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988 results on '"Sacchi, S"'

203. DIAGNOSTIC POTENTIAL OF CD38 COMBINED WITH ZAP70 EXPRESSION IN PREDICTING MUTATIONAL STATUS OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION IN CHRONIC LYMPHOCYTIC LEUKEMIA: PRELIMINARY RESULTS OF A PROSPECTIVE, MULTICENTER O-CLL1- GISL STUDY

Author

Gentile, M., Cutrona, G., Matis, S., Fabris, S., Pedemonte, S., Pesce, E. A., Di Raimondo, F., Musolino, C., Gobbi, M., Di Renzo, N., Mauro, Francesca Romana, Cantaffa, R., Brugiatelli, M., Merli, F., Zupo, S., Mammi, C., Baldini, L., Angrilli, F., Quintana, G., Consoli, U., Bertoldero, G., Iannitto, E., Di Tonno, P., Fragasso, A., Molica, S., Musto, P., Cox, M. C., Festini, G., Callea, V., Sacchi, S., Cortelezzi, A., Foa, Roberto, Federico, M., Neri, A., Ferrarini, M., and Morabito, F.

Published
2009

206. INCIDENCE OF CYTOGENETIC ABNORMALITIES IN NEWLY DIAGNOSED BINET STAGE A B-CLL AND RELATIONSHIP WITH PROGNSOTIC BIOMARKERS: PRELIMINARY RESULTS ON 240 PATIENTS INCLUDED IN THE PROSPECTIVE, MULTICENTER O-CLL1 GISL STUDY

Author

Fabris, S, Cutrona, G, Gentile, M, Matis, S, Pesce, E. A., DI RAIMONDO, Francesco, Musolino, C, Gobbi, M, DI RENZO, N, Mauro, F. R., Cantaffa, R, Brugiatelli, M, Merli, F, Zupo, S, Mammi, C, Baldini, L, Angrilli, F, Quintana, G, Consoli, U, Bertoldero, G, Iannitto, E, DI TONNO, P, Fragasso, A, Molica, S, Musto, P, Cox, M. C., Festini, G, Callea, V, Sacchi, S, Cortellezzi, A, LAMBERTENGHI DELILIERS, G, FEDERICO M, FOÀ R., Ferrarini, M, Morabito, F, and Neri, A.

Published
2009

207. INCLUSION OF TOTAL BODY CT SCAN IN THE INITIAL WORK-UP OF CLL PATIENTS WITH EARLY-STAGE ON CLINICAL GROUNDS: PRELIMINARY RESULTS OF A PROSPECTIVE, MULTICENTER O-CLL1- GISL STUDY

Author

Gentile, M., Giovanna Cutrona, Fabris, S., Pesce, E., Di Raimondo, F., Di Renzo, N., Mauro, F. R., Cantaffa, R., Brugiatelli, M., Merli, F., Baldini, L., Quintana, G., Iannitto, E., Di Tonno, P., Fragasso, A., Molica, S., Callea, V., Sacchi, S., Federico, M., Neri, A., Ferrarini, M., and Morabito, F.

Subjects
nd
Published
2009

210. Variation in individual job opportunities

Author

Kriesi, I, Buchmann, M, Sacchi, S, and University of Zurich

Subjects
300 Social sciences, sociology & anthropology, 370 Education, 10190 Jacobs Center for Productive Youth Development, 10095 Institute of Sociology
Published
2008

217. pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility

Author

Sacchi, S, Bernasconi, M, Martineau, M, Mothet, Jp, Ruzzene, Maria, Pilone, Ms, Pollegioni, L, and Molla, G.

