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207. High-Intensity Postacute Care at Home

Author

Johnson, Joshua K., primary, Hohman, Jessica A., additional, Vakharia, Nirav, additional, Zafirau, William, additional, Stilphen, Mary, additional, Pamer, Steven, additional, Marzulli, Jessica, additional, Zimbroff, Robert, additional, and Rothberg, Michael B., additional

Published
2021
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225. Association of corticosteroid dose and route of administration with risk of treatment failure in acute exacerbation of chronic obstructive pulmonary disease

Author

Lindenauer, Peter K., Yoojin Lee, Benjamin, Evan M., Rothberg, Michael B., Pekow, Penelope S., and Lahti, Maureen C.

Subjects
Lung diseases, Obstructive -- Risk factors, Lung diseases, Obstructive -- Drug therapy, Lung diseases, Obstructive -- Patient outcomes, Corticosteroids -- Dosage and administration
Abstract

A study was conducted to evaluate and compare the outcomes of patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (COPD) treated with low doses of corticosteroids administered orally as against those treated with higher doses intravenously. Results indicated that orally administered steroids did not have worse outcomes as compared to intravenously administered ones.

Published
2010

226. Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease

Author

Rothberg, Michael B., Pekow, Penelope S., Lahti, Maureen, Brody, Oren, Skiest, Daniel J., and Lindenauer, Peter K.

Subjects
Antibiotics -- Usage, Antibiotics -- Health aspects, Lung diseases, Obstructive -- Diagnosis, Lung diseases, Obstructive -- Drug therapy, Lung diseases, Obstructive -- Patient outcomes, Multilevel analysis -- Usage
Abstract

A study was conducted to evaluate and compare the outcomes for patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) treated with antibiotics in the first 2 days of admission as against those treated later or not at all. Results indicated that early administration of antibiotics led to better and more improved outcomes in the case of such patients.

Published
2010

235. Association of antibiotic use and acute kidney injury in patients hospitalized with community-acquired pneumonia.

Author

Le, Phuc, Navaneethan, Sankar Dass, Yu, Pei-Chun, Pallotta, Andrea M., Rastogi, Radhika, Patel, Preethi, Brateanu, Andrei, Imrey, Peter B., and Rothberg, Michael B.

Subjects
ACUTE kidney failure, COMMUNITY-acquired pneumonia, ANTIBIOTICS, RANDOM effects model, CEPHALOSPORINS, INTENSIVE care units
Abstract

Acute kidney injury (AKI) is common among hospitalized patients with community-acquired pneumonia (CAP). We aimed to estimate and compare the risk of AKI for various antibiotic combinations in adults hospitalized for CAP. We conducted a retrospective cohort study of the Premier Healthcare Database containing all admissions for 660 US hospitals from 2010 to 2015. We included adults aged ≥18 years hospitalized with CAP and considered 6 different antibiotic combinations based on continuous use in the first 3 hospital days. The primary outcome was incident AKI, defined by ICD-9 codes 584.5-584-9. We evaluated associations of AKI with in-hospital mortality and length-of-stay. We excluded patients who were admitted directly to the intensive care unit, had AKI codes present on admission or had dialysis in the first 2 days. We used generalized linear mixed models with the hospital as a random effect and covariate adjustment for patient demographics, comorbidities, other treatments on day 0/1, and hospital characteristics. The total sample included 449,535 patients, 3.15% of whom developed AKI. All other regimens but fluoroquinolones exhibited higher AKI odds than 3rd generation cephalosporin with or without macrolide. The combination of piperacillin/tazobactam and vancomycin with or without other antibiotics was associated with the highest AKI odds (OR = 1.89; 95% CI: 1.73–2.06). Patients with incident AKI had an increased odds of hospital mortality (OR = 6.37; 95% CI: 6.07–6.69) and longer length-of-stay (mean multiplier = 1.84; 95% CI: 1.82, 1.86). Compared to 3rd generation cephalosporin with or without macrolide, piperacillin/tazobactam, vancomycin, and their combination were associated with higher odds of developing AKI, which in turn were associated with worse clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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241. Pathologic Complete Response to Neoadjuvant Nivolumab/Ipilimumab in a Patient with Metastatic Renal Cell Carcinoma

Author

Peak, Taylor C., Fenu, Elena M., Rothberg, Michael B., Thomas, Christopher Y., Davis, Ronald L., and Levine, Edward A.

Subjects
Article Subject, urologic and male genital diseases
Abstract

Nivolumab plus ipilimumab represents an effective combination of checkpoint inhibitors that can lead to a durable response with minimal toxicity in patients with metastatic renal cell carcinoma (mRCC). We present a case of a pathologic complete response to neoadjuvant nivolumab plus ipilimumab in a patient with a 13.9 cm left renal mass and significant retroperitoneal and iliac lymphadenopathy, classified as intermediate-risk mRCC. We discuss and review the literature on complete responses after systemic therapy and the ability to predict who has undergone a complete response in the face of residual radiographic evidence of disease.

Published
2020
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242. Appendix_MDM-19-501-R1_8-4-2020_online_supp – Supplemental material for Opportunities, Pitfalls, and Alternatives in Adapting Electronic Health Records for Health Services Research

Author

Taksler, Glen B., Dalton, Jarrod E., Perzynski, Adam T., Rothberg, Michael B., Milinovich, Alex, Krieger, Nikolas I., Dawson, Neal V., Roach, Mary J., and Einstadter, Douglas

Subjects
111708 Health and Community Services, 111799 Public Health and Health Services not elsewhere classified, 160807 Sociological Methodology and Research Methods, FOS: Health sciences, FOS: Sociology
Abstract

Supplemental material, Appendix_MDM-19-501-R1_8-4-2020_online_supp for Opportunities, Pitfalls, and Alternatives in Adapting Electronic Health Records for Health Services Research by Glen B. Taksler, Jarrod E. Dalton, Adam T. Perzynski, Michael B. Rothberg, Alex Milinovich, Nikolas I. Krieger, Neal V. Dawson, Mary J. Roach and Douglas Einstadter in Medical Decision Making

Published
2020
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243. Outcomes of care by hospitalists, general internists, and family physicians

Author

Linenauer, Peter K., Rothberg, Michael B., Pekow, Penelope S., Kenwood, Christopher, Benjamin, Evan M., and Auerbach, Andrew D.

Subjects
Hospitalists -- Practice, Hospitalists -- Evaluation, Patients -- Care and treatment, Patients -- Evaluation
Abstract

A study to compare the outcomes of care of hospitalized patients throughout the U.S. by hospitalists, general internists and family physicians is conducted. Findings show hospitalist care modestly less expensive than that provided by general internists, but it offers no significant savings as compared with the care provided by family physicians.

Published
2007

246. Public reporting and pay for performance in hospital quality improvement

Author

Lindenauer, Peter K. and Rothberg, Michael B.

Subjects
Pay for performance -- Reports, Public health -- Reports, Medical care -- Quality management, Medical care -- Analysis
Abstract

An analysis of a national public-reporting initiative was conducted to evaluate whether combining pay for performance with public reporting results in improvement in quality of safety and health care in hospitals than public reporting alone. Results revealed that hospitals engaged in both public reporting and pay for performance achieved modest improvements in quality than those engaged only in public reporting.

Published
2007

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