1,412 results on '"Socié G"'
Search Results
202. Polymorphism of the complement receptor 1 gene correlates with hematological response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria
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Rondelli T, Peffault de Latour R, Sica M, Peruzzi B, Ricci P, Barcellini W, Iori AP, Boschetti C, Valle V, Frémeaux Bacchi V, De Angioletti M, Socié G, Luzzatto L, Notaro R., RISITANO, ANTONIO MARIA, Rondelli, T, Risitano, ANTONIO MARIA, Peffault de Latour, R, Sica, M, Peruzzi, B, Ricci, P, Barcellini, W, Iori, Ap, Boschetti, C, Valle, V, Frémeaux Bacchi, V, De Angioletti, M, Socié, G, Luzzatto, L, and Notaro, R.
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- 2014
203. Meningioma in long-term survivors after allogeneic bone marrow transplantation
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Meignin, V, Gluckman, E, Gambaraelli, D, Devergie, A, Ramee, MP, Janin, A, and Socié, G
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- 1998
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204. Could aplastic anaemia be considered a pre-pre-leukaemic disorder?
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Socié G
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Anemia ,Population ,Risk Factors ,hemic and lymphatic diseases ,medicine ,Humans ,Cumulative incidence ,education ,education.field_of_study ,Leukemia ,business.industry ,Incidence (epidemiology) ,Anemia, Aplastic ,Hematology ,General Medicine ,Aplasia ,medicine.disease ,medicine.anatomical_structure ,Myelodysplastic Syndromes ,Acute Disease ,Immunology ,Bone marrow ,Complication ,business ,Precancerous Conditions ,Congenital disorder - Abstract
Clinical evidence for a link between aplastic anaemia, paroxysmal nocturnal haemoglobinuria (PNH) and hypoplastic leukaemia is provided by studies of clonal disorders, which may be a complication of congenital or acquired aplastic anaemia. Fanconi's anaemia is the most common congenital disorder and leukaemia occurs in at least 10% of cases. In acquired aplastic anaemia, a high incidence of myelodysplastic syndrome (MDS) was noted in patients with aplastic anaemia, seemingly cured of their aplasia by antilymphocyte globulins (ALG). In a recent survey, the 10-year cumulative incidence rates were 9.6% for MDS, 6.6% for acute leukaemia (115-fold higher than in the general population). Biological evidence is provided by bone marrow morphology, as a certain degree of dysmyelopoiesis is not unusual in aplastic anaemia. Cytogenetic analyses in aplastic anaemia are scarce, but data have shown clonal cytogenetic abnormalities at diagnosis in otherwise typical aplastic anaemia. Recently, flow cytometry to assess the glycosyl-phosphatidylinositol (GPI) molecule defect in PNH has demonstrated that a significant proportion of patients with otherwise typical aplastic anaemia have, in fact, a GPI defect due to alterations within the PIG-A gene. Finally, aplastic anaemia patients were recently reported to have molecular evidence of clonal haematopoiesis; this must now be discussed in light of recent clonality studies in normal individuals. The clinical and biological evidence for a link between aplastic anaemia, PNH and hypoplastic leukaemia allows the generation of a model of aplastic anaemia as a possible pre-pre-leukaemic disorder.
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- 2009
205. Combined intensive immunosuppression and eculizumab for aplastic anemia in the context of hemolytic paroxysmal nocturnal hemoglobinuria: a retrospective analysis
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Pagliuca, S, primary, Risitano, A M, additional, De Fontbrune, F S, additional, Robin, M, additional, Iori, A P, additional, Marotta, S, additional, Michonneau, D, additional, Villate, A, additional, Desmier, D, additional, Socié, G, additional, and De Latour, R P, additional
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- 2017
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206. What is the outcome in patients with acute leukaemia who survive severe acute graft-versus-host disease?
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Ringdén, O., primary, Labopin, M., additional, Sadeghi, B., additional, Mailhol, A., additional, Beelen, D., additional, Fløisand, Y., additional, Ghavamzadeh, A., additional, Finke, J., additional, Ehninger, G., additional, Volin, L., additional, Socié, G., additional, Kröger, N., additional, Stuhler, G., additional, Ganser, A., additional, Schmid, C., additional, Giebel, S., additional, Mohty, M., additional, and Nagler, A., additional
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- 2017
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207. ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (ALLO-HSCT) FOR PATIENTS WITH RELAPSED/REFRACTORY SYSTEMIC ANAPLASTIC LARGE CELL LYMPHOMA (R/R SALCL). A RETROSPECTIVE ANALYSIS OF THE LYMPHOMA WORKING PARTY-EBMT.
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Domingo Domenech, E., primary, Boumendil, A., additional, Climent, F., additional, Socié, G., additional, Kroschinsky, F., additional, Finel, H., additional, Vandenbergue, E., additional, Nemet, D., additional, Stelljes, M., additional, Bittenbring, J., additional, Montoto, S., additional, Sureda, A., additional, and Dreger, P., additional
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- 2017
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208. BRENTUXIMAB VEDOTIN FOR RELAPSED HODGKIN LYMPHOMA AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: a RETROSPECTIVE STUDY OF THE EBMT LYMPHOMA WORKING PARTY
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Bazarbachi, A., primary, Boumendil, A., additional, Finel, H., additional, Mohty, M., additional, Castagna, L., additional, Blaise, D., additional, Peggs, K., additional, Afanasyev, B., additional, Diez-Martin, J., additional, Corradini, P., additional, Socié, G., additional, Robinson, S., additional, Gutiérrez-García, G., additional, Bonifazi, F., additional, Yakoub-Agha, I., additional, Gülbas, Z., additional, Bloor, A., additional, Delage, J., additional, Esquirol, A., additional, Malladi, R., additional, Scheid, C., additional, Ghesquières, H., additional, Montoto, S., additional, Dreger, P., additional, and Sureda, A., additional
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- 2017
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209. PV-0042: Fractionated-TBI schedules prior to allograft: Study from the Acute Leukemia Working Party (EBMT)
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Belkacemi, Y., primary, Labopin, M., additional, Giebel, S., additional, MiszyK, L., additional, Loganadane, G., additional, Michallet, M., additional, Socié, G., additional, Schaap, N., additional, Cornelissen, J., additional, Yakoub-Agha, I., additional, and Nagler, A., additional
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- 2017
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210. Efficacité et tolérance du ruxolitinib (JAKAVI) dans la GVH cutanée chronique sclérodermiforme cortico-résistante
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Hurabielle, C., primary, Fontbrune, F. Sicre de, additional, Robin, M., additional, Moins-Teisserenc, H., additional, Coman, T., additional, Jachiet, M., additional, Cassius, C., additional, Chasset, F., additional, Bagot, M., additional, Peffault de Latour, R., additional, Socié, G., additional, and Bouaziz, J.-D., additional