Subjects
D-Amino-Acid Oxidase, Swine, Intracellular Signaling Peptides and Proteins, Carboxypeptidases, Kidney, Transfection, Cell Line, Tumor, Enzyme Stability, Flavin-Adenine Dinucleotide, Schizophrenia, Serine, Animals, Humans, Carrier Proteins, Cells, Cultured, Protein Binding
Abstract

Human genes coding for pLG72 and d-amino acid oxidase have recently been linked to the onset of schizophrenia. pLG72 was proposed as an activator of the human FAD-containing flavoprotein d-amino acid oxidase (hDAAO). In the brain this oxidizes d-serine, a potent activator of N-methyl-d-aspartate receptor. We have investigated the mechanistic regulation of hDAAO by pLG72. Immunohistochemical analyses revealed that hDAAO and pLG72 are both expressed in astrocytes of the human cortex, where they most likely interact, considering their partial overlapping subcellular distribution and their coimmunoprecipitation. We demonstrated that the specific in vitro interaction of the two proteins yields a complex composed of 2 hDAAO homodimers and 2 pLG72 molecules. Binding of pLG72 did not affect the kinetic properties and FAD binding ability of hDAAO; instead, a time-dependent loss of hDAAO activity in the presence of an excess of pLG72 was found. The binding affects the tertiary structure of hDAAO, altering the amount of the active form. We finally demonstrated that overexpression of hDAAO in glioblastoma cells decreases the levels of d-serine, an effect that is null when pLG72 is coexpressed. These data indicate that pLG72 acts as a negative effector of hDAAO. Therefore, a decrease in the synaptic concentration of d-serine as the result of an anomalous increase in hDAAO activity related to hypoexpression of pLG72 may represent a molecular mechanism by which hDAAO and pLG72 are involved in schizophrenia susceptibility.

Published
2008

218. Role of thalidomide in previously untreated patients with multiple myeloma

Author

Musto, P, D'Auria, F, Pietrantuono, G, Bringhen, S, Morabito, F, Di Raimondo, F, Pozzi, S, Sacchi, S, Boccadoro, Mario, Palumbo, Antonio, Gruppo Italiano Malatte Ematologiche dell'Adulto Multiple Myeloma Working Party, Italian Myeloma Network, and Gruppo Italiano Studio Linfomi

Published
2008

222. BISPHOSPHONATES (BP) RELATED OSTEONECROSIS OF THE JAW (ONJ): A LONG TERM FOLLOW UP (FU) OF A SERIES OF 35 CASES OBSERVED BY GISL

Author

Samantha Pozzi, Marcheselli, R., Sacchi, S., Baldini, L., Angrilli, F., Falorio, S., Ouarta, G., Stelitano, C., Caparotti, G., Luminari, S., Falcone, A., Natale, D., Broglia, Ch, Cuoghi, A., Dini, D., Ditonno, P., Leonardi, G., Pianezze, G., Pitini, V., Polimeno, G., Ponchio, L., Masini, L., Maurizio, M., Spriano, M., and Musto, P.

Subjects
BISPHOSPHONATES
Published
2008

234. BORTEZOMIB AND PLASMA CELL LEUKEMIA

Author

Musto, P., Barone, M., Guariglia, R., Pietrantuono, G., Gay, F., Rossini, F., Guglielmelli, T., Pitini, Vincenzo, Ferrara, F., Galli, M., Falcone, A., Pozzi, S., Dauria, F., Sacchi, S., and Palumbo, M. BOCCADORO AND A.

Published
2006

238. Bone Marrow evaluation according to the PVSG and WHO criteria in 90 essential thrombocythemia (ET) patients treated with PEG interferon alpha-2b. Preliminary results

Author

Luigi, Gugliotta, Bulgarelli, S., Asioli, S., Tieghi, A., Gardini, G., Sabattini, E., Franco, V., Boveri, E., Kvasnicka, H. M., Vinelli, N., Candoni, A., LA TAGLIATA, R., Passamonti, F., Rupoli, S, Martinelli, V., Zaccaria, A., Lauria, F., DE BIASI, E., Sacchi, S., Gobbi, M., Tabi, A., Lio, Cacciola, E., Cacciola, Rossella Rosaria, Grossi, A., Mazza, P., Bonifazi, F., Favoni, P., Mandelli, F., Baccarani, M, and Thiele, J.

