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1,260 results on '"Schnabel, Renate B."'

202. Reclassification, Thromboembolic, and Major Bleeding Outcomes Using Different Estimates of Renal Function in Anticoagulated Patients With Atrial Fibrillation: Insights From the PREFER-in-AF and PREFER-in-AF Prolongation Registries

Author

Rohla, Miklos, primary, Pecen, Ladislav, additional, Cemin, Roberto, additional, Patti, Giuseppe, additional, Siller-Matula, Jolanta M., additional, Schnabel, Renate B., additional, Huber, Kurt, additional, Kirchhof, Paulus, additional, and De Caterina, Raffaele, additional

Published
2021
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203. Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study

Author

Haeusler, Karl Georg, primary, Kirchhof, Paulus, additional, Kunze, Claudia, additional, Tütüncü, Serdar, additional, Fiessler, Cornelia, additional, Malsch, Carolin, additional, Olma, Manuel C, additional, Jawad-Ul-Qamar, Muhammad, additional, Krämer, Michael, additional, Wachter, Rolf, additional, Michalski, Dominik, additional, Kraft, Andrea, additional, Rizos, Timolaos, additional, Gröschel, Klaus, additional, Thomalla, Götz, additional, Nabavi, Darius G, additional, Röther, Joachim, additional, Laufs, Ulrich, additional, Veltkamp, Roland, additional, Heuschmann, Peter U, additional, Endres, Matthias, additional, Bauerle, Michael, additional, Besselmann, Michael, additional, Büttner, T, additional, Dem, Petra, additional, Diekmann, Jens, additional, Dietzel, Joanna, additional, Dziewas, Rainer, additional, Ehrlich, Sven, additional, Evens, Annette, additional, Gahn, Georg, additional, Günther, Albrecht, additional, Hamann, Gerhard F, additional, Hartmann, Andreas, additional, Harvey, Karen Louise, additional, Heidenreich, Fedor, additional, Helberg, T, additional, Hobohm, Carsten, additional, Hoffmann, F, additional, Hoffmann, Olaf, additional, Jungehulsing, Gerhard J, additional, Kampschulte, Eva-Maria, additional, Kraft, Peter, additional, Krogias, Christos, additional, Leinisch, Elke, additional, Maschke, Matthias, additional, Merkelbach, Stefan, additional, Muehler, Johannes, additional, Niehaus, Ludwig, additional, Nören, Gesa, additional, Oschmann, P, additional, Palm, Frederick, additional, Petzold, Gabor C, additional, Pfeiler, Larissa, additional, Pfeilschifter, Waltraud, additional, Prince, Marie, additional, Ringleb, Peter, additional, Rosenkranz, Michael, additional, Royl, Georg, additional, Schnabel, Renate B, additional, Schurig, Johannes, additional, Steinbrecher, A, additional, Stingele, Robert, additional, Tanislav, Christian, additional, Tyler, Louise, additional, and Urbanek, Christian, additional

Published
2021
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205. The Association of Periodontitis and Peripheral Arterial Occlusive Disease in a Prospective Population-Based Cross-Sectional Cohort Study

Author

Jacobi, Nicole, primary, Walther, Carolin, additional, Borof, Katrin, additional, Heydecke, Guido, additional, Seedorf, Udo, additional, Lamprecht, Ragna, additional, Beikler, Thomas, additional, Debus, Sebastian E., additional, Waldeyer, Christoph, additional, Blankenberg, Stefan, additional, Schnabel, Renate B., additional, Aarabi, Ghazal, additional, and Behrendt, Christian-Alexander, additional

Published
2021
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207. Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network

Author

Fluschnik, Nina, primary, Geelhoed, Bastiaan, additional, Becher, Peter Moritz, additional, Schrage, Benedikt, additional, Brunner, Fabian J., additional, Knappe, Dorit, additional, Bernhardt, Alexander M., additional, Blankenberg, Stefan, additional, Kobashigawa, Jon, additional, Reichenspurner, Hermann, additional, Schnabel, Renate B., additional, and Magnussen, Christina, additional

Published
2021
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208. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS) : the Task Force for the diagnosis and management of atrialfibrillation of the European Society of Cardiology (ESC) : developed with the special contribution of the European HeartRhythm Association (EHRA) of the ESC

