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The traditional power grid planning lacks consideration of the uncertainty and correlation between wind and solar joint output in the same region, which poses challenges to the stable operation of the power system. Therefore, it is greatly important to consider the environmental and economic dispatch in light of the uncertainties and correlations associated with wind and solar energy. To tackle these issues, this paper introduces a dynamic environmental economic dispatch model that accounts for the uncertainties and correlations between wind and photovoltaic power based on their output characteristics. Initially, a probability model for photovoltaic–wind joint power is established using the Copula function. Subsequently, the Latin hypercube sampling method is employed alongside an improved K-means clustering technique to derive typical output scenarios. An adaptive multi-objective fireworks algorithm, featuring a differential selection strategy, is then utilized to enhance the environmental economic dispatch model. Finally, the IEEE 39 node system is used as an example to demonstrate the solution of the dynamic environmental and economic scheduling model. Simulation results reveal that the method for generating typical output scenarios presented in this paper effectively captures the uncertainties and correlations of photovoltaic–wind joint power. Furthermore, when compared to other optimization algorithms, the improved adaptive multi-objective fireworks algorithm proves to be more efficient in addressing the dynamic environmental economic dispatch challenges within the power system. [ABSTRACT FROM AUTHOR]

Background: The COVID-19 pandemic profoundly impacted medical education and caused psychological distress and worry about clinical learning for those who received clinical medical education during this period. Although the acute phase of COVID-19 has now ended, understanding its impact is essential for strengthening medical system preparedness. Therefore, the present study examined the association between changes in medical education and worry about clinical learning, considering the mediating role of psychological distress among participants who received clinical training. Methods: A cross-sectional online survey was conducted with 542 post-graduate year (PGY) doctors and allied health students from the 2020 and 2021 cohorts in Taiwan. The survey assessed changes in clinical training modes, direct patient care, learning stress, psychological distress, and worry about clinical learning. Results: Among the participants, 76.0% experienced changes in clinical training mode, and 84.3% had direct patient care experience. Direct patient care/contact was significantly correlated with lower levels of worry about clinical learning. Learning stress was positively correlated with increased psychological distress and worry about clinical learning. Psychological distress partially mediated the relationship between learning stress and worry about clinical learning. Conclusion: The findings highlight the importance of direct contact with patients because it was associated with lower levels of worry about clinical learning. Moreover, increased learning stress was associated with psychological distress and worry about clinical learning. Therefore, effective support systems are essential to mitigate these impacts and enhance clinical training during national health crises. The findings provide valuable insights for improving medical education and support systems in future health emergencies. However, the present study used a cross-sectional study design. Therefore, the mediation findings should be interpreted with caution (i.e., no causal relationships can be determined based on cross-sectional data). [ABSTRACT FROM AUTHOR]

The timely recognition of pneumothorax during painless flexible bronchoscopy (PFB) can be challenging. This report describes two consecutive cases of pneumothorax following PFB, both of which were promptly identified and successfully treated. A sudden decrease in heart rate, combined with hypoxemia, is highly effective for detecting pneumothorax in patients undergoing PFB, with subcutaneous emphysema serving as a key auxiliary diagnostic sign. Remimazolam may provide significant clinical benefits in emergency situations during PFB by allowing patients to be quickly awakened to assist with diagnosis. [ABSTRACT FROM AUTHOR]

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality and drug resistance and no targeted drug available at present. Compound 4, a staurosporine alkaloid derived from Streptomyces sp. NBU3142 in a marine sponge, exhibits potent anti-TNBC activity. This research investigated its impact on MDA-MB-231 cells and their drug-resistant variants. The findings highlighted that compound 4 inhibits breast cancer cell migration, induces apoptosis, arrests the cell cycle, and promotes cellular senescence in both regular and paclitaxel-resistant MDA-MB-231 cells. Additionally, this study identified mitogen-activated protein kinase kinase kinase 11 (MAP3K11) as a target of compound 4, implicating its role in breast tumorigenesis by affecting cell proliferation, migration, and cell cycle progression. [ABSTRACT FROM AUTHOR]