, Kappe, Darya Li, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S., Liu, Angela, Liu, Patrick Y., Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lucas, Timothy C. D., Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R., Abd el Razek, Mohammed Magdy, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C., Marczak, Laurie B., Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J., Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A., Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A., Meretoja, Atte, Meretoja, Tuomo J., Millear, Anoushka, Miller, Ted R., Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M., Misganaw, Awoke, Mishra, Shiva Raj, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H., Mola, Glen Liddell D., Mollenkopf, Sarah K., Molokhia, Mariam, Monasta, Lorenzo, Montanez Hernandez, Julio C., Montico, Marcella, Mooney, Meghan D., Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morrison, Shane D., Morozoff, Chloe, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B., Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramos, Nasher, Jamal T., Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Cuong Tat Nguyen, Cuong Tat Nguyen, Grant Nguyen, Grant Nguyen, Minh Nguyen, Minh Nguyen, Quyen Le Nguyen, Quyen Le Nguyen, Trang Huyen Nguyen, Trang Huyen Nguyen, Nichols, Emma, Ningrum, Dina Nur Anggraini, Vuong Minh Nong, Vuong Minh Nong, Noubiap, Jean Jacques N., Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Pa, Mahesh, Pacella, Rosana E., Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B., Patton, George C., Paudel, Deepak, Paulson, Katherine, Pereira, David M., Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M., Pinho, Christine, Plass, Dietrich, Pletcher, Martin A., Polinder, Suzanne, Postma, Maarten J., Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C., Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E., Rehm, Jurgen, Reiner, Robert C., Reitsma, Marissa B., Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Ruhago, George Mugambage, Saadat, Rizwan S. A. Soheil, Sachdev, Perminder S., Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A., Samy, Abdallah M., Sanabria, Juan Ramon, Dolores Sanchez-Nino, Maria, Santomauro, Damian, Santos, Itamar S., Milicevic, Milena M. Santric, Sartorius, Benn, Satpathy, Maheswar, Shahraz, Saeid, Schmidt, Maria Ines, Schneider, Ione J. C., Schulhofer-Wohl, Sam, Schutte, Aletta E., Schwebel, David C., Schwendicke, Falk, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya Anne, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Islam, Sheikh Mohammed Shariful, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shi, Peilin, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G., Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, Joao Pedro, Singh, Abhishek, Singh, Jasvinder A., Skiadaresi, Eirini, Sligar, Amber, Smith, Alison, Smith, David L., Smith, Mari, Sobaih, Badr H. A., Soneji, Samir, Sorensen, Reed J. D., Soriano, Joan B., Sreeramareddy, Chandrashekhar T., Srinivasan, Vinay, Stanaway, Jeffrey D., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F., Sur, Patrick J., Swaminathan, Soumya, Sykes, Bryan L., Tabares-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S., Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J. S., Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E., Thompson, Alex H., Thomson, Alan J., Thrift, Amanda G., Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Bach Xuan Tran, Bach Xuan Tran, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Updike, Rachel, Uthman, Olalekan A., Uzochukwu, Benjamin S. Chudi, van Boven, Job F. M., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T., Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G., Weiss, Daniel J., Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A., Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D. A., Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Denis, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Lopez, Alan D., Murray, Christopher J. L., Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Miloud Taki Eddine, Aichour, Ibtihel, Aiyar, Sneha, Alahdab, Fare, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addi, Al-Eyadhy, Ayman, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, Françoi, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lar, Barrero, Lope H, Baune, Bernhard T, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Bori, Bisanzio, Donal, Bourne, Rupert R A, Breitborde, Nicholas J K, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Car, Josip, Cárdenas, Rosario, Carrero, Juan Jesu, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charlson, Fiona J, Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Christopher, Devasahayam Jesuda, Ciobanu, Liliana G, Cirillo, Massimo, Cohen, Aaron J, Colombara, Danny, Cooper, Cyru, Cowie, Benjamin C, Criqui, Michael H, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, das Neves, José, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, Defo, Barthelemy Kuate, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R, Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Erskine, Holly E, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Farinha, Carla Sofia e Sa, Faro, André, Farzadfar, Farshad, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C, Ferrari, Alize J, Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D, Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Fürst, Thoma, Furtado, Joao M, Gakidou, Emmanuela, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W, Gillum, Richard F, Giroud, Maurice, Giussani, Giorgia, Godwin, William W, Gold, Audra L, Goldberg, Ellen M, Gona, Philimon N, Gopalani, Sameer Vali, Gouda, Hebe N, Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A, Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmu, Hay, Simon I, He, Fei, Hedayati, Mohammad T, Henry, Nathaniel J, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, André, Karimi, Seyed M, Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Khosravi, Ardeshir, Khubchandani, Jagdish, Kiadaliri, Aliasghar Ahmad, Kieling, Christian, Kievlan, Daniel, Kim, Yun Jin, Kim, Daniel, Kimokoti, Ruth W, Kinfu, Yohanne, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kulikoff, Xie Rachel, Kumar, G Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Tea Lallukka Nkurunziza, Lan, Qing, Lansingh, Van C, Larsson, Ander, Lee, Paul H, Leigh, Jame, Leung, Janni, Levi, Miriam, Li, Yongmei, Li Kappe, Darya, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S, Liu, Patrick Y, Liu, Angela, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Timothy C D, Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R, Magdy Abd El Razek, Mohammed, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C, Marczak, Laurie B, Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mohamed, Ibrahim Abdelmageem, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H, Mola, Glen Liddell D, Mollenkopf, Sarah K, Molokhia, Mariam, Monasta, Lorenzo, Montañez, Julio C, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morozoff, Chloe, Morrison, Shane D, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murray, Christopher J L, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B, Naghavi, Mohsen, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramo, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Noubiap, Jean Jacques N, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, PA, Mahesh, Pacella, Rosana E, Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pereira, David M, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M, Pinho, Christine, Plass, Dietrich, Pletcher, Martin A, Polinder, Suzanne, Postma, Maarten J, Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Radfar, Amir, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C, Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E, Rehm, Jürgen, Reiner, Robert C, Reitsma, Marissa B, Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Ruhago, George Mugambage, SA, Rizwan, Saadat, Soheil, Sachdev, Perminder S, Sadat, Nafi, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A, Samy, Abdallah M, Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolore, Santomauro, Damian, Santos, Itamar S, Santric Milicevic, Milena M, Sartorius, Benn, Satpathy, Maheswar, Schmidt, Maria Inê, Schneider, Ione J C, Schulhofer-Wohl, Sam, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya Anne, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G, Sigfusdottir, Inga Dora, Silpakit, Nari, Silva, João Pedro, Singh, Jasvinder A, Singh, Abhishek, Skiadaresi, Eirini, Sligar, Amber, Smith, David L, Smith, Alison, Smith, Mari, Sobaih, Badr H A, Soneji, Samir, Sorensen, Reed J D, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steel, Nichola, Stein, Dan J, Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S, Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J.S., Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E, Thompson, Alex H, Thomson, Alan J, Thrift, Amanda G, Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thoma, Tsoi, Derrick, Tyrovolas, Stefano, Ukwaja, Kingsley N, Undurraga, Eduardo A, Updike, Rachel, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, van Boven, Job F M, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T, Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A, Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D A, Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Deni, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Giref, Ababi Zergaw, Rafay, Anwar, Tuzcu, Emin Murat, Ermakov, Sergey Petrovich, Shi, Peilin, Gupta, Parkash C, Erasmus MC other, Public Health, Neurosciences, Viðskiptadeild (HR), School of Business (RU), Háskólinn í Reykjavík, Reykjavik University, Mohsen, Naghavi, Amanuel, Alemu, Abajobir, Cristiana, Abbafati, Kaja, M, Abbas, Foad, Abd Allah, Semaw, Ferede, Abera, Victor, Aboyan, Olatunji, Adetokunboh, Johan, Ärnlöv, Ashkan, Afshin, Anurag, Agrawal, Aliasghar, Ahmad, Kiadaliri, Alireza, Ahmadi, Muktar, Beshir, Ahmed, Amani, Nidhal, Aichour, Ibtihel, Aichour, Miloud, Taki, Eddine, Aichour, Sneha, Aiyar, Ayman, Al Eyadhy, Fares, Alahdab, Ziyad, Al Aly, Khurshid, Alam, Noore, Alam, Tahiya, Alam, Kefyalew, Addi, Alene, Syed, Danish, Ali, Reza, Alizadeh Navaei, Juma, M, Alkaabi, Ala’A, Alkerwi, François, Alla, Peter, Allebeck, Christine, Allen, Rajaa, Al Raddadi, Ubai, Alsharif, Khalid, A, Altirkawi, Nelson, Alvis Guzman, Azmeraw, T, Amare, Erfan, Amini, Walid, Ammar, Yaw, Ampem, Amoako, Nahla, Anber, Hjalte, H, Andersen, Catalina, Liliana, Andrei, Sofia, Androudi, Hossein, Ansari, Carl, Abelardo, T, Antonio, Palwasha, Anwari, Megha, Arora, Al, Artaman, Krishna, Kumar, Aryal, Hamid, Asayesh, Solomon, W, Asgedom, Tesfay, Mehari, Atey, Leticia, Avila Burgo, Euripide, Frinel, G, Arthur, Avokpaho, Ashish, Awasthi, Beatriz, Paulina, Ayala, Quintanilla, Yannick, Béjot, Tesleem, Kayode, Babalola, Umar, Bacha, Kalpana, Balakrishnan, Aleksandra, Barac, Miguel, A, Barboza, Suzanne, L, Barker, Collo, Simon, Barquera, Lars, Barregard, Lope, H, Barrero, Bernhard, T, Baune, Neeraj, Bedi, Ettore, Beghi, Bayu, Begashaw, Bekele, Michelle, L, Bell, James, R, Bennett, Isabela, M, Bensenor, Adugnaw, Berhane, Eduardo, Bernabé, Balem, Demtsu, Betsu, Mircea, Beuran, Samir, Bhatt, Sibhatu, Biadgilign, Kelly, Bienhoff, Boris, Bikbov, Donal, Bisanzio, Rupert, R, A, Bourne, Nicholas, J, K, Breitborde, Lemma, Negesa, Bulto, Bulto, Blair, R, Bumgarner, Zahid, A, Butt, Rosario, Cárdena, Lucero, Cahuana Hurtado, Ewan, Cameron, Julio, Cesar, Campuzano, Josip, Car, Juan, Jesu, Carrero, Austin, Carter, Daniel, C, Casey, Carlo, A, Castañeda, Orjuela, Ferrán, Catalá López, Fiona, J, Charlson, Chioma, Ezinne, Chibueze, Odgerel, Chimed Ochir, Vesper, Hichilombwe, Chisumpa, Abdulaal, A, Chitheer, Devasahayam, Jesuda, Christopher, Liliana, G, Ciobanu, Aaron, J, and Cohen