Author

Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J., Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E., Fauchier, Laurent, Petersen, Steffen E., Piccini, Jonathan P., Popescu, Bogdan A., Pürerfellner, Helmut, Richter, Dimitrios J., Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B., Simpson, Iain A., Raatikainen, Pekka, Shlyakhto, Evgeny, Sinner, Moritz F., Steffel, Jan, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M., Windecker, Stephan, Baigent, Colin, Collet, Jean-Philippe, Dean, Veronica, Boveda, Serge, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Halvorsen, Sigrun, Lung, Bernard, Jüni, Peter, Petronio, Anna Sonia, Sousa Uva, Miguel, Delassi, Tahar, Sisakian, Hamayak S., Papiashvili, Giorgi, Chasnoits, Alexandr, De Pauw, Michel, Smajić, Elnur, Shalganov, Tchavdar, Avraamides, Panayiotis, Kautzner, Josef, Gerdes, Christian, Alaziz, Ahmad Abd, Kampus, Priit, Vassilikos, Vassilios P., Csanádi, Zoltán, Arnar, David O., Galvin, Joseph, Barsheshet, Alon, Caldarola, Pasquale, Rakisheva, Amina, Filippatos, Gerasimos, Bytyçi, Ibadete, Kerimkulova, Alina, Kalejs, Oskars, Njeim, Mario, Puodziukynas, Aras, Groben, Laurent, Sammut, Mark A., Grosu, Aurel, Boskovic, Aneta, Moustaghfir, Abdelhamid, Kalman, Jonathan M., de Groot, Natasja, Poposka, Lidija, Anfinsen, Ole-Gunnar, Mitkowski, Przemyslaw P., Cavaco, Diogo, Siliste, Calin, Mikhaylov, Evgeny N., Bertelli, Luca, Kojic, Dejan, Hatala, Robert, La Meir, Mark, Fras, Zlatko, Arribas, Fernando, Juhlin, Tord, Sticherling, Christian, Abid, Leila, Atar, Ilyas, Sychov, Oleg, Bates, Matthew G. D., Zakirov, Nodir U., Lane, Deirdre A., Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y. H., Pinto, Fausto J., Thomas, G. Neil, Valgimigli, Marco, Van Gelder, Isabelle C., Van Putte, Bart P., Watkins, Caroline L., Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A. John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J. G. M., Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Folliguet, Thierry, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A., Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S., Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V., Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F. E., and Repositório da Universidade de Lisboa

Subjects
Rate control, AF surgery, Guidelines, Upstream therapy, Recommendations, Left atrial appendage occlusion, Atrial fibrillation, Pulmonary vein isolation, Left atrial ablation, Antiarrhythmic drugs, Cardioversion, Stroke, Anticoagulation, Vitamin K antagonists, Screening, Non-vitamin K antagonist oral anticoagulants, Rhythm control, Catheter ablation, ABC pathway
Abstract

© 2020 European Society of Cardiology. All rights reserved., Atrial fibrillation (AF) poses significant burden to patients, physicians, and healthcare systems globally. Substantial research efforts and resources are being directed towards gaining detailed information about the mechanisms underlying AF, its natural course and effective treatments (see also the ESC Textbook of Cardiovascular Medicine: CardioMed) and new evidence is continuously generated and published. The complexity of AF requires a multifaceted, holistic, and multidisciplinary approach to the management of AF patients, with their active involvement in partnership with clinicians. Streamlining the care of patients with AF in daily clinical practice is a challenging but essential requirement for effective management of AF. In recent years, substantial progress has been made in the detection of AF and its management, and new evidence is timely integrated in this third edition of the ESC guidelines on AF. The 2016 ESC AF Guidelines introduced the concept of the five domains to facilitate an integrated structured approach to AF care and promote consistent, guideline-adherent management for all patients. The Atrial Fibrillation Better Care (ABC) approach in the 2020 ESC AF Guidelines is a continuum of this approach, with the goal to further improve the structured management of AF patients, promote patient values, and finally improve patient outcomes.

Published
2020

209. Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death

Author

Schrage, Benedikt, Geelhoed, Bastiaan, Niiranen, Teemu J., Gianfagna, Francesco, Vishram-Nielsen, Julie K. K., Costanzo, Simona, Söderberg, Stefan, Ojeda, Francisco M., Vartiainen, Erkki, Donati, Maria Benedetta, Magnussen, Christina, Di Castelnuovo, Augusto, Camen, Stephan, Kontto, Jukka, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Linneberg, Allan, Jorgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Tunstall-Pedoe, Hugh, Hughes, Maria, Iacoviello, Licia, Salomaa, Veikko, Schnabel, Renate B., Schrage, Benedikt, Geelhoed, Bastiaan, Niiranen, Teemu J., Gianfagna, Francesco, Vishram-Nielsen, Julie K. K., Costanzo, Simona, Söderberg, Stefan, Ojeda, Francisco M., Vartiainen, Erkki, Donati, Maria Benedetta, Magnussen, Christina, Di Castelnuovo, Augusto, Camen, Stephan, Kontto, Jukka, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Linneberg, Allan, Jorgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Tunstall-Pedoe, Hugh, Hughes, Maria, Iacoviello, Licia, Salomaa, Veikko, and Schnabel, Renate B.

Abstract

Background: Differences in risk factors for atrial fibrillation (AF) and heart failure (HF) are incompletely understood. Aim of this study was to understand whether risk factors and biomarkers show different associations with incident AF and HF and to investigate predictors of subsequent onset and mortality. Methods and Results: In N=58 693 individuals free of AF/HF from 5 population-based European cohorts, Cox regressions were used to find predictors for AF, HF, subsequent onset, and mortality. Differences between associations were estimated using bootstrapping. Median follow-up time was 13.8 years, with a mortality of 15.7%. AF and HF occurred in 5.0% and 5.4% of the participants, respectively, with 1.8% showing subsequent onset. Age, male sex, myocardial infarction, body mass index, and NT-proBNP (N-terminal pro-B-type natriuretic peptide) showed similar associations with both diseases. Antihypertensive medication and smoking were stronger predictors of HF than AF. Cholesterol, diabetes mellitus, and hsCRP (high-sensitivity C-reactive protein) were associated with HF, but not with AF. No variable was exclusively associated with AF. Population-attributable risks were higher for HF (75.6%) than for AF (30.9%). Age, male sex, body mass index, diabetes mellitus, and NT-proBNP were associated with subsequent onset, which was associated with the highest all-cause mortality risk. Conclusions: Common risk factors and biomarkers showed different associations with AF and HF, and explained a higher proportion of HF than AF risk. As the subsequent onset of both diseases was strongly associated with mortality, prevention needs to be rigorously addressed and remains challenging, as conventional risk factors explained o:nly 31% of AF risk.