Published
2005

240. PEG Intron treatment in 90 patients with assential thrombocithemia (ET) final report of a phase II study

Author

Luigi, Gugliotta, Bulgarelli, S., Vinelli, N., Russo, D., Candoni, A., Rupoli, S., LA TAGLIATA, R., Sacchi, S., Martinelli, V., DE BIASI, E., Bucalossi, A., Mazzotta, S., Tabilio, A., Passamonti, F., Grossi, A., Cacciola, Emma, Cacciola, R., Pogliani, E., Bonifazi, F., Fanin, R., Leoni, P., Mandelli, F., Zaccaria, A., Lauria, F., Lazzarino, M., Gobbi, M., Bosi, A., Mazza, P., Fincato, G., Favoni, P., and Baccarani, M

Published
2005

243. Clinical relevance of immunophenotype in a retrospective comparative study of 297 peripheral T-cell lymphomas, unspecified, and 496 diffuse large B-cell lymphomas

Author

Morabito, F., Gallamini, A., Stelitano, C., Callea, V., Guglielmi, C., Neri, S., Lazzaro, A., Orsucci, L., Ilariucci, F., Sacchi, S., Vitolo, U., Federico, M., Intergruppo Italiano Linfomi, and Liberati, Anna Marina

Subjects
Clinical outcome, unspecified, Peripheral T-cell lymphoma, Diffuse large B-cell lymphoma, Prognosis, Immunophenotype, Peripheral T-cell lymphoma, unspecified
Published
2004

246. S.12.02 Absence of D-serine results in abnormal dopamine–glutamate dialogue in the prefrontal cortex

Author

Dallerac, G., primary, Tupin, F., additional, Morisot, N., additional, Levasseur, G., additional, Sacchi, S., additional, Fossat, P., additional, Rivet, J.M., additional, Oliet, S.H., additional, Coyle, J.T., additional, Pollegioni, L., additional, Snyder, S.H., additional, Contarino, A., additional, Millan, M.J., additional, and Mothet, J.P., additional

Published
2014
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248. Anagrelide in essential thrombocythemia: a retrospective analysis of 220 patients

Author

Gugliotta, L., Grossi, A., Mazzucconi, M. G., Bulgarelli, S., Gamberi, B., Imovilli, A., Ba, F., Lestri, Liso, V., Specchia, G., Scalzulli, P. R., Liberati, A. M., Bassetti, A., Angelucci, E., A, Tucci, Di, Iuliano, F., Gaidano, G., Conconi, A. R., Cacciola, E., Cacciola, Rossella Rosaria, Spriano, M., Prugnola, M., Tabilio, A., Balduini, C., Noris, P., Amato, B., Candoni, A., Balleari, E., Sacchi, S, Ambrosetti, A., Canotti, R., Giordano, M., Andriani, A., Sciorino, A., Ciocca, A., Vasino, Martinelli, V., Ciancia, R., Tringali, S., and Lauria, F.

Published
2003

250. Anagrelide in assential thronbocythemia: a retrospective study

Author

Gugliotta, L, Grossi, A, Mazzucconi, Mg, Bulgarelli, S, Beggi, C, Liso, V, Specchia, G, Coser, P, Amato, B, Angelucci, E, Di Tucci, A, Sciorino, A, Giustolisi, R, Cacciola, Emma, Cacciola, Rossella Rosaria, Iuliano, F, Giordano, M, Bosi, A, Balestri, F, Ghio, R, Balleari, E, Spriano, M, Sacchi, S, Marcheselli, R, Rotoli, B, Martinelli, V, Ciancia, R, Gaidano, G, Conconi, A, Rizzoli, V, Prugnola, M, Trincali, S, Balduini, C, Noris, P, Martelli, M, Tabilio, A, Liberati, Am, Germani, A, Andriani, A, Lauria, F, Gentili, S, Carella, Am, Scalzulli, Pr, Boccadoro, M, Ciocca Vasino, A, Fanin, R, Candoni, A, Pizzolo, G, Ambrosetti, A, and Canotti, R.

Published
2003

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