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- 2016
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211. Syndrome dermato-pulmonaire avec anticorps anti-MDA5 après allogreffe de cellules souches hématopoïétiques
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Lepelletier, C., primary, Bengoufa, D., additional, Lyes, Z., additional, de Masson, A., additional, Chasset, F., additional, Jachiet, M., additional, Michonneau, D., additional, Robin, M., additional, Peffault-de-Latour, R., additional, Sicre-de-Fontbrune, F., additional, Tandjaoui-Lambiotte, Y., additional, Bensussan, A., additional, Rybojad, M., additional, Tazi, A., additional, Bagot, M., additional, Socié, G., additional, Bergeron, A., additional, and Bouaziz, J.-D., additional
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- 2016
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212. Myeloablative versus reduced intensity allogeneic stem cell transplantation for relapsed/refractory Hodgkin's lymphoma in recent years: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
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Genadieva-Stavrik, S., primary, Boumendil, A., additional, Dreger, P., additional, Peggs, K., additional, Briones, J., additional, Corradini, P., additional, Bacigalupo, A., additional, Socié, G., additional, Bonifazi, F., additional, Finel, H., additional, Velardi, A., additional, Potter, M., additional, Bruno, B., additional, Castagna, L., additional, Malladi, R., additional, Russell, N., additional, and Sureda, A., additional
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- 2016
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213. The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
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Rubio MT, Labopin M, Blaise D, Socié G, Contreras RR, Chevallier P, Sanz MA, Vigouroux S, Huynh A, Shimoni A, Bulabois CE, Caminos N, López-Corral L, Nagler A, and Mohty M
- Abstract
The impact of the intensity of graft-versus-host-disease immunoprophylaxis on transplantation outcomes in patients undergoing transplantation following reduced-intensity conditioning is unclear. This study addresses this issue in 228 adult patients above 50 years of age with acute myeloid leukemia in first complete remission given peripheral blood stem cells from HLA-identical siblings after fludarabine and 2 days of intravenous busulfan reduced-intensity conditioning. A total of 152 patients received anti-thymocyte globulin, either in combination with cyclosporine A in 86 patients (group 1), or with cyclosporine A and mycophenolate mofetil or short course methotrexate in 66 patients (group 2). The remaining 76 patients did not receive anti-thymocyte globulin but were given cyclosporine A and methotrexate or mycophenolate mofetil (group 3). Incidences of grade II-IV acute graft-versus-host-disease were comparable in the three groups (16.5%, 29.5% and 19.5% in groups 1, 2 and 3, respectively, P= 0.15). In multivariate analysis, the absence of anti-thymocyte globulin was the only factor associated with a higher risk of chronic graft-versus-host-disease (P= 0.005), while the use of triple immunosuppression (group 3) was associated with an increased risk of relapse (P= 0.003). In comparison to anti-thymocyte globulin and cyclosporine A alone, the other two strategies of graft-versus-host-disease prophylaxis were associated with reduced leukemia-free survival and overall survival (P= 0.001 for each parameter), independently of the dose of anti-thymocyte globulin. These data suggest that fine tuning of the intensity of this prophylaxis can affect the out-come of transplantation and that anti-thymocyte globulin and cyclosporine A alone should be the preferred combination with the fludarabine-busulfan reduced-intensity conditioning regimen and sibling donors.
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- 2015
214. Allogeneic hematopoietic stem cell transplantation for patients with relapsed/refractory systemic anaplastic large cell lymphoma. A retrospective analysis of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation
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Domingo-Domènech, E., Boumendil, A., Climent, F., Socié, G., Kroschinsky, F., Finel, H., Vandenbergue, E., Nemet, D., Stelljes, M., Bittenbring, J. T., Robinson, S., Montoto, S., Sureda, A., and Dreger, P.
- Abstract
Information regarding the curative role of allogeneic stem cell transplantation (allo-HCT) in systemic anaplastic large cell lymphoma (sALCL) is scarce. We analyzed the results of allo-HCT in patients with relapsed/refractory sALCL with special emphasis on the role of brentuximab vedotin (BV) as a bridge to allo-HCT. Forty-four patients (24 females, median age 38 years) with sALCL were included. Twenty-three patients (52%) received BV before allo-HCT; BV-treated patients were more heavily pretreated (≥3 lines of therapy in 74% vs. 38%, p= 0.04). Twenty-three patients (52%) were in complete remission (CR) at allo-HCT. Three-year nonrelapse mortality and incidence of relapse (IR) after allo-HCT were 7% and 40%, respectively. With a median follow-up of 39 (12–69) months for survivors, 3-year progression-free survival (PFS) and overall survival were 53% and 74%, respectively. Univariate analysis showed that heavily pretreated patients and those not in CR had a higher IR and a lower PFS. The use of BV before transplant did not impact on any of the outcomes. Allo-HCT is a curative therapeutic strategy in a significant proportion of patients with relapsed/refractory sALCL; BV does not seem to modify transplant-related outcomes but might be able to render more patients candidates for this curative treatment.
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- 2020
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215. Multicenter Outbreak of Infections by Saprochaete clavata , an Unrecognized Opportunistic Fungal Pathogen
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Vaux, Sophie, Criscuolo, Alexis, Desnos-Ollivier, Marie, Diancourt, Laure, Tarnaud, Chloé, Vandenbogaert, Matthias, Brisse, Sylvain, Coignard, Bruno, Dromer, Françoise, Garcia-Hermoso, Dea, Blanc, Catherine, Hoinard, Damien, Lortholary, Olivier, Bretagne, Stéphane, Thiolet, Jean-Michel, de Valk, Henriette, Courbil, Rémi, Chabanel, Anne, Simonet, Marion, Maire, Francoise, Jbilou, Saadia, Tiberghien, Pierre, Blanchard, Hervé, Venier, Anne-Gaëlle, Bernet, Claude, Simon, Loïc, Sénéchal, Hélène, Pouchol, Elodie, Angot, Christiane, Ribaud, Patricia, Socié, G., Flèche, M., Brieu, Nathalie, Lagier, Evelyne, Chartier, Vanessa, Allegre, Thierry, Maulin, Laurence, Lanic, Hélène, Tilly, Hervé, Bouchara, Jean-Philippe, Pihet, Marc, Schmidt, Aline, Kouatchet, Achille, Vandamme, Yves-Marie, Ifrah, Norbert, Mercat, Alain, Accoceberry, Isabelle, Albert, Olivier, Leguay, Thibaut, Rogues, Anne-Marie, Bonhomme, Julie, Reman, Oumédaly, Lesteven, Claire, Poirier, Philippe, Chabrot, Cécile Molucon, Calvet, Laure, Baud, Olivier, Cambon, Monique, Farkas, Jean