Subjects
Dánarmein, Male, Heilsufar, Dánartíðni, Newborn infants, Lífslíkur, Life expectancy, Communicable diseases, Global Health, Global Burden of Disease, Disasters, Pregnancy, Cause of Death, Psychology, Child, Konur, Aged, 80 and over, Ungbörn, CLIMATE-CHANGE, PLASMODIUM-FALCIPARUM, Kransæðasjúkdómar, Global burden of disease/statistics and numerical data, Medicine (all), Men, Þjóðir, Öndunarfærasjúkdómar, 11 Medical And Health Sciences, Middle Aged, Nutrition Disorders, PREVALENCE, Coronary heart disease, Smitsjúkdómar, Death, Suicide, Cardiovascular diseases, Sálfræði, World health, Child, Preschool, Nýburar, Female, GBD, mortality, Infants, Life Sciences & Biomedicine, Age distribution, Global Health Metrics, Adult, Diarrhea, AFRICA, HUMAN HEALTH, Adolescent, GBD, UNITED-STATES, Socioeconomic factors, Communicable Diseases, Young Adult, Age Distribution, Heilbrigðisvísindi, Medicine, General & Internal, General & Internal Medicine, Humans, QUALITY, Women, Nutrition disorders, INCOME COUNTRIES, Mortality, Noncommunicable Diseases, Aged, Science & Technology, Infant, Newborn, Infant, Respiratory infections, Næringarskortur, ALCOHOL POLICY, mortality, Malaria, Pregnancy Complications, Socioeconomic Factors, Áverkar, Karlar, Wounds and Injuries, Félagshagfræði, Accidental Falls, Cause of death/trends, RESISTANCE
Abstract

Correction: Group Author(s): GBD 2016 Causes Death LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017 Group Author(s): GBD 2016 Dis Injury Incidence LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specific causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specific deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72.3% (95% uncertainty interval [UI] 71.2-73.2) of deaths in 2016 with 19.3% (18.5-20.4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8.43% (8.00-8.67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16-age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1.80 million deaths (95% UI 1.59 million to 1.89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL significantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2.89%); the median annualised rate of change for all other causes was lower (a decrease of 1.59%) during the same interval. Globally, the five leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a finer level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and conflict and terrorism. Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially increasing costs to health systems., Bill & Melinda Gates Foundation.

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236. Ciprofloxacin for treatment of drug-resistant epilepsy.

Author

Cheraghmakani, Hamed, Rezai, Mohammad Sadegh, Valadan, Reza, Rahimzadeh, Golnar, Moradi, Mona, Jahanfekr, Vahid, Moosazadeh, Mahmood, and Tabrizi, Nasim

Subjects
*EPILEPSY, *CIPROFLOXACIN, *GUT microbiome, *ADULTS, *ANTICONVULSANTS
Abstract

• Gut -brain axis plays an important role in patients with epilepsy. • Short-term treatment with ciprofloxacin could improve dysbiosis. • Treatment by ciprofloxacin could reduce seizure frequency in drug resistant epilepsy. To investigate the efficacy of short-term treatment with ciprofloxacin in alteration of gut microbiota pattern and reduction of seizure frequency in adult patients with drug-resistant epilepsy. In a prospective study, we investigated the effect of a 5-day course of treatment with ciprofloxacin on gut microbiota pattern and seizure frequency of 23 adults with drug-resistant epilepsy. Fecal samples were collected before and after treatment and were analyzed for microbial load and species. Changes in seizure frequency were registered for 12 weeks. Responders were defined as patients who experienced ≥50 % seizure reduction in comparison to baseline. Outcome measures were specified as alteration in fecal microbial burden in days 5–7 and responder rate in 4th and 12th weeks. The mean baseline frequency of seizures was5.6 ±7.7 per week. All patients were on polytherapy with a mean of 3 ± 1.2 anti-seizure medications. Microbial analysis showed a considerable increase in Bacteroidetes/Firmicutes ratio after treatment. Seizure frequency significantly decreased at the end of first week and the therapeutic effect continued to week 12 (P < 0.001). The responder rate at 4th and 12th weeks were 69.6 % and 73.9 % respectively with a more prominent response in patients with symptomatic generalized epilepsy (P:0.06). Alteration of abnormal gut microbiota pattern by methods such as short-course antibiotic therapy, prescription of probiotics and fecal microbiota transplant might be effective in treatment of drug-resistant epilepsy. [ABSTRACT FROM AUTHOR]

Published
2021
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237. Tuberculosis Meningitis in a 9‐Month‐Old Girl during the COVID‐19 Pandemic.

Author

Bordbari, Amir-Hassan, Sheidaee, Kobra, Hajialibeig, Azin, Navaeifar, Mohammad Reza, Gooran, Maedeh, Rezai, Mohammad Sadegh, and Mégarbane, Bruno

Subjects
*PHYSICAL diagnosis, *BLOOD testing, *HEMIPLEGIA, *BRAIN, *COMPUTED tomography, *TREATMENT effectiveness, *MAGNETIC resonance imaging, *EMERGENCY medical services, *ANTITUBERCULAR agents, *EPILEPSY, *MAGNETIC resonance angiography, *VOMITING, *COVID-19 pandemic
Abstract

Tuberculous meningitis (TBM) is a serious form of TB disease that can result in high morbidity and mortality, particularly if there are delays in diagnosis and treatment. In this case report, a 9‐month‐old girl was admitted with persistent vomiting and focal seizures. On examination, she was found to have a right‐side hemiparesis. Brain imaging showed intense nodular leptomeningeal enhancement, hydrocephalus, a hypolucent lesion in the left basal ganglia, arterial stenosis and vasculitis, and an old ischemic insult. The patient was initially diagnosed with an acute ischemic stroke and was treated with aspirin and antiepileptic drugs. The patient's condition failed to improve despite initial treatment, leading to further diagnostic procedures. The results uncovered a diagnosis of TBM. The case highlights the importance of considering TBM as a possible cause of neurological symptoms, especially during the coronavirus disease 2019 (COVID‐19) pandemic where similar symptoms can be present in cases of neurological complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and multisystem inflammatory syndrome in children (MIS‐C). [ABSTRACT FROM AUTHOR]

Published
2024
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238. COVID-19 in Coincidence with Transient Distal Renal Tubular Acidosis in an Infant

Author

Razavi-Amoli, Seyedeh-Kiana, Mohammadjafari, Hamid, Zamanfar, Daniel, Reza Navaeifar, Mohammad, Sadati-Lamradi, Zahra, and Sadegh Rezai, Mohammad

Abstract

Background. Post-COVID-19 nephropathies have been reported profusely in the literature with diverse pathophysiological mechanisms. To the best of our knowledge, this is the first report of transient distal (type 1) renal tubular acidosis (dRTA) in an infant with confirmed COVID-19. Case Presentation. We describe a 32-day-old female with diarrhea and fever without respiratory complaints. Her weight, height, and head circumference were normal for age. The primary lab test showed leukocytosis, neutrophilia, elevated inflammatory markers, and non-anion-gap metabolic acidosis. Real-time polymerase chain reaction (RT-PCR) and elevated SARS-CoV-2 immunoglobulin M confirmed COVID-19, while echocardiography and spiral chest computed tomography scan were normal. Intravenous fluid therapy and supportive care were initiated. Blood culture was positive for Klebsiella pneumoniae. Amikacin and cefotaxime were ordered. Although diarrhea and dehydration gradually improved, venous blood gas still showed metabolic acidosis. Due to the alkaline urine and hypokalemic-hyperchloremic metabolic acidosis, dRTA was diagnosed. Notably, the patient dramatically responded to Shohl’s solution. Conclusions. Regarding the various manifestations of COVID-19, the possible association between dRTA and COVID-19 needs further investigation in children.

Published
2022
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239. Clinical characteristics of 10 children with a pediatric inflammatory multisystem syndrome associated with COVID-19 in Iran.

Author

Shahbaznejad, Leila, Navaeifar, Mohammad Reza, Abbaskhanian, Ali, Hosseinzadeh, Fatemeh, Rahimzadeh, Golnar, and Rezai, Mohammad Sadegh

Subjects
COVID-19, TOXIC shock syndrome, SYMPTOMS, MUCOCUTANEOUS lymph node syndrome, SYNDROMES, BLOOD sedimentation
Abstract

Background: Although symptoms and signs of COVID-19 (Coronavirus disease 2019) in children are milder than adults, there are reports of more severe cases which were defined as pediatric inflammatory multisystem syndrome (PIMS). The purpose of this report was to describe the possible association between COVID-19 and PIMS in children.Methods: From 28 March to 24 June 2020, 10 febrile children were admitted with COVID-19 infection showing characteristics of PIMS in Buali tertiary hospital of Sari, in Mazandaran province, northern Iran. Demographic and clinical characteristics, laboratory and imaging findings, and therapeutic modalities were recorded and analyzed.Results: The mean age of the patients was 5.37 ± 3.9 years (13 months to 12 years). Six of them were boys. Kawasaki disease, myocarditis, toxic shock syndrome, appendicitis, sepsis, urosepsis, prolonged febrile seizure, acute hemorrhagic edema of infancy, and COVID-19-related pneumonia were their first presentation. All of them had increased C-reactive protein levels, and most of them had elevated erythrocyte sedimentation rate, lymphopenia, anemia, and hypoalbuminemia. Three of them had thrombocytopenia(PLT < 106). Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure and another case was discharged with a giant coronary aneurysm.Conclusions: Children with COVID-19 may present symptoms similar to Kawasaki disease and inflammatory syndromes. PIMS should be considered in children with fever, rash, seizure, cough, tachypnea, and gastrointestinal symptoms such as vomiting, diarrhea, and abdominal pain. [ABSTRACT FROM AUTHOR]

Published
2020
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240. Potential of lytic bacteriophages as disinfectant to control of Pseudomonas aeruginosa on fomites.

Author

Rahimzadeh, Golnar, Zazouli, Mohammad Ali, and Rezai, Mohammad Sadegh

Subjects
*BACTERIOPHAGES, *PSEUDOMONAS aeruginosa, *NOSOCOMIAL infections, *BACTERIAL cells, *SANITATION, *BIOCIDES, *DISINFECTION & disinfectants, *PATHOGENIC microorganisms
Abstract

Purpose: Nosocomial infections can be transmitted by contaminated hospital surfaces with resistant pathogens. Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that causes public healthcare issues. Conventional sanitation is not efficiently contributing to removing resistant pathogens. Bacteriophages suggest safe and specific decontamination. Bacteriophages are a promising alternative strategy to chemical biocides. This research aimed to evaluate the potential of phage in controlling P. aeruginosa in infected hard surfaces. Methods: Bacteriophage was isolated from hospital wastewater. The efficiency lytic activity of phage against P. aeruginosa was assessed on various infected hard surfaces as plastic and ceramic. 50 µl of the phage lysate (2 × 1012 PFU/mL) and 50 µl of 70% Ethanol solution separately were spread on the different infected surfaces. After 15 min, 1, 3, 6, and 24 h, surfaces were directly sampled by contact plates. The bacterial load was evaluated by enumerating plate CFU. Results: Cystoviridae phages with titer (2 × 1012 PFU/mL) efficiently can reduce P. aeruginosa on contaminated surfaces. The treated surfaces with 70% Ethanol solution and phage showed an evident drop in bacterial cell number. Conclusions: Bacteriophages can be used as a new option for the development of biological products aimed at the control and deletion of pathogens on contaminated hard surfaces. [ABSTRACT FROM AUTHOR]

Published
2022
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241. Evaluation of bacteriophage products against burn wound Methicillin-resistant Staphylococcus aureus (MRSA) infections.