Published
2020
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210. Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality

Author

Camen, Stephan, Ojeda, Francisco M., Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K., Costanzo, Simona, Söderberg, Stefan, Vartiainen, Erkki, Donati, Maria Benedetta, Løchen, Maja-Lisa, Pasterkamp, Gerard, Magnussen, Christina, Kee, Frank, Jousilahti, Pekka, Hughes, Maria, Kontto, Jukka, Mathiesen, Ellisiv B., Koenig, Wolfgang, Palosaari, Tarja, Blankenberg, Stefan, de Gaetano, Giovanni, Jorgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B., Camen, Stephan, Ojeda, Francisco M., Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K., Costanzo, Simona, Söderberg, Stefan, Vartiainen, Erkki, Donati, Maria Benedetta, Løchen, Maja-Lisa, Pasterkamp, Gerard, Magnussen, Christina, Kee, Frank, Jousilahti, Pekka, Hughes, Maria, Kontto, Jukka, Mathiesen, Ellisiv B., Koenig, Wolfgang, Palosaari, Tarja, Blankenberg, Stefan, de Gaetano, Giovanni, Jorgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, and Schnabel, Renate B.

Abstract

Aims Limited evidence is available on the temporal relationship between atrial fibrillation (AF) and ischaemic stroke and their impact on mortality in the community. We sought to understand the temporal relationship of AF and ischaemic stroke and to determine the sequence of disease onset in relation to mortality. Methods and results Across five prospective community cohorts of the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project we assessed baseline cardiovascular risk factors in 100 132 individuals, median age 46.1 (25th-75th percentile 35.8-57.5) years, 48.4% men. We followed them for incident ischaemic stroke and AF and determined the relation of subsequent disease diagnosis with overall mortality. Over a median follow-up of 16.1 years, N = 4555 individuals were diagnosed solely with AF, N = 2269 had an ischaemic stroke but no AF diagnosed, and N = 898 developed both, ischaemic stroke and AF. Temporal relationships showed a clustering of diagnosis of both diseases within the years around the diagnosis of the other disease. In multivariable-adjusted Cox regression analyses with time-dependent covariates subsequent diagnosis of AF after ischaemic stroke was associated with increased mortality [hazard ratio (HR) 4.05, 95% confidence interval (CI) 2.17-7.54; P < 0.001] which was also apparent when ischaemic stroke followed after the diagnosis of AF (HR 3.08, 95% CI 1.90-5.00; P < 0.001). Conclusion The temporal relations of ischaemic stroke and AF appear to be bidirectional. Ischaemic stroke may precede detection of AF by years. The subsequent diagnosis of both diseases significantly increases mortality risk. Future research needs to investigate the common underlying systemic disease processes.

Published
2020
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211. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS): 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

Author

Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, Watkins, Caroline L, Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, and Watkins, Caroline L

Published
2020

212. Cardiac Troponin I and Incident Stroke in European Cohorts : Insights From the BiomarCaRE Project

Author

Camen, Stephan, Palosaari, Tarja, Reinikainen, Jaakko, Spruenker, Ngoc Anh, Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K. K., Costanzo, Simona, Söderberg, Stefan, Palmieri, Luigi, Ferrario, Marco, Peters, Annette, Vartiainen, Erkki, Donati, Maria Benedetta, Donfrancesco, Chiara, Borchini, Rossana, Boerschel, Christin Susanna, Giampaoli, Simona, Di Castelnuovo, Augusto, Magnussen, Christina, Kee, Frank, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Tunstall-Pedoe, Hugh, Rospleszcz, Susanne, Jorgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B., Camen, Stephan, Palosaari, Tarja, Reinikainen, Jaakko, Spruenker, Ngoc Anh, Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K. K., Costanzo, Simona, Söderberg, Stefan, Palmieri, Luigi, Ferrario, Marco, Peters, Annette, Vartiainen, Erkki, Donati, Maria Benedetta, Donfrancesco, Chiara, Borchini, Rossana, Boerschel, Christin Susanna, Giampaoli, Simona, Di Castelnuovo, Augusto, Magnussen, Christina, Kee, Frank, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Tunstall-Pedoe, Hugh, Rospleszcz, Susanne, Jorgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, and Schnabel, Renate B.

Abstract

Background and Purpose: Stroke is a common cause of death and a leading cause of disability and morbidity. Stroke risk assessment remains a challenge, but circulating biomarkers may improve risk prediction. Controversial evidence is available on the predictive ability of troponin concentrations and the risk of stroke in the community. Furthermore, reports on the predictive value of troponin concentrations for different stroke subtypes are scarce. Methods: High-sensitivity cardiac troponin I (hsTnI) concentrations were assessed in 82 881 individuals (median age, 50.7 years; 49.7% men) free of stroke or myocardial infarction at baseline from 9 prospective European community cohorts. We used Cox proportional hazards regression to determine relative risks, followed by measures of discrimination and reclassification using 10-fold cross-validation to control for overoptimism. Follow-up was based upon linkage with national hospitalization registries and causes of death registries. Results: Over a median follow-up of 12.7 years, 3033 individuals were diagnosed with incident nonfatal or fatal stroke (n=1654 ischemic strokes, n=612 hemorrhagic strokes, and n=767 indeterminate strokes). In multivariable regression models, hsTnI concentrations were associated with overall stroke (hazard ratio per 1-SD increase, 1.15 [95% CI, 1.10-1.21]), ischemic stroke (hazard ratio, 1.14 [95% CI, 1.09-1.21]), and hemorrhagic stroke (hazard ratio, 1.10 [95% CI, 1.01-1.20]). Adding hsTnI concentrations to classical cardiovascular risk factors (C indices, 0.809, 0.840, and 0.736 for overall, ischemic, and hemorrhagic stroke, respectively) increased the C index significantly but modestly. In individuals with an intermediate 10-year risk (5%-20%), the net reclassification improvement for overall stroke was 0.038 (P=0.021). Conclusions: Elevated hsTnI concentrations are associated with an increased risk of incident stroke in the community, irrespective of stroke subtype. Adding hsTnI concentrations