Chistophe, Lafon, Bruno, Dalle, Frédéric, Caillot, Denis, Lazzarotti, Aline, Aho, Serge, Combret, Sandrine, Facon, Thierry, Sendid, Boualem, Loridant, Séverine, Louis, Terriou, Cazin, Bruno, Grandbastien, Bruno, Bourgeois, Nathalie, Lotthé, Anne, Cartron, Guillaume, Ravel, Christophe, Colson, Pascal, Gaudard, Philippe, Bonmati, Caroline, Simon, Loic, Rabaud, Christian, Machouart, Marie, Poisson, Didier, Carp, Diana, Meunier, Jérôme, Gaschet, Anne, Miquel, Chantal, Sanhes, Laurence, Ferreyra, Milagros, Leibinger, Franck, Geudet, Philippe, Toubas, Dominique, Himberlin, Chantal, Bureau-Chalot, Florence, Delmer, Alain, Favennec, Loïc, Gargala, Gilles, Michot, Jean-Baptiste, Girault, Christophe, David, Marion, Leprêtre, Stéphane, Jardin, Fabrice, Honderlick, Pierre, Caille, Vincent, Cerf, Charles, Cassaing, Sophie, Recher, Christian, Picard, Muriel, Protin, Caroline, Huguet, Françoise, Huynh, Anne, Ruiz, Jean, Riu-Poulenc, Béatrice, Letocart, Philippe, Marchou, Bruno, Verdeil, Xavier, Cavalié, Laurent, Chauvin, Pamela, Iriart, Xavier, Valentin, Alexis, Bouvet, Emmanuelle, Delmas-Marsalet, Béatrice, Jeblaoui, Asma, Kassis-Chikhani, Najiby, Mühlethaler, Konrad, Zimmerli, Stefan, Zalar, Polona, Sánchez-Reus, Ferran, Gurgui, Merce, Institut de Veille Sanitaire (INVS), Génotypage des Pathogènes et Santé Publique (Plate-forme) (PF8), Institut Pasteur [Paris], Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunologie des Infections fongiques - immunology of fungal infections, Génomique évolutive des Microbes / Microbial Evolutionary Genomics, Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire (CNRMA), Institut Pasteur [Paris] (IP), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
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Genotype ,Molecular Sequence Data ,Geotrichum-capitatum ,Fungal contamination ,Sequence Homology ,High-throughput ,Diseases ,Fungus ,Sequences ,Microbiology ,Saprochaete clavata ,Disease Outbreaks ,03 medical and health sciences ,Yeasts ,Virology ,Cluster Analysis ,DNA, Fungal ,Mycological Typing Techniques ,Clade ,Pathogen ,Genotyping ,Phylogeny ,Alignment ,Blastoschizomyces-capitatus ,030304 developmental biology ,Cross Infection ,Molecular Epidemiology ,0303 health sciences ,Leukemia ,biology ,030306 microbiology ,Outbreak ,Sequence Analysis, DNA ,Agents ,Fungal pathogen ,biology.organism_classification ,QR1-502 ,3. Good health ,Molecular Typing ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Mycoses ,Saccharomycetales ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Health Facilities ,France ,Research Article - Abstract
Rapidly fatal cases of invasive fungal infections due to a fungus later identified as Saprochaete clavata were reported in France in May 2012. The objectives of this study were to determine the clonal relatedness of the isolates and to investigate possible sources of contamination. A nationwide alert was launched to collect cases. Molecular identification methods, whole-genome sequencing (WGS), and clone-specific genotyping were used to analyze recent and historical isolates, and a case-case study was performed. Isolates from thirty cases (26 fungemias, 22 associated deaths at day 30) were collected between September 2011 and October 2012. Eighteen cases occurred within 8 weeks (outbreak) in 10 health care facilities, suggesting a common source of contamination, with potential secondary cases. Phylogenetic analysis identified one clade (clade A), which accounted for 16/18 outbreak cases. Results of microbiological investigations of environmental, drug, or food sources were negative. Analysis of exposures pointed to a medical device used for storage and infusion of blood products, but no fungal contamination was detected in the unused devices. Molecular identification of isolates from previous studies demonstrated that S. clavata can be found in dairy products and has already been involved in monocentric outbreaks in hematology wards. The possibility that S. clavata may transmit through contaminated medical devices or can be associated with dairy products as seen in previous European outbreaks is highly relevant for the management of future outbreaks due to this newly recognized pathogen. This report also underlines further the potential of WGS for investigation of outbreaks due to uncommon fungal pathogens., IMPORTANCE Several cases of rapidly fatal infections due to the fungus Saprochaete clavata were reported in France within a short period of time in three health care facilities, suggesting a common source of contamination. A nationwide alert collected 30 cases over 1 year, including an outbreak of 18 cases over 8 weeks. Whole-genome sequencing (WGS) was used to analyze recent and historical isolates and to design a clade-specific genotyping method that uncovered a clone associated with the outbreak, thus allowing a case-case study to analyze the risk factors associated with infection by the clone. The possibility that S. clavata may transmit through contaminated medical devices or can be associated with dairy products as seen in previous European outbreaks is highly relevant for the management of future outbreaks due to this newly recognized pathogen.
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- 2014
216. Trends in patient outcome over the past two decades following allogeneic stem cell transplantation for acute myeloid leukaemia: an ALWP/EBMT analysis.
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Canaani, J., Beohou, E., Labopin, M., Ghavamzadeh, A., Beelen, D., Hamladji, R.‐M., Niederwieser, D., Volin, L., Markiewicz, M., Arnold, R., Mufti, G., Ehninger, G., Socié, G., Kröger, N., Mohty, M., Nagler, A., and Hamladji, R-M
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STEM cell transplantation ,GRAFT versus host disease - Abstract
Background: Outcomes for patients with acute myeloid leukaemia (AML) undergoing allogeneic stem cell transplantation (allo-SCT) have significantly improved in recent years.Objectives: To assess the incremental improvement of transplanted AML patients in the last two decades.Methods: Patients included in this analysis were adult AML patients who underwent allo-SCT from an HLA-matched sibling donor (MSD) or HLA-matched unrelated donor (MUD) in first remission. Patient outcomes were assessed between three cohorts according to the year of transplant (1993-2002, 2003-2007 and 2008-2012).Results: The analysis comprised a total of 20 187 patients of whom 4763 were transplanted between 1993 and 2002, 5835 in 2003 and 2007, and 9589 in 2008 and 2012. In multivariate analysis, leukaemia-free survival (LFS) rates were significantly improved in more recently transplanted patients compared to patients transplanted in 1993-2002 [Hazard ratio (HR) = 0.84, confidence interval (CI) 95%, 0.77-0.92; P = 0.003], a benefit which also extended to improved overall survival (OS; HR = 0.8, CI 95%, 0.73-0.89; P < 0.0001), and decreased nonrelapse mortality (NRM) rates (HR = 0.65, CI 95%, 0.56-0.75; P < 0.0001). Subset analysis revealed that in MSD, the rates of LFS, NRM and OS significantly improved in patients in the more recent cohort with similar results also seen in MUD. Finally, the incidence of acute graft-versus-host disease (GVHD) was significantly reduced leading to improved GVHD-free/relapse-free survival (GRFS) rates in more recently transplanted patients.Conclusion: Outcome of allo-SCT for AML patients has markedly improved in the last two decades owing to decreased nonrelapse mortality and improved rates of leukaemia-free survival resulting in significantly longer survival. [ABSTRACT FROM AUTHOR]- Published