Author

Rahimzadeh, Golnar, Gill, Pooria, Saeedi, Majid, Ghasemi, Maryam, Rokni, Ghasem Rahmatpour, Rostamkalaei, Seyyed Sohrab, Nadi Ghara, Ali Asghar, and Rezai, Mohammad Sadegh

Subjects
METHICILLIN-resistant staphylococcus aureus, BACTERIOPHAGES, GRANULATION tissue, WOUND healing, WOUND infections
Abstract

The major problem in the management of burn wounds are infections. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major cause of infection in burn wounds. Antibiotic resistant bacteria around the world has become a major therapeutic challenge. Bacteriophages and their lysine are suggested as an antimicrobial alternative agent. Phage display technique is suggested for production of recombinant lysine by Nano carrier technology. The approach of this study was to evaluate the potential of recombinant Nano phage efficacy in MRSA burn wound infection in vivo. The 3rd degree burn wounds were induced in 54 rats and infected with MRSA ATCC 33591 via the topical route in four groups. Burn wound size was measured in 0, 14, 21, 28 days. The efficacy of Nano phage gel was assessed on the basis of percentage collagen deposition, granulation tissue, neovascularization, fibroblastic maturity, re-epithelization, and scar formation in rats following treatment in 14, 21, 28 days. The results showed that the percentage of wound size were 3 cm on base line day and the average macroscopic wound healing rates were increased in the prevention groups receiving the recombinant Nano phage gel and natural phage gel, in the treatment groups with secondary infection receiving the recombinant Nano phage gel and the natural phage gel, and in the two control groups respectively. The average microscopic wound healing rates were increased in the prevention groups receiving the recombinant Nano phage gel and natural phage gel, in the treatment groups with secondary infection receiving the recombinant Nano phage gel and the natural phage gel, and in the two control groups respectively. In conclusion the recombinant Nano phage gel is efficacy to treat and prevent MRSA burn wound infection. [ABSTRACT FROM AUTHOR]

Published
2020
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242. Alcohol use and burden for 195 countries and territories, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016

Author

Uthman, Olalekan A, Valdez, Pascual R, Van Boven, Job F M, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Wagnew, Fasil Wagnew Shiferaw, Waheed, Yasir, Wang, Yuan-Pang, Weiderpass, Elisabete, Weldegebreal, Fitsum, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Widecka, Justyna, Wijeratne, Tissa, Wyper, Grant M A, Xu, Gelin, Yamada, Tomohide, Yano, Yuichiro, Ye, Pengpeng, Yimer, Ebrahim M, Yip, Paul, Yirsaw, Biruck Desalegn, Yisma, Engida, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zachariah, Geevar, Zaidi, Zoubida, Zamani, Mohammad, Zhang, Xueying, Zodpey, Sanjay, Mokdad, Ali H, Naghavi, Mohsen, Griswold, Max G, Fullman, Nancy, Hawley, Caitlin, Arian, Nicholas, Zimsen, Stephanie R M, Tymeson, Hayley D, Venkateswaran, Vidhya, Tapp, Austin Douglas, Forouzanfar, Mohammad H, Salama, Joseph S, Abate, Kalkidan Hassen, Abate, Degu, Abay, Solomon M, Abbafati, Cristiana, Abdulkader, Rizwan Suliankatchi, Abebe, Zegeye, Aboyans, Victor, Abrar, Mohammed Mehdi, Acharya, Pawan, Adetokunboh, Olatunji O, Adhikari, Tara Ballav, Adsuar, Jose C, Afarideh, Mohsen, Agardh, Emilie Elisabet, Agarwal, Gina, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Ahmed, Muktar Beshir, Akibu, Mohammed, Akinyemiju, Tomi, Akseer, Nadia, Asfoor, Deena H Al, Al-Aly, Ziyad, Alahdab, Fares, Alam, Khurshid, Albujeer, Ammar, Alene, Kefyalew Addis, Ali, Raghib, Ali, Syed Danish, Alijanzadeh, Mehran, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Allebeck, Peter, Alvis-Guzman, Nelson, Amare, Azmeraw T, Aminde, Leopold N, Ammar, Walid, Amoako, Yaw Ampem, Amul, Gianna Gayle Herrera, Andrei, Catalina Liliana, Angus, Colin, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Aremu, Olatunde, Ärnlöv, Johan, Artaman, Al, Aryal, Krishna K, Assadi, Reza, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide F, Awasthi, Ashish, Ayele, Henok Tadesse, Ayer, Rakesh, Ayuk, Tambe B, Azzopardi, Peter S, Badali, Hamid, Badawi, Alaa, Banach, Maciej, Barker-Collo, Suzanne Lyn, Barrero, Lope H, Basaleem, Huda, Baye, Estifanos, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Béjot, Yannick, Belachew, Abate Bekele, Belay, Saba Abraham, Bennett, Derrick A, Bensenor, Isabela M, Bernabe, Eduardo, Bernstein, Robert S, Beyene, Addisu Shunu, Beyranvand, Tina, Bhaumik, Soumyadeeep, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bililign, Nigus, Birlik, Sait Mentes, Birungi, Charles, Bizuneh, Hailemichael, Bjerregaard, Peter, Bjørge, Tone, Borges, Guilherme, Bosetti, Cristina, Boufous, Soufiane, Bragazzi, Nicola Luigi, Brenner, Hermann, Butt, Zahid A, Cahuana-Hurtado, Lucero, Calabria, Bianca, Campos-Nonato, Ismael R, Campuzano, Julio Cesar, Carreras, Giulia, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castillo Rivas, Jacqueline, Catalá-López, Ferrán, Chang, Jung-Chen, Charlson, Fiona J, Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chowdhury, Rajiv, Christopher, Devasahayam J, Chung, Sheng-Chia, Ciobanu, Liliana G, Claro, Rafael M, Conti, Sara, Cousin, Ewerton, Criqui, Michael H, Dachew, Berihun Assefa, Dargan, Paul I, Daryani, Ahmad, Das Neves, José, Davletov, Kairat, De Castro, Filipa, De Courten, Barbora, De Neve, Jan-Walter, Degenhardt, Louisa, Demoz, Gebre Teklemariam, Des Jarlais, Don C, Dey, Subhojit, Dhaliwal, Rupinder Singh, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Doku, David Teye, Doyle, Kerrie E, Dubey, Manisha, Dubljanin, Eleonora, Duncan, Bruce B, Ebrahimi, Hedyeh, Edessa, Dumessa, El Sayed Zaki, Maysaa, Ermakov, Sergei Petrovich, Erskine, Holly E, Esteghamati, Alireza, Faramarzi, Mahbobeh, Farioli, Andrea, Faro, Andre, Farvid, Maryam S, Farzadfar, Farshad, Feigin, Valery L, Felisbino-Mendes, Mariana Santos, Fernandes, Eduarda, Ferrari, Alize J, Ferri, Cleusa P, Fijabi, Daniel Obadare, Filip, Irina, Finger, Jonas David, Fischer, Florian, Flaxman, Abraham D, Franklin, Richard Charles, Futran, Neal D, Gallus, Silvano, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M, Ghadimi, Reza, Ghandour, Lilian A, Ghimire, Mamata, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Giref, Ababi Zergaw Z, Gona, Philimon N, Gopalani, Sameer Vali, Gotay, Carolyn C, Goulart, Alessandra C, Greaves, Felix, Grosso, Giuseppe, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gutiérrez, Reyna Alma, GVS, Murthy, Hafezi-Nejad, Nima, Hagos, Tekleberhan Beyene, Hailu, Gessessew Bugssa, Hamadeh, Randah R, Hankey, Graeme J, Harb, Hilda L, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Simon I, Heibati, Behzad, Henok, Andualem, Heredia-Pi, Ileana, Hernández-Llanes, Norberto Francisco, Herteliu, Claudiu, Hibstu, Desalegn Ts Tsegaw, Hoogar, Praveen, Horita, Nobuyuki, Hosgood, H Dean, Hosseini, Mostafa, Hostiuc, Mihaela, Hu, Guoqing, Huang, Hsiang, Husseini, Abdullatif, Idrisov, Bulat, Ileanu, Bogdan Vasile, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jackson, Maria D, Jakovljevic, Mihajlo, Jalu, Moti Tolera, Jayatilleke, Achala Upendra, Jha, Ravi Prakash, Jonas, Jost B, Jozwiak, Jacek Jerzy, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kapil, Umesh, Kasaeian, Amir, Kassa, Tesfaye D Dessale, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Kebede, Seifu, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Kengne, Andre Pascal, Khader, Yousef, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A, Khan, Md Nuruzzaman, Khang, Young-Ho, Khater, Mona M, Khubchandani, Jagdish, Kim, Cho-Il, Kim, Daniel, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kivimäki, Mika, Kochhar, Sonali, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Krishan, Kewal, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kulkarni, Veena S, Kumar, Pushpendra, Lafranconi, Alessandra, Lakshmana Balaji, Arjun, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lami, Faris Hasan, Lan, Qing, Lang, Justin J, Lansky, Sonia, Larsson, Anders O, Latifi, Arman, Leasher, Janet L, Lee, Paul H, Leigh, James, Leinsalu, Mall, Leung, Janni, Levi, Miriam, Li, Yichong, Lim, Lee-Ling, Lobato-Cordero, Andrea, Lopez, Alan D, Lotufo, Paulo A, Macarayan, Erlyn Rachelle King, Machado, Isis Eloah, Madotto, Fabiana, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Mapoma, Chabila Christopher, Martinez-Raga, Jose, Maulik, Pallab K, Mazidi, Mohsen, Mckee, Martin, Mehta, Varshil, Meier, Toni, Mekonen, Tesfa, Meles, Kidanu Gebremariam, Melese, Addisu, Memiah, Peter T N, Mendoza, Walter, Mengistu, Desalegn Tadese, Mensah, George A, Meretoja, Tuomo J, Mezgebe, Haftay Berhane, Miazgowski, Tomasz, Miller, Ted R, Mini, Gk, Mirica, Andreea, Mirrakhimov, Erkin M, Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadifard, Noushin, Mohammed, Shafiu, Monasta, Lorenzo, Moraga, Paula, Morawska, Lidia, Mousavi, Seyyed Meysam, Mukhopadhyay, Satinath, Musa, Kamarul Imran, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Nayak, Mudavath Siva Durga Prasad, Nejjari, Chakib, Neupane, Subas, Neupane, Sudan Prasad, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nguyen, Long Hoang, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Noubiap, Jean Jacques, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olagunju, Andrew T, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oommen, Anu Mary, Oren, Eyal, Orpana, Heather M, Ortega-Altamirano, Doris D V, Ortiz, Justin R, Ota, Erika, Owolabi, Mayowa Ojo, Oyekale, Abayomi Samuel, P A, Mahesh, Pana, Adrian, Park, Eun-Kee, Parry, Charles D H, Parsian, Hadi, Patle, Ajay, Patton, George C, Paudel, Deepak, Petzold, Max, Phillips, Michael R, Pillay, Julian David, Postma, Maarten J, Pourmalek, Farshad, Prabhakaran, Dorairaj, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Afarin, Rahman, Mahfuzar, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Sree Bhushan, Ram, Usha, Rana, Saleem M, Ranabhat, Chhabi Lal, Rawaf, David Laith, Rawaf, Salman, Reiner, Robert C, Reis, Cesar, Renzaho, Andre M N, Rezai, Mohammad Sadegh, Roever, Leonardo, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Rostami, Ali, Roth, Gregory A, Roy, Ambuj, Sabde, Yogesh Damodar, Saddik, Basema, Safiri, Saeid, Sahebkar, Amirhossein, Saleem, Zikria, Salomon, Joshua A, Salvi, Sundeep Santosh, Sanabria, Juan, Sanchez-Niño, Maria Dolores, Santomauro, Damian Francesco, Santos, Itamar S, Santric Milicevic, Milena M M, Sarker, Abdur Razzaque, Sarmiento-Suárez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Satpathy, Maheswar, Sawhney, Monika, Saxena, Sonia, Saylan, Mete, Schaub, Michael P, Schmidt, Maria Inês, Schneider, Ione J C, Schöttker, Ben, Schutte, Aletta Elisabeth, Schwendicke, 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N, Zimsen, S, Tymeson, H, Venkateswaran, V, Tapp, A, Forouzanfar, M, Salama, J, Abate, K, Abate, D, Abay, S, Abbafati, C, Abdulkader, R, Abebe, Z, Aboyans, V, Abrar, M, Acharya, P, Adetokunboh, O, Adhikari, T, Adsuar, J, Afarideh, M, Agardh, E, Agarwal, G, Aghayan, S, Agrawal, S, Ahmed, M, Akibu, M, Akinyemiju, T, Akseer, N, Asfoor, D, Al-Aly, Z, Alahdab, F, Alam, K, Albujeer, A, Alene, K, Ali, R, Ali, S, Alijanzadeh, M, Aljunid, S, Alkerwi, A, Allebeck, P, Alvis-Guzman, N, Amare, A, Aminde, L, Ammar, W, Amoako, Y, Amul, G, Andrei, C, Angus, C, Ansha, M, Antonio, C, Aremu, O, Ärnlöv, J, Artaman, A, Aryal, K, Assadi, R, Ausloos, M, Avila-Burgos, L, Avokpaho, E, Awasthi, A, Ayele, H, Ayer, R, Ayuk, T, Azzopardi, P, Badali, H, Badawi, A, Banach, M, Barker-Collo, S, Barrero, L, Basaleem, H, Baye, E, Bazargan-Hejazi, S, Bedi, N, Béjot, Y, Belachew, A, Belay, S, Bennett, D, Bensenor, I, Bernabe, E, Bernstein, R, Beyene, A, Beyranvand, T, Bhaumik, S, Bhutta, Z, Biadgo, B, Bijani, A, Bililign, 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Meles, Kidanu Gebremariam, Melese, Addisu, Memiah, Peter T N, Mendoza, Walter, Mengistu, Desalegn Tadese, Mensah, George A, Meretoja, Tuomo J, Mezgebe, Haftay Berhane, Miazgowski, Tomasz, Miller, Ted R, Mini, Gk, Mirica, Andreea, Mirrakhimov, Erkin M, Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadifard, Noushin, Mohammed, Shafiu, Monasta, Lorenzo, Moraga, Paula, Morawska, Lidia, Mousavi, Seyyed Meysam, Mukhopadhyay, Satinath, Musa, Kamarul Imran, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Nayak, Mudavath Siva Durga Prasad, Nejjari, Chakib, Neupane, Suba, Neupane, Sudan Prasad, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nguyen, Long Hoang, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Noubiap, Jean Jacque, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olagunju, Andrew T, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oommen, Anu Mary, Oren, Eyal, 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Zhang, Xueying, Zodpey, Sanjay, Mokdad, Ali H, Naghavi, Mohsen, Murray, Christopher J L, and Gakidou, Emmanuela

