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2,241 results on '"Rush, A. John"'

201. Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression. (Original Article)

Author

Thase, Michael E., Rush, A. John, Howland, Robert H., Kornstein, Susan G., Kocsis, James H., Gelenberg, Alan J., Schatzberg, Alan F., Koran, Lorrin M., Keller, Martin B., Russell, James M., Hirschfeld, Robert M.A., LaVange, Lisa M., Klein, Daniel N., Fawcett, Jan, and Harrison, Wilma

Subjects
Imipramine -- Testing, Sertraline -- Testing, Antidepressants -- Testing, Chronic diseases -- Drug therapy, Depression, Mental -- Drug therapy, Drug therapy -- Testing, Experimental design -- Usage, Health, Psychology and mental health
Published
2002

217. Genome-wide association study of suicide attempts in mood disorder patients

Author

Perils, Roy H., Huang, Jie, Purcell, Shaun, Fava, Maurizio, Rush, A. John, Sullivan, Patrick F., Hamilton, Steven P., McMahon, Francis J., Schulze, Thomas, Potash, James B., Zandi, Peter P., Willour, Virginia L., Penninx, Brenda W., Boomsma, Dorret I., Vogelzangs, Nicole, Middeldorp, Christel M., Rietschel, Marcella, Nothen, Markus, Cichon, Sven, Gurling, Hugh, Bass, Nick, McQuillin, Andrew, Hamshere, Marian, Craddock, Nick, Sklar, Pamela, and Smoller, Jordan W.

Subjects
Affective disorders -- Genetic aspects, Affective disorders -- Diagnosis, Suicidal behavior -- Diagnosis, Suicidal behavior -- Genetic aspects, Health, Psychology and mental health
Abstract

Objective: Family and twin studies suggest that liability for suicide attempts is heritable and distinct from mood disorder susceptibility. The authors therefore examined the association between common genomewide variation and lifetime suicide attempts. Method: The authors analyzed data on lifetime suicide attempts from genomewide association studies of bipolar I and II disorder as well as major depressive disorder. Bipolar disorder subjects were drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder cohort, the Wellcome Trust Case Control Consortium bipolar cohort, and the University College London cohort. Replication was pursued in the NIMH Genetic Association Information Network bipolar disorder project and a German clinical cohort. Depression subjects were drawn from the Sequential Treatment Alternatives to Relieve Depression cohort, with replication in the Netherlands Study of Depression and Anxiety/Netherlands Twin Register depression cohort. Results: Strongest evidence of association for suicide attempt in bipolar disorder was observed in a region without identified genes (rs1466846); five loci also showed suggestive evidence of association. In major depression, strongest evidence of association was observed for a single nucleotide polymorphism in ABI3BP, with six loci also showing suggestive association. Replication cohorts did not provide further support for these loci. However, meta-analysis incorporating approximately 8,700 mood disorder subjects identified four additional regions that met the threshold for suggestive association, including the locus containing the gene coding for protein kinase C-epsilon, previously implicated in models of mood and anxiety. Conclusions: The results suggest that inherited risk for suicide among mood disorder patients is unlikely to be the result of individual common variants of large effect. They nonetheless provide suggestive evidence for multiple loci, which merit further investigation. doi: 10.1176/appi.ajp.2010.10040541

Published
2010

220. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression

Author

Huang, Jie, Perlis, Roy H., Lee, Phil H., Rush, A. John, Fava, Maurizio, Sachs, Gary S., Lieberman, Jeffrey, Hamilton, Steven P., Sullivan, Patrick, Sklar, Pamela, Purcell, Shaun, and Smoller, Jordan W.

Subjects
Bipolar disorder -- Genetic aspects, Schizophrenia -- Genetic aspects, Depression, Mental -- Genetic aspects, Health, Psychology and mental health
Abstract

Objective: Family and twin studies indicate substantial overlap of genetic influences on psychotic and mood disorders. Linkage and candidate gene studies have also suggested overlap across schizophrenia, bipolar disorder, and major depressive disorder. The purpose of this study was to apply genomewide association study (GWAS) analysis to address the specificity of genetic effects on these disorders. Method: The authors combined GWAS data from three large effectiveness studies of schizophrenia (CATIE, genotyped: N=741), bipolar disorder (STEP-BD, genotyped: N=1,575), and major depressive disorder (STAR*D, genotyped: N=1,938) as well as from psychiatrically screened control subjects (NIMH-Genetics Repository: N=1,204). A two-stage analytic procedure involving an omnibus test of allele frequency differences among case and control groups was applied, followed by a model selection step to identify the best-fitting model of allelic effects across disorders. Results: The strongest result was seen for a single nucleotide polymorphism near the adrenomedullin (ADM) gene (rs6484218), with the best-fitting model indicating that the effect was specific to bipolar II disorder. Findings also revealed evidence suggesting that several genes may have effects that transcend clinical diagnostic boundaries, including variants in NPAS3 that showed pleiotropic effects across schizophrenia, bipolar disorder, and major depressive disorder. Conclusions: This study provides the first genomewide significant evidence implicating variants near the ADM gene on chromosome 11pl 5 in psychopathology, with effects that appear to be specific to bipolar II disorder. Although genomewide significant evidence of cross-disorder effects was not detected, the results provide evidence that there are both pleiotropic and disorder-specific effects on major mental illness and illustrate an approach to dissecting the genetic basis of mood and psychotic disorders that can inform future large-scale cross-disorder GWAS analyses.

Published
2010

223. Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder

Author

Perlis, Roy H., Smoller, Jordan W., Mysore, Jayalakshmi, Sun, Mei, Gillis, Tammy, Purcell, Shaun, Rietschel, Marcella, Nothen, Markus M., Witt, Stephanie, Maier, Wolfgang, Iosifescu, Dan V., Sullivan, Patrick, Rush, A. John, Fava, Maurizio, Breiter, Hans, Macdonald, Marcy, and Gusella, James

Subjects
Huntington's chorea -- Diagnosis, Prevalence studies (Epidemiology) -- Methods, Prevalence studies (Epidemiology) -- Usage, Allelomorphism -- Health aspects, Major depressive disorder -- Development and progression, Health, Psychology and mental health
Abstract

Objective: Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established. Method: This was a case-control genetic association study of HTT CAG allele size in two discovery cohorts of individuals with major depressive disorder and comparison subjects without major depression as well as a replication cohort of individuals with major depression and comparison subjects without major depression. Results: CAG repeat lengths of 36 or greater were observed in six of 3,054 chromosomes from individuals with major depression, compared with none of 4,155 chromosomes from comparison subjects. In a third cohort, one expanded allele was observed among 1,202 chromosomes in the major depression group, compared with none of 2,678 chromosomes in comparison subjects. No clear pattern of clinical features was shared among individuals with the expanded repeats. Conclusions: In clinical populations of individuals diagnosed with major depression, approximately 3 in 1,000 carried expanded HTT CAG alleles.

Published
2010

244. Clinically Relevant Findings from STAR*D

Author

Rush, A. John, Kilner, Jon, Fava, Maurizio, Wisniewski, Stephen R., Warden, Diane, Nierenberg, Andrew A., and Trivedi, Madhukar H.

Published
2008

249. Effect of Age at Onset on the Course of Major Depressive Disorder

Author

Zisook, Sidney, Lesser, Ira, Stewart, Jonathan W., Wisniewski, Stephen R., Balasubramani, G. K., Fava, Maurizio, Gilmer, William S., Dresselhaus, Timothy R., Thase, Michael E., Nierenberg, Andrew A., Trivedi, Madhukar H., and Rush, A. John

Published
2007

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