- 2019
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217. French Intensive Care Society, International congress - Réanimation 2016
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Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, Klein, I, Chau, F, Lefort, A, Desilles, J, Michel, J, Mazighi, M, Salem, O, Demeret, S, Bolgert, F, Sharshar, T, Grabli, D, Arib, S, Crippa, I, Soummer, A, Engrand, N, Guedin, P, Aldea, S, Cerf, C, Desailly, V, Pasquier, P, Brun, P, Roux, D, Latournerie, G, Kasprzyk, L, Grosjean, V, Latreche, A, Habert, P, Huot, S, Jobin, T, Tesnière, A, Dreyfuss, D, Ricard, J, Mignon, A, Gaudry, S, Laithier, F, Kimmoun, A, Chouihed, T, Albizzati, S, Camenzind, E, Vanhuyse, F, Levy, B, Cour, M, Venet, F, Hernu, R, Demaret, J, Monneret, G, Argaud, L, Dumas, F, Lamhaut, L, Rosencher, J, Pène, F, Varenne, O, Carli, P, Jouven, X, Spaulding, C, Cariou, A, Geri, G, Bonnetain, F, Marijon, E, Empana, J, Mirouse, A, Resche Rigon, M, Mayaux, J, Rabbat, A, Meert, A, Benoit, D, Bruneel, F, Azoulay, E, Dupuis, C, Schwebel, C, Ruckly, S, Goldgran Toledano, D, Marcotte, G, Lafarge, A, Pichereau, C, Theodose, I, Scotto, M, Kemlin, D, Ghrenassia, E, Schlemmer, B, Vimpere, D, Galicier, L, Contou, D, Guérot, E, Grimaldi, D, Ricome, S, Maury, E, Plantefève, G, Dessap, A, Brun Buisson, C, de Prost, N, Dubé, B, Delemazure, J, Dres, M, Rousseau, L, Drouot, X, Diaz, V, Rebollar, Y, Frat, J, Thille, A, Aissa, D, Coquet, P, Ruiz, J, Ferre, F, Hoarau, L, Riu Poulenc, B, Bataille, B, Silva, S, Baudel, J, Bigé, N, Tahiri, J, Dubée, V, Guidet, B, Ait Oufella, H, Jinglun, L, Shen, F, Bailly, S, Leroy, O, Montravers, P, Constantin, J, Dupont, H, Guillemot, D, Lortholary, O, Perrigault, P, Gangneux, J, Razazi, K, Mekontso Dessap, A, Jansen, C, Lecronier, M, Sandrine, V, Mira, J, Blein, S, Marin, N, Rousseau, C, Charpentier, J, Pachot, A, Hraiech, S, Bordes, J, De, L, Mège, J, Forel, J, Guervilly, C, Adda, M, Raoult, D, Papazian, L, Kentish Barnes, N, Cohen Solal, Z, Souppart, V, Kerhuel, L, Haubertin, C, Exbrayat, I, Rozières, E, Argain, A, Suc, A, Vignes, M, Cougot, P, Fourcade, O, Brunel, E, Messika, J, Tubach, F, Dubief, E, Pasquet, B, Guillo, S, Pierron, C, Grimaud, M, Farnoux, C, Maillard, A, Decavèle, M, 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Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE
- Abstract
Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
- Published
- 2016
218. Myeloablative versus reduced intensity allogeneic stem cell transplantation for relapsed/refractory Hodgkin's lymphoma in recent years: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
- Author
-
Genadieva Stavrik, S, Boumendil, A, Dreger, P, Peggs, K, Briones, J, Corradini, P, Bacigalupo, Andrea, Socié, G, Bonifazi, F, Finel, H, Velardi, A, Potter, M, Bruno, Brunella, Castagna, Luigi, Malladi, R, Russell, N, Sureda, A., Bacigalupo, Andrea (ORCID:0000-0002-9119-567X), Genadieva Stavrik, S, Boumendil, A, Dreger, P, Peggs, K, Briones, J, Corradini, P, Bacigalupo, Andrea, Socié, G, Bonifazi, F, Finel, H, Velardi, A, Potter, M, Bruno, Brunella, Castagna, Luigi, Malladi, R, Russell, N, Sureda, A., and Bacigalupo, Andrea (ORCID:0000-0002-9119-567X)
- Abstract
BACKGROUND: To evaluate long-term outcome of myeloablative allogeneic stem cell transplantation (allo-SCT) (MAC) versus reduced-intensity allo-SCT (RIC) in patients with relapsed/refractory Hodgkin's lymphoma (HL) in recent years. PATIENTS AND METHODS: A total of 312 patients (63 MAC and 249 RIC) with relapsed/refractory HL who received allo-SCT between 2006 and 2010 and were reported to the EBMT Database were included in the study. RESULTS: With a median follow-up for alive patients of 56 (26-73) months, there were no significant differences in non-relapse mortality (NRM) between MAC and RIC. Relapse rate (RR) was somewhat lower in the MAC group (41% versus 52% at 24 months, P = 0.16). This lower RR translated into a marginal improvement in event-free survival (EFS) for the MAC group (48% versus 36% at 24 months, P = 0.09) with no significant differences in overall survival (73% for MAC and 62% for RIC at 24 months, P = 0.13). Multivariate analysis after adjusting for disease status at the time of allo-SCT showed that the use of MAC was of borderline statistical significance for predicting a lower RR and EFS [HR 0.7, 95% CI (0.5-1.0), P = 0.1] and [HR 0.7, 95% CI (0.5-1.0), P = 0.07], respectively, after allo-SCT. CONCLUSIONS: With modern transplant practices, the NRM associated with MAC for HL has strongly decreased, resulting into non-significant improvement of EFS because of a somewhat better disease control compared with RIC transplants. The intensity of conditioning regimens should be considered when designing individual allo-SCT strategies or clinical trials in patients with relapsed/refractory HL. © The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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- 2016
219. Outcome of Allogeneic Stem Cell Transplantation for Patients Transformed to Myelodysplastic Syndrome or Leukemia from Severe Aplastic Anemia: A Report from the MDS Subcommittee of the Chronic Malignancies Working Party and the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
- Author
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Hussein, Aa, Halkes, Cm, Socié, G, Tichelli, A, Borne, Pa, Schaap, Mn, Foa, Roberto, Ganser, A, Dufour, C, Bacigalupo, A, Locasciulli, A, Aljurf, M, Peters, C, Robin, M, van Biezen AA, Volin, L, De Witte, T, Marsh, J, Passweg, Jr, Kröger, N, for the Severe Aplastic Anemia, Chronic Malignancies Working Parties of the European Group for Blood, and Marrow, Transplantation
- Subjects
Adult ,Male ,medicine.medical_specialty ,Transplantation Conditioning ,Severe aplastic anemia ,Adolescent ,medicine.medical_treatment ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,Acute myelogenous leukemia ,Hematopoietic stem cell transplantation ,Myelogenous ,Young Adult ,Internal medicine ,hemic and lymphatic diseases ,medicine ,Humans ,Transplantation, Homologous ,Child ,Aged ,Transplantation ,Leukemia ,Marrow transplantation ,business.industry ,Anemia, Aplastic ,Infant ,Hematology ,Middle Aged ,medicine.disease ,Severe Aplastic Anemia ,Europe ,Treatment Outcome ,surgical procedures, operative ,Allogeneic hsct ,Child, Preschool ,Myelodysplastic Syndromes ,Immunology ,Female ,Stem cell ,Neoplasm Recurrence, Local ,business ,Myelodysplastic syndrome - Abstract
Item does not contain fulltext One hundred and forty patients who had undergone hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) transformation after treatment of severe aplastic anemia (SAA) were identified in the European Group for Blood and Marrow Transplantation (EBMT) database. The median age at HSCT was 29 years (range, 1 to 66 years). The transplant donor was related in 49% cases and unrelated in 51% cases. The 5-year probability of relapse was 17%, and that of nonrelapse mortality was 41%. The 5-year overall survival was 45% +/- 9%, better for patients untreated and patients in remission compared with patients with refractory disease. Our data indicate that allogeneic HSCT leads to prolonged survival in close to one-half of the patients transforming to MDS or AML from SAA.