Subjects
Adult, Male, Adolescent, Alcohol Drinking, Global Health, Risk Assessment, Global Burden of Disease, Young Adult, Age Distribution, Retrospective Studie, General & Internal Medicine, Cause of Death, Quality-Adjusted Life Year, Prevalence, Medicine (all) Alcohol GBD, Sex Distribution, Aged, Aged, 80 and over, Risk Factor, Medicine (all), Commerce, Middle Aged, Observational Studies as Topic, Prospective Studie, Population Surveillance, Female, Human medicine, Human
Abstract

Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2·2% (95% uncertainty interval [UI] 1·5–3·0) of age-standardised female deaths and 6·8% (5·8–8·0) of age-standardised male deaths. Among the population aged 15–49 years, alcohol use was the leading risk factor globally in 2016, with 3·8% (95% UI 3·2–4·3) of female deaths and 12·2% (10·8–13·6) of male deaths attributable to alcohol use. For the population aged 15–49 years, female attributable DALYs were 2·3% (95% UI 2·0–2·6) and male attributable DALYs were 8·9% (7·8–9·9). The three leading causes of attributable deaths in this age group were tuberculosis (1·4% [95% UI 1·0–1·7] of total deaths), road injuries (1·2% [0·7–1·9]), and self-harm (1·1% [0·6–1·5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27·1% (95% UI 21·2–33·3) of total alcohol-attributable female deaths and 18·9% (15·3–22·6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0–0·8) standard drinks per week. Interpretation: Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption. Funding: Bill & Melinda Gates Foundation.

243. Phage Therapy for Prevention and Treatment of Infections in Children.

Author

Rahimzadeh, Golnar and Sadegh Rezai, Mohammad

Subjects
*RESPIRATORY infections, *URINARY tract infections, *INFECTION prevention, *JUVENILE diseases, *BACTERIOPHAGES
Abstract

In spite of the primary and secondary preventions from infections, the load of infectiousdiseases still accounts for a major part of children diseases. Irrational use of antibiotics has led tothe emergence and spread of antibiotic-resistant bacteria all over the world. With the developmentof antibiotic-resistant bacteria, despite the development in the production of new antimicrobialcompounds, the imminent return of a pre-antibiotic period is happening. Phage therapy isproposed as a preventive and therapeutic option for some infections in children. This study aimedat integrating and combining the results of phage therapy studies in children using the reviewmethod.This study was carried out based on the authenticated electronic databases of Web of Science,Google Scholar, Pubmed, and Scopus in 1990-2018.Eighteen articles out of 8140 articles in Google Scholar, 1 article out of 4 articles in Scopus, 1article out of 4 articles in Web Science, and 1 article out of 5 articles in Pubmed were included inthe study through selecting phage studies on prevention of infections in children in 1990-2018.Results proved that 5 studies on children used polyvalent phage to prevent diarrhea, shigellosis,and gastrointestinal infections and 1 study employed phage spray to prevent gastrointestinalinfection in children. Phage therapy results indicated that 7 studies used the oral use of phages fordiarrhea and salmonellosis, 3 studies used the subcutaneous and topical use of phages forosteomyelitis, skin diseases, and abscess, 1 study used phage intramuscular injection for urinarytract infection, 1 study used intramuscular injection for the infection of upper respiratory tract, 1study used it for meningitis, and 3 studies used it for septicemia treatment.Conclusion: The use of oral cocktail bacteriophages prevents from the gastrointestinal infectionscaused by Enterobacteriaceae bacteria. Phages are effective for oral treatment for gastrointestinalinfections, local infections for skin infections, injections for sepsis, urinary tract infections, andrespiratory tract infections. [ABSTRACT FROM AUTHOR]