Published
2020
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213. Rationale and Design of the Hamburg City Health Study

Author

Jagodzinski, Annika, Johansen, Christoffer, Koch-Gromus, Uwe, Aarabi, Ghazal, Adam, Gerhard, Anders, Sven, Augustin, Matthias, der Kellen, Ramona B., Beikler, Thomas, Behrendt, Christian Alexander, Betz, Christian S., Bokemeyer, Carsten, Borof, Katrin, Briken, Peer, Busch, Chia Jung, Büchel, Christian, Brassen, Stefanie, Debus, Eike S., Eggers, Larissa, Fiehler, Jens, Gallinat, Jürgen, Gellißen, Simone, Gerloff, Christian, Girdauskas, Evaldas, Gosau, Martin, Graefen, Markus, Härter, Martin, Harth, Volker, Heidemann, Christoph, Heydecke, Guido, Huber, Tobias B., Hussein, Yassin, Kampf, Marvin O., von dem Knesebeck, Olaf, Konnopka, Alexander, König, Hans Helmut, Kromer, Robert, Kubisch, Christian, Kühn, Simone, Loges, Sonja, Löwe, Bernd, Lund, Gunnar, Meyer, Christian, Nagel, Lina, Nienhaus, Albert, Pantel, Klaus, Petersen, Elina, Püschel, Klaus, Reichenspurner, Hermann, Sauter, Guido, Scherer, Martin, Scherschel, Katharina, Schiffner, Ulrich, Schnabel, Renate B., Schulz, Holger, Smeets, Ralf, Sokalskis, Vladislavs, Spitzer, Martin S., Terschüren, Claudia, Thederan, Imke, Thoma, Tom, Thomalla, Götz, Waschki, Benjamin, Wegscheider, Karl, Wenzel, Jan Per, Wiese, Susanne, Zyriax, Birgit Christiane, Zeller, Tanja, Blankenberg, Stefan, Jagodzinski, Annika, Johansen, Christoffer, Koch-Gromus, Uwe, Aarabi, Ghazal, Adam, Gerhard, Anders, Sven, Augustin, Matthias, der Kellen, Ramona B., Beikler, Thomas, Behrendt, Christian Alexander, Betz, Christian S., Bokemeyer, Carsten, Borof, Katrin, Briken, Peer, Busch, Chia Jung, Büchel, Christian, Brassen, Stefanie, Debus, Eike S., Eggers, Larissa, Fiehler, Jens, Gallinat, Jürgen, Gellißen, Simone, Gerloff, Christian, Girdauskas, Evaldas, Gosau, Martin, Graefen, Markus, Härter, Martin, Harth, Volker, Heidemann, Christoph, Heydecke, Guido, Huber, Tobias B., Hussein, Yassin, Kampf, Marvin O., von dem Knesebeck, Olaf, Konnopka, Alexander, König, Hans Helmut, Kromer, Robert, Kubisch, Christian, Kühn, Simone, Loges, Sonja, Löwe, Bernd, Lund, Gunnar, Meyer, Christian, Nagel, Lina, Nienhaus, Albert, Pantel, Klaus, Petersen, Elina, Püschel, Klaus, Reichenspurner, Hermann, Sauter, Guido, Scherer, Martin, Scherschel, Katharina, Schiffner, Ulrich, Schnabel, Renate B., Schulz, Holger, Smeets, Ralf, Sokalskis, Vladislavs, Spitzer, Martin S., Terschüren, Claudia, Thederan, Imke, Thoma, Tom, Thomalla, Götz, Waschki, Benjamin, Wegscheider, Karl, Wenzel, Jan Per, Wiese, Susanne, Zyriax, Birgit Christiane, Zeller, Tanja, and Blankenberg, Stefan

Abstract

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale lo

Published
2020

214. Cardiac Troponin I and Incident Stroke in European Cohorts:Insights From the BiomarCaRE Project

Author

Camen, Stephan, Palosaari, Tarja, Reinikainen, Jaakko, Sprünker, Ngoc Anh, Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K.K., Costanzo, Simona, Söderberg, Stefan, Palmieri, Luigi, Ferrario, Marco, Peters, Annette, Vartiainen, Erkki, Donati, Maria Benedetta, Donfrancesco, Chiara, Borchini, Rossana, Börschel, Christin Susanna, Giampaoli, Simona, Di Castelnuovo, Augusto, Magnussen, Christina, Kee, Frank, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Tunstall-Pedoe, Hugh, Rospleszcz, Susanne, Jørgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B., Camen, Stephan, Palosaari, Tarja, Reinikainen, Jaakko, Sprünker, Ngoc Anh, Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K.K., Costanzo, Simona, Söderberg, Stefan, Palmieri, Luigi, Ferrario, Marco, Peters, Annette, Vartiainen, Erkki, Donati, Maria Benedetta, Donfrancesco, Chiara, Borchini, Rossana, Börschel, Christin Susanna, Giampaoli, Simona, Di Castelnuovo, Augusto, Magnussen, Christina, Kee, Frank, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Tunstall-Pedoe, Hugh, Rospleszcz, Susanne, Jørgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, and Schnabel, Renate B.