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- 2014
220. Acute kidney injury in critically ill allo-HSCT recipients
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Lara Zafrani, Marie-Noëlle Peraldi, Etienne Lengliné, Emmanuel Canet, Socié G, and Elie Azoulay
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Male ,Transplantation ,medicine.medical_specialty ,Leukemia ,Critical Care ,Lymphoma ,Critically ill ,business.industry ,MEDLINE ,Allo hsct ,Acute kidney injury ,Hematopoietic Stem Cell Transplantation ,Hematology ,medicine.disease ,Intensive Care Units ,medicine ,Humans ,Female ,Intensive care medicine ,business - Published
- 2014
221. Early administration of donor lymphocyte infusions upon molecular relapse after allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia: a study by the Chronic Malignancies Working Party of the EBMT
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Chalandon, Y, Passweg, J, Guglielmi, C, Iacobelli, S, Apperley, J, Schaap, N, Finke, J, Robin, M, Fedele, R, Bron, D, Yakoub Agha, I, van Biezen, A, de Witte, T, Kröger, N, Olavarria, E, Socié, G, Schanz, U, Boogaerts, M, Ljungman, P, Rovira, M, Broom, A, Foa, R, Poiré, X, Schattenberg, A, Bandini, B, Veys, P, Chevallier, P, Leblond, V, Paneesha, S, Irrera, G, Vitek, A, Russel, N, Jindra, P, San Miguel, J, de Rosa, G, Bloor, A, Butler, A, Arnold, R, and Ludwig, H
- Subjects
Male ,medicine.medical_specialty ,Neoplasm, Residual ,Lymphocyte Transfusion ,Graft vs Host Disease/immunology/mortality/pathology/therapy ,Time Factors ,Lymphocyte ,medicine.medical_treatment ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,Graft vs Host Disease ,Hematopoietic stem cell transplantation ,Gastroenterology ,Settore MED/01 - Statistica Medica ,Median follow-up ,Recurrence ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Survival analysis ,ddc:616 ,business.industry ,Siblings ,Hematopoietic Stem Cell Transplantation ,Myeloid leukemia ,Articles ,Hematology ,Survival Analysis ,Transplantation ,Neoplasm, Residual/immunology/mortality/pathology/therapy ,medicine.anatomical_structure ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology/mortality/pathology/therapy ,Immunology ,Disease Progression ,Female ,Stem cell ,business ,Unrelated Donors ,Follow-Up Studies - Abstract
Contains fulltext : 137865.pdf (Publisher’s version ) (Open Access) Patients with chronic myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation may be treated by tyrosine kinase inhibitors and/or by donor lymphocyte infusions. The best strategies and timing of administration of lymphocytes are unclear. We analyzed 155 patients who relapsed after allogeneic stem cell transplantation with disease detectable only by molecular methods and who subsequently received lymphocytes. Transplants were performed in first chronic phase (n=125) or in advanced disease (n=29) from identical siblings (n=84) or unrelated donors (n=71) between 1986 and 2003. They received lymphocytes either during molecular relapse (n=85) or upon progression to more advanced disease (1993 to 2004). The median interval from relapse to lymphocyte infusion was 210 (0-1673) days. The median follow up after it was 46 (3-135) months. Overall survival was 76+/-4% at five years after lymphocyte infusions (89+/-8% with sibling donors and 63+/-13% with unrelated donors (P=0.003)). Survival was 69+/-14% when lymphocytes were given within six months of the detection of molecular relapse and 81+/-10% (P=0.061) when given later; 81+/-11% if given at molecular relapse versus 71+/-12% (P=0.26) with more advanced disease. In multivariate analysis survival was worse if the donor was unrelated (HR 2.54 (95% CI: 1.15-5.53), P=0.021) and better with lymphocyte infusions beyond six months from molecular relapse (HR 0.4 (95%CI: 0.19-0.84), P=0.018). These data confirm the remarkable efficacy of lymphocyte infusions for this disease. There appears to be no advantage from administering it early upon detection of molecular relapse in patients who received allogeneic stem cell transplantation for chronic myeloid leukemia.
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- 2014
222. 431 APRIL levels are associated with disease activity in human chronic graft versus host disease
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Chasset, F., primary, de Masson, A., additional, Le Buanec, H., additional, xhaar, A., additional, Robin, M., additional, Bengoufa, D., additional, Bagot, M., additional, bensussan, A., additional, Socié, G., additional, and Bouaziz, J., additional
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- 2016
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223. Efficacy of eculizumab against Eosinophilic Fasciitis associated with Paroxysmal Nocturnal Haemoglobinuria
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Frumholtz, L., primary, Sebert, M., additional, de Masson, A., additional, Attias, P., additional, Ades, L., additional, Roux, J., additional, Jachiet, M., additional, Cabannes‐Hamy, A., additional, Elena Noguera, M., additional, Attencourt, C., additional, Bagot, M., additional, Socié, G., additional, Rybojad, M., additional, de La Tour, R. Peffault, additional, and Bouaziz, J.D., additional
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- 2016
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224. Conditioning intensity in middle-aged patients with AML in first CR : No advantage for myeloablative regimens irrespective of the risk group-an observational analysis by the Acute Leukemia Working Party of the EBMT
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Passweg, J. R., Labopin, M., Cornelissen, J., Volin, L., Socié, G., Huynh, A., Tabrizi, R., Wu, D., Craddock, C., Schaap, N., Kuball, J., Chevallier, P., Cahn, J. Y., Blaise, D., Ghavamzadeh, A., Bilger, K., Ciceri, F., Schmid, C., Giebel, S., Nagler, A., Mohty, M., Passweg, J. R., Labopin, M., Cornelissen, J., Volin, L., Socié, G., Huynh, A., Tabrizi, R., Wu, D., Craddock, C., Schaap, N., Kuball, J., Chevallier, P., Cahn, J. Y., Blaise, D., Ghavamzadeh, A., Bilger, K., Ciceri, F., Schmid, C., Giebel, S., Nagler, A., and Mohty, M.
- Published
- 2015
225. Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with philadelphia chromosome positive acute lymphoblastic leukemia
- Author
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Brissot, E. (Eolia), Labopin, M. (Myriam), Beckers, M.M. (Marielle M.), Socié, G. (Gerard), Rambaldi, A. (Alessandro), Volin, L. (Liisa), Finke, J. (Jürgen), Lenhoff, S. (S.), Kröger, N. (Nicolaus), Ossenkoppele, G.J. (Gert), Craddock, C.F. (Charles), Yakoub-Agha, I. (Ibrahim), Gürman, G. (Günhan), Russell, N.H. (Nigel H.), Aljurf, M. (Mahmoud), Potter, M. (M.), Nagler, A. (Arnon), Ottmann, O.G., Cornelissen, J.J. (Jan), Esteve, J. (Jordi), Mohty, M. (Mohamad), Brissot, E. (Eolia), Labopin, M. (Myriam), Beckers, M.M. (Marielle M.), Socié, G. (Gerard), Rambaldi, A. (Alessandro), Volin, L. (Liisa), Finke, J. (Jürgen), Lenhoff, S. (S.), Kröger, N. (Nicolaus), Ossenkoppele, G.J. (Gert), Craddock, C.F. (Charles), Yakoub-Agha, I. (Ibrahim), Gürman, G. (Günhan), Russell, N.H. (Nigel H.), Aljurf, M. (Mahmoud), Potter, M. (M.), Nagler, A. (Arnon), Ottmann, O.G., Cornelissen, J.J. (Jan), Esteve, J. (Jordi), and Mohty, M. (Mohamad)
- Abstract
This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia. This retrospective analysis from the EBMT Acute Leukemia Working Party included 473 de novoPhiladelphia chromosome-positive acute lymphoblastic leukemia patients in first complete remission who underwent an allogeneic stem cell transplantation using a human leukocyte antigen-identical sibling or human leukocyte antigen-matched unrelated donor between 2000 and 2010. Three hundred and ninety patients received tyrosine kinase inhibitors before transplant, 329 at induction and 274 at consolidation. Kaplan-Meier estimates of leukemia-free survival, overall survival, cumulative incidences of relapse incidence, and non-relapse mortality at five years were 38%, 46%, 36% and 26%, respectively. In multivariate analysis, tyrosine-kinase inhibitors given before allogeneic stem cell transplantation was associated with a better overall survival (HR=0.68; P=0.04) and was associated with lower relapse incidence (HR=0.5;P=0.01). In the post-transplant period, multivariate analysis identified prophylactic tyrosine-kinase inhibitor administration to be a significant factor for improved leukemia-free survival (HR=0.44; P=0.002) and overall survival (HR=0.42; P=0.004), and a lower relapse incidence (HR=0.40; P=0.01). Over the past decade, administration of tyrosine kinase inhibitors before allogeneic stem cell transplantation has significantly improved the long-term allogeneic stem cell transp
- Published
- 2015
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226. Conditioning intensity in middle-aged patients with AML in first CR: No advantage for myeloablative regimens irrespective of the risk group-an observational analysis by the Acute Leukemia Working Party of the EBMT
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MS Hematologie, Infection & Immunity, Cancer, Passweg, J. R., Labopin, M., Cornelissen, J., Volin, L., Socié, G., Huynh, A., Tabrizi, R., Wu, D., Craddock, C., Schaap, N., Kuball, J., Chevallier, P., Cahn, J. Y., Blaise, D., Ghavamzadeh, A., Bilger, K., Ciceri, F., Schmid, C., Giebel, S., Nagler, A., Mohty, M., MS Hematologie, Infection & Immunity, Cancer, Passweg, J. R., Labopin, M., Cornelissen, J., Volin, L., Socié, G., Huynh, A., Tabrizi, R., Wu, D., Craddock, C., Schaap, N., Kuball, J., Chevallier, P., Cahn, J. Y., Blaise, D., Ghavamzadeh, A., Bilger, K., Ciceri, F., Schmid, C., Giebel, S., Nagler, A., and Mohty, M.