Published
2018

244. Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1

Author

Galles, Natalie C, Liu, Patrick Y, Updike, Rachel L, Fullman, Nancy, Nguyen, Jason, Rolfe, Sam, Sbarra, Alyssa N, Schipp, Megan F, Marks, Ashley, Abady, Gdiom Gebreheat, Abbas, Kaja M, Abbasi, Sumra Wajid, Abbastabar, Hedayat, Abd-Allah, Foad, Abdoli, Amir, Abolhassani, Hassan, Abosetugn, Akine Eshete, Adabi, Maryam, Adamu, Abdu A, Adetokunboh, Olatunji O, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afzal, Saira, Aghamir, Seyed Mohammad Kazem, Ahinkorah, Bright Opoku, Ahmad, Sohail, Ahmad, Tauseef, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Akalu, Yonas, Aklilu, Addis, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Albano, Luciana, Alemayehu, Yosef, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Alhassan, Robert Kaba, Ali, Liaqat, Aljunid, Syed Mohamed, Almustanyir, Sami, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amu, Hubert, Andrei, Catalina Liliana, Andrei, Tudorel, Ansar, Adnan, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antony, Benny, Arabloo, Jalal, Arab-Zozani, Morteza, Artanti, Kurnia Dwi, Arulappan, Judie, Awan, Asma Tahir, Awoke, Mamaru Ayenew, Ayza, Muluken Altaye, Azarian, Ghasem, Azzam, Ahmed Y, B, Darshan B, Babar, Zaheer-Ud-Din, Balakrishnan, Senthilkumar, Banach, Maciej, Bante, Simachew Animen, Bärnighausen, Till Winfried, Barqawi, Hiba Jawdat, Barrow, Amadou, Bassat, Quique, Bayarmagnai, Narantuya, Bejarano Ramirez, Diana Fernanda, Bekuma, Tariku Tesfaye, Belay, Habtamu Gebrehana, Belgaumi, Uzma Iqbal, Bhagavathula, Akshaya Srikanth, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattacharyya, Krittika, Bibi, Sadia, Bijani, Ali, Biondi, Antonio, Boloor, Archith, Braithwaite, Dejana, Buonsenso, Danilo, Butt, Zahid A, Camargos, Paulo, Carreras, Giulia, Carvalho, Felix, Castañeda-Orjuela, Carlos A, Chakinala, Raja Chandra, Charan, Jaykaran, Chatterjee, Souranshu, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Chowdhury, Fazle Rabbi, Christopher, Devasahayam J, Chu, Dinh-Toi, Chung, Sheng-Chia, Cortesi, Paolo Angelo, Costa, Vera Marisa, Couto, Rosa A S, Dadras, Omid, Dagnew, Amare Belachew, Dagnew, Baye, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, De Neve, Jan-Walter, Derbew Molla, Meseret, Derseh, Behailu Tariku, Desai, Rupak, Desta, Abebaw Alemayehu, Dhamnetiya, Deepak, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dianatinasab, Mostafa, Diaz, Daniel, Djalalinia, Shirin, Dorostkar, Fariba, Edem, Bassey, Edinur, Hisham Atan, Eftekharzadeh, Sahar, El Sayed, Iman, El Sayed Zaki, Maysaa, Elhadi, Muhammed, El-Jaafary, Shaimaa I, Elsharkawy, Aisha, Enany, Shymaa, Erkhembayar, Ryenchindorj, Esezobor, Christopher Imokhuede, Eskandarieh, Sharareh, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Fares, Jawad, Faris, Pawan Sirwan, Feleke, Berhanu Elfu, Ferede, Tomas Y, Fernandes, Eduarda, Fernandes, João C, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Francis, Mark Rohit, Fukumoto, Takeshi, Gad, Mohamed M, Gaidhane, Shilpa, Gallus, Silvano, Garg, Tushar, Geberemariyam, Biniyam Sahiledengle, Gebre, Teshome, Gebregiorgis, Birhan Gebresillassie, Gebremedhin, Ketema Bizuwork, Gebremichael, Berhe, Gessner, Bradford D, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghashghaee, Ahmad, Gilani, Syed Amir, Glăvan, Ionela-Roxana, Glushkova, Ekaterina Vladimirovna, Golechha, Mahaveer, Gonfa, Kebebe Bekele, Gopalani, Sameer Vali, Goudarzi, Houman, Gubari, Mohammed Ibrahim Mohialdeen, Guo, Yuming, Gupta, Veer Bala, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Haeuser, Emily, Halwani, Rabih, Hamidi, Samer, Hanif, Asif, Haque, Shafiul, Harapan, Harapan, Hargono, Arief, Hashi, Abdiwahab, Hassan, Shoaib, Hassanein, Mohamed H, Hassanipour, Soheil, Hassankhani, Hadi, Hay, Simon I, Hayat, Khezar, Hegazy, Mohamed I, Heidari, Golnaz, Hezam, Kamal, Holla, Ramesh, Hoque, Mohammad Enamul, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Househ, Mowafa, Hsieh, Vivian Chia-rong, Huang, Junjie, Humayun, Ayesha, Hussain, Rabia, Hussein, Nawfal R, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inamdar, Sumant, Iqbal, Usman, Irham, Lalu Muhammad, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, Itumalla, Ramaiah, Jha, Ravi Prakash, Joukar, Farahnaz, Kabir, Ali, Kabir, Zubair, Kalhor, Rohollah, Kamal, Zul, Kamande, Stanley M, Kandel, Himal, Karch, André, Kassahun, Getinet, Kassebaum, Nicholas J, Katoto, Patrick DMC, Kelkay, Bayew, Kengne, Andre Pascal, Khader, Yousef Saleh, Khajuria, Himanshu, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Junaid, Khan, Maseer, Khan, Moien AB, Khang, Young-Ho, Khoja, Abdullah T, Khubchandani, Jagdish, Kim, Gyu Ri, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kuate Defo, Barthelemy, Kulkarni, Vaman, Kumar, Avinash, Kumar, G Anil, Kumar, Nithin, Kwarteng, Alexander, La Vecchia, Carlo, Lami, Faris Hasan, Landires, Iván, Lasrado, Savita, Lassi, Zohra S, Lee, Hankil, Lee, Yeong Yeh, Levi, Miriam, Lewycka, Sonia, Li, Shanshan, Liu, Xuefeng, Lobo, Stany W, Lopukhov, Platon D, Lozano, Rafael, Lutzky Saute, Ricardo, Magdy Abd El Razek, Muhammed, Makki, Alaa, Malik, Ahmad Azam, Mansour-Ghanaei, Fariborz, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martins-Melo, Francisco Rogerlândio, Matthews, Philippa C, Medina, John Robert Carabeo, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Meretoja, Tuomo J, Mersha, Amanual Getnet, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Miazgowski, Bartosz, Milne, George J, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei, Hamid Reza, Misra, Sanjeev, Mithra, Prasanna, Moghadaszadeh, Masoud, Mohamed, Teroj Abdulrahman, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammed, Arif, Mohammed, Shafiu, Mohapatra, Archisman, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moni, Mohammad Ali, Montasir, Ahmed Al, Moore, Catrin E, Moradi, Ghobad, Moradzadeh, Rahmatollah, Moraga, Paula, Mueller, Ulrich Otto, Munro, Sandra B, Naghavi, Mohsen, Naimzada, Mukhammad David, Naveed, Muhammad, Nayak, Biswa Prakash, Negoi, Ionut, Neupane Kandel, Sandhya, Nguyen, Trang Huyen, Nikbakhsh, Rajan, Ningrum, Dina Nur Anggraini, Nixon, Molly R, Nnaji, Chukwudi A, Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nwatah, Vincent Ebuka, Oancea, Bogdan, Ochir, Chimedsuren, Ogbo, Felix Akpojene, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Onwujekwe, Obinna E, Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Pakshir, Keyvan, Park, Eun-Cheol, Pashazadeh Kan, Fatemeh, Pathak, Mona, Paudel, Rajan, Pawar, Shrikant, Pereira, Jeevan, Peres, Mario F P, Perianayagam, Arokiasamy, Pinheiro, Marina, Pirestani, Majid, Podder, Vivek, Polibin, Roman V, Pollok, Richard Charles G, Postma, Maarten J, Pottoo, Faheem Hyder, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahimi-Movaghar, Vafa, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmawaty, Setyaningrum, Rajesh, Aashish, Ramshaw, Rebecca E, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Sowmya J, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre M N, Rezaei, Negar, Rezai, Mohammad Sadegh, Rios-Blancas, Maria, Rogowski, Emma L B, Ronfani, Luca, Rwegerera, Godfrey M, Saad, Anas M, Sabour, Siamak, Saddik, Basema, Saeb, Mohammad Reza, Saeed, Umar, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salam, Nasir, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M, Sanabria, Juan, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sawhney, Monika, Saxena, Deepak, Saxena, Sonia, Seidu, Abdul-Aziz, Seylani, Allen, Shaikh, Masood Ali, Shamsizadeh, Morteza, Shetty, Pavanchand H, Shigematsu, Mika, Shin, Jae Il, Sidemo, Negussie Boti, Singh, Ambrish, Singh, Jasvinder A, Sinha, Smriti, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soheili, Amin, Tadesse, Eyayou Girma, Tamiru, Animut Tagele, Tan, Ker-Kan, Tekalegn, Yohannes, Temsah, Mohamad-Hani, Thakur, Bhaskar, Thapar, Rekha, Thavamani, Aravind, Tobe-Gai, Ruoyan, Tohidinik, Hamid Reza, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tripathi, Manjari, Tsegaye, Berhan, Tsegaye, Gebiyaw Wudie, Ullah, Anayat, Ullah, Saif, Ullah, Sana, Unim, Brigid, Vacante, Marco, Velazquez, Diana Zuleika, Vo, Bay, Vollmer, Sebastian, Vu, Giang Thu, Vu, Linh Gia, Waheed, Yasir, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Yiğit, Vahit, Yirdaw, Birhanu Wubale, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Yuce, Deniz, Yunusa, Ismaeel, Zamani, Mohammad, Zamanian, Maryam, Zewdie, Dejene Tesfaye, Zhang, Zhi-Jiang, Zhong, Chenwen, Zumla, Alimuddin, Murray, Christopher J L, Lim, Stephen S, and Mosser, Jonathan F

Abstract

Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time.

Published
2021
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245. COVID-19-Associated Multisystem Inflammatory Syndrome Complicated with Giant Coronary Artery Aneurysm

Author

Reza Navaeifar, Mohammad, Shahbaznejad, Leila, Sadeghi Lotfabadi, Ali, and Sadegh Rezai, Mohammad

Abstract

In the early stages of the outbreak of the novel coronavirus disease 2019 (COVID-19), it was assumed that this infection is very mild and uncommon in children. However, recent reports have shown that children may also develop the disease and its severe complications. These complications included shock, multisystem inflammatory syndrome in children (MIS-C), and pneumonia in children. A previously healthy 14-month-old boy presented with fever, irritability, and skin rash, besides changes in the lips, conjunctiva, and tongue. His medical history, clinical presentations, treatment, laboratory data, and follow-up information were recorded. He was treated according to the diagnosis of Kawasaki disease (KD). He had a history of close contact with a COVID-19 patient. However, the result of reverse transcription-polymerase chain reaction (RT-PCR) assay for COVID-19 was negative. Immunoglobulin M for COVID-19 was positive (1.20), while immunoglobulin G was negative (0.37). Three weeks later, seroconversion of COVID-19 immunoglobulin G (1.42) occurred. Despite treatment with two doses of intravenous immunoglobulin and methylprednisolone, coronary artery ectasia was detected. On the sixth day of hospitalization, the patient experienced hypotension, which necessitated treatment with inotropic drugs and resulted in a change of diagnosis to MIS-C. The later echocardiography showed evidence of coronary artery aneurysm (CAA), which finally changed to giant CAA. Although the patient was treated with infliximab, the size of CAA showed a significant decrease in the one-month follow-up. This is the first report of MIS-C during the COVID-19 pandemic in Iran, accompanied by KD, which was complicated with giant CAA.

Published
2021
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246. Evaluation of bacteriophage products against burn wound Methicillin-resistant Staphylococcus aureus(MRSA) infections

Author

Rahimzadeh, Golnar, Gill, Pooria, Saeedi, Majid, Ghasemi, Maryam, Rokni, Ghasem Rahmatpour, Rostamkalaei, Seyyed Sohrab, Nadi Ghara, Ali Asghar, and Rezai, Mohammad Sadegh

Abstract

The major problem in the management of burn wounds are infections. Methicillin-resistant Staphylococcus aureus(MRSA) is one of the major cause of infection in burn wounds. Antibiotic resistant bacteria around the world has become a major therapeutic challenge. Bacteriophages and their lysine are suggested as an antimicrobial alternative agent. Phage display technique is suggested for production of recombinant lysine by Nano carrier technology. The approach of this study was to evaluate the potential of recombinant Nano phage efficacy in MRSA burn wound infection in vivo.

Published
2020
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247. Additional file 1: of Factors associated with door-in to door-out delays among ST-segment elevation myocardial infarction (STEMI) patients transferred for primary percutaneous coronary intervention: a population-based cohort study in Ontario, Canada

Author

Oumin Shi, Anam Khan, Rezai, Mohammad, Jackevicius, Cynthia, Jafna Cox, Atzema, Clare, Ko, Dennis, ThÊrèSe Stukel, Lambert, Laurie, Natarajan, Madhu, Zheng, Zhi-Jie, and Tu, Jack

Subjects
3. Good health
Abstract

Data supplement containing additional tables and figures (e.g., disease classification codes, benchmark times etc.). (DOCX 130 kb)

248. Additional file 1: of Factors associated with door-in to door-out delays among ST-segment elevation myocardial infarction (STEMI) patients transferred for primary percutaneous coronary intervention: a population-based cohort study in Ontario, Canada

Author

Oumin Shi, Anam Khan, Rezai, Mohammad, Jackevicius, Cynthia, Jafna Cox, Atzema, Clare, Ko, Dennis, ThÊrèSe Stukel, Lambert, Laurie, Natarajan, Madhu, Zheng, Zhi-Jie, and Tu, Jack

Subjects
3. Good health
Abstract

Data supplement containing additional tables and figures (e.g., disease classification codes, benchmark times etc.). (DOCX 130 kb)

249. Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017

Author

Murray, Christopher J L, Callender, Charlton S K H, Kulikoff, Xie Rachel, Srinivasan, Vinay, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M, Abbasi, Nooshin, Abbastabar, Hedayat, Abdela, Jemal, Abdelalim, Ahmed, Abdel-Rahman, Omar, Abdi, Alireza, Abdoli, Nasrin, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abebo, Teshome Abuka, Abejie, Ayenew Negesse, Aboyans, Victor, Abraha, Haftom Niguse, Abreu, Daisy Maria Xavier, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen M E, Accrombessi, Manfred Mario Kokou, Acharya, Pawan, Adamu, Abdu A, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Adhikari, Tara Ballav, Adib, Mina G, Adou, Arsène Kouablan, Adsuar, Jose C, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agesa, Kareha M, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmed, Muktar Beshir, Ahmed, Sayem, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akanda, Ali S, Akbari, Mohammad Esmaeil, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akseer, Nadia, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alebel, Animut, Aleman, Alicia V, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Raghib, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Almasi, Ali, Alonso, Jordi, Al-Raddadi, Rajaa M, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ammar, Walid, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Appiah, Seth Christopher Yaw, Aremu, Olatunde, Areri, Habtamu Abera, Arian, Nicholas, Ärnlöv, Johan, Artaman, Al, Aryal, Krishna K, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Asgedom, Solomon Weldegebreal, Assadi, Reza, Atey, Tesfay Mehari Mehari, Atique, Suleman, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avokpaho, Euripide F G A, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayele, Yohanes, Ayer, Rakesh, Ayuk, Tambe B, Azzopardi, Peter S, Babalola, Tesleem Kayode, Babazadeh, Arefeh, Badali, Hamid, Badawi, Alaa, Bali, Ayele Geleto, Banach, Maciej, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Basaleem, Huda, Bassat, Quique, Basu, Arindam, Baune, Bernhard T, Baynes, Habtamu Wondifraw, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Belay, Aregawi Gebreyesus, Belay, Ezra, Belay, Saba Abraham, Belay, Yihalem Abebe, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Bergeron, Gilles, Berhane, Adugnaw, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bertolacci, Gregory J, Beuran, Mircea, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Birlik, Sait Mentes, Birungi, Charles, Biswas, Tuhin, Bizuneh, Hailemichael, Bleyer, Archie, Basara, Berrak Bora, Bosetti, Cristina, Boufous, Soufiane, Brady, Oliver J, Bragazzi, Nicola Luigi, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Brewer, Jerry D, Briant, Paul Svitil, Britton, Gabrielle, Burstein, Roy, Busse, Reinhard, Butt, Zahid A, Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cano, Jorge, Car, Mate, Cárdenas, Rosario, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castillo Rivas, Jacqueline, Castro, Franz, Catalá-López, Ferrán, Çavlin, Alanur, Cerin, Ester, Chalek, Julian, Chang, Hsing-Yi, Chang, Jung-Chen, Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chiang, Peggy Pei-Chia, Chin, Ken Lee, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal, Choi, Jee-Young J, Chowdhury, Rajiv, Christopher, Devasahayam J, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Claro, Rafael M, Collado-Mateo, Daniel, Constantin, Maria-Magdalena, Conti, Sara, Cooper, Cyrus, Cooper, Leslie Trumbull, Cornaby, Leslie, Cortesi, Paolo Angelo, Cortinovis, Monica, Costa, Megan, Cromwell, Elizabeth, Crowe, Christopher Stephen, Cukelj, Petra, Cunningham, Matthew, Daba, Alemneh Kabeta, Dachew, Berihun Assefa, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Daryani, Ahmad, Das Gupta, Rajat, Das Neves, José, Dasa, Tamirat Tesfaye, Dash, Aditya Prasad, Weaver, Nicole Davis, Davitoiu, Dragos Virgil, Davletov, Kairat, De Leo, Diego, De Neve, Jan-Walter, Degefa, Meaza Girma, Degenhardt, Louisa, Degfie, Tizta Tilahun, Deiparine, Selina, Demoz, Gebre Teklemariam, Demtsu, Balem, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C, Dessie, Getenet Ayalew, Dharmaratne, Samath D, Dhimal, Meghnath, Dicker, Daniel, Ding, Eric L, Dinsa, Girmaye Deye, Djalalinia, Shirin, Do, Huyen Phuc, Dokova, Klara, Doku, David Teye, Dolan, Kate A, Doyle, Kerrie E, Driscoll, Tim R, Dubey, Manisha, 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Sudhir Kumar, Jakovljevic, Mihajlo, Jalu, Moti Tolera, James, Spencer L, Jassal, Simerjot K, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jonas, Jost B, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalani, Rizwan, Kapil, Umesh, Karami, Manoochehr, Matin, Behzad Karami, Karch, André, Karema, Corine, Karimi, Seyed M, Kasaeian, Amir, Kassa, Dessalegn H, Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassa, Zemenu Yohannes, Kassebaum, Nicholas J, Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Karyani, Ali Kazemi, Kebede, Seifu, Keiyoro, Peter Njenga, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalid, Nauman, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Khang, Young-Ho, Khanna, Tripti, Khater, Mona M, 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Samson, Levi, Miriam, Li, Shanshan, Li, Xiaohong, Li, Yichong, Liang, Juan, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Lee-Ling, Limenih, Miteku Andualem, Linn, Shai, Liu, Shiwei, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lunevicius, Raimundas, Mabika, Crispin Mabika, Macarayan, Erlyn Rachelle King, Mackay, Mark T, Madotto, Fabiana, Mahmood, Tarek Abd Elaziz, Mahotra, Narayan Bahadur, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malik, Manzoor Ahmad, Mamun, Abdullah A, Manamo, Wondimu Ayele, Manda, Ana-Laura, Mangalam, Srikanth, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Mapoma, Chabila Christopher, Marami, Dadi, Maravilla, Joemer C, Marcenes, Wagner, Marina, Shakhnazarova, Martins-Melo, Francisco Rogerlândio, März, Winfried, Marzan, Melvin B, Mashamba-Thompson, Tivani Phosa, Masiye, Felix, Mason-Jones, Amanda J, Massenburg, Benjamin Ballard, Mathur, Manu Raj, Maulik, Pallab K, Mazidi, Mohsen, McGrath, John J, Mehata, Suresh, Mehendale, Sanjay Madhav, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehrzadi, Saeed, Mehta, Kala M, Mehta, Varshil, Mekonnen, Tefera C, Meles, Hagazi Gebre, Meles, Kidanu Gebremariam, Melese, Addisu, Melku, Mulugeta, Memiah, Peter T N, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Mengistu, Getnet, Mensah, George A, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Mezgebe, Haftay Berhane, Miangotar, Yode, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Miller-Petrie, Molly Katherine, Mini, G K, Mirabi, Parvaneh, Mirica, Andreea, Mirrakhimov, Erkin M, Misganaw, Awoke Temesgen, Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadi, Moslem, Mohammadifard, Noushin, Mohammadi-Khanaposhtani, Maryam, Mohammed, Mohammed A, Mohammed, Shafiu, Mokdad, Ali H, Mola, Glen Dl, Molokhia, Mariam, Monasta, Lorenzo, Montañez, Julio Cesar, Moradi, Ghobad, Moradi, Mahmoudreza, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Morgado-Da-Costa, Joana, Mori, Rintaro, Morrison, Shane Douglas, Mosapour, Abbas, Moschos, Marilita M, Mousavi, Seyyed Meysam, Muche, Achenef Asmamaw, Muchie, Kindie Fentahun, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Muller, Kate, Murphy, Tasha B, Murthy, G V S, Musa, Jonah, Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nachega, Jean B, Nagel, Gabriele, Naghavi, Mohsen, Naheed, Aliya, Nahvijou, Azin, Naik, Gurudatta, Naik, Paulami, Najafi, Farid, Naldi, Luigi, Nangia, Vinay, Nansseu, Jobert Richie, Nascimento, Bruno Ramos, Nawaz, Haseeb, Ncama, Busisiwe P, Neamati, Nahid, Negoi, Ionut, Negoi, Ruxandra Irina, Neupane, Subas, Newton, Charles Richard James, Ngalesoni, Frida N, Ngunjiri, Josephine W, Nguyen, Grant, Nguyen, Long Hoang, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nisar, Muhammad Imran, Nixon, Molly R, Nomura, Shuhei, Noroozi, Mehdi, Noubiap, Jean Jacques, Nouri, Hamid Reza, Shiadeh, Malihe Nourollahpour, Nowroozi, Mohammad Reza, Nyandwi, Alypio, Nyasulu, Peter S, Odell, Christopher M, Ofori-Asenso, Richard, Ogah, Okechukwu Samuel, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew T, Olagunju, Tinuke O, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Sok King, Ortiz, Alberto, Osgood-Zimmerman, Aaron, Ota, Erika, Otieno, Brenda Achieng, Otstavnov, Stanislav S, Owolabi, Mayowa Ojo, Oyekale, Abayomi Samuel, P A, Mahesh, Pakhale, Smita, Pakhare, Abhijit P, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Pandey, Achyut Raj, Park, Eun-Kee, Parsian, Hadi, Patel, Shanti, Patil, Snehal T, Patle, Ajay, Patton, George C, Paturi, Vishnupriya Rao, Paudel, Deepak, Pedroso, Marcel Moraes, Peprah, Emmanuel K, Pereira, David M, Perico, Norberto, Pesudovs, Konrad, Petri, William A, Petzold, Max, Pierce, Maxwell, Pigott, David M, Pillay, Julian David, Pirsaheb, Meghdad, Polanczyk, Guilherme V, Postma, Maarten J, Pourmalek, Farshad, Pourshams, Akram, Poustchi, Hossein, Prakash, Swayam, Prasad, Narayan, Purcell, Caroline A, Purwar, Manorama B, Qorbani, Mostafa, Quansah, Reginald, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Md Shafiur, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajati, Fatemeh, Rajsic, Sasa, Ram, Usha, Ranabhat, Chhabi Lal, Ranjan, Prabhat, Rawaf, David Laith, Rawaf, Salman, Ray, Sarah E, Razo-García, Christian, Reiner, Robert C, Reis, Cesar, Remuzzi, Giuseppe, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Satar, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Riahi, Seyed Mohammad, Rios-Blancas, Maria Jesus, Roba, Kedir Teji, Roberts, Nicholas L S, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostami, Ali, Rubagotti, Enrico, Ruhago, George Mugambage, Sabde, Yogesh Damodar, Sachdev, Perminder S, Saddik, Basema, Saeedi Moghaddam, Sahar, Safari, Hosein, Safari, Yahya, Safari-Faramani, Roya, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, Haniye Sadat, Salahshoor, Mohamadreza, Salam, Nasir, Salama, Joseph S, Salamati, Payman, Saldanha, Raphael De Freitas, Saleem, Zikria, Salimi, Yahya, Salimzadeh, Hamideh, Salomon, Joshua A, Salvi, Sundeep Santosh, Salz, Inbal, Sambala, Evanson Zondani, Samy, Abdallah M, Sanabria, Juan, Sanchez-Niño, Maria Dolores, Santos, Itamar S, Santric Milicevic, Milena M, Sao Jose, Bruno Piassi, Sardana, Mayank, Sarker, Abdur Razzaque, Sarmiento-Suárez, Rodrigo, Saroshe, Satish, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Sawant, Arundhati R, Sawhney, Monika, Saxena, Sonia, Schaeffner, Elke, Schelonka, Kathryn, Schneider, Ione J C, Schwebel, David C, Schwendicke, Falk, Seedat, Soraya, Sekerija, Mario, Sepanlou, Sadaf G, Serván-Mori, Edson, Shabaninejad, Hosein, Shackelford, Katya Anne, Shafieesabet, Azadeh, Shaheen, Amira A, Shaikh, Masood Ali, Shakir, Raad A, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Sharafi, Heidar, Sharafi, Kiomars, Sharif, Mehdi, Sharif-Alhoseini, Mahdi, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikh, Aziz, Shi, Peilin, Shibuya, Kenji, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Shokraneh, Farhad, Shukla, Sharvari Rahul, Si, Si, Siabani, Soraya, Sibai, Abla Mehio, Siddiqi, Tariq J, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silpakit, Naris, Silva, Diego Augusto Santos, Silva, João Pedro, Silveira, Dayane Gabriele Alves, Singam, Narayana Sarma Venkata, Singh, Jasvinder A, Singh, Narinder Pal, Singh, Virendra, Sinha, Dhirendra Narain, Sliwa, Karen, Soares Filho, Adauto Martins, Sobaih, Badr Hasan, Sobhani, Soheila, Soofi, Moslem, Soriano, Joan B, Soyiri, Ireneous N, Sreeramareddy, Chandrashekhar T, Starodubov, Vladimir I, Steiner, Caitlyn, Stewart, Leo G, Stokes, Mark A, Strong, Mark, Subart, Michelle L, Sufiyan, Mu'awiyyah Babale, Sulo, Gerhard, Sunguya, Bruno F, Sur, Patrick John, Sutradhar, Ipsita, Sykes, Bryan L, Sylaja, P N, Sylte, Dillon O, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Tadakamadla, Santosh Kumar, Tandon, Nikhil, Tassew, Aberash Abay, Tassew, Segen Gebremeskel, Taveira, Nuno, Tawye, Nega Yimer, Tehrani-Banihashemi, Arash, Tekalign, Tigist Gashaw, Tekle, Merhawi Gebremedhin, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Teshale, Manaye Yihune, Tessema, Belay, Teweldemedhin, Mebrahtu, Thakur, Jarnail Singh, Thankappan, Kavumpurathu Raman, Thirunavukkarasu, Sathish, Thomas, Nihal, Thomson, Alan J, Tilahun, Binyam, To, Quyen G, Tonelli, Marcello, Topor-Madry, Roman, Torre, Anna E, Tortajada-Girbés, Miguel, Tovani-Palone, Marcos Roberto, Toyoshima, Hideaki, Tran, Bach Xuan, Tran, Khanh Bao, Tripathy, Srikanth Prasad, Truelsen, Thomas Clement, Truong, Nu Thi, Tsadik, Afewerki Gebremeskel, Tsegay, Amanuel, Tsilimparis, Nikolaos, Tudor Car, Lorainne, Ukwaja, Kingsley N, Ullah, Irfan, Usman, Muhammad Shariq, Uthman, Olalekan A, Uzun, Selen Begüm, Vaduganathan, Muthiah, Vaezi, Afsane, Vaidya, Gaurang, Valdez, Pascual R, Varavikova, Elena, Varughese, Santosh, Vasankari, Tommi Juhani, Vasconcelos, Ana Maria Nogales, Venketasubramanian, Narayanaswamy, Villafaina, Santos, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vosoughi, Kia, Vujcic, Isidora S, Wagnew, Fasil Shiferaw, Waheed, Yasir, Walson, Judd L, Wang, Yanping, Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey, Widecka, Justyna, Widecka, Katarzyna, Wijeratne, Tissa, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D A, Wu, Shouling, Wyper, Grant M A, Xu, Gelin, Yamada, Tomohide, Yano, Yuichiro, Yaseri, Mehdi, Yasin, Yasin Jemal, Ye, Pengpeng, Yentür, Gökalp Kadri, Yeshaneh, Alex, Yimer, Ebrahim M, Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Yousefifard, Mahmoud, Yu, Chuanhua, Zadnik, Vesna, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zare, Zohreh, Zeleke, Mulugeta Molla, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Xueying, Zhao, Xiu-Ju, Zhou, Maigeng, Zhu, Jun, Zimsen, Stephanie R M, Zodpey, Sanjay, Zoeckler, Leo, Lopez, Alan D, and Lim, Stephen S

