Search

Your search keyword '"Rohani, Pejman"' showing total 797 results
Start Over Author "Rohani, Pejman"
797 results on '"Rohani, Pejman"'

206. Early childhood obesity: a survey of knowledge and practices of physicians from the Middle East and North Africa

Author

Gies, Inge, primary, AlSaleem, Bader, additional, Olang, Beheshteh, additional, Karima, Berkouk, additional, Samy, Gamal, additional, Husain, Khaled, additional, Elhalik, Mahmoud, additional, Miqdady, Mohamad, additional, Rawashdeh, Mohamad, additional, Salah, Mohamed, additional, Mouane, Nezha, additional, Rohani, Pejman, additional, Singhal, Atul, additional, and Vandenplas, Yvan, additional

Published
2017
Full Text
View/download PDF

210. Pertussis transmission in England and Wales

Author

Gay, Nigel J, Miller, Elizabeth, Rohani, Pejman, Earn, David J D, and Grenfell, Bryan T

Subjects
Pertussis vaccines -- Evaluation, Whooping-cough
Published
2000

214. 1130

Author

Gore, Amy, primary, Madbak, Firas, additional, Ho, Vanessa, additional, Rohani, Pejman, additional, Lavery, Robert, additional, Livingston, David, additional, Mohr, Alicia, additional, and Sifri, Ziad, additional

Published
2015
Full Text
View/download PDF

222. An Iranian Consensus Document for Nutrition in Critically Ill Patients, Recommendations and Initial Steps toward Regional Guidelines.

Author

Hashemian, Seyed Mohammadreza, Martindale, Robert G., Jamaati, Hamidreza, Amirsavadkouhi, Ali, Azer, Salahaddin Mahmudi, Shadnoush, Mahdi, Ardehali, Seyed Hossein, Najafi, Atabak, Ahmadi, Arezoo, Seyyedi, Seyyed Reza, Mahmoodpoor, Ata, Moradi, Omid, Abbasi, Saeed, Hosseini, Saeed, Shahrami, Reza, Abdi, Saeed, Sepehri, Zahra, Omranirad, Babak, Mohajerani, Seyed Amir, and Rohani, Pejman

Subjects
CRITICALLY ill, NUTRITION
Published
2017

223. Forecasting Epidemiological Consequences of Maternal Immunization.

Author

Bento, Ana I. and Rohani, Pejman

Subjects
*IMMUNIZATION, *PREGNANT women, *EPIDEMIOLOGY, *WHOOPING cough vaccines, *IMMUNOGLOBULINS
Abstract

Background. The increase in the incidence of whooping cough ( pertussis) in many countries with high vaccination coverage is alarming. Maternal pertussis immunization has been proposed as an effective means of protecting newborns during the interval between birth and the first routine dose. However, there are concerns regarding potential interference between maternal antibodies and the immune response elicited by the routine schedule, with possible long-term population-level effects. Methods. We formulated a transmission model comprising both primary routine and maternal immunization. This model was examined to evaluate the long-term epidemiological effects of routine and maternal immunization, together with consequences of potential immune interference scenarios. Results. Overall, our model demonstrates that maternal immunization is an effective strategy in reducing the incidence of pertussis in neonates prior to the onset of the primary schedule. However, if maternal antibodies lead to blunting, incidence increases among older age groups. For instance, our model predicts that with 60% routine and maternal immunization coverage and 30% blunting, the incidence among neonates (0–2 months) is reduced by 43%. Under the same scenario, we observe a 20% increase in incidence among children aged 5–10 years. However, the downstream increase in the older age groups occurs with a delay of approximately a decade or more. Conclusions. Maternal immunization has clear positive effects on infant burden of disease, lowering mean infant incidence. However, if maternally derived antibodies adversely affect the immunogenicity of the routine schedule, we predict eventual population- level repercussions that may lead to an overall increase in incidence in older age groups. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

233. Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

Author

Sharma, Mehul, Leung, Daniel, Momenilandi, Mana, Jones, Lauren C.W., Pacillo, Lucia, James, Alyssa E., Murrell, Jill R., Delafontaine, Selket, Maimaris, Jesmeen, Vaseghi-Shanjani, Maryam, Del Bel, Kate L., Lu, Henry Y., Chua, Gilbert T., Di Cesare, Silvia, Fornes, Oriol, Liu, Zhongyi, Di Matteo, Gigliola, Fu, Maggie P., Amodio, Donato, Tam, Issan Yee San, Chan, Gavin Shueng Wai, Sharma, Ashish A., Dalmann, Joshua, van der Lee, Robin, Blanchard-Rohner, Géraldine, Lin, Susan, Philippot, Quentin, Richmond, Phillip A., Lee, Jessica J., Matthews, Allison, Seear, Michael, Turvey, Alexandra K., Philips, Rachael L., Brown-Whitehorn, Terri F., Gray, Christopher J., Izumi, Kosuke, Treat, James R., Wood, Kathleen H., Lack, Justin, Khleborodova, Asya, Niemela, Julie E., Yang, Xingtian, Liang, Rui, Kui, Lin, Wong, Christina Sze Man, Poon, Grace Wing Kit, Hoischen, Alexander, van der Made, Caspar I., Yang, Jing, Chan, Koon Wing, Rosa Duque, Jaime Sou Da, Lee, Pamela Pui Wah, Ho, Marco Hok Kung, Chung, Brian Hon Yin, Le, Huong Thi Minh, Yang, Wanling, Rohani, Pejman, Fouladvand, Ali, Rokni-Zadeh, Hassan, Changi-Ashtiani, Majid, Miryounesi, Mohammad, Puel, Anne, Shahrooei, Mohammad, Finocchi, Andrea, Rossi, Paolo, Rivalta, Beatrice, Cifaldi, Cristina, Novelli, Antonio, Passarelli, Chiara, Arasi, Stefania, Bullens, Dominique, Sauer, Kate, Claeys, Tania, Biggs, Catherine M., Morris, Emma C., Rosenzweig, Sergio D., O’Shea, John J., Wasserman, Wyeth W., Bedford, H. Melanie, van Karnebeek, Clara D.M., Palma, Paolo, Burns, Siobhan O., Meyts, Isabelle, Casanova, Jean-Laurent, Lyons, Jonathan J., Parvaneh, Nima, Nguyen, Anh Thi Van, Cancrini, Caterina, Heimall, Jennifer, Ahmed, Hanan, McKinnon, Margaret L., Lau, Yu Lung, Béziat, Vivien, and Turvey, Stuart E.