- Published
- 2015
227. Présence de populations lymphocytaires Th1, Th17 et Tc17 dans la réaction du greffon contre l’hôte chronique (GVHc) psoriasiforme
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Chasset, F., primary, Le-Buanec, H., additional, Sicre de Fontbrune, F., additional, De Masson, A., additional, Rivet, J., additional, Bergeron, A., additional, Frumholtz, L., additional, Robin, M., additional, Rybojad, M., additional, Roux, J., additional, Tazi, A., additional, Peffault de La Tour, R., additional, Bagot, M., additional, Socié, G., additional, Bensussan, A., additional, and Bouaziz, J.-D., additional
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- 2015
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228. Expansion de lymphocytes T régulateurs type 1 (Tr1) dans la GVH chronique humaine
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De Masson, A., primary, Bensussan, A., additional, le Buanec, H., additional, Chasset, F., additional, Bagot, M., additional, Socié, G., additional, and Bouaziz, J.-D., additional
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- 2015
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229. Influence of pre-existing invasive aspergillosis on allo-HSCT outcome: a retrospective EBMT analysis by the Infectious Diseases and Acute Leukemia Working Parties
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Penack, O, primary, Tridello, G, additional, Hoek, J, additional, Socié, G, additional, Blaise, D, additional, Passweg, J, additional, Chevallier, P, additional, Craddock, C, additional, Milpied, N, additional, Veelken, H, additional, Maertens, J, additional, Ljungman, P, additional, Cornelissen, J, additional, Thiebaut-Bertrand, A, additional, Lioure, B, additional, Michallet, M, additional, Iacobelli, S, additional, Nagler, A, additional, Mohty, M, additional, and Cesaro, S, additional
- Published
- 2015
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230. 15 HLA-MATCHED ALLOGENEIC STEM CELL TRANSPLANTATION IMPROVES OVERALL SURVIVAL OF HIGHER RISK MYELODYSPLASTIC SYNDROME
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Robin, M., primary, Porcher, R., additional, Ades, L., additional, Raffoux, E., additional, Michallet, M., additional, François, S., additional, Cahn, J.Y., additional, Delmer, A., additional, Wattel, E., additional, Vigouroux, S., additional, Bay, J.O., additional, Cornillon, J., additional, Huynh, A., additional, Nguyen, S., additional, Rubio, M.T., additional, Vincent, L., additional, Maillard, N., additional, Charbonnier, A., additional, de Latour, R. Peffault, additional, Oumedaly, R., additional, Dombret, H., additional, Fenaux, P., additional, and Socié, G., additional
- Published
- 2015
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231. A prospective registration study to determine feasibility of hematopoietic SCT in adults with acute leukemia: Planning, expectations and reality
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UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service d'hématologie, Labopin, M., Gorin, N.-C., Polge, E., Socié, G., Gurman, G., Gluckman, E., Jindra, P., Poire, Xavier, Schäfer-Eckart, K., Ruutu, T., Milone, G., Arcese, W., Mohty, M., Rocha, V., UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service d'hématologie, Labopin, M., Gorin, N.-C., Polge, E., Socié, G., Gurman, G., Gluckman, E., Jindra, P., Poire, Xavier, Schäfer-Eckart, K., Ruutu, T., Milone, G., Arcese, W., Mohty, M., and Rocha, V.
- Abstract
For adults with acute leukemia, it is important to know whether the therapeutic schemes initially planned were actually implemented. The European Group for Blood and Marrow transplantation Acute Leukemia Working Party prospectively followed 695 consecutive patients who were registered at the time of HLA typing. Of 304 patients with an available matched sibling donor (MSD), SCT was planned in 264, chemotherapy in 33 and autografting in 7. For the rest, an unrelated donor (UD) search was initiated in 198. Among these, 117 were transplanted, 114 received chemotherapy and 77 underwent autografting. Probabilities of receiving a planned treatment were 60 and 65% at 1 and 2 years, respectively. Patients scheduled to receive MSD SCT had an 82% probability, whereas those scheduled to undergo UD SCT had a 57% probability, of receiving their transplant at 1 year. The only factor associated with a lower probability of MSD SCT in first remission was delayed HLA typing (HR=0.82; P=0.03). One year after enrollment, 40% of patients did not follow their initial treatment plan. Because OS was 50% only at 3 years and only 57% of the patients without a MSD underwent SCT, this suggests room for improvement in outcomes for adults with acute leukemia. © 2014 Macmillan Publishers Limited. All rights reserved.
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- 2014
232. Lymphocytes B régulateurs et GVH chronique humaine
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De Masson, A., primary, Le Buanec, H., additional, Bagot, M., additional, Robin, M., additional, Parquet, N., additional, Peffault de Latour, R., additional, Bensussan, A., additional, Socié, G., additional, and Bouaziz, J.-D., additional
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- 2014
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233. Anticorps anti-récepteur de type 1 à l’angiotensine au cours de la réaction chronique du greffon contre l’hôte
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Bouaziz, J.-D., primary, Chiron, A., additional, Peffault de La Tour, R., additional, Bagot, M., additional, Socié, G., additional, and Bengoufa, D., additional
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- 2014
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234. Standard Versus Single Dose-Daily Fractionated Total Body Irradiation Schedules Prior to Allotransplant for Acute Leukemia: The Sarasin Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)
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Belkacemi, Y., Labopin, M., Sebastian, G., Loganadane, G.K., Miszyk, L., Michallet, M., Socie, G., Schaap, N.P., Jan, C.J., Agha, I.Y., Mohty, M., and Nagler, A.
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- 2017
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235. CMV-retinitis after haematopoietic stem cell transplantation; the final report on a survey from the EMBT Working Party for Infectious Diseases
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Larsson, K, Maertens, J, Arvidson, J, Juliusson, G, Einsele, H, Békássy, An, Lindmark, A, Gentile, G, De la Camara, R., Dekker, A, Zander, A, Socié, G, Boeckh, M, Ljungman, P, Cordonnier, C, and on behalf of the Infectious Diseases Working, Party.