Subjects
1. No poverty, 3. Good health

250. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Estep, Kara, Petzold, Max, Negoi, Ionut, Horino, Masako, Wiysonge, Charles Shey, Agrawal, Anurag, Takala, Jukka S., Irenso, Asnake Ararsa, Malekzadeh, Reza, Panda, Basant Kumar, Farzadfar, Farshad, Nichols, Emma, Hoy, Damian G., Mehata, Suresh, Maddison, Emilie R., Tsoi, Derrick, Awasthi, Ashish, Asayesh, Hamid, Montico, Marcella, Jeemon, Panniyammakal, Rezai, Mohammad Sadegh, Criqui, Michael H., Pakhale, Smita, Vasankari, Tommi, Ermakov, Sergey P., Yotebieng, Marcel, Heredia-Pi, Ileana Beatriz, Degenhardt, Louisa, Dey, Subhojit, Gupta, Tanush, Nachega, Jean B., Millear, Anoushka, Andrei, Catalina Liliana, Feyissa, Tesfaye Regassa, Fullman, Nancy, Tortajada, Miguel, Paulson, Katherine, Leigh, James, Kumar, Pushpendra, Santos, Itamar S., Karimi, Seyed M., Shirude, Shreya, Ding, Eric L., Roth, Gregory A., Sheikhbahaei, Sara, Mahesh, Hafezi-Nejad, Nima, Musa, Kamarul Imran, Majeed, Azeem, Bekele, Bayu Begashaw, Updike, Rachel, Jayaraman, Sudha P., Kassaw, Nigussie Assefa, Skiadaresi, Eirini, Postma, Maarten J., Nangia, Vinay, Henry, Nathaniel J., Moradi-Lakeh, Maziar, Van Boven, Job F.M., Dandona, Rakhi, Atey, Tesfay Mehari, Stokes, Mark Andrew, Dandona, Lalit, Beuran, Mircea, Logroscino, Giancarlo, Lotufo, Paulo A., Troeger, Christopher, Cowie, Benjamin C., Arora, Megha, Campuzano, Julio Cesar, Topor-Madry, Roman, Salama, Joseph, Murray, Christopher J.L., Ciobanu, Liliana G., Liu, Yang, Molokhia, Mariam, Wallin, Mitchell T., Kivimaki, Mika, Rehm, Jürgen, Gold, Audra L., Shaikh, Masood Ali, Echko, Michelle, Taveira, Nuno, Meier, Toni, Alam, Khurshid, Gillum, Richard F., Roshandel, Gholamreza, Andersen, Hjalte H., Bensenor, Isabela M., Mountjoy-Venning, Clif, Papachristou, Christina, Barboza, Miguel A., Singh, Abhishek, Chimed-Ochir, Odgerel, Hankey, Graeme J., Giref, Ababi Zergaw, Sartorius, Benn, Koyanagi, Ai, Ong, Kanyin, Opio, John Nelson, Deiparine, Selina, Mohammadi, Alireza, Tehrani-Banihashemi, Arash, Bumgarner, Blair R., Perez-Ruiz, Fernando, Lozano, Rafael, McGaughey, Madeline, Charlson, Fiona J., Kim, Daniel, Olusanya, Jacob Olusegun, Subart, Michelle, Morozof, Chloe, Mengesha, Melkamu Merid, Undurraga, Eduardo A., Javanbakht, Mehdi, Temsah, Mohamad-Hani, Mooney, Meghan D., Kemmer, Laura, Tarawneh, Mohammed Rasoul, Chisumpa, Vesper Hichilombwe, Martins-Melo, Francisco Rogerlândio, Fischer, Florian, Plass, Dietrich, Cirillo, Massimo, Kosen, Soewarta, Zaidi, Zoubida, Catalá-López, Ferrán, Okoro, Anselm, Salomon, Joshua A., Ikeda, Chad, Liu, Patrick Y., Yaseri, Mehdi, Wang, Yuan-Pang, Gesesew, Hailay Abrha, Sahathevan, Ramesh, Aboyans, Victor, He, Fei, Tobe-Gai, Ruoyan, Car, Josip, Carter, Austin, Gebregergs, Gebremedhin Berhe, Cárdenas, Rosario, Ginawi, Ibrahim Abdelmageem Mohamed, Natarajan, Gopalakrishnan, Ogbo, Felix Akpojene, Majdzadeh, Reza, Castañeda-Orjuela, Carlos A., Barker-Collo, Suzanne L., Kinfu, Yohannes, Davletov, Kairat, Asgedom, Solomon W., Xiao, Qingyang, Kassebaum, Nicholas J., Aiyar, Sneha, Sanchez-Niño, Maria Dolores, Radfar, Amir, Yaghoubi, Mohsen, Havmoeller, Rasmus, Shiri, Rahman, Sadat, Nafs, Thompson, Alex H., Zhang, Xueying, Pereira, David M., Dicker, Daniel, Jahanmehr, Nader, Jacobsen, Kathryn H., Silpakit, Naris, Filip, Irina, Ma, Stefan, Markos, Desalegn, Carrero, Juan Jesus, Hareri, Habtamu Abera, Westerman, Ronny, Strub, Bryan, Gakidou, Emmanuela, Sorensen, Reed J.D., Nong, Vuong Minh, Zenebe, Zerihun Menlkalew, Geleijnse, Johanna M., Shi, Peilin, Smith, David L., Kimokoti, Ruth W., Smith, Alison, Malta, Deborah Carvalho, Faro, André, Weiss, Daniel J., Lan, Qing, Ahmed, Muktar Beshir, Ellingsen, Christian Lycke, Hassanvand, Mohammad Sadegh, Avila-Burgos, Leticia, Barrero, Lope H., Gething, Peter W., Colombara, Danny, Johnson, Catherine O., Barquera, Simon, Alkaabi, Juma M., Deribew, Amare, Godwin, William W., Chibueze, Chioma Ezinne, Zodpey, Sanjay, Bell, Michelle L., Ärnlöv, Johan, Hammami, Mouhanad, Malhotra, Rajesh, Dargan, Paul I., Ammar, Walid, Santomauro, Damian, Bedi, Neeraj, Meretoja, Atte, Bennett, James R., Baune, Bernhard T., Alam, Noore, Hamadeh, Randah Ribhi, Mirrakhimov, Erkin M., El-Khatib, Ziad Ziad, Alvis-Guzman, Nelson, Beghi, Ettore, Adetokunboh, Olatunji, Douwes-Schultz, Dirk, Furtado, Joao M., Murthy, Gudlavalleti Venkata Satyanarayana, Fitzmaurice, Christina, Lim, Stephen S., Kulikof, Xie Rachel, Finegold, Samuel, Lorkowski, Stefan, Naldi, Luigi, Kissoon, Niranjan, Remuzzi, Giuseppe, Bikbov, Boris, Ileanu, Bogdan Vasile, Steinke, Sabine, Naheed, Aliya, Shrime, Mark G., Betsu, Balem Demtsu, Mapoma, Chabila C., Schmidt, Maria Inês, Manyazewal, Tsegahun, Barac, Aleksandra, Amoako, Yaw Ampem, Abajobir, Amanuel Alemu, Frank, Tahvi, Kasaeian, Amir, Memish, Ziad A., Milicevic, Milena M. Santric, Swaminathan, Soumya, Weintraub, Robert G., Sharma, Jayendra, Khosravi, Mohammad Hossein, Gupta, Rajeev, Hay, Simon I., Hailu, Alemayehu Desalegne, Fraser, Maya, Leung, Janni, Fernandes, João C, Purcell, Caroline, Enayati, Ahmadali, Perico, Norberto, Wakayo, Tolassa, Keiyoro, Peter Njenga, John, Denny, Cameron, Ewan, Strong, Mark, Satpathy, Maheswar, Sanabria, Juan Ramon, Schutte, Aletta E., Alam, Tahiya, Whiteford, Harvey A., Rahman, Mahfuzar, Rafay, Anwar, Lambert, Tea Lallukka Nkurunziza, Djalalinia, Shirin, Hoek, Hans W., Esteghamati, Alireza, Mohammad, Karzan Abdulmuhsin, Thrift, Amanda G., Kawakami, Norito, Vos, Theo, El Sayed Zaki, Maysaa, Fürst, Thomas, Jha, Vivekanand, Rokni, Mohammad Bagher, Nasher, Jamal T., Gebremichael, Delelegn Yilma, Muller, Kate, Kyu, Hmwe H., Meles, Kidanu Gebremariam, Sharma, Rajesh, Sur, Patrick J., Manguerra, Helena, Soneji, Samir, Lee, Paul H., Vlassov, Vasiliy Victorovich, Mruts, Kalayu Birhane, Lalloo, Ratilal, Hotez, Peter J., Amini, Erfan, Antonio, Carl Abelardo T., Alizadeh-Navaei, Reza, Pervaiz, Aslam, Osman, Majdi, Pletcher, Martin A., Genova-Maleras, Ricard, Sufyan, Muawiyyah Babale, Liu, Angela, Erskine, Holly E., Knudsen, Ann Kristin, Jakovljevic, Mihajlo B., Defo, Barthelemy Kuate, Ansari, Hossein, Anwari, Palwasha, Cooper, Cyrus, Gupta, Vipin, Morawska, Lidia, Uzochukwu, Benjamin S. Chudi, Lal, Dharmesh Kumar, Martinez-Raga, Jose, Schneider, Ione J.C., Sagar, Rajesh, Androudi, Sofa, Bulto, Lemma Negesa Bulto, Khubchandani, Jagdish, Gopalani, Sameer Vali, Alene, Kefyalew Addis, Tuzcu, Emin Murat, Srinivasan, Vinay, Venketasubramanian, Narayanaswamy, Bourne, Rupert