Abstract

BACKGROUND AND PURPOSE: Stroke is a common cause of death and a leading cause of disability and morbidity. Stroke risk assessment remains a challenge, but circulating biomarkers may improve risk prediction. Controversial evidence is available on the predictive ability of troponin concentrations and the risk of stroke in the community. Furthermore, reports on the predictive value of troponin concentrations for different stroke subtypes are scarce. METHODS: High-sensitivity cardiac troponin I (hsTnI) concentrations were assessed in 82 881 individuals (median age, 50.7 years; 49.7% men) free of stroke or myocardial infarction at baseline from 9 prospective European community cohorts. We used Cox proportional hazards regression to determine relative risks, followed by measures of discrimination and reclassification using 10-fold cross-validation to control for overoptimism. Follow-up was based upon linkage with national hospitalization registries and causes of death registries. RESULTS: Over a median follow-up of 12.7 years, 3033 individuals were diagnosed with incident nonfatal or fatal stroke (n=1654 ischemic strokes, n=612 hemorrhagic strokes, and n=767 indeterminate strokes). In multivariable regression models, hsTnI concentrations were associated with overall stroke (hazard ratio per 1-SD increase, 1.15 [95% CI, 1.10-1.21]), ischemic stroke (hazard ratio, 1.14 [95% CI, 1.09-1.21]), and hemorrhagic stroke (hazard ratio, 1.10 [95% CI, 1.01-1.20]). Adding hsTnI concentrations to classical cardiovascular risk factors (C indices, 0.809, 0.840, and 0.736 for overall, ischemic, and hemorrhagic stroke, respectively) increased the C index significantly but modestly. In individuals with an intermediate 10-year risk (5%-20%), the net reclassification improvement for overall stroke was 0.038 (P=0.021). CONCLUSIONS: Elevated hsTnI concentrations are associated with an increased risk of incident stroke in the community, irrespective of stroke subtype. Adding hsTnI concentrati

Published
2020

215. Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality

Author

CDL Pre-analyse Centraal, CDL Onderzoek Pasterkamp, Circulatory Health, dLAB Afdelingen, Camen, Stephan, Ojeda, Francisco M., Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K., Costanzo, Simona, Söderberg, Stefan, Vartiainen, Erkki, Donati, Maria Benedetta, Løchen, Maja Lisa, Pasterkamp, Gerard, Magnussen, Christina, Kee, Frank, Jousilahti, Pekka, Hughes, Maria, Kontto, Jukka, Mathiesen, Ellisiv B., Koenig, Wolfgang, Palosaari, Tarja, Blankenberg, Stefan, De Gaetano, Giovanni, Jørgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B., CDL Pre-analyse Centraal, CDL Onderzoek Pasterkamp, Circulatory Health, dLAB Afdelingen, Camen, Stephan, Ojeda, Francisco M., Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K., Costanzo, Simona, Söderberg, Stefan, Vartiainen, Erkki, Donati, Maria Benedetta, Løchen, Maja Lisa, Pasterkamp, Gerard, Magnussen, Christina, Kee, Frank, Jousilahti, Pekka, Hughes, Maria, Kontto, Jukka, Mathiesen, Ellisiv B., Koenig, Wolfgang, Palosaari, Tarja, Blankenberg, Stefan, De Gaetano, Giovanni, Jørgensen, Torben, Zeller, Tanja, Kuulasmaa, Kari, Linneberg, Allan, Salomaa, Veikko, Iacoviello, Licia, and Schnabel, Renate B.

Published
2020

216. Neues beim Schlaganfall – Teil 1: Akuttherapie

Author

Diener, Hans-Christoph, additional, Fiehler, Jens, additional, Häusler, Karl Georg, additional, Kuramatsu, Joji B., additional, Pfeilschifter, Waltraud, additional, Purrucker, Jan Christoph, additional, Schnabel, Renate B., additional, Sembill, Jochen A., additional, Veltkamp, Roland, additional, and Weimar, Christian, additional

Published
2021
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218. Clinical Factors Associated with Atrial Fibrillation Detection on Single-Time Point Screening Using a Hand-Held Single-Lead ECG Device

Author

Boriani, Giuseppe, primary, Palmisano, Pietro, additional, Malavasi, Vincenzo Livio, additional, Fantecchi, Elisa, additional, Vitolo, Marco, additional, Bonini, Niccolo’, additional, Imberti, Jacopo F., additional, Valenti, Anna Chiara, additional, Schnabel, Renate B., additional, and Freedman, Ben, additional

Published
2021
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219. Heart and brain interactions

Author

Schnabel, Renate B., primary, Hasenfuß, Gert, additional, Buchmann, Sylvia, additional, Kahl, Kai G., additional, Aeschbacher, Stefanie, additional, Osswald, Stefan, additional, and Angermann, Christiane E., additional

Published
2021
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220. Research Priorities in Atrial Fibrillation Screening

Author

Benjamin, Emelia J., primary, Go, Alan S., additional, Desvigne-Nickens, Patrice, additional, Anderson, Christopher D., additional, Casadei, Barbara, additional, Chen, Lin Y., additional, Crijns, Harry J.G.M., additional, Freedman, Ben, additional, Hills, Mellanie True, additional, Healey, Jeff S., additional, Kamel, Hooman, additional, Kim, Dong-Yun, additional, Link, Mark S., additional, Lopes, Renato D., additional, Lubitz, Steven A., additional, McManus, David D., additional, Noseworthy, Peter A., additional, Perez, Marco V., additional, Piccini, Jonathan P., additional, Schnabel, Renate B., additional, Singer, Daniel E., additional, Tieleman, Robert G., additional, Turakhia, Mintu P., additional, Van Gelder, Isabelle C., additional, Cooper, Lawton S., additional, and Al-Khatib, Sana M., additional

Published
2021
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221. Risk prediction of atrial fibrillation in the community combining biomarkers and genetics

Author

Börschel, Christin S, primary, Ohlrogge, Amelie H, additional, Geelhoed, Bastiaan, additional, Niiranen, Teemu, additional, Havulinna, Aki S, additional, Palosaari, Tarja, additional, Jousilahti, Pekka, additional, Rienstra, Michiel, additional, van der Harst, Pim, additional, Blankenberg, Stefan, additional, Zeller, Tanja, additional, Salomaa, Veikko, additional, and Schnabel, Renate B, additional

Published
2021
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222. Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Author

Csengeri, Dora, primary, Sprünker, Ngoc-Anh, additional, Di Castelnuovo, Augusto, additional, Niiranen, Teemu, additional, Vishram-Nielsen, Julie Kk, additional, Costanzo, Simona, additional, Söderberg, Stefan, additional, Jensen, Steen M, additional, Vartiainen, Erkki, additional, Donati, Maria Benedetta, additional, Magnussen, Christina, additional, Camen, Stephan, additional, Gianfagna, Francesco, additional, Løchen, Maja-Lisa, additional, Kee, Frank, additional, Kontto, Jukka, additional, Mathiesen, Ellisiv B, additional, Koenig, Wolfgang, additional, Blankenberg, Stefan, additional, de Gaetano, Giovanni, additional, Jørgensen, Torben, additional, Kuulasmaa, Kari, additional, Zeller, Tanja, additional, Salomaa, Veikko, additional, Iacoviello, Licia, additional, and Schnabel, Renate B, additional

Published
2021
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225. World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update

Author

Freedman, Ben, primary, Hindricks, Gerhard, additional, Banerjee, Amitava, additional, Baranchuk, Adrian, additional, Ching, Chi Keong, additional, Du, Xin, additional, Fitzsimons, Donna, additional, Healey, Jeff S., additional, Ikeda, Takanori, additional, Lobban, Trudie C. A., additional, Mbakwem, Amam, additional, Narasimhan, Calambur, additional, Neubeck, Lis, additional, Noseworthy, Peter, additional, Philbin, Daniel M., additional, Pinto, Fausto J., additional, Rwebembera, Joselyn, additional, Schnabel, Renate B., additional, Svendsen, Jesper Hastrup, additional, Aguinaga, Luis, additional, Arbelo, Elena, additional, Böhm, Michael, additional, Farhan, Hasan Ali, additional, Hobbs, F. D. Richard, additional, Martínez-Rubio, Antoni, additional, Militello, Claudio, additional, Naik, Nitish, additional, Noubiap, Jean Jacques, additional, Perel, Pablo, additional, Piñeiro, Daniel José, additional, Ribeiro, Antonio Luiz, additional, and Stepinska, Janina, additional

Published
2021
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227. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia

Author

Reiner, Alexander P., Hartiala, Jaana, Zeller, Tanja, Bis, Joshua C., Dupuis, Josée, Fornage, Myriam, Baumert, Jens, Kleber, Marcus E., Wild, Philipp S., Baldus, Stephan, Bielinski, Suzette J., Fontes, João D., Illig, Thomas, Keating, Brendan J., Lange, Leslie A., Ojeda, Francisco, Müller-Nurasyid, Martina, Munzel, Thomas F., Psaty, Bruce M., Rice, Kenneth, Rotter, Jerome I., Schnabel, Renate B., Tang, W.H. Wilson, Thorand, Barbara, Erdmann, Jeanette, Consortium, CARDIoGRAM, Jacobs, David R., Jr, Wilson, James G., Koenig, Wolfgang, Tracy, Russell P., Blankenberg, Stefan, März, Winfried, Gross, Myron D., Benjamin, Emelia J., Hazen, Stanley L., and Allayee, Hooman

Published
2013
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231. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Author

Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline L, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Cardiovascular Centre (CVC), Surgical clinical sciences, and Cardiac Surgery