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retinitis ,CMV ,transplantation - Published
- 2004
236. Pre-transplantation risk factors to develop sclerotic chronic GvHD after allogeneic HSCT: A multicenter retrospective study from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
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Detrait, M Y, primary, Morisset, S, additional, Peffault de Latour, R, additional, Yakoub-Agha, I, additional, Crocchiolo, R, additional, Tabrizi, R, additional, Bay, J-O, additional, Chevalier, P, additional, Barraco, F, additional, Raus, N, additional, Vigouroux, S, additional, Magro, L, additional, Mohty, M, additional, Milpied, N, additional, Blaise, D, additional, Socié, G, additional, and Michallet, M, additional
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- 2014
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237. Equivalent outcomes using reduced intensity or conventional myeloablative conditioning transplantation for patients aged 35 years and over with AML
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Sébert, M, primary, Porcher, R, additional, Robin, M, additional, Adès, L, additional, Boissel, N, additional, Raffoux, E, additional, Xhaard, A, additional, Dhedin, N, additional, Larghero, J, additional, Himberlin, C, additional, Delmer, A, additional, Fenaux, P, additional, Dombret, H, additional, Socié, G, additional, and de Latour, R P, additional
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- 2014
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238. R-10: Infections fongiques invasives survenant sous prophylaxie primaire par posaconazole en hématologie
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Lerolle, N., primary, Raffoux, E., additional, Socié, G., additional, Touratier, S., additional, Bretagne, S., additional, Molina, J.-M., additional, and Lafaurie, M., additional
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- 2014
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239. Allogeneic hematopoietic SCT for adults AML using i.v. BU in the conditioning regimen: outcomes and risk factors for the occurrence of hepatic sinusoidal obstructive syndrome
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Nagler, A, primary, Labopin, M, additional, Berger, R, additional, Bunjes, D, additional, Campos, A, additional, Socié, G, additional, Kröger, N, additional, Goker, H, additional, Yakoub-Agha, I, additional, Shimoni, A, additional, Mohty, M, additional, and Rocha, V, additional
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- 2014
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240. Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation
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Baron, F, primary, Labopin, M, additional, Blaise, D, additional, Lopez-Corral, L, additional, Vigouroux, S, additional, Craddock, C, additional, Attal, M, additional, Jindra, P, additional, Goker, H, additional, Socié, G, additional, Chevallier, P, additional, Browne, P, additional, Sandstedt, A, additional, Duarte, R F, additional, Nagler, A, additional, and Mohty, M, additional
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- 2014
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241. Disseminated cutaneous infection due to Mycobacterium chelonae following hematopoietic stem cell transplantation
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Ferry, C., primary, Saussine, A., additional, Bouaziz, J.D., additional, Xhaard, A., additional, Peffault de Latour, R., additional, Ribaud, P., additional, Robin, M., additional, Cambau, E., additional, and Socié, G., additional
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- 2014
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242. Effet de la photophérèse extracorporelle sur la fonction respiratoire des receveurs d’une allogreffe de cellules souches hématopoïétiques
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Rivière, F., primary, Chevret, S., additional, Schlemmer, F., additional, Parquet, N., additional, Bouaziz, J.-D., additional, Socié, G., additional, Tazi, A., additional, and Bergeron, A., additional
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- 2014
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243. Fasciite de Shulman et aplasie médullaire idiopathique : description de quatre cas et revue de 19 cas de la littérature
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De Masson, A., primary, Bouaziz, J.-D., additional, Peffault de Latour, R., additional, Benhamou, Y., additional, Moluçon-Chabrot, C., additional, Bay, J.-O., additional, Laquerrière, A., additional, Picquenot, J.-M., additional, Michonneau, D., additional, Leguy-Seguin, V., additional, Bonnotte, B., additional, Jardin, F., additional, Lévesque, H., additional, Socié, G., additional, Bagot, M., additional, and Rybojad, M., additional
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- 2013
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244. Étude rétrospective multicentrique de l’efficacité et de la tolérance de l’imatinib mésylate dans 39 cas de GVH chronique sclérodermiforme corticorésistante
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De Masson, A., primary, Bouaziz, J.-D., additional, Latour, R. Peffault de, additional, Wittnebel, S., additional, Ribaud, P., additional, Rubio, M.-T., additional, Micol, J.-B., additional, Suarez, F., additional, Nguyen, S., additional, Dalle, J.-H., additional, Yakouben, K., additional, Robin, M., additional, Xhaard, A., additional, Adès, L., additional, Bourhis, J.-H., additional, Rybojad, M., additional, Socié, G., additional, and Bagot, M., additional
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- 2013
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245. Allogreffe de cellules souches hématopoïétiques dans 37 cas de mycosis fongoïde transformé et autres lymphomes T cutanés primitifs de stade avancé
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De Masson, A., primary, Beylot-Barry, M., additional, Bouaziz, J.-D., additional, Aubin, F., additional, Garciaz, S., additional, d’Incan, M., additional, Dereure, O., additional, Dalle, S., additional, Dompmartin, A., additional, Suarez, F., additional, Adamski, H., additional, Battistella, M., additional, Rivet, J., additional, Vignon-Pennamen, M.-D., additional, Brice, P., additional, François, S., additional, Lissandre, S., additional, Turlure, P., additional, Hainaut, E., additional, Brissot, E., additional, Dulery, R., additional, Ravinet, A., additional, Servais, S., additional, Ingen-Housz-Oro, S., additional, Joly, P., additional, Socié, G., additional, and Bagot, M., additional
- Published
- 2013
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246. GVH cutanées chroniques ulcérées : spectre clinique et évolutif sur une cohorte rétrospective de 25 patients
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Jachiet, M., primary, de Masson, A., additional, Latour, R. Peffault de, additional, Bourhis, J.-H., additional, Robin, M., additional, Rybojad, M., additional, Xhaard, A., additional, Sicre de Fontbrune, F., additional, Suarez, F., additional, Barete, S., additional, Wittnebel, S., additional, Bagot, M., additional, Socié, G., additional, and Bouaziz, J.D., additional
- Published
- 2013
- Full Text
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247. Impact of FLT3 internal tandem duplication on the outcome of related and unrelated hematopoietic transplantation for adult acute myeloid leukemia in first remission: A retrospective analysis
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Brunet, S. (Salut), Labopin, M. (Myriam), Esteve, J. (Jordi), Cornelissen, J.J. (Jan), Socié, G. (Gerard), Iori, A.P. (Anna), Verdonck, L.F. (Leo), Volin, L. (Liisa), Gratwohl, A. (Alois), Sierra, J. (Jorge), Mohty, M. (Mohamad), Rocha, V. (Vanderson), Brunet, S. (Salut), Labopin, M. (Myriam), Esteve, J. (Jordi), Cornelissen, J.J. (Jan), Socié, G. (Gerard), Iori, A.P. (Anna), Verdonck, L.F. (Leo), Volin, L. (Liisa), Gratwohl, A. (Alois), Sierra, J. (Jorge), Mohty, M. (Mohamad), and Rocha, V. (Vanderson)
