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Your search keyword '"Shimizu, Norio"' showing total 754 results
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754 results on '"Shimizu, Norio"'

210. Ex vivoexpanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin

Author

Miyagawa, Yoshitaka, primary, Kiyokawa, Nobutaka, additional, Ochiai, Nakaba, additional, Imadome, Ken-Ichi, additional, Horiuchi, Yasuomi, additional, Onda, Keiko, additional, Yajima, Misako, additional, Nakamura, Hiroyuki, additional, Katagiri, Yohko U., additional, Okita, Hajime, additional, Morio, Tomohiro, additional, Shimizu, Norio, additional, Fujimoto, Junichiro, additional, and Fujiwara, Shigeyoshi, additional

Published
2009
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215. Partial monosomy 10q and partial trisomy 9q with anal atresia due to maternal translocation: t(9;10)(q32;q26)

Author

Tsukuda, Toshinori, primary, Nagata, Ikuo, additional, Sawada, Hiroshi, additional, Murakami, Jun, additional, Hanaki, Keiichi, additional, Urashima, Hirofumi, additional, Kaneda, Tomoharu, additional, Shimizu, Norio, additional, Kaibara, Nobuaki, additional, Kodama, Nagao, additional, Ohzeki, Takehiko, additional, and Shiraki, Kazuo, additional

Published
2008
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216. The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-κB

Author

Nakamura, Hiroyuki, primary, Ishii, Chihiro, additional, Suehiro, Masakazu, additional, Iguchi, Akifumi, additional, Kuroda, Kazumichi, additional, Shimizu, Kazufumi, additional, Shimizu, Norio, additional, Imadome, Ken-Ichi, additional, Yajima, Misako, additional, and Fujiwara, Shigeyoshi, additional

Published
2008
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217. Humanized NOD/SCID/IL2Rγ null Mice Transplanted with Hematopoietic Stem Cells under Nonmyeloablative Conditions Show Prolonged Life Spans and Allow Detailed Analysis of Human Immunodeficiency Virus Type 1 Pathogenesis

Author

Watanabe, Satoru, primary, Ohta, Shinrai, additional, Yajima, Misako, additional, Terashima, Kazuo, additional, Ito, Mamoru, additional, Mugishima, Hideo, additional, Fujiwara, Shigeyoshi, additional, Shimizu, Kazufumi, additional, Honda, Mitsuo, additional, Shimizu, Norio, additional, and Yamamoto, Naoki, additional

Published
2007
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221. Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

Author

Watanabe, Satoru, primary, Terashima, Kazuo, additional, Ohta, Shinrai, additional, Horibata, Shigeo, additional, Yajima, Misako, additional, Shiozawa, Yoko, additional, Dewan, M. Zahidunnabi, additional, Yu, Zhong, additional, Ito, Mamoru, additional, Morio, Tomohiro, additional, Shimizu, Norio, additional, Honda, Mitsuo, additional, and Yamamoto, Naoki, additional

Published
2006
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222. Expression of Interleukin-9 in Nasal Natural Killer/T-Cell Lymphoma Cell Lines and Patients

Author

Nagato, Toshihiro, primary, Kobayashi, Hiroya, additional, Kishibe, Kan, additional, Takahara, Miki, additional, Ogino, Takeshi, additional, Ishii, Hideyuki, additional, Oikawa, Kensuke, additional, Aoki, Naoko, additional, Sato, Keisuke, additional, Kimura, Shoji, additional, Shimizu, Norio, additional, Tateno, Masatoshi, additional, and Harabuchi, Yasuaki, additional

Published
2005
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227. Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma

Author

Shen, Lijun, primary, Liang, Anthony C. T., additional, Lu, Liwei, additional, Au, Wing Y., additional, Wong, Kai-Yau, additional, Tin, Pui-Chi, additional, Chan, Kwok-Wah, additional, Ko, King-Hung, additional, Chen, Yun-Wen, additional, Beh, Swan-Lip, additional, Shimizu, Norio, additional, Tsuchiyama, Junjiro, additional, Tang, Johnny C. O., additional, Kwong, Yok-Lam, additional, Liang, Raymond H. S., additional, and Srivastava, Gopesh, additional

Published
2003
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229. Preferential Expansion of Vγ9-JγP/Vδ2-Jδ3 γδ T Cells in Nasal T-Cell Lymphoma and Chronic Active Epstein-Barr Virus Infection

Author

Oyoshi, Michiko K., primary, Nagata, Hiroshi, additional, Kimura, Nobuhiro, additional, Zhang, Yu, additional, Demachi, Ayako, additional, Hara, Toshiro, additional, Kanegane, Hirokazu, additional, Matsuo, Yoshinobu, additional, Yamaguchi, Tomohiro, additional, Morio, Tomohiro, additional, Hirano, Atsuyoshi, additional, Shimizu, Norio, additional, and Yamamoto, Kohtaro, additional

Published
2003
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242. Molecular and Virological Evidence of Viral Activation From Chromosomally Integrated Human Herpesvirus 6A in a Patient With X-Linked Severe Combined Immunodeficiency.