Subjects
left atrial ablation, left atrial appendage occlusion, AF surgery, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Management of atrial fibrillation, 030204 cardiovascular system & hematology, Cardioversion, VITAMIN-K ANTAGONIST, surgery, chemistry.chemical_compound, 0302 clinical medicine, cardioversion, Edoxaban, QUALITY-OF-LIFE, antiarrhythmic drugs, OBSTRUCTIVE SLEEP-APNEA, catheter ablation, RADIOFREQUENCY CATHETER ABLATION, Medicine, atrial fibrillation, 030212 general & internal medicine, anticoagulation, reproductive and urinary physiology, ComputingMilieux_MISCELLANEOUS, pulmonary vein isolation, 0303 health sciences, rhythm control, EACTS, HEART RHYTHM SOCIETY, recommendations, Atrial fibrillation, General Medicine, non-Vitamin K antagonist oral anticoagulants, Vitamin K antagonist, PULMONARY-VEIN ISOLATION, stroke, 3. Good health, 2020 ESC Guidelines, Dronedarone, vitamin K antagonists, Cardiothoracic surgery, Cardio-Thoracic Surgery, embryonic structures, DIRECT ORAL ANTICOAGULANTS, cardiovascular system, Cardiology, Dose reduction, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, medicine.drug, Quinidine, medicine.medical_specialty, medicine.drug_class, non-vitamin K antagonist oral anticoagulants, PERCUTANEOUS CORONARY INTERVENTION, Renal function, macromolecular substances, ABC pathway, Guidelines, rate control, screening, upstream therapy, Vitamin K antagonists, B700, 03 medical and health sciences, Internal medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, 030304 developmental biology, urogenital system, business.industry, medicine.disease, TRANSIENT ISCHEMIC ATTACK, ANTIARRHYTHMIC-DRUG-THERAPY, chemistry, 030228 respiratory system, Concomitant, RC666-701, business
Abstract

Supplementary Table 9, column 'Edoxaban', row 'eGFR category', '95 mL/min' (page 15). The cell should be coloured green instead of yellow. It should also read "60 mg"instead of "60 mg (use with caution in 'supranormal' renal function)."In the above-indicated cell, a footnote has also been added to state: "Edoxaban should be used in patients with high creatinine clearance only after a careful evaluation of the individual thromboembolic and bleeding risk."Supplementary Table 9, column 'Edoxaban', row 'Dose reduction in selected patients' (page 16). The cell should read "Edoxaban 60 mg reduced to 30 mg once daily if any of the following: creatinine clearance 15-50 mL/min, body weight

Published
2021
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233. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

Author

Grallert, Harald, Dupuis, Josée, Bis, Joshua C., Dehghan, Abbas, Barbalic, Maja, Baumert, Jens, Lu, Chen, Smith, Nicholas L., Uitterlinden, André G., Roberts, Robert, Khuseyinova, Natalie, Schnabel, Renate B., Rice, Kenneth M., Rivadeneira, Fernando, Hoogeveen, Ron C., Fontes, João Daniel, Meisinger, Christa, Keaney, John F., Jr., Lemaitre, Rozenn, Aulchenko, Yurii S., Vasan, Ramachandran S., Ellis, Stephen, Hazen, Stanley L., van Duijn, Cornelia M., Nelson, Jeanenne J., März, Winfried, Schunkert, Heribert, McPherson, Ruth M., Stirnadel-Farrant, Heide A., Psaty, Bruce M., Gieger, Christian, Siscovick, David, Hofman, Albert, Illig, Thomas, Cushman, Mary, Yamamoto, Jennifer F., Rotter, Jerome I., Larson, Martin G., Stewart, Alexandre F.R., Boerwinkle, Eric, Witteman, Jacqueline C.M., Tracy, Russell P., Koenig, Wolfgang, Benjamin, Emelia J., and Ballantyne, Christie M.

Published
2012
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235. Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference

Author

Fabritz, Larissa, primary, Crijns, Harry J G M, additional, Guasch, Eduard, additional, Goette, Andreas, additional, Häusler, Karl Georg, additional, Kotecha, Dipak, additional, Lewalter, Thorsten, additional, Meyer, Christian, additional, Potpara, Tatjana S, additional, Rienstra, Michiel, additional, Schnabel, Renate B, additional, Willems, Stephan, additional, Breithardt, Guenter, additional, Camm, A John, additional, Chan, Anthony, additional, Chua, Winnie, additional, de Melis, Mirko, additional, Dimopoulou, Christina, additional, Dobrev, Dobromir, additional, Easter, Christina, additional, Eckardt, Lars, additional, Haase, Doreen, additional, Hatem, Stephane, additional, Healey, Jeff S, additional, Heijman, Jordi, additional, Hohnloser, Stefan H, additional, Huebner, Thomas, additional, Ilyas, Bushra Saeed, additional, Isaacs, Aaron, additional, Kutschka, Ingo, additional, Leclercq, Christophe, additional, Lip, Gregory Y H, additional, Marinelli, Elena Andreassi, additional, Merino, Jose L, additional, Mont, Lluís, additional, Nabauer, Michael, additional, Oldgren, Jonas, additional, Pürerfellner, Helmut, additional, Ravens, Ursula, additional, Savelieva, Irina, additional, Sinner, Moritz F, additional, Sitch, Alice, additional, Smolnik, Rüdiger, additional, Steffel, Jan, additional, Stein, Kenneth, additional, Stoll, Monika, additional, Svennberg, Emma, additional, Thomas, Dierk, additional, Van Gelder, Isabelle C, additional, Vardar, Burcu, additional, Wakili, Reza, additional, Wieloch, Mattias, additional, Zeemering, Stef, additional, Ziegler, Paul D, additional, Heidbuchel, Hein, additional, Hindricks, Gerhard, additional, Schotten, Ulrich, additional, and Kirchhof, Paulus, additional