- Abstract
Purpose: Patients with acute myeloid leukemia (AML) and FLT3/internal tandem duplication (FLT3/ITD) have poor prognosis if treated with chemotherapy only. Whether this alteration also affects outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) remains uncertain. Patients and Methods: We analyzed 206 patients who underwent HLA-identical sibling and matched unrelated HSCTs reported to the European Group for Blood and Marrow Transplantation with a diagnosis of AML with normal cytogenetics and data on FLT3/ITD (present: n = 120, 58%; absent: n = 86, 42%). Transplantations were performed in first complete remission (CR) after myeloablative conditioning. Results: Compared with FLT3/ITD-negative patients, FLT3/ITD-positive patients had higher median leukocyte count at diagnosis (59 v 21 × 10 9/L; P < .001) and shorter interval from CR to transplantation (87 v 99 days; P = .04). Other characteristics were similar in the two groups. At 2 years, relapse incidence (RI; ± standard deviation) was higher (30% ± 5% v 16% ± 5%; P = .006) and leukemia-free survival (LFS) lower (58%±5% v 71%±6%; P=.04) in FLT3/ITD-positive compared with FLT3/ITD-negative patients. In multivariate analyses, FLT3/ITD led to increased RI (hazard ratio [HR], 3.4; 95% CI, 1.46 to 7.94; P = .005), as did older age, female sex, shorter interval between CR and transplantation, and higher number of chemotherapy courses before achieving CR. FLT3/ITD positivity was associated with decreased LFS (HR, 0.37; 95% CI, 0.19 to 0.73; P=.002), along with older age and higher number of chemotherapy courses before achieving CR. Conclusion: FLT3/ITD adversely affected the outcome of HSCT in the same direction it does after chemotherapy; despite this, more than half of the patients harboring this mutat
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- 2012
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248. Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation
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Schmid, C. (Christoph), Labopin, M. (Myriam), Nagler, A. (Arnon), Niederwieser, D. (Dietger), Castagna, L. (Luca), Tabrizi, R. (Reza), Stadler, M. (Michael), Kuball, J. (Jürgen), Cornelissen, J.J. (Jan), Vorlicek, J. (Jiri), Socié, G. (Gerard), Falda, M. (M.), Vindelov, L. (Lars), Ljungman, P. (Per), Jackson, G. (Graham), Kröger, N. (Nicolaus), Rank, A. (Andreas), Polge, E. (Emmanuelle), Rocha, V. (Vanderson), Mohty, M. (Mohamad), Schmid, C. (Christoph), Labopin, M. (Myriam), Nagler, A. (Arnon), Niederwieser, D. (Dietger), Castagna, L. (Luca), Tabrizi, R. (Reza), Stadler, M. (Michael), Kuball, J. (Jürgen), Cornelissen, J.J. (Jan), Vorlicek, J. (Jiri), Socié, G. (Gerard), Falda, M. (M.), Vindelov, L. (Lars), Ljungman, P. (Per), Jackson, G. (Graham), Kröger, N. (Nicolaus), Rank, A. (Andreas), Polge, E. (Emmanuelle), Rocha, V. (Vanderson), and Mohty, M. (Mohamad)
- Abstract
Because information on management and outcome of AML relapse after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) is scarce, a retrospective registry study was performed by the Acute LeukemiaWorking Party of EBMT. Among 2815 RIC transplants performed for AML in complete remission (CR) between 1999 and 2008, cumulative incidence of relapse was 32% ± 1%. Relapsed patients (263) were included into a detailed analysis of risk factors for overall survival (OS) and building of a prognostic score. CR was reinduced in 32%; remission duration after transplantation was the only prognostic factor for response (P = .003). Estimated 2-year OS from relapse was 14%, thereby resembling results of AML relapse after standard conditioning. Among variables available at the time of relapse, remission after HSCT>5 months (hazard ratio [HR] = 0.50, 95% confidence
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- 2012
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249. Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation
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Madureira, A B M, Eapen, M, Locatelli, Franco, Teira, P, Zhang, M-J, Davies, S M, Picardi, A, Woolfrey, A, Chan, K-W, Socié, G, Vora, A, Bertrand, Y, Sales-Bonfim, C M, Gluckman, E, Niemeyer, C, Rocha, V, Locatelli, F (ORCID:0000-0002-7976-3654), Madureira, A B M, Eapen, M, Locatelli, Franco, Teira, P, Zhang, M-J, Davies, S M, Picardi, A, Woolfrey, A, Chan, K-W, Socié, G, Vora, A, Bertrand, Y, Sales-Bonfim, C M, Gluckman, E, Niemeyer, C, Rocha, V, and Locatelli, F (ORCID:0000-0002-7976-3654)
- Abstract
We describe 70 children with myelodysplastic syndrome (MDS) (refractory cytopenia (n = 31) and refractory anemia with excess blasts (n = 30) or blasts in transformation (n = 9)) who received umbilical cord blood (UCB) transplantation with a single UCB unit and a myeloablative conditioning regimen. Approximately 20% of children had secondary MDS. Median age at transplantation was 7 years and the median follow-up was 3 years. The day-60 probability of neutrophil recovery was 76%; recovery was faster after transplantation of matched or 1-locus mismatched UCB, irradiation-containing conditioning regimen, cell dose > 6 x 10(7)/kg and monosomy 7. Risks of treatment failure (recurrent disease or death) were lower in patients with monosomy 7 and transplantations after 2001. The 3-year disease-free survival (DFS) was 50% for transplantations after 2001 compared with 27% for the earlier period (P = 0.018). Transplantations after 2001 occurred within 6 months after diagnosis and used UCB units with higher cell dose. DFS was highest in patients with monosomy 7 (61%) compared with other karyotypes (30%), P = 0.017. These data suggest that transplantation of mismatched UCB graft is an acceptable alternative for children without a matched sibling or suitably matched unrelated adult donor. Leukemia (2011) 25, 449-454; doi:10.1038/leu.2010.285; published online 7 December 2010
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- 2011
250. Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation.
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Madureira, A. B. M., Eapen, M., Locatelli, F., Teira, P., Zhang, M.-J., Davies, S. M., Picardi, A., Woolfrey, A., Chan, K.-W., Socié, G., Vora, A., Bertrand, Y., Sales-Bonfim, C. M., Gluckman, E., Niemeyer, C., Rocha, V., Socié, G, Eurocord-European Blood and Marrow Transplant Group, Center of International Blood and Marrow Transplant Registry, and European Working Group on childhood MDS
- Subjects
MYELODYSPLASTIC syndromes ,APLASTIC anemia ,CORD blood ,BONE marrow diseases ,DYSPLASIA ,GRAFT versus host disease ,HEMATOPOIETIC stem cell transplantation ,PROGNOSIS ,DISEASE relapse ,TREATMENT effectiveness - Abstract
We describe 70 children with myelodysplastic syndrome (MDS) (refractory cytopenia (n=31) and refractory anemia with excess blasts (n=30) or blasts in transformation (n=9)) who received umbilical cord blood (UCB) transplantation with a single UCB unit and a myeloablative conditioning regimen. Approximately 20% of children had secondary MDS. Median age at transplantation was 7 years and the median follow-up was 3 years. The day-60 probability of neutrophil recovery was 76%; recovery was faster after transplantation of matched or 1-locus mismatched UCB, irradiation-containing conditioning regimen, cell dose >6 × 10(7)/kg and monosomy 7. Risks of treatment failure (recurrent disease or death) were lower in patients with monosomy 7 and transplantations after 2001. The 3-year disease-free survival (DFS) was 50% for transplantations after 2001 compared with 27% for the earlier period (P=0.018). Transplantations after 2001 occurred within 6 months after diagnosis and used UCB units with higher cell dose. DFS was highest in patients with monosomy 7 (61%) compared with other karyotypes (30%), P=0.017. These data suggest that transplantation of mismatched UCB graft is an acceptable alternative for children without a matched sibling or suitably matched unrelated adult donor. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
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