Abstract

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We have identified 16 patients from 10 families spanning three continents with a profound phenotype of early-life onset allergic immune dysregulation, widespread treatment-resistant atopic dermatitis, hypereosinophilia with esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, and anaphylaxis. The cases were either sporadic (seven kindreds) or followed an autosomal dominant inheritance pattern (three kindreds). All patients carried monoallelic rare variants in STAT6 and functional studies established their gain-of-function (GOF) phenotype with sustained STAT6 phosphorylation, increased STAT6 target gene expression, and TH2 skewing. Precision treatment with the anti–IL-4Rα antibody, dupilumab, was highly effective improving both clinical manifestations and immunological biomarkers. This study identifies heterozygous GOF variants in STAT6 as a novel autosomal dominant allergic disorder. We anticipate that our discovery of multiple kindreds with germline STAT6 GOF variants will facilitate the recognition of more affected individuals and the full definition of this new primary atopic disorder.

Published
2023
Full Text
View/download PDF

242. Charting the spatial dynamics of early SARS-CoV-2 transmission in Washington state.

Author

Brett, Tobias S., Bansal, Shweta, and Rohani, Pejman

Subjects
*SARS-CoV-2, *COVID-19, *INFERENTIAL statistics, *HIERARCHICAL clustering (Cluster analysis), *EPIDEMICS, *INFECTIOUS disease transmission, *COMMUNICABLE diseases
Abstract

The spread of SARS-CoV-2 has been geographically uneven. To understand the drivers of this spatial variation in SARS-CoV-2 transmission, in particular the role of stochasticity, we used the early stages of the SARS-CoV-2 invasion in Washington state as a case study. We analysed spatially-resolved COVID-19 epidemiological data using two distinct statistical analyses. The first analysis involved using hierarchical clustering on the matrix of correlations between county-level case report time series to identify geographical patterns in the spread of SARS-CoV-2 across the state. In the second analysis, we used a stochastic transmission model to perform likelihood-based inference on hospitalised cases from five counties in the Puget Sound region. Our clustering analysis identifies five distinct clusters and clear spatial patterning. Four of the clusters correspond to different geographical regions, with the final cluster spanning the state. Our inferential analysis suggests that a high degree of connectivity across the region is necessary for the model to explain the rapid inter-county spread observed early in the pandemic. In addition, our approach allows us to quantify the impact of stochastic events in determining the subsequent epidemic. We find that atypically rapid transmission during January and February 2020 is necessary to explain the observed epidemic trajectories in King and Snohomish counties, demonstrating a persisting impact of stochastic events. Our results highlight the limited utility of epidemiological measures calculated over broad spatial scales. Furthermore, our results make clear the challenges with predicting epidemic spread within spatially extensive metropolitan areas, and indicate the need for high-resolution mobility and epidemiological data. Author summary: Geographic structure in human populations has been widely recognised as a key determinant in the spread of infectious diseases, however the mechanisms underlying it are hard to disentangle. Using two distinct statistical analyses, we sought to address questions surrounding the impact of movement patterns and stochastic events on the spatial spread of SARS-CoV-2 in Washington state. Through our first analysis, which made use of a clustering algorithm, we uncovered a relationship between spatial proximity and the similarity of epidemic trajectories. Clusters of similar trajectories formed a clear geographical pattern. In our second analysis, we performed statistical inference on time series data from the Puget Sound region of Washington state. From our inference, we found that both a high degree of connectivity and atypically fast transmission within the first few weeks of the outbreak were necessary to explain the rapid inter-county spread. Furthermore, this stochastic early spread had a lasting effect on the subsequent epidemic course as non-pharmaceutical interventions were insufficient to temporarily eradicate the virus from the region. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

244. Ecological and anthropogenic drivers of rabies exposure in vampire bats: implications for transmission and control

Author

Streicker, Daniel G., primary, Recuenco, Sergio, additional, Valderrama, William, additional, Gomez Benavides, Jorge, additional, Vargas, Ivan, additional, Pacheco, Víctor, additional, Condori Condori, Rene E., additional, Montgomery, Joel, additional, Rupprecht, Charles E., additional, Rohani, Pejman, additional, and Altizer, Sonia, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results