Author

Endo, Akifumi, Watanabe, Ken, Ohye, Tamae, Suzuki, Kyoko, Matsubara, Tomoyo, Shimizu, Norio, Kurahashi, Hiroki, Yoshikawa, Tetsushi, Katano, Harutaka, Inoue, Naoki, Imai, Kohsuke, Takagi, Masatoshi, Morio, Tomohiro, and Mizutani, Shuki

Subjects
HUMAN herpesvirus-6, SEVERE combined immunodeficiency, X chromosome, THROMBOTIC thrombocytopenic purpura, VIROLOGY
Abstract

It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6. [ABSTRACT FROM PUBLISHER]

Published
2014
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243. Current research on chronic active Epstein- Barr virus infection in Japan.

Author

Fujiwara, Shigeyoshi, Kimura, Hiroshi, Imadome, Ken‐ichi, Arai, Ayako, Kodama, Eiichi, Morio, Tomohiro, Shimizu, Norio, and Wakiguchi, Hiroshi

Subjects
CHRONIC diseases, FLOW cytometry, EPSTEIN-Barr virus diseases, IN situ hybridization, MEDICAL research, DISEASE relapse, DISEASE complications, SYMPTOMS, PROGNOSIS, DIAGNOSIS
Abstract

Epstein- Barr virus ( EBV) infection is usually asymptomatic and persists lifelong. Although EBV-infected B cells have the potential for unlimited proliferation, they are effectively removed by the virus-specific cytotoxic T cells, and EBV-associated lymphoproliferative disease develops only in immunocompromised hosts. Rarely, however, individuals without apparent immunodeficiency develop chronic EBV infection with persistent infectious mononucleosis-like symptoms. These patients have high EBV-DNA load in the peripheral blood and systemic clonal expansion of EBV-infected T cells or natural killer ( NK) cells. Their prognosis is poor with life-threatening complications including hemophagocytic lymphohistiocytosis, organ failure, and malignant lymphomas. The term 'chronic active EBV infection' ( CAEBV) is now generally used for this disease. The geographical distribution of CAEBV is markedly uneven and most cases have been reported from Japan and other East Asian countries. Here we summarize the current understanding of CAEBV and describe the recent progress of CAEBV research in Japan. [ABSTRACT FROM AUTHOR]

Published
2014
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244. Detection of Herpes Viruses by Multiplex and Real-Time Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of Patients with Acute Lung Injury or Acute Respiratory Distress Syndrome.

Author

Tachikawa, Ryo, Tomii, Keisuke, Seo, Ryutaro, Nagata, Kazuma, Otsuka, Kyoko, Nakagawa, Atsushi, Otsuka, Kojiro, Hashimoto, Hisako, Watanabe, Ken, and Shimizu, Norio

Subjects
BRONCHOALVEOLAR lavage, CHI-squared test, FISHER exact test, HERPESVIRUSES, LUNG injuries, POLYMERASE chain reaction, ADULT respiratory distress syndrome, ACUTE diseases
Abstract

Background: Human herpes viruses (HHVs) are important pathogens in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Rapid and efficient diagnostic tools are needed to detect HHVs in the lung in ALI/ARDS patients. Objectives: This study aimed to evaluate the usefulness of multiplex and real-time polymerase chain reaction (PCR) analysis of bronchoalveolar lavage fluid (BALF) for detecting HHV reactivation in ALI/ARDS patients. Methods: Between August 2008 and July 2012, eighty-seven BALF samples were obtained from ALI/ARDS patients with unknown etiology and analyzed for HHVs. The types of HHVs in the BALF samples were determined using qualitative multiplex PCR followed by quantitative real-time PCR. Results: Multiplex PCR identified herpes simplex virus type 1 (HSV-1) (n = 11), Epstein-Barr virus (EBV) (n = 16), cytomegalovirus (CMV) (n = 21), HHV type 6 (HHV-6) (n = 2), and HHV-7 (n = 1) genomic DNA in 35 (40%) of the BALF samples, including 14 (16%) samples containing 2 or 3 HHV types. CMV and EBV reactivation was rare in immunocompetent patients, whereas reactivation of HSV-1 was predominantly observed in intubated patients regardless of their immune status. Overall, HHVs were almost exclusively found in patients with immunosuppression or endotracheal intubation. Real-time PCR detected 0.95-1.59 × 106 copies of viral DNA/μg human genome DNA, and HSV-1 (n = 4), CMV (n = 9), and HHV-6 (n = 1) were identified as potentially pathogenic agents. Conclusions: The implementation of multiplex and real-time PCR of BALF was feasible in ALI/ARDS patients, which allowed efficient detection and quantification of HHV DNA. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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