201. The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures
- Author
-
Uter, Wolfgang, Aalto-Korte, Kristiina, Agner, Tove, Andersen, Klaus E., Bircher, Andreas J., Brans, Richard, Bruze, Magnus, Diepgen, Thomas, Foti, Caterina, Giménez Arnau, Anna Maria, Gonçalo, Margarida, Goossens, Alain, McFadden, John, Paulsen, Evy, Svedman, Cecilia, Rustemeyer, Thomas, White, Ian R., Wilkinson, Mark, Johanssen, Jeanne Duus, European Environmental Contact Dermatitis Research Group, Dermatology, and AII - Inflammatory diseases
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Dermatitis ,Dermatology ,Dermatitis, Contact ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,Young Adult ,0302 clinical medicine ,Methylisothiazolinone ,Internal medicine ,medicine ,Humans ,In patient ,ddc:610 ,030212 general & internal medicine ,Child ,Allergic contact dermatitis ,Sensitization ,Al·lèrgia als medicaments ,Adult patients ,business.industry ,Infant ,Methylchloroisothiazolinone ,Middle Aged ,Patch Tests ,medicine.disease ,Europe ,Thiazoles ,Infectious Diseases ,medicine.anatomical_structure ,chemistry ,Contact allergy ,Child, Preschool ,Female ,business ,Follow-Up Studies - Abstract
BACKGROUND: Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action has been taken, at least in Europe, aiming at reducing risk of MI sensitization. OBJECTIVE: To follow-up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)/MI in patients positive to MI which elicited current allergic contact dermatitis. METHODS: A cross-sectional survey was performed in 2016 and 2017, including all adult patients patch tested with the baseline series (including MI 0.2% aq.) between 1 May and 31 October at 14 centres in 11 European countries. Patients with positive reactions (+ to +++) to MI were further examined regarding history, clinical characteristics and eliciting products, which were categorized into 34 types and 4 classes (leave-on, rinse-off, household, occupational). The results were compared with the reference year 2015. RESULTS: A total of 317 patients, n = 202 of 4278 tested in 2016 (4.72%) and n = 115 of 3879 tested in 2017 (2.96%), had positive reactions to MI; the previous result from 2015 was 5.97% (P
- Published
- 2020