R.A., Weiderpass, Elisabete, Pigott, David M., Horita, Nobuyuki, Abbas, Kaja M., Karimkhani, Chante, Goldberg, Ellen M., Nascimento, Bruno Ramos, Menota, Bereket Gebremichael, Altirkawi, Khalid A., Kappe, Darya Li, Ray, Sarah E., Flaxman, Abraham D., Alsharif, Ubai, Ranabhat, Chhabi Lal, Bisanzio, Donal, Olusanya, Bolajoko Olubukunola, Shahraz, Saeid, Ngunjiri, Josephine Wanjiku, Schwebel, David C., Jonas, Songhomitra, Das Neves, José, Abd-Allah, Foad, Goulart, Alessandra Carvalho, Tadakamadla, Santosh Kumar, Sligar, Amber, Shiue, Ivy, Mengistu, Desalegn Tadese, Harb, Hilda L., Hailu, Gessessew Bugssa, Ruhago, George Mugambage, Tegegne, Teketo Kassaw, Alla, François, Reiner, Robert C., Kievlan, Daniel, Marczak, Laurie B., Sepanlou, Sadaf G., De Courten, Barbora, Qorbani, Mostafa, Hambisa, Mitiku Teshome, Karch, André, Salamati, Payman, Safiri, Saeid, Whetter, Brian, Takahashi, Ken, Kiadaliri, Aliasghar Ahmad, Kim, Yun Jin, Rai, Rajesh Kumar, Wijeratne, Tissa, Levi, Miriam, Saadat, Soheil, Christopher, Devasahayam Jesudas, Hostiuc, Sorin, Zipkin, Ben, Quintanilla, Beatriz Paulina Ayala, Cahuana-Hurtado, Lucero, Gona, Philimon N., Ningrum, Dina Nur Anggraini, Wolfe, Charles D.A., Ronfani, Luca, Abbafati, Cristiana, Ali, Syed Danish, Xu, Gelin, McAlinden, Colm, Stathopoulou, Vasiliki, Rothenbacher, Dietrich, Liang, Xiaofeng, Khosravi, Ardeshir, Kabir, Zubair, Jonas, Jost B., Patton, George C., Pana, Adrian, Sykes, Bryan L., Shigematsu, Mika, Handal, Alexis J., Abera, Semaw Ferede, Nguyen, Minh, Yakob, Bereket, Patten, Scott B., Shackelford, Katya Anne, Nguyen, Cuong Tat, Meretoja, Tuomo J., Shey, Muki, Al-Aly, Ziyad, Ferrari, Alize J., Allebeck, Peter, Younis, Mustafa Z., Moraga, Paula, Mirarefn, Mojde, Sobaih, Badr H.A., Biadgilign, Sibhatu, Towbin, Jefrey Allen, Uthman, Olalekan A., Jürisson, Mikk, Abd El Razek, Mohammed Magdy, Ota, Erika, Rath, Goura Kishor, Katikireddi, Srinivasa Vittal, Deribe, Kebede, Ur Rahman, Mohammad Hifz, Ukwaja, Kingsley N., Gouda, Hebe N., Cohen, Aaron J., Naghavi, Mohsen, Aryal, Krishna Kumar, Noubiap, Jean Jacques N., Nguyen, Trang Huyen, Herteliu, Claudiu, Thomas, Katie E., Hamidi, Samer, Martopullo, Ira, Yonemoto, Naohiro, Doku, David Teye, She, Jun, Olagunju, Andrew Toyin, Li, Yongmei, Rankin, Zane, Tran, Bach Xuan, Zerfu, Taddese Alemu, Torre, Anna, Shamsizadeh, Morteza, Casey, Daniel C., Gupta, Prakash C., Alkerwi, Ala'a, Alahdab, Fares, Berhane, Adugnaw, Larsson, Anders, Iburg, Kim Moesgaard, Foigt, Nataliya, Sreeramareddy, Chandrashekhar T., Xavier, Denis, Barregard, Lars, Woldeyes, Belete Getahun, Workicho, Abdulhalik, Giussani, Giorgia, Koul, Parvaiz A., Al-Eyadhy, Ayman, Talongwa, Roberto Tchio, Soriano, Joan B., Oh, In-Hwan, Werdecker, Andrea, Garcia-Basteiro, Alberto L, Griswold, Max, Tyrovolas, Stefanos, Fereshtehnejad, Seyed-Mohammad, Rahimi-Movaghar, Vafa, Dubey, Manisha, Sachdev, Perminder S., Tabarés-Seisdedos, Rafael, Safdarian, Mahdi, Rao, Puja C., Kahsay, Amaha, Islam, Sheikh Mohammed Shariful, Nguyen, Quyen Le, Kumar, G. Anil, Morrison, Shane D., Monasta, Lorenzo, Haagsma, Juanita A., Truelsen, Thomas, Saf, Sare, Artaman, Al, Tavakkoli, Mohammad, Al-Raddadi, Rajaa, Shields, Chloe, Kesavachandran, Chandrasekharan Nair, Bienhof, Kelly, Ortiz, Alberto, Phillips, Michael Robert, Yano, Yuichiro, Hao, Yuantao, Kieling, Christian, Hancock, Jamie, Oren, Eyal, Shoman, Haitham, Pacella, Rosana E., Servan-Mori, Edson E., Polinder, Suzanne, Pinho, Christine, Steiner, Caitlyn, Thankappan, Kavumpurathu Raman, Yimam, Hassen Hamid, Vollset, Stein Emil, Schwendicke, Falk, Zegeye, Elias Asfaw, Anber, Nahla, Kadel, Rajendra, Hedayati, Mohammad T., Memiah, Peter, Gebre, Teshome, Liben, Misgan Legesse, Shamsipour, Mansour, Aichour, Amani Nidhal, Yoon, Seok-Jun, Béjot, Yannick, Huynh, Chantal, Terkawi, Abdullah Sulieman, Khan, Ejaz Ahmad, Lopez, Alan D., Thamsuwan, Ornwipa, Sunguya, Bruno F., Aichour, Miloud Taki Eddine, Pourmalek, Farshad, Paudel, Deepak, Miller, Ted R., Davitoiu, Dragos V., Lucas, Timothy C.D., Rezaei, Satar, Minnig, Shawn, Driscoll, Tim R., Balakrishnan, Kalpana, Thakur, Lodha, Rakesh, Hosgood, H. Dean, Schulhofer-Wohl, Sam, Kamal, Ritul, Khader, Yousef Saleh, Rawaf, Salman, Irvine, Caleb Mackay Salpeter, Bernabé, Eduardo, Mola, Glen Liddell D., Stein, Dan J., Bhatt, Samir, Steel, Nicholas, Smith, Mari, Rizwan, Bacha, Umar, Park, Eun-Kee, Hernandez, Julio C. Montañez, Woodbrook, Rachel, McGrath, John J., Stanaway, Jefrey D., Afshin, Ashkan, Sa Farinha, Carla Sofae, Butt, Zahid A., Lansingh, Van C., Misganaw, Awoke, Mishra, Shiva Raj, Kopec, Jacek A., Aichour, Ibtihel, Zhang, Anthony Lin, Nguyen, Grant, Thomson, Alan J., Breitborde, Nicholas J.K., Khang, Young-Ho, Olsen, Helen E., Feigin, Valery L., Silva, João Pedro, Amare, Azmeraw T., Avokpaho, Euripide Frinel G. Arthur, Kutz, Michael, Babalola, Tesleem Kayode, Mokdad, Ali H., Giroud, Maurice, Singh, Jasvinder A., Duncan, Bruce Bartholow, Violante, Francesco S., Chitheer, Abdulaal A., Johnson, Sarah Charlotte, Gebrehiwot, Tsegaye Tewelde, Mollenkopf, Sarah K., Reitsma, Marissa B., Sigfusdottir, Inga Dora, Allen, Christine, Samy, Abdallah M., Majdan, Marek, Mensah, George A., Mohammed, Shafu, Ahmadi, Alireza, Khoja, Abdullah Tawfh Abdullah, Eskandarieh, Sharareh, Macarayan, Erlyn Rachelle King, and Do, Huyen Phuc

Subjects
2. Zero hunger, 3. Good health
Abstract

BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. METHODS: We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specific causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specific deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. FINDINGS: The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72·3% (95% uncertainty interval [UI] 71·2-73·2) of deaths in 2016 with 19·3% (18·5-20·4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8·43% (8·00-8·67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16-age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1·80 million deaths (95% UI 1·59 million to 1·89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL significantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2·89%); the median annualised rate of change for all other causes was lower (a decrease of 1·59%) during the same interval. Globally, the five leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a finer level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations

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