Published
2020
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238. No impact of sex and age on beta‐adrenoceptor‐mediated inotropy in human right atrial trabeculae

Author

Pecha, Simon, primary, Geelhoed, Bastiaan, additional, Kempe, Romy, additional, Berk, Emanuel, additional, Engel, Andreas, additional, Girdauskas, Evaldas, additional, Reichenspurner, Hermann, additional, Ravens, Ursula, additional, Kaumann, Alberto, additional, Eschenhagen, Thomas, additional, Schnabel, Renate B., additional, and Christ, Torsten, additional

Published
2020
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240. Antithrombotic management and outcomes of patients with atrial fibrillation treated with NOACs early at the time of market introduction: Main results from the PREFER in AF Prolongation Registry

Author

Renda, Giulia, primary, Pecen, Ladislav, additional, Patti, Giuseppe, additional, Ricci, Fabrizio, additional, Kotecha, Dipak, additional, Siller-Matula, Jolanta M., additional, Schnabel, Renate B., additional, Wachter, Rolf, additional, Sellal, Jean-Marc, additional, Rohla, Miklos, additional, Lucerna, Markus, additional, Huber, Kurt, additional, Verheugt, Freek W. A., additional, Zamorano, Jose Luis, additional, Brüggenjürgen, Bernd, additional, Darius, Harald, additional, Duytschaever, Mattias, additional, Le Heuzey, Jean-Yves, additional, Schilling, Richard J., additional, Kirchhof, Paulus, additional, and De Caterina, Raffaele, additional

Published
2020
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241. Assessment of causality of natriuretic peptides and atrial fibrillation and heart failure: a Mendelian randomization study in the FINRISK cohort

Author

Geelhoed, Bastiaan, primary, Börschel, Christin S, additional, Niiranen, Teemu, additional, Palosaari, Tarja, additional, Havulinna, Aki S, additional, Fouodo, Césaire J K, additional, Scheinhardt, Markus O, additional, Blankenberg, Stefan, additional, Jousilahti, Pekka, additional, Kuulasmaa, Kari, additional, Zeller, Tanja, additional, Salomaa, Veikko, additional, and Schnabel, Renate B, additional

Published
2020
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244. Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death

Author

Schrage, Benedikt, primary, Geelhoed, Bastiaan, additional, Niiranen, Teemu J., additional, Gianfagna, Francesco, additional, Vishram‐Nielsen, Julie K. K., additional, Costanzo, Simona, additional, Söderberg, Stefan, additional, Ojeda, Francisco M., additional, Vartiainen, Erkki, additional, Donati, Maria Benedetta, additional, Magnussen, Christina, additional, Di Castelnuovo, Augusto, additional, Camen, Stephan, additional, Kontto, Jukka, additional, Koenig, Wolfgang, additional, Blankenberg, Stefan, additional, de Gaetano, Giovanni, additional, Linneberg, Allan, additional, Jørgensen, Torben, additional, Zeller, Tanja, additional, Kuulasmaa, Kari, additional, Tunstall‐Pedoe, Hugh, additional, Hughes, Maria, additional, Iacoviello, Licia, additional, Salomaa, Veikko, additional, and Schnabel, Renate B., additional

Published
2020
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245. Cardio‐Renal Biomarker Soluble Urokinase‐Type Plasminogen Activator Receptor Is Associated With Cardiovascular Death and Myocardial Infarction in Patients With Coronary Artery Disease Independent of Troponin, C‐Reactive Protein, and Renal Function

Author

Nikorowitsch, Julius, primary, Borchardt, Tim, additional, Appelbaum, Sebastian, additional, Ojeda, Francisco, additional, Lackner, Karl J., additional, Schnabel, Renate B., additional, Blankenberg, Stefan, additional, Zeller, Tanja, additional, and Karakas, Mahir, additional

Published
2020
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246. White Blood Cells and Blood Pressure

Author

Siedlinski, Mateusz, primary, Jozefczuk, Ewelina, additional, Xu, Xiaoguang, additional, Teumer, Alexander, additional, Evangelou, Evangelos, additional, Schnabel, Renate B., additional, Welsh, Paul, additional, Maffia, Pasquale, additional, Erdmann, Jeanette, additional, Tomaszewski, Maciej, additional, Caulfield, Mark J., additional, Sattar, Naveed, additional, Holmes, Michael V., additional, and Guzik, Tomasz J., additional

Published
2020
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247. Tissue-specific multiOMICs analysis of atrial fibrillation

Author

Assum, Ines, primary, Krause, Julia, additional, Scheinhardt, Markus O., additional, Müller, Christian, additional, Hammer, Elke, additional, Börschel, Christin S., additional, Völker, Uwe, additional, Conradi, Lenard, additional, Geelhoed, Bastiaan, additional, Zeller, Tanja, additional, Schnabel, Renate B., additional, and Heinig, Matthias, additional

Published
2020
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250. Multiple marker approach to risk stratification in patients with stable coronary artery disease

Author

Schnabel, Renate B., Schulz, Andreas, Messow, C. Martina, Lubos, Edith, Wild, Philipp S., Zeller, Tanja, Sinning, Christoph R., Rupprecht, Hans J., Bickel, Christoph, Peetz, Dirk, Cambien, François, Kempf, Tibor, Wollert, Kai C., Benjamin, Emelia J., Lackner, Karl J., Münzel, Thomas F., Tiret, Laurence, Vasan, Ramachandran S., and Blankenberg, Stefan